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Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= brS-0170
         (756 letters)

Database: uniref50 
           1,657,284 sequences; 575,637,011 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q9W4T4 Cluster: cAMP-specific 3',5'-cyclic phosphodiest...   194   2e-48
UniRef50_Q13945 Cluster: 3',5'-cyclic AMP phosphodiesterase; n=3...   159   5e-38
UniRef50_P27815 Cluster: cAMP-specific 3',5'-cyclic phosphodiest...   158   1e-37
UniRef50_UPI000065D378 Cluster: cAMP-specific 3',5'-cyclic phosp...   158   2e-37
UniRef50_Q4SP32 Cluster: Chromosome 15 SCAF14542, whole genome s...   158   2e-37
UniRef50_Q3UEI1-2 Cluster: Isoform 2 of Q3UEI1 ; n=1; Mus muscul...   149   7e-35
UniRef50_Q22000 Cluster: Probable 3',5'-cyclic phosphodiesterase...   144   3e-33
UniRef50_O96078 Cluster: EFPDE4; n=1; Ephydatia fluviatilis|Rep:...   127   3e-28
UniRef50_A7SVX8 Cluster: Predicted protein; n=1; Nematostella ve...   113   4e-24
UniRef50_O43862 Cluster: 3'5' cyclic nucleotide phosphodiesteras...   111   2e-23
UniRef50_O43851 Cluster: PDE4C-delta109; n=18; Bilateria|Rep: PD...   105   9e-22
UniRef50_Q9N2V9 Cluster: Probable 3',5'-cyclic phosphodiesterase...   104   3e-21
UniRef50_UPI0000D56A7E Cluster: PREDICTED: similar to High-affin...   103   6e-21
UniRef50_UPI0000519BD4 Cluster: PREDICTED: similar to phosphodie...   103   6e-21
UniRef50_A7SGA1 Cluster: Predicted protein; n=1; Nematostella ve...   103   6e-21
UniRef50_Q14123 Cluster: Calcium/calmodulin-dependent 3',5'-cycl...   102   8e-21
UniRef50_O95263 Cluster: High affinity cAMP-specific and IBMX-in...   102   1e-20
UniRef50_Q8CFW8 Cluster: Phosphodiesterase 8B; n=13; Euteleostom...   100   3e-20
UniRef50_UPI0000DB7125 Cluster: PREDICTED: similar to Phosphodie...   100   4e-20
UniRef50_O18696 Cluster: Probable 3',5'-cyclic phosphodiesterase...   100   4e-20
UniRef50_UPI0000DB6B8B Cluster: PREDICTED: similar to phosphodie...   100   8e-20
UniRef50_Q005X2 Cluster: Phosphodiesterase 1; n=1; Strongylocent...   100   8e-20
UniRef50_Q8SXR0 Cluster: RE69157p; n=9; Coelomata|Rep: RE69157p ...    99   1e-19
UniRef50_UPI0000E7FF0E Cluster: PREDICTED: similar to cAMP phosp...    98   2e-19
UniRef50_Q6NNF2 Cluster: SD02170p; n=9; Diptera|Rep: SD02170p - ...    98   2e-19
UniRef50_Q16J23 Cluster: Camp-specific 3,5-cyclic phosphodiester...    97   3e-19
UniRef50_O96075 Cluster: EFPDE1; n=1; Ephydatia fluviatilis|Rep:...    97   5e-19
UniRef50_Q13946 Cluster: High affinity cAMP-specific 3',5'-cycli...    96   7e-19
UniRef50_UPI00015B4893 Cluster: PREDICTED: similar to camp-speci...    95   1e-18
UniRef50_UPI00015B5210 Cluster: PREDICTED: similar to ENSANGP000...    92   2e-17
UniRef50_A4RV03 Cluster: Predicted protein; n=1; Ostreococcus lu...    92   2e-17
UniRef50_UPI000150A113 Cluster: 3''''5''''-cyclic nucleotide pho...    91   2e-17
UniRef50_Q4N806 Cluster: 3',5' cyclic nucleotide phosphodiestera...    91   2e-17
UniRef50_Q6S998 Cluster: CAMP-specific phosphodiesterase; n=3; L...    91   3e-17
UniRef50_A0EBQ7 Cluster: Chromosome undetermined scaffold_88, wh...    91   3e-17
UniRef50_A0CZ03 Cluster: Chromosome undetermined scaffold_31, wh...    91   4e-17
UniRef50_Q57V52 Cluster: 3', 5'-cyclic nucleotide phosphodiester...    90   6e-17
UniRef50_Q4D500 Cluster: Phosphodiesterase, putative; n=3; Trypa...    90   6e-17
UniRef50_A4HHP3 Cluster: Putative uncharacterized protein; n=3; ...    90   6e-17
UniRef50_Q1JT10 Cluster: Phosphodiesterase, putative; n=2; Eukar...    89   8e-17
UniRef50_Q23917 Cluster: 3',5'-cyclic-nucleotide phosphodiestera...    89   8e-17
UniRef50_UPI00006CBCA5 Cluster: 3''''5''''-cyclic nucleotide pho...    89   1e-16
UniRef50_Q54HY3 Cluster: Putative uncharacterized protein Pde4; ...    89   1e-16
UniRef50_Q8I6Y6 Cluster: CGMP-specific phosphodiesterase; n=3; D...    89   1e-16
UniRef50_Q388U6 Cluster: 3', 5'-cyclic nucleotide phosphodiester...    89   1e-16
UniRef50_UPI000150A9A4 Cluster: 3''''5''''-cyclic nucleotide pho...    88   2e-16
UniRef50_Q01C40 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostr...    88   3e-16
UniRef50_Q5CXM2 Cluster: Membrane associated HD superfamily cycl...    88   3e-16
UniRef50_Q23AZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    88   3e-16
UniRef50_A0DIM1 Cluster: Chromosome undetermined scaffold_52, wh...    87   3e-16
UniRef50_A0CU34 Cluster: Chromosome undetermined scaffold_28, wh...    87   4e-16
UniRef50_A4RUJ3 Cluster: Predicted protein; n=1; Ostreococcus lu...    86   8e-16
UniRef50_A0EHP5 Cluster: Chromosome undetermined scaffold_97, wh...    86   8e-16
UniRef50_Q2V2M6 Cluster: CGMP-specific phosphodiesterase; n=3; P...    86   1e-15
UniRef50_A5K0J4 Cluster: 3',5'-cyclic-nucleotide phosphodiestera...    86   1e-15
UniRef50_A0CG66 Cluster: Chromosome undetermined scaffold_179, w...    86   1e-15
UniRef50_A7AS42 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    85   1e-15
UniRef50_Q4KL87 Cluster: MGC116558 protein; n=2; Xenopus|Rep: MG...    85   2e-15
UniRef50_Q4RR95 Cluster: Chromosome 14 SCAF15003, whole genome s...    85   2e-15
UniRef50_A0EGK4 Cluster: Chromosome undetermined scaffold_95, wh...    85   2e-15
UniRef50_O89085 Cluster: cAMP-specific 3',5'-cyclic phosphodiest...    84   4e-15
UniRef50_O76083 Cluster: High affinity cGMP-specific 3',5'-cycli...    83   9e-15
UniRef50_Q4RH59 Cluster: Chromosome undetermined SCAF15069, whol...    82   1e-14
UniRef50_Q22CV4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    82   2e-14
UniRef50_A5JZK3 Cluster: 3',5'-cyclic-nucleotide phosphodiestera...    81   2e-14
UniRef50_Q23RI8 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    81   3e-14
UniRef50_A7SVS5 Cluster: Predicted protein; n=1; Nematostella ve...    81   4e-14
UniRef50_UPI0000D577EC Cluster: PREDICTED: similar to CG32648-PA...    80   7e-14
