Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ce--0253
(610 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 169 4e-41
UniRef50_UPI0000DB6DD3 Cluster: PREDICTED: similar to insulin re... 83 5e-15
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 79 6e-14
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 79 8e-14
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 73 4e-12
UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor... 72 9e-12
UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 70 5e-11
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 67 3e-10
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 65 1e-09
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 64 3e-09
UniRef50_A7RLS2 Cluster: Predicted protein; n=1; Nematostella ve... 61 2e-08
UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC 2.7... 58 1e-07
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 56 7e-07
UniRef50_UPI0000D55DFC Cluster: PREDICTED: similar to Insulin re... 56 9e-07
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 55 1e-06
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 55 2e-06
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 54 2e-06
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 53 5e-06
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 48 1e-04
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 43 0.007
UniRef50_Q9VJ04 Cluster: CG10702-PA, isoform A; n=3; Sophophora|... 42 0.009
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 38 0.19
UniRef50_Q9VFE2 Cluster: CG3837-PA; n=4; Sophophora|Rep: CG3837-... 36 0.57
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 36 0.75
UniRef50_A7AK91 Cluster: Putative uncharacterized protein; n=1; ... 36 0.99
UniRef50_Q1RM89 Cluster: LOC553483 protein; n=5; Danio rerio|Rep... 35 1.3
UniRef50_A6LCK1 Cluster: Putative outer membrane protein/protect... 34 2.3
UniRef50_Q7ULA2 Cluster: Putative uncharacterized protein; n=1; ... 33 4.0
UniRef50_A7L3J5 Cluster: Capsid protein; n=41; Murine norovirus|... 33 5.3
UniRef50_Q176V1 Cluster: Poly(A) polymerase cid; n=3; Culicidae|... 33 5.3
UniRef50_Q8A0Q6 Cluster: Putative uncharacterized protein; n=2; ... 32 9.3
UniRef50_Q9M2N3 Cluster: Putative uncharacterized protein T27B3.... 32 9.3
UniRef50_A6NKG6 Cluster: Uncharacterized protein ENSP00000343970... 32 9.3
>UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor;
n=1; Bombyx mori|Rep: Insulin receptor-like protein
precursor - Bombyx mori (Silk moth)
Length = 1472
Score = 169 bits (411), Expect = 4e-41
Identities = 83/97 (85%), Positives = 86/97 (88%)
Frame = +2
Query: 2 CQPVPAVPACVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEI 181
CQP P CVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEI
Sbjct: 355 CQPCPR-SGCVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEI 413
Query: 182 REIHGCLQVTRSYPLVSLMFLKKLRKLSRILQKIKGK 292
REIHGCLQVTRSYPLVSLMFLKKLRK+ + KG+
Sbjct: 414 REIHGCLQVTRSYPLVSLMFLKKLRKIIANPSEDKGE 450
Score = 166 bits (403), Expect = 4e-40
Identities = 74/88 (84%), Positives = 77/88 (87%)
Frame = +1
Query: 244 EETQKIIANPSEDKGEALHXXXXXXXXXXWDWSTYGPIEIIGSCYIHSNPKLCYTQLMPL 423
