BLASTX 2.2.12 [Aug-07-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= brS-0170 (756 letters) Database: uniref50 1,657,284 sequences; 575,637,011 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value UniRef50_Q9W4T4 Cluster: cAMP-specific 3',5'-cyclic phosphodiest... 194 2e-48 UniRef50_Q13945 Cluster: 3',5'-cyclic AMP phosphodiesterase; n=3... 159 5e-38 UniRef50_P27815 Cluster: cAMP-specific 3',5'-cyclic phosphodiest... 158 1e-37 UniRef50_UPI000065D378 Cluster: cAMP-specific 3',5'-cyclic phosp... 158 2e-37 UniRef50_Q4SP32 Cluster: Chromosome 15 SCAF14542, whole genome s... 158 2e-37 UniRef50_Q3UEI1-2 Cluster: Isoform 2 of Q3UEI1 ; n=1; Mus muscul... 149 7e-35 UniRef50_Q22000 Cluster: Probable 3',5'-cyclic phosphodiesterase... 144 3e-33 UniRef50_O96078 Cluster: EFPDE4; n=1; Ephydatia fluviatilis|Rep:... 127 3e-28 UniRef50_A7SVX8 Cluster: Predicted protein; n=1; Nematostella ve... 113 4e-24 UniRef50_O43862 Cluster: 3'5' cyclic nucleotide phosphodiesteras... 111 2e-23 UniRef50_O43851 Cluster: PDE4C-delta109; n=18; Bilateria|Rep: PD... 105 9e-22 UniRef50_Q9N2V9 Cluster: Probable 3',5'-cyclic phosphodiesterase... 104 3e-21 UniRef50_UPI0000D56A7E Cluster: PREDICTED: similar to High-affin... 103 6e-21 UniRef50_UPI0000519BD4 Cluster: PREDICTED: similar to phosphodie... 103 6e-21 UniRef50_A7SGA1 Cluster: Predicted protein; n=1; Nematostella ve... 103 6e-21 UniRef50_Q14123 Cluster: Calcium/calmodulin-dependent 3',5'-cycl... 102 8e-21 UniRef50_O95263 Cluster: High affinity cAMP-specific and IBMX-in... 102 1e-20 UniRef50_Q8CFW8 Cluster: Phosphodiesterase 8B; n=13; Euteleostom... 100 3e-20 UniRef50_UPI0000DB7125 Cluster: PREDICTED: similar to Phosphodie... 100 4e-20 UniRef50_O18696 Cluster: Probable 3',5'-cyclic phosphodiesterase... 100 4e-20 UniRef50_UPI0000DB6B8B Cluster: PREDICTED: similar to phosphodie... 100 8e-20 UniRef50_Q005X2 Cluster: Phosphodiesterase 1; n=1; Strongylocent... 100 8e-20 UniRef50_Q8SXR0 Cluster: RE69157p; n=9; Coelomata|Rep: RE69157p ... 99 1e-19 UniRef50_UPI0000E7FF0E Cluster: PREDICTED: similar to cAMP phosp... 98 2e-19 UniRef50_Q6NNF2 Cluster: SD02170p; n=9; Diptera|Rep: SD02170p - ... 98 2e-19 UniRef50_Q16J23 Cluster: Camp-specific 3,5-cyclic phosphodiester... 97 3e-19 UniRef50_O96075 Cluster: EFPDE1; n=1; Ephydatia fluviatilis|Rep:... 97 5e-19 UniRef50_Q13946 Cluster: High affinity cAMP-specific 3',5'-cycli... 96 7e-19 UniRef50_UPI00015B4893 Cluster: PREDICTED: similar to camp-speci... 95 1e-18 UniRef50_UPI00015B5210 Cluster: PREDICTED: similar to ENSANGP000... 92 2e-17 UniRef50_A4RV03 Cluster: Predicted protein; n=1; Ostreococcus lu... 92 2e-17 UniRef50_UPI000150A113 Cluster: 3''''5''''-cyclic nucleotide pho... 91 2e-17 UniRef50_Q4N806 Cluster: 3',5' cyclic nucleotide phosphodiestera... 91 2e-17 UniRef50_Q6S998 Cluster: CAMP-specific phosphodiesterase; n=3; L... 91 3e-17 UniRef50_A0EBQ7 Cluster: Chromosome undetermined scaffold_88, wh... 91 3e-17 UniRef50_A0CZ03 Cluster: Chromosome undetermined scaffold_31, wh... 91 4e-17 UniRef50_Q57V52 Cluster: 3', 5'-cyclic nucleotide phosphodiester... 90 6e-17 UniRef50_Q4D500 Cluster: Phosphodiesterase, putative; n=3; Trypa... 90 6e-17 UniRef50_A4HHP3 Cluster: Putative uncharacterized protein; n=3; ... 90 6e-17 UniRef50_Q1JT10 Cluster: Phosphodiesterase, putative; n=2; Eukar... 89 8e-17 UniRef50_Q23917 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 89 8e-17 UniRef50_UPI00006CBCA5 Cluster: 3''''5''''-cyclic nucleotide pho... 89 1e-16 UniRef50_Q54HY3 Cluster: Putative uncharacterized protein Pde4; ... 89 1e-16 UniRef50_Q8I6Y6 Cluster: CGMP-specific phosphodiesterase; n=3; D... 89 1e-16 UniRef50_Q388U6 Cluster: 3', 5'-cyclic nucleotide phosphodiester... 89 1e-16 UniRef50_UPI000150A9A4 Cluster: 3''''5''''-cyclic nucleotide pho... 88 2e-16 UniRef50_Q01C40 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostr... 88 3e-16 UniRef50_Q5CXM2 Cluster: Membrane associated HD superfamily cycl... 88 3e-16 UniRef50_Q23AZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 88 3e-16 UniRef50_A0DIM1 Cluster: Chromosome undetermined scaffold_52, wh... 87 3e-16 UniRef50_A0CU34 Cluster: Chromosome undetermined scaffold_28, wh... 87 4e-16 UniRef50_A4RUJ3 Cluster: Predicted protein; n=1; Ostreococcus lu... 86 8e-16 UniRef50_A0EHP5 Cluster: Chromosome undetermined scaffold_97, wh... 86 8e-16 UniRef50_Q2V2M6 Cluster: CGMP-specific phosphodiesterase; n=3; P... 86 1e-15 UniRef50_A5K0J4 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 86 1e-15 UniRef50_A0CG66 Cluster: Chromosome undetermined scaffold_179, w... 86 1e-15 UniRef50_A7AS42 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 85 1e-15 UniRef50_Q4KL87 Cluster: MGC116558 protein; n=2; Xenopus|Rep: MG... 85 2e-15 UniRef50_Q4RR95 Cluster: Chromosome 14 SCAF15003, whole genome s... 85 2e-15 UniRef50_A0EGK4 Cluster: Chromosome undetermined scaffold_95, wh... 85 2e-15 UniRef50_O89085 Cluster: cAMP-specific 3',5'-cyclic phosphodiest... 84 4e-15 UniRef50_O76083 Cluster: High affinity cGMP-specific 3',5'-cycli... 83 9e-15 UniRef50_Q4RH59 Cluster: Chromosome undetermined SCAF15069, whol... 82 1e-14 UniRef50_Q22CV4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 82 2e-14 UniRef50_A5JZK3 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 81 2e-14 UniRef50_Q23RI8 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 81 3e-14 UniRef50_A7SVS5 Cluster: Predicted protein; n=1; Nematostella ve... 81 4e-14 UniRef50_UPI0000D577EC Cluster: PREDICTED: similar to CG32648-PA... 80 7e-14 UniRef50_Q01CI7 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostr... 80 7e-14 UniRef50_A2DYU6 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 79 9e-14 UniRef50_Q9VYJ0 Cluster: CG32648-PA; n=3; Coelomata|Rep: CG32648... 79 2e-13 UniRef50_Q5C1P7 Cluster: SJCHGC07646 protein; n=1; Schistosoma j... 79 2e-13 UniRef50_Q7PQX7 Cluster: ENSANGP00000010843; n=6; Coelomata|Rep:... 78 2e-13 UniRef50_Q53I59 Cluster: Cyclic nucleotide specific phosphodiest... 78 2e-13 UniRef50_A0DF61 Cluster: Chromosome undetermined scaffold_49, wh... 78 2e-13 UniRef50_A0CB76 Cluster: Chromosome undetermined scaffold_163, w... 78 2e-13 UniRef50_Q16VA1 Cluster: High-affinity cgmp-specific 3,5-cyclic ... 78 3e-13 UniRef50_UPI00006CB6E9 Cluster: 3''''5''''-cyclic nucleotide pho... 77 4e-13 UniRef50_A2D762 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 77 4e-13 UniRef50_A2DJF3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 76 8e-13 UniRef50_Q6CHK1 Cluster: Similar to tr|Q8NJP9 Candida albicans H... 76 8e-13 UniRef50_UPI00015B464B Cluster: PREDICTED: similar to ENSANGP000... 76 1e-12 UniRef50_UPI0000E48F4D Cluster: PREDICTED: similar to camp and c... 76 1e-12 UniRef50_A2ERL4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 75 2e-12 UniRef50_A0EF18 Cluster: Chromosome undetermined scaffold_92, wh... 75 2e-12 UniRef50_A4VDP2 Cluster: Cyclic nucleotide phosphodiesterase; n=... 75 3e-12 UniRef50_Q4SV96 Cluster: Chromosome 10 SCAF13771, whole genome s... 69 3e-12 UniRef50_O96077 Cluster: EFPDE3; n=1; Ephydatia fluviatilis|Rep:... 74 3e-12 UniRef50_A7RXZ4 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 74 3e-12 UniRef50_A7AR41 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 73 6e-12 UniRef50_Q57ZK5 Cluster: 3', 5'-cyclic nucleotide phosphodiester... 73 1e-11 UniRef50_A2FKH2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 73 1e-11 UniRef50_A2ENJ2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 73 1e-11 UniRef50_A2G2M9 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 72 1e-11 UniRef50_A2E4B2 Cluster: Response regulator receiver domain cont... 72 1e-11 UniRef50_UPI0000D555D7 Cluster: PREDICTED: similar to phosphodie... 71 2e-11 UniRef50_Q4FXD4 Cluster: Putative uncharacterized protein; n=3; ... 71 2e-11 UniRef50_A5JZK2 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 71 2e-11 UniRef50_A0E2C5 Cluster: Chromosome undetermined scaffold_74, wh... 71 2e-11 UniRef50_UPI00006CF33D Cluster: 3''''5''''-cyclic nucleotide pho... 71 3e-11 UniRef50_Q4T098 Cluster: Chromosome undetermined SCAF11274, whol... 71 3e-11 UniRef50_Q8IKD3 Cluster: Cyclic nucleotide phosphodiesterase, pu... 71 3e-11 UniRef50_A2F9J4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 71 3e-11 UniRef50_O00408 Cluster: cGMP-dependent 3',5'-cyclic phosphodies... 71 3e-11 UniRef50_A2E8N2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 71 4e-11 UniRef50_A2DG30 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 71 4e-11 UniRef50_UPI000065CC62 Cluster: cGMP-inhibited 3',5'-cyclic phos... 70 5e-11 UniRef50_Q4RSB8 Cluster: Chromosome 13 SCAF15000, whole genome s... 70 5e-11 UniRef50_Q8I0P7 Cluster: Probable 3',5'-cyclic phosphodiesterase... 70 5e-11 UniRef50_A5K353 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 70 7e-11 UniRef50_A2FBN7 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 70 7e-11 UniRef50_A0E1V7 Cluster: Chromosome undetermined scaffold_74, wh... 70 7e-11 UniRef50_A2EIP4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 69 9e-11 UniRef50_Q4N6H0 Cluster: Putative uncharacterized protein; n=1; ... 69 1e-10 UniRef50_A0CZB5 Cluster: Chromosome undetermined scaffold_32, wh... 69 1e-10 UniRef50_O94034 Cluster: Nucleotide phosphodiesterase; n=4; Sacc... 60 1e-10 UniRef50_A2DF08 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 69 2e-10 UniRef50_Q14432 Cluster: cGMP-inhibited 3',5'-cyclic phosphodies... 69 2e-10 UniRef50_UPI0000D8B81A Cluster: UPI0000D8B81A related cluster; n... 68 3e-10 UniRef50_O96076 Cluster: EFPDE2; n=1; Ephydatia fluviatilis|Rep:... 68 3e-10 UniRef50_A2FQ29 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 68 3e-10 UniRef50_A2DNV4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 68 3e-10 UniRef50_P30645 Cluster: Probable 3',5'-cyclic phosphodiesterase... 67 4e-10 UniRef50_Q9HCR9 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphod... 67 4e-10 UniRef50_UPI00006A17C5 Cluster: cGMP-inhibited 3',5'-cyclic phos... 67 5e-10 UniRef50_Q4SI77 Cluster: Chromosome 5 SCAF14581, whole genome sh... 67 5e-10 UniRef50_Q7QRM3 Cluster: GLP_481_5888_1773; n=1; Giardia lamblia... 56 6e-10 UniRef50_Q3KVL8 Cluster: High-affinity phosphodiesterase; n=4; E... 57 6e-10 UniRef50_Q4RHZ1 Cluster: Chromosome 8 SCAF15044, whole genome sh... 66 7e-10 UniRef50_A2EY05 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 66 7e-10 UniRef50_Q13370 Cluster: cGMP-inhibited 3',5'-cyclic phosphodies... 66 7e-10 UniRef50_UPI0001554EBF Cluster: PREDICTED: similar to cyclic nuc... 66 9e-10 UniRef50_A3FQ29 Cluster: CGMP phosphodiesterase A4; n=2; Cryptos... 66 9e-10 UniRef50_A2DBZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 66 9e-10 UniRef50_UPI00015B4531 Cluster: PREDICTED: similar to cyclic GMP... 65 2e-09 UniRef50_Q6S996 Cluster: Class I phosphodiesterase PDEB1; n=21; ... 65 2e-09 UniRef50_A2F408 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 65 2e-09 UniRef50_A0BZK9 Cluster: Chromosome undetermined scaffold_139, w... 65 2e-09 UniRef50_A5DVX9 Cluster: Putative uncharacterized protein; n=1; ... 65 2e-09 UniRef50_Q3SBD3 Cluster: Sperm phosphodiesterase 5; n=1; Strongy... 64 3e-09 UniRef50_A2E0V4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 64 3e-09 UniRef50_A0D565 Cluster: Chromosome undetermined scaffold_38, wh... 64 3e-09 UniRef50_Q4SPD6 Cluster: Chromosome 16 SCAF14537, whole genome s... 64 4e-09 UniRef50_Q17L35 Cluster: Cgmp-dependent 3,5-cyclic phosphodieste... 64 4e-09 UniRef50_Q4SVG8 Cluster: Chromosome undetermined SCAF13758, whol... 63 6e-09 UniRef50_Q9VFI9 Cluster: CG8279-PA; n=8; Endopterygota|Rep: CG82... 63 6e-09 UniRef50_UPI0000588CD9 Cluster: PREDICTED: hypothetical protein;... 63 8e-09 UniRef50_Q7Q8G2 Cluster: ENSANGP00000013023; n=2; Diptera|Rep: E... 63 8e-09 UniRef50_UPI0000F1D4E2 Cluster: PREDICTED: similar to Phosphodie... 62 1e-08 UniRef50_A2EHB3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 62 1e-08 UniRef50_O76074 Cluster: cGMP-specific 3',5'-cyclic phosphodiest... 62 2e-08 UniRef50_Q9VJ79 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphod... 62 2e-08 UniRef50_Q4DUD4 Cluster: CAMP-specific phosphodiesterase, putati... 61 3e-08 UniRef50_A7TPP3 Cluster: Putative uncharacterized protein; n=1; ... 61 3e-08 UniRef50_P06776 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 61 3e-08 UniRef50_Q95Z92 Cluster: Possible phosphodiesterase; n=2; Leishm... 61 3e-08 UniRef50_Q6FM93 Cluster: Similar to sp|P06776 Saccharomyces cere... 61 3e-08 UniRef50_P16499 Cluster: Rod cGMP-specific 3',5'-cyclic phosphod... 60 4e-08 UniRef50_Q7YYN8 Cluster: Phosphdiesterase, possible; n=2; Crypto... 60 8e-08 UniRef50_A3FPW6 Cluster: Phosphdiesterase, putative; n=1; Crypto... 60 8e-08 UniRef50_A2FQB0 Cluster: GAF domain containing protein; n=1; Tri... 60 8e-08 UniRef50_Q16HU8 Cluster: Camp and camp-inhibited cgmp 3,5-cyclic... 59 1e-07 UniRef50_UPI000023CCA1 Cluster: hypothetical protein FG06914.1; ... 59 1e-07 UniRef50_A2DM77 Cluster: GAF domain containing protein; n=1; Tri... 59 1e-07 UniRef50_Q1DXU2 Cluster: Putative uncharacterized protein; n=1; ... 59 1e-07 UniRef50_Q4DJ46 Cluster: Putative uncharacterized protein; n=2; ... 58 2e-07 UniRef50_Q4SVG0 Cluster: Chromosome 1 SCAF13759, whole genome sh... 58 2e-07 UniRef50_A4RPY9 Cluster: Putative uncharacterized protein; n=1; ... 58 2e-07 UniRef50_A2FK96 Cluster: GAF domain containing protein; n=3; Tri... 58 3e-07 UniRef50_A2DM90 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 58 3e-07 UniRef50_Q9Y233 Cluster: cAMP and cAMP-inhibited cGMP 3',5'-cycl... 57 4e-07 UniRef50_Q6BSL2 Cluster: Similar to tr|O94034 Candida albicans N... 57 5e-07 UniRef50_A1D4A4 Cluster: High affinity cAMP phosphodiesterase, p... 57 5e-07 UniRef50_Q2H9G5 Cluster: Putative uncharacterized protein; n=1; ... 56 9e-07 UniRef50_Q0V6F8 Cluster: Putative uncharacterized protein; n=1; ... 56 9e-07 UniRef50_UPI0000E46CDB Cluster: PREDICTED: similar to phosphodie... 56 1e-06 UniRef50_A6S8A0 Cluster: Putative uncharacterized protein; n=2; ... 55 2e-06 UniRef50_A7SW30 Cluster: Predicted protein; n=2; Nematostella ve... 54 4e-06 UniRef50_A0BZW8 Cluster: Chromosome undetermined scaffold_14, wh... 54 4e-06 UniRef50_Q6CY30 Cluster: Similar to sp|P06776 Saccharomyces cere... 54 4e-06 UniRef50_UPI00006CD10E Cluster: 3''''5''''-cyclic nucleotide pho... 54 5e-06 UniRef50_Q7RXW7 Cluster: Putative uncharacterized protein NCU004... 54 5e-06 UniRef50_P91119 Cluster: Probable 3',5'-cyclic phosphodiesterase... 54 5e-06 UniRef50_Q758Y3 Cluster: ADR395Cp; n=1; Eremothecium gossypii|Re... 53 7e-06 UniRef50_A2FSQ8 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 52 2e-05 UniRef50_A6R1R4 Cluster: Predicted protein; n=1; Ajellomyces cap... 52 2e-05 UniRef50_A2FET3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 51 3e-05 UniRef50_A2EA57 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 50 5e-05 UniRef50_Q4RG61 Cluster: Chromosome 2 SCAF15106, whole genome sh... 50 6e-05 UniRef50_UPI000065E700 Cluster: Cone cGMP-specific 3',5'-cyclic ... 50 8e-05 UniRef50_Q22VA7 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 49 1e-04 UniRef50_A2GFY4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 48 3e-04 UniRef50_A0D3N1 Cluster: Chromosome undetermined scaffold_36, wh... 48 3e-04 UniRef50_Q4QE95 Cluster: Putative uncharacterized protein; n=3; ... 47 6e-04 UniRef50_UPI0000D56333 Cluster: PREDICTED: similar to cGMP-depen... 44 0.003 UniRef50_UPI000065DEB3 Cluster: Dual 3',5'-cyclic-AMP and -GMP p... 31 0.20 UniRef50_A4RH78 Cluster: Putative uncharacterized protein; n=1; ... 38 0.35 UniRef50_A7CYI8 Cluster: Two component transcriptional regulator... 37 0.62 UniRef50_A4RJX0 Cluster: Putative uncharacterized protein; n=2; ... 37 0.62 UniRef50_A5KSE4 Cluster: Putative uncharacterized protein; n=1; ... 36 1.4 UniRef50_Q5C091 Cluster: SJCHGC03341 protein; n=1; Schistosoma j... 36 1.4 UniRef50_Q9TXJ7 Cluster: Sperm specific transcript protein 20; n... 35 2.5 UniRef50_O27572 Cluster: Probable tRNA pseudouridine synthase D;... 35 2.5 UniRef50_UPI00006CB312 Cluster: hypothetical protein TTHERM_0045... 34 3.3 UniRef50_A6R697 Cluster: Predicted protein; n=1; Ajellomyces cap... 34 4.4 UniRef50_Q5N7R3 Cluster: Putative uncharacterized protein P0034C... 33 5.8 UniRef50_Q94241 Cluster: Putative uncharacterized protein; n=2; ... 33 5.8 UniRef50_A2FIR1 Cluster: Putative uncharacterized protein; n=1; ... 33 5.8 UniRef50_Q7SDI5 Cluster: Predicted protein; n=2; Sordariales|Rep... 33 5.8 UniRef50_Q4WB96 Cluster: Pectin methylesterase, putative; n=1; A... 31 5.9 UniRef50_A0VET3 Cluster: Conserved repeat domain precursor; n=1;... 