Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brS-0634
(544 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 244 1e-63
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 219 3e-56
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 190 1e-47
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 179 3e-44
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 165 8e-40
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 152 4e-36
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 151 1e-35
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 151 1e-35
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 150 2e-35
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 149 3e-35
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 138 6e-32
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 135 5e-31
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 129 4e-29
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 126 4e-28
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 125 8e-28
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 125 8e-28
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 123 2e-27
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 118 7e-26
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 118 9e-26
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 114 1e-24
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 111 1e-23
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 109 4e-23
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 107 2e-22
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 103 2e-21
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 103 2e-21
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 99 3e-20
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 95 9e-19
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 91 2e-17
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 91 2e-17
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 90 4e-17
UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 88 1e-16
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 87 2e-16
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 85 8e-16
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 85 1e-15
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 85 1e-15
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 85 1e-15
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 84 2e-15
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 82 9e-15
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 82 9e-15
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 81 2e-14
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 81 2e-14
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 81 2e-14
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 80 4e-14
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 80 4e-14
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 77 2e-13
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 77 3e-13
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 77 3e-13
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 76 6e-13
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 75 1e-12
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 71 2e-11
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 68 2e-10
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 67 2e-10
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 66 5e-10
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 65 9e-10
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 65 1e-09
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 64 2e-09
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 63 3e-09
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 63 3e-09
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 63 3e-09
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 62 6e-09
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 62 8e-09
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 61 1e-08
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 56 4e-07
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 56 4e-07
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 55 1e-06
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 55 1e-06
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 55 1e-06
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 54 2e-06
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 54 2e-06
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 54 3e-06
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 52 7e-06
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 52 1e-05
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 52 1e-05
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 52 1e-05
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 52 1e-05
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 51 2e-05
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 51 2e-05
UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2; L... 50 3e-05
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 50 3e-05
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 50 5e-05
UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_030007... 48 1e-04
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 48 1e-04
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 48 1e-04
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 48 1e-04
UniRef50_Q08522 Cluster: Putative uncharacterized protein YOR135... 47 3e-04
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 46 6e-04
UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 46 6e-04
UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3; B... 46 6e-04
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 46 7e-04
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 46 7e-04
UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2; H... 45 0.001
UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenas... 45 0.001
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 44 0.002
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 44 0.003
UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1; A... 43 0.004
UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;... 43 0.004
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 43 0.005
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 43 0.005
UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1; ... 42 0.007
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 42 0.012
UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42; ... 42 0.012
UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3; A... 41 0.021
UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3; D... 40 0.028
UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2; N... 40 0.037
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 39 0.065
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 39 0.065
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 39 0.086
UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1; ... 38 0.11
UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11; ... 38 0.11
UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7; G... 38 0.15
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 38 0.20
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 37 0.26
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 37 0.35
UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1; C... 36 0.46
UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1; ... 36 0.46
UniRef50_Q6JAD6 Cluster: Putative uncharacterized protein; n=1; ... 35 1.1
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 35 1.4
UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30; ... 35 1.4
UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep: P... 34 1.8
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 34 1.8
UniRef50_Q7RB56 Cluster: Fulmal1; n=2; Plasmodium (Vinckeia)|Rep... 34 2.4
UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2; Brady... 33 3.2
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 33 3.2
UniRef50_UPI0000D5678D Cluster: PREDICTED: similar to CG33087-PC... 33 5.6
UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1; P... 33 5.6
UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10... 32 7.4
UniRef50_Q1ASC3 Cluster: Phosphomethylpyrimidine kinase type-2; ... 32 7.4
UniRef50_A5DW24 Cluster: Putative uncharacterized protein; n=2; ... 32 7.4
UniRef50_Q4RK60 Cluster: Chromosome 2 SCAF15032, whole genome sh... 32 9.8
UniRef50_Q2S2N6 Cluster: Possible 2-hydroxyhepta-2,4-diene-1,7-d... 32 9.8
UniRef50_A7CVJ0 Cluster: Putative uncharacterized protein precur... 32 9.8
UniRef50_A6DQ62 Cluster: Phosphomannomutase; n=1; Lentisphaera a... 32 9.8
UniRef50_P83723 Cluster: Unknown protein NF004 from 2D-PAGE; n=7... 32 9.8
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 244 bits (597), Expect = 1e-63
Identities = 120/169 (71%), Positives = 140/169 (82%), Gaps = 1/169 (0%)
Frame = +1
Query: 40 MAARIIRKIVPATRAGAAQYSTG-VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEV 216
M + I+K +T + +YS+G VR+VTLIPG GIGPEI+ +VQKIFEAA PI W+ V
Sbjct: 1 MLGKCIKK-ASSTVGQSIRYSSGDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPV 59
Query: 217 DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRP 396
DVT V+G DG F IP + I+ ++ANK+GLKGPL TP+GKG+RSLNLA+RKEF LYANVRP
Sbjct: 60 DVTPVKGRDGVFRIPSRCIELMHANKVGLKGPLETPIGKGHRSLNLAVRKEFSLYANVRP 119
Query: 397 CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEA 543
C+SLEG KTLYDNVDVVTIRENTEGEYSGIEHEIV GVVQSIKLITE A
Sbjct: 120 CRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETA 168
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 219 bits (535), Expect = 3e-56
Identities = 103/149 (69%), Positives = 125/149 (83%)
Frame = +1
Query: 97 YSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAID 276
++ GV+ VTLIPG GIGPEI+ AV KIF+AAK PI+WEE +VTA++GP GK+ IP +A +
Sbjct: 27 FTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKE 86
Query: 277 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 456
S++ NK+GLKGPL TP+ G+ S+NL LRK FDLYANVRPC S+EG KT Y +V++VTIR
Sbjct: 87 SMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIR 146
Query: 457 ENTEGEYSGIEHEIVDGVVQSIKLITEEA 543
ENTEGEYSGIEH IVDGVVQSIKLITE A
Sbjct: 147 ENTEGEYSGIEHVIVDGVVQSIKLITEGA 175
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 190 bits (464), Expect = 1e-47
Identities = 94/153 (61%), Positives = 112/153 (73%)
Frame = +1
Query: 85 GAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQ 264
G STG V+ I G GIGPEI+ +V+KIF AA VPIEWE DV+ + +G IP
Sbjct: 28 GKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIF-VNGLTTIPD 86
Query: 265 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDV 444
A+ S+ N + LKGPL TP+GKG+RSLNL LRK F L+ANVRP KS+EG KT Y+NVD+
Sbjct: 87 PAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDL 146
Query: 445 VTIRENTEGEYSGIEHEIVDGVVQSIKLITEEA 543
V IRENTEGEYSGIEH + GVVQSIKLIT +A
Sbjct: 147 VLIRENTEGEYSGIEHIVCPGVVQSIKLITRDA 179
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 179 bits (436), Expect = 3e-44
Identities = 84/143 (58%), Positives = 107/143 (74%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
K TL PG GIGPEI +V+++F AA V I+W+E V P + + SV NK
Sbjct: 45 KATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNK 104
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 474
+GLKGP+ TP+GKG+RSLNL LRKE +LYANVRPC SL G KT YD+VD++TIRENTEGE
Sbjct: 105 VGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGE 164
Query: 475 YSGIEHEIVDGVVQSIKLITEEA 543
YSG+EH++V GVV+S+K+IT +A
Sbjct: 165 YSGLEHQVVKGVVESLKIITRKA 187
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 165 bits (400), Expect = 8e-40