++ +KIIANPSEDKGEALH WDWSTYGPIEIIGSCYIHSNPKLCYTQLMPL
Sbjct: 435 KKLRKIIANPSEDKGEALHIINNENLELLWDWSTYGPIEIIGSCYIHSNPKLCYTQLMPL 494
Query: 424 MNMSYPKTNFTELEVSQDSNGYQASCLP 507
MNMSYPKTNFTELEVSQDSNGYQASCLP
Sbjct: 495 MNMSYPKTNFTELEVSQDSNGYQASCLP 522
Score = 53.6 bits (123), Expect = 4e-06
Identities = 24/25 (96%), Positives = 24/25 (96%)
Frame = +3
Query: 504 PGVLKLSVSELTQIAVVLTWDVYCP 578
P VLKLSVSELTQIAVVLTWDVYCP
Sbjct: 522 PDVLKLSVSELTQIAVVLTWDVYCP 546
>UniRef50_UPI0000DB6DD3 Cluster: PREDICTED: similar to insulin
receptor; n=1; Apis mellifera|Rep: PREDICTED: similar to
insulin receptor - Apis mellifera
Length = 835
Score = 83.0 bits (196), Expect = 5e-15
Identities = 39/78 (50%), Positives = 53/78 (67%), Gaps = 1/78 (1%)
Frame = +2
Query: 26 ACVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTL-SLLESALGEIREIHGCL 202
+C +EC G +DS+A+A++ RGCTHI G +E +R GGK + LE L I EI G L
Sbjct: 490 SCQKECAGANVDSIASAQKLRGCTHITGSLEIQIR--GGKNIVKELEDGLSTIEEIDGYL 547
Query: 203 QVTRSYPLVSLMFLKKLR 256
++ RS+PL+SL FLK LR
Sbjct: 548 KIVRSFPLISLNFLKNLR 565
Score = 39.1 bits (87), Expect = 0.081
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Frame = +1
Query: 331 WDWSTYGPIEII-----GSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQA 495
WDWS + I I G + H NPKLC ++ L + FT+ EV+ +SNG +
Sbjct: 591 WDWSLHKEISIKSKDGPGKIFFHLNPKLCLYKIEMLREKA-GLGPFTDYEVAPNSNGDKV 649
Query: 496 SC 501
+C
Sbjct: 650 AC 651
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 79.4 bits (187), Expect = 6e-14
Identities = 37/82 (45%), Positives = 52/82 (63%)
Frame = +2
Query: 11 VPAVPACVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREI 190
+P C+++C G +DS+ A Q +GCTHI +E +R G ++ LE +LG I EI
Sbjct: 337 IPCQGNCIKKCAGVNVDSINLARQLKGCTHITSSLEIQIR-GGRNVVNELEESLGMIEEI 395
Query: 191 HGCLQVTRSYPLVSLMFLKKLR 256
G L+V RS+PLVSL FLK L+
Sbjct: 396 DGYLKVVRSFPLVSLNFLKNLK 417
Score = 46.4 bits (105), Expect = 5e-04
Identities = 21/58 (36%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Frame = +1
Query: 331 WDWSTYGPIEI-IGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
W+W ++I G + H NPKLC ++ L N+++ + TELEV+++SNG + +C
Sbjct: 443 WNWENNKTLKIDTGRLFFHFNPKLCIREIEKLQNITH-IVDVTELEVAKNSNGDKIAC 499
>UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin
receptor; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to insulin receptor - Nasonia vitripennis
Length = 1714
Score = 79.0 bits (186), Expect = 8e-14
Identities = 37/75 (49%), Positives = 51/75 (68%)
Frame = +2
Query: 29 CVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQV 208
C+REC G +DS+ATA++ RGC+HIKG +E +R G + LE +L I I G L++
Sbjct: 394 CLRECTGIVVDSIATAQKLRGCSHIKGNLEIAVR-EGQNIVHELEESLSNIEVITGYLKI 452
Query: 209 TRSYPLVSLMFLKKL 253
RS+PL+SL FLK L
Sbjct: 453 FRSFPLISLSFLKNL 467
Score = 37.5 bits (83), Expect = 0.25
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Frame = +1
Query: 331 WDWSTYGPIEI-----IGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQA 495
W+W+T P++I + H NPKLC + L + F E+EVS SNG +
Sbjct: 494 WNWTTRPPLKIGSSNPVPKVSFHYNPKLCLQTIEELRERT-GLNPFREVEVSPTSNGDKV 552
Query: 496 SC 501
+C
Sbjct: 553 AC 554
>UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain]; n=2; Aedes
