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Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= brS-0521
         (656 letters)

Database: human 
           237,096 sequences; 76,859,062 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

X69078-1|CAA48822.1|  395|Homo sapiens methionine adenosyltransf...   217   2e-56
D49357-1|BAA08355.1|  395|Homo sapiens S-adenosylmethionine synt...   217   2e-56
BC018359-1|AAH18359.1|  395|Homo sapiens methionine adenosyltran...   217   2e-56
AL359195-2|CAI13695.1|  395|Homo sapiens methionine adenosyltran...   217   2e-56
X68836-1|CAA48726.1|  395|Homo sapiens S-adenosylmethionine synt...   214   2e-55
DQ083239-1|AAY85355.1|  395|Homo sapiens methionine adenosyltran...   214   2e-55
BC001854-1|AAH01854.1|  395|Homo sapiens methionine adenosyltran...   214   2e-55
BC001686-1|AAH01686.1|  395|Homo sapiens methionine adenosyltran...   214   2e-55
AC016753-1|AAY24339.1|  395|Homo sapiens unknown protein.             214   2e-55
L42451-1|AAC42010.1|  407|Homo sapiens pyruvate dehydrogenase ki...    30   8.3  
BC063137-1|AAH63137.1|  407|Homo sapiens pyruvate dehydrogenase ...    30   8.3  
BC040478-1|AAH40478.1|  407|Homo sapiens pyruvate dehydrogenase ...    30   8.3  
BC005811-1|AAH05811.1|  407|Homo sapiens pyruvate dehydrogenase ...    30   8.3  

>X69078-1|CAA48822.1|  395|Homo sapiens methionine
           adenosyltransferase protein.
          Length = 395

 Score =  217 bits (531), Expect = 2e-56
 Identities = 99/143 (69%), Positives = 118/143 (82%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAG+TGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVKAGLC
Sbjct: 252 IGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGVAEPLSI++F YGTS KT+++LL +V KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPLI 431
           Q+T+ YGHFGR+ FPWE P+ L+
Sbjct: 372 QKTACYGHFGRSEFPWEVPRKLV 394


>D49357-1|BAA08355.1|  395|Homo sapiens S-adenosylmethionine
           synthetase protein.
          Length = 395

 Score =  217 bits (531), Expect = 2e-56
 Identities = 99/143 (69%), Positives = 118/143 (82%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAG+TGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVKAGLC
Sbjct: 252 IGGPQGDAGVTGRKIIVDTYAAWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGVAEPLSI++F YGTS KT+++LL +V KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPLI 431
           Q+T+ YGHFGR+ FPWE P+ L+
Sbjct: 372 QKTACYGHFGRSEFPWEVPRKLV 394


>BC018359-1|AAH18359.1|  395|Homo sapiens methionine
           adenosyltransferase I, alpha protein.
          Length = 395

 Score =  217 bits (531), Expect = 2e-56
 Identities = 99/143 (69%), Positives = 118/143 (82%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAG+TGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVKAGLC
Sbjct: 252 IGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGVAEPLSI++F YGTS KT+++LL +V KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPLI 431
           Q+T+ YGHFGR+ FPWE P+ L+
Sbjct: 372 QKTACYGHFGRSEFPWEVPRKLV 394


>AL359195-2|CAI13695.1|  395|Homo sapiens methionine
           adenosyltransferase I, alpha protein.
          Length = 395

 Score =  217 bits (531), Expect = 2e-56
 Identities = 99/143 (69%), Positives = 118/143 (82%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAG+TGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVKAGLC
Sbjct: 252 IGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGVAEPLSI++F YGTS KT+++LL +V KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPLI 431
           Q+T+ YGHFGR+ FPWE P+ L+
Sbjct: 372 QKTACYGHFGRSEFPWEVPRKLV 394


>X68836-1|CAA48726.1|  395|Homo sapiens S-adenosylmethionine
           synthetase protein.
          Length = 395

 Score =  214 bits (523), Expect = 2e-55
 Identities = 99/142 (69%), Positives = 115/142 (80%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAGLTGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVK GLC
Sbjct: 252 IGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGV+ PLSI++F YGTS K++++LL IV+KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPL 428
           QRT+ YGHFGR  FPWE PK L
Sbjct: 372 QRTAAYGHFGRDSFPWEVPKKL 393


>DQ083239-1|AAY85355.1|  395|Homo sapiens methionine
           adenosyltransferase II protein.
          Length = 395

 Score =  214 bits (523), Expect = 2e-55
 Identities = 99/142 (69%), Positives = 115/142 (80%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAGLTGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVK GLC
Sbjct: 252 IGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGV+ PLSI++F YGTS K++++LL IV+KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPL 428
           QRT+ YGHFGR  FPWE PK L
Sbjct: 372 QRTAAYGHFGRDSFPWEVPKKL 393