Identities = 76/143 (53%), Positives = 102/143 (71%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
K+TLIPG GIGPE+T A ++ EA + EWE A K IP++ +S+ +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 474
IGLKGP+ TP+G G+ S+N+ LRK F+LYANVRP ++L G+ T Y VD+V +RENTEG
Sbjct: 64 IGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTEGL 123
Query: 475 YSGIEHEIVDGVVQSIKLITEEA 543
YSGIEHE+V GVV+S+K+ITE+A
Sbjct: 124 YSGIEHEVVPGVVESLKIITEKA 146
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 152 bits (369), Expect = 4e-36
Identities = 72/140 (51%), Positives = 103/140 (73%), Gaps = 1/140 (0%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 297
VTLIPG G+G E+T +V KIFE +PI+WE +D++ + + Q+A++S+ NK+
Sbjct: 32 VTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTENV----QRAVESLKRNKV 87
Query: 298 GLKGPLMTPVGK-GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 474
GLKG TP + G+ SLN+ALRK+ D++ANV KS+ G+KT +N+D+V IRENTEGE
Sbjct: 88 GLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIRENTEGE 147
Query: 475 YSGIEHEIVDGVVQSIKLIT 534
YSG+EHE V GVV+S+K++T
Sbjct: 148 YSGLEHESVPGVVESLKIMT 167
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 151 bits (366), Expect = 1e-35
Identities = 80/166 (48%), Positives = 114/166 (68%), Gaps = 1/166 (0%)
Frame = +1
Query: 40 MAARIIRKIVPATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVD 219
+A R + A R +Y G VTLIPG G+G EIT +V+ IFEA +PI+WE ++
Sbjct: 6 IAKRTLATAAQAERTLPKKYG-GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETIN 64
Query: 220 VTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK-GYRSLNLALRKEFDLYANVRP 396
+ + D K G+ +A++S+ NKIGLKG TP + G+ SLN+ALRK+ D+YANV
Sbjct: 65 I---KQTDHKEGV-YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVAL 120
Query: 397 CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 534
KSL+G+KT ++D++ IRENTEGE+SG+EHE V GVV+S+K++T
Sbjct: 121 FKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMT 166
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 151 bits (365), Expect = 1e-35
Identities = 76/155 (49%), Positives = 108/155 (69%), Gaps = 4/155 (2%)
Frame = +1
Query: 91 AQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA--VRGPDGKFGIPQ 264
A+Y G VTLIPG GIGPE+ VAVQ IF VP+++EE++++ ++ D G
Sbjct: 45 ARYG-GRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFN 103
Query: 265 KAIDSVNANKIGLKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNV 438
+AI S+ N + +KG + TP+ G+RSLNL LR DL+AN+ CKS+ GI+T ++NV
Sbjct: 104 EAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQTRHNNV 163
Query: 439 DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEA 543
D+V IR+NTEGEYS +EHE V GV++++K+ TEEA
Sbjct: 164 DLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEA 198
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 150 bits (363), Expect = 2e-35
Identities = 74/142 (52%), Positives = 103/142 (72%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNAN 291
R VTLIPG GIGP +T AV+++ EA P+ +E +V G K +P++ I+SV N
Sbjct: 39 RTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVL---GNMRK--VPEEVIESVKRN 93
Query: 292 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 471
K+ LKG L TPVG G SLN+ LRKE D++A++ C ++ G+ T ++NVD+V IRENTEG
Sbjct: 94 KVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEG 153
Query: 472 EYSGIEHEIVDGVVQSIKLITE 537
EYSG+EHE+V GVV+S+K+IT+
Sbjct: 154 EYSGLEHEVVPGVVESLKVITK 175
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 149 bits (362), Expect = 3e-35
Identities = 74/142 (52%), Positives = 103/142 (72%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNAN 291
R VTLIPG GIGP +T AV+++ EA PI +E+ DV G + +P + ++S+ N
Sbjct: 38 RAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDV---HGEMSR--VPPEVMESIRKN 92
Query: 292 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 471
K+ LKG L TPVG G SLN+ LRKE DL+A++ C +L G+ T ++NVD+V IRENTEG
Sbjct: 93 KVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEG 152
Query: 472 EYSGIEHEIVDGVVQSIKLITE 537
EY+G+EHE+V GVV+S+K+IT+
Sbjct: 153 EYAGLEHEVVPGVVESLKVITK 174
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 138 bits (335), Expect = 6e-32
Identities = 67/146 (45%), Positives = 98/146 (67%), Gaps = 3/146 (2%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
KVTLIPG G+GPEI A +K +A V I+W+ V + + + G+P + +DS+ ANK
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWD-VQECGIEVIEAEGGVPDRVMDSIRANK 61
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY--DNVDVVTIRENTE 468
I LK P+ TP+GKG+RS+N+ LR+E LYA +RPCK+ +G++T + NVD+V +RENTE
Sbjct: 62 IALKAPITTPIGKGFRSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENTE 121
Query: 469 GEYSGIEHEI-VDGVVQSIKLITEEA 543
Y+G+E + + + IK I E A
Sbjct: 122 DLYAGVEFQAGQEKTAELIKKINEFA 147
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 135 bits (327), Expect = 5e-31
Identities = 64/129 (49%), Positives = 94/129 (72%), Gaps = 2/129 (1%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDSVNA 288
+VTLIPG GIGPE+T A+ + EA+ V +EW V+ V + K+G +P + ++S+
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEA-GVEVIE-KYGTPLPPQVLESIRE 61
Query: 289 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 468
++ +KGP+ TPVG G+RS+N+A+RKE DLYAN+RP KSL GIK+ + ++D+V +RENTE
Sbjct: 62 TRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENTE 121
Query: 469 GEYSGIEHE 495
Y+GIE E
Sbjct: 122 DLYAGIEFE 130
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 129 bits (312), Expect = 4e-29
Identities = 60/127 (47%), Positives = 83/127 (65%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
+VTLI G GIGPE+T A + + +A + EW VD A +P I++V A+
Sbjct: 5 RVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASD 64
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 474
+KGP+ TP G G RS+N+ALR+ DLYAN+RP ++L G+ + YDN+D+V +RENTE
Sbjct: 65 AAIKGPITTPAGSGIRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDL 124
Query: 475 YSGIEHE 495
YSGIE E
Sbjct: 125 YSGIEFE 131
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 126 bits (303), Expect = 4e-28
Identities = 65/146 (44%), Positives = 90/146 (61%), Gaps = 3/146 (2%)
Frame = +1
Query: 106 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG-KFGIPQKAIDSV 282
G + +T+IPG GIGPE A K+ EAAK P+ +E + A G G+PQ+ I+S+
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77
Query: 283 NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY--DNVDVVTIR 456
++ LKGPL TPVG G +S N+ LRK F+ YANVRP + + T Y +D+V +R
Sbjct: 78 RKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVR 137
Query: 457 ENTEGEYSGIEHEIVDGVVQSIKLIT 534
EN E Y+GIEH V Q++KLI+
Sbjct: 138 ENVEDLYAGIEHMQTPSVAQTLKLIS 163
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 125 bits (301), Expect = 8e-28
Identities = 66/142 (46%), Positives = 96/142 (67%), Gaps = 4/142 (2%)
Frame = +1
Query: 121 TLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIG 300
TLIPG G+GPE+ +Q++F++A VP+++E ++ V P + + I S+ NK+
Sbjct: 43 TLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVN-PVLSAKL-EDVIASIRKNKVC 100
Query: 301 LKGPLMTP----VGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 468
+KG L TP VG+ +SLN+ LR E DLYANV +SL G+KT Y ++D+V IRE TE
Sbjct: 101 IKGVLATPDYSNVGE-LQSLNMKLRNELDLYANVVHARSLPGVKTRYQDIDIVVIREQTE 159
Query: 469 GEYSGIEHEIVDGVVQSIKLIT 534
GEYS +EHE V G+V+ +K+IT
Sbjct: 160 GEYSALEHESVPGIVECLKIIT 181
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 125 bits (301), Expect = 8e-28
Identities = 66/152 (43%), Positives = 100/152 (65%), Gaps = 2/152 (1%)
Frame = +1
Query: 88 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQK 267
+A+Y G VT+IPG GIGPE+ + V+ +F A VP+++EEV V++ + +
Sbjct: 48 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDI----RN 102
Query: 268 AIDSVNANKIGLKGPLMTP--VGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVD 441
AI ++ N++ LKG + T + ++S N LR DLYANV CKSL G+ T + ++D
Sbjct: 103 AIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDID 162
Query: 442 VVTIRENTEGEYSGIEHEIVDGVVQSIKLITE 537
++ +RENTEGEYS +EHE V GVV+S+K+IT+
Sbjct: 163 ILIVRENTEGEYSSLEHESVAGVVESLKIITK 194
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 123 bits (297), Expect = 2e-27
Identities = 69/147 (46%), Positives = 92/147 (62%), Gaps = 2/147 (1%)
Frame = +1
Query: 106 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVT-AVRGPDGKFGIPQKAIDSV 282
G VT++PG GIGPE+ V+++F A VP+++E VD+ A G D + AI S+
Sbjct: 48 GRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVVDIDPASEGNDDL----EYAITSI 103
Query: 283 NANKIGLKGPLMTPV-GKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRE 459
N + LKG + T G S N+ALR E DLY NV CKS I + NVDVV IR+
Sbjct: 104 KRNGVALKGNIETKSEATGIISRNVALRNELDLYVNVLHCKSFNAIPAHHQNVDVVIIRQ 163
Query: 460 NTEGEYSGIEHEIVDGVVQSIKLITEE 540
NTEGEY+ +EHE V GVV+S+K++T E
Sbjct: 164 NTEGEYAMLEHESVRGVVESMKVVTVE 190
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 118 bits (285), Expect = 7e-26
Identities = 59/141 (41%), Positives = 96/141 (68%), Gaps = 2/141 (1%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 297
VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+ NK+
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKV 109
Query: 298 GLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 471
+ G + TP+ KG S ++ LR++ DL+ANV KSL G T ++N+D+V IRE TEG
Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
Query: 472 EYSGIEHEIVDGVVQSIKLIT 534
EYS +EHE GV++ +K++T
Sbjct: 170 EYSSLEHESARGVIECLKIVT 190
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 118 bits (284), Expect = 9e-26
Identities = 67/163 (41%), Positives = 98/163 (60%), Gaps = 1/163 (0%)
Frame = +1
Query: 55 IRKIVPATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR 234
++K V T +AQY G VT++PG GIGPE+ V++IF PI++E +D+
Sbjct: 40 LQKKVTGTDIPSAQYG-GRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDP-- 96
Query: 235 GPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYR-SLNLALRKEFDLYANVRPCKSLE 411
+G + AI S+ N + LKG + T S N+A+R E DLY NV CKS
Sbjct: 97 STEGNDDLDY-AITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELDLYVNVVHCKSYP 155
Query: 412 GIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEE 540
GI + ++DVV IR+NT+GEY+ +EHE V G+V+S+K++T E
Sbjct: 156 GIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVE 198
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 114 bits (275), Expect = 1e-24
Identities = 60/132 (45%), Positives = 82/132 (62%), Gaps = 2/132 (1%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWE--EVDVTAVRGPDGKFGIPQKAIDSVNAN 291
VTLIPG GIGPEI V ++F+A P WE + V A+ G +PQ +DS+
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALE-KSGDL-LPQTTLDSIGRT 69
Query: 292 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 471
+ LKGPL TP+G G+RS+N+ LR+ F LYANVRP +++ Y+ +D+V +REN EG
Sbjct: 70 GLALKGPLSTPIGGGFRSVNVRLRETFQLYANVRPARTIVP-GGRYEKIDLVLVRENLEG 128
Query: 472 EYSGIEHEIVDG 507
Y G EH + G
Sbjct: 129 LYVGHEHYVPIG 140
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 111 bits (266), Expect = 1e-23
Identities = 61/154 (39%), Positives = 90/154 (58%)
Frame = +1
Query: 73 ATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF 252
A AG+ + KVTLI G G+G E+ AVQ++ A K PIEW+ D + D
Sbjct: 57 AKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDD-- 114
Query: 253 GIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYD 432
+ + + S+ ANK+G+KGP+ + R +RK+F +A V C +EG+ + Y
Sbjct: 115 -VSPEVLKSLRANKVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYG 167
Query: 433 NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 534
+ DVV IR+ EG+YSGIEH +V GV+Q+IK+ T
Sbjct: 168 DFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVST 201
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 109 bits (262), Expect = 4e-23
Identities = 56/135 (41%), Positives = 90/135 (66%), Gaps = 2/135 (1%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 297
VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+ NK+