aegypti|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain] - Aedes aegypti
(Yellowfever mosquito)
Length = 1390
Score = 73.3 bits (172), Expect = 4e-12
Identities = 37/77 (48%), Positives = 49/77 (63%), Gaps = 1/77 (1%)
Frame = +2
Query: 29 CVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTL-SLLESALGEIREIHGCLQ 205
C + C G ID++ +A+ +GC I G +E LRS GG+ + LE+ L I EI G L+
Sbjct: 352 CPKRCEGSNIDNIQSAQLLKGCEIIDGSLEIQLRSRGGENIVKELENFLSSITEIKGYLK 411
Query: 206 VTRSYPLVSLMFLKKLR 256
V RSYPL SL FLKKL+
Sbjct: 412 VVRSYPLPSLGFLKKLK 428
>UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor
(EC 2.7.10.1) (ILP receptor) [Contains: Insulin-like
peptide receptor alpha chain; Insulin-like peptide
receptor beta chain]; n=4; Eukaryota|Rep: Insulin-like
peptide receptor precursor (EC 2.7.10.1) (ILP receptor)
[Contains: Insulin-like peptide receptor alpha chain;
Insulin-like peptide receptor beta chain] -
Branchiostoma lanceolatum (Common lancelet) (Amphioxus)
Length = 1363
Score = 72.1 bits (169), Expect = 9e-12
Identities = 36/87 (41%), Positives = 57/87 (65%)
Frame = +2
Query: 29 CVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQV 208
C + C GG +DS+A A++FRGCT I+G+++ ++R G + LE LG I E+ + +
Sbjct: 316 CPKSCKGGLVDSLAAAQRFRGCTIIEGELKISIR-GGDNIIDELEENLGLIEEVGHYVAI 374
Query: 209 TRSYPLVSLMFLKKLRKLSRILQKIKG 289
RSY LV+L FL+ L+++ R +QK G
Sbjct: 375 VRSYALVTLDFLRSLKRI-RGIQKENG 400
Score = 37.5 bits (83), Expect = 0.25
Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 1/83 (1%)
Frame = +1
Query: 256 KIIANPSEDKGEALHXXXXXXXXXXWDWSTYGPIEIIGSCYIHSNPKLCYTQLMPLMN-M 432
K I ++ G A + +DW G + H NPKLC ++ +++ +
Sbjct: 390 KRIRGIQKENGYAFYVLDNRNLEKLFDWDRTDITIDEGKLFFHFNPKLCRHVILTMVDKV 449
Query: 433 SYPKTNFTELEVSQDSNGYQASC 501
P+ T+ ++S +NG QA C
Sbjct: 450 GLPEHAITDTDISTLTNGDQAQC 472
>UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1419
Score = 69.7 bits (163), Expect = 5e-11
Identities = 36/82 (43%), Positives = 49/82 (59%), Gaps = 1/82 (1%)
Frame = +2
Query: 14 PAVPACVRECLGGK-IDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREI 190
P C + C+G K +DSV A+ RGCT + G + LR G + +E++LG++ EI
Sbjct: 323 PCAGLCPKVCMGLKMVDSVTAAQDLRGCTVLNGSLVINLRG-GNNIAAEMEASLGQLEEI 381
Query: 191 HGCLQVTRSYPLVSLMFLKKLR 256
G L V RSY LVSL F +KLR
Sbjct: 382 TGYLTVRRSYALVSLSFFRKLR 403
Score = 40.7 bits (91), Expect = 0.026
Identities = 17/57 (29%), Positives = 31/57 (54%)
Frame = +1
Query: 331 WDWSTYGPIEIIGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
WDWS + + G + H N KLC +++ + ++ K + +++ +NG QASC
Sbjct: 429 WDWSKHKLSILQGRMFFHYNSKLCMSEIHKMEEVTGTKQRQVKNDIALKTNGDQASC 485
>UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2;
Cellia|Rep: Tyrosine-protein kinase receptor - Anopheles
gambiae str. PEST
Length = 1318
Score = 67.3 bits (157), Expect = 3e-10
Identities = 35/83 (42%), Positives = 48/83 (57%), Gaps = 1/83 (1%)
Frame = +2
Query: 11 VPAVPACVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGK-TLSLLESALGEIRE 187
VP C EC G I+S++ +Q RGCT I+G + LR GG+ + LE L I E
Sbjct: 337 VPCKGPCRSECKGMVIESISQMQQLRGCTIIQGSLSIRLRQLGGENVVRELEKVLYSIEE 396
Query: 188 IHGCLQVTRSYPLVSLMFLKKLR 256
I+G L + RSY L+SL F + L+
Sbjct: 397 IYGYLTIVRSYALMSLGFFRNLK 419