33 7.6 >UniRef50_Q9W4T4 Cluster: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I; n=38; Coelomata|Rep: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I - Drosophila melanogaster (Fruit fly) Length = 1209 Score = 194 bits (473), Expect = 2e-48 Identities = 90/104 (86%), Positives = 95/104 (91%) Frame = +3 Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHD 623 FL S L++HY++DNPFHNSLHAADVTQSTNVLLNTPAL VFTPLEV ALFAAC+HD Sbjct: 853 FLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHD 912 Query: 624 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN G Sbjct: 913 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQG 956 Score = 187 bits (455), Expect = 3e-46 Identities = 99/164 (60%), Positives = 111/164 (67%), Gaps = 9/164 (5%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKK-------- 159 MLNKELSHFS+SS+SGNQISEYICSTFLDKQQE DLPSL+VE+ E A Sbjct: 697 MLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAG 756 Query: 160 EKPRHGGP-ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVD 336 + R P MSQISGVKR L+HTNSFTGER+P +GVETP D WG+ Sbjct: 757 QYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQ 816 Query: 337 IFRIGDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468 IF IG+ S RPLT VAYT F SRELLT+L IP +TFL F TL Sbjct: 817 IFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTL 860 >UniRef50_Q13945 Cluster: 3',5'-cyclic AMP phosphodiesterase; n=37; Coelomata|Rep: 3',5'-cyclic AMP phosphodiesterase - Homo sapiens (Human) Length = 606 Score = 159 bits (387), Expect = 5e-38 Identities = 76/110 (69%), Positives = 92/110 (83%) Frame = +3 Query: 423 SSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAAL 602 SSDT F+ L++HY D +HNSLHAADV QST+VLL+TPAL+AVFT LE+ AA+ Sbjct: 254 SSDT---FITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAI 310 Query: 603 FAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 FAA +HDVDHPG++NQFL+N++SELALMYNDESVLENHHLAV FKLLQ + Sbjct: 311 FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 360 Score = 119 bits (286), Expect = 9e-26 Identities = 61/155 (39%), Positives = 96/155 (61%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183 MLN+EL+H S+ S+SGNQ+SEYI +TFLDKQ ++++PS +++ +KK+K + Sbjct: 123 MLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPS-----PTQKDREKKKKQQ---- 173 Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363 M+QISGVK+ L H++S + R+GV T + ++WG++IF + S Sbjct: 174 --LMTQISGVKK-LMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH 230 Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468 RPLT + Y F R+LL T +I + TF+ + +TL Sbjct: 231 NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTL 265 >UniRef50_P27815 Cluster: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; n=160; Eumetazoa|Rep: cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Homo sapiens (Human) Length = 886 Score = 158 bits (384), Expect = 1e-37 Identities = 73/96 (76%), Positives = 85/96 (88%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 L++HY D +HNSLHAADV QST+VLL TPAL+AVFT LE+ AALFAA +HDVDHPG++ Sbjct: 422 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 481 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 NQFL+N++SELALMYNDESVLENHHLAV FKLLQ D Sbjct: 482 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 517 Score = 125 bits (302), Expect = 1e-27 Identities = 62/159 (38%), Positives = 96/159 (60%), Gaps = 4/159 (2%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183 MLN+EL+H S+ S+SGNQ+SEYI +TFLDKQ E+++PS ++E ++ A + + P Sbjct: 265 MLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPP 324 Query: 184 ATT----MSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIG 351 MSQI+G+K+ L H+NS +PR+GV+T ++WG++IF + Sbjct: 325 PVPHLQPMSQITGLKK-LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVS 383 Query: 352 DLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468 D + GR LT + Y F R+LL +IP T + + +TL Sbjct: 384 DYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTL 422 >UniRef50_UPI000065D378 Cluster: cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).; n=4; Euteleostomi|Rep: cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46). - Takifugu rubripes Length = 715 Score = 158 bits (383), Expect = 2e-37 Identities = 72/96 (75%), Positives = 86/96 (89%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 L++HY + +HNSLHAADVTQST+VLL+TPAL+AVFT LE+ AALFAA +HDVDHPG++ Sbjct: 391 LEDHYHANVAYHNSLHAADVTQSTHVLLSTPALDAVFTDLEILAALFAAAIHDVDHPGVS 450 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 NQFL+N++SELALMYNDESVLENHHLAV FKLL D Sbjct: 451 NQFLINTNSELALMYNDESVLENHHLAVGFKLLHED 486 Score = 129 bits (312), Expect = 6e-29 Identities = 67/155 (43%), Positives = 98/155 (63%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183 MLN+ELSH S+ S+SGNQ+SEYI +TFLDKQ E+++PS + E +EKP Sbjct: 254 MLNRELSHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTLRE--------REKP----- 300 Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363 M QISGVK+ LTH++S + +PR+GV+T H ++WG++IF + +LS Sbjct: 301 ---MCQISGVKK-LTHSSSLSNSALPRFGVKTEHEDALARELNDLNKWGLNIFHVAELSN 356 Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468 RPL+ + + F R+LL T +IP TF+ + +TL Sbjct: 357 NRPLSCIMFAIFQERDLLKTFRIPVDTFVTYVMTL 391 >UniRef50_Q4SP32 Cluster: Chromosome 15 SCAF14542, whole genome shotgun sequence; n=4; Tetraodontidae|Rep: Chromosome 15 SCAF14542, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 763 Score = 158 bits (383), Expect = 2e-37 Identities = 71/96 (73%), Positives = 85/96 (88%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 L+ HY + +HNSLHAADV QST++LL+TPALNAVFT LE+ AA+FAA +HDVDHPG++ Sbjct: 432 LESHYHSNVAYHNSLHAADVAQSTHILLSTPALNAVFTDLEILAAIFAAAIHDVDHPGVS 491 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 NQFL+N++SELALMYNDESVLENHHLAV FKLLQ D Sbjct: 492 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 527 Score = 127 bits (307), Expect = 3e-28 Identities = 67/164 (40%), Positives = 103/164 (62%), Gaps = 7/164 (4%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKK-------KE 162 MLN+ELSH S+ S+SGNQ+SEYI +TFLDKQ EL++P V ++ +R ++ ++ Sbjct: 273 MLNRELSHLSEMSRSGNQVSEYISNTFLDKQNELEIPC-PVPKSRDRKRRQGQQHQHQQQ 331 Query: 163 KPRHGGPATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIF 342 + +H M+QISGV++ L++T +G R+GV+T ++WG++IF Sbjct: 332 QQQHQQQGAMMTQISGVRK-LSNTPGTSGGPGNRFGVKTDQEELLSKDLEDINKWGINIF 390 Query: 343 RIGDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRS 474 R+ + S RPLT + YT F R+L+ T +IPA TF+ F +TL S Sbjct: 391 RVAEHSHNRPLTCIMYTIFQERDLMRTFKIPADTFVTFMLTLES 434 >UniRef50_Q3UEI1-2 Cluster: Isoform 2 of Q3UEI1 ; n=1; Mus musculus|Rep: Isoform 2 of Q3UEI1 - Mus musculus (Mouse) Length = 652 Score = 149 bits (361), Expect = 7e-35 Identities = 68/96 (70%), Positives = 80/96 (83%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 L+ HY D +HNS+HAADV QS +VLL TPAL AVFT LEV AA+FA +HDVDHPG++ Sbjct: 378 LEGHYHSDVAYHNSMHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVS 437 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 NQFL+N++SELALMYND SVLENHHLAV FKLLQ + Sbjct: 438 NQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGE 473 Score = 115 bits (276), Expect = 1e-24 Identities = 64/155 (41%), Positives = 96/155 (61%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183 MLN+ELS+ S++S+SGNQ+SEYI TFLD+Q E++LP + P P Sbjct: 242 MLNRELSYLSETSRSGNQVSEYISQTFLDQQAEVELP---------------QPPTEDDP 286 Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363 M+QI+ ++R+ +HT+ T +PR+GV+T ++WG+D+F++ +LS Sbjct: 287 -WPMAQITELRRS-SHTSLPTAA-IPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSG 343 Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468 RPLTAV ++ F R+LL T QIPA T LA+ +TL Sbjct: 344 NRPLTAVIFSVFQERDLLKTFQIPADTLLAYLLTL 378 >UniRef50_Q22000 Cluster: Probable 3',5'-cyclic phosphodiesterase pde-4; n=7; Caenorhabditis elegans|Rep: Probable 3',5'-cyclic phosphodiesterase pde-4 - Caenorhabditis elegans Length = 674 Score = 144 bits (348), Expect = 3e-33 Identities = 65/93 (69%), Positives = 78/93 (83%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650 EH+ R+N +HN +HAADV QS +VLL +P L VFT LEV AA+FA VHDVDHPG TNQ Sbjct: 398 EHHYRNNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQ 457 Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 +L+NS++ELA+MYNDESVLE HHLAVAFKLLQ+ Sbjct: 458 YLINSNNELAIMYNDESVLEQHHLAVAFKLLQD 490 Score = 87.8 bits (208), Expect = 3e-16 Identities = 54/160 (33%), Positives = 82/160 (51%), Gaps = 5/160 (3%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPR---- 171 MLNKELSHF++SSKSG Q+S+++ +T++DK++ D PS+++E +E P Sbjct: 245 MLNKELSHFAESSKSGTQVSKFLITTYMDKEE--DEPSIEIEVPTEVQGPSTSGPMTLSI 302 Query: 172 -HGGPATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRI 348 M++ISGV++ S G VP YGV D WG D+F+I Sbjct: 303 LKKAQTAAMNKISGVRK--LRAPSHDG-HVPEYGVNCAR--EIAVHMQRLDDWGPDVFKI 357 Query: 349 GDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468 +LS LT V ++ R L T +I T + + + L Sbjct: 358 DELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNL 397 >UniRef50_O96078 Cluster: EFPDE4; n=1; Ephydatia fluviatilis|Rep: EFPDE4 - Ephydatia fluviatilis Length = 698 Score = 127 bits (306), Expect = 3e-28 Identities = 60/102 (58%), Positives = 76/102 (74%) Frame = +3 Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHD 623 FL S ++ Y NP+HN+LHAADV +TN LL AL +FT LEV AAL AA +HD Sbjct: 398 FLNFISTIESKY-HSNPYHNALHAADVLLATNHLLKAKALEPIFTQLEVFAALVAAIIHD 456 Query: 624 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 VDHPG NQFLV++ LA++YNDESVLENHHLA+AF+L+++ Sbjct: 457 VDHPGRNNQFLVSTEDPLAILYNDESVLENHHLALAFELMKD 498 Score = 50.4 bits (115), Expect = 5e-05 Identities = 36/158 (22%), Positives = 72/158 (45%), Gaps = 1/158 (0%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICS-TFLDKQQELDLPSLQVEETSERGAKKKEKPRHGG 180 ++++EL+ S+ S SG++++E++ T D+ E+D ER + ++ P Sbjct: 261 VMSRELTQLSERSLSGHRVAEWVQDITRSDRDDEID-------RAIERSSIAEQDPEAQS 313 Query: 181 PATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLS 360 P T + + ++ + + V + + + + W +DIF + +S Sbjct: 314 PTTVVQPTAMLEGAASSVSQDLLHEVVKNKINSEDVTEFFKQ----EAWDMDIFLLDTVS 369 Query: 361 CGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRS 474 PL A AY F +R+L + ++I FL F T+ S Sbjct: 370 GNSPLVAAAYHVFKARDLFSEMKIVPSVFLNFISTIES 407 >UniRef50_A7SVX8 Cluster: Predicted protein; n=1; Nematostella vectensis|Rep: Predicted protein - Nematostella vectensis Length = 844 Score = 113 bits (272), Expect = 4e-24 Identities = 53/96 (55%), Positives = 67/96 (69%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ +Y R N +HNS HAADV +T V L + AV PL+ A+L AA VHDVDHPG T Sbjct: 570 IEANYHRKNAYHNSTHAADVLHATAVFLAKERVKAVLEPLDEVASLIAAIVHDVDHPGYT 629 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N FL N+ SELA++YND +VLE+HH A+AFKL D Sbjct: 630 NSFLCNAGSELAILYNDIAVLESHHAALAFKLTARD 665 >UniRef50_O43862 Cluster: 3'5' cyclic nucleotide phosphodiesterase 4D splice variant 1; n=8; Euteleostomi|Rep: 3'5' cyclic nucleotide phosphodiesterase 4D splice variant 1 - Homo sapiens (Human) Length = 205 Score = 111 bits (267), Expect = 2e-23 Identities = 57/132 (43%), Positives = 86/132 (65%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183 MLN+EL+H S+ S+SGNQ+SE+I +TFLDKQ E+++PS +++ +KK++P Sbjct: 87 MLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPS-----PTQKEKEKKKRP----- 136 Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363 MSQISGVK+ L H++S T +PR+GV+T ++WG+ +FRI +LS Sbjct: 137 ---MSQISGVKK-LMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSG 192 Query: 364 GRPLTAVAYTAF 399 RPLT + +T F Sbjct: 193 NRPLTVIMHTIF 204 >UniRef50_O43851 Cluster: PDE4C-delta109; n=18; Bilateria|Rep: PDE4C-delta109 - Homo sapiens (Human) Length = 427 Score = 105 bits (253), Expect = 9e-22 Identities = 47/60 (78%), Positives = 55/60 (91%) Frame = +3 Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 AVFT LE+ AALFA+ +HDVDHPG++NQFL+N++SELALMYND SVLENHHLAV FKLLQ Sbjct: 126 AVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQ 185 Score = 99.1 bits (236), Expect = 1e-19 Identities = 55/148 (37%), Positives = 87/148 (58%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183 +LN+EL+H S++S+SGNQ+SEYI TFLD+Q E++LP + EE + Sbjct: 10 ILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ-------------- 55 Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363 MS+ISG+ L H+ S + VPR+GV+T ++WG+D+F++ +LS Sbjct: 56 --PMSRISGL-HGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSG 112 Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTF 447 +PLTA+ ++ F + + T L+I A F Sbjct: 113 NQPLTAIIFSIF--QAVFTDLEILAALF 138 >UniRef50_Q9N2V9 Cluster: Probable 3',5'-cyclic phosphodiesterase pde-6; n=3; Caenorhabditis|Rep: Probable 3',5'-cyclic phosphodiesterase pde-6 - Caenorhabditis elegans Length = 760 Score = 104 bits (249), Expect = 3e-21 Identities = 44/92 (47%), Positives = 64/92 (69%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ HY N +HN+ HAADV Q+T+ L++P++ AAL AA VHD+DHPG Sbjct: 491 IEAHYHAGNTYHNATHAADVLQATSFFLDSPSVAVHVNESHAVAALLAAAVHDLDHPGRG 550 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 N +L+N+ LA++YND S+LENHH+A+AF+L Sbjct: 551 NAYLINTRQSLAILYNDNSILENHHIALAFQL 582 >UniRef50_UPI0000D56A7E Cluster: PREDICTED: similar to High-affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A; n=1; Tribolium castaneum|Rep: PREDICTED: similar to High-affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A - Tribolium castaneum Length = 862 Score = 103 bits (246), Expect = 6e-21 Identities = 46/96 (47%), Positives = 63/96 (65%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ +Y DN +HNS HAADV Q+T L L ++ PL+ +L AA HDVDHPG + Sbjct: 568 IEANYHTDNTYHNSTHAADVMQATAGFLEREKLKSIMDPLDEATSLIAAAAHDVDHPGKS 627 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N FL NS + LA++YND ++LE+HH A+ FKL D Sbjct: 628 NAFLSNSDNPLAILYNDITILESHHAALMFKLTLGD 663 >UniRef50_UPI0000519BD4 Cluster: PREDICTED: similar to phosphodiesterase 8A; n=1; Apis mellifera|Rep: PREDICTED: similar to phosphodiesterase 8A - Apis mellifera Length = 820 Score = 103 bits (246), Expect = 6e-21 Identities = 46/96 (47%), Positives = 65/96 (67%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ +Y N +HNS HAADV Q+ + + T L V PL+ A L AA HD+DHPG + Sbjct: 525 IEANYDITNRYHNSTHAADVLQAAAMFMQTERLKQVLEPLDEVATLIAAAAHDIDHPGRS 584 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 +QFL NS ++LA++YND +VLE+HH A+ FKL +D Sbjct: 585 SQFLCNSDNKLAILYNDLTVLESHHAALTFKLTLSD 620 >UniRef50_A7SGA1 Cluster: Predicted protein; n=1; Nematostella vectensis|Rep: Predicted protein - Nematostella vectensis Length = 358 Score = 103 bits (246), Expect = 6e-21 Identities = 44/88 (50%), Positives = 62/88 (70%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NP+HN HAADVT + + L ++ + LEV L +A +HD++H G TN F +NS Sbjct: 137 NPYHNDCHAADVTHTVHYFLECMGVSKYLSDLEVFGLLLSAIIHDLEHTGTTNAFHINSR 196 Query: 669 SELALMYNDESVLENHHLAVAFKLLQND 752 S+LAL+YND SVLENHH++ AF++LQ+D Sbjct: 197 SDLALLYNDRSVLENHHVSCAFRILQDD 224 >UniRef50_Q14123 Cluster: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; n=128; Euteleostomi|Rep: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C - Homo sapiens (Human) Length = 709 Score = 102 bits (245), Expect = 8e-21 Identities = 44/88 (50%), Positives = 63/88 (71%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NP+HN +HAADVTQ+ + LL + T LE+ A +F+A +HD +H G TN F + + Sbjct: 225 NPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTR 284 Query: 669 SELALMYNDESVLENHHLAVAFKLLQND 752 S+ A++YND SVLENHHL+ A++LLQ+D Sbjct: 285 SDPAILYNDRSVLENHHLSAAYRLLQDD 312 >UniRef50_O95263 Cluster: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; n=83; Euteleostomi|Rep: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B - Homo sapiens (Human) Length = 885 Score = 102 bits (244), Expect = 1e-20 Identities = 48/96 (50%), Positives = 62/96 (64%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ +Y N +HNS HAADV +T L + L+ AAL AA VHDVDHPG T Sbjct: 604 IEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRT 663 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N FL N+ SELA++YND +VLE+HH A+AF+L D Sbjct: 664 NSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 699 >UniRef50_Q8CFW8 Cluster: Phosphodiesterase 8B; n=13; Euteleostomi|Rep: Phosphodiesterase 8B - Mus musculus (Mouse) Length = 730 Score = 100 bits (240), Expect = 3e-20 Identities = 47/96 (48%), Positives = 61/96 (63%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ +Y N +HNS HAADV +T L + L+ AAL AA VHDVDHPG T Sbjct: 449 IEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRT 508 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N FL N+ SELA++YND +VLE+HH A+ F+L D Sbjct: 509 NSFLCNAGSELAVLYNDTAVLESHHTALVFQLTVKD 544 >UniRef50_UPI0000DB7125 Cluster: PREDICTED: similar to Phosphodiesterase 1c CG14940-PA; n=1; Apis mellifera|Rep: PREDICTED: similar to Phosphodiesterase 1c CG14940-PA - Apis mellifera Length = 731 Score = 100 bits (239), Expect = 4e-20 Identities = 46/97 (47%), Positives = 66/97 (68%), Gaps = 1/97 (1%) Frame = +3 Query: 465 LKEHYIRD-NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641 ++E Y R NP+HN+LHAADV Q+ + +L L T LE+ A L AA +HD +H G Sbjct: 429 VEEGYCRHRNPYHNNLHAADVAQTMHYILCQTGLMNWLTDLEIFATLVAAIIHDYEHTGT 488 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 TN F V S S+ AL+YND +VLENHH++ +F++++ D Sbjct: 489 TNNFHVMSGSDTALLYNDRAVLENHHISASFRIMRED 525 >UniRef50_O18696 Cluster: Probable 3',5'-cyclic phosphodiesterase pde-1; n=2; Caenorhabditis|Rep: Probable 3',5'-cyclic phosphodiesterase pde-1 - Caenorhabditis elegans Length = 664 Score = 100 bits (239), Expect = 4e-20 Identities = 43/89 (48%), Positives = 62/89 (69%) Frame = +3 Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665 +NP+HN +HAADVTQS++ +L+ L LE+ A LF A +HD +H G TN F + S Sbjct: 329 NNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQS 388 Query: 666 SSELALMYNDESVLENHHLAVAFKLLQND 752 S+ A++YND SVLENHH++ F+L++ D Sbjct: 389 QSQFAMLYNDRSVLENHHVSSCFRLMKED 417 >UniRef50_UPI0000DB6B8B Cluster: PREDICTED: similar to phosphodiesterase 7A isoform a; n=1; Apis mellifera|Rep: PREDICTED: similar to phosphodiesterase 7A isoform a - Apis mellifera Length = 1148 Score = 99.5 bits (237), Expect = 8e-20 Identities = 49/123 (39%), Positives = 69/123 (56%) Frame = +3 Query: 387 VHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN 566 VH H G + Y + + ++++E Y NP+HNS+HA DVTQ+ + L + Sbjct: 60 VHLFHWYGLLQYFNLDVVTVWKLFAFIEEGYHSTNPYHNSIHATDVTQAMHCFLQEEKIR 119 Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 T LE+ A+L AA HD+DHPG+ FLV +S+ LA +Y + SVLENHH A L Sbjct: 120 THLTNLEIMASLIAAVTHDLDHPGVNQPFLVATSNHLAALYQNTSVLENHHWRSAIGCLL 179 Query: 747 NDG 755 G Sbjct: 180 ESG 182 >UniRef50_Q005X2 Cluster: Phosphodiesterase 1; n=1; Strongylocentrotus purpuratus|Rep: Phosphodiesterase 1 - Strongylocentrotus purpuratus (Purple sea urchin) Length = 680 Score = 99.5 bits (237), Expect = 8e-20 Identities = 43/88 (48%), Positives = 64/88 (72%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NP+HN LHAADVTQ+ + +L L + LE+ A+L AA +HD +H G TN F VN+ Sbjct: 283 NPYHNLLHAADVTQTVHHMLARMGLVHWLSDLEIFASLLAAIIHDFEHTGTTNAFHVNTK 342 Query: 669 SELALMYNDESVLENHHLAVAFKLLQND 752 S++A+ YND +VLENHH++ +F+L+++D Sbjct: 343 SDMAMFYNDRAVLENHHISSSFRLMRDD 370 >UniRef50_Q8SXR0 Cluster: RE69157p; n=9; Coelomata|Rep: RE69157p - Drosophila melanogaster (Fruit fly) Length = 834 Score = 98.7 bits (235), Expect = 1e-19 Identities = 48/97 (49%), Positives = 64/97 (65%), Gaps = 1/97 (1%) Frame = +3 Query: 465 LKEHYIR-DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641 ++E Y R NP+HN+LHA DV Q+ + L L T LE+ A+L AA +HD +H G Sbjct: 457 VEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGT 516 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 TN F V S SE AL+YND +VLENHH + +F+LL+ D Sbjct: 517 TNNFHVMSGSETALLYNDRAVLENHHASASFRLLRED 553 >UniRef50_UPI0000E7FF0E Cluster: PREDICTED: similar to cAMP phosphodiesterase PDE7, partial; n=1; Gallus gallus|Rep: PREDICTED: similar to cAMP phosphodiesterase PDE7, partial - Gallus gallus Length = 482 Score = 98.3 bits (234), Expect = 2e-19 Identities = 44/97 (45%), Positives = 62/97 (63%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++E Y NP+HN++HAADVTQ+ + L P L+ TP +V +L AA HD+DHPG+ Sbjct: 2 VQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLSESLTPWDVLLSLIAAATHDLDHPGVN 61 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 FL+ ++ LA +Y + SVLENHH A LL+ G Sbjct: 62 QPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG 98 Score = 64.5 bits (150), Expect = 3e-09 Identities = 29/69 (42%), Positives = 42/69 (60%) Frame = +3 Query: 549 NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728 ++ L+ TP +V +L AA HD+DHPG+ FL+ ++ LA +Y + SVLENHH Sbjct: 227 HSECLSESLTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRS 286 Query: 729 AFKLLQNDG 755 A LL+ G Sbjct: 287 AVGLLRESG 295 >UniRef50_Q6NNF2 Cluster: SD02170p; n=9; Diptera|Rep: SD02170p - Drosophila melanogaster (Fruit fly) Length = 914 Score = 97.9 bits (233), Expect = 2e-19 Identities = 47/98 (47%), Positives = 61/98 (62%), Gaps = 2/98 (2%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLN--TPALNAVFTPLEVCAALFAACVHDVDHPG 638 ++ HY + N +HNS HAADV Q+T + T V +E AL AA HDVDHPG Sbjct: 629 IEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPG 688 Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 ++ FL NS+ LA++YND +VLENHH A+ FKL D Sbjct: 689 RSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGD 726 >UniRef50_Q16J23 Cluster: Camp-specific 3,5-cyclic phosphodiesterase; n=2; Culicidae|Rep: Camp-specific 3,5-cyclic phosphodiesterase - Aedes aegypti (Yellowfever mosquito) Length = 872 Score = 97.5 bits (232), Expect = 3e-19 Identities = 48/123 (39%), Positives = 69/123 (56%) Frame = +3 Query: 387 VHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN 566 VH H G +D+ + + S ++E Y NP+HNS+HA DVTQ+ + L + Sbjct: 131 VHLFHWYGLLDHFNLDVVRVWKLFSLIEEGYHSTNPYHNSIHATDVTQAMHCFLQEKRIL 190 Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 +PLE+ A+L A HD+DHPG+ FL+ +S+ LA +Y + SVLENHH A L Sbjct: 191 ENLSPLEIMASLIGAVTHDLDHPGVNQPFLIATSNHLAALYENTSVLENHHWRSAVGCLL 250 Query: 747 NDG 755 G Sbjct: 251 ESG 253 >UniRef50_O96075 Cluster: EFPDE1; n=1; Ephydatia fluviatilis|Rep: EFPDE1 - Ephydatia fluviatilis Length = 628 Score = 96.7 bits (230), Expect = 5e-19 Identities = 45/93 (48%), Positives = 62/93 (66%) Frame = +3 Query: 474 HYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQF 653 + + NP+HNS HAADV Q+ + L+++ L + LEV A L AA VHD++H G TN F Sbjct: 271 YQLHGNPYHNSTHAADVLQTVHYLISSTGLEHWISSLEVLAILLAATVHDLEHTGTTNTF 330 Query: 654 LVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 + S ++ AL+YND +VLEN HL AF LL+ D Sbjct: 331 HIQSYTDYALLYNDRAVLENFHLNRAFTLLKED 363 >UniRef50_Q13946 Cluster: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; n=73; Euteleostomi|Rep: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A - Homo sapiens (Human) Length = 482 Score = 96.3 bits (229), Expect = 7e-19 Identities = 43/97 (44%), Positives = 61/97 (62%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++E Y NP+HN++HAADVTQ+ + L P L TP ++ +L AA HD+DHPG+ Sbjct: 201 IQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVN 260 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 FL+ ++ LA +Y + SVLENHH A LL+ G Sbjct: 261 QPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG 297 >UniRef50_UPI00015B4893 Cluster: PREDICTED: similar to camp-specific 3,5-cyclic phosphodiesterase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar to camp-specific 3,5-cyclic phosphodiesterase - Nasonia vitripennis Length = 1229 Score = 95.5 bits (227), Expect = 1e-18 Identities = 48/123 (39%), Positives = 70/123 (56%) Frame = +3 Query: 387 VHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN 566 VH H G +++ + + + ++E Y NP+HNS+HAADVTQ+ + L + Sbjct: 255 VHLFHWYGLLEHFNLDVVRVWKLFTLIEEGYHSTNPYHNSIHAADVTQAMHCFLQEEQIR 314 Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 + LE+ A+L AA HD+DHPG+ FLV +S+ LA +Y + SVLENHH A L Sbjct: 315 RHLSYLEIMASLIAAVTHDLDHPGVNQPFLVATSNHLAALYENTSVLENHHWRSAVGCLL 374 Query: 747 NDG 755 G Sbjct: 375 ESG 377 >UniRef50_UPI00015B5210 Cluster: PREDICTED: similar to ENSANGP00000018818; n=2; Nasonia vitripennis|Rep: PREDICTED: similar to ENSANGP00000018818 - Nasonia vitripennis Length = 849 Score = 91.9 bits (218), Expect = 2e-17 Identities = 40/96 (41%), Positives = 63/96 (65%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ +Y +HNS HA DV Q+ + + + + PL+ AAL AA HD+ HPG + Sbjct: 568 IEANYNSHVSYHNSTHATDVLQACARFMRSDRIQQILDPLDEVAALLAAAAHDIGHPGKS 627 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 +QFL N+S++LA++YND +VLE+HH A+ FK+ +D Sbjct: 628 SQFLCNTSNKLAILYNDLTVLESHHSALTFKVTLSD 663 >UniRef50_A4RV03 Cluster: Predicted protein; n=1; Ostreococcus lucimarinus CCE9901|Rep: Predicted protein - Ostreococcus lucimarinus CCE9901 Length = 401 Score = 91.9 bits (218), Expect = 2e-17 Identities = 44/94 (46%), Positives = 59/94 (62%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650 E RDNP+H HA DVT +T + + T +E+ + L AA VHD+DHPG+TN Sbjct: 62 EGMYRDNPYHCFKHAVDVTHTTYLYICAVKEQVSMTQVEIFSLLVAALVHDLDHPGVTNG 121 Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 +L+ + +AL YNDESVLEN HL+ F L QN+ Sbjct: 122 YLIATHDNIALTYNDESVLENLHLSRFFSLCQNN 155 >UniRef50_UPI000150A113 Cluster: 3''''5''''-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3''''5''''-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 569 Score = 91.5 bits (217), Expect = 2e-17 Identities = 40/98 (40%), Positives = 65/98 (66%), Gaps = 2/98 (2%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPG 638 +++ Y+ NP+HN +HA DVTQ+ + L + +++ AA +HDV+HPG Sbjct: 256 IQQKYL-GNPYHNKIHAFDVTQTMHFFLKKCNFVQIGKLNKIDIGTVFVAAAIHDVEHPG 314 Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N F +N+ ++LA++YND+S LENHHL+V FKLL+++ Sbjct: 315 FNNPFQMNAKTDLAILYNDKSPLENHHLSVTFKLLRDN 352 >UniRef50_Q4N806 Cluster: 3',5' cyclic nucleotide phosphodiesterase, putative; n=2; Theileria|Rep: 3',5' cyclic nucleotide phosphodiesterase, putative - Theileria parva Length = 450 Score = 91.5 bits (217), Expect = 2e-17 Identities = 44/121 (36%), Positives = 71/121 (58%) Frame = +3 Query: 390 HSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNA 569 H +H G + + + + V L++HY+ NP+HN+LHAA V + +L N Sbjct: 136 HLLHCVGNLIHPN-FNTNLIPVLQNLQQHYLA-NPYHNALHAATVGHMSKLLSNIVTTKR 193 Query: 570 VFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 P E A + ++ HDV HPG TN +L N+S+ L+L+YND S LEN+H ++ F +++N Sbjct: 194 RLNPYEEFAFIISSLAHDVGHPGKTNNYLSNTSNVLSLIYNDNSTLENYHCSLLFYIIKN 253 Query: 750 D 752 + Sbjct: 254 N 254 >UniRef50_Q6S998 Cluster: CAMP-specific phosphodiesterase; n=3; Leishmania|Rep: CAMP-specific phosphodiesterase - Leishmania major Length = 631 Score = 91.1 bits (216), Expect = 3e-17 Identities = 41/89 (46%), Positives = 60/89 (67%), Gaps = 2/89 (2%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 NP+HNS+HAADV Q T+ ++ L + ++V +AL AA +HD DHPG+ N F + Sbjct: 382 NPYHNSMHAADVLQITDFIITQGGLAKRCDLSDIQVFSALLAASIHDFDHPGINNNFHIK 441 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749 + S LA +YND SVLEN H++ F+L++N Sbjct: 442 TGSYLATLYNDRSVLENLHVSSVFELMKN 470 >UniRef50_A0EBQ7 Cluster: Chromosome undetermined scaffold_88, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_88, whole genome shotgun sequence - Paramecium tetraurelia Length = 744 Score = 91.1 bits (216), Expect = 3e-17 Identities = 43/99 (43%), Positives = 63/99 (63%) Frame = +3 Query: 456 CSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635 C ++ Y++ NP+HNS+HA DV S + L TP E C + +A HDV HP Sbjct: 453 CHRIESFYMQ-NPYHNSIHAMDVANSASFFLEN---GLEVTPFEQCCLIISALSHDVGHP 508 Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 GL N FLV S S+ AL+YND+SVLE++H ++ F +L+++ Sbjct: 509 GLNNGFLVASQSKQALIYNDQSVLESYHASLMFHVLKDE 547 >UniRef50_A0CZ03 Cluster: Chromosome undetermined scaffold_31, whole genome shotgun sequence; n=4; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_31, whole genome shotgun sequence - Paramecium tetraurelia Length = 692 Score = 90.6 bits (215), Expect = 4e-17 Identities = 46/100 (46%), Positives = 60/100 (60%), Gaps = 4/100 (4%) Frame = +3 Query: 453 VCSYLKE--HYIRDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVH 620 V SY +E +DNP+HN +HA DV Q+ N LLN + ++ L A +H Sbjct: 417 VRSYFEEVMRGYQDNPYHNRVHAQDVAQTCNFLLNRCKFIEIGQLDEQDIACVLIAGAIH 476 Query: 621 DVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 D HPGLTN FL+NS +ELAL YND+SVLE H + FK+ Sbjct: 477 DYGHPGLTNAFLINSKNELALTYNDQSVLEMFHPSQCFKI 516 >UniRef50_Q57V52 Cluster: 3', 5'-cyclic nucleotide phosphodiesterase, putative; n=3; Trypanosoma|Rep: 3', 5'-cyclic nucleotide phosphodiesterase, putative - Trypanosoma brucei Length = 676 Score = 89.8 bits (213), Expect = 6e-17 Identities = 41/89 (46%), Positives = 57/89 (64%), Gaps = 2/89 (2%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALN--AVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 NP+HNS+HAADVTQ ++ + P E A+ AA VHD DHPGL N F Sbjct: 428 NPYHNSMHAADVTQVNYYIIFIAGMKERCQLRPEEQLGAVLAAAVHDFDHPGLNNNFHTR 487 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749 +++ L+ +YND S+LENHH+A F+LL++ Sbjct: 488 TNAYLSTLYNDRSILENHHIASVFQLLKH 516 >UniRef50_Q4D500 Cluster: Phosphodiesterase, putative; n=3; Trypanosoma cruzi|Rep: Phosphodiesterase, putative - Trypanosoma cruzi Length = 708 Score = 89.8 bits (213), Expect = 6e-17 Identities = 40/89 (44%), Positives = 61/89 (68%), Gaps = 2/89 (2%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 NP+HNS+HAADV T+ +L+ + + L+V AALFAA +HD +HPG+ N F + Sbjct: 459 NPYHNSMHAADVLHITHYILSKGGMIERCQLSDLQVFAALFAAAIHDYNHPGVNNNFHIK 518 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749 + + A++YND SVLEN H++ F+L++N Sbjct: 519 TQTYSAIVYNDRSVLENAHVSSVFELMKN 547 >UniRef50_A4HHP3 Cluster: Putative uncharacterized protein; n=3; Leishmania|Rep: Putative uncharacterized protein - Leishmania braziliensis Length = 734 Score = 89.8 bits (213), Expect = 6e-17 Identities = 41/89 (46%), Positives = 56/89 (62%), Gaps = 2/89 (2%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNA--VFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 NP+HN++H ADVTQ ++ L+ + E+ A + A VHD DHPGL N F Sbjct: 459 NPYHNAMHGADVTQINYYIMIVAGLSVKCCLSNEEIFAGIIAGAVHDFDHPGLNNNFHSR 518 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749 + + LA +YND S+LENHHLA F+LL+N Sbjct: 519 TGAYLATLYNDRSILENHHLACTFELLRN 547 >UniRef50_Q1JT10 Cluster: Phosphodiesterase, putative; n=2; Eukaryota|Rep: Phosphodiesterase, putative - Toxoplasma gondii RH Length = 2092 Score = 89.4 bits (212), Expect = 8e-17 Identities = 42/97 (43%), Positives = 57/97 (58%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 +++ Y DNP+HN HA V Q + L+ + +P+E L AA HDVDHPG+ Sbjct: 1747 IRDGYHTDNPYHNFYHAIHVFQVCWMFLSAYGCRNILSPIEQLGILLAALCHDVDHPGVN 1806 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N FL S L++MYND+SVLENHH A A + + G Sbjct: 1807 NAFLRASLHPLSIMYNDKSVLENHHAAFAIRTMMQLG 1843 >UniRef50_Q23917 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase regA; n=2; Dictyostelium discoideum|Rep: 3',5'-cyclic-nucleotide phosphodiesterase regA - Dictyostelium discoideum (Slime mold) Length = 793 Score = 89.4 bits (212), Expect = 8e-17 Identities = 41/91 (45%), Positives = 57/91 (62%) Frame = +3 Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656 Y ++N +HN HA DVTQ+ L + T L++ A L + HD++HPG N F Sbjct: 480 YRKNNRYHNFTHAFDVTQTVYTFLTSFNAAQYLTHLDIFALLISCMCHDLNHPGFNNTFQ 539 Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQN 749 VN+ +EL+L YND SVLENHH + FK+L+N Sbjct: 540 VNAQTELSLEYNDISVLENHHAMLTFKILRN 570 >UniRef50_UPI00006CBCA5 Cluster: 3''''5''''-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3''''5''''-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 649 Score = 89.0 bits (211), Expect = 1e-16 Identities = 40/90 (44%), Positives = 55/90 (61%), Gaps = 2/90 (2%) Frame = +3 Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALN--AVFTPLEVCAALFAACVHDVDHPGLTNQFLV 659 DN +HN LHA DV Q+ N L + A ++C +A HD DHPG+ N F++ Sbjct: 379 DNLYHNRLHAFDVLQTANFFLKSCNFIEIAAINEFDLCTIYISAACHDYDHPGVNNAFII 438 Query: 660 NSSSELALMYNDESVLENHHLAVAFKLLQN 749 N+S E+AL YND+SVLENHH + F+L + Sbjct: 439 NTSHEIALTYNDQSVLENHHASKTFQLFND 468 >UniRef50_Q54HY3 Cluster: Putative uncharacterized protein Pde4; n=2; Dictyostelium discoideum|Rep: Putative uncharacterized protein Pde4 - Dictyostelium discoideum AX4 Length = 771 Score = 89.0 bits (211), Expect = 1e-16 Identities = 39/93 (41%), Positives = 58/93 (62%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++ Y NP+HNS+HA DV + N + + T +E+ + + AA +HD HPG+ Sbjct: 330 IESGYDSTNPYHNSIHATDVLHNLNYFIEK-SFGKFLTDIELFSMILAAIIHDFKHPGVN 388 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 N F +NS S LAL YND+S+LEN+HL AF ++ Sbjct: 389 NHFQINSKSRLALKYNDKSILENYHLHQAFIIM 421 >UniRef50_Q8I6Y6 Cluster: CGMP-specific phosphodiesterase; n=3; Dictyostelium discoideum|Rep: CGMP-specific phosphodiesterase - Dictyostelium discoideum (Slime mold) Length = 522 Score = 88.6 bits (210), Expect = 1e-16 Identities = 37/89 (41%), Positives = 62/89 (69%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 R+NPFH+ HA VTQ+ ++L L + +P+E + + A+ HD+DHP L+N+F +N Sbjct: 264 RNNPFHSFNHAIAVTQTIFLILLKTNLFNILSPIEKLSIIIASICHDLDHPALSNRFQIN 323 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749 S +A++YN++SVLENHHL++ +L++ Sbjct: 324 MKSSIAVLYNNKSVLENHHLSICLGILES 352 >UniRef50_Q388U6 Cluster: 3', 5'-cyclic nucleotide phosphodiesterase, putative; n=2; Trypanosoma brucei|Rep: 3', 5'-cyclic nucleotide phosphodiesterase, putative - Trypanosoma brucei Length = 620 Score = 88.6 bits (210), Expect = 1e-16 Identities = 42/89 (47%), Positives = 59/89 (66%), Gaps = 2/89 (2%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 NP+HNS+HAADV T+ LL+ L + +V AALFAA +HD +HPG+ N F + Sbjct: 368 NPYHNSMHAADVLHITHYLLSKGGLAELCKLNDRQVLAALFAAAIHDYNHPGINNNFSIL 427 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749 + + A +YND SVLEN H+A F+L++N Sbjct: 428 TQTYNATLYNDRSVLENMHVASVFELMRN 456 >UniRef50_UPI000150A9A4 Cluster: 3''''5''''-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3''''5''''-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 929 Score = 88.2 bits (209), Expect = 2e-16 Identities = 48/117 (41%), Positives = 63/117 (53%), Gaps = 1/117 (0%) Frame = +3 Query: 399 HITGAVDYSSDTGAYFLGVCSYLKEHYI-RDNPFHNSLHAADVTQSTNVLLNTPALNAVF 575 H+ G +D FL L+ Y R NPFHN HA V+ +T +N L Sbjct: 625 HLAGFMDKLKIDKEVFLKFLQLLQHKYDKRQNPFHNFQHAIAVSHATYFFINAKFLARYL 684 Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 LE LF++ HDV H G TN F V + S+LA+ +NDESVLENHH + FK++Q Sbjct: 685 DYLEQFTLLFSSLGHDVSHTGRTNAFEVATLSKLAIKFNDESVLENHHSSTLFKIIQ 741 >UniRef50_Q01C40 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostreococcus tauri|Rep: Cyclic GMP phosphodiesterase - Ostreococcus tauri Length = 674 Score = 87.8 bits (208), Expect = 3e-16 Identities = 42/94 (44%), Positives = 58/94 (61%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650 E RDNP+H HA DV +T + + + LE+ + L AA VHD+DHPG+TN Sbjct: 302 ESMYRDNPYHCFKHAFDVAHTTYLYILAVKDQVEMSQLEIFSLLVAALVHDLDHPGVTNA 361 Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 +L+ + +A+ YNDESVLEN HL+ F L QN+ Sbjct: 362 YLIATRDSIAMTYNDESVLENLHLSRFFTLCQNN 395 >UniRef50_Q5CXM2 Cluster: Membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein; n=2; Cryptosporidium|Rep: Membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein - Cryptosporidium parvum Iowa II Length = 1967 Score = 87.8 bits (208), Expect = 3e-16 Identities = 42/93 (45%), Positives = 53/93 (56%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 + + Y D P+HN HA V Q ++L + V L LFAA HD+DHPG+ Sbjct: 1541 IHDSYNSDIPYHNIFHALQVVQVCYIILRNFGIMLVLNDLNKFILLFAALCHDIDHPGVN 1600 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 N FL S+S+LAL YND S+LENHH F LL Sbjct: 1601 NCFLTISNSKLALKYNDNSILENHHCNYIFSLL 1633 >UniRef50_Q23AZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 577 Score = 87.8 bits (208), Expect = 3e-16 Identities = 40/102 (39%), Positives = 65/102 (63%), Gaps = 2/102 (1%) Frame = +3 Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN--AVFTPLEVCAALFAACV 617 F+ + ++ Y RDNP+H+ LH+ DVTQ+ + ++ A +E A F+A + Sbjct: 294 FINLSVRIQNGY-RDNPYHDRLHSFDVTQTIHFFISRCKFGELAKLKSMERAAMYFSAAI 352 Query: 618 HDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 HD DHPG N FL+N+ + LAL +ND+SVLENHH++ ++++ Sbjct: 353 HDFDHPGYNNVFLINTQNILALKFNDQSVLENHHVSSVYEMI 394 >UniRef50_A0DIM1 Cluster: Chromosome undetermined scaffold_52, whole genome shotgun sequence; n=3; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_52, whole genome shotgun sequence - Paramecium tetraurelia Length = 779 Score = 87.4 bits (207), Expect = 3e-16 Identities = 45/119 (37%), Positives = 61/119 (51%), Gaps = 1/119 (0%) Frame = +3 Query: 399 HITGAVDYSSDTGAYFLGVCSYLKEHY-IRDNPFHNSLHAADVTQSTNVLLNTPALNAVF 575 H+ +D F ++E Y R NPFHN H V + ++ + ++N F Sbjct: 494 HLCNFIDLYQINKEVFYQFTVIVQEKYSYRQNPFHNYDHGFTVAHACYYIIKSKSMNQYF 553 Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 AL +A HD+DH G N F S+LAL YNDESVLENHH +V FK+LQ + Sbjct: 554 DKFIQFTALLSALCHDIDHTGRNNHFESQKLSKLALRYNDESVLENHHASVMFKILQKE 612 >UniRef50_A0CU34 Cluster: Chromosome undetermined scaffold_28, whole genome shotgun sequence; n=4; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_28, whole genome shotgun sequence - Paramecium tetraurelia Length = 903 Score = 87.0 bits (206), Expect = 4e-16 Identities = 43/101 (42%), Positives = 57/101 (56%), Gaps = 1/101 (0%) Frame = +3 Query: 444 FLGVCSYLKEHYIRD-NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVH 620 F+ + LK Y + NPFHN H +V + + P F + A A H Sbjct: 629 FINFLTALKYKYNKTANPFHNFTHGVNVMHGCFLFTHHPKFGFCFNDQQRFAMTLAGLCH 688 Query: 621 DVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 DV HPG N F VN+ ++LAL+YND+SVLENHH+AV +KLL Sbjct: 689 DVGHPGTNNLFQVNTQTKLALLYNDKSVLENHHIAVTYKLL 729 >UniRef50_A4RUJ3 Cluster: Predicted protein; n=1; Ostreococcus lucimarinus CCE9901|Rep: Predicted protein - Ostreococcus lucimarinus CCE9901 Length = 614 Score = 86.2 bits (204), Expect = 8e-16 Identities = 45/92 (48%), Positives = 55/92 (59%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650 E RDN +HN +HA DVTQ+ L+ T +L + P+ A L AA HDV HPG+ N Sbjct: 346 ERKYRDNDYHNRVHATDVTQAAAYLIET-SLESQIEPIHTFAMLVAAMSHDVGHPGVNNT 404 Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 FLVN S A +ND SV EN HL AF LL+ Sbjct: 405 FLVNCKSAEAERWNDVSVNENGHLFTAFSLLK 436 >UniRef50_A0EHP5 Cluster: Chromosome undetermined scaffold_97, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_97, whole genome shotgun sequence - Paramecium tetraurelia Length = 908 Score = 86.2 bits (204), Expect = 8e-16 Identities = 42/97 (43%), Positives = 58/97 (59%), Gaps = 1/97 (1%) Frame = +3 Query: 465 LKEHY-IRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641 ++E Y R NPFHN H V + ++ L+ E AA+ ++ HD+DH G Sbjct: 653 IEERYNSRRNPFHNFEHGFTVAHACYYMIKNKLLDEYLDQTEQFAAILSSLCHDIDHTGR 712 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 TN F V S+LA+ YNDESVLENHH A+AFK++Q + Sbjct: 713 TNGFEVARMSKLAVRYNDESVLENHHAAMAFKIMQRE 749 >UniRef50_Q2V2M6 