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKV 109
Query: 298 GLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 471
+ G + TP+ KG S ++ LR++ DL+ANV KSL G T ++N+D+V IRE TEG
Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
Query: 472 EYSGIEHEIVDGVVQ 516
EYS +EHE + V +
Sbjct: 170 EYSSLEHECCEEVAE 184
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 107 bits (257), Expect = 2e-22
Identities = 57/144 (39%), Positives = 86/144 (59%), Gaps = 2/144 (1%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR-GPDGKFGIPQKAIDSVNANK 294
+T+ G G+GPEI AV I + A+ + E VD+ + + GI A +S++ +
Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTR 69
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKS-LEGIKTLYDNVDVVTIRENTEG 471
+ LK P MTP G G++SLN+ALR+ LY NVRPC S + T + ++DVV IREN E
Sbjct: 70 LLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEED 129
Query: 472 EYSGIEHEIVDGVVQSIKLITEEA 543
YSG+EH++ + + +K+ T A
Sbjct: 130 TYSGVEHKLSEDTHECVKISTRSA 153
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 103 bits (248), Expect = 2e-21
Identities = 58/141 (41%), Positives = 79/141 (56%), Gaps = 2/141 (1%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANK 294
VT+ G GIGPEI AV + + A VP+ E +++ + +GI + + K
Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTK 66
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRP-CKSLEGIKTLYDNVDVVTIRENTEG 471
LKGP+ TP G GY+SLN+ LRK LYANVRP C + T +DVV IREN E
Sbjct: 67 ALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENEED 126
Query: 472 EYSGIEHEIVDGVVQSIKLIT 534
Y+GIE+ +S+KLI+
Sbjct: 127 LYAGIEYHHTADTYESVKLIS 147
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 103 bits (248), Expect = 2e-21
Identities = 56/148 (37%), Positives = 84/148 (56%), Gaps = 7/148 (4%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVP----IEWEEVDVTAVRGPDGKFGIPQKAIDSVN 285
+ +I G GIG ++ A QK+ +AA I W V +P+ + ++
Sbjct: 76 IPIIHGDGIGTDVGPAAQKVLDAAAEATGRSIAWMRVYAGGSARDMYDENLPEDTVSAIR 135
Query: 286 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVVTIR 456
+++ +KGPL TPVG G+RSLN+ALRK DLYANVRP L+G+ + N +D++T R
Sbjct: 136 DHRVAIKGPLTTPVGAGFRSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKMDMITFR 195
Query: 457 ENTEGEYSGIEHEIVDGVVQSIKLITEE 540
ENTE Y+GIE E V+ ++ E+
Sbjct: 196 ENTEDVYAGIEWEAGTDEVEQVRDFLED 223
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 99 bits (238), Expect = 3e-20
Identities = 59/146 (40%), Positives = 83/146 (56%), Gaps = 4/146 (2%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVA----VQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVN 285
V LI G GIGPEI + KI E +PIE+ EV+ +P+ ++ ++
Sbjct: 5 VALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKIID 64
Query: 286 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 465
I LKGP VG+ + + LR+ +D+YAN+RP KS+ GI T Y NVD++ +RENT
Sbjct: 65 KADIILKGP----VGESAADVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENT 120
Query: 466 EGEYSGIEHEIVDGVVQSIKLITEEA 543
E Y G EH + DGV +K+IT A
Sbjct: 121 EDLYKGFEHIVSDGVAVGMKIITRFA 146
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 95.1 bits (226), Expect = 9e-19
Identities = 54/141 (38%), Positives = 81/141 (57%), Gaps = 2/141 (1%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANK 294
+T+ G GIGPEI AV I A+ I E ++V + GI +++ +S+
Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-KTLYDNVDVVTIRENTEG 471
I LK P+ TP G GY+SLN+ +RK L+AN+RP S TL+ ++++ IREN E
Sbjct: 67 IILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENEED 126
Query: 472 EYSGIEHEIVDGVVQSIKLIT 534
Y+GIE+ + +SIKLI+
Sbjct: 127 LYAGIEYRQTHNMYESIKLIS 147
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 91.1 bits (216), Expect = 2e-17
Identities = 51/134 (38%), Positives = 79/134 (58%), Gaps = 10/134 (7%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFGIPQKAID 276
+ I G GIGP+I A ++ +AA + IEW+EV + +PQ+ ++
Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLE 80
Query: 277 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDVV 447
++ I +KGPL TP+G G RSLN+ALR+E DL+ +RP + +G+ + ++VD+V
Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140
Query: 448 TIRENTEGEYSGIE 489
RENTE Y+GIE
Sbjct: 141 IFRENTEDIYAGIE 154
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 90.6 bits (215), Expect = 2e-17
Identities = 62/170 (36%), Positives = 90/170 (52%), Gaps = 13/170 (7%)
Frame = +1
Query: 61 KIVPATRAGAAQYSTG---VRKVTLIP---GHGIGPEITVAVQKIFEAAKVPIEWEEVDV 222
K+ P +Y G V +IP G GIG ++ A ++ +AA I E V
Sbjct: 5 KVKPPENGEKIRYENGKLIVPDNPIIPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWF 64
Query: 223 TAVRGPDGK--FG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANV 390
G D +G +P ++++ ++ LKGPL TPVG GYRSLN+ +R+ DLYANV
Sbjct: 65 QVYAGEDAYKLYGNYLPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIRQVLDLYANV 124
Query: 391 RPCKSLEGIKTLY---DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 531
RP L+G+ + + V+ V RENTE Y+GIE G +++KLI
Sbjct: 125 RPVYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWP--RGSEEALKLI 172
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 89.8 bits (213), Expect = 4e-17
Identities = 51/127 (40%), Positives = 78/127 (61%), Gaps = 8/127 (6%)
Frame = +1
Query: 133 GHGIGPEITVAVQKIFEAA----KVPIEWEEVDVTAVRGPDGKFG-IPQKAIDSVNANKI 297
G GIGPEI A +K+ +AA K I W+E+ + R + K P+++I ++N ++
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEI-LLGDRAEELKGDRFPEESIKAINDYRV 82
Query: 298 GLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVVTIRENTE 468
LK PL TPVGKG++S+N+ +R DLYAN+RP K + G+++ N V++ RENT+
Sbjct: 83 LLKAPLNTPVGKGFKSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTD 142
Query: 469 GEYSGIE 489
Y G E
Sbjct: 143 DLYLGYE 149
>UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=3; Aquificaceae|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Aquifex aeolicus
Length = 426
Score = 88.2 bits (209), Expect = 1e-16
Identities = 58/137 (42%), Positives = 80/137 (58%), Gaps = 13/137 (9%)
Frame = +1
Query: 118 VTLIPGHGIGPEIT--------VAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQK 267
+ I G GIGPEIT AV+K + +K I W V++ A + K G +PQ+
Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSK-KIYW--VELLAGDKAEEKTGERLPQE 97
Query: 268 AIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---V 438
+D + + +G+KGPL TPVGKG RS+N ALR+ FD Y+ VRP + G T N V
Sbjct: 98 TLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPNPERV 156
Query: 439 DVVTIRENTEGEYSGIE 489
D+V RENT+ Y+G+E
Sbjct: 157 DLVVFRENTDDVYAGVE 173
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 87.4 bits (207), Expect = 2e-16
Identities = 50/146 (34%), Positives = 81/146 (55%), Gaps = 1/146 (0%)
Frame = +1
Query: 109 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVN 285
+ K+ +I G GIG E+ A ++ EA +P E+ + V GK +P++ I++
Sbjct: 1 MHKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGK-ALPEETIETA- 58
Query: 286 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 465
+ L G+ + + LR D YAN+RP K+ +G+K L ++D V +RENT
Sbjct: 59 ---LDCDAVLFGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENT 115
Query: 466 EGEYSGIEHEIVDGVVQSIKLITEEA 543
EG Y GIE EI +G+ + ++ITE+A
Sbjct: 116 EGLYKGIEAEIDEGITIATRVITEKA 141
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 85.4 bits (202), Expect = 8e-16
Identities = 49/145 (33%), Positives = 77/145 (53%)
Frame = +1
Query: 109 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNA 288
++K+ +IPG GIG E+ A I E +P E+ D +P + +++
Sbjct: 1 MKKIVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRK 60
Query: 289 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 468
+ L G G+ + + LR+E +ANVRP K++EGI+ LY +D+V +RENTE
Sbjct: 61 SDAVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTE 116
Query: 469 GEYSGIEHEIVDGVVQSIKLITEEA 543
Y G E D V ++I++IT EA
Sbjct: 117 CLYMGFEFGFGD-VTEAIRVITREA 140
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 85.0 bits (201), Expect = 1e-15
Identities = 56/154 (36%), Positives = 84/154 (54%), Gaps = 13/154 (8%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDV--TAVRGPDGKFGIPQKA 270
+ I G GIG +I+ + K+ +AA + I W EV A + D +PQ+
Sbjct: 31 IPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQET 90
Query: 271 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVD 441
+D+V + +KGPL TPVG G RSLN+ALR++ DLY +RP + EG+ + +VD
Sbjct: 91 LDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVD 150
Query: 442 VVTIRENTEGEYSGIEHEI-VDGVVQSIKLITEE 540
+ REN+E Y+GIE + + IK + EE
Sbjct: 151 MTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEE 184
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 84.6 bits (200), Expect = 1e-15
Identities = 52/150 (34%), Positives = 84/150 (56%), Gaps = 12/150 (8%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEV--DVTAVRGPDGKFGIPQKA 270
+ I G G+G ++ ++ I + A K I W +V A + DG + PQ+
Sbjct: 31 IAYINGDGVGQDVMPVMRNIVDCAIKHCYKNKRKIHWMQVFNGEQAAKLYDGDW-FPQET 89
Query: 271 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VD 441
I +V A KI +KGPL TP+G G+RSLN+ALR+E DL+ N+R K + + N +
Sbjct: 90 IQAVRACKIAIKGPLTTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPFLTN 149
Query: 442 VVTIRENTEGEYSGIEHEIVDGVVQSIKLI 531
+ +R+++E YSGIE + G ++S K++
Sbjct: 150 ITVLRDSSEDVYSGIEWQA--GSIESEKML 177
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 84.6 bits (200), Expect = 1e-15
Identities = 49/147 (33%), Positives = 81/147 (55%), Gaps = 3/147 (2%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPD--GKFGIPQKAIDSVN 285
+ +I G G+GPE+ A+ K+ AA +E+ + A + G +P + ++
Sbjct: 3 KTAAVIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVPDETWQILD 62
Query: 286 ANKIGLKGPLMTPVGKGY-RSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIREN 462
++ KGP TP G G RS+ +++R+++DLYANVRP K+ +V++V +RE
Sbjct: 63 SSDACFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREG 122
Query: 463 TEGEYSGIEHEIVDGVVQSIKLITEEA 543
TEG Y G E ++ D V +I+ IT A
Sbjct: 123 TEGLYIGEEIQLTDDVSIAIRKITRTA 149
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 83.8 bits (198), Expect = 2e-15
Identities = 48/128 (37%), Positives = 74/128 (57%), Gaps = 2/128 (1%)
Frame = +1
Query: 91 AQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKA 270
A+Y G VTLIPG GIGPE+ V+++F + VP+++E V V + + A
Sbjct: 45 AKYG-GRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSEDDIS---NA 100
Query: 271 IDSVNANKIGLKGPLMT--PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDV 444
I ++ N + LKG + T + ++S N LR DLYANV C+SL G++T + N+D+
Sbjct: 101 IMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDI 160
Query: 445 VTIRENTE 468
+ I E +E
Sbjct: 161 IIILEKSE 168
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 81.8 bits (193), Expect = 9e-15
Identities = 48/135 (35%), Positives = 75/135 (55%), Gaps = 10/135 (7%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFGIPQKAID 276
+ + G G GP+I A ++F+AA + + W EV +P + ++
Sbjct: 29 IPYVEGDGTGPDIWRASVRVFDAAVERAYGGRRKLMWYEVLAGEKAFNLTGNWLPDETVE 88
Query: 277 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDVV 447
+ +G+KGPL TPVG+G RSLN+ALR+ DLY +RP + +G+ + + VD+V
Sbjct: 89 AFRQYLVGIKGPLTTPVGRGIRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMV 148
Query: 448 TIRENTEGEYSGIEH 492
RENTE Y+GIE+
Sbjct: 149 IFRENTEDIYAGIEY 163
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 81.8 bits (193), Expect = 9e-15
Identities = 45/129 (34%), Positives = 76/129 (58%)
Frame = +1
Query: 142 IGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMT 321
I +T AV ++ +A + P+ +E ++G + + + +DS+ NK+ L G +
Sbjct: 8 IDSNVTNAVHQVMDAMQAPVYFETY---IIKGKNMNH-LTWEVVDSIRKNKVCLNGRVNN 63
Query: 322 PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIV 501
+ G RKE DL+A++ C +L G + ++NVD+V IRENTEGEY+G EHE+V
Sbjct: 64 SLCGG-------ARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVV 116
Query: 502 DGVVQSIKL 528
GV++S ++
Sbjct: 117 PGVIESFQV 125