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 64.9 bits (151), Expect = 1e-09
Identities = 40/86 (46%), Positives = 53/86 (61%), Gaps = 5/86 (5%)
Frame = +2
Query: 14 PAVPACVREC--LGGK--IDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSL-LESALGE 178
P + C + C L G+ IDSV +A++ RGCT I G + +R GG L+ LE+ LG
Sbjct: 330 PCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIR--GGNNLAAELEANLGL 387
Query: 179 IREIHGCLQVTRSYPLVSLMFLKKLR 256
I EI G L++ RSY LVSL F +KLR
Sbjct: 388 IEEISGYLKIRRSYALVSLSFFRKLR 413
Score = 43.6 bits (98), Expect = 0.004
Identities = 18/57 (31%), Positives = 30/57 (52%)
Frame = +1
Query: 331 WDWSTYGPIEIIGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
WDWS + G + H NPKLC +++ + +S K +++ +NG +ASC
Sbjct: 439 WDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDKASC 495
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 63.7 bits (148), Expect = 3e-09
Identities = 34/67 (50%), Positives = 43/67 (64%)
Frame = +2
Query: 56 IDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQVTRSYPLVSL 235
IDSV +A++ RGCT I G + LR G + LE+ LG I EI G L++ RSY LVSL
Sbjct: 358 IDSVTSAQELRGCTVINGSLIINLRG-GNNIATELEANLGLIEEISGYLKIRRSYALVSL 416
Query: 236 MFLKKLR 256
F +KLR
Sbjct: 417 SFFRKLR 423
Score = 44.4 bits (100), Expect = 0.002
Identities = 18/57 (31%), Positives = 31/57 (54%)
Frame = +1
Query: 331 WDWSTYGPIEIIGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
WDW + I G + H NP+LC +Q+ + ++ K + +++ +NG QASC
Sbjct: 449 WDWHKHNLTIIHGKLFFHHNPRLCLSQIHQMEEVTGTKGRQDKNDIATKTNGDQASC 505
>UniRef50_A7RLS2 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1004
Score = 60.9 bits (141), Expect = 2e-08
Identities = 29/70 (41%), Positives = 40/70 (57%)
Frame = +2
Query: 47 GGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQVTRSYPL 226
GG IDS+++ ++GCT IKG +E LR G LE LG I + G + + S +
Sbjct: 284 GGIIDSISSLRHYKGCTDIKGNLEIKLRGGGQTIAKELEDNLGMIERVTGYIVIRESVAI 343
Query: 227 VSLMFLKKLR 256
V+L FLK LR
Sbjct: 344 VTLKFLKNLR 353
Score = 32.7 bits (71), Expect = 7.0
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 4/59 (6%)
Frame = +1
Query: 337 WSTYGPIEII-GSCYIHSNPKLCYTQLMPLMNMSYPKTNFT---ELEVSQDSNGYQASC 501
W ++I G + NP+LC ++ PL+N TN + ++VSQ SNG +C
Sbjct: 391 WDFRSDLQITAGGILVRMNPRLCPGRIDPLVNDVLQWTNASLGRPVDVSQTSNGNAVAC 449
>UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2]; n=15;
Eumetazoa|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2] -
Drosophila melanogaster (Fruit fly)
Length = 2144
Score = 58.4 bits (135), Expect = 1e-07
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 3/91 (3%)
Frame = +2
Query: 2 CQPVPAVPACVRECLGGKIDSVATAEQFRGCTHIKGKMEFTL---RSSGGKTLSLLESAL 172
C+P P C +EC G IDS+ A +F GCT I G T+ R SG + L+ L
Sbjct: 635 CEPCPG-GKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGL 693
Query: 173 GEIREIHGCLQVTRSYPLVSLMFLKKLRKLS 265
+ +I L V +Y L SL F + L ++S
Sbjct: 694 AAVHKIQSSLMVHLTYGLKSLKFFQSLTEIS 724
Score = 38.7 bits (86), Expect = 0.11
Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 1/46 (2%)
Frame = +1
Query: 367 GSCYIHSNPKLCYTQLMPLMNMSYPKTNFTE-LEVSQDSNGYQASC 501
G + H NPKLC + + L+ M K F E +V DSNG + SC
Sbjct: 759 GGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSC 804