UniRef50_Q01CI7 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostr...    80   7e-14
UniRef50_A2DYU6 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    79   9e-14
UniRef50_Q9VYJ0 Cluster: CG32648-PA; n=3; Coelomata|Rep: CG32648...    79   2e-13
UniRef50_Q5C1P7 Cluster: SJCHGC07646 protein; n=1; Schistosoma j...    79   2e-13
UniRef50_Q7PQX7 Cluster: ENSANGP00000010843; n=6; Coelomata|Rep:...    78   2e-13
UniRef50_Q53I59 Cluster: Cyclic nucleotide specific phosphodiest...    78   2e-13
UniRef50_A0DF61 Cluster: Chromosome undetermined scaffold_49, wh...    78   2e-13
UniRef50_A0CB76 Cluster: Chromosome undetermined scaffold_163, w...    78   2e-13
UniRef50_Q16VA1 Cluster: High-affinity cgmp-specific 3,5-cyclic ...    78   3e-13
UniRef50_UPI00006CB6E9 Cluster: 3''''5''''-cyclic nucleotide pho...    77   4e-13
UniRef50_A2D762 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    77   4e-13
UniRef50_A2DJF3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    76   8e-13
UniRef50_Q6CHK1 Cluster: Similar to tr|Q8NJP9 Candida albicans H...    76   8e-13
UniRef50_UPI00015B464B Cluster: PREDICTED: similar to ENSANGP000...    76   1e-12
UniRef50_UPI0000E48F4D Cluster: PREDICTED: similar to camp and c...    76   1e-12
UniRef50_A2ERL4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    75   2e-12
UniRef50_A0EF18 Cluster: Chromosome undetermined scaffold_92, wh...    75   2e-12
UniRef50_A4VDP2 Cluster: Cyclic nucleotide phosphodiesterase; n=...    75   3e-12
UniRef50_Q4SV96 Cluster: Chromosome 10 SCAF13771, whole genome s...    69   3e-12
UniRef50_O96077 Cluster: EFPDE3; n=1; Ephydatia fluviatilis|Rep:...    74   3e-12
UniRef50_A7RXZ4 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ...    74   3e-12
UniRef50_A7AR41 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    73   6e-12
UniRef50_Q57ZK5 Cluster: 3', 5'-cyclic nucleotide phosphodiester...    73   1e-11
UniRef50_A2FKH2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    73   1e-11
UniRef50_A2ENJ2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    73   1e-11
UniRef50_A2G2M9 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    72   1e-11
UniRef50_A2E4B2 Cluster: Response regulator receiver domain cont...    72   1e-11
UniRef50_UPI0000D555D7 Cluster: PREDICTED: similar to phosphodie...    71   2e-11
UniRef50_Q4FXD4 Cluster: Putative uncharacterized protein; n=3; ...    71   2e-11
UniRef50_A5JZK2 Cluster: 3',5'-cyclic-nucleotide phosphodiestera...    71   2e-11
UniRef50_A0E2C5 Cluster: Chromosome undetermined scaffold_74, wh...    71   2e-11
UniRef50_UPI00006CF33D Cluster: 3''''5''''-cyclic nucleotide pho...    71   3e-11
UniRef50_Q4T098 Cluster: Chromosome undetermined SCAF11274, whol...    71   3e-11
UniRef50_Q8IKD3 Cluster: Cyclic nucleotide phosphodiesterase, pu...    71   3e-11
UniRef50_A2F9J4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    71   3e-11
UniRef50_O00408 Cluster: cGMP-dependent 3',5'-cyclic phosphodies...    71   3e-11
UniRef50_A2E8N2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    71   4e-11
UniRef50_A2DG30 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    71   4e-11
UniRef50_UPI000065CC62 Cluster: cGMP-inhibited 3',5'-cyclic phos...    70   5e-11
UniRef50_Q4RSB8 Cluster: Chromosome 13 SCAF15000, whole genome s...    70   5e-11
UniRef50_Q8I0P7 Cluster: Probable 3',5'-cyclic phosphodiesterase...    70   5e-11
UniRef50_A5K353 Cluster: 3',5'-cyclic-nucleotide phosphodiestera...    70   7e-11
UniRef50_A2FBN7 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    70   7e-11
UniRef50_A0E1V7 Cluster: Chromosome undetermined scaffold_74, wh...    70   7e-11
UniRef50_A2EIP4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    69   9e-11
UniRef50_Q4N6H0 Cluster: Putative uncharacterized protein; n=1; ...    69   1e-10
UniRef50_A0CZB5 Cluster: Chromosome undetermined scaffold_32, wh...    69   1e-10
UniRef50_O94034 Cluster: Nucleotide phosphodiesterase; n=4; Sacc...    60   1e-10
UniRef50_A2DF08 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    69   2e-10
UniRef50_Q14432 Cluster: cGMP-inhibited 3',5'-cyclic phosphodies...    69   2e-10
UniRef50_UPI0000D8B81A Cluster: UPI0000D8B81A related cluster; n...    68   3e-10
UniRef50_O96076 Cluster: EFPDE2; n=1; Ephydatia fluviatilis|Rep:...    68   3e-10
UniRef50_A2FQ29 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    68   3e-10
UniRef50_A2DNV4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    68   3e-10
UniRef50_P30645 Cluster: Probable 3',5'-cyclic phosphodiesterase...    67   4e-10
UniRef50_Q9HCR9 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphod...    67   4e-10
UniRef50_UPI00006A17C5 Cluster: cGMP-inhibited 3',5'-cyclic phos...    67   5e-10
UniRef50_Q4SI77 Cluster: Chromosome 5 SCAF14581, whole genome sh...    67   5e-10
UniRef50_Q7QRM3 Cluster: GLP_481_5888_1773; n=1; Giardia lamblia...    56   6e-10
UniRef50_Q3KVL8 Cluster: High-affinity phosphodiesterase; n=4; E...    57   6e-10
UniRef50_Q4RHZ1 Cluster: Chromosome 8 SCAF15044, whole genome sh...    66   7e-10
UniRef50_A2EY05 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    66   7e-10
UniRef50_Q13370 Cluster: cGMP-inhibited 3',5'-cyclic phosphodies...    66   7e-10
UniRef50_UPI0001554EBF Cluster: PREDICTED: similar to cyclic nuc...    66   9e-10
UniRef50_A3FQ29 Cluster: CGMP phosphodiesterase A4; n=2; Cryptos...    66   9e-10
UniRef50_A2DBZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    66   9e-10
UniRef50_UPI00015B4531 Cluster: PREDICTED: similar to cyclic GMP...    65   2e-09
UniRef50_Q6S996 Cluster: Class I phosphodiesterase PDEB1; n=21; ...    65   2e-09
UniRef50_A2F408 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    65   2e-09
UniRef50_A0BZK9 Cluster: Chromosome undetermined scaffold_139, w...    65   2e-09
UniRef50_A5DVX9 Cluster: Putative uncharacterized protein; n=1; ...    65   2e-09
UniRef50_Q3SBD3 Cluster: Sperm phosphodiesterase 5; n=1; Strongy...    64   3e-09