>BC001854-1|AAH01854.1|  395|Homo sapiens methionine
           adenosyltransferase II, alpha protein.
          Length = 395

 Score =  214 bits (523), Expect = 2e-55
 Identities = 99/142 (69%), Positives = 115/142 (80%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAGLTGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVK GLC
Sbjct: 252 IGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGV+ PLSI++F YGTS K++++LL IV+KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPL 428
           QRT+ YGHFGR  FPWE PK L
Sbjct: 372 QRTAAYGHFGRDSFPWEVPKKL 393


>BC001686-1|AAH01686.1|  395|Homo sapiens methionine
           adenosyltransferase II, alpha protein.
          Length = 395

 Score =  214 bits (523), Expect = 2e-55
 Identities = 99/142 (69%), Positives = 115/142 (80%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAGLTGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVK GLC
Sbjct: 252 IGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGV+ PLSI++F YGTS K++++LL IV+KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPL 428
           QRT+ YGHFGR  FPWE PK L
Sbjct: 372 QRTAAYGHFGRDSFPWEVPKKL 393


>AC016753-1|AAY24339.1|  395|Homo sapiens unknown protein.
          Length = 395

 Score =  214 bits (523), Expect = 2e-55
 Identities = 99/142 (69%), Positives = 115/142 (80%)
 Frame = +3

Query: 3   IGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAKSLVKAGLC 182
           IGGPQ DAGLTGRKIIVDTY             KD+TKVDRSAAYAARWVAKSLVK GLC
Sbjct: 252 IGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLC 311

Query: 183 RRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIY 362
           RR +VQV+YAIGV+ PLSI++F YGTS K++++LL IV+KNFDLRPG IV++L+L+ PIY
Sbjct: 312 RRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIY 371

Query: 363 QRTSTYGHFGRAGFPWESPKPL 428
           QRT+ YGHFGR  FPWE PK L
Sbjct: 372 QRTAAYGHFGRDSFPWEVPKKL 393


>L42451-1|AAC42010.1|  407|Homo sapiens pyruvate dehydrogenase
           kinase protein.
          Length = 407

 Score = 29.9 bits (64), Expect = 8.3
 Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
 Frame = +3

Query: 144 RWVAKSLVKAGLCRRCMVQVAYAIGVAEPLSITVF-DYGTSHKTQQQLLSIVQKNFDLRP 320
           RWV   L  A L         ++     PLS+  F D+G+S+  ++   + +++   +R 
Sbjct: 2   RWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRL 61

Query: 321 GKIVKELNL 347
             I+KE+NL
Sbjct: 62  ANIMKEINL 70


>BC063137-1|AAH63137.1|  407|Homo sapiens pyruvate dehydrogenase
           kinase, isozyme 2 protein.
          Length = 407

 Score = 29.9 bits (64), Expect = 8.3
 Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
 Frame = +3

Query: 144 RWVAKSLVKAGLCRRCMVQVAYAIGVAEPLSITVF-DYGTSHKTQQQLLSIVQKNFDLRP 320
           RWV   L  A L         ++     PLS+  F D+G+S+  ++   + +++   +R 
Sbjct: 2   RWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRL 61

Query: 321 GKIVKELNL 347
             I+KE+NL
Sbjct: 62  ANIMKEINL 70


>BC040478-1|AAH40478.1|  407|Homo sapiens pyruvate dehydrogenase
           kinase, isozyme 2 protein.
          Length = 407

 Score = 29.9 bits (64), Expect = 8.3
 Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
 Frame = +3

Query: 144 RWVAKSLVKAGLCRRCMVQVAYAIGVAEPLSITVF-DYGTSHKTQQQLLSIVQKNFDLRP 320
           RWV   L  A L         ++     PLS+  F D+G+S+  ++   + +++   +R 
Sbjct: 2   RWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRL 61

Query: 321 GKIVKELNL 347
             I+KE+NL
Sbjct: 62  ANIMKEINL 70


>BC005811-1|AAH05811.1|  407|Homo sapiens pyruvate dehydrogenase
           kinase, isozyme 2 protein.
          Length = 407

 Score = 29.9 bits (64), Expect = 8.3
 Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
 Frame = +3

Query: 144 RWVAKSLVKAGLCRRCMVQVAYAIGVAEPLSITVF-DYGTSHKTQQQLLSIVQKNFDLRP 320
           RWV   L  A L         ++     PLS+  F D+G+S+  ++   + +++   +R 
Sbjct: 2   RWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRL 61

Query: 321 GKIVKELNL 347
             I+KE+NL
Sbjct: 62  ANIMKEINL 70


  Database: human
    Posted date:  Oct 23, 2007  1:18 PM
  Number of letters in database: 76,859,062
  Number of sequences in database:  237,096
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 95,499,493
Number of Sequences: 237096
Number of extensions: 2119176
Number of successful extensions: 4582
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 4359
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4582
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 7366354010
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)

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