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain;
Putative molluscan insulin-related peptide(s) receptor
beta chain] - Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 56.0 bits (129), Expect = 7e-07
Identities = 27/76 (35%), Positives = 44/76 (57%)
Frame = +2
Query: 29 CVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQV 208
C +EC G +I+++ A + + C+ I G ++ + S G LE +LG IRE+ + +
Sbjct: 354 CPKECHGLEINNIQDAHKLKECSKISGPLKIQIMS-GSNVAQELEKSLGNIREVTETIHI 412
Query: 209 TRSYPLVSLMFLKKLR 256
RSY LV+L F K L+
Sbjct: 413 KRSYALVTLHFFKNLQ 428
>UniRef50_UPI0000D55DFC Cluster: PREDICTED: similar to Insulin
receptor-related protein precursor (IRR) (IR-related
receptor); n=1; Tribolium castaneum|Rep: PREDICTED:
similar to Insulin receptor-related protein precursor
(IRR) (IR-related receptor) - Tribolium castaneum
Length = 655
Score = 55.6 bits (128), Expect = 9e-07
Identities = 33/74 (44%), Positives = 42/74 (56%)
Frame = +2
Query: 41 CLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQVTRSY 220
C G KI + EQ CTHI G +E +L G +LS LE LG+I I L++TRS+
Sbjct: 20 CEGMKIVNHFELEQMVNCTHINGSLELSL--VGSVSLSDLERTLGKIVSISKYLKITRSH 77
Query: 221 PLVSLMFLKKLRKL 262
L SL F KLR +
Sbjct: 78 KLTSLQFFDKLRTI 91
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 55.2 bits (127), Expect = 1e-06
Identities = 31/81 (38%), Positives = 43/81 (53%)
Frame = +2
Query: 14 PAVPACVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIH 193
P C E IDSV +A+ +GCT KG + +R G S LE+ +G I +
Sbjct: 327 PCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRR-GNNIASELENFMGLIEVVT 385
Query: 194 GCLQVTRSYPLVSLMFLKKLR 256
G +++ S+ LVSL FLK LR
Sbjct: 386 GYVKIRHSHALVSLSFLKNLR 406
Score = 36.7 bits (81), Expect = 0.43
Identities = 16/57 (28%), Positives = 29/57 (50%)
Frame = +1
Query: 331 WDWSTYGPIEIIGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
WDW G Y NPKLC +++ + ++ K ++ +++ +NG +ASC
Sbjct: 432 WDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASC 488
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 54.8 bits (126), Expect = 2e-06
Identities = 28/67 (41%), Positives = 41/67 (61%)
Frame = +2
Query: 56 IDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQVTRSYPLVSL 235
IDSV +A+ GCT +KG ++ +R G + LE+ LG I + G +++ S+ LVSL
Sbjct: 335 IDSVTSAQMLEGCTVLKGNLQLNIRK-GQNIAAELENFLGLIETVTGYVKIRHSHALVSL 393
Query: 236 MFLKKLR 256
FLK LR
Sbjct: 394 SFLKSLR 400
Score = 35.1 bits (77), Expect = 1.3
Identities = 17/57 (29%), Positives = 27/57 (47%)
Frame = +1
Query: 331 WDWSTYGPIEIIGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
WDWS + G N KLC +++ + ++ K E ++S +NG ASC
Sbjct: 426 WDWSKHNLTIKEGKIRFAFNSKLCASEIYRMEEVTGTKGRQAEEDISLSTNGNMASC 482
>UniRef50_P14616 Cluster: Insulin receptor-related protein precursor
(EC 2.7.10.1) (IRR) (IR- related receptor) [Contains:
Insulin receptor-related protein alpha chain; Insulin
receptor-related protein beta chain]; n=14;
Eutheria|Rep: Insulin receptor-related protein precursor
(EC 2.7.10.1) (IRR) (IR- related receptor) [Contains:
Insulin receptor-related protein alpha chain; Insulin
receptor-related protein beta chain] - Homo sapiens
(Human)
Length = 1297
Score = 54.4 bits (125), Expect = 2e-06