UniRef50_A2E0V4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    64   3e-09
UniRef50_A0D565 Cluster: Chromosome undetermined scaffold_38, wh...    64   3e-09
UniRef50_Q4SPD6 Cluster: Chromosome 16 SCAF14537, whole genome s...    64   4e-09
UniRef50_Q17L35 Cluster: Cgmp-dependent 3,5-cyclic phosphodieste...    64   4e-09
UniRef50_Q4SVG8 Cluster: Chromosome undetermined SCAF13758, whol...    63   6e-09
UniRef50_Q9VFI9 Cluster: CG8279-PA; n=8; Endopterygota|Rep: CG82...    63   6e-09
UniRef50_UPI0000588CD9 Cluster: PREDICTED: hypothetical protein;...    63   8e-09
UniRef50_Q7Q8G2 Cluster: ENSANGP00000013023; n=2; Diptera|Rep: E...    63   8e-09
UniRef50_UPI0000F1D4E2 Cluster: PREDICTED: similar to Phosphodie...    62   1e-08
UniRef50_A2EHB3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    62   1e-08
UniRef50_O76074 Cluster: cGMP-specific 3',5'-cyclic phosphodiest...    62   2e-08
UniRef50_Q9VJ79 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphod...    62   2e-08
UniRef50_Q4DUD4 Cluster: CAMP-specific phosphodiesterase, putati...    61   3e-08
UniRef50_A7TPP3 Cluster: Putative uncharacterized protein; n=1; ...    61   3e-08
UniRef50_P06776 Cluster: 3',5'-cyclic-nucleotide phosphodiestera...    61   3e-08
UniRef50_Q95Z92 Cluster: Possible phosphodiesterase; n=2; Leishm...    61   3e-08
UniRef50_Q6FM93 Cluster: Similar to sp|P06776 Saccharomyces cere...    61   3e-08
UniRef50_P16499 Cluster: Rod cGMP-specific 3',5'-cyclic phosphod...    60   4e-08
UniRef50_Q7YYN8 Cluster: Phosphdiesterase, possible; n=2; Crypto...    60   8e-08
UniRef50_A3FPW6 Cluster: Phosphdiesterase, putative; n=1; Crypto...    60   8e-08
UniRef50_A2FQB0 Cluster: GAF domain containing protein; n=1; Tri...    60   8e-08
UniRef50_Q16HU8 Cluster: Camp and camp-inhibited cgmp 3,5-cyclic...    59   1e-07
UniRef50_UPI000023CCA1 Cluster: hypothetical protein FG06914.1; ...    59   1e-07
UniRef50_A2DM77 Cluster: GAF domain containing protein; n=1; Tri...    59   1e-07
UniRef50_Q1DXU2 Cluster: Putative uncharacterized protein; n=1; ...    59   1e-07
UniRef50_Q4DJ46 Cluster: Putative uncharacterized protein; n=2; ...    58   2e-07
UniRef50_Q4SVG0 Cluster: Chromosome 1 SCAF13759, whole genome sh...    58   2e-07
UniRef50_A4RPY9 Cluster: Putative uncharacterized protein; n=1; ...    58   2e-07
UniRef50_A2FK96 Cluster: GAF domain containing protein; n=3; Tri...    58   3e-07
UniRef50_A2DM90 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    58   3e-07
UniRef50_Q9Y233 Cluster: cAMP and cAMP-inhibited cGMP 3',5'-cycl...    57   4e-07
UniRef50_Q6BSL2 Cluster: Similar to tr|O94034 Candida albicans N...    57   5e-07
UniRef50_A1D4A4 Cluster: High affinity cAMP phosphodiesterase, p...    57   5e-07
UniRef50_Q2H9G5 Cluster: Putative uncharacterized protein; n=1; ...    56   9e-07
UniRef50_Q0V6F8 Cluster: Putative uncharacterized protein; n=1; ...    56   9e-07
UniRef50_UPI0000E46CDB Cluster: PREDICTED: similar to phosphodie...    56   1e-06
UniRef50_A6S8A0 Cluster: Putative uncharacterized protein; n=2; ...    55   2e-06
UniRef50_A7SW30 Cluster: Predicted protein; n=2; Nematostella ve...    54   4e-06
UniRef50_A0BZW8 Cluster: Chromosome undetermined scaffold_14, wh...    54   4e-06
UniRef50_Q6CY30 Cluster: Similar to sp|P06776 Saccharomyces cere...    54   4e-06
UniRef50_UPI00006CD10E Cluster: 3''''5''''-cyclic nucleotide pho...    54   5e-06
UniRef50_Q7RXW7 Cluster: Putative uncharacterized protein NCU004...    54   5e-06
UniRef50_P91119 Cluster: Probable 3',5'-cyclic phosphodiesterase...    54   5e-06
UniRef50_Q758Y3 Cluster: ADR395Cp; n=1; Eremothecium gossypii|Re...    53   7e-06
UniRef50_A2FSQ8 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    52   2e-05
UniRef50_A6R1R4 Cluster: Predicted protein; n=1; Ajellomyces cap...    52   2e-05
UniRef50_A2FET3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    51   3e-05
UniRef50_A2EA57 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    50   5e-05
UniRef50_Q4RG61 Cluster: Chromosome 2 SCAF15106, whole genome sh...    50   6e-05
UniRef50_UPI000065E700 Cluster: Cone cGMP-specific 3',5'-cyclic ...    50   8e-05
UniRef50_Q22VA7 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    49   1e-04
UniRef50_A2GFY4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras...    48   3e-04
UniRef50_A0D3N1 Cluster: Chromosome undetermined scaffold_36, wh...    48   3e-04
UniRef50_Q4QE95 Cluster: Putative uncharacterized protein; n=3; ...    47   6e-04
UniRef50_UPI0000D56333 Cluster: PREDICTED: similar to cGMP-depen...    44   0.003
UniRef50_UPI000065DEB3 Cluster: Dual 3',5'-cyclic-AMP and -GMP p...    31   0.20 
UniRef50_A4RH78 Cluster: Putative uncharacterized protein; n=1; ...    38   0.35 
UniRef50_A7CYI8 Cluster: Two component transcriptional regulator...    37   0.62 
UniRef50_A4RJX0 Cluster: Putative uncharacterized protein; n=2; ...    37   0.62 
UniRef50_A5KSE4 Cluster: Putative uncharacterized protein; n=1; ...    36   1.4  
UniRef50_Q5C091 Cluster: SJCHGC03341 protein; n=1; Schistosoma j...    36   1.4  
UniRef50_Q9TXJ7 Cluster: Sperm specific transcript protein 20; n...    35   2.5  
UniRef50_O27572 Cluster: Probable tRNA pseudouridine synthase D;...    35   2.5  
UniRef50_UPI00006CB312 Cluster: hypothetical protein TTHERM_0045...    34   3.3  
UniRef50_A6R697 Cluster: Predicted protein; n=1; Ajellomyces cap...    34   4.4  
UniRef50_Q5N7R3 Cluster: Putative uncharacterized protein P0034C...    33   5.8  
UniRef50_Q94241 Cluster: Putative uncharacterized protein; n=2; ...    33   5.8  
UniRef50_A2FIR1 Cluster: Putative uncharacterized protein; n=1; ...    33   5.8  
UniRef50_Q7SDI5 Cluster: Predicted protein; n=2; Sordariales|Rep...    33   5.8  
UniRef50_Q4WB96 Cluster: Pectin methylesterase, putative; n=1; A...    31   5.9  
UniRef50_A0VET3 Cluster: Conserved repeat domain precursor; n=1;...    33   7.6  