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 81.0 bits (191), Expect = 2e-14
Identities = 48/143 (33%), Positives = 74/143 (51%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
K+ +IPG GIG E+ A I + +E+ D +P++ +++V +
Sbjct: 5 KIAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEAR 64
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 474
L G G+ + + LR+EFDL+AN+RP KSL G+ LY ++D V +RENTE
Sbjct: 65 ATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDL 120
Query: 475 YSGIEHEIVDGVVQSIKLITEEA 543
Y G E +G V ++IT A
Sbjct: 121 YVGDEEYTPEGAVAK-RIITRTA 142
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 80.6 bits (190), Expect = 2e-14
Identities = 49/145 (33%), Positives = 82/145 (56%), Gaps = 2/145 (1%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAI--DSVNA 288
K++LI G GIGPE++ + + E ++ + +T + D KA+ D+V+A
Sbjct: 3 KISLITGDGIGPELSDSAVSVLETIHDKLDLK-FGITKLSAGDKALEQTGKALPDDTVSA 61
Query: 289 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 468
K + PVG+ + + LR+ DLYAN+RP KS + L D++D+V +RENTE
Sbjct: 62 IKQS-DACMKAPVGESAADVIVVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVRENTE 120
Query: 469 GEYSGIEHEIVDGVVQSIKLITEEA 543
Y+G E + D V ++++I+E+A
Sbjct: 121 DLYTGKEFSLGDSSV-ALRIISEQA 144
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 80.6 bits (190), Expect = 2e-14
Identities = 55/157 (35%), Positives = 88/157 (56%), Gaps = 19/157 (12%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAV----------RGPDG 246
+ I G GIG +IT A+ K+ ++A + I W EV V P+
Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91
Query: 247 KFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL 426
++ +P I+++N K+ +KGPL TP+G+G+RSLN+ALR++ DLY +RP + +
Sbjct: 92 QWLLPD-TIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPV 150
Query: 427 YD--NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 531
+ VD+V REN+E Y+GIE + +G ++ KLI
Sbjct: 151 KEPQKVDMVIFRENSEDIYAGIEWQ--EGSAEAKKLI 185
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 79.8 bits (188), Expect = 4e-14
Identities = 50/143 (34%), Positives = 75/143 (52%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
K+ ++PG GIG E+ ++ + A E+ V+V R + +++V A
Sbjct: 2 KIAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKACD 61
Query: 295 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 474
L G + +P GK YRS+ L LRKE DLYAN+RP +S V+ REN+E
Sbjct: 62 CVLFGAITSPPGKPYRSIILTLRKELDLYANIRPFRS---CPISPRKVNFTIYRENSEDL 118
Query: 475 YSGIEHEIVDGVVQSIKLITEEA 543
Y GIE EI +S+++IT +A
Sbjct: 119 YMGIE-EITGDEARSVRVITRKA 140
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 79.8 bits (188), Expect = 4e-14
Identities = 55/154 (35%), Positives = 81/154 (52%), Gaps = 13/154 (8%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA--KVPIEWEEVDVTAVRGPD------GKFGI-PQKA 270
+ I G G G +I A + + AA K EE++ V D G + I P+
Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDT 88
Query: 271 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVD 441
+ ++ + +KGPL TPVG G RSLN+ALR+ FDLY VRPC+ G + + + +D
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKLD 148
Query: 442 VVTIRENTEGEYSGIE-HEIVDGVVQSIKLITEE 540
++ RENTE Y GIE E +G + I + +E
Sbjct: 149 IIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDE 182
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 77.4 bits (182), Expect = 2e-13
Identities = 50/131 (38%), Positives = 76/131 (58%), Gaps = 6/131 (4%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVA----VQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDS 279
V +I G GIGPE+ A ++KI E K+P+E+ V V A K+G +P+++ +
Sbjct: 4 VAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEF--VFVEAGDRAKEKYGEALPKESYER 61
Query: 280 VNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRE 459
+ LKGP VG+ + + LR+E DL+AN+RP K L G+ L +NVD++ +RE
Sbjct: 62 LLRADAILKGP----VGETAADVIVRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRE 117
Query: 460 NTEGEYSGIEH 492
N E Y G E+
Sbjct: 118 NIEDLYVGAEN 128
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 77.0 bits (181), Expect = 3e-13
Identities = 47/157 (29%), Positives = 78/157 (49%), Gaps = 14/157 (8%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
++ ++ G+GIGPEIT A ++ EA + EW+ + + +P + I + K
Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVK 61
Query: 295 IGLKGPLMTPVGKG-------------YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN 435
+K PL+ G Y S+N A+R+E +L+ N RP + GI ++
Sbjct: 62 FCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEK 121
Query: 436 VDVVTIRENTEGEYSGIEHEIVDG-VVQSIKLITEEA 543
+D+V +RE TE Y G E + DG ++IK +T A
Sbjct: 122 MDMVIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSA 158
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 76.6 bits (180), Expect = 3e-13
Identities = 52/152 (34%), Positives = 82/152 (53%), Gaps = 14/152 (9%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEV----DVTAVRGPDGKFGIPQ 264
+ I G GIG ++T A++ + +AA K I W E+ V G + +P
Sbjct: 29 IPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGKRKISWMEIYAGGKANEVYGENT--WLPD 86
Query: 265 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--- 435
+ + + + +KGPLMTPVG G RSLN+A+R+ DLY +RP + +G + +
Sbjct: 87 ETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPEL 146
Query: 436 VDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 531
VD+V REN+E Y+G+E V G ++ K+I
Sbjct: 147 VDMVIFRENSEDIYAGVEW--VAGSAEANKVI 176
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 75.8 bits (178), Expect = 6e-13
Identities = 40/107 (37%), Positives = 69/107 (64%), Gaps = 2/107 (1%)
Frame = +1
Query: 106 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVN 285
G VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMK 73
Query: 286 ANKIGLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIK 420
NK+ + G + TP+ KG S ++ LR++ DL+ANV KSL G++
Sbjct: 74 ENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVIHVKSLPGVQ 120
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 74.5 bits (175), Expect = 1e-12
Identities = 48/146 (32%), Positives = 74/146 (50%), Gaps = 3/146 (2%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
++ LI G GIG E+ A +++ EAA E+ + D +P+ D+V
Sbjct: 5 RICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVPEATYDAVENTD 64
Query: 295 IGLKGPLMTPVGK---GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 465
L G +P G+ G+ LR++++LYANVRP K+ + Y+NVD+V +RENT
Sbjct: 65 ATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKT-RPVPHSYENVDLVIVRENT 123
Query: 466 EGEYSGIEHEIVDGVVQSIKLITEEA 543
+G Y E D + +IT EA
Sbjct: 124 QGLYVEQERRYGDTAIAD-TVITREA 148
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 70.9 bits (166), Expect = 2e-11
Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 5/148 (3%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR----GPDGKFGIPQKAIDS 279
+K ++ G GIGPE+ ++ ++ + E + + + G IP +
Sbjct: 3 KKAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKI 62
Query: 280 VNANKIGLKGPLMT-PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 456
+ KGP T PV RS+ + LR++FDLYAN+RP K+ + + T +D V R
Sbjct: 63 LEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFR 121
Query: 457 ENTEGEYSGIEHEIVDGVVQSIKLITEE 540
E TEG Y+G+E +I D +I+ IT +
Sbjct: 122 EATEGLYTGVEAKITDDAAIAIRKITRQ 149
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 67.7 bits (158), Expect = 2e-10
Identities = 41/131 (31%), Positives = 70/131 (53%), Gaps = 9/131 (6%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVP-----IEWEEVDVTAVRGPDGKFGIPQKAIDS 279
++ ++ G GIG EI A Q++ AA V ++W E+ + IP + +
Sbjct: 12 RIGVLLGDGIGHEIVPATQRVVSAAVVAAGGGAVDWVELPLGLGAIESHGTPIPDSTLSA 71
Query: 280 VNANKIGLKGPLMTPVG----KGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVV 447
++A + GP + +G + +RK FDL+AN+RP +SLEG+ + ++D+V
Sbjct: 72 LDALDAWILGPHDSAAYPEPFRGRLTPGGVVRKRFDLFANIRPARSLEGVASTVPDMDLV 131
Query: 448 TIRENTEGEYS 480
+RENTEG Y+
Sbjct: 132 IVRENTEGLYA 142
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 67.3 bits (157), Expect = 2e-10
Identities = 57/157 (36%), Positives = 82/157 (52%), Gaps = 13/157 (8%)
Frame = +1
Query: 73 ATRAGAAQ--YSTGVRK---VTLIPGHGIGPEITVAVQKIFE--AAKVPIEWEEVDVTA- 228
ATR A + S RK + LIPG GIG E+ A +++ E +K + + +D+ A
Sbjct: 6 ATRLSACRGLASNAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAG 65
Query: 229 --VRGPDGKFGIPQKAIDSVNANKIG-LKGPLMTPVGK--GYRSLNLALRKEFDLYANVR 393
GK +P + + + G L G + +P K GY S +ALR+E L+ANVR
Sbjct: 66 FQTFQETGK-ALPDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVR 124
Query: 394 PCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVD 504
P KS+EG K +D+V +RENTE Y IE +D
Sbjct: 125 PVKSVEGEKG--KPIDMVIVRENTEDLYIKIEKTYID 159
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 66.1 bits (154), Expect = 5e-10
Identities = 48/148 (32%), Positives = 68/148 (45%), Gaps = 6/148 (4%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 297
+ +IPG GIG E+ A + A +P +E D +P + + A
Sbjct: 8 ILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADA 67
Query: 298 GLKGPLMTP--VGKGYRSLNLALRKEFDLYANVRPC---KSLEGIKTLYDNVDVVTIREN 462
L G + +P GYRS + LR+E DLYAN+RP G VD+V +REN
Sbjct: 68 ILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVREN 127
Query: 463 TEGEYSGIEHEIVDGVVQ-SIKLITEEA 543
TE Y+G E DG + ++IT A
Sbjct: 128 TEDVYAGRERVEDDGATAIAERVITRRA 155
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 65.3 bits (152), Expect = 9e-10
Identities = 46/102 (45%), Positives = 54/102 (52%)
Frame = -3
Query: 419 LIPSKLLQGLTLAYKSNSFLRAKLSDL*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPS 240
L P L A SNSFL A +DL P GV + PF P L F +S A P S
Sbjct: 7 LTPGMFLIKTNEAKISNSFLNATFNDLPDDPVGVNKIPFNPTLFLFNDSTAS-ATPVPLS 65
Query: 239 GPLTAVTSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVTL 114
P TST SHS+GT + K+ T +VIS PIP PGM VT+
Sbjct: 66 KP---ETSTVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTV 104
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 64.9 bits (151), Expect = 1e-09
Identities = 44/130 (33%), Positives = 71/130 (54%), Gaps = 11/130 (8%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 282
K+ ++ G IG EI A ++ AA + I+W +V + A +P+ ++++
Sbjct: 7 KLGILNGDDIGHEIVPASVEVARAAAGKAGLGIDWTDVPIGAAALESHGHTMPEGTMETL 66
Query: 283 NANKIGLKGPLMTPVG-KGYRSLNLA------LRKEFDLYANVRPCKSLEGIKTLYDNVD 441
GL G ++ P+G + Y + A LRK FDL+ANVRP +S GI L+D++D
Sbjct: 67 E----GLDGWILGPIGHRDYPKVPGAINPHPILRKGFDLFANVRPTRSYPGIGCLFDDID 122
Query: 442 VVTIRENTEG 471
+V +REN EG
Sbjct: 123 LVIVRENNEG 132
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 64.5 bits (150), Expect = 2e-09
Identities = 28/60 (46%), Positives = 43/60 (71%)
Frame = +1
Query: 358 LRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITE 537
L DLYA+V K+L ++T + +VD++ + ENTEGEYS +EHE V GV +S+K++T+
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 63.3 bits (147), Expect = 3e-09
Identities = 43/129 (33%), Positives = 65/129 (50%), Gaps = 5/129 (3%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
K+ +IPG GIG E+ +K+F++ +PI+ + VD +P ID V
Sbjct: 12 KIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQYD 71
Query: 295 IGLKGPLMTP-VGKGYRSLN--LALRKEFDLYANVRPCKSLEGIKTLYD--NVDVVTIRE 459
L G L P Y +L + +R++ D + +RP K GI T +DV+ +RE
Sbjct: 72 AILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVVRE 131
Query: 460 NTEGEYSGI 486
N+EGEYS I
Sbjct: 132 NSEGEYSNI 140
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 63.3 bits (147), Expect = 3e-09
Identities = 46/141 (32%), Positives = 66/141 (46%), Gaps = 13/141 (9%)
Frame = +1
Query: 100 STGVRKVTLIPGHGIGPEITVAVQKIFEAAK---VPIEWEEVDVTAVRGPDGKFGIPQKA 270
++G ++ +IPG GIGPE+T K+ E A V E D+ A R +P
Sbjct: 128 TSGSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLPDSV 187
Query: 271 IDSVNANKIGLKGPL-------MTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY 429
++ + + L G + P G R L L LR E D Y N+RP + G+ +
Sbjct: 188 LEEIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPL 247