Identities = 31/78 (39%), Positives = 45/78 (57%), Gaps = 2/78 (2%)
Frame = +2
Query: 29 CVREC-LGGK-IDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCL 202
C +EC +G K IDS+ A+ GCTH++G + LR G L+ +LG + I G L
Sbjct: 324 CPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLR-QGYNLEPQLQHSLGLVETITGFL 382
Query: 203 QVTRSYPLVSLMFLKKLR 256
++ S+ LVSL F K L+
Sbjct: 383 KIKHSFALVSLGFFKNLK 400
>UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2;
Strongylocentrotus purpuratus|Rep: Tyrosine-protein
kinase receptor - Strongylocentrotus purpuratus (Purple
sea urchin)
Length = 1072
Score = 53.2 bits (122), Expect = 5e-06
Identities = 31/74 (41%), Positives = 39/74 (52%)
Frame = +2
Query: 41 CLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQVTRSY 220
C G I SV A RGCT++ G + ++ G L LE LG I I L V R+
Sbjct: 31 CKGKTIQSVEDAADMRGCTYVHGTLTISVHGRGN-VLKELERNLGMIEVISDALIVRRAN 89
Query: 221 PLVSLMFLKKLRKL 262
LVSL FL+ LRK+
Sbjct: 90 SLVSLNFLRNLRKI 103
Score = 46.8 bits (106), Expect = 4e-04
Identities = 22/58 (37%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Frame = +1
Query: 331 WDWSTYGPIEII-GSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
+D+S + I I+ G + H NPKLCY+++ L N++ K + ++VS SNG Q +C
Sbjct: 129 FDFSQHPNITIVNGKFFFHYNPKLCYSEIEELHNLTGIKEPLSNVDVSLSSNGDQVAC 186
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen);
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 48.4 bits (110), Expect = 1e-04
Identities = 27/73 (36%), Positives = 39/73 (53%)
Frame = +2
Query: 35 RECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHGCLQVTR 214
+EC GG I+ + ++ + CTHI +E LR + + LE LG + I G L V+R
Sbjct: 302 KECRGGLIEKLDVLQEMKDCTHINTSLE--LRITQDYLVPYLEKYLGNVVSISGYLNVSR 359
Query: 215 SYPLVSLMFLKKL 253
S + SL F K L
Sbjct: 360 SGNIKSLEFFKNL 372
>UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia
malayi|Rep: Bm-DAF-2 precursor - Brugia malayi (Filarial
nematode worm)
Length = 1456
Score = 42.7 bits (96), Expect = 0.007
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Frame = +2
Query: 29 CVRECLGGKIDSVATAEQ--FRGCTHIKGKMEFTLRSS-GGKTLSLLESALGEIREIHGC 199
C +C GG IDS A F+ C I+G +E LR + + ALG I I G
Sbjct: 336 CPVKCKGGTIDSFARINDYLFKKCNVIEGYLEIELRKGLDAAGMEKIGEALGYIEVIEGY 395
Query: 200 LQVTRSYPLVSLMFLKKLR 256
L + S +SL K+LR
Sbjct: 396 LLIDFSISFISLHMFKRLR 414
>UniRef50_Q9VJ04 Cluster: CG10702-PA, isoform A; n=3;
Sophophora|Rep: CG10702-PA, isoform A - Drosophila
melanogaster (Fruit fly)
Length = 946
Score = 42.3 bits (95), Expect = 0.009
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Frame = +2
Query: 2 CQPVPA-VPACVRECLGGK--IDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESAL 172
C P A + C E G + ++A AE RGC G + T+R+ +T L +
Sbjct: 296 CSPDEACISFCTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNETQ--LYQSF 353
Query: 173 GEIREIHGCLQVTRSYPLVSLMFLKKLRKL 262
+RE+ G ++V RS L SL FL+ L ++
Sbjct: 354 TSMREVRGHVKVYRSSQLRSLQFLRNLERV 383
>UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2;
Schistosoma|Rep: Insulin receptor protein kinase -
Schistosoma mansoni (Blood fluke)
Length = 1499
Score = 37.9 bits (84), Expect = 0.19
Identities = 25/85 (29%), Positives = 37/85 (43%)
Frame = +2
Query: 2 CQPVPAVPACVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSLLESALGEI 181