>UniRef50_Q9W4T4 Cluster: cAMP-specific 3',5'-cyclic
            phosphodiesterase, isoform I; n=38; Coelomata|Rep:
            cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I -
            Drosophila melanogaster (Fruit fly)
          Length = 1209

 Score =  194 bits (473), Expect = 2e-48
 Identities = 90/104 (86%), Positives = 95/104 (91%)
 Frame = +3

Query: 444  FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHD 623
            FL   S L++HY++DNPFHNSLHAADVTQSTNVLLNTPAL  VFTPLEV  ALFAAC+HD
Sbjct: 853  FLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHD 912

Query: 624  VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
            VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN G
Sbjct: 913  VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQG 956



 Score =  187 bits (455), Expect = 3e-46
 Identities = 99/164 (60%), Positives = 111/164 (67%), Gaps = 9/164 (5%)
 Frame = +1

Query: 4    MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKK-------- 159
            MLNKELSHFS+SS+SGNQISEYICSTFLDKQQE DLPSL+VE+  E  A           
Sbjct: 697  MLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAG 756

Query: 160  EKPRHGGP-ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVD 336
            +  R   P    MSQISGVKR L+HTNSFTGER+P +GVETP            D WG+ 
Sbjct: 757  QYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQ 816

Query: 337  IFRIGDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468
            IF IG+ S  RPLT VAYT F SRELLT+L IP +TFL F  TL
Sbjct: 817  IFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTL 860


>UniRef50_Q13945 Cluster: 3',5'-cyclic AMP phosphodiesterase; n=37;
           Coelomata|Rep: 3',5'-cyclic AMP phosphodiesterase - Homo
           sapiens (Human)
          Length = 606

 Score =  159 bits (387), Expect = 5e-38
 Identities = 76/110 (69%), Positives = 92/110 (83%)
 Frame = +3

Query: 423 SSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAAL 602
           SSDT   F+     L++HY  D  +HNSLHAADV QST+VLL+TPAL+AVFT LE+ AA+
Sbjct: 254 SSDT---FITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAI 310

Query: 603 FAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           FAA +HDVDHPG++NQFL+N++SELALMYNDESVLENHHLAV FKLLQ +
Sbjct: 311 FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 360



 Score =  119 bits (286), Expect = 9e-26
 Identities = 61/155 (39%), Positives = 96/155 (61%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183
           MLN+EL+H S+ S+SGNQ+SEYI +TFLDKQ ++++PS      +++  +KK+K +    
Sbjct: 123 MLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPS-----PTQKDREKKKKQQ---- 173

Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363
              M+QISGVK+ L H++S     + R+GV T +           ++WG++IF +   S 
Sbjct: 174 --LMTQISGVKK-LMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH 230

Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468
            RPLT + Y  F  R+LL T +I + TF+ + +TL
Sbjct: 231 NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTL 265


>UniRef50_P27815 Cluster: cAMP-specific 3',5'-cyclic
           phosphodiesterase 4A; n=160; Eumetazoa|Rep:
           cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Homo
           sapiens (Human)
          Length = 886

 Score =  158 bits (384), Expect = 1e-37
 Identities = 73/96 (76%), Positives = 85/96 (88%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           L++HY  D  +HNSLHAADV QST+VLL TPAL+AVFT LE+ AALFAA +HDVDHPG++
Sbjct: 422 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 481

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           NQFL+N++SELALMYNDESVLENHHLAV FKLLQ D
Sbjct: 482 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 517



 Score =  125 bits (302), Expect = 1e-27
 Identities = 62/159 (38%), Positives = 96/159 (60%), Gaps = 4/159 (2%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183
           MLN+EL+H S+ S+SGNQ+SEYI +TFLDKQ E+++PS  ++E  ++ A +    +   P
Sbjct: 265 MLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPP 324

Query: 184 ATT----MSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIG 351
                  MSQI+G+K+ L H+NS     +PR+GV+T             ++WG++IF + 
Sbjct: 325 PVPHLQPMSQITGLKK-LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVS 383

Query: 352 DLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468
           D + GR LT + Y  F  R+LL   +IP  T + + +TL
Sbjct: 384 DYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTL 422


>UniRef50_UPI000065D378 Cluster: cAMP-specific 3',5'-cyclic
           phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).;
           n=4; Euteleostomi|Rep: cAMP-specific 3',5'-cyclic
           phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46). -
           Takifugu rubripes
          Length = 715

 Score =  158 bits (383), Expect = 2e-37
 Identities = 72/96 (75%), Positives = 86/96 (89%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           L++HY  +  +HNSLHAADVTQST+VLL+TPAL+AVFT LE+ AALFAA +HDVDHPG++
Sbjct: 391 LEDHYHANVAYHNSLHAADVTQSTHVLLSTPALDAVFTDLEILAALFAAAIHDVDHPGVS 450

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           NQFL+N++SELALMYNDESVLENHHLAV FKLL  D
Sbjct: 451 NQFLINTNSELALMYNDESVLENHHLAVGFKLLHED 486



 Score =  129 bits (312), Expect = 6e-29
 Identities = 67/155 (43%), Positives = 98/155 (63%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183
           MLN+ELSH S+ S+SGNQ+SEYI +TFLDKQ E+++PS  + E        +EKP     
Sbjct: 254 MLNRELSHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTLRE--------REKP----- 300

Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363
              M QISGVK+ LTH++S +   +PR+GV+T H           ++WG++IF + +LS 
Sbjct: 301 ---MCQISGVKK-LTHSSSLSNSALPRFGVKTEHEDALARELNDLNKWGLNIFHVAELSN 356

Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468
            RPL+ + +  F  R+LL T +IP  TF+ + +TL
Sbjct: 357 NRPLSCIMFAIFQERDLLKTFRIPVDTFVTYVMTL 391


>UniRef50_Q4SP32 Cluster: Chromosome 15 SCAF14542, whole genome
           shotgun sequence; n=4; Tetraodontidae|Rep: Chromosome 15
           SCAF14542, whole genome shotgun sequence - Tetraodon
           nigroviridis (Green puffer)
          Length = 763

 Score =  158 bits (383), Expect = 2e-37
 Identities = 71/96 (73%), Positives = 85/96 (88%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           L+ HY  +  +HNSLHAADV QST++LL+TPALNAVFT LE+ AA+FAA +HDVDHPG++
Sbjct: 432 LESHYHSNVAYHNSLHAADVAQSTHILLSTPALNAVFTDLEILAAIFAAAIHDVDHPGVS 491

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           NQFL+N++SELALMYNDESVLENHHLAV FKLLQ D
Sbjct: 492 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 527



 Score =  127 bits (307), Expect = 3e-28
 Identities = 67/164 (40%), Positives = 103/164 (62%), Gaps = 7/164 (4%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKK-------KE 162
           MLN+ELSH S+ S+SGNQ+SEYI +TFLDKQ EL++P   V ++ +R  ++       ++
Sbjct: 273 MLNRELSHLSEMSRSGNQVSEYISNTFLDKQNELEIPC-PVPKSRDRKRRQGQQHQHQQQ 331

Query: 163 KPRHGGPATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIF 342
           + +H      M+QISGV++ L++T   +G    R+GV+T             ++WG++IF
Sbjct: 332 QQQHQQQGAMMTQISGVRK-LSNTPGTSGGPGNRFGVKTDQEELLSKDLEDINKWGINIF 390

Query: 343 RIGDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRS 474
           R+ + S  RPLT + YT F  R+L+ T +IPA TF+ F +TL S
Sbjct: 391 RVAEHSHNRPLTCIMYTIFQERDLMRTFKIPADTFVTFMLTLES 434


>UniRef50_Q3UEI1-2 Cluster: Isoform 2 of Q3UEI1 ; n=1; Mus
           musculus|Rep: Isoform 2 of Q3UEI1 - Mus musculus (Mouse)
          Length = 652

 Score =  149 bits (361), Expect = 7e-35
 Identities = 68/96 (70%), Positives = 80/96 (83%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           L+ HY  D  +HNS+HAADV QS +VLL TPAL AVFT LEV AA+FA  +HDVDHPG++
Sbjct: 378 LEGHYHSDVAYHNSMHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVS 437

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           NQFL+N++SELALMYND SVLENHHLAV FKLLQ +
Sbjct: 438 NQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGE 473



 Score =  115 bits (276), Expect = 1e-24
 Identities = 64/155 (41%), Positives = 96/155 (61%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183
           MLN+ELS+ S++S+SGNQ+SEYI  TFLD+Q E++LP               + P    P
Sbjct: 242 MLNRELSYLSETSRSGNQVSEYISQTFLDQQAEVELP---------------QPPTEDDP 286

Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363
              M+QI+ ++R+ +HT+  T   +PR+GV+T             ++WG+D+F++ +LS 
Sbjct: 287 -WPMAQITELRRS-SHTSLPTAA-IPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSG 343

Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468
            RPLTAV ++ F  R+LL T QIPA T LA+ +TL
Sbjct: 344 NRPLTAVIFSVFQERDLLKTFQIPADTLLAYLLTL 378


>UniRef50_Q22000 Cluster: Probable 3',5'-cyclic phosphodiesterase
           pde-4; n=7; Caenorhabditis elegans|Rep: Probable
           3',5'-cyclic phosphodiesterase pde-4 - Caenorhabditis
           elegans
          Length = 674