Query: 430 DN---VDVVTIRENTEGEYSG 483
N VD V +RE TEG Y+G
Sbjct: 248 ANPGEVDFVVVREGTEGPYTG 268
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 63.3 bits (147), Expect = 3e-09
Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 9/132 (6%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRG-PDGKFGIPQ-----KAID 276
K+ +I G GIGPE+T K+ A + IE ++D+ A R +G+ + + D
Sbjct: 2 KLAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREHD 61
Query: 277 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVV 447
++ IG G + P G R L L LR D + N+RP K EG+++ N +D V
Sbjct: 62 AILLGAIGAPGSV--PPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFV 119
Query: 448 TIRENTEGEYSG 483
+RE TEG Y+G
Sbjct: 120 VVREGTEGAYTG 131
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 62.5 bits (145), Expect = 6e-09
Identities = 49/152 (32%), Positives = 74/152 (48%), Gaps = 14/152 (9%)
Frame = +1
Query: 127 IPGHGIGPEIT-VAVQKIFEAAKVPIEWEEVDVTAVRGPD------GKFGIPQKAIDSVN 285
+ G GIGP IT A++ + + +E +V+ + G +P A+D++
Sbjct: 21 VDGDGIGPYITGEAIRVLQSLLRDELERGDVEFRKIEGLSIEERARAMKALPDDALDALK 80
Query: 286 ANKIGLKGPLMTPVGKG-----YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVT 450
+ LKGPL TP KG S N+A+R+E DL+ANVRP + + +D V
Sbjct: 81 KCHVILKGPLTTPK-KGDPWPNLESANVAMRRELDLFANVRP------VSIPSEGIDWVF 133
Query: 451 IRENTEGEY--SGIEHEIVDGVVQSIKLITEE 540
RENTEGEY + D + K+IT +
Sbjct: 134 FRENTEGEYVLGSKGFNVTDDLAVDFKVITTQ 165
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 62.1 bits (144), Expect = 8e-09
Identities = 48/141 (34%), Positives = 70/141 (49%), Gaps = 8/141 (5%)
Frame = +1
Query: 82 AGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRGPDGK-FG 255
A A Q+ V ++ ++PG GIGPEIT A + AA + ++ AV K FG
Sbjct: 3 APALQFWGNVMQLIVLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQFG 62
Query: 256 --IPQKAIDSVNANKIGLKGPLMTPVGK--GYRSLNLA--LRKEFDLYANVRPCKSLEGI 417
+ + +D V + GP T K + +N + RK DLYANVRP ++ G
Sbjct: 63 TTVRPELLDIVRGADGLILGPTATFDFKDEAHGEINPSRHFRKNLDLYANVRPARTYAGR 122
Query: 418 KTLYDNVDVVTIRENTEGEYS 480
+ D+V +RENTEG Y+
Sbjct: 123 PGRLGDFDLVVVRENTEGFYA 143
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 61.3 bits (142), Expect = 1e-08
Identities = 35/100 (35%), Positives = 60/100 (60%), Gaps = 2/100 (2%)
Frame = +1
Query: 247 KFG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK 420
K+G +PQ+A+ +A + KGP +G+ + +R + LYAN+RP K+L G+
Sbjct: 15 KYGTAMPQEALRLADAADVIFKGP----IGESAYDVTSLIRMRYTLYANIRPVKNLPGVP 70
Query: 421 TLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEE 540
+ + +D V +REN E Y G E+++ D V ++K+ITE+
Sbjct: 71 AVRE-IDCVFVRENVEDVYVGAEYKVGD-VAIALKVITEK 108
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 56.4 bits (130), Expect = 4e-07
Identities = 46/146 (31%), Positives = 64/146 (43%), Gaps = 9/146 (6%)
Frame = +1
Query: 76 TRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV----TAVRGPD 243
T + A T V + +IPG GIGPE+ + +A + + +D T +R +
Sbjct: 8 TCSARAGSETAVTTIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGE 67
Query: 244 GKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSL-EGIK 420
G I S A +G G R + LR E DLY N RP + + +
Sbjct: 68 ALTGSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLS 127
Query: 421 TLYDN----VDVVTIRENTEGEYSGI 486
L D +D V +RENTEG YSGI
Sbjct: 128 PLRDPARRAIDCVIVRENTEGLYSGI 153
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 56.4 bits (130), Expect = 4e-07
Identities = 45/146 (30%), Positives = 68/146 (46%), Gaps = 10/146 (6%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 282
++ +IPG GIG E+ ++K+ E ++V E++E A +P AI+
Sbjct: 4 RIAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIEEF 63
Query: 283 ---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDV 444
+A G G G R + L +R E DLY N+RP K T + +D+
Sbjct: 64 KKFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDI 123
Query: 445 VTIRENTEGEYSGIEHEIVDGVVQSI 522
V +RENTEG Y+G + G Q I
Sbjct: 124 VFVRENTEGLYAGAGGFLRKGTPQEI 149
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 54.8 bits (126), Expect = 1e-06
Identities = 23/55 (41%), Positives = 40/55 (72%)
Frame = +1
Query: 373 DLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITE 537
DL ANV +S ++T + N+D++ +R+NTEGEYS +E E ++ VV+S++ +T+
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTK 71
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 54.8 bits (126), Expect = 1e-06
Identities = 46/153 (30%), Positives = 69/153 (45%), Gaps = 17/153 (11%)
Frame = +1
Query: 100 STGVRKVTLIPGHGIGPEITV-------AVQKIF--EAAKVPIEWEEVDVTAVRG---PD 243
S V ++ +IPG GIG E+ AV + F A PIEW D A G PD
Sbjct: 2 SEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPD 61
Query: 244 GKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT 423
+ +D++ +G P P + R+EFD Y N+RP + +G+
Sbjct: 62 D-WKTQLSGMDALLFGAVGW--PETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPC 118
Query: 424 LY-----DNVDVVTIRENTEGEYSGIEHEIVDG 507
++D + +RENTEGEYS + + +G
Sbjct: 119 PLAGRKAGDIDFMIVRENTEGEYSAVGGTMFEG 151
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 54.8 bits (126), Expect = 1e-06
Identities = 43/125 (34%), Positives = 61/125 (48%), Gaps = 3/125 (2%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
+V +I G GIGPE+ + ++ + I + E + + G P D K
Sbjct: 3 RVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFE--GGFEVFKRIGSPISEDDLKEIRK 60
Query: 295 IG--LKGPLMTPVG-KGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 465
+ L G TP GYRSL + LRKE DLYAN+R I L + ++V +RENT
Sbjct: 61 MDAILFGATTTPFNVPGYRSLIVTLRKELDLYANLRI------IPDLSNGKEIVIVRENT 114
Query: 466 EGEYS 480
EG Y+
Sbjct: 115 EGLYA 119
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 54.4 bits (125), Expect = 2e-06
Identities = 48/136 (35%), Positives = 65/136 (47%), Gaps = 13/136 (9%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPI-EWEEVDVTAVRGPD--GKFGI--PQKAIDS 279
K+ IP GIGPE+ A ++ EA + +++ T G D K G+ P +D
Sbjct: 5 KIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPADGLDK 64
Query: 280 V---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN----- 435
+ +A G G P L L + + FD YANVRP K L GI N
Sbjct: 65 LKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGPGD 124
Query: 436 VDVVTIRENTEGEYSG 483
+D V +REN+EGEYSG
Sbjct: 125 LDWVIVRENSEGEYSG 140
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 54.0 bits (124), Expect = 2e-06
Identities = 24/33 (72%), Positives = 28/33 (84%)
Frame = +1
Query: 106 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIE 204
GV+ VTLIPG GIGPEI+ AV KIF+AAK PI+
Sbjct: 3 GVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQ 35
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 53.6 bits (123), Expect = 3e-06
Identities = 53/146 (36%), Positives = 73/146 (50%), Gaps = 21/146 (14%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG-----KFG--IPQKAI 273
KV +I G GIG E+ I EA K+ E E ++ ++G G K+G +P+ I
Sbjct: 3 KVCVIEGDGIGKEV------IPEAIKILNELGEFEI--IKGEAGLECLKKYGNALPEDTI 54
Query: 274 DSVNANKIGLKGPLMTPVG---KGYRSLNLALRKEFDLYANVRPCKSLEGIKTL------ 426
+ I L G + +P + Y+S + LRK F LYANVRP + GI L
Sbjct: 55 EKAKEADIILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIAD 113
Query: 427 YD-----NVDVVTIRENTEGEYSGIE 489
Y+ N+D+V IRENTE Y G E
Sbjct: 114 YEFLNAKNIDIVIIRENTEDLYVGRE 139
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 52.4 bits (120), Expect = 7e-06
Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 15/156 (9%)
Frame = +1
Query: 100 STGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDS 279
ST K+ ++PG GIG E+T A +FE VP+ D+ IP +
Sbjct: 3 STDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAAIPSRTWQL 62
Query: 280 VNANKIGLKGPLMT-PVGKGYRSLNLALRKE--------------FDLYANVRPCKSLEG 414
+ ++ L G + + P + + L+ AL+K DL+ANVRPC S++
Sbjct: 63 IASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDD 122
Query: 415 IKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSI 522
+ + IREN+EG Y G ++ + + S+
Sbjct: 123 QSKPF---NFCIIRENSEGLYCGFDYFPLPKAIHSL 155
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 51.6 bits (118), Expect = 1e-05
Identities = 44/139 (31%), Positives = 67/139 (48%), Gaps = 16/139 (11%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVT------AVRGPDGKF----GIPQ 264
KV +I G GIGPE+ K+ + + + + T GK GI Q
Sbjct: 5 KVAVIAGDGIGPEVMDEGVKVLQTIANVSQQFKFEFTYFPWGCEFYSKHGKMMDDDGIEQ 64
Query: 265 -KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEG----IKTLY 429
KA D++ +G G P L L +R+ FD Y N+RP L+G +K +
Sbjct: 65 LKAFDAIYLGAVGFPG---VPDYISLWDLLLRIRQSFDQYVNIRPVTLLKGAPCPLKDVK 121
Query: 430 -DNVDVVTIRENTEGEYSG 483
+++D++ IREN+EGEY+G
Sbjct: 122 REDIDMLFIRENSEGEYAG 140
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 51.6 bits (118), Expect = 1e-05
Identities = 42/136 (30%), Positives = 64/136 (47%), Gaps = 14/136 (10%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGP--------DGKFGIPQKA 270
K+ +IPG GIG E+ K+ + V + +T + P G+ +P+ A
Sbjct: 5 KMAVIPGDGIGKEVMQEALKVVKC--VQERDSSLQITTMVFPWSSDYYLAHGRM-MPEDA 61
Query: 271 IDSV---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---D 432
++++ +A G G P L + +RK F Y N RP KSL GI + +
Sbjct: 62 LETLQKYDAILFGAIGDARVPDDVTVWELIMPIRKNFQQYVNFRPIKSLPGISSPLAGGN 121
Query: 433 NVDVVTIRENTEGEYS 480
++D V REN EGEYS
Sbjct: 122 DIDFVIFRENAEGEYS 137
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 51.6 bits (118), Expect = 1e-05
Identities = 42/133 (31%), Positives = 61/133 (45%), Gaps = 10/133 (7%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 282
K+ +IPG GIG E+ ++KI E + V +++E A +P A++
Sbjct: 3 KIAVIPGDGIGKEVVAEGLKVLRKIEELSNVKFDFQEYPFGAEHYLKTGETLPDWALEEF 62
Query: 283 ---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDV 444
+A G G G + L LR DLY N+RP K T + +D+
Sbjct: 63 RHFDAIYFGAIGDPRVKPGILEHGILLKLRFSLDLYVNLRPVKLYHPKLTPLKGKEKIDM 122
Query: 445 VTIRENTEGEYSG 483
V IRENTEG Y+G
Sbjct: 123 VFIRENTEGLYAG 135
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 51.6 bits (118), Expect = 1e-05
Identities = 38/137 (27%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 282
KV +I G GIGPE+ +K+ AA+ +EW ++ +A I + ++ +
Sbjct: 5 KVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETISESSLKEL 64
Query: 283 NANKIGLKGPL----MTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT-----LYDN 435
+ + G + G + + L +R +D Y N+RP K +EG++T +
Sbjct: 65 SKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKTAAD 124
Query: 436 VDVVTIRENTEGEYSGI 486
+D +RENTE Y GI
Sbjct: 125 IDFYVVRENTEDFYVGI 141
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 50.8 bits (116), Expect = 2e-05
Identities = 42/141 (29%), Positives = 62/141 (43%), Gaps = 17/141 (12%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVP---------IEWEEVDVTAVRG---PDGKFGI 258
++ IPG GIG E+ ++ EAA + EW D G PD +
Sbjct: 7 RIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDD-WAE 65
Query: 259 PQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN- 435
K D++ + + + + SL L R+EFD Y N+RP + G+ N
Sbjct: 66 QLKQYDAIYFGAVDWPDKVPDHISL-WGSL-LKFRREFDQYVNIRPVRLFPGVPCALANR 123
Query: 436 ----VDVVTIRENTEGEYSGI 486
+D V +RENTEGEYS +
Sbjct: 124 KVGDIDFVVVRENTEGEYSSL 144
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 50.8 bits (116), Expect = 2e-05
Identities = 45/150 (30%), Positives = 72/150 (48%), Gaps = 18/150 (12%)
Frame = +1
Query: 109 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRG----------PDGKFG 255
++K+ + G GIGPEI A ++F+A I ++ E++ A G PD
Sbjct: 1 MKKIVTLAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHPLPDDTLA 60
Query: 256 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL--- 426
K D++ IG PV + + L LA+RKE +L+AN+RP + + ++ L
Sbjct: 61 -AAKTADAILLAAIGSPQYDKAPV-RPEQGL-LAIRKELNLFANIRPVRIFDALRHLSPL 117
Query: 427 ----YDNVDVVTIRENTEGEYSGIEHEIVD 504
VD V +RE T G Y G +H + +
Sbjct: 118 KAERIAGVDFVVVRELTGGIYFG-QHTLTE 146
>UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Leuconostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 357