Cluster: CGMP-specific phosphodiesterase; n=3; Plasmodium|Rep: CGMP-specific phosphodiesterase - Plasmodium falciparum Length = 884 Score = 85.8 bits (203), Expect = 1e-15 Identities = 42/92 (45%), Positives = 56/92 (60%), Gaps = 1/92 (1%) Frame = +3 Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPL-EVCAALFAACVHDVDHPGLTNQF 653 Y D P+H SLHAA V + +L +N + + E C + + C HD HPGL N F Sbjct: 603 YYNDIPYHTSLHAAQVAHFSKSMLFMLDMNHKISAIDEFCLHISSLC-HDTGHPGLNNYF 661 Query: 654 LVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 L+NS + LAL YND SVLEN+H ++ FK L+N Sbjct: 662 LINSENNLALTYNDNSVLENYHCSLLFKTLKN 693 >UniRef50_A5K0J4 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase, putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide phosphodiesterase, putative - Plasmodium vivax Length = 1001 Score = 85.8 bits (203), Expect = 1e-15 Identities = 45/96 (46%), Positives = 59/96 (61%), Gaps = 2/96 (2%) Frame = +3 Query: 465 LKEHYI-RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPL-EVCAALFAACVHDVDHPG 638 LK H + D P+HNSLHAA V + +L +N + E C + + C HDV HPG Sbjct: 715 LKMHSLYNDVPYHNSLHAAQVAHFSKSMLFLLDINHKIPAIDEFCLHVSSLC-HDVGHPG 773 Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 L N FL+NS + LAL YND SVLEN+H ++ FK L+ Sbjct: 774 LNNYFLINSENNLALTYNDNSVLENYHCSLVFKTLK 809 >UniRef50_A0CG66 Cluster: Chromosome undetermined scaffold_179, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_179, whole genome shotgun sequence - Paramecium tetraurelia Length = 1056 Score = 85.8 bits (203), Expect = 1e-15 Identities = 41/90 (45%), Positives = 52/90 (57%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 R NPFHN H V QS N L + P + + + A + + HD+ H G TNQF +N Sbjct: 790 RKNPFHNFDHGITVMQSCNFLCSLPRAHEYISEIVYFATVISGLCHDISHTGRTNQFEIN 849 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQND 752 S S+LA Y D+S LENHH AV KLL+ D Sbjct: 850 SKSKLATRYLDKSPLENHHAAVTLKLLKQD 879 >UniRef50_A7AS42 Cluster: 3'5'-cyclic nucleotide phosphodiesterase, putative; n=1; Babesia bovis|Rep: 3'5'-cyclic nucleotide phosphodiesterase, putative - Babesia bovis Length = 485 Score = 85.4 bits (202), Expect = 1e-15 Identities = 42/98 (42%), Positives = 62/98 (63%) Frame = +3 Query: 453 VCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDH 632 V + +++ Y+ NP+HN+LH A V + VLL +L TPLE A L AA HD H Sbjct: 197 VLNSIQDVYL-PNPYHNALHGACVAHMSCVLLKALSLEQYLTPLEQFAYLIAALGHDAGH 255 Query: 633 PGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 PG TN FL ++ + LAL+YND S+LEN+H ++ +++ Sbjct: 256 PGKTNAFLRSTQNPLALIYNDASILENYHASLVCHIIR 293 >UniRef50_Q4KL87 Cluster: MGC116558 protein; n=2; Xenopus|Rep: MGC116558 protein - Xenopus laevis (African clawed frog) Length = 342 Score = 85.0 bits (201), Expect = 2e-15 Identities = 37/93 (39%), Positives = 62/93 (66%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 +++HY ++NPFHN H VTQ +++ L + +++ + AA HD+DHPGL+ Sbjct: 81 VQKHY-QENPFHNFYHGFSVTQMMYCVISQCQLQEHLSHIDILTLMVAALCHDLDHPGLS 139 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 N + VN+ ++LA Y+++S LENHH AVA+++L Sbjct: 140 NSYQVNAQTDLARQYHNKSPLENHHWAVAWRIL 172 >UniRef50_Q4RR95 Cluster: Chromosome 14 SCAF15003, whole genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 14 SCAF15003, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 456 Score = 84.6 bits (200), Expect = 2e-15 Identities = 45/110 (40%), Positives = 62/110 (56%), Gaps = 6/110 (5%) Frame = +3 Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHD 623 FLG+ ++E Y NP+HN++HAADVTQ+ L P L +PL+V L AA HD Sbjct: 175 FLGM---VQEDYHSQNPYHNAVHAADVTQAMYCYLKEPKLAEQLSPLDVFLGLMAAAAHD 231 Query: 624 VDHPGLTNQFLVNSSSELALMY------NDESVLENHHLAVAFKLLQNDG 755 VDHPG+ FL+ + LA +Y + SVLE+HH +L+ G Sbjct: 232 VDHPGVNQPFLIKTRHHLASLYQVHQSVQNTSVLESHHWRSTVGMLRESG 281 >UniRef50_A0EGK4 Cluster: Chromosome undetermined scaffold_95, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_95, whole genome shotgun sequence - Paramecium tetraurelia Length = 756 Score = 84.6 bits (200), Expect = 2e-15 Identities = 39/89 (43%), Positives = 56/89 (62%) Frame = +3 Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665 +N +HNSLHA DV ST LN L+A E + ++ HD+ HPGL N F+ + Sbjct: 480 NNLYHNSLHALDVANSTAFFLNN-GLDAQLDEFEFACLIVSSLAHDLGHPGLNNGFMTTN 538 Query: 666 SSELALMYNDESVLENHHLAVAFKLLQND 752 +LAL+YND+SVLEN+H + F++LQ + Sbjct: 539 RCKLALLYNDQSVLENYHSFLLFQILQQE 567 >UniRef50_O89085 Cluster: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; n=3; Euteleostomi|Rep: cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Cavia porcellus (Guinea pig) Length = 117 Score = 83.8 bits (198), Expect = 4e-15 Identities = 42/96 (43%), Positives = 64/96 (66%), Gaps = 4/96 (4%) Frame = +1 Query: 4 MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183 MLN+EL+H S+ S+SGNQ+SEYI +TFLDKQ E+++PS +++ + A ++ + P Sbjct: 13 MLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKDREPQEAPRQRPCQQLPP 72 Query: 184 AT----TMSQISGVKRTLTHTNSFTGERVPRYGVET 279 MSQI+GVKR L+H + +PR+GV+T Sbjct: 73 PVPHLQPMSQITGVKR-LSHNSGLNNASIPRFGVKT 107 >UniRef50_O76083 Cluster: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; n=62; Eumetazoa|Rep: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A - Homo sapiens (Human) Length = 593 Score = 82.6 bits (195), Expect = 9e-15 Identities = 45/121 (37%), Positives = 64/121 (52%) Frame = +3 Query: 381 CRVHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPA 560 C H H G V S + ++Y R+NPFHN H V Q ++ + Sbjct: 274 CLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNY-RNNPFHNFRHCFCVAQMMYSMVWLCS 332 Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 L F+ ++ + AA HD+DHPG N + +N+ +ELA+ YND S LENHH AVAF++ Sbjct: 333 LQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI 392 Query: 741 L 743 L Sbjct: 393 L 393 >UniRef50_Q4RH59 Cluster: Chromosome undetermined SCAF15069, whole genome shotgun sequence; n=3; Euteleostomi|Rep: Chromosome undetermined SCAF15069, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 695 Score = 82.2 bits (194), Expect = 1e-14 Identities = 45/110 (40%), Positives = 64/110 (58%), Gaps = 22/110 (20%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NP+HN +HAADVTQ+ + LL + T LE+ A +FAA VHD +H G TN F + +S Sbjct: 282 NPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTS 341 Query: 669 ----------------------SELALMYNDESVLENHHLAVAFKLLQND 752 S+ A++YND SVLE+HH++ A++LLQ+D Sbjct: 342 SAKYTSCICPVQLQQDPKNEIKSDTAILYNDRSVLESHHVSAAYRLLQDD 391 >UniRef50_Q22CV4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 1258 Score = 81.8 bits (193), Expect = 2e-14 Identities = 36/93 (38%), Positives = 55/93 (59%) Frame = +3 Query: 468 KEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647 K++ I++N FHN H V QS +L V P+++ + + HDV H G TN Sbjct: 884 KQYDIKNNDFHNFDHGVSVMQSCYMLSKCQRATQVLKPIDIFTVILSGLCHDVGHTGRTN 943 Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 F ++ S+LA+ Y+D+SVLE HHLA FK+++ Sbjct: 944 NFEISVQSKLAIRYHDKSVLEQHHLATTFKIMK 976 >UniRef50_A5JZK3 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase, putative; n=7; Plasmodium|Rep: 3',5'-cyclic-nucleotide phosphodiesterase, putative - Plasmodium vivax Length = 783 Score = 81.4 bits (192), Expect = 2e-14 Identities = 40/93 (43%), Positives = 59/93 (63%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 +KE Y + P+HN +HAA V + N+L+N + E+ A L AA HD+ H G T Sbjct: 491 MKEGY-NNVPYHNCIHAAMVAEQCNILVNNLDTANILRDNEMAAFLLAALGHDIGHFGRT 549 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 N FL NSS+ L+++YND+S+LEN+H + F +L Sbjct: 550 NLFLKNSSNFLSVIYNDKSILENYHCSYLFHIL 582 >UniRef50_Q23RI8 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 807 Score = 81.0 bits (191), Expect = 3e-14 Identities = 37/92 (40%), Positives = 55/92 (59%), Gaps = 2/92 (2%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPGLTNQFL 656 +DN +HN +HA DVTQ+ + + + + + LE+ AA HD HPG N +L Sbjct: 538 QDNFYHNKMHAFDVTQTMHYFMQSLNFIGIADLSGLEIGLMYIAAAAHDYQHPGFNNPYL 597 Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQND 752 +N+ +ELA+ YND+S LENHH F L+Q + Sbjct: 598 INTRNELAIRYNDKSPLENHHAFSTFLLMQEE 629 >UniRef50_A7SVS5 Cluster: Predicted protein; n=1; Nematostella vectensis|Rep: Predicted protein - Nematostella vectensis Length = 496 Score = 80.6 bits (190), Expect = 4e-14 Identities = 41/93 (44%), Positives = 54/93 (58%) Frame = +3 Query: 474 HYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQF 653 HY PFHN HA VTQ L+ + T ++ L +A HD+DHPG N + Sbjct: 218 HY-NPTPFHNFRHAFCVTQMMYGLIWLTEIFNKITKQDLLIMLTSALCHDLDHPGYNNAY 276 Query: 654 LVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 +N+ +ELAL YND S LENHH AVAF +++ D Sbjct: 277 QINARTELALRYNDISPLENHHCAVAFDIMKQD 309 >UniRef50_UPI0000D577EC Cluster: PREDICTED: similar to CG32648-PA; n=2; Coelomata|Rep: PREDICTED: similar to CG32648-PA - Tribolium castaneum Length = 938 Score = 79.8 bits (188), Expect = 7e-14 Identities = 41/100 (41%), Positives = 58/100 (58%), Gaps = 2/100 (2%) Frame = +3 Query: 459 SYLKEHY--IRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDH 632 ++L E Y D PFHN H V Q + + L + LEV L + HD+DH Sbjct: 232 NFLYEAYKNYNDVPFHNFRHCFCVAQMMYAISWSVDLPSKVGDLEVLILLTSCICHDLDH 291 Query: 633 PGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 PG N + +N+ +ELA+ YND S LENHH +VAF++L+N+ Sbjct: 292 PGYNNIYQINAKTELAIRYNDISPLENHHCSVAFRILENE 331 >UniRef50_Q01CI7 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostreococcus tauri|Rep: Cyclic GMP phosphodiesterase - Ostreococcus tauri Length = 526 Score = 79.8 bits (188), Expect = 7e-14 Identities = 40/88 (45%), Positives = 55/88 (62%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 RDN +HN +HAADVTQ+ + T +L P+ + A L +A VHDV HPGL N +LV Sbjct: 259 RDNDYHNGVHAADVTQAAAYFIET-SLRDQIEPIHIFALLLSAVVHDVGHPGLNNAYLVA 317 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQ 746 +++A +N+ SV EN HL A LL+ Sbjct: 318 RQTDVAERWNNVSVNENGHLYTANTLLK 345 >UniRef50_A2DYU6 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1091 Score = 79.4 bits (187), Expect = 9e-14 Identities = 35/89 (39%), Positives = 52/89 (58%) Frame = +3 Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665 D P+HN +HA DVT+ L T + + +PLE A L +A HD +H G N F + + Sbjct: 817 DVPYHNWMHACDVTEYVAYELKTSGFDEMLSPLEKFALLLSAVCHDANHEGFNNIFNIKA 876 Query: 666 SSELALMYNDESVLENHHLAVAFKLLQND 752 + L L++ D SV+E HHL V+ +L +D Sbjct: 877 QTPLGLLFKDTSVMETHHLTVSIDILSDD 905 >UniRef50_Q9VYJ0 Cluster: CG32648-PA; n=3; Coelomata|Rep: CG32648-PA - Drosophila melanogaster (Fruit fly) Length = 963 Score = 78.6 bits (185), Expect = 2e-13 Identities = 40/94 (42%), Positives = 56/94 (59%), Gaps = 1/94 (1%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGLTN 647 +HY + PFHN H V Q + L + LE C L +C+ HD+DHPG N Sbjct: 103 KHY-NEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLE-CLILLVSCICHDLDHPGYNN 160 Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 + +N+ +ELAL YND S LENHH ++AF+LL++ Sbjct: 161 IYQINARTELALRYNDISPLENHHCSIAFRLLEH 194 >UniRef50_Q5C1P7 Cluster: SJCHGC07646 protein; n=1; Schistosoma japonicum|Rep: SJCHGC07646 protein - Schistosoma japonicum (Blood fluke) Length = 219 Score = 78.6 bits (185), Expect = 2e-13 Identities = 35/60 (58%), Positives = 46/60 (76%) Frame = +3 Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 + ++ T ++ A L AA VHDVDHPG TN FLVNS+ LA++YND +VLE+HH AVAF+L Sbjct: 7 IRSICTNIDEVATLLAAIVHDVDHPGKTNPFLVNSNDPLAILYNDIAVLESHHAAVAFEL 66 >UniRef50_Q7PQX7 Cluster: ENSANGP00000010843; n=6; Coelomata|Rep: ENSANGP00000010843 - Anopheles gambiae str. PEST Length = 547 Score = 78.2 bits (184), Expect = 2e-13 Identities = 40/93 (43%), Positives = 53/93 (56%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650 +HY D PFHN H V Q + L LEV L + HD+DHPG N Sbjct: 92 KHY-NDVPFHNYRHCFCVAQMMYTIAWHTNLVQRLGELEVLVLLVSCICHDLDHPGYNNI 150 Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 + +N+ +ELAL YND S LENHH ++AF+LL++ Sbjct: 151 YQINARTELALRYNDISPLENHHCSIAFRLLEH 183 >UniRef50_Q53I59 Cluster: Cyclic nucleotide specific phosphodiesterase; n=3; Trypanosoma cruzi|Rep: Cyclic nucleotide specific phosphodiesterase - Trypanosoma cruzi Length = 924 Score = 78.2 bits (184), Expect = 2e-13 Identities = 41/92 (44%), Positives = 53/92 (57%), Gaps = 1/92 (1%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPA-LNAVFTPLEVCAALFAACVHDVDHPGLTN 647 E+ R NP+HN++HAADV Q T L++ L TPLE AA FAA HDV HPG TN Sbjct: 359 ENNYRPNPYHNAIHAADVLQGTFSLVSAAKPLMEHLTPLECKAAAFAALTHDVCHPGRTN 418 Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 FL ++ ++ + LE H AF+LL Sbjct: 419 AFLAAVQDPVSFKFSGKGTLEQLHTVTAFELL 450 >UniRef50_A0DF61 Cluster: Chromosome undetermined scaffold_49, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_49, whole genome shotgun sequence - Paramecium tetraurelia Length = 768 Score = 78.2 bits (184), Expect = 2e-13 Identities = 38/99 (38%), Positives = 57/99 (57%) Frame = +3 Query: 447 LGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDV 626 LG S E ++N +HNS+HA DV ST L L+ + + L ++ HD+ Sbjct: 478 LGEFSVKIESLYQNNFYHNSMHAIDVANSTAFFLQN-GLSTLIDDFQATCLLISSLAHDI 536 Query: 627 DHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 HPGL N F+ + LAL++ND+SVLEN+H + F++L Sbjct: 537 GHPGLNNGFMTANRCRLALLFNDQSVLENYHSFLLFQVL 575 >UniRef50_A0CB76 Cluster: Chromosome undetermined scaffold_163, whole genome shotgun sequence; n=3; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_163, whole genome shotgun sequence - Paramecium tetraurelia Length = 619 Score = 78.2 bits (184), Expect = 2e-13 Identities = 36/92 (39%), Positives = 52/92 (56%), Gaps = 2/92 (2%) Frame = +3 Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPGLTNQ 650 Y +DN +HN +HA DVT + + + T ++ L +A HD DHPGL N Sbjct: 360 YHKDNLYHNVIHAFDVTHTVYFFIQKCNFKEIGKLTKIDYSILLMSAAAHDADHPGLNNI 419 Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 FL N+ +LA+ YND+S LE HH A F+ ++ Sbjct: 420 FLSNTRHDLAMTYNDKSPLEQHHAATLFRYIR 451 >UniRef50_Q16VA1 Cluster: High-affinity cgmp-specific 3,5-cyclic phosphodiesterase; n=1; Aedes aegypti|Rep: High-affinity cgmp-specific 3,5-cyclic phosphodiesterase - Aedes aegypti (Yellowfever mosquito) Length = 1022 Score = 77.8 bits (183), Expect = 3e-13 Identities = 40/93 (43%), Positives = 53/93 (56%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650 +HY D PFHN H V Q + L LEV L + HD+DHPG N Sbjct: 97 KHY-NDVPFHNYRHCFCVAQMMYAITWHTNLVQRLGELEVLILLVSCICHDLDHPGYNNI 155 Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 + +N+ +ELAL YND S LENHH ++AF+LL++ Sbjct: 156 YQINARTELALRYNDISPLENHHCSIAFRLLEH 188 >UniRef50_UPI00006CB6E9 Cluster: 3''''5''''-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3''''5''''-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 699 Score = 77.4 bits (182), Expect = 4e-13 Identities = 37/88 (42%), Positives = 49/88 (55%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 R NPFHN H V +L + + A +F+ HDV H TN F VN Sbjct: 302 RGNPFHNFDHGITVMHGCYMLCCQTVAQTIIKEINEFALIFSGLCHDVSHTARTNLFEVN 361 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQ 746 S S+LA+ Y+D+SVLE HH+AV FK+L+ Sbjct: 362 SMSKLAIRYHDKSVLEQHHIAVTFKILR 389 >UniRef50_A2D762 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=2; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1081 Score = 77.4 bits (182), Expect = 4e-13 Identities = 36/96 (37%), Positives = 55/96 (57%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++E Y + P+HN +H DV Q ++T L+ V+ PLE+ A AA HD H GL Sbjct: 821 IREKY-NEVPYHNWMHCVDVCQYLAYEVSTAELDKVYKPLELLAMFVAAVCHDAGHEGLN 879 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N + V + + L +++ D+SV+E HH VA LL + Sbjct: 880 NIYNVKAETPLGILFKDQSVMETHHCTVAISLLTKE 915 >UniRef50_A2DJF3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1006 Score = 76.2 bits (179), Expect = 8e-13 Identities = 33/87 (37%), Positives = 52/87 (59%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA DVTQ + L + + P+E+ A L AA HDV+H G TN + + + Sbjct: 755 PYHNWRHAVDVTQFVSYQLVVSGVYKILKPIELYALLIAAICHDVNHDGFTNVYNEKAET 814 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L +++ ++SV+E HH VA +++ ND Sbjct: 815 PLGILFKNQSVMETHHCQVAIQVVSND 841 >UniRef50_Q6CHK1 Cluster: Similar to tr|Q8NJP9 Candida albicans High affinity cAMP phosphodiesterase; n=1; Yarrowia lipolytica|Rep: Similar to tr|Q8NJP9 Candida albicans High affinity cAMP phosphodiesterase - Yarrowia lipolytica (Candida lipolytica) Length = 626 Score = 76.2 bits (179), Expect = 8e-13 Identities = 43/112 (38%), Positives = 62/112 (55%), Gaps = 19/112 (16%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQST-------------------NVLLNTPALNAVFTPLE 587 +++ Y +NP+HN HA DV Q+T N + P AVFTP E Sbjct: 349 MRDAYHHENPYHNFRHAIDVMQATFQFLIRLGCLPPPPFKRAPNCSMIPPIGPAVFTPAE 408 Query: 588 VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 + AA HD+ HPG+TN FLV+S S +A ++ND+SVLE++H V ++L Sbjct: 409 SLVVIIAAIGHDISHPGVTNAFLVSSHSPMAQVFNDKSVLESYHACVLNRVL 460 >UniRef50_UPI00015B464B Cluster: PREDICTED: similar to ENSANGP00000010843; n=1; Nasonia vitripennis|Rep: PREDICTED: similar to ENSANGP00000010843 - Nasonia vitripennis Length = 801 Score = 75.8 bits (178), Expect = 1e-12 Identities = 35/85 (41%), Positives = 49/85 (57%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 PFHN H V Q ++ + + LEV + + HD+DHPG N + +N+ + Sbjct: 545 PFHNFRHCFCVAQMLYIITGSVNTKSRIGDLEVLVLIVSCICHDLDHPGYNNIYQINART 604 Query: 672 ELALMYNDESVLENHHLAVAFKLLQ 746 ELAL YND S LENHH +VAF +L+ Sbjct: 605 ELALRYNDISPLENHHCSVAFHILE 629 >UniRef50_UPI0000E48F4D Cluster: PREDICTED: similar to camp and camp-inhibited cgmp 3,5-cyclic phosphodiesterase; n=2; Strongylocentrotus purpuratus|Rep: PREDICTED: similar to camp and camp-inhibited cgmp 3,5-cyclic phosphodiesterase - Strongylocentrotus purpuratus Length = 1197 Score = 75.8 bits (178), Expect = 1e-12 Identities = 42/98 (42%), Positives = 60/98 (61%), Gaps = 1/98 (1%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641 ++++Y R P+HN HA V S ++ T VF PLE A LF AC+ HD+DH G Sbjct: 24 VRKNY-RRVPYHNWTHAFSVAHSVYTMIMT-GQGQVFNPLEALA-LFVACLCHDLDHRGK 80 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N F+VN++S LA +Y+ S +E+HH + +LQNDG Sbjct: 81 NNAFMVNTASPLASVYS-TSTMEHHHFNMTITILQNDG 117 >UniRef50_A2ERL4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=2; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1180 Score = 74.9 bits (176), Expect = 2e-12 Identities = 31/87 (35%), Positives = 52/87 (59%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA DVTQ + L VFT E+ + + AA HD +H G TN + V + + Sbjct: 811 PYHNWRHAVDVTQFVTYQIMISGLEKVFTKFELFSLVVAAICHDANHDGFTNIYNVKAET 870 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L ++Y ++SV+E HH ++A +++ ++ Sbjct: 871 PLGILYKNQSVMETHHCSIAIQIMSHE 897 >UniRef50_A0EF18 Cluster: Chromosome undetermined