 Score =  144 bits (348), Expect = 3e-33
 Identities = 65/93 (69%), Positives = 78/93 (83%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650
           EH+ R+N +HN +HAADV QS +VLL +P L  VFT LEV AA+FA  VHDVDHPG TNQ
Sbjct: 398 EHHYRNNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQ 457

Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           +L+NS++ELA+MYNDESVLE HHLAVAFKLLQ+
Sbjct: 458 YLINSNNELAIMYNDESVLEQHHLAVAFKLLQD 490



 Score = 87.8 bits (208), Expect = 3e-16
 Identities = 54/160 (33%), Positives = 82/160 (51%), Gaps = 5/160 (3%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPR---- 171
           MLNKELSHF++SSKSG Q+S+++ +T++DK++  D PS+++E  +E        P     
Sbjct: 245 MLNKELSHFAESSKSGTQVSKFLITTYMDKEE--DEPSIEIEVPTEVQGPSTSGPMTLSI 302

Query: 172 -HGGPATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRI 348
                   M++ISGV++      S  G  VP YGV               D WG D+F+I
Sbjct: 303 LKKAQTAAMNKISGVRK--LRAPSHDG-HVPEYGVNCAR--EIAVHMQRLDDWGPDVFKI 357

Query: 349 GDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTL 468
            +LS    LT V ++    R L  T +I   T + + + L
Sbjct: 358 DELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNL 397


>UniRef50_O96078 Cluster: EFPDE4; n=1; Ephydatia fluviatilis|Rep:
           EFPDE4 - Ephydatia fluviatilis
          Length = 698

 Score =  127 bits (306), Expect = 3e-28
 Identities = 60/102 (58%), Positives = 76/102 (74%)
 Frame = +3

Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHD 623
           FL   S ++  Y   NP+HN+LHAADV  +TN LL   AL  +FT LEV AAL AA +HD
Sbjct: 398 FLNFISTIESKY-HSNPYHNALHAADVLLATNHLLKAKALEPIFTQLEVFAALVAAIIHD 456

Query: 624 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           VDHPG  NQFLV++   LA++YNDESVLENHHLA+AF+L+++
Sbjct: 457 VDHPGRNNQFLVSTEDPLAILYNDESVLENHHLALAFELMKD 498



 Score = 50.4 bits (115), Expect = 5e-05
 Identities = 36/158 (22%), Positives = 72/158 (45%), Gaps = 1/158 (0%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICS-TFLDKQQELDLPSLQVEETSERGAKKKEKPRHGG 180
           ++++EL+  S+ S SG++++E++   T  D+  E+D          ER +  ++ P    
Sbjct: 261 VMSRELTQLSERSLSGHRVAEWVQDITRSDRDDEID-------RAIERSSIAEQDPEAQS 313

Query: 181 PATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLS 360
           P T +   + ++   +  +      V +  + +             + W +DIF +  +S
Sbjct: 314 PTTVVQPTAMLEGAASSVSQDLLHEVVKNKINSEDVTEFFKQ----EAWDMDIFLLDTVS 369

Query: 361 CGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRS 474
              PL A AY  F +R+L + ++I    FL F  T+ S
Sbjct: 370 GNSPLVAAAYHVFKARDLFSEMKIVPSVFLNFISTIES 407


>UniRef50_A7SVX8 Cluster: Predicted protein; n=1; Nematostella
           vectensis|Rep: Predicted protein - Nematostella
           vectensis
          Length = 844

 Score =  113 bits (272), Expect = 4e-24
 Identities = 53/96 (55%), Positives = 67/96 (69%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++ +Y R N +HNS HAADV  +T V L    + AV  PL+  A+L AA VHDVDHPG T
Sbjct: 570 IEANYHRKNAYHNSTHAADVLHATAVFLAKERVKAVLEPLDEVASLIAAIVHDVDHPGYT 629

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           N FL N+ SELA++YND +VLE+HH A+AFKL   D
Sbjct: 630 NSFLCNAGSELAILYNDIAVLESHHAALAFKLTARD 665


>UniRef50_O43862 Cluster: 3'5' cyclic nucleotide phosphodiesterase
           4D splice variant 1; n=8; Euteleostomi|Rep: 3'5' cyclic
           nucleotide phosphodiesterase 4D splice variant 1 - Homo
           sapiens (Human)
          Length = 205

 Score =  111 bits (267), Expect = 2e-23
 Identities = 57/132 (43%), Positives = 86/132 (65%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183
           MLN+EL+H S+ S+SGNQ+SE+I +TFLDKQ E+++PS      +++  +KK++P     
Sbjct: 87  MLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPS-----PTQKEKEKKKRP----- 136

Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363
              MSQISGVK+ L H++S T   +PR+GV+T             ++WG+ +FRI +LS 
Sbjct: 137 ---MSQISGVKK-LMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSG 192

Query: 364 GRPLTAVAYTAF 399
            RPLT + +T F
Sbjct: 193 NRPLTVIMHTIF 204


>UniRef50_O43851 Cluster: PDE4C-delta109; n=18; Bilateria|Rep:
           PDE4C-delta109 - Homo sapiens (Human)
          Length = 427

 Score =  105 bits (253), Expect = 9e-22
 Identities = 47/60 (78%), Positives = 55/60 (91%)
 Frame = +3

Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           AVFT LE+ AALFA+ +HDVDHPG++NQFL+N++SELALMYND SVLENHHLAV FKLLQ
Sbjct: 126 AVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQ 185



 Score = 99.1 bits (236), Expect = 1e-19
 Identities = 55/148 (37%), Positives = 87/148 (58%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183
           +LN+EL+H S++S+SGNQ+SEYI  TFLD+Q E++LP +  EE  +              
Sbjct: 10  ILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ-------------- 55

Query: 184 ATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHXXXXXXXXXXXDRWGVDIFRIGDLSC 363
              MS+ISG+   L H+ S +   VPR+GV+T             ++WG+D+F++ +LS 
Sbjct: 56  --PMSRISGL-HGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSG 112

Query: 364 GRPLTAVAYTAFTSRELLTTLQIPARTF 447
            +PLTA+ ++ F  + + T L+I A  F
Sbjct: 113 NQPLTAIIFSIF--QAVFTDLEILAALF 138


>UniRef50_Q9N2V9 Cluster: Probable 3',5'-cyclic phosphodiesterase
           pde-6; n=3; Caenorhabditis|Rep: Probable 3',5'-cyclic
           phosphodiesterase pde-6 - Caenorhabditis elegans
          Length = 760

 Score =  104 bits (249), Expect = 3e-21
 Identities = 44/92 (47%), Positives = 64/92 (69%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++ HY   N +HN+ HAADV Q+T+  L++P++          AAL AA VHD+DHPG  
Sbjct: 491 IEAHYHAGNTYHNATHAADVLQATSFFLDSPSVAVHVNESHAVAALLAAAVHDLDHPGRG 550

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           N +L+N+   LA++YND S+LENHH+A+AF+L
Sbjct: 551 NAYLINTRQSLAILYNDNSILENHHIALAFQL 582


>UniRef50_UPI0000D56A7E Cluster: PREDICTED: similar to High-affinity
           cAMP-specific and IBMX-insensitive 3,5-cyclic
           phosphodiesterase 8A; n=1; Tribolium castaneum|Rep:
           PREDICTED: similar to High-affinity cAMP-specific and
           IBMX-insensitive 3,5-cyclic phosphodiesterase 8A -
           Tribolium castaneum
          Length = 862

 Score =  103 bits (246), Expect = 6e-21
 Identities = 46/96 (47%), Positives = 63/96 (65%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++ +Y  DN +HNS HAADV Q+T   L    L ++  PL+   +L AA  HDVDHPG +
Sbjct: 568 IEANYHTDNTYHNSTHAADVMQATAGFLEREKLKSIMDPLDEATSLIAAAAHDVDHPGKS 627