Score = 50.0 bits (114), Expect = 3e-05
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 20/164 (12%)
Frame = +1
Query: 103 TGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG--KFG--IPQKA 270
T V+K+ ++ G IGPEI A + +AA + + A G DG + G +PQ
Sbjct: 2 TSVKKIVVLKGDYIGPEIMTAGLAVLDAATKDTTFAYELIDAPFGGDGIDRAGDPLPQST 61
Query: 271 ID-SVNANKIGLK---GPLMTPVGKGYRSLNLALRKEFDLYANVRPCK------SLEGIK 420
ID S A+ + L GP + L +R + +L+AN+RP K +K
Sbjct: 62 IDVSKQADAVLLSAIGGPKWDNAPRRPEQGLLEIRSKLNLFANIRPTKVTAAQIDRSPLK 121
Query: 421 TLY-DNVDVVTIRENTEGEYSG----IE-HEIVDGVVQSIKLIT 534
Y +N D V +RE T G Y G +E H+ +D + S + +T
Sbjct: 122 PEYVENTDFVIVRELTSGAYFGKPRKLEAHQAIDTMYYSEEEVT 165
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 50.0 bits (114), Expect = 3e-05
Identities = 42/131 (32%), Positives = 57/131 (43%), Gaps = 11/131 (8%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAA---KVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNA 288
+ +IPG GIGPE+ + ++ AA V + + D A + ++ +
Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSEDAGADAFRRTGSAMSAATLERIRT 68
Query: 289 NKIG-LKGP-----LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--VDV 444
G LKGP + P G L LR D YANVRP L G+ VD
Sbjct: 69 RYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVDY 128
Query: 445 VTIRENTEGEY 477
V +RENTEG Y
Sbjct: 129 VIVRENTEGLY 139
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 49.6 bits (113), Expect = 5e-05
Identities = 42/144 (29%), Positives = 65/144 (45%), Gaps = 13/144 (9%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAA-----KVPIEWEEVDVTAVRGPDGKFGIPQKAIDS 279
++ IPG GIG E+ A ++ EA E+E + +P +D+
Sbjct: 5 RIATIPGDGIGKEVIPAGAQVLEALARTSKSFAFEFENFGWGGDYYREHGVMMPADGLDA 64
Query: 280 V---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-----KTLYDN 435
+ +A G G P L L + + FD YANVRP + L GI + +
Sbjct: 65 IRNKDAILFGSAGDPDIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDGPLKRCKPGD 124
Query: 436 VDVVTIRENTEGEYSGIEHEIVDG 507
++ V +REN+EGEYSG+ + G
Sbjct: 125 LNWVIVRENSEGEYSGVGGRVHQG 148
>UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_03000731;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000731 - Ferroplasma acidarmanus fer1
Length = 377
Score = 48.0 bits (109), Expect = 1e-04
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 12/129 (9%)
Frame = +1
Query: 127 IPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFG--IPQKAIDS 279
I G GIGPEIT A+ + +A IEW ++ + KFG +P+ +I
Sbjct: 29 IDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYE--KFGTYVPEDSIKE 86
Query: 280 VNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK---TLYDNVDVVT 450
+ I +K L K R LN LRK LY+N+R K +EG+ ++ +++
Sbjct: 87 IQKMYIAMKSTLNFMPDK--RDLNTILRKRLGLYSNIRILKYIEGMDIPVNTFNRLNLTI 144
Query: 451 IRENTEGEY 477
IR++T +
Sbjct: 145 IRDSTPNSH 153
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 48.0 bits (109), Expect = 1e-04
Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 12/136 (8%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 282
K+ ++PG G GPE+ K+ +AA E E + +P A + +
Sbjct: 6 KIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTTEKEYYNWGGAHYLATGETLPADAKEQL 65
Query: 283 NANKIGLKGPLMTP-VGKGYRSLNLALRKEFDL--YANVRPCKSLEGIKTLYDN-----V 438
+ L G + P V G + L+ FDL Y N+RP K G++T N +
Sbjct: 66 ARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKKPEDI 125
Query: 439 DVVTIRENTEGEYSGI 486
D V +REN+ G Y+G+
Sbjct: 126 DYVVVRENSGGVYTGM 141
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 48.0 bits (109), Expect = 1e-04
Identities = 27/73 (36%), Positives = 44/73 (60%)
Frame = +1
Query: 88 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQK 267
+A+Y G VT+IPG GIGPE+ + V+ +F A VP+++EEV V++ +
Sbjct: 21 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIC----N 75
Query: 268 AIDSVNANKIGLK 306
AI ++ N++ LK
Sbjct: 76 AIMAIRRNRVALK 88
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 48.0 bits (109), Expect = 1e-04
Identities = 40/142 (28%), Positives = 69/142 (48%), Gaps = 19/142 (13%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQ------ 264
++ ++ G GIGPE+ +K+ +A + + IE+ E DV + + +P+
Sbjct: 4 QIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGC 63
Query: 265 KAIDSVNANKIG-LKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK---SLEGIKTLYD 432
+A D++ +G K + P + R L LR F+L+ N+RP K LE + L
Sbjct: 64 EAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRS 123
Query: 433 NV-----DVVTIRENTEGEYSG 483
++ DV+ +RE T G Y G
Sbjct: 124 DISARGFDVLCVRELTGGIYFG 145
>UniRef50_Q08522 Cluster: Putative uncharacterized protein YOR135C;
n=1; Saccharomyces cerevisiae|Rep: Putative
uncharacterized protein YOR135C - Saccharomyces
cerevisiae (Baker's yeast)
Length = 113
Score = 46.8 bits (106), Expect = 3e-04
Identities = 25/43 (58%), Positives = 29/43 (67%), Gaps = 2/43 (4%)
Frame = -3
Query: 236 PLTAV--TSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVTL 114
PLT + TS SHS+GT AA KIF T ISGPIP P M+ T+
Sbjct: 5 PLTKIGLTSQDSHSMGTFAALKIFFTDLEISGPIPSPSMNETV 47
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 46.0 bits (104), Expect = 6e-04
Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 3/126 (2%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 297
V LIPG GIG EI V + I + D+++ R I ++ + +
Sbjct: 4 VALIPGDGIGREIMPGVAAAISSIS-DINFVTFDISSERYIKTGIIIKDDELEELKNYRA 62
Query: 298 GLKGPLMTP-VGKGY--RSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 468
L G + P V G + + L LR+E +LY N+RP +S + D + + +RENT+
Sbjct: 63 ILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD------DKIKITILRENTQ 116
Query: 469 GEYSGI 486
Y+ I
Sbjct: 117 DFYTDI 122
>UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Saccharomyces cerevisiae (Baker's yeast)
Length = 364
Score = 46.0 bits (104), Expect = 6e-04
Identities = 45/148 (30%), Positives = 63/148 (42%), Gaps = 20/148 (13%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEA-----AKVPIEWEE-------VDVTAVRGPDGKFG 255
+K+ ++PG +G EIT K+ +A + V ++E +D T V PD
Sbjct: 5 KKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALE 64
Query: 256 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK-------SLEG 414
+KA D+V +G GP L +RKE LYAN+RPC L
Sbjct: 65 ASKKA-DAVLLGAVG--GPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSP 121
Query: 415 IKTLY-DNVDVVTIRENTEGEYSGIEHE 495
IK + D V +RE G Y G E
Sbjct: 122 IKPQFAKGTDFVVVRELVGGIYFGKRKE 149
>UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 351
Score = 46.0 bits (104), Expect = 6e-04
Identities = 42/159 (26%), Positives = 66/159 (41%), Gaps = 17/159 (10%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 294
KV +PG GIGPE+T A ++ + EE + PQ+ D++
Sbjct: 3 KVVTLPGDGIGPEVTAAAAEVLREVAPDVHIEEHAIGGAAYEQFGDPFPQRTRDALGDAD 62
Query: 295 IGLKGPLMTPVGKGYRSLN---------LALRKEFDLYANVRPCKSLEGIK-------TL 426
L G + + SL LALR+ YAN+RP + L G++ L
Sbjct: 63 AVLLGTVGGAQNSPWNSLPRPLRPESGLLALRRALGCYANLRPVRVLPGLEHLSPLKPEL 122
Query: 427 YDNVDVVTIRENTEGEYSGIEHEIV-DGVVQSIKLITEE 540
VD++ +RE G Y + +I D +++ T E
Sbjct: 123 ARGVDILIVRELLGGIYFDGDRKIEGDTAYNTMRYTTPE 161
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 45.6 bits (103), Expect = 7e-04
Identities = 37/132 (28%), Positives = 58/132 (43%), Gaps = 11/132 (8%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQ------KAI 273
+ ++ G GIGPE+ A + +A VD A K G P +
Sbjct: 7 IAVVHGDGIGPEVARAAVAVLQAGVQAGTLRFVDYPAGADHFLKTGDSFPAASFEGCRTA 66
Query: 274 DSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDV 444
D++ G+ G + + L LR + DL+ANVRP K +G+ + +D
Sbjct: 67 DAILHGAAGIPGVVHPDGTEAGLDFTLTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDY 126
Query: 445 VTIRENTEGEYS 480
V +REN+EG Y+
Sbjct: 127 VIVRENSEGLYA 138
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 45.6 bits (103), Expect = 7e-04
Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 25/153 (16%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAK-----VPIEWEEVDVTAV-------RGPDGKFGIP 261
V +IPG GIG E A +++ +AA + E+ E + P G F
Sbjct: 6 VAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKG-FLNT 64
Query: 262 QKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---- 429
D++ +G G P L L +R+ F+ Y N+RP + L G+ +
Sbjct: 65 LANFDTILLGAVGYPG---VPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRN 121
Query: 430 -DNVDVVTIRENTEGEYS--------GIEHEIV 501
+V+ V IRENTEGEYS G+ HE+V
Sbjct: 122 PGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVV 154
>UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Hypocreales|Rep: 3-isopropylmalate dehydrogenase -
Cephalosporium acremonium (Acremonium chrysogenum)
Length = 380
Score = 45.2 bits (102), Expect = 0.001
Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 17/151 (11%)
Frame = +1
Query: 103 TGVRKVTLIPGHGIGPEITVAVQKIFEAAKV--PIEWEEVDVTAVRGPD-GKFGIP--QK 267
T K+ ++PG IGPEI K+ + P + V G G+P Q
Sbjct: 2 TTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQS 61
Query: 268 AIDSVNANKIGLKGPLMTPVGKGYR----SLNLALRKEFDLYANVRPCK----SLEGIKT 423
+D+ A+ L G + P G S L LR+ D +AN+RPC+ SL G
Sbjct: 62 VLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASP 121
Query: 424 LYDNV----DVVTIRENTEGEYSGIEHEIVD 504
+ ++V + +REN G Y G + E D
Sbjct: 122 IREHVVKGTRFIVVRENCGGAYFGEKKEEED 152
>UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Streptococcus suis 89/1591|Rep:
Isocitrate/isopropylmalate dehydrogenase - Streptococcus
suis 89/1591
Length = 207
Score = 44.8 bits (101), Expect = 0.001
Identities = 40/139 (28%), Positives = 61/139 (43%), Gaps = 15/139 (10%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRGPD---GKFGIPQKAIDS 279
+K+ + G GIGPEI A ++ EA + ++ E++ A G +P + +
Sbjct: 3 KKIVALAGDGIGPEIMEAGLEVLEAVAGQVGFDYEIEERAFGGAGIDAAGHPLPNATLQA 62
Query: 280 VN-ANKI---GLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL------- 426
A+ I + P L LRKE L+AN+RP K + +K
Sbjct: 63 CRQADAILLAAIGSPQYDDAAVRPEQGLLQLRKELGLFANIRPVKIFDSLKDYSPLKADR 122
Query: 427 YDNVDVVTIRENTEGEYSG 483
D VD+V +RE T G Y G
Sbjct: 123 LDGVDLVMVRELTGGIYFG 141
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 44.0 bits (99), Expect = 0.002
Identities = 32/146 (21%), Positives = 69/146 (47%), Gaps = 1/146 (0%)
Frame = +1
Query: 106 GVRKVTLIPGHGI-GPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 282
G+ V+L+ G I G + V + +++VP+E + ++ G D ++ SV
Sbjct: 61 GINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEA----GQDDEY------FHSV 110
Query: 283 NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIREN 462
N+ + ++L + + DLY +S G K + VD+ I +N
Sbjct: 111 LRNRTAVHVDNQADAEAKQKALKIC--NDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQN 168
Query: 463 TEGEYSGIEHEIVDGVVQSIKLITEE 540
G ++ +E+ V+GVV+++ +++++
Sbjct: 169 NMGIFNELEYSPVEGVVEALSVVSQK 194
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 43.6 bits (98), Expect = 0.003
Identities = 50/163 (30%), Positives = 75/163 (46%), Gaps = 21/163 (12%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAA-----KVPIEWEEVDVTA----VRGPDGKFGIPQK 267
K+ LI G GIG ++ A + E A + ++E+ A G D + G ++
Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEER 61
Query: 268 A--IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-KTLYD-- 432
A D++ IGL P + S +L LR F LYA VRP K+ + L D
Sbjct: 62 AGLADAIFLGAIGL--PSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPR 119
Query: 433 --NVDVVTIRENTEG-EYSGIEHE----IVDGVVQSIKLITEE 540
+D+V +RE+TEG YS H+ + D VQ + IT +
Sbjct: 120 AAGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRK 162
>UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Acidobacteria bacterium Ellin345|Rep: 3-isopropylmalate
dehydrogenase - Acidobacteria bacterium (strain
Ellin345)
Length = 403
Score = 43.2 bits (97), Expect = 0.004
Identities = 40/150 (26%), Positives = 64/150 (42%), Gaps = 26/150 (17%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 297
V +PG GIG ++ ++ EA + D+ + +P + I + +K+