scaffold_92, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_92, whole genome shotgun sequence - Paramecium tetraurelia Length = 929 Score = 74.9 bits (176), Expect = 2e-12 Identities = 41/104 (39%), Positives = 57/104 (54%), Gaps = 4/104 (3%) Frame = +3 Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNT----PALNAVFTPLEVCAALFAA 611 FLG Y + R NPFHN H +V S +V++N P +F L + + + Sbjct: 668 FLGELEYRYDK--RRNPFHNYNHGVNVMHSCHVIMNKMINQPQYKVLFDQLTKLSLILSG 725 Query: 612 CVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 HDV H G TN F +N+ SE A+ Y+D++VLE +H A A KLL Sbjct: 726 LCHDVGHTGRTNIFEINNFSEKAIRYHDKNVLEQYHAATALKLL 769 >UniRef50_A4VDP2 Cluster: Cyclic nucleotide phosphodiesterase; n=1; Tetrahymena thermophila SB210|Rep: Cyclic nucleotide phosphodiesterase - Tetrahymena thermophila SB210 Length = 1074 Score = 74.5 bits (175), Expect = 3e-12 Identities = 38/95 (40%), Positives = 55/95 (57%), Gaps = 1/95 (1%) Frame = +3 Query: 465 LKEHYI-RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641 L+E Y R+NPFHN H V ++ N ++ + +F+ HDV H G Sbjct: 773 LREKYNKRENPFHNFDHGIMVMHGCFMIGCRTNANKYLNSIQEFSLVFSGLCHDVSHRGK 832 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 TN F VN+ S+LA+ Y+D+SVLE HH+A FK+L+ Sbjct: 833 TNAFEVNTMSKLAIRYHDQSVLEQHHIAHTFKILR 867 >UniRef50_Q4SV96 Cluster: Chromosome 10 SCAF13771, whole genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 10 SCAF13771, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 816 Score = 69.3 bits (162), Expect(2) = 3e-12 Identities = 33/61 (54%), Positives = 41/61 (67%) Frame = +3 Query: 558 ALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK 737 +L + LE+ A AA +HD DHPG TN FLV +S+ AL+YND SVLENHH A A+ Sbjct: 461 SLAGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQALLYNDRSVLENHHAASAWN 520 Query: 738 L 740 L Sbjct: 521 L 521 Score = 25.0 bits (52), Expect(2) = 3e-12 Identities = 11/29 (37%), Positives = 15/29 (51%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTP 557 E+ R P+HN +HA DV + L P Sbjct: 392 ENGYRVIPYHNRIHATDVLHAVWYLTTQP 420 >UniRef50_O96077 Cluster: EFPDE3; n=1; Ephydatia fluviatilis|Rep: EFPDE3 - Ephydatia fluviatilis Length = 1054 Score = 74.1 bits (174), Expect = 3e-12 Identities = 34/59 (57%), Positives = 42/59 (71%) Frame = +3 Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 + F+ LEV A AA VHD DHPG TN FLV + S LA++YND +VLENHH A ++ LL Sbjct: 661 SAFSILEVFATYMAAAVHDFDHPGRTNAFLVATKSPLAILYNDRAVLENHHCAASWDLL 719 >UniRef50_A7RXZ4 Cluster: Predicted protein; n=3; Eumetazoa|Rep: Predicted protein - Nematostella vectensis Length = 367 Score = 74.1 bits (174), Expect = 3e-12 Identities = 37/65 (56%), Positives = 43/65 (66%) Frame = +3 Query: 558 ALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK 737 AL V LE+ + AA +HD DHPG TN FLV + S AL+YND SVLENHH A AF Sbjct: 149 ALVDVIPLLELLSLYTAAAMHDYDHPGRTNAFLVATLSHQALLYNDRSVLENHHAAAAFT 208 Query: 738 LLQND 752 LL +D Sbjct: 209 LLMSD 213 >UniRef50_A7AR41 Cluster: 3'5'-cyclic nucleotide phosphodiesterase, putative; n=1; Babesia bovis|Rep: 3'5'-cyclic nucleotide phosphodiesterase, putative - Babesia bovis Length = 777 Score = 73.3 bits (172), Expect = 6e-12 Identities = 38/98 (38%), Positives = 52/98 (53%) Frame = +3 Query: 462 YLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641 Y E+ R+ P+HN +H A V Q L + L + L+ + AA HDV HPG Sbjct: 486 YRIENQYRNVPYHNKMHGAMVAQKVLCLASYTGLLEHLSILDEALLMVAALSHDVGHPGR 545 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N F V + +A +YND SVLEN+H A A ++L G Sbjct: 546 NNAFFVRTHHPVAQLYNDTSVLENYHAASALRVLCTPG 583 >UniRef50_Q57ZK5 Cluster: 3', 5'-cyclic nucleotide phosphodiesterase, putative; n=1; Trypanosoma brucei|Rep: 3', 5'-cyclic nucleotide phosphodiesterase, putative - Trypanosoma brucei Length = 909 Score = 72.5 bits (170), Expect = 1e-11 Identities = 40/93 (43%), Positives = 54/93 (58%), Gaps = 1/93 (1%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLN-TPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647 E+ R NPFHN++ AADV Q+ L + T L T +E+ A +FAA DV HPG TN Sbjct: 357 ENNYRPNPFHNAVRAADVVQAVFSLASATKPLMRHVTLVELKALVFAAVALDVRHPGRTN 416 Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 +FLV + L Y LE H+A AF+L++ Sbjct: 417 EFLVRTCDPLCYRYPGPGTLEQMHVATAFQLVE 449 >UniRef50_A2FKH2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1086 Score = 72.5 bits (170), Expect = 1e-11 Identities = 35/118 (29%), Positives = 59/118 (50%) Frame = +3 Query: 399 HITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFT 578 H G + T F + L++ Y + P+HN HA DVTQ L T + + + Sbjct: 780 HHFGVLQIFKVTNEKFFRFLTALRDKY-KKVPYHNWRHAVDVTQFVTYELITSGYDKILS 838 Query: 579 PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 E+ L A HD +H G TN + V + + L +++ ++SV+E HH A+A ++ + Sbjct: 839 SFELYGLLVACLCHDANHDGFTNVYNVKAETPLGILFKNQSVMETHHCAIAIDIISKE 896 >UniRef50_A2ENJ2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1087 Score = 72.5 bits (170), Expect = 1e-11 Identities = 31/87 (35%), Positives = 50/87 (57%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA DVTQ L T + + T ++ A L AA HD +H G TN + V + + Sbjct: 831 PYHNWRHAVDVTQYVTFELETSGIVSKLTKFDIFALLVAAICHDANHDGFTNVYNVKAET 890 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L +++ ++SV+E HH A+A ++ + Sbjct: 891 PLGILFKNQSVMETHHCAMAISVISKE 917 >UniRef50_A2G2M9 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=2; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1136 Score = 72.1 bits (169), Expect = 1e-11 Identities = 37/112 (33%), Positives = 57/112 (50%) Frame = +3 Query: 408 GAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLE 587 G ++ T F L+E Y + P+HN +HA DV Q + + + + T E Sbjct: 828 GLLERFQITNDLFFTFLYRLREAY-NEPPYHNWIHAIDVLQYISYQVRITNSHKILTQFE 886 Query: 588 VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 + A AA HD H GL N F VN+ + L +++ D+SV+E H VA ++L Sbjct: 887 LLAVCVAALCHDAGHQGLNNAFNVNAETPLGILFKDQSVMETFHCTVAIRIL 938 >UniRef50_A2E4B2 Cluster: Response regulator receiver domain containing protein; n=1; Trichomonas vaginalis G3|Rep: Response regulator receiver domain containing protein - Trichomonas vaginalis G3 Length = 637 Score = 72.1 bits (169), Expect = 1e-11 Identities = 36/86 (41%), Positives = 51/86 (59%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NPFHN + Q ++L+ P E A LFAA +HD+ HPG N F + +S Sbjct: 323 NPFHNFRRSIAGLQFATMILSK--YKERVPPFEAAAGLFAALLHDIGHPGTNNMFQIRTS 380 Query: 669 SELALMYNDESVLENHHLAVAFKLLQ 746 S+LAL+YND+SVLE + +V +L+Q Sbjct: 381 SQLALIYNDKSVLEMNSASVGARLVQ 406 >UniRef50_UPI0000D555D7 Cluster: PREDICTED: similar to phosphodiesterase 10A; n=4; Tribolium castaneum|Rep: PREDICTED: similar to phosphodiesterase 10A - Tribolium castaneum Length = 745 Score = 71.3 bits (167), Expect = 2e-11 Identities = 39/92 (42%), Positives = 53/92 (57%) Frame = +3 Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656 + R NP+HN HA +V ++L FT E+ A + AA HDVDHPG TN FL Sbjct: 499 FYRRNPYHNFEHAFNVVHCMYLILKRNIKQ--FTETEIKALMIAALCHDVDHPGFTNNFL 556 Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQND 752 S+++LA +Y + S LENH VA LL ++ Sbjct: 557 ELSNNDLANLY-ENSCLENHQYYVAMLLLDHN 587 >UniRef50_Q4FXD4 Cluster: Putative uncharacterized protein; n=3; Leishmania|Rep: Putative uncharacterized protein - Leishmania major strain Friedlin Length = 1084 Score = 71.3 bits (167), Expect = 2e-11 Identities = 38/88 (43%), Positives = 49/88 (55%), Gaps = 1/88 (1%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLL-NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLV 659 R N +HN +HAADV Q ++ + P L T +E A +FAA VHD+ HPG + FL Sbjct: 607 RANQYHNRVHAADVLQGVYAMICSCPGLLPHMTTVEKRAVVFAAAVHDIRHPGRSEVFLK 666 Query: 660 NSSSELALMYNDESVLENHHLAVAFKLL 743 N+ + YN VLE H A AF LL Sbjct: 667 NTFDATYVHYNGLQVLEQMHTATAFHLL 694 >UniRef50_A5JZK2 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase, putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide phosphodiesterase, putative - Plasmodium vivax Length = 1164 Score = 71.3 bits (167), Expect = 2e-11 Identities = 37/97 (38%), Positives = 59/97 (60%), Gaps = 1/97 (1%) Frame = +3 Query: 459 SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPAL-NAVFTPLEVCAALFAACVHDVDHP 635 S++++ Y + P+HN++HA VTQ L + + + +++ + C HDV HP Sbjct: 860 SFVEKQY-NNVPYHNTIHATMVTQKFFCLSKKLGIYDHMEYKIKLVMFISGIC-HDVGHP 917 Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 G N F VNS L+++YND SVLEN+H ++ FK+LQ Sbjct: 918 GYNNLFFVNSLHPLSIIYNDISVLENYHASITFKILQ 954 >UniRef50_A0E2C5 Cluster: Chromosome undetermined scaffold_74, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_74, whole genome shotgun sequence - Paramecium tetraurelia Length = 975 Score = 71.3 bits (167), Expect = 2e-11 Identities = 42/112 (37%), Positives = 57/112 (50%), Gaps = 3/112 (2%) Frame = +3 Query: 417 DYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLL---NTPALNAVFTPLE 587 D DT FL Y ++ + N FHN H V Q+ + +L + + A+ + Sbjct: 699 DIPLDTLCQFLSEVEY--KYNKKKNVFHNYDHGVSVMQNVHAILLQLHQTSNAAIISTFN 756 Query: 588 VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 A L + HDV H G TN F +NS S LA+ Y+D SVLE HH A + KLL Sbjct: 757 QFALLLSGLCHDVSHTGRTNTFEINSLSNLAIRYHDRSVLEQHHAAKSLKLL 808 >UniRef50_UPI00006CF33D Cluster: 3''''5''''-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3''''5''''-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 354 Score = 70.9 bits (166), Expect = 3e-11 Identities = 41/120 (34%), Positives = 57/120 (47%) Frame = +3 Query: 396 VHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVF 575 + + G + SS+ FL S ++ R NPFHN H V ++ N Sbjct: 64 IDLLGILGQSSNKFQNFLVQLS--NKYDYRGNPFHNFDHGITVAHGIYYIIKQGITNKHL 121 Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 LE + LF+A HDVDH G +N + NS SEL +Y +ES LE HH A ++ G Sbjct: 122 NQLEKFSLLFSALCHDVDHTGHSNAYETNSKSELFTLYGNESPLEKHHYAQTIQIADQCG 181 >UniRef50_Q4T098 Cluster: Chromosome undetermined SCAF11274, whole genome shotgun sequence; n=4; Tetraodontidae|Rep: Chromosome undetermined SCAF11274, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 601 Score = 70.9 bits (166), Expect = 3e-11 Identities = 27/59 (45%), Positives = 43/59 (72%) Frame = +3 Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 T LE+ A +FAA +HD +H G TN F + + S+++L+YND +V ENHH++ ++LLQ + Sbjct: 262 TELEIFATIFAAAIHDYEHTGTTNNFHIQTRSDISLLYNDHAVQENHHVSAVYRLLQTN 320 >UniRef50_Q8IKD3 Cluster: Cyclic nucleotide phosphodiesterase, putative; n=1; Plasmodium falciparum 3D7|Rep: Cyclic nucleotide phosphodiesterase, putative - Plasmodium falciparum (isolate 3D7) Length = 813 Score = 70.9 bits (166), Expect = 3e-11 Identities = 31/86 (36%), Positives = 49/86 (56%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NP+HN+ H A V + L + ++ + L A+ HDV HPG TN +L ++ Sbjct: 454 NPYHNANHGATVCHLSKCLAHITDYDSYLNNTYMICYLIASIAHDVGHPGKTNSYLSETN 513 Query: 669 SELALMYNDESVLENHHLAVAFKLLQ 746 L++ YND S+LEN+H ++ F +LQ Sbjct: 514 HILSIRYNDMSILENYHCSITFSILQ 539 >UniRef50_A2F9J4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1119 Score = 70.9 bits (166), Expect = 3e-11 Identities = 39/97 (40%), Positives = 51/97 (52%) Frame = +3 Query: 453 VCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDH 632 +CS L+ Y P+HN HA DV Q + L LE+ A L AA HDVDH Sbjct: 853 ICS-LRSCY-NVTPYHNWTHACDVMQFVFSCIIRGHLRQYLNDLEIFALLLAAICHDVDH 910 Query: 633 PGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 GL N F + + L ++Y D+ V+E HH A A +LL Sbjct: 911 HGLNNAFHKKARTPLGILYEDKPVMEMHHCATAIRLL 947 >UniRef50_O00408 Cluster: cGMP-dependent 3',5'-cyclic phosphodiesterase; n=47; Eumetazoa|Rep: cGMP-dependent 3',5'-cyclic phosphodiesterase - Homo sapiens (Human) Length = 941 Score = 70.9 bits (166), Expect = 3e-11 Identities = 38/101 (37%), Positives = 52/101 (51%), Gaps = 1/101 (0%) Frame = +3 Query: 456 CSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635 C +K+ Y RD P+HN +HA V+ +L L +E+ A + HD+DH Sbjct: 643 CLMVKKGY-RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHR 701 Query: 636 GLTNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755 G N F V S S LA +Y+ E SV+E HH A A +L G Sbjct: 702 GTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHG 742 >UniRef50_A2E8N2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1103 Score = 70.5 bits (165), Expect = 4e-11 Identities = 33/87 (37%), Positives = 47/87 (54%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA DVTQ L L+ VF+P E+ A L A HD +H G NQ+ + Sbjct: 821 PYHNWTHAVDVTQFMVYQLEKAELSKVFSPFEILAILVATICHDANHNGFNNQYNEKAQL 880 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L +++ D SVLE +H VA ++ + Sbjct: 881 PLGILFKDMSVLEVYHCTVAIGIISKE 907 >UniRef50_A2DG30 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1090 Score = 70.5 bits (165), Expect = 4e-11 Identities = 32/90 (35%), Positives = 51/90 (56%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 R P+HN HA DV Q T ++ L+ +E+ A L AA HD++H G TN + V Sbjct: 774 RPVPYHNWAHAVDVLQFTAYQVHISHLDEKIPKVELFALLVAAICHDLNHDGFTNDYNVK 833 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQND 752 + + L +++ ++SV+E HH V ++ ND Sbjct: 834 AETPLGILFKNQSVMEMHHCEVTIDIMSND 863 >UniRef50_UPI000065CC62 Cluster: cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).; n=1; Takifugu rubripes|Rep: cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A). - Takifugu rubripes Length = 706 Score = 70.1 bits (164), Expect = 5e-11 Identities = 32/63 (50%), Positives = 42/63 (66%) Frame = +3 Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 L+ + LE+ A AA +HD DHPG TN FLV +S+ A++YND SVLENHH A A+ L Sbjct: 378 LSGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNL 437 Query: 741 LQN 749 + Sbjct: 438 FMS 440 >UniRef50_Q4RSB8 Cluster: Chromosome 13 SCAF15000, whole genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 13 SCAF15000, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 737 Score = 70.1 bits (164), Expect = 5e-11 Identities = 32/63 (50%), Positives = 42/63 (66%) Frame = +3 Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 L+ + LE+ A AA +HD DHPG TN FLV +S+ A++YND SVLENHH A A+ L Sbjct: 415 LSGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNL 474 Query: 741 LQN 749 + Sbjct: 475 FMS 477 >UniRef50_Q8I0P7 Cluster: Probable 3',5'-cyclic phosphodiesterase pde-3; n=4; Caenorhabditis|Rep: Probable 3',5'-cyclic phosphodiesterase pde-3 - Caenorhabditis elegans Length = 578 Score = 70.1 bits (164), Expect = 5e-11 Identities = 38/96 (39%), Positives = 51/96 (53%) Frame = +3 Query: 456 CSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635 C YL H +R F V + ++ + + LE+ A AA +HD DHP Sbjct: 268 CYYLSAHPVRST-FLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAMHDYDHP 326 Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 G TN FLV + A++YND SVLENHH A ++KLL Sbjct: 327 GRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLL 362 >UniRef50_A5K353 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase, putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide phosphodiesterase, putative - Plasmodium vivax Length = 803 Score = 69.7 bits (163), Expect = 7e-11 Identities = 31/86 (36%), Positives = 48/86 (55%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NP+HN+ H A V + L + + + L A+ HDV HPG TN +L ++ Sbjct: 433 NPYHNANHGATVCHLSKCLAHITDFDKSLNNTYMICYLIASIAHDVGHPGKTNAYLSETN 492 Query: 669 SELALMYNDESVLENHHLAVAFKLLQ 746 L++ YND S+LEN+H ++ F +LQ Sbjct: 493 HILSIRYNDMSILENYHCSITFSILQ 518 >UniRef50_A2FBN7 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1090 Score = 69.7 bits (163), Expect = 7e-11 Identities = 30/84 (35%), Positives = 47/84 (55%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN +HA DV Q + + L +FT E+ A L AA HD H G N + V + + Sbjct: 831 PYHNWIHAVDVVQYVSYEMRLGELENIFTKFEIFAMLVAAVCHDAGHSGFNNIYNVKAET 890 Query: 672 ELALMYNDESVLENHHLAVAFKLL 743 L +++ ++SV+E +H VA +L Sbjct: 891 PLGILFKEQSVMETYHCTVAISIL 914 >UniRef50_A0E1V7 Cluster: Chromosome undetermined scaffold_74, whole genome shotgun sequence; n=3; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_74, whole genome shotgun sequence - Paramecium tetraurelia Length = 1007 Score = 69.7 bits (163), Expect = 7e-11 Identities = 37/98 (37%), Positives = 55/98 (56%), Gaps = 4/98 (4%) Frame = +3 Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLN--TPALNAVF--TPLEVCAALFAACVHDVDHPG 638 ++ + +NP+HN H V Q+ N + T L+ F + C L A C HDV H G Sbjct: 739 QYNMNNNPYHNFDHGVAVMQAVNCFIKSLTNQLDQQFFNNITKFCLLLSALC-HDVAHTG 797 Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 TN + NS S+LA+ Y+D+ +LE HH A K+L++D Sbjct: 798 KTNAYEANSISQLAIRYHDKVILEQHHAATTIKILRDD 835 >UniRef50_A2EIP4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=2; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1334 Score = 69.3 bits (162), Expect = 9e-11 Identities = 34/95 (35%), Positives = 50/95 (52%), Gaps = 4/95 (4%) Frame = +3 Query: 480 IRDN----PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647 IRDN P+HN HA DV Q + N + + E+ A L A HDV H G TN Sbjct: 1075 IRDNYKKVPYHNWRHAVDVMQFVAYQILVSGCNTILSKFEIFAILVACLCHDVGHDGFTN 1134 Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 F + + L L++ ++SV+E HH +V+ +L + Sbjct: 1135 AFNEKAETPLGLLFKNQSVMETHHCSVSIGILSKE 1169 >UniRef50_Q4N6H0 Cluster: Putative uncharacterized protein; n=1; Theileria parva|Rep: Putative uncharacterized protein - Theileria parva Length = 840 Score = 68.9 bits (161), Expect = 1e-10 Identities = 30/84 (35%), Positives = 48/84 (57%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN +H V Q L N + + + ++ + + HD+ HPGLTN F +NS + Sbjct: 606 YHNQMHGVFVCQKLLCLSNFTNVYSRLSVIDRTILIISGLCHDIGHPGLTNAFFINSGHQ 665 Query: 675 LALMYNDESVLENHHLAVAFKLLQ 746 LA ++ND+SVLEN H + F +L+ Sbjct: 666 LAHLFNDKSVLENFHCCLTFNVLR 689 >UniRef50_A0CZB5 Cluster: Chromosome undetermined scaffold_32, whole genome shotgun sequence; n=4; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_32, whole genome shotgun sequence - Paramecium tetraurelia Length = 1270 Score = 68.9 bits (161), Expect = 1e-10 Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 1/98 (1%) Frame = +3 Query: 459 SYLKEHYIR-DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635 S L++ Y + +N FHN H V QS + +L A + + HDV H Sbjct: 994 SVLQQKYNKKNNSFHNYDHGISVMQSAHFMLQCEKAKQFIDDFRRMATIISGLCHDVSHT 1053 Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 G TN F++NS S+LA Y+D S LE HH A +L++ Sbjct: 1054 GRTNVFMINSQSKLATRYHDSSPLEQHHAATTIFMLKD 1091 >UniRef50_O94034 Cluster: Nucleotide phosphodiesterase; n=4; Saccharomycetales|Rep: Nucleotide phosphodiesterase - Candida albicans (Yeast) Length = 571 Score = 59.7 bits (138), Expect(2) = 1e-10 Identities = 26/60 (43%), Positives = 37/60 (61%) Frame = +3 Query: 549 NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728 N+ A P++ L AA HDV HPG TN F++ S+ AL+YND SVLE++H ++ Sbjct: 326 NSSEEKASLNPIQTLGLLVAALGHDVGHPGTTNDFMIKFSAPTALLYNDRSVLESYHASL 385 Score = 29.1 bits (62), Expect(2) = 1e-10 Identities = 11/23 (47%), Positives = 15/23 (65%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQS 533 +++ Y NPFHN HA DV Q+ Sbjct: 263 VRDTYKNGNPFHNFRHAVDVLQA 285 >UniRef50_A2DF08 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1040 Score = 68.5 bits (160), Expect = 2e-10 Identities = 32/87 (36%), Positives = 48/87 (55%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA DVTQ L + V T EV A L +A HD +H G TN + V + + Sbjct: 785 PYHNWRHAVDVTQFVVYELLESGCDKVLTKFEVFALLVSAVCHDANHDGFTNVYNVKAET 844 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L +++ ++SV+E HH VA ++ + Sbjct: 845 PLGILFKNQSVMETHHCQVAIGVISKE 871 >UniRef50_Q14432 Cluster: cGMP-inhibited 3',5'-cyclic phosphodiesterase A; n=27; Euteleostomi|Rep: cGMP-inhibited 3',5'-cyclic phosphodiesterase A - Homo sapiens (Human) Length = 1141 Score = 68.5 bits (160), Expect = 2e-10 Identities = 31/56 (55%), Positives = 39/56 (69%) Frame = +3 Query: 582 LEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 LE+ A AA +HD DHPG TN FLV +S+ A++YND SVLENHH A A+ L + Sbjct: 824 LELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMS 879 >UniRef50_UPI0000D8B81A Cluster: UPI0000D8B81A related cluster; n=1; Mus musculus|Rep: UPI0000D8B81A UniRef100 entry - Mus musculus Length = 746 Score = 67.7 bits (158), Expect = 3e-10 Identities = 31/87 (35%), Positives = 45/87 (51%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN HA +V Q +L T + T +E+ A + HD+DH G N F S S Sbjct: 495 YHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSA 554 Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755 LA +Y + LE+HH A +LQ++G Sbjct: 555 LAQLYGTSATLEHHHFNHAVMILQSEG 581 >UniRef50_O96076 Cluster: EFPDE2; n=1; Ephydatia fluviatilis|Rep: EFPDE2 - Ephydatia fluviatilis Length = 819 Score = 67.7 bits (158), Expect = 3e-10 Identities = 41/99 (41%), Positives = 56/99 (56%), Gaps = 2/99 (2%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641 +K+ Y RD P+HN +HA V L + + LEV ALF +C+ HD+DH G Sbjct: 554 VKKGY-RDPPYHNWMHAFSVAHFLYALYCCSSKLSCLDDLEV-LALFVSCLCHDIDHRGT 611 Query: 642 TNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755 N F V S+S LA +Y+ E SV+E HHLA +L + G Sbjct: 612 NNAFQVCSNSTLACLYSSEGSVMERHHLAQTLCILNSPG 650 >UniRef50_A2FQ29 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=2; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1175 Score = 67.7 bits (158), Expect = 3e-10 Identities = 27/87 (31%), Positives = 47/87 (54%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN LHA DV Q LL L + + E+ + + HD++H G +N + + + Sbjct: 904 PYHNFLHAVDVMQFAVYLLKKSKLESEISKFEILGLIISCLCHDINHDGFSNSYNEKAQT 963 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L ++Y ++SVLE HH +V ++ + Sbjct: 964 PLGILYKNQSVLETHHCSVCISIMTRE 990 >UniRef50_A2DNV4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1023 Score = 67.7 bits (158), Expect = 3e-10 Identities = 32/107 (29%), Positives = 55/107 (51%) Frame = +3 Query: 432 TGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAA 611 T F + + E Y + P+HN HA DVTQ + ++ + T E+ L A Sbjct: 756 TNEKFFSFLTEVSESYNKV-PYHNRRHAVDVTQFVAYEIIIGKIDKILTKEELFCLLIAC 814 Query: 612 CVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 HD++H G TN + V + + L +++ ++SV+E HH V ++ N+ Sbjct: 815 ICHDINHDGFTNVYNVKAETPLGILFKNQSVMETHHCEVTIGIMTNE 861 >UniRef50_P30645 Cluster: Probable 3',5'-cyclic phosphodiesterase pde-2; n=5; Eumetazoa|Rep: Probable 3',5'-cyclic phosphodiesterase pde-2 - Caenorhabditis elegans Length = 859 Score = 67.3 bits (157), Expect = 4e-10 Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 3/93 (3%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 R P+HN HA VT + L T A+ + +E + L A HD+DH G TN F + Sbjct: 417 RPVPYHNWSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQ 476 Query: 663 S--SSELALMYNDE-SVLENHHLAVAFKLLQND 752 S + L+++Y+ E SVLE HH A KLLQ + Sbjct: 477 SLQKTPLSVLYSTEGSVLERHHFAQTIKLLQQE 509 >UniRef50_Q9HCR9 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; n=42; Eumetazoa|Rep: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) Length = 934 Score = 67.3 bits (157), Expect = 4e-10 Identities = 31/87 (35%), Positives = 45/87 (51%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN HA +V Q +L T + T +E+ A + HD+DH G N F S S Sbjct: 663 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 722 Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755 LA +Y + LE+HH A +LQ++G Sbjct: 723 LAQLYGTSATLEHHHFNHAVMILQSEG 749 >UniRef50_UPI00006A17C5 Cluster: cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).; n=1; Xenopus tropicalis|Rep: cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1). - Xenopus tropicalis Length = 959 Score = 66.9 bits (156), Expect = 5e-10 Identities = 31/60 (51%), Positives = 41/60 (68%) Frame = +3 Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 L++ LE+ A AA +HD DHPG TN FLV +++ A++YND SVLENHH A A+ L Sbjct: 696 LSSNIPALELMALFVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL 755 >UniRef50_Q4SI77 Cluster: Chromosome 5 SCAF14581, whole genome shotgun sequence; n=3; Clupeocephala|Rep: Chromosome 5 SCAF14581, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 750 Score = 66.9 bits (156), Expect = 5e-10 Identities = 30/53 (56%), Positives = 38/53 (71%) Frame = +3 Query: 582 LEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 LE+ A AA +HD DHPG TN FLV +++ A++YND SVLENHH A A+ L Sbjct: 442 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAAAAWSL 494 >UniRef50_Q7QRM3 Cluster: GLP_481_5888_1773; n=1; Giardia lamblia ATCC 50803|Rep: GLP_481_5888_1773 - Giardia lamblia ATCC 50803 Length = 1371 Score = 56.4 bits (130), Expect(2) = 6e-10 Identities = 23/67 (34%), Positives = 41/67 (61%) Frame = +3 Query: 543 LLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHL 722 L+ A+ P++ A LF + HD+ H G+ N F +N+ + LAL+YNDE+ LE+ H Sbjct: 1118 LITEQPRQALIRPVDFLALLFGSLCHDLGHTGIDNLFCINTENALALLYNDEAPLEHAHA 1177 Query: 723 AVAFKLL 743 +++ ++ Sbjct: 1178 TLSWHII 1184 Score = 30.3 bits (65), Expect(2) = 6e-10 Identities = 18/51 (35%), Positives = 24/51 (47%) Frame = +3 Query: 402 ITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNT 554 + G Y S L V L+ Y +HN LHAADV Q + +L+T Sbjct: 1037 LLGITTYFSIHDNVLLAVLIELESSYT-STLYHNKLHAADVAQMSMYMLST 1086 >UniRef50_Q3KVL8 Cluster: High-affinity phosphodiesterase; n=4; Eukaryota|Rep: High-affinity phosphodiesterase - Cryptococcus neoformans var. neoformans Length = 555 Score = 56.8 bits (131), Expect(2) = 6e-10 Identities = 29/68 (42%), Positives = 40/68 (58%) Frame = +3 Query: 552 TPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVA 731 T + P ++ A L AA HDV HPGL+N F+V S L+ +Y D+SVLEN H + Sbjct: 307 TKRAREIMRPQDILAVLIAAMGHDVGHPGLSNAFMV--SCPLSQVYEDKSVLENMHCMLV 364 Query: 732 FKLLQNDG 755 +LL+ G Sbjct: 365 VQLLRKYG 372 Score = 29.9 bits (64), Expect(2) = 6e-10 Identities = 12/24 (50%), Positives = 15/24 (62%) Frame = +3 Query: 477 YIRDNPFHNSLHAADVTQSTNVLL 548 Y NP+HN +HA DV Q+T L Sbjct: 248 YHAPNPYHNYVHALDVLQATYTFL 271 >UniRef50_Q4RHZ1 Cluster: Chromosome 8 SCAF15044, whole genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 8 SCAF15044, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 884 Score = 66.5 bits (155), Expect = 7e-10 Identities = 32/96 (33%), Positives = 53/96 (55%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++++Y R +HN HA +V+Q +++ T + V + EV A + HD+DH G Sbjct: 635 VRKNY-RTVAYHNWRHAFNVSQCMFIMITTASFQDVLSDAEVLALMVGCLCHDLDHRGTN 693 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N F + S LAL+Y + LE+HH A +LQ++ Sbjct: 694 NAFQAKTGSALALLYGTSATLEHHHFNHAVMILQSE 729 >UniRef50_A2EY05 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 922 Score = 66.5 bits (155), Expect = 7e-10 Identities = 35/115 (30%), Positives = 57/115 (49%) Frame = +3 Query: 408 GAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLE 587 G ++ + + FL L+ +Y + P+HN HA DV Q + + + E Sbjct: 644 GILEKFQISSSLFLKFLLKLRRNY-NNPPYHNWTHAIDVLQYVSYEIKLTNSHNHLKSQE 702 Query: 588 VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 + + L AA HDV H G N + +N + +++ D SV+E H A+A K+LQ D Sbjct: 703 LLSVLVAALCHDVGHQGFNNAYNINVKTPFGILFKDTSVMETFHCAMAIKILQED 757 >UniRef50_Q13370 Cluster: cGMP-inhibited 3',5'-cyclic phosphodiesterase B; n=26; Euteleostomi|Rep: cGMP-inhibited 3',5'-cyclic phosphodiesterase B - Homo sapiens (Human) Length = 1112 Score = 66.5 bits (155), Expect = 7e-10 Identities = 31/60 (51%), Positives = 41/60 (68%) Frame = +3 Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 L++ LE+ A AA +HD DHPG TN FLV +++ A++YND SVLENHH A A+ L Sbjct: 802 LSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL 861 >UniRef50_UPI0001554EBF Cluster: PREDICTED: similar to cyclic nucleotide phophodiesterase, partial; n=1; Ornithorhynchus anatinus|Rep: PREDICTED: similar to cyclic nucleotide phophodiesterase, partial - Ornithorhynchus anatinus Length = 340 Score = 66.1 bits (154), Expect = 9e-10 Identities = 30/53 (56%), Positives = 38/53 (71%) Frame = +3 Query: 582 LEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 LE+ A AA +HD DHPG TN FLV +++ A++YND SVLENHH A A+ L Sbjct: 187 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL 239 Score = 39.1 bits (87), Expect = 0.12 Identities = 22/48 (45%), Positives = 27/48 (56%), Gaps = 7/48 (14%) Frame = +3 Query: 582 LEVCAALFAACVHDVDHPGLTNQFLV-------NSSSELALMYNDESV 704 LE+ A AA +HD DHPG TN FLV N+SS L Y+D + Sbjct: 110 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQQNTSSPAYLDYSDSGI 157 >UniRef50_A3FQ29 Cluster: CGMP phosphodiesterase A4; n=2; Cryptosporidium|Rep: CGMP phosphodiesterase A4 - Cryptosporidium parvum Iowa II Length = 997 Score = 66.1 bits (154), Expect = 9e-10 Identities = 36/96 (37%), Positives = 53/96 (55%), Gaps = 2/96 (2%) Frame = +3 Query: 462 YLKEHYIR--DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635 + +E IR +N +HN LH +V L L + +E A++ A+ HDV H Sbjct: 711 FFRELNIRYLNNKYHNELHGTNVCHLAICLSRATGLWSHLDTVERLASVIASLGHDVGHI 770 Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 G T+ FLVNS LA+ YND SVLE H ++ F+++ Sbjct: 771 GRTSNFLVNSRHMLAINYNDRSVLEMFHASLTFRII 806 >UniRef50_A2DBZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1126 Score = 66.1 bits (154), Expect = 9e-10 Identities = 34/99 (34%), Positives = 51/99 (51%) Frame = +3 Query: 459 SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPG 638 ++ +E+Y + FHN HA D TQ V L + A L A+ +HDV+H G Sbjct: 878 TFTRENYNENLKFHNFEHALDFTQFVFVCLTRNKFGNCMNVDQKAALLCASLLHDVNHDG 937 Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 FL +SS L +Y ES LE HH++ A ++++ G Sbjct: 938 TNTLFLNQTSSYLVDLYGKESTLERHHVSEALRIVEKSG 976 >UniRef50_UPI00015B4531 Cluster: PREDICTED: similar to cyclic GMP stimulated phosphodiesterase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar to cyclic GMP stimulated phosphodiesterase - Nasonia vitripennis Length = 1684 Score = 65.3 bits (152), Expect = 2e-09 Identities = 36/101 (35%), Positives = 53/101 (52%), Gaps = 3/101 (2%) Frame = +3 Query: 462 YLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHP 635 Y+K+ Y RD P+HN +HA V +L+ L + T L+ L + HD+DH Sbjct: 423 YVKKGY-RDAPYHNWMHAFSVAHFAYLLMKNLNLVRDGYMTSLQALVFLVSCLCHDIDHR 481 Query: 636 GLTNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755 G N F + LA +Y+ E SV+E HHLA + +L +G Sbjct: 482 GTNNSFQTKCGTILASLYSSEGSVMERHHLAQSMCILNTEG 522 >UniRef50_Q6S996 Cluster: Class I phosphodiesterase PDEB1; n=21; Trypanosomatidae|Rep: Class I phosphodiesterase PDEB1 - Leishmania major Length = 940 Score = 65.3 bits (152), Expect = 2e-09 Identities = 32/89 (35%), Positives = 50/89 (56%), Gaps = 3/89 (3%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN H DV Q+ + L T + + T LE L A VHD+DH G+ N F + + S Sbjct: 679 PYHNFYHVVDVCQTLHTYLYTGKASELLTELECYVLLVTALVHDLDHMGVNNSFYLKTDS 738 Query: 672 ELALMYN---DESVLENHHLAVAFKLLQN 749 L ++ + + SVLE HH ++A ++L + Sbjct: 739 PLGILSSASGNNSVLEVHHCSLAIEILSD 767 >UniRef50_A2F408 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1086 Score = 65.3 bits (152), Expect = 2e-09 Identities = 28/87 (32%), Positives = 47/87 (54%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA DVTQ + + + +E+ A + AA HD +H G TN F + + Sbjct: 807 PYHNWRHACDVTQFVTYEIILSGAEKILSNMELFALIVAALCHDANHDGFTNVFNEKAET 866 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L +++ ++SV+E HH VA ++ + Sbjct: 867 PLGILFKNQSVMETHHCEVAIGIISKE 893 >UniRef50_A0BZK9 Cluster: Chromosome undetermined scaffold_139, whole genome shotgun sequence; n=3; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_139, whole genome shotgun sequence - Paramecium tetraurelia Length = 987 Score = 65.3 bits (152), Expect = 2e-09 Identities = 35/104 (33%), Positives = 58/104 (55%), Gaps = 7/104 (6%) Frame = +3 Query: 459 SYLKE----HYIRDNPFHNSLHAADVTQSTNVLLNTPALNA---VFTPLEVCAALFAACV 617 S++KE + + +NP+HN H V Q+ + + A + + + ++ Sbjct: 720 SFIKEMEYNYNVNNNPYHNYDHGITVMQTAHYFCSELAQTSKSKIIDNFNRFILMISSFG 779 Query: 618 HDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 HDV H G TN F +NS S+LA+ Y+D+SVLE HH A+ ++L+N Sbjct: 780 HDVGHTGKTNVFEINSLSDLAIRYHDKSVLEQHHAALTIQVLKN 823 >UniRef50_A5DVX9 Cluster: Putative uncharacterized protein; n=1; Lodderomyces elongisporus NRRL YB-4239|Rep: Putative uncharacterized protein - Lodderomyces elongisporus (Yeast) (Saccharomyces elongisporus) Length = 638 Score = 64.9 bits (151), Expect = 2e-09 Identities = 29/61 (47%), Positives = 40/61 (65%) Frame = +3 Query: 546 LNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLA 725 LN L V P++ A L +A HDV HPG TN FL+ + + ++L+YND SVLE++H A Sbjct: 366 LNQGGLGCVINPVQSLALLMSALGHDVGHPGTTNAFLMQNKAPISLIYNDRSVLESYHAA 425 Query: 726 V 728 V Sbjct: 426 V 426 >UniRef50_Q3SBD3 Cluster: Sperm phosphodiesterase 5; n=1; Strongylocentrotus purpuratus|Rep: Sperm phosphodiesterase 5 - Strongylocentrotus purpuratus (Purple sea urchin) Length = 949 Score = 64.5 bits (150), Expect = 3e-09 Identities = 32/87 (36%), Positives = 49/87 (56%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN HA +V Q+ ++ T L + T LE+ A + A HD+DH G N F V +SS Sbjct: 617 YHNWRHAFNVAQTMFSIVMTGKLRKLLTDLEIFALIVACLCHDLDHRGTNNTFQVKTSSP 676 Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755 L+L+Y S +E+HH +L ++G Sbjct: 677 LSLLYG-TSTMEHHHFDHCIMILNSEG 702 >UniRef50_A2E0V4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 438 Score = 64.5 bits (150), Expect = 3e-09 Identities = 28/87 (32%), Positives = 48/87 (55%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA DVTQ + VFT E + A C D +H G TN + + + + Sbjct: 211 PYHNWRHAVDVTQFVTYQIMISGHEKVFTKFEFNLVVAAIC-RDANHDGFTNIYNIKAET 269 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L ++Y ++SV+E HH ++A +++ ++ Sbjct: 270 PLGILYKNQSVMETHHCSIAIQIMSHE 296 >UniRef50_A0D565 Cluster: Chromosome undetermined scaffold_38, whole genome shotgun sequence; n=5; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_38, whole genome shotgun sequence - Paramecium tetraurelia Length = 964 Score = 64.5 bits (150), Expect = 3e-09 Identities = 40/113 (35%), Positives = 54/113 (47%), Gaps = 4/113 (3%) Frame = +3 Query: 417 DYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVL----LNTPALNAVFTPL 584 DY A +C+ ++ R N FHN H V Q T+ + + T + + Sbjct: 688 DYRISQDALCSFLCALEYKYNKRGNQFHNYDHGVTVMQCTHAISLEIMKTQYAHLLNQFT 747 Query: 585 EVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 + L C HDV H G TN F +NS S L + Y+D SVLE HH A + KLL Sbjct: 748 KFVLILSGLC-HDVSHTGRTNIFEINSLSNLTIRYHDRSVLEQHHAATSIKLL 799 >UniRef50_Q4SPD6 Cluster: Chromosome 16 SCAF14537, whole genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 16 SCAF14537, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 560 Score = 64.1 bits (149), Expect = 4e-09 Identities = 27/46 (58%), Positives = 35/46 (76%) Frame = +3 Query: 606 AACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 AA HD+DHPG N + +N+ +ELA+ YND S LENHH AVAF++L Sbjct: 314 AAVCHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQIL 359 >UniRef50_Q17L35 Cluster: Cgmp-dependent 3,5-cyclic phosphodiesterase; n=2; Culicidae|Rep: Cgmp-dependent 3,5-cyclic phosphodiesterase - Aedes aegypti (Yellowfever mosquito) Length = 502 Score = 64.1 bits (149), Expect = 4e-09 Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 3/92 (3%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQ-STNVLLNTPAL-NAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656 RD P+HN HA V + ++++N + N V T ++ + L AA HD+DH G +N + Sbjct: 234 RDTPYHNWWHAFSVAHFAYSLMVNLKLIENGVITKMQGFSFLIAAFCHDLDHRGTSNTYQ 293 Query: 657 VNSSSELALMYNDE-SVLENHHLAVAFKLLQN 749 SSS LA +Y+ E SV E HHL+ A +L + Sbjct: 294 TQSSSPLARLYSSEGSVNERHHLSQAICILND 325 >UniRef50_Q4SVG8 Cluster: Chromosome undetermined SCAF13758, whole genome shotgun sequence; n=4; Tetraodontidae|Rep: Chromosome undetermined SCAF13758, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 928 Score = 63.3 bits (147), Expect = 6e-09 Identities = 33/97 (34%), Positives = 50/97 (51%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 +K++Y + +HN HA + QS LL + L T LEV A + A HD+DH G+ Sbjct: 662 IKKNYRKSVAYHNWRHAFNTAQSMFALLKSGRLQNELTDLEVLALMIATLSHDLDHRGVN 721 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N ++ S LA +Y S +E+HH +L + G Sbjct: 722 NSYIQRSEHPLAQLY-CHSTMEHHHFDHCLMILNSPG 757 >UniRef50_Q9VFI9 Cluster: CG8279-PA; n=8; Endopterygota|Rep: CG8279-PA - Drosophila melanogaster (Fruit fly) Length = 1131 Score = 63.3 bits (147), Expect = 6e-09 Identities = 32/97 (32%), Positives = 51/97 (52%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 ++++Y R +HN HA +V Q+ +L T + T LE+ L A HD+DH G Sbjct: 721 VRKNY-RPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTN 779 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N F + S LA++Y S +E+HH +L ++G Sbjct: 780 NAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEG 815 >UniRef50_UPI0000588CD9 Cluster: PREDICTED: hypothetical protein; n=1; Strongylocentrotus purpuratus|Rep: PREDICTED: hypothetical protein - Strongylocentrotus purpuratus Length = 701 Score = 62.9 bits (146), Expect = 8e-09 Identities = 35/97 (36%), Positives = 52/97 (53%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 +++HY R PFHN HA DV ++L FT E+ A F + HD+DH GLT Sbjct: 432 VRKHY-RLVPFHNFCHAFDVCHCMFMILLHS--EGRFTDEEMYAMFFGSICHDMDHRGLT 488 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N F + L +Y+ S++E+HH A+ +L +G Sbjct: 489 NSFHAKFGTPLGKLYS-SSIMESHHFAMIVSILHREG 524 >UniRef50_Q7Q8G2 Cluster: ENSANGP00000013023; n=2; Diptera|Rep: ENSANGP00000013023 - Anopheles gambiae str. PEST Length = 747 Score = 62.9 bits (146), Expect = 8e-09 Identities = 35/98 (35%), Positives = 56/98 (57%), Gaps = 1/98 (1%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641 +K++Y R+ +HN HA +VTQ +L + +F +E C AL AC+ HD+DH G Sbjct: 487 VKKNY-RNVTYHNWRHAFNVTQMMFAILTSTQWWKIFGEIE-CLALIIACLCHDLDHRGT 544 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N F + +SS LA +Y+ S +E+HH ++ + G Sbjct: 545 NNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMIINSPG 581 >UniRef50_UPI0000F1D4E2 Cluster: PREDICTED: similar to Phosphodiesterase 5A; n=4; Danio rerio|Rep: PREDICTED: similar to Phosphodiesterase 5A - Danio rerio Length = 905 Score = 62.5 bits (145), Expect = 1e-08 Identities = 31/87 (35%), Positives = 47/87 (54%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN HA Q +L T L + + LEV A + A+ HD+DH G+ N ++ S+ Sbjct: 647 YHNWSHALRTAQCMFAMLQTKELKSNLSSLEVLALMIASLSHDLDHRGVNNSYIQRSNQP 706 Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755 LA +Y +S LE+HH + +L N G Sbjct: 707 LAQLYG-QSSLEHHHYDMCLLILNNPG 732 >UniRef50_A2EHB3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=2; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1213 Score = 62.5 bits (145), Expect = 1e-08 Identities = 28/87 (32%), Positives = 45/87 (51%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA D Q ++ L V T E+ L A HD +H G +N + + + Sbjct: 915 PYHNFTHAIDTMQFMAHVIILCGLKDVLTQKEILILLVACICHDANHDGFSNNYNYKAQT 974 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 L++++ +SVLE HH +V+ +L D Sbjct: 975 PLSILFKGQSVLETHHCSVSITILSKD 1001 >UniRef50_O76074 Cluster: cGMP-specific 3',5'-cyclic phosphodiesterase; n=47; Euteleostomi|Rep: cGMP-specific 3',5'-cyclic phosphodiesterase - Homo sapiens (Human) Length = 875 Score = 61.7 bits (143), Expect = 2e-08 Identities = 31/97 (31%), Positives = 50/97 (51%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 +K++Y ++ +HN HA + Q L + T LE+ A L AA HD+DH G+ Sbjct: 602 VKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVN 661 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N ++ S LA +Y S++E+HH +L + G Sbjct: 662 NSYIQRSEHPLAQLY-CHSIMEHHHFDQCLMILNSPG 697 >UniRef50_Q9VJ79 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11; n=9; Eumetazoa|Rep: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 - Drosophila melanogaster (Fruit fly) Length = 1451 Score = 61.7 bits (143), Expect = 2e-08 Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 1/98 (1%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641 +K++Y R+ +HN HA +V Q +L T +F +E C AL C+ HD+DH G Sbjct: 850 VKKNY-RNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIE-CLALIIGCLCHDLDHRGT 907 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N F + +SS LA +Y+ S +E+HH +L + G Sbjct: 908 NNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPG 944 >UniRef50_Q4DUD4 Cluster: CAMP-specific phosphodiesterase, putative; n=2; Trypanosoma|Rep: CAMP-specific phosphodiesterase, putative - Trypanosoma cruzi Length = 654 Score = 61.3 bits (142), Expect = 3e-08 Identities = 32/96 (33%), Positives = 47/96 (48%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 L E+Y ++N +HN+LHAAD Q ++L +FT EV A A HPG++ Sbjct: 171 LFENYSKENAYHNALHAADSVQMLFLILREKPATLIFTENEVILAFLATLSLGFVHPGVS 230 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752 N FL L L+Y D + ++ L LL + Sbjct: 231 NAFLARIDHPLVLVYGDMTTQQSAGLTALLYLLNRE 266 >UniRef50_A7TPP3 Cluster: Putative uncharacterized protein; n=1; Vanderwaltozyma polyspora DSM 70294|Rep: Putative uncharacterized protein - Vanderwaltozyma polyspora DSM 70294 Length = 518 Score = 61.3 bits (142), Expect = 3e-08 Identities = 37/93 (39%), Positives = 49/93 (52%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 L+ Y + N FHN HA DV Q+T L + L + AA HD+ HPG Sbjct: 255 LEASYHQVNKFHNFRHAVDVMQATYQLCDK--LLTKDDHIYKLLLCMAAIGHDIAHPGTN 312 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 N LVN S +AL +++ESVLEN H + +LL Sbjct: 313 NNLLVNYKSSVALHFDNESVLENFHQVLFQQLL 345 >UniRef50_P06776 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase 2; n=2; Saccharomyces cerevisiae|Rep: 3',5'-cyclic-nucleotide phosphodiesterase 2 - Saccharomyces cerevisiae (Baker's yeast) Length = 526 Score = 61.3 bits (142), Expect = 3e-08 Identities = 38/93 (40%), Positives = 49/93 (52%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 L+ Y + N FHN HA DV Q+T L T L P++ AA HDV HPG Sbjct: 254 LESSYHQVNKFHNFRHAIDVMQATWRLC-TYLLKD--NPVQTLLLCMAAIGHDVGHPGTN 310 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 NQ L N SE+A + + S+LEN H + +LL Sbjct: 311 NQLLCNCESEVAQNFKNVSILENFHRELFQQLL 343 >UniRef50_Q95Z92 Cluster: Possible phosphodiesterase; n=2; Leishmania|Rep: Possible phosphodiesterase - Leishmania major Length = 725 Score = 60.9 bits (141), Expect = 3e-08 Identities = 30/89 (33%), Positives = 45/89 (50%) Frame = +3 Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656 Y DN +HN+ HAAD Q ++ P +N +F+ E+ A DV HPG ++ L Sbjct: 194 YPLDNSYHNATHAADALQMMSLFFREPTVNFLFSDEEIAICFLAVLAVDVAHPGASDTLL 253 Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLL 743 V LA ++ D ++ E+ L V LL Sbjct: 254 VALDHPLASVFGDVAITEHASLLVLTSLL 282 >UniRef50_Q6FM93 Cluster: Similar to sp|P06776 Saccharomyces cerevisiae YOR360c PDE2 high affinity 3; n=1; Candida glabrata|Rep: Similar to sp|P06776 Saccharomyces cerevisiae YOR360c PDE2 high affinity 3 - Candida glabrata (Yeast) (Torulopsis glabrata) Length = 575 Score = 60.9 bits (141), Expect = 3e-08 Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQST-NVLLNTPALNAV-FTPLEVCAALFAACVHDVDHPG 638 ++ Y + N FHN HA DV Q+T + N ++ +PL V +A HD+ HPG Sbjct: 243 IEASYHQINKFHNFRHAVDVMQATWQICSNLGGNGSIDLSPLTVLLLSMSAIGHDIGHPG 302 Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 NQ L S LA ++++SVLEN H + LL Sbjct: 303 TNNQLLCQHESFLATNFDNKSVLENFHNTLFQNLL 337 >UniRef50_P16499 Cluster: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; n=90; Vertebrata|Rep: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha - Homo sapiens (Human) Length = 860 Score = 60.5 bits (140), Expect = 4e-08 Identities = 33/86 (38%), Positives = 47/86 (54%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN H +V Q+ LL T L FT LE A + AA HD+DH G N + + S + Sbjct: 558 YHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNP 617 Query: 675 LALMYNDESVLENHHLAVAFKLLQND 752 LA ++ S+LE HHL LL+++ Sbjct: 618 LAKLHG-SSILERHHLEFGKTLLRDE 642 >UniRef50_Q7YYN8 Cluster: Phosphdiesterase, possible; n=2; Cryptosporidium|Rep: Phosphdiesterase, possible - Cryptosporidium parvum Length = 1001 Score = 59.7 bits (138), Expect = 8e-08 Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 24/122 (19%) Frame = +3 Query: 459 SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPG 638 S L ++Y +NPFHN HA ++ + N L+ P++ LE + ++ HD+DHPG Sbjct: 711 SELIKYYHEENPFHNFHHAVSISITLNNWLDKPSVRHYVNSLEAYCLIISSLSHDLDHPG 770 Query: 639 LTN------------------------QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 LTN + L N++ +YN+ SVLENHH ++ F +L Sbjct: 771 LTNDMIKELNILSRKVLQEFTTDEQFFEILQNNTLSTLKIYNNFSVLENHHSSLLFVILN 830 Query: 747 ND 752 ++ Sbjct: 831 DE 832 >UniRef50_A3FPW6 Cluster: Phosphdiesterase, putative; n=1; Cryptosporidium parvum Iowa II|Rep: Phosphdiesterase, putative - Cryptosporidium parvum Iowa II Length = 1206 Score = 59.7 bits (138), Expect = 8e-08 Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 24/122 (19%) Frame = +3 Query: 459 SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPG 638 S L ++Y +NPFHN HA ++ + N L+ P++ LE + ++ HD+DHPG Sbjct: 916 SELIKYYHEENPFHNFHHAVSISITLNNWLDKPSVRHYVNSLEAYCLIISSLSHDLDHPG 975 Query: 639 LTN------------------------QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 LTN + L N++ +YN+ SVLENHH ++ F +L Sbjct: 976 LTNDMIKELNILSRKVLQEFTTDEQFFEILQNNTLSTLKIYNNFSVLENHHSSLLFVILN 1035 Query: 747 ND 752 ++ Sbjct: 1036 DE 1037 >UniRef50_A2FQB0 Cluster: GAF domain containing protein; n=1; Trichomonas vaginalis G3|Rep: GAF domain containing protein - Trichomonas vaginalis G3 Length = 1042 Score = 59.7 bits (138), Expect = 8e-08 Identities = 28/88 (31%), Positives = 48/88 (54%) Frame = +3 Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665 D P+HN HA DV Q + +L + +F P+E+ A AA HD H G +N F + Sbjct: 797 DVPYHNWRHACDVVQFVSFVLQSINAKEIFEPIEISAIFIAAICHDAGHDGYSNIFNRQA 856 Query: 666 SSELALMYNDESVLENHHLAVAFKLLQN 749 S+ L +Y+ ++ E HL++ +++ + Sbjct: 857 STPLGQIYSGKNCEELFHLSLIARVVNS 884 >UniRef50_Q16HU8 Cluster: Camp and camp-inhibited cgmp 3,5-cyclic phosphodiesterase; n=5; Eumetazoa|Rep: Camp and camp-inhibited cgmp 3,5-cyclic phosphodiesterase - Aedes aegypti (Yellowfever mosquito) Length = 767 Score = 59.3 bits (137), Expect = 1e-07 Identities = 33/98 (33%), Positives = 54/98 (55%), Gaps = 1/98 (1%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQST-NVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641 +K++Y R P+HN H V + +++ N P VF P E A + HD+DH G Sbjct: 505 VKKNY-RRVPYHNWTHGFSVANTMYSIIKNCPH---VFRPNECLALFIGSLCHDLDHRGK 560 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N+F++++ S LA +Y+ S +E+HH +LQ +G Sbjct: 561 NNKFMLDTESPLAAIYS-TSTMEHHHFNQTVTILQQEG 597 >UniRef50_UPI000023CCA1 Cluster: hypothetical protein FG06914.1; n=1; Gibberella zeae PH-1|Rep: hypothetical protein FG06914.1 - Gibberella zeae PH-1 Length = 886 Score = 58.8 bits (136), Expect = 1e-07 Identities = 27/60 (45%), Positives = 37/60 (61%) Frame = +3 Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 ++ TP E L A HDV HPG+ N FLV ++ LA +YND SVLE+ H A ++L+ Sbjct: 355 SLITPFEALTLLITAIGHDVGHPGVNNGFLVTLNAPLAQLYNDRSVLESFHCAAYSQILR 414 >UniRef50_A2DM77 Cluster: GAF domain containing protein; n=1; Trichomonas vaginalis G3|Rep: GAF domain containing protein - Trichomonas vaginalis G3 Length = 1072 Score = 58.8 bits (136), Expect = 1e-07 Identities = 28/88 (31%), Positives = 45/88 (51%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 PFHN A D Q N+L+N L + P E A + A HD+ H G+ N++L ++S Sbjct: 820 PFHNFYLAIDQLQFLNILINEGNLERILQPTEFLALIIATLCHDMGHDGVDNKYLRETNS 879 Query: 672 ELALMYNDESVLENHHLAVAFKLLQNDG 755 + + E ENHH + ++++ G Sbjct: 880 PIFAAF-PEYPNENHHFVILIEVIKRSG 906 >UniRef50_Q1DXU2 Cluster: Putative uncharacterized protein; n=1; Coccidioides immitis|Rep: Putative uncharacterized protein - Coccidioides immitis Length = 900 Score = 58.8 bits (136), Expect = 1e-07 Identities = 26/62 (41%), Positives = 39/62 (62%) Frame = +3 Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740 ++++ TP + L A HDV HPG+ N FLV ++ LA +YND+SVLE H A ++ Sbjct: 403 MSSILTPFDALTLLITAIGHDVGHPGVNNVFLVKLNAPLAQLYNDKSVLEAFHCAAYSQI 462 Query: 741 LQ 746 L+ Sbjct: 463 LR 464 >UniRef50_Q4DJ46 Cluster: Putative uncharacterized protein; n=2; Trypanosoma cruzi|Rep: Putative uncharacterized protein - Trypanosoma cruzi Length = 754 Score = 58.4 bits (135), Expect = 2e-07 Identities = 30/85 (35%), Positives = 47/85 (55%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NPFHN+ HA+D+ + N L+ P + F+ E+ + LFA+ V + H G+TN FL+ Sbjct: 370 NPFHNAYHASDIVLAANQFLSEPHVAENFSDEELFSFLFASTVMKLGHVGMTNAFLIKIH 429 Query: 669 SELALMYNDESVLENHHLAVAFKLL 743 A +Y S ++ LA+ LL Sbjct: 430 HPYAALYGFFSPQQSVSLALGLTLL 454 >UniRef50_Q4SVG0 Cluster: Chromosome 1 SCAF13759, whole genome shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 1 SCAF13759, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 954 Score = 58.0 bits (134), Expect = 2e-07 Identities = 31/86 (36%), Positives = 46/86 (53%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN H +V Q+ LL T L +T LE A + A HD+DH G N + + S + Sbjct: 634 YHNWRHGFNVGQTMFTLLMTGDLKRYYTDLECMAMVTAGFCHDIDHRGTNNLYQMKSGNP 693 Query: 675 LALMYNDESVLENHHLAVAFKLLQND 752 LA ++ S+LE HHL LL+++ Sbjct: 694 LAKLHG-SSILERHHLEFGKTLLRDE 718 >UniRef50_A4RPY9 Cluster: Putative uncharacterized protein; n=1; Magnaporthe grisea|Rep: Putative uncharacterized protein - Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) Length = 862 Score = 58.0 bits (134), Expect = 2e-07 Identities = 42/129 (32%), Positives = 60/129 (46%), Gaps = 21/129 (16%) Frame = +3 Query: 423 SSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQST-NVLLN---------------- 551 S+D + FL C +++ P+HN H DV Q+T N L+ Sbjct: 343 STDQLSTFLIACRAAYNNFV---PYHNFRHVIDVLQATFNFLVQIGSLPPFPPRSDDYIA 399 Query: 552 ----TPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHH 719 T + + P E L A HDV HPG+ N FLV ++ LA +YND SVLE+ H Sbjct: 400 TPQPTSPIATLMKPFEALTLLVTAVGHDVGHPGVNNGFLVTLNAPLAQLYNDRSVLESFH 459 Query: 720 LAVAFKLLQ 746 A ++L+ Sbjct: 460 CAAYSQILR 468 >UniRef50_A2FK96 Cluster: GAF domain containing protein; n=3; Trichomonas vaginalis G3|Rep: GAF domain containing protein - Trichomonas vaginalis G3 Length = 1174 Score = 57.6 bits (133), Expect = 3e-07 Identities = 30/84 (35%), Positives = 45/84 (53%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 PFHN HA DVTQ +++ L + FT LE+ A L +A HD+ H G + Sbjct: 931 PFHNFNHAVDVTQMAYMIVKVGRLFSNFTKLEILALLVSAICHDMGHRGKMGT-SSKVQT 989 Query: 672 ELALMYNDESVLENHHLAVAFKLL 743 L+L++ D+ V+E H + A K + Sbjct: 990 PLSLLFKDQPVMETFHCSSAIKTI 1013 >UniRef50_A2DM90 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=2; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 457 Score = 57.6 bits (133), Expect = 3e-07 Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 1/94 (1%) Frame = +3 Query: 468 KEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647 + HY + P+HN HA D TQ L+ P + + PL+ A L + HD++H G TN Sbjct: 203 QSHY-NNVPYHNWRHATDATQFVFYLITMPHVEEMLPPLDRFALLLSVICHDLEHNGHTN 261 Query: 648 QFLVNSSSELALMYN-DESVLENHHLAVAFKLLQ 746 + +SE + D LENHH +A L+Q Sbjct: 262 DYHRKVNSEFSQEAGPDLPPLENHHQKLAKVLIQ 295 >UniRef50_Q9Y233 Cluster: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; n=44; Euteleostomi|Rep: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A - Homo sapiens (Human) Length = 779 Score = 57.2 bits (132), Expect = 4e-07 Identities = 33/97 (34%), Positives = 49/97 (50%) Frame = +3 Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644 +K++Y R P+HN HA V +L + +FT LE L A HD+DH G + Sbjct: 505 VKKNY-RRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFS 561 Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755 N +L LA +Y+ S +E HH + +LQ +G Sbjct: 562 NSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEG 597 >UniRef50_Q6BSL2 Cluster: Similar to tr|O94034 Candida albicans Nucleotide phosphodiesterase; n=2; Saccharomycetaceae|Rep: Similar to tr|O94034 Candida albicans Nucleotide phosphodiesterase - Debaryomyces hansenii (Yeast) (Torulaspora hansenii) Length = 611 Score = 56.8 bits (131), Expect = 5e-07 Identities = 25/55 (45%), Positives = 37/55 (67%) Frame = +3 Query: 564 NAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728 +A ++ A L AA HDV HPG+TN F++ S+ ++L+YN+ SVLE +H AV Sbjct: 376 SAHMNSIQTLALLIAALGHDVGHPGVTNAFMIKHSAPMSLIYNERSVLELYHSAV 430 >UniRef50_A1D4A4 Cluster: High affinity cAMP phosphodiesterase, putative; n=8; Trichocomaceae|Rep: High affinity cAMP phosphodiesterase, putative - Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181)) Length = 1009 Score = 56.8 bits (131), Expect = 5e-07 Identities = 26/63 (41%), Positives = 39/63 (61%) Frame = +3 Query: 558 ALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK 737 ++ ++ TP + L +A HDV HPG+ N FLV ++ LA +YND SVLE H A + Sbjct: 401 SIASLLTPFDTLTLLISAIGHDVGHPGVNNFFLVKLNAPLAQLYNDNSVLEAFHCAAFSQ 460 Query: 738 LLQ 746 +L+ Sbjct: 461 ILR 463 >UniRef50_Q2H9G5 Cluster: Putative uncharacterized protein; n=1; Chaetomium globosum|Rep: Putative uncharacterized protein - Chaetomium globosum (Soil fungus) Length = 894 Score = 56.0 bits (129), Expect = 9e-07 Identities = 26/56 (46%), Positives = 34/56 (60%) Frame = +3 Query: 579 PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 P E L A HDV HPG+ N FLV ++ LA +YND SVLE+ H A ++L+ Sbjct: 389 PFEALTLLITAIGHDVGHPGVNNGFLVTLNAPLAQLYNDRSVLESFHCAAYSQILR 444 >UniRef50_Q0V6F8 Cluster: Putative uncharacterized protein; n=1; Phaeosphaeria nodorum|Rep: Putative uncharacterized protein - Phaeosphaeria nodorum (Septoria nodorum) Length = 953 Score = 56.0 bits (129), Expect = 9e-07 Identities = 28/72 (38%), Positives = 43/72 (59%) Frame = +3 Query: 531 STNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLE 710 S+ +L +P + + P + L +A HDV HPG+ N FLV ++ LA +YND SVLE Sbjct: 379 SSGLLPKSP-IAELLKPFDALTLLISAIGHDVGHPGVNNAFLVALNAPLAQLYNDRSVLE 437 Query: 711 NHHLAVAFKLLQ 746 + H A ++L+ Sbjct: 438 SFHCAAYSQILR 449 >UniRef50_UPI0000E46CDB Cluster: PREDICTED: similar to phosphodiesterase 9A; n=1; Strongylocentrotus purpuratus|Rep: PREDICTED: similar to phosphodiesterase 9A - Strongylocentrotus purpuratus Length = 526 Score = 55.6 bits (128), Expect = 1e-06 Identities = 24/41 (58%), Positives = 31/41 (75%) Frame = +3 Query: 624 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 +D PG N + VN+ +ELAL YND S LENHH +VAFK+L+ Sbjct: 238 LDRPGYNNAYHVNAGTELALRYNDISPLENHHCSVAFKILE 278 >UniRef50_A6S8A0 Cluster: Putative uncharacterized protein; n=2; Sclerotiniaceae|Rep: Putative uncharacterized protein - Botryotinia fuckeliana B05.10 Length = 945 Score = 54.8 bits (126), Expect = 2e-06 Identities = 24/56 (42%), Positives = 35/56 (62%) Frame = +3 Query: 579 PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 P + + A HDV HPG+ N FLV+ ++ LA +YND SVLE+ H A ++L+ Sbjct: 425 PFDALTLMITAIGHDVGHPGVNNAFLVHLNAPLAQLYNDRSVLESFHCAAYSQILR 480 >UniRef50_A7SW30 Cluster: Predicted protein; n=2; Nematostella vectensis|Rep: Predicted protein - Nematostella vectensis Length = 600 Score = 54.0 bits (124), Expect = 4e-06 Identities = 30/91 (32%), Positives = 45/91 (49%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662 RD P+HN HA V S +++ N T E + A HDVDH G N F+++ Sbjct: 365 RDIPYHNWCHAFSVAHSLWIVIRD---NKSLTDYEKLSLFIAGICHDVDHRGKNNAFMLH 421 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQNDG 755 + LA +Y S +E HH +L+++G Sbjct: 422 CKTPLANLYT-TSTMEWHHFKQGVFILESEG 451 >UniRef50_A0BZW8 Cluster: Chromosome undetermined scaffold_14, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_14, whole genome shotgun sequence - Paramecium tetraurelia Length = 454 Score = 54.0 bits (124), Expect = 4e-06 Identities = 25/85 (29%), Positives = 44/85 (51%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA ++Q L LE+ +A+ A HD++H G+ N + + S Sbjct: 179 PYHNFTHAFQLSQLLFSCYMKSDLKKFCNQLEIFSAILAGLGHDLNHKGVNNMYKIKKSK 238 Query: 672 ELALMYNDESVLENHHLAVAFKLLQ 746 + ++ ++ +VLEN H A F ++Q Sbjct: 239 KFNVLTSEIAVLENMHCATFFNIIQ 263 >UniRef50_Q6CY30 Cluster: Similar to sp|P06776 Saccharomyces cerevisiae YOR360c PDE2 high affinity 3; n=1; Kluyveromyces lactis|Rep: Similar to sp|P06776 Saccharomyces cerevisiae YOR360c PDE2 high affinity 3 - Kluyveromyces lactis (Yeast) (Candida sphaerica) Length = 516 Score = 54.0 bits (124), Expect = 4e-06 Identities = 33/91 (36%), Positives = 46/91 (50%) Frame = +3 Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656 Y + N FHN HA DV Q+T L + L + + L +C AA HDV HPG N Sbjct: 260 YHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFL-LC---IAAIGHDVAHPGTNNMLF 315 Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQN 749 S ++ Y ++SVLEN H + +L + Sbjct: 316 NKYVSPISKYYKEQSVLENFHADIYLDILSH 346 >UniRef50_UPI00006CD10E Cluster: 3''''5''''-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3''''5''''-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 516 Score = 53.6 bits (123), Expect = 5e-06 Identities = 24/87 (27%), Positives = 44/87 (50%) Frame = +3 Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 P+HN HA ++Q + T + E L + HD++H G+ N + V + Sbjct: 229 PYHNWTHAFQLSQMFFTVYFTSDFKDLIDSFEFFVGLLSGLAHDMNHKGVNNLYKVKRKA 288 Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752 E +L Y +++VLEN H++ F ++ + Sbjct: 289 ENSLRYMEQAVLENMHVSTFFHIISRN 315 >UniRef50_Q7RXW7 Cluster: Putative uncharacterized protein NCU00478.1; n=1; Neurospora crassa|Rep: Putative uncharacterized protein NCU00478.1 - Neurospora crassa Length = 806 Score = 53.6 bits (123), Expect = 5e-06 Identities = 40/112 (35%), Positives = 50/112 (44%), Gaps = 20/112 (17%) Frame = +3 Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQST-------NVLLNTPALNAVFT-------- 578 FL C + Y+ P+HN H DV Q+T L P +N T Sbjct: 291 FLKAC---RAAYMGFVPYHNFRHVVDVLQATFQQLLRIGALPPYPNVNGTHTSPIAESPG 347 Query: 579 -----PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHH 719 P E L A HDV HPG+ N FL+ + + LA +YND SVLEN H Sbjct: 348 TPSIGPEEAFTLLLTAIGHDVLHPGVNNGFLIEARAPLAELYNDRSVLENFH 399 >UniRef50_P91119 Cluster: Probable 3',5'-cyclic phosphodiesterase pde-5; n=3; Caenorhabditis|Rep: Probable 3',5'-cyclic phosphodiesterase pde-5 - Caenorhabditis elegans Length = 710 Score = 53.6 bits (123), Expect = 5e-06 Identities = 31/88 (35%), Positives = 44/88 (50%), Gaps = 1/88 (1%) Frame = +3 Query: 495 FHNSLHAADVTQST-NVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671 +HN H V + L+N+P FT LE A + HD+DH G N ++ S+ Sbjct: 484 YHNWAHGWSVAHAMFATLMNSPD---AFTKLEALALYVSCLCHDLDHRGKNNAYMKTMST 540 Query: 672 ELALMYNDESVLENHHLAVAFKLLQNDG 755 LA +Y+ SV+E HH +LQ DG Sbjct: 541 PLASIYS-TSVMERHHFNQTVTILQQDG 567 >UniRef50_Q758Y3 Cluster: ADR395Cp; n=1; Eremothecium gossypii|Rep: ADR395Cp - Ashbya gossypii (Yeast) (Eremothecium gossypii) Length = 480 Score = 53.2 bits (122), Expect = 7e-06 Identities = 35/94 (37%), Positives = 47/94 (50%) Frame = +3 Query: 462 YLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641 +L+ Y + N F N HA DV Q+T L + L+ + L +C +A HDV HPG Sbjct: 224 HLECSYHQGNKFPNFRHAVDVMQATYQLCDLLKLDPGIS-LTLC---ISAIGHDVAHPGT 279 Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743 N + S +A YN SVLEN H V +L Sbjct: 280 NNALMCKYGSPVAKHYNGVSVLENFHSDVFISIL 313 >UniRef50_A2FSQ8 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1017 Score = 52.0 bits (119), Expect = 2e-05 Identities = 30/106 (28%), Positives = 52/106 (49%) Frame = +3 Query: 429 DTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFA 608 D +++ + S +K H ++ P+HN HA D Q L L F L+ + Sbjct: 778 DDQSFYRFLESCMKSH--KNYPYHNWSHAVDTLQFLYYLYYRANLTKYFDELQKTCLFIS 835 Query: 609 ACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746 A HDV H G ++ + V++ S AL++ +ES +E + +LL+ Sbjct: 836 ALCHDVSHNGFSSYYHVSAQSRTALLFGNESPMEILSFSKTAELLE 881 >UniRef50_A6R1R4 Cluster: Predicted protein; n=1; Ajellomyces capsulatus NAm1|Rep: Predicted protein - Ajellomyces capsulatus NAm1 Length = 839 Score = 51.6 bits (118), Expect = 2e-05 Identities = 24/48 (50%), Positives = 33/48 (68%) Frame = +3 Query: 606 AACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749 +A HDV HPG+ N FLV ++ LA +YND SVLE+ H A +LL++ Sbjct: 295 SAIGHDVGHPGVNNVFLVRLNAPLAQLYNDTSVLESFHCAAYSQLLRS 342 >UniRef50_A2FET3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1135 Score = 51.2 bits (117), Expect = 3e-05 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 1/90 (1%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNA-VFTPLEVCAALFAACVHDVDHPGLTNQFLV 659 ++N +HN HA + Q ++ ++ P++ A + A +HD+ H G +N++ + Sbjct: 887 KNNKYHNWNHAVETVQLCYSIVKRGKMSPRAINPMQTTALILACLLHDICHDGTSNEYHI 946 Query: 660 NSSSELALMYNDESVLENHHLAVAFKLLQN 749 + S L ++ D+ LEN L + +LL++ Sbjct: 947 KAKSSLYHVFGDDCPLENSSLTRSVRLLKS 976 >UniRef50_A2EA57 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 1102 Score = 50.4 bits (115), Expect = 5e-05 Identities = 27/88 (30%), Positives = 42/88 (47%) Frame = +3 Query: 480 IRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLV 659 I PFHN H+ D Q L L P ++ LFA +HDV H G +++ Sbjct: 857 INQKPFHNFRHSVDCLQFVYYTLLKSRLCNKLDPHQIVGLLFATLLHDVSHNGYNDEYHK 916 Query: 660 NSSSELALMYNDESVLENHHLAVAFKLL 743 N+ + L + N+ +E +H VA K++ Sbjct: 917 NNKTHLYFVDNNYP-METYHCKVASKII 943 >UniRef50_Q4RG61 Cluster: Chromosome 2 SCAF15106, whole genome shotgun sequence; n=3; Tetraodontidae|Rep: Chromosome 2 SCAF15106, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 899 Score = 50.0 bits (114), Expect = 6e-05 Identities = 25/86 (29%), Positives = 41/86 (47%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN H +V + LL T L ++ L+ A + AA HD+DH G N + S+ Sbjct: 606 YHNWRHGFNVGHTMFCLLQTGRLRKYYSDLDAFAMVAAAFCHDIDHRGTNNLYQTKRSAH 665 Query: 675 LALMYNDESVLENHHLAVAFKLLQND 752 + S++E HHL + L+ + Sbjct: 666 PLAKLHGTSIMERHHLEYSKTLMAEE 691 >UniRef50_UPI000065E700 Cluster: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C).; n=1; Takifugu rubripes|Rep: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C). - Takifugu rubripes Length = 937 Score = 49.6 bits (113), Expect = 8e-05 Identities = 25/83 (30%), Positives = 40/83 (48%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN H +V + LL T L ++ L+ A + AA HD+DH G N + S+ Sbjct: 640 YHNWRHGFNVGHTMFCLLQTGKLRKYYSDLDAFAMVAAAFCHDIDHRGTNNLYQTKRSAH 699 Query: 675 LALMYNDESVLENHHLAVAFKLL 743 + S++E HHL + L+ Sbjct: 700 PLAKLHGTSIMERHHLEYSKTLM 722 >UniRef50_Q22VA7 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Tetrahymena thermophila SB210|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Tetrahymena thermophila SB210 Length = 624 Score = 49.2 bits (112), Expect = 1e-04 Identities = 23/68 (33%), Positives = 39/68 (57%) Frame = +3 Query: 549 NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728 N+P+ P E A AA HD++H GL N + V +++ ++ Y + VLEN H + Sbjct: 333 NSPSWRDYILPFEFFCAQIAALGHDLNHKGLGNLYKVKRNAQCSINYCELGVLENMHASK 392 Query: 729 AFKLLQND 752 F++LQ++ Sbjct: 393 LFQILQSN 400 >UniRef50_A2GFY4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase family protein; n=1; Trichomonas vaginalis G3|Rep: 3'5'-cyclic nucleotide phosphodiesterase family protein - Trichomonas vaginalis G3 Length = 457 Score = 48.0 bits (109), Expect = 3e-04 Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 1/90 (1%) Frame = +3 Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665 D P+HN HA D Q L + P++ + + AA HDV H G +N F Sbjct: 208 DVPYHNWRHACDACQFVYFALLQKPIEHFIQPIDYFSLMTAAICHDVGHNGRSNDFHRQV 267 Query: 666 SSELAL-MYNDESVLENHHLAVAFKLLQND 752 +S+ A +++ LE HH + + L N+ Sbjct: 268 NSKYAQESGSNQPPLEYHHQKITIEFLSNE 297 >UniRef50_A0D3N1 Cluster: Chromosome undetermined scaffold_36, whole genome shotgun sequence; n=2; Paramecium tetraurelia|Rep: Chromosome undetermined scaffold_36, whole genome shotgun sequence - Paramecium tetraurelia Length = 429 Score = 48.0 bits (109), Expect = 3e-04 Identities = 24/83 (28%), Positives = 43/83 (51%) Frame = +3 Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674 +HN HA + Q + L + ++ AAL A+ HD++H G+ N + V S + Sbjct: 161 YHNFTHAFALFQLLFCVYEKSDLKLFVSKQDIFAALLASLSHDINHKGVNNLYKVKKSKK 220 Query: 675 LALMYNDESVLENHHLAVAFKLL 743 L +++VLE+ H++ F +L Sbjct: 221 LNKNICEQAVLESMHVSTLFNIL 243 >UniRef50_Q4QE95 Cluster: Putative uncharacterized protein; n=3; Leishmania|Rep: Putative uncharacterized protein - Leishmania major Length = 1594 Score = 46.8 bits (106), Expect = 6e-04 Identities = 26/85 (30%), Positives = 39/85 (45%) Frame = +3 Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668 NPFHN +HA DV + + LN + A + E LF A V + H G N+ L Sbjct: 1052 NPFHNPVHAVDVVMAAHQWLNEGSTGAALSDDEAMTFLFTAMVQQLAHTGADNRLLGQLK 1111 Query: 669 SELALMYNDESVLENHHLAVAFKLL 743 A++ + S + +A+ LL Sbjct: 1112 HPYAMLCSYASPQQGATVALVMALL 1136 >UniRef50_UPI0000D56333 Cluster: PREDICTED: similar to cGMP-dependent 3,5-cyclic phosphodiesterase (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE); n=1; Tribolium castaneum|Rep: PREDICTED: similar to cGMP-dependent 3,5-cyclic phosphodiesterase (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) - Tribolium castaneum Length = 666 Score = 44.4 bits (100), Expect = 0.003 Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 3/94 (3%) Frame = +3 Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656 R+ PFHN +H + L L + T LE A HDVD+ + F Sbjct: 469 REVPFHNWMHLFSTAHFAYLCLTHLQLVEDKYITQLEALAYFVTCLCHDVDYRAANSSFQ 528 Query: 657 VNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755 S L +Y+ SV+E H L+ ++L ++G Sbjct: 529 QTPSDGLCTLYSSPGSVMERHRLSQILRILNSEG 562 >UniRef50_UPI000065DEB3 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).; n=1; Takifugu rubripes|Rep: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A). - Takifugu rubripes Length = 937 Score = 31.5 bits (68), Expect(2) = 0.20 Identities = 13/31 (41%), Positives = 20/31 (64%) Frame = +3 Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQNDG 755 + S LAL+Y + LE+HH A +LQ++G Sbjct: 741 TGSALALLYGTSATLEHHHFNHAVMILQSEG 771 Score = 25.8 bits (54), Expect(2) = 0.20 Identities = 12/27 (44%), Positives = 14/27 (51%), Gaps = 1/27 (3%) Frame = +3 Query: 597 ALFAACV-HDVDHPGLTNQFLVNSSSE 674 AL C+ HD+DH G N F SE Sbjct: 689 ALMVGCLCHDLDHRGTNNAFQAKCVSE 715 >UniRef50_A4RH78 Cluster: Putative uncharacterized protein; n=1; Magnaporthe grisea|Rep: Putative uncharacterized protein - Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) Length = 876 Score = 37.5 bits (83), Expect = 0.35 Identities = 21/65 (32%), Positives = 36/65 (55%) Frame = +1 Query: 88 DKQQELDLPSLQVEETSERGAKKKEKPRHGGPATTMSQISGVKRTLTHTNSFTGERVPRY 267 DKQ+ +LP L+VEE++E G ++K + GG +S ++ ++ T S + V + Sbjct: 195 DKQRGTELPDLEVEESTEEGQERKPLVKTGGIIREVSAMASIEDV---TGSGSTHHVVLH 251 Query: 268 GVETP 282 GV P Sbjct: 252 GVHWP 256 >UniRef50_A7CYI8 Cluster: Two component transcriptional regulator, winged helix family; n=1; Opitutaceae bacterium TAV2|Rep: Two component transcriptional regulator, winged helix family - Opitutaceae bacterium TAV2 Length = 338 Score = 36.7 bits (81), Expect = 0.62 Identities = 21/50 (42%), Positives = 23/50 (46%), Gaps = 1/50 (2%) Frame = +2 Query: 584 RSLRCSFRCLRPRCRSPGPHQSIPRQL-QFRTRTNVQRRVSPREPPPCSR 730 RSLR SFR RC S Q +PR+ Q R RR P PC R Sbjct: 10 RSLRASFRAFPRRCPSAQTQQGVPRRARQRRLCPRESRRACRHAPRPCHR 59 >UniRef50_A4RJX0 Cluster: Putative uncharacterized protein; n=2; Sordariomycetes|Rep: Putative uncharacterized protein - Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) Length = 1497 Score = 36.7 bits (81), Expect = 0.62 Identities = 16/59 (27%), Positives = 34/59 (57%) Frame = +2 Query: 11 TRS*ATSQIPASPATRSPSISAPHFWTNNRSLTYHPYKSKKLRNAAPRKRKNHVMADQR 187 ++S +TSQIP TR+P + P +++ P ++KLR +P+K + + ++++ Sbjct: 1278 SKSMSTSQIPTLRITRNPELGRPDLLGRSQTSPTRPTSTQKLRLQSPQKLRERLQSEKK 1336 >UniRef50_A5KSE4 Cluster: Putative uncharacterized protein; n=1; candidate division TM7 genomosp. GTL1|Rep: Putative uncharacterized protein - candidate division TM7 genomosp. GTL1 Length = 353 Score = 35.5 bits (78), Expect = 1.4 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 1 GMLNKELSHFSDSSKSGNQISEYICSTF--LDKQQELDL-PSLQVEETSERGAKKKEKPR 171 G + EL FSD+ S + +E+ T L++ D+ P L +E TS +GA + R Sbjct: 44 GFVTDELMLFSDTPVSTAEATEFATDTAEKLNEFASFDIKPILILEPTSSQGALDLTRYR 103 Query: 172 HGGPATTMSQISGVKRTLTHTNSFTGERVPRYGVETP 282 +GG T ++ + + T+ G VP TP Sbjct: 104 NGGYDTILNVFFATLKRTSITDEKLGTLVPFPEANTP 140 >UniRef50_Q5C091 Cluster: SJCHGC03341 protein; n=1; Schistosoma japonicum|Rep: SJCHGC03341 protein - Schistosoma japonicum (Blood fluke) Length = 177 Score = 35.5 bits (78), Expect = 1.4 Identities = 19/51 (37%), Positives = 23/51 (45%), Gaps = 1/51 (1%) Frame = +1 Query: 226 THTNSFTGERVPRYGVETPHXXXXXXXXXXX-DRWGVDIFRIGDLSCGRPL 375 TH +P +GVETP+ D WG+DIF I LS G L Sbjct: 127 THATDIDEPTLPIHGVETPNDKELEERFCQSLDEWGIDIFEIDRLSNGHAL 177 >UniRef50_Q9TXJ7 Cluster: Sperm specific transcript protein 20; n=2; Caenorhabditis|Rep: Sperm specific transcript protein 20 - Caenorhabditis elegans Length = 231 Score = 34.7 bits (76), Expect = 2.5 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 1/51 (1%) Frame = +1 Query: 91 KQQELDLPSLQVEETSERGAKKKEKPRHGGPATTMSQISGVK-RTLTHTNS 240 ++ L+LP L ++T + G KKEKP+ P+T+MS I K R + +NS Sbjct: 123 RKTALNLPCLD-KKTKKAGDAKKEKPKMKAPSTSMSDIEKSKSRAASKSNS 172 >UniRef50_O27572 Cluster: Probable tRNA pseudouridine synthase D; n=3; Methanobacteriaceae|Rep: Probable tRNA pseudouridine synthase D - Methanobacterium thermoautotrophicum Length = 415 Score = 34.7 bits (76), Expect = 2.5 Identities = 16/44 (36%), Positives = 25/44 (56%) Frame = -2 Query: 563 KRRCIQQYVCRLCDIGSVERVVERIVSNIVLLKVTANAKKVRAG 432 KR +Q++C S + +E + N+ L+VTAN KK+R G Sbjct: 79 KRAVTRQWICVSNTAPSEVKAIEERIRNVKFLRVTANEKKLRMG 122 >UniRef50_UPI00006CB312 Cluster: hypothetical protein TTHERM_00456820; n=1; Tetrahymena thermophila SB210|Rep: hypothetical protein TTHERM_00456820 - Tetrahymena thermophila SB210 Length = 842 Score = 34.3 bits (75), Expect = 3.3 Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 4/85 (4%) Frame = +1 Query: 10 NKELSHFSDSSKSGNQISEYICSTFL-DKQQELDLPSLQVEETSERGAKKKEKPRHGGPA 186 N +LS++ + NQI + I + + Q +LD+ S +++ S + K +K GP Sbjct: 274 NNDLSNYEFDDANMNQIQQNIQKIDISNSQDQLDIGSSRIDNNSPQSEKDVDKQNQNGPL 333 Query: 187 TTMSQ---ISGVKRTLTHTNSFTGE 252 S SG + +N+F E Sbjct: 334 NFKSSNDYKSGSNTAVVSSNNFNNE 358 >UniRef50_A6R697 Cluster: Predicted protein; n=1; Ajellomyces capsulatus NAm1|Rep: Predicted protein - Ajellomyces capsulatus NAm1 Length = 281 Score = 33.9 bits (74), Expect = 4.4 Identities = 25/73 (34%), Positives = 35/73 (47%), Gaps = 4/73 (5%) Frame = +3 Query: 495 FHNSLHAADVTQST--NVLLNTPALNAVFTPLEVCAALFAACVH--DVDHPGLTNQFLVN 662 +H+S +A T++ NVL +P +FTPLE L A+ VH + PG N Sbjct: 206 YHSSTSSARTTEALLHNVLAISPVTCIIFTPLEGHRYLMASSVHLLEAALPGNYQMGKQN 265 Query: 663 SSSELALMYNDES 701 SE + YN S Sbjct: 266 FRSESFVAYNKNS 278 >UniRef50_Q5N7R3 Cluster: Putative uncharacterized protein P0034C09.31; n=1; Oryza sativa (japonica cultivar-group)|Rep: Putative uncharacterized protein P0034C09.31 - Oryza sativa subsp. japonica (Rice) Length = 204 Score = 33.5 bits (73), Expect = 5.8 Identities = 17/47 (36%), Positives = 24/47 (51%) Frame = +2 Query: 581 TRSLRCSFRCLRPRCRSPGPHQSIPRQLQFRTRTNVQRRVSPREPPP 721 T ++ C R CR P P S+P Q + R + ++ SPR PPP Sbjct: 121 TEAVAARLGCCRVPCRHPHPPPSVPAQ-RGRCSSWLRSSPSPRPPPP 166 >UniRef50_Q94241 Cluster: Putative uncharacterized protein; n=2; Caenorhabditis|Rep: Putative uncharacterized protein - Caenorhabditis elegans Length = 214 Score = 33.5 bits (73), Expect = 5.8 Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 5/120 (4%) Frame = +3 Query: 411 AVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVL--LNTPALNAVFTPL 584 A Y SD G FL S E +R P+H + Q+ N A+N V L Sbjct: 84 AFQYLSDIGQEFLNENSSRIEQVVR--PYHFLEFDKYIQQAKQRYGDTNKHAMNTVSNEL 141 Query: 585 EVCAALFAACVHDVDHPGLTNQFLVNSSSELALM---YNDESVLENHHLAVAFKLLQNDG 755 + + + DV H G L N +SEL+ M Y D++ N + FK+ + G Sbjct: 142 QDVTRIMVTNIEDVIHRGEALNILENRASELSGMSKKYRDDAKALNRRSTI-FKVAASIG 200 >UniRef50_A2FIR1 Cluster: Putative uncharacterized protein; n=1; Trichomonas vaginalis G3|Rep: Putative uncharacterized protein - Trichomonas vaginalis G3 Length = 500 Score = 33.5 bits (73), Expect = 5.8 Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 2/74 (2%) Frame = +1 Query: 13 KELSHFSDSSKSGNQISEYICSTFLDK--QQELDLPSLQVEETSERGAKKKEKPRHGGPA 186 K SH SD S I S++ D + E + +++E S+ G+K KEK + + Sbjct: 178 KPKSHTSDKKLKPKHHSRQISSSYSDSISEDEYEPSESEIDEISDSGSKPKEKRSNSSKS 237 Query: 187 TTMSQISGVKRTLT 228 + SG ++ L+ Sbjct: 238 KEKTSKSGKEKNLS 251 >UniRef50_Q7SDI5 Cluster: Predicted protein; n=2; Sordariales|Rep: Predicted protein - Neurospora crassa Length = 611 Score = 33.5 bits (73), Expect = 5.8 Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 6/70 (8%) Frame = +2 Query: 329 EWIYSASVIC----HAVDHSLLSRTQRSHHGSC*LLFRYRRVLSWRLQLP*GALY--SRQ 490 +W+Y+ S + DHSL+SR H + LL R +SW + +P G+ + + + Sbjct: 100 KWLYTHSPVLPFLSRPYDHSLVSRADLPDHPAPILLTDSRGRISWTVSIPQGSEFPLTAE 159 Query: 491 SFPQLSPRCR 520 F + +CR Sbjct: 160 DFTNVCEKCR 169 >UniRef50_Q4WB96 Cluster: Pectin methylesterase, putative; n=1; Aspergillus fumigatus|Rep: Pectin methylesterase, putative - Aspergillus fumigatus (Sartorya fumigata) Length = 1764 Score = 31.1 bits (67), Expect(2) = 5.9 Identities = 16/51 (31%), Positives = 27/51 (52%) Frame = +1 Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRSTIFETILSTTLSTL 516 G +T YT T+ +T+++PA T + VT ++T T L + ST+ Sbjct: 1560 GAAVTITDYTTLTTTAKTSTVKLPASTDIITVVTTKTTGKTTTLPASTSTI 1610 Score = 21.0 bits (42), Expect(2) = 5.9 Identities = 9/20 (45%), Positives = 13/20 (65%) Frame = +1 Query: 604 SLPASTMSITRASPINSSST 663 +LPAST +IT S + +T Sbjct: 1602 TLPASTSTITVLSTVTKGTT 1621 >UniRef50_A0VET3 Cluster: Conserved repeat domain precursor; n=1; Delftia acidovorans SPH-1|Rep: Conserved repeat domain precursor - Delftia acidovorans SPH-1 Length = 1396 Score = 33.1 bits (72), Expect = 7.6 Identities = 21/68 (30%), Positives = 35/68 (51%) Frame = +1 Query: 328 GVDIFRIGDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRSTIFETILSTTL 507 G + IG S +V+ + TSR++ T +PA +AF TL ++ T+ +TT Sbjct: 1311 GSGVANIGVFSVTGGTASVSVLSATSRQITLTSALPAGATIAFRTTLSISVAFTLNATT- 1369 Query: 508 STLPMSHS 531 TLP ++ Sbjct: 1370 -TLPNGYA 1376 Database: uniref50 Posted date: Oct 5, 2007 11:19 AM Number of letters in database: 575,637,011 Number of sequences in database: 1,657,284 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.279 0.0580 0.190 Matrix: BLOSUM62 Gap Penalties: Existence: 9, Extension: 2 Number of Hits to DB: 777,192,706 Number of Sequences: 1657284 Number of extensions: 16199023 Number of successful extensions: 53081 Number of sequences better than 10.0: 211 Number of HSP's better than 10.0 without gapping: 50290 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 52965 length of database: 575,637,011 effective HSP length: 99 effective length of database: 411,565,895 effective search space used: 62558016040 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 37 (14.9 bits) X3: 62 (25.0 bits) S1: 41 (21.7 bits)
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