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           N FL NS + LA++YND ++LE+HH A+ FKL   D
Sbjct: 628 NAFLSNSDNPLAILYNDITILESHHAALMFKLTLGD 663


>UniRef50_UPI0000519BD4 Cluster: PREDICTED: similar to
           phosphodiesterase 8A; n=1; Apis mellifera|Rep:
           PREDICTED: similar to phosphodiesterase 8A - Apis
           mellifera
          Length = 820

 Score =  103 bits (246), Expect = 6e-21
 Identities = 46/96 (47%), Positives = 65/96 (67%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++ +Y   N +HNS HAADV Q+  + + T  L  V  PL+  A L AA  HD+DHPG +
Sbjct: 525 IEANYDITNRYHNSTHAADVLQAAAMFMQTERLKQVLEPLDEVATLIAAAAHDIDHPGRS 584

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           +QFL NS ++LA++YND +VLE+HH A+ FKL  +D
Sbjct: 585 SQFLCNSDNKLAILYNDLTVLESHHAALTFKLTLSD 620


>UniRef50_A7SGA1 Cluster: Predicted protein; n=1; Nematostella
           vectensis|Rep: Predicted protein - Nematostella
           vectensis
          Length = 358

 Score =  103 bits (246), Expect = 6e-21
 Identities = 44/88 (50%), Positives = 62/88 (70%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NP+HN  HAADVT + +  L    ++   + LEV   L +A +HD++H G TN F +NS 
Sbjct: 137 NPYHNDCHAADVTHTVHYFLECMGVSKYLSDLEVFGLLLSAIIHDLEHTGTTNAFHINSR 196

Query: 669 SELALMYNDESVLENHHLAVAFKLLQND 752
           S+LAL+YND SVLENHH++ AF++LQ+D
Sbjct: 197 SDLALLYNDRSVLENHHVSCAFRILQDD 224


>UniRef50_Q14123 Cluster: Calcium/calmodulin-dependent 3',5'-cyclic
           nucleotide phosphodiesterase 1C; n=128;
           Euteleostomi|Rep: Calcium/calmodulin-dependent
           3',5'-cyclic nucleotide phosphodiesterase 1C - Homo
           sapiens (Human)
          Length = 709

 Score =  102 bits (245), Expect = 8e-21
 Identities = 44/88 (50%), Positives = 63/88 (71%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NP+HN +HAADVTQ+ + LL    +    T LE+ A +F+A +HD +H G TN F + + 
Sbjct: 225 NPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTR 284

Query: 669 SELALMYNDESVLENHHLAVAFKLLQND 752
           S+ A++YND SVLENHHL+ A++LLQ+D
Sbjct: 285 SDPAILYNDRSVLENHHLSAAYRLLQDD 312


>UniRef50_O95263 Cluster: High affinity cAMP-specific and
           IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B;
           n=83; Euteleostomi|Rep: High affinity cAMP-specific and
           IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B -
           Homo sapiens (Human)
          Length = 885

 Score =  102 bits (244), Expect = 1e-20
 Identities = 48/96 (50%), Positives = 62/96 (64%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++ +Y   N +HNS HAADV  +T   L    +      L+  AAL AA VHDVDHPG T
Sbjct: 604 IEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRT 663

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           N FL N+ SELA++YND +VLE+HH A+AF+L   D
Sbjct: 664 NSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 699


>UniRef50_Q8CFW8 Cluster: Phosphodiesterase 8B; n=13;
           Euteleostomi|Rep: Phosphodiesterase 8B - Mus musculus
           (Mouse)
          Length = 730

 Score =  100 bits (240), Expect = 3e-20
 Identities = 47/96 (48%), Positives = 61/96 (63%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++ +Y   N +HNS HAADV  +T   L    +      L+  AAL AA VHDVDHPG T
Sbjct: 449 IEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRT 508

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           N FL N+ SELA++YND +VLE+HH A+ F+L   D
Sbjct: 509 NSFLCNAGSELAVLYNDTAVLESHHTALVFQLTVKD 544


>UniRef50_UPI0000DB7125 Cluster: PREDICTED: similar to
           Phosphodiesterase 1c CG14940-PA; n=1; Apis
           mellifera|Rep: PREDICTED: similar to Phosphodiesterase
           1c CG14940-PA - Apis mellifera
          Length = 731

 Score =  100 bits (239), Expect = 4e-20
 Identities = 46/97 (47%), Positives = 66/97 (68%), Gaps = 1/97 (1%)
 Frame = +3

Query: 465 LKEHYIRD-NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641
           ++E Y R  NP+HN+LHAADV Q+ + +L    L    T LE+ A L AA +HD +H G 
Sbjct: 429 VEEGYCRHRNPYHNNLHAADVAQTMHYILCQTGLMNWLTDLEIFATLVAAIIHDYEHTGT 488

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           TN F V S S+ AL+YND +VLENHH++ +F++++ D
Sbjct: 489 TNNFHVMSGSDTALLYNDRAVLENHHISASFRIMRED 525


>UniRef50_O18696 Cluster: Probable 3',5'-cyclic phosphodiesterase
           pde-1; n=2; Caenorhabditis|Rep: Probable 3',5'-cyclic
           phosphodiesterase pde-1 - Caenorhabditis elegans
          Length = 664

 Score =  100 bits (239), Expect = 4e-20
 Identities = 43/89 (48%), Positives = 62/89 (69%)
 Frame = +3

Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665
           +NP+HN +HAADVTQS++ +L+   L      LE+ A LF A +HD +H G TN F + S
Sbjct: 329 NNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQS 388

Query: 666 SSELALMYNDESVLENHHLAVAFKLLQND 752
            S+ A++YND SVLENHH++  F+L++ D
Sbjct: 389 QSQFAMLYNDRSVLENHHVSSCFRLMKED 417


>UniRef50_UPI0000DB6B8B Cluster: PREDICTED: similar to
           phosphodiesterase 7A isoform a; n=1; Apis mellifera|Rep:
           PREDICTED: similar to phosphodiesterase 7A isoform a -
           Apis mellifera
          Length = 1148

 Score = 99.5 bits (237), Expect = 8e-20
 Identities = 49/123 (39%), Positives = 69/123 (56%)
 Frame = +3

Query: 387 VHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN 566
           VH  H  G + Y +        + ++++E Y   NP+HNS+HA DVTQ+ +  L    + 
Sbjct: 60  VHLFHWYGLLQYFNLDVVTVWKLFAFIEEGYHSTNPYHNSIHATDVTQAMHCFLQEEKIR 119

Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
              T LE+ A+L AA  HD+DHPG+   FLV +S+ LA +Y + SVLENHH   A   L 
Sbjct: 120 THLTNLEIMASLIAAVTHDLDHPGVNQPFLVATSNHLAALYQNTSVLENHHWRSAIGCLL 179

Query: 747 NDG 755
             G
Sbjct: 180 ESG 182


>UniRef50_Q005X2 Cluster: Phosphodiesterase 1; n=1;
           Strongylocentrotus purpuratus|Rep: Phosphodiesterase 1 -
           Strongylocentrotus purpuratus (Purple sea urchin)
          Length = 680

 Score = 99.5 bits (237), Expect = 8e-20
 Identities = 43/88 (48%), Positives = 64/88 (72%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NP+HN LHAADVTQ+ + +L    L    + LE+ A+L AA +HD +H G TN F VN+ 
Sbjct: 283 NPYHNLLHAADVTQTVHHMLARMGLVHWLSDLEIFASLLAAIIHDFEHTGTTNAFHVNTK 342

Query: 669 SELALMYNDESVLENHHLAVAFKLLQND 752
           S++A+ YND +VLENHH++ +F+L+++D
Sbjct: 343 SDMAMFYNDRAVLENHHISSSFRLMRDD 370