Sbjct: 6 VVTMPGDGIGNQVLPQAIRVLEAVGFEANYVHADIGWECWCNEGNALPDRTIQLLRKHKL 65
Query: 298 GLKGPLMTPV-------------GKG--YRSLNLALRKEFDLYANVRPCKSLEGIKTLY- 429
GL G + + GKG Y S + +R+ F+L +RPC S G +
Sbjct: 66 GLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPGNPLNFI 125
Query: 430 ----------DNVDVVTIRENTEGEYSGIE 489
VDVV R+NTEG Y+G+E
Sbjct: 126 RQTTCGGFEEPQVDVVVFRQNTEGLYAGVE 155
>UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;
Bacteria|Rep: 3-isopropylmalate dehydrogenase - Brucella
melitensis
Length = 370
Score = 43.2 bits (97), Expect = 0.004
Identities = 46/150 (30%), Positives = 65/150 (43%), Gaps = 19/150 (12%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIF----EAAKVPIEWEEVDVTA----VRGPDGKFGIPQK 267
RK+ L+PG GIGPE V+K+ + E EE V G +K
Sbjct: 4 RKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAISDADMEK 63
Query: 268 AI--DSVNANKIGLKGPLMTPVGKGYRSLN--LALRKEFDLYANVRPCKSLEGI------ 417
A+ D+V +G GP V R L LRK+ LYAN+RP +
Sbjct: 64 ALAADAVLFGAVG--GPKWDSVPYEVRPEGGLLRLRKDMQLYANLRPAICYPALAHSSSL 121
Query: 418 -KTLYDNVDVVTIRENTEGEYSGIEHEIVD 504
+ + +D++ +RE T G Y G EI+D
Sbjct: 122 KPEVIEGLDILILRELTGGVYFGEPKEIID 151
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 42.7 bits (96), Expect = 0.005
Identities = 38/153 (24%), Positives = 69/153 (45%), Gaps = 13/153 (8%)
Frame = +1
Query: 82 AGAAQYSTGVRKVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGK 249
AG + + ++ G GIGPE+ ++KI + + + + E A
Sbjct: 6 AGTPMSANNAFHIAVLAGDGIGPEVMAPAIEVLRKIEQKSDLRFRFTEAPAGANNYLATG 65
Query: 250 FGIPQKAI---DSVNANKIGLKG-PLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI 417
+P++ I + +A +G G P + + + LR FDLYA VRP + + G+
Sbjct: 66 KSMPERTIKLCEEADAILLGACGLPSVRYPDNTEIAPQIELRFIFDLYAGVRPARLIPGV 125
Query: 418 KTLY-----DNVDVVTIRENTEGEYSGIEHEIV 501
+ +D+V IRE+TEG ++ + +V
Sbjct: 126 PSPIVGADTRGIDLVVIRESTEGLFASMGKGVV 158
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 42.7 bits (96), Expect = 0.005
Identities = 42/153 (27%), Positives = 63/153 (41%), Gaps = 18/153 (11%)
Frame = +1
Query: 79 RAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAA-----------KVPIEWEEVDVT 225
RA A + +VT++PG GIGPEIT + EAA + I D T
Sbjct: 28 RARPALATCAAHRVTVLPGDGIGPEITAVTLSVLEAAGKAEGESFTFTEALIGGAAYDAT 87
Query: 226 AVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKS 405
PD + + + A G K + V K L L LR + +AN+RP
Sbjct: 88 GDPYPDATYRACADSDAVLLAAIGGYKWDALPSVSKPETGL-LRLRSSLNAFANLRPATV 146
Query: 406 LEGI-------KTLYDNVDVVTIRENTEGEYSG 483
+ + + + + VD++ +RE G Y G
Sbjct: 147 IPELADASSLKREVLEGVDLLIVRELVGGIYFG 179
>UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1;
Candida albicans|Rep: Putative uncharacterized protein -
Candida albicans (Yeast)
Length = 150
Score = 42.3 bits (95), Expect = 0.007
Identities = 45/124 (36%), Positives = 55/124 (44%), Gaps = 7/124 (5%)
Frame = -3
Query: 476 YSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLAYKSNSFLRAKLSDL*P--LPTGVIRGPF 303
Y SVFS +T ST + IPS L G TLAYK N FL A + + P L G P
Sbjct: 2 YKSSVFSRTITIST---GLPIPSTDLTGSTLAYKPNFFLNATIGEEYPATLVVGDETAPN 58
Query: 302 K-PILLAFTESIAFWG--IPNLPSGPLTAVTSTSSHSIGTLAA--SKIF*TATVISGPIP 138
P F S G +P + A T+S+ LA SK A + S PIP
Sbjct: 59 NAPSHSFFKTSTVSSGKAVPVFLNNSKPASKLTNSNCKSCLAGKFSKTALPAGITSRPIP 118
Query: 137 CPGM 126
PG+
Sbjct: 119 SPGI 122
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 41.5 bits (93), Expect = 0.012
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 12/133 (9%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAK------VPIEWEEVDVTAVR--GPDGKFGIPQKA 270
++ ++P GIGPEI A ++ +A + ++++V T++ G + + KA
Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAKA 61
Query: 271 IDSVNANKIGLKGPLMTPV-GKGYRSLNLALRKEFDLYANVRPCKS---LEGIKTLYDNV 438
+ + +G + P KG R+++ R DLYANVRP ++ L +
Sbjct: 62 -KTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTM 120
Query: 439 DVVTIRENTEGEY 477
D+V +RE TEG Y
Sbjct: 121 DLVIMREATEGFY 133
>UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Bacteroides thetaiotaomicron
Length = 353
Score = 41.5 bits (93), Expect = 0.012
Identities = 40/146 (27%), Positives = 68/146 (46%), Gaps = 19/146 (13%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAA------KVPIEW-----EEVDVTAVRGPDGKFGIP 261
K+ ++ G GIGPEI+V + A KV E+ + +D P+ + +
Sbjct: 4 KIAVLAGDGIGPEISVQGVDVMSAVCEKFGHKVSYEYAICGADAIDKVGDPFPEETYEVC 63
Query: 262 QKAIDSVNANKIGLKGPLMTPVGKGYRSLNL-ALRKEFDLYANVRPCKSLEGI------- 417
+ A D+V + +G P K L A+RK+ L+AN+RP ++ + +
Sbjct: 64 KNA-DAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLIHKSPLR 122
Query: 418 KTLYDNVDVVTIRENTEGEYSGIEHE 495
L +N D + IRE T G Y G +++
Sbjct: 123 AELVENADFICIRELTGGMYFGEKYQ 148
>UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Candida maltosa (Yeast)
Length = 251
Score = 40.7 bits (91), Expect = 0.021
Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 19/151 (12%)
Frame = +1
Query: 100 STGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGI------- 258
S + +T++PG +G EI K+ EA + ++++ G I
Sbjct: 2 SVKTKTITILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVPL 61
Query: 259 PQKAIDSVNANKIGLKGPLMTPV-GKGYRSLN---LALRKEFDLYANVRPCK----SLEG 414
P A++S + L G + P G G L +RKE +LYAN+RPC SL
Sbjct: 62 PDDALESAKNSDAVLLGAVGGPKWGTGALRPEQGLLKIRKELNLYANIRPCNFASDSLLE 121
Query: 415 IKTLYDNV----DVVTIRENTEGEYSGIEHE 495
+ L V +++ +RE G Y G E
Sbjct: 122 LSPLRPEVVKGTNLIIVRELVGGIYFGDREE 152
>UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Dikarya|Rep: 3-isopropylmalate dehydrogenase -
Phanerochaete chrysosporium (White-rot fungus)
(Sporotrichumpruinosum)
Length = 380
Score = 40.3 bits (90), Expect = 0.028
Identities = 43/147 (29%), Positives = 59/147 (40%), Gaps = 19/147 (12%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA--VRGPD-GKFGIPQKAIDSVN 285
K+ ++PG GIGPE+ ++ E E+ + G K G P A ++
Sbjct: 7 KIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCSIDKHGEPLTAA-TLE 65
Query: 286 ANKIG---LKGPLMTP---VGKGYRSLN--LALRKEFDLYANVRPCKSLEGIKTLYD--- 432
A K+ L G + P V R LALRK LYAN+RP Y
Sbjct: 66 ACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYSPLK 125
Query: 433 -----NVDVVTIRENTEGEYSGIEHEI 498
VD++ IRE G Y G E+
Sbjct: 126 PSVARGVDIIVIRELIGGAYFGERKEL 152
>UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Nostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Nodularia spumigena CCY 9414
Length = 422
Score = 39.9 bits (89), Expect = 0.037
Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 15/138 (10%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVA-VQKIFEAAK-----VPIEWEEVDVTAVRGPDGKFG--IPQKA 270
++ IPG GIGPE+ A +Q + + AK + +++ + TA+ KFG PQ
Sbjct: 69 RIVAIPGEGIGPEVVAASLQLLQQVAKLEGFTLQVDYGWLGTTALE----KFGTYFPQAT 124
Query: 271 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-------KTLY 429
+ N G G + V +G L LRK +D + N+RP + ++ +
Sbjct: 125 AELCN----GSDGIVFGAVTQGGL---LELRKHYDFFCNLRPIRIVDSLVNKSSLRPEKI 177
Query: 430 DNVDVVTIRENTEGEYSG 483
+D++ IRE G Y G
Sbjct: 178 KGLDILVIRELVSGIYFG 195
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 39.1 bits (87), Expect = 0.065
Identities = 40/140 (28%), Positives = 62/140 (44%), Gaps = 18/140 (12%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIF----EAAKVPIEWEEVDVTAVRG-PDGKFGIPQKAIDSV 282
V ++ G GIGPE+T +I + P+ E + GK +P ++++
Sbjct: 10 VAVVGGEGIGPEVTDQSHRILKWFSDRRGAPVILREAQYGLIPYLATGKV-LPDDTVEAM 68
Query: 283 N-ANKI---GLKGPLMTPVGKGYRSLN--LALRKEFDLYANVRPCKSLEGI-------KT 423
A+ I GP T V R L+LR ++DLYAN+RP + +
Sbjct: 69 EEADAILWGATGGPETTEVPPAARKAGSLLSLRSKYDLYANLRPIVANPALADSAPLKAA 128
Query: 424 LYDNVDVVTIRENTEGEYSG 483
+ +VD + IRE T G Y G
Sbjct: 129 VLKDVDFIIIRELTSGIYFG 148
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 39.1 bits (87), Expect = 0.065
Identities = 19/47 (40%), Positives = 31/47 (65%)
Frame = +1
Query: 88 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA 228
+A+Y G+ VT+ PG G GPE+ + V +A VP+++EEV V++
Sbjct: 9 SAKYG-GILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSS 54
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 38.7 bits (86), Expect = 0.086
Identities = 39/139 (28%), Positives = 60/139 (43%), Gaps = 17/139 (12%)
Frame = +1
Query: 118 VTLIPGHGIGPEIT----VAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV- 282
+ L+PG GIGPEI + + K+ E ++ + + + +PQ ID+
Sbjct: 5 IVLLPGDGIGPEIVEQARLVLVKVAERFGHTFDFSSHQIGGIAIDETGDPLPQPTIDACR 64
Query: 283 NANKI---GLKGPLM-TPVGKGYRSLN-LALRKEFDLYANVRPCKSLEGI-------KTL 426
NA I + GP P K L +RKE L+AN+RP K + + +
Sbjct: 65 NAAAILLGAVGGPKWDDPSAKTRPEAGLLKIRKELGLFANLRPIKLFDELADASPLRADI 124
Query: 427 YDNVDVVTIRENTEGEYSG 483
D++ RE T G Y G
Sbjct: 125 VKGTDILFFRELTGGIYFG 143
>UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 363
Score = 38.3 bits (85), Expect = 0.11
Identities = 40/145 (27%), Positives = 62/145 (42%), Gaps = 18/145 (12%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 282
KV ++ G IGPE+ V +F+ + + +E E + I + +
Sbjct: 14 KVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGSCLDQHDCPIQESTLQEA 73
Query: 283 NANKIGLKGPLMTP---VGKGYRSLN---LALRKEFDLYANVRPCK-------SLEGIKT 423
+ L G + P VG R L +RK +LYANVRP K L +K
Sbjct: 74 SECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLELSSLKE 133
Query: 424 -LYDNVDVVTIRENTEGEYSGIEHE 495
+ V+++T+REN G Y G + E
Sbjct: 134 HVVRGVNIITLRENAGGIYFGRKQE 158
>UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Helicobacter hepaticus
Length = 357
Score = 38.3 bits (85), Expect = 0.11
Identities = 40/147 (27%), Positives = 62/147 (42%), Gaps = 18/147 (12%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIE----WEEVDVTAVRGPDGKFGIPQKAIDS 279
+++ +I G GIG E+ KI +A E +EEV + +P K++
Sbjct: 3 KRIAVIYGDGIGKEVITQALKILKAVAKKYEHTFIFEEVLAGGAAIDECGECLPMKSLQI 62
Query: 280 VNANKIGLKGPLMTPVGKGYRSLN------LALRKEFDLYANVRPCKSLEGI-------- 417
+ L G + P S N L LRKE L+AN+RP L +
Sbjct: 63 CKQSDSVLLGAVGGPKWDNEPSHNRPEKALLTLRKELGLFANIRPATLLPQLSKASPLKD 122
Query: 418 KTLYDNVDVVTIRENTEGEYSGIEHEI 498
+ L +D + +RE G Y G EH++
Sbjct: 123 EILNRGIDFIIVRELIGGVYFG-EHKL 148
>UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Gammaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 389
Score = 37.9 bits (84), Expect = 0.15
Identities = 43/140 (30%), Positives = 58/140 (41%), Gaps = 19/140 (13%)
Frame = +1
Query: 115 KVTLIPGHGIGPEITVAVQKIFEAAKVP------IEWEEVDVTAVRGP--DGKFGIPQKA 270
+V ++PG GIGPE+ A + EA P + W G +
Sbjct: 9 QVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPADWRGQLAG 68
Query: 271 IDSVNANKIGLKGP------LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT-LY 429
D++ +G GP P G L L LRK DL+A RP L G L
Sbjct: 69 YDALLLGALGDPGPSHDAQRYCLPDGVSLAPL-LQLRKGLDLWACERPAVPLAGAPMPLS 127
Query: 430 D----NVDVVTIRENTEGEY 477
D + D++ IREN+EGEY
Sbjct: 128 DPRALHTDLLVIRENSEGEY 147
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 37.5 bits (83), Expect = 0.20
Identities = 45/155 (29%), Positives = 69/155 (44%), Gaps = 20/155 (12%)
Frame = +1
Query: 79 RAGAAQYSTGVRKVTLIPGHGIGPE-ITVA---VQKI-------FEAAKVPIEWEEVDVT 225
R AA + L+PG GIGPE I+VA +QK F+ ++P+ +D+
Sbjct: 36 RCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLV 95
Query: 226 AVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYR--SLNLALRKEFDLYANVRPC 399
V P+ F K D++ IG G K R LR++ ++AN+RP
Sbjct: 96 GVPLPEETF-TAAKLSDAILLGAIG--GYKWDKNEKHLRPEMALFYLRRDLKVFANLRPA 152
Query: 400 KSLEGI-------KTLYDNVDVVTIRENTEGEYSG 483
L + K + + VD++ +RE T G Y G
Sbjct: 153 TVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFG 187
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 37.1 bits (82), Expect = 0.26
Identities = 34/136 (25%), Positives = 58/136 (42%), Gaps = 14/136 (10%)
Frame = +1
Query: 118 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF-----GIPQKAIDSV 282
+ ++ G GIGPE+ ++ E + ++ E + G++ +PQ A D+
Sbjct: 7 LVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQSAYDAC 66
Query: 283 NANKIGLKGPLMTPVGKGYRSLNLA----LRKEFDLYANVRPCKSLEGIKTLYDN----- 435