CQ P R C + V+ +Q RGC + + G T ++ A ++
Sbjct: 332 CQFCPDSNCIKRACGDINVYKVSDLKQVRGCVTAQSILISIRDCEDGDTSKFMD-AFSDL 390
Query: 182 REIHGCLQVTRSYPLVSLMFLKKLR 256
+EIH L + S L SL FL+ LR
Sbjct: 391 KEIHTSLHIISSDSLQSLTFLRSLR 415
>UniRef50_Q9VFE2 Cluster: CG3837-PA; n=4; Sophophora|Rep: CG3837-PA
- Drosophila melanogaster (Fruit fly)
Length = 868
Score = 36.3 bits (80), Expect = 0.57
Identities = 15/45 (33%), Positives = 24/45 (53%)
Frame = +1
Query: 367 GSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASC 501
G+ + H NP+LCY ++ L N + +VS +SNG + C
Sbjct: 439 GTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVIC 483
>UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n=2;
Caenorhabditis briggsae|Rep: Dauer abnormal formation-2
precursor - Caenorhabditis briggsae
Length = 1807
Score = 35.9 bits (79), Expect = 0.75
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 1/69 (1%)
Frame = +2
Query: 53 KIDSVATAEQFRGCTHIKGKMEFTLRSSGGKTLSL-LESALGEIREIHGCLQVTRSYPLV 229
KID+ A R C IKG + +R ++ L+ I I L + RS PL+
Sbjct: 483 KIDTFPKALALRRCNIIKGNLTIEIRGKQESGMAAELKEVFANIHTITEYLHIMRSPPLL 542
Query: 230 SLMFLKKLR 256
SL K+L+
Sbjct: 543 SLAMFKRLK 551
>UniRef50_A7AK91 Cluster: Putative uncharacterized protein; n=1;
Parabacteroides merdae ATCC 43184|Rep: Putative
uncharacterized protein - Parabacteroides merdae ATCC
43184
Length = 774
Score = 35.5 bits (78), Expect = 0.99
Identities = 21/78 (26%), Positives = 36/78 (46%), Gaps = 10/78 (12%)
Frame = -2
Query: 306 YYMQSFPFIF*RIRDNFLSFFKNINDTKGY---------DRVTCRHPWISLISPSADSN- 157
Y+ PF+F + F KNI KG+ D HPW +L+ +++
Sbjct: 323 YHAALHPFVFQDVDGRFRGLDKNIEQAKGFTNYTTFSLWDTYRALHPWFNLVHQDINADI 382
Query: 156 NDSVLPPLERSVNSILPL 103
+S+L ++SV +LP+
Sbjct: 383 ANSMLAHFDKSVEKMLPI 400
>UniRef50_Q1RM89 Cluster: LOC553483 protein; n=5; Danio rerio|Rep:
LOC553483 protein - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 375
Score = 35.1 bits (77), Expect = 1.3
Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 4/91 (4%)
Frame = +3
Query: 285 RGSSAYNKQRESRAAMGLVHLRTYRDNR*LLHTFES----QAVLHSTDAAYEYVVSENEF 452
R SA+NK + + R+ +D+R + H ES A+L ST + + + E EF
Sbjct: 191 RTHSAHNKINGNHSKFSDFVSRSDQDSRLVSHGEESLTEAMALLKSTQSTLDELHKECEF 250
Query: 453 YRTRSVPRQQRVSGILSPGVLKLSVSELTQI 545
++ S S +LSP LKL++S+++Q+
Sbjct: 251 LQSHSSG-----SAVLSPCALKLAISDMSQL 276
>UniRef50_A6LCK1 Cluster: Putative outer membrane protein/protective
antigen OMA87; n=1; Parabacteroides distasonis ATCC
8503|Rep: Putative outer membrane protein/protective
antigen OMA87 - Parabacteroides distasonis (strain ATCC
8503 / DSM 20701 / NCTC11152)
Length = 819
Score = 34.3 bits (75), Expect = 2.3
Identities = 26/68 (38%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Frame = +2
Query: 20 VPACVRECLGGKIDSVATAEQFRG-CTHIKGKMEFTLRSSGGKTLSLLESALGEIREIHG 196
VP+ E LGG +D V AE F G K K + L+ GG T S LES REI+
Sbjct: 62 VPSATIETLGGGMDIVGQAEGFHGLLLENKRKQLYLLKPLGGST-SFLESKF--FREIYN 118
Query: 197 CLQVTRSY 220
+Y
Sbjct: 119 KTDFKNTY 126
>UniRef50_Q7ULA2 Cluster: Putative uncharacterized protein; n=1;
Pirellula sp.|Rep: Putative uncharacterized protein -
Rhodopirellula baltica
Length = 443
Score = 33.5 bits (73), Expect = 4.0