>UniRef50_Q8SXR0 Cluster: RE69157p; n=9; Coelomata|Rep: RE69157p -
           Drosophila melanogaster (Fruit fly)
          Length = 834

 Score = 98.7 bits (235), Expect = 1e-19
 Identities = 48/97 (49%), Positives = 64/97 (65%), Gaps = 1/97 (1%)
 Frame = +3

Query: 465 LKEHYIR-DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641
           ++E Y R  NP+HN+LHA DV Q+ +  L    L    T LE+ A+L AA +HD +H G 
Sbjct: 457 VEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGT 516

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           TN F V S SE AL+YND +VLENHH + +F+LL+ D
Sbjct: 517 TNNFHVMSGSETALLYNDRAVLENHHASASFRLLRED 553


>UniRef50_UPI0000E7FF0E Cluster: PREDICTED: similar to cAMP
           phosphodiesterase PDE7, partial; n=1; Gallus gallus|Rep:
           PREDICTED: similar to cAMP phosphodiesterase PDE7,
           partial - Gallus gallus
          Length = 482

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 44/97 (45%), Positives = 62/97 (63%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++E Y   NP+HN++HAADVTQ+ +  L  P L+   TP +V  +L AA  HD+DHPG+ 
Sbjct: 2   VQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLSESLTPWDVLLSLIAAATHDLDHPGVN 61

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
             FL+ ++  LA +Y + SVLENHH   A  LL+  G
Sbjct: 62  QPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG 98



 Score = 64.5 bits (150), Expect = 3e-09
 Identities = 29/69 (42%), Positives = 42/69 (60%)
 Frame = +3

Query: 549 NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728
           ++  L+   TP +V  +L AA  HD+DHPG+   FL+ ++  LA +Y + SVLENHH   
Sbjct: 227 HSECLSESLTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRS 286

Query: 729 AFKLLQNDG 755
           A  LL+  G
Sbjct: 287 AVGLLRESG 295


>UniRef50_Q6NNF2 Cluster: SD02170p; n=9; Diptera|Rep: SD02170p -
           Drosophila melanogaster (Fruit fly)
          Length = 914

 Score = 97.9 bits (233), Expect = 2e-19
 Identities = 47/98 (47%), Positives = 61/98 (62%), Gaps = 2/98 (2%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLN--TPALNAVFTPLEVCAALFAACVHDVDHPG 638
           ++ HY + N +HNS HAADV Q+T   +   T     V   +E   AL AA  HDVDHPG
Sbjct: 629 IEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPG 688

Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
            ++ FL NS+  LA++YND +VLENHH A+ FKL   D
Sbjct: 689 RSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGD 726


>UniRef50_Q16J23 Cluster: Camp-specific 3,5-cyclic
           phosphodiesterase; n=2; Culicidae|Rep: Camp-specific
           3,5-cyclic phosphodiesterase - Aedes aegypti
           (Yellowfever mosquito)
          Length = 872

 Score = 97.5 bits (232), Expect = 3e-19
 Identities = 48/123 (39%), Positives = 69/123 (56%)
 Frame = +3

Query: 387 VHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN 566
           VH  H  G +D+ +        + S ++E Y   NP+HNS+HA DVTQ+ +  L    + 
Sbjct: 131 VHLFHWYGLLDHFNLDVVRVWKLFSLIEEGYHSTNPYHNSIHATDVTQAMHCFLQEKRIL 190

Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
              +PLE+ A+L  A  HD+DHPG+   FL+ +S+ LA +Y + SVLENHH   A   L 
Sbjct: 191 ENLSPLEIMASLIGAVTHDLDHPGVNQPFLIATSNHLAALYENTSVLENHHWRSAVGCLL 250

Query: 747 NDG 755
             G
Sbjct: 251 ESG 253


>UniRef50_O96075 Cluster: EFPDE1; n=1; Ephydatia fluviatilis|Rep:
           EFPDE1 - Ephydatia fluviatilis
          Length = 628

 Score = 96.7 bits (230), Expect = 5e-19
 Identities = 45/93 (48%), Positives = 62/93 (66%)
 Frame = +3

Query: 474 HYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQF 653
           + +  NP+HNS HAADV Q+ + L+++  L    + LEV A L AA VHD++H G TN F
Sbjct: 271 YQLHGNPYHNSTHAADVLQTVHYLISSTGLEHWISSLEVLAILLAATVHDLEHTGTTNTF 330

Query: 654 LVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
            + S ++ AL+YND +VLEN HL  AF LL+ D
Sbjct: 331 HIQSYTDYALLYNDRAVLENFHLNRAFTLLKED 363


>UniRef50_Q13946 Cluster: High affinity cAMP-specific 3',5'-cyclic
           phosphodiesterase 7A; n=73; Euteleostomi|Rep: High
           affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
           - Homo sapiens (Human)
          Length = 482

 Score = 96.3 bits (229), Expect = 7e-19
 Identities = 43/97 (44%), Positives = 61/97 (62%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++E Y   NP+HN++HAADVTQ+ +  L  P L    TP ++  +L AA  HD+DHPG+ 
Sbjct: 201 IQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVN 260

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
             FL+ ++  LA +Y + SVLENHH   A  LL+  G
Sbjct: 261 QPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG 297


>UniRef50_UPI00015B4893 Cluster: PREDICTED: similar to camp-specific
           3,5-cyclic phosphodiesterase; n=1; Nasonia
           vitripennis|Rep: PREDICTED: similar to camp-specific
           3,5-cyclic phosphodiesterase - Nasonia vitripennis
          Length = 1229

 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 48/123 (39%), Positives = 70/123 (56%)
 Frame = +3

Query: 387 VHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN 566
           VH  H  G +++ +        + + ++E Y   NP+HNS+HAADVTQ+ +  L    + 
Sbjct: 255 VHLFHWYGLLEHFNLDVVRVWKLFTLIEEGYHSTNPYHNSIHAADVTQAMHCFLQEEQIR 314

Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
              + LE+ A+L AA  HD+DHPG+   FLV +S+ LA +Y + SVLENHH   A   L 
Sbjct: 315 RHLSYLEIMASLIAAVTHDLDHPGVNQPFLVATSNHLAALYENTSVLENHHWRSAVGCLL 374

Query: 747 NDG 755
             G
Sbjct: 375 ESG 377


>UniRef50_UPI00015B5210 Cluster: PREDICTED: similar to
           ENSANGP00000018818; n=2; Nasonia vitripennis|Rep:
           PREDICTED: similar to ENSANGP00000018818 - Nasonia
           vitripennis
          Length = 849

 Score = 91.9 bits (218), Expect = 2e-17
 Identities = 40/96 (41%), Positives = 63/96 (65%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++ +Y     +HNS HA DV Q+    + +  +  +  PL+  AAL AA  HD+ HPG +
Sbjct: 568 IEANYNSHVSYHNSTHATDVLQACARFMRSDRIQQILDPLDEVAALLAAAAHDIGHPGKS 627

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           +QFL N+S++LA++YND +VLE+HH A+ FK+  +D
Sbjct: 628 SQFLCNTSNKLAILYNDLTVLESHHSALTFKVTLSD 663


>UniRef50_A4RV03 Cluster: Predicted protein; n=1; Ostreococcus
           lucimarinus CCE9901|Rep: Predicted protein -
           Ostreococcus lucimarinus CCE9901
          Length = 401

 Score = 91.9 bits (218), Expect = 2e-17
 Identities = 44/94 (46%), Positives = 59/94 (62%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650
           E   RDNP+H   HA DVT +T + +         T +E+ + L AA VHD+DHPG+TN 
Sbjct: 62  EGMYRDNPYHCFKHAVDVTHTTYLYICAVKEQVSMTQVEIFSLLVAALVHDLDHPGVTNG 121

Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           +L+ +   +AL YNDESVLEN HL+  F L QN+
Sbjct: 122 YLIATHDNIALTYNDESVLENLHLSRFFSLCQNN 155


>UniRef50_UPI000150A113 Cluster: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein; n=1; Tetrahymena
           thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein - Tetrahymena
           thermophila SB210
          Length = 569

 Score = 91.5 bits (217), Expect = 2e-17
 Identities = 40/98 (40%), Positives = 65/98 (66%), Gaps = 2/98 (2%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPG 638
           +++ Y+  NP+HN +HA DVTQ+ +  L       +     +++     AA +HDV+HPG
Sbjct: 256 IQQKYL-GNPYHNKIHAFDVTQTMHFFLKKCNFVQIGKLNKIDIGTVFVAAAIHDVEHPG 314

Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
             N F +N+ ++LA++YND+S LENHHL+V FKLL+++
Sbjct: 315 FNNPFQMNAKTDLAILYNDKSPLENHHLSVTFKLLRDN 352


>UniRef50_Q4N806 Cluster: 3',5' cyclic nucleotide phosphodiesterase,
           putative; n=2; Theileria|Rep: 3',5' cyclic nucleotide
           phosphodiesterase, putative - Theileria parva
          Length = 450

 Score = 91.5 bits (217), Expect = 2e-17
 Identities = 44/121 (36%), Positives = 71/121 (58%)
 Frame = +3

Query: 390 HSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNA 569
           H +H  G + + +      + V   L++HY+  NP+HN+LHAA V   + +L N      
Sbjct: 136 HLLHCVGNLIHPN-FNTNLIPVLQNLQQHYLA-NPYHNALHAATVGHMSKLLSNIVTTKR 193

Query: 570 VFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
              P E  A + ++  HDV HPG TN +L N+S+ L+L+YND S LEN+H ++ F +++N
Sbjct: 194 RLNPYEEFAFIISSLAHDVGHPGKTNNYLSNTSNVLSLIYNDNSTLENYHCSLLFYIIKN 253

Query: 750 D 752
           +
Sbjct: 254 N 254


>UniRef50_Q6S998 Cluster: CAMP-specific phosphodiesterase; n=3;
           Leishmania|Rep: CAMP-specific phosphodiesterase -
           Leishmania major
          Length = 631

 Score = 91.1 bits (216), Expect = 3e-17
 Identities = 41/89 (46%), Positives = 60/89 (67%), Gaps = 2/89 (2%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           NP+HNS+HAADV Q T+ ++    L      + ++V +AL AA +HD DHPG+ N F + 
Sbjct: 382 NPYHNSMHAADVLQITDFIITQGGLAKRCDLSDIQVFSALLAASIHDFDHPGINNNFHIK 441

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749
           + S LA +YND SVLEN H++  F+L++N
Sbjct: 442 TGSYLATLYNDRSVLENLHVSSVFELMKN 470


>UniRef50_A0EBQ7 Cluster: Chromosome undetermined scaffold_88, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_88,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 744

 Score = 91.1 bits (216), Expect = 3e-17
 Identities = 43/99 (43%), Positives = 63/99 (63%)
 Frame = +3

Query: 456 CSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635
           C  ++  Y++ NP+HNS+HA DV  S +  L         TP E C  + +A  HDV HP
Sbjct: 453 CHRIESFYMQ-NPYHNSIHAMDVANSASFFLEN---GLEVTPFEQCCLIISALSHDVGHP 508

Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           GL N FLV S S+ AL+YND+SVLE++H ++ F +L+++
Sbjct: 509 GLNNGFLVASQSKQALIYNDQSVLESYHASLMFHVLKDE 547


>UniRef50_A0CZ03 Cluster: Chromosome undetermined scaffold_31, whole
           genome shotgun sequence; n=4; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_31,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 692

 Score = 90.6 bits (215), Expect = 4e-17
 Identities = 46/100 (46%), Positives = 60/100 (60%), Gaps = 4/100 (4%)
 Frame = +3

Query: 453 VCSYLKE--HYIRDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVH 620
           V SY +E     +DNP+HN +HA DV Q+ N LLN      +      ++   L A  +H
Sbjct: 417 VRSYFEEVMRGYQDNPYHNRVHAQDVAQTCNFLLNRCKFIEIGQLDEQDIACVLIAGAIH 476

Query: 621 DVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           D  HPGLTN FL+NS +ELAL YND+SVLE  H +  FK+
Sbjct: 477 DYGHPGLTNAFLINSKNELALTYNDQSVLEMFHPSQCFKI 516


>UniRef50_Q57V52 Cluster: 3', 5'-cyclic nucleotide
           phosphodiesterase, putative; n=3; Trypanosoma|Rep: 3',
           5'-cyclic nucleotide phosphodiesterase, putative -
           Trypanosoma brucei
          Length = 676

 Score = 89.8 bits (213), Expect = 6e-17
 Identities = 41/89 (46%), Positives = 57/89 (64%), Gaps = 2/89 (2%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALN--AVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           NP+HNS+HAADVTQ    ++    +       P E   A+ AA VHD DHPGL N F   
Sbjct: 428 NPYHNSMHAADVTQVNYYIIFIAGMKERCQLRPEEQLGAVLAAAVHDFDHPGLNNNFHTR 487

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749
           +++ L+ +YND S+LENHH+A  F+LL++
Sbjct: 488 TNAYLSTLYNDRSILENHHIASVFQLLKH 516


>UniRef50_Q4D500 Cluster: Phosphodiesterase, putative; n=3;
           Trypanosoma cruzi|Rep: Phosphodiesterase, putative -
           Trypanosoma cruzi
          Length = 708

 Score = 89.8 bits (213), Expect = 6e-17
 Identities = 40/89 (44%), Positives = 61/89 (68%), Gaps = 2/89 (2%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           NP+HNS+HAADV   T+ +L+   +      + L+V AALFAA +HD +HPG+ N F + 
Sbjct: 459 NPYHNSMHAADVLHITHYILSKGGMIERCQLSDLQVFAALFAAAIHDYNHPGVNNNFHIK 518

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749
           + +  A++YND SVLEN H++  F+L++N
Sbjct: 519 TQTYSAIVYNDRSVLENAHVSSVFELMKN 547


>UniRef50_A4HHP3 Cluster: Putative uncharacterized protein; n=3;
           Leishmania|Rep: Putative uncharacterized protein -
           Leishmania braziliensis
          Length = 734

 Score = 89.8 bits (213), Expect = 6e-17
 Identities = 41/89 (46%), Positives = 56/89 (62%), Gaps = 2/89 (2%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNA--VFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           NP+HN++H ADVTQ    ++    L+     +  E+ A + A  VHD DHPGL N F   
Sbjct: 459 NPYHNAMHGADVTQINYYIMIVAGLSVKCCLSNEEIFAGIIAGAVHDFDHPGLNNNFHSR 518

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749
           + + LA +YND S+LENHHLA  F+LL+N
Sbjct: 519 TGAYLATLYNDRSILENHHLACTFELLRN 547


>UniRef50_Q1JT10 Cluster: Phosphodiesterase, putative; n=2;
            Eukaryota|Rep: Phosphodiesterase, putative - Toxoplasma
            gondii RH
          Length = 2092

 Score = 89.4 bits (212), Expect = 8e-17
 Identities = 42/97 (43%), Positives = 57/97 (58%)
 Frame = +3

Query: 465  LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
            +++ Y  DNP+HN  HA  V Q   + L+      + +P+E    L AA  HDVDHPG+ 
Sbjct: 1747 IRDGYHTDNPYHNFYHAIHVFQVCWMFLSAYGCRNILSPIEQLGILLAALCHDVDHPGVN 1806

Query: 645  NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
            N FL  S   L++MYND+SVLENHH A A + +   G
Sbjct: 1807 NAFLRASLHPLSIMYNDKSVLENHHAAFAIRTMMQLG 1843


>UniRef50_Q23917 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase
           regA; n=2; Dictyostelium discoideum|Rep:
           3',5'-cyclic-nucleotide phosphodiesterase regA -
           Dictyostelium discoideum (Slime mold)
          Length = 793

 Score