A+ L G + P + +A LR+ LY VRP + T
Sbjct: 67 LASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGE 126
Query: 436 VDVVTIRENTEGEYSG 483
+D V +RE+TEG + G
Sbjct: 127 IDFVLVRESTEGLFYG 142
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 36.7 bits (81), Expect = 0.35
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 12/82 (14%)
Frame = +1
Query: 298 GLKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGI--------KTLYD--NVD 441
G GP++ K G+ + + R +LYANVRP K G+ K +++ VD
Sbjct: 65 GTGGPVLMKDNKMAGFSPV-IGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVD 123
Query: 442 VVTIRENTEGEYSGIEHEIVDG 507
+V IRENTEG Y+ ++ G
Sbjct: 124 MVIIRENTEGLYAPTGGKLAPG 145
>UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Candidatus Carsonella ruddii PV|Rep: 3-isopropylmalate
dehydrogenase - Carsonella ruddii (strain PV)
Length = 349
Score = 36.3 bits (80), Expect = 0.46
Identities = 38/129 (29%), Positives = 57/129 (44%), Gaps = 9/129 (6%)
Frame = +1
Query: 124 LIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPD-GKFGIPQ--------KAID 276
++PG GIGPEI V KI ++ + + G KF P K ID
Sbjct: 6 ILPGDGIGPEIIKQVIKIVKSCIYTGYKINIIYNYIGGISIDKFNTPITNNLISIIKYID 65
Query: 277 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 456
++ +G + K L L LRK+F+ + N+RP IK + N+D++ +R
Sbjct: 66 TIFLGCVG-GYKWNHSIFKPEYGL-LKLRKKFNFFTNIRP------IKCPFKNIDIIIVR 117
Query: 457 ENTEGEYSG 483
E G Y G
Sbjct: 118 ELNGGIYYG 126
>UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 1175
Score = 36.3 bits (80), Expect = 0.46
Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
Frame = +1
Query: 289 NKIGLKGPLMTPVGKGYRSLNLALRKEFDL---YANVRPCKSLEGIKTLYDNVDVVTIRE 459
NK+ L G + V KG+ + L++ K+ + Y +V + L + T N+ +++ +
Sbjct: 533 NKLNLNGSALIAVVKGFLNGELSMWKKISMDTNYMHVSDLQLLTALFTRMPNLRELSLSD 592
Query: 460 NTEGEYSGIEHEIVD 504
N + +GIE+E+ D
Sbjct: 593 NFDASMAGIEYELPD 607
>UniRef50_Q6JAD6 Cluster: Putative uncharacterized protein; n=1; Zea
mays|Rep: Putative uncharacterized protein - Zea mays
(Maize)
Length = 725
Score = 35.1 bits (77), Expect = 1.1
Identities = 18/62 (29%), Positives = 32/62 (51%)
Frame = -3
Query: 317 IRGPFKPILLAFTESIAFWGIPNLPSGPLTAVTSTSSHSIGTLAASKIF*TATVISGPIP 138
+ P +P+ LAFT + P P P +AV ST++ ++ A++ + A +S +P
Sbjct: 627 VTSPLRPVTLAFTSPVLSSVCPQPPVPPASAV-STTAVAVSVTASAPVAPAALPVSESVP 685
Query: 137 CP 132
P
Sbjct: 686 AP 687
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 34.7 bits (76), Expect = 1.4
Identities = 43/149 (28%), Positives = 70/149 (46%), Gaps = 21/149 (14%)
Frame = +1
Query: 100 STGVR--KVTLIPGHGIGPEITVAVQKIFE--AAKV--PIEWEE-------VDVTAVRGP 240
S+ VR ++T + G GIGPEI + + + AA+V ++W+E + T P
Sbjct: 5 SSAVRTYRITALAGDGIGPEIMQVGRAVLDAVAAQVGFSLQWQEGLIGGAAYEATGDPLP 64
Query: 241 DGKFGIPQKAIDSVNANKIG-LKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK----- 402
+ Q++ D+V +G K + + R+L L LR L+AN+RP K
Sbjct: 65 PETLKMAQES-DAVYLAAVGDFKYDTLPREKRPERAL-LGLRAGLGLFANLRPVKIFPQL 122
Query: 403 -SLEGIK-TLYDNVDVVTIRENTEGEYSG 483
+K + +D+V +RE T G Y G
Sbjct: 123 VQASSLKPEVVAGIDLVVVRELTGGIYFG 151
>UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 382
Score = 34.7 bits (76), Expect = 1.4
Identities = 35/147 (23%), Positives = 61/147 (41%), Gaps = 19/147 (12%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGI-------PQKA 270
+ +T++PG +G E+ K+ +A + + + + G I P ++
Sbjct: 15 KTITVLPGDHVGEEVCNEAIKVLQAIEDATPYRNIKFNLQKHLIGGAAIDATGTPLPDES 74
Query: 271 IDSVNANKIGLKGPLMTPV-GKGYRSLN---LALRKEFDLYANVRPCK-------SLEGI 417
+++ + L G + P G G L +RKE +LYAN+RPC L +
Sbjct: 75 LEAAKNSDAVLLGAVGGPKWGTGSVRPEQGLLKIRKELNLYANLRPCNFASDSLLELSPL 134
Query: 418 KT-LYDNVDVVTIRENTEGEYSGIEHE 495
K+ + D +RE G Y G E
Sbjct: 135 KSEIVKGTDFTVVRELVGGIYFGERQE 161
>UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep:
Phage integrase - Clostridium thermocellum (strain ATCC
27405 / DSM 1237)
Length = 330
Score = 34.3 bits (75), Expect = 1.8
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Frame = +1
Query: 280 VNANKIGLKGPLMTPVGKGYRS----LNLALRKEFDLYANVRPCKSLEGIKTLY 429
VN N +K ++T VGKG + LN A +K D Y VRP ++ L+
Sbjct: 177 VNINLSNIKNDVLTVVGKGNKERTIYLNAACKKALDAYLKVRPVDGVKDKNALF 230
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 34.3 bits (75), Expect = 1.8
Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 15/148 (10%)
Frame = +1
Query: 112 RKVTLIPGHGIGPEITVAVQKIFEAAK------VPIEWEEVDVTAVRGPDGKFGIPQKAI 273
+++ + G G+GPE+ + +++ + ++ E A+ G+ +PQ+ +
Sbjct: 3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAI-DLTGQ-PLPQRTL 60
Query: 274 DSVNANKIGLKGPLMTPVGKGYRSLN----LALRKEFDLYANVRPCKSLEGIKTL----- 426
+ A+ L G + P G + LALRK ++ANVRP L
Sbjct: 61 AACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK 120
Query: 427 YDNVDVVTIRENTEGEYSGIEHEIVDGV 510
D +D V +RE T G Y E D V
Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKERTDEV 148
>UniRef50_Q7RB56 Cluster: Fulmal1; n=2; Plasmodium (Vinckeia)|Rep:
Fulmal1 - Plasmodium yoelii yoelii
Length = 835
Score = 33.9 bits (74), Expect = 2.4
Identities = 11/22 (50%), Positives = 16/22 (72%)
Frame = +3
Query: 24 CENS*NGCKNNQENCASDQSRR 89
C+N NGCKN + NC +DQ+ +
Sbjct: 213 CKNGENGCKNGEHNCKNDQNSK 234
>UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2;
Bradyrhizobiaceae|Rep: Glycosidase, PH1107-related -
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Length = 373
Score = 33.5 bits (73), Expect = 3.2
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Frame = +1
Query: 196 PIEWEEV-DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK--GYRSLNLALRK 366
P+E E V + A RGPDG+ + + + N ++IG+ L +G G L +AL
Sbjct: 20 PLEAEGVLNPAAARGPDGQLYLFPRLVARGNHSRIGIARVLFNEIGDPVGVERLGIALEP 79
Query: 367 EFD 375
E D
Sbjct: 80 EMD 82
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 33.5 bits (73), Expect = 3.2
Identities = 15/31 (48%), Positives = 22/31 (70%)
Frame = +1
Query: 88 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIF 180
+A+Y G VT+IPG GIGPE+ + V+ +F
Sbjct: 106 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVF 135
>UniRef50_UPI0000D5678D Cluster: PREDICTED: similar to CG33087-PC;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG33087-PC - Tribolium castaneum
Length = 1872
Score = 32.7 bits (71), Expect = 5.6
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +3
Query: 3 LPLVFAICENS*NGCKNNQENCASDQSRRCSIQHWR-AQGYAHPWTW 140
+P V+ +C+ N C +N + QSR CS QH+R + G P +W
Sbjct: 776 IPAVW-VCDTD-NDCGDNSDEQQDCQSRTCSPQHYRCSSGRCIPMSW 820
>UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Psychromonas ingrahamii 37|Rep: 3-isopropylmalate
dehydrogenase - Psychromonas ingrahamii (strain 37)
Length = 368
Score = 32.7 bits (71), Expect = 5.6
Identities = 39/144 (27%), Positives = 61/144 (42%), Gaps = 22/144 (15%)
Frame = +1
Query: 118 VTLIPGHGIGPEI---TVAVQKIFEAAKVPIEWEEVDV----TAVRGPDGKFGIPQKA-- 270
+ L+ G GIGPE+ V V K+ E + +E DV A F KA
Sbjct: 6 IALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAMGHAFPDETKAAC 65
Query: 271 --IDSVNANKIGL--KGPLMTPVG-KGYRSLNLALRKEFDLYANVRPCKSLEGI------ 417
D++ IGL + P+ + R L LR+ ++ +AN RP +G+
Sbjct: 66 DKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHFSPL 125
Query: 418 --KTLYDNVDVVTIRENTEGEYSG 483
+ + +D++ IRE G Y G
Sbjct: 126 KASVIGEGIDIMIIRELVGGLYFG 149
>UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10 -
Vibrio marinus (Moritella marina)
Length = 2011
Score = 32.3 bits (70), Expect = 7.4
Identities = 13/39 (33%), Positives = 22/39 (56%)
Frame = +1
Query: 424 LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEE 540
+YD D+V E G+ G E+ I+DG + ++L T +
Sbjct: 1156 IYDQADLVEFAEGDIGKVFGAEYNIIDGYSRRVRLPTSD 1194
>UniRef50_Q1ASC3 Cluster: Phosphomethylpyrimidine kinase type-2;
n=1; Rubrobacter xylanophilus DSM 9941|Rep:
Phosphomethylpyrimidine kinase type-2 - Rubrobacter
xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 264
Score = 32.3 bits (70), Expect = 7.4
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Frame = +1
Query: 91 AQYSTGVRKVTLIPGHGIGPEITVAVQKI-FEAAKVPIEWEEVDVTAVRGPDGKFGIPQK 267
AQ + GVR + P +I V+ I +AAK + + ++AV G + GIP
Sbjct: 41 AQNTVGVRSIFPFPPRVAVDQIEAVVEDIGADAAKTGMLFNAEIISAVAGAVRRLGIPNL 100
Query: 268 AIDSVNANKIGLK 306
+D V + G K
Sbjct: 101 VVDPVMVAESGAK 113
>UniRef50_A5DW24 Cluster: Putative uncharacterized protein; n=2;
Saccharomycetales|Rep: Putative uncharacterized protein -
Lodderomyces elongisporus (Yeast) (Saccharomyces
elongisporus)
Length = 1274
Score = 32.3 bits (70), Expect = 7.4
Identities = 18/60 (30%), Positives = 35/60 (58%), Gaps = 1/60 (1%)
Frame = -2
Query: 402 LARSDISVQVKLLPEGQVE*SVA-FTDWSHQGTLQANFIGIYRVNRFLGDTEFAIWTPNS 226
+ R ++ VQ+KLL + + E S+A +T+W + Q ++I +++F G+ WT +S
Sbjct: 1189 IKRHELLVQLKLLNKMEKEISMAEYTNWLYAEVQQCDYIQESILSQFSGNNPRGDWTESS 1248
>UniRef50_Q4RK60 Cluster: Chromosome 2 SCAF15032, whole genome shotgun
sequence; n=7; Eumetazoa|Rep: Chromosome 2 SCAF15032,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 4421
Score = 31.9 bits (69), Expect = 9.8
Identities = 14/45 (31%), Positives = 23/45 (51%)
Frame = +1
Query: 202 EWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKG 336
E+ ++ + + G +GK G+ D N + G GP+ TP KG
Sbjct: 3543 EYGDIGLDGINGEEGKGGVSGPPGDRGNPGRRGAPGPIGTPGNKG 3587
>UniRef50_Q2S2N6 Cluster: Possible
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; n=1;
Salinibacter ruber DSM 13855|Rep: Possible
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase -
Salinibacter ruber (strain DSM 13855)
Length = 220
Score = 31.9 bits (69), Expect = 9.8
Identities = 28/98 (28%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Frame = +1
Query: 211 EVDVTAVRGPDGKFGIPQK-AIDSVNANKIGLKGPLMTPVGKG-YRSLNLALRKEFDLYA 384
EV++ AV G +GK IP+ A+D V +GL + R ++ K FD +A
Sbjct: 68 EVELVAVVGTEGK-NIPRSAALDHVAGYAVGLDMTARDLQAEAKERRHPWSVAKGFDTFA 126
Query: 385 NVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEI 498
+ P + E + + D +T+ + T E S H+I
Sbjct: 127 PLGPIQPAEAVDDVQDLTLRLTVNDETRQEAS-TRHQI 163
>UniRef50_A7CVJ0 Cluster: Putative uncharacterized protein
precursor; n=1; Opitutaceae bacterium TAV2|Rep: Putative
uncharacterized protein precursor - Opitutaceae
bacterium TAV2
Length = 938
Score = 31.9 bits (69), Expect = 9.8
Identities = 14/39 (35%), Positives = 23/39 (58%)
Frame = +1
Query: 130 PGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG 246
PG G+ PE +V +Q++ E + PI W+ + T+ R G
Sbjct: 50 PG-GVSPEFSVLLQRLPEPTRWPILWQSMAETSARAETG 87
>UniRef50_A6DQ62 Cluster: Phosphomannomutase; n=1; Lentisphaera
araneosa HTCC2155|Rep: Phosphomannomutase - Lentisphaera
araneosa HTCC2155
Length = 464
Score = 31.9 bits (69), Expect = 9.8
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Frame = +1
Query: 133 GHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF--GIPQKAIDSVNA 288
G+G I A++K F+ VP+E+ +++ PDGKF GIP + S A
Sbjct: 182 GNGAAGHIIDAIEKEFQNKNVPVEFIKIN----NEPDGKFPKGIPNPLLHSCRA 231
>UniRef50_P83723 Cluster: Unknown protein NF004 from 2D-PAGE; n=7;
cellular organisms|Rep: Unknown protein NF004 from
2D-PAGE - Naegleria fowleri
Length = 24
Score = 31.9 bits (69), Expect = 9.8
Identities = 14/19 (73%), Positives = 14/19 (73%)
Frame = +1
Query: 121 TLIPGHGIGPEITVAVQKI 177
TL PGHGIGPEI AV I
Sbjct: 5 TLFPGHGIGPEIXQAVXPI 23
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.316 0.136 0.382
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 528,943,600
Number of Sequences: 1657284
Number of extensions: 10507470
Number of successful extensions: 36288
Number of sequences better than 10.0: 133
Number of HSP's better than 10.0 without gapping: 34730
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 36128
length of database: 575,637,011
effective HSP length: 96
effective length of database: 416,537,747
effective search space used: 34989170748
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
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