Identities = 13/35 (37%), Positives = 20/35 (57%)
Frame = +1
Query: 424 MNMSYPKTNFTELEVSQDSNGYQASCLPXXXXXXC 528
M+++YP T+F EL + QDSN + +C C
Sbjct: 1 MSLTYPLTHFEELMLHQDSNAFPTNCFVRMRFRGC 35
>UniRef50_A7L3J5 Cluster: Capsid protein; n=41; Murine
norovirus|Rep: Capsid protein - Murine norovirus 6
Length = 541
Score = 33.1 bits (72), Expect = 5.3
Identities = 14/36 (38%), Positives = 23/36 (63%)
Frame = -2
Query: 183 LISPSADSNNDSVLPPLERSVNSILPLMCVQPRNCS 76
L P+AD N + PP+ER++ ++ L +QPR C+
Sbjct: 206 LSKPAADFNFVYLTPPIERTIYRMVDLPVIQPRLCT 241
>UniRef50_Q176V1 Cluster: Poly(A) polymerase cid; n=3;
Culicidae|Rep: Poly(A) polymerase cid - Aedes aegypti
(Yellowfever mosquito)
Length = 1143
Score = 33.1 bits (72), Expect = 5.3
Identities = 20/66 (30%), Positives = 37/66 (56%)
Frame = -2
Query: 243 KNINDTKGYDRVTCRHPWISLISPSADSNNDSVLPPLERSVNSILPLMCVQPRNCSAVAT 64
K +N + G+ RHP ++ISPS S++ SV+P S ++++ + P + S++
Sbjct: 109 KLLNGSGGFS-ANHRHP-AAVISPSHSSSSGSVIPSSSSSSSTVVASL---PSSASSITR 163
Query: 63 ESIFPP 46
S+ PP
Sbjct: 164 SSLTPP 169
>UniRef50_Q8A0Q6 Cluster: Putative uncharacterized protein; n=2;
Bacteroides|Rep: Putative uncharacterized protein -
Bacteroides thetaiotaomicron
Length = 756
Score = 32.3 bits (70), Expect = 9.3
Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 10/78 (12%)
Frame = -2
Query: 306 YYMQSFPFIF*RIRDNFLSFFKNINDTKGY---------DRVTCRHPWISLISPSADSN- 157
Y+ PFIF F KNI +G+ D HPW +L+ +++
Sbjct: 305 YHAALHPFIFQDSDGQFRGLDKNIEKAEGFTNYTVFSLWDTYRALHPWFNLVQQEVNADI 364
Query: 156 NDSVLPPLERSVNSILPL 103
+S+L ++SV +LP+
Sbjct: 365 ANSMLAHYDKSVEKMLPI 382
>UniRef50_Q9M2N3 Cluster: Putative uncharacterized protein T27B3.60;
n=1; Arabidopsis thaliana|Rep: Putative uncharacterized
protein T27B3.60 - Arabidopsis thaliana (Mouse-ear
cress)
Length = 695
Score = 32.3 bits (70), Expect = 9.3
Identities = 20/74 (27%), Positives = 32/74 (43%), Gaps = 2/74 (2%)
Frame = -2
Query: 258 FLSFFKNINDTKGYDRVTCRHPWISLISPSAD--SNNDSVLPPLERSVNSILPLMCVQPR 85
F S + N Y V H SL++ + S N+S+L P E ++N + C QP
Sbjct: 414 FQSAAEKGNSESNYASVKVTHTPASLVNEVGEIVSVNESILSPKESTINEESQIQCAQPT 473
Query: 84 NCSAVATESIFPPR 43
+ V ++ R
Sbjct: 474 SGDGVHLSNVVEER 487
>UniRef50_A6NKG6 Cluster: Uncharacterized protein ENSP00000343970;
n=1; Homo sapiens|Rep: Uncharacterized protein
ENSP00000343970 - Homo sapiens (Human)
Length = 118
Score = 32.3 bits (70), Expect = 9.3
Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 1/70 (1%)
Frame = -2
Query: 210 VTCRH-PWISLISPSADSNNDSVLPPLERSVNSILPLMCVQPRNCSAVATESIFPPRHSR 34
+ CRH PW++ +SP + + P + S + L P + S V PP S
Sbjct: 39 IGCRHTPWVTALSPRPKGQPEPLSPEVPLSSGLLSTLAWGSPNSSSRVPEAQ--PPAPSL 96
Query: 33 TQAGTAGTGW 4
+ G T W
Sbjct: 97 AETGPPRTCW 106
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 573,596,723
Number of Sequences: 1657284
Number of extensions: 10590188
Number of successful extensions: 30113
Number of sequences better than 10.0: 33
Number of HSP's better than 10.0 without gapping: 29062
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 30090
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 43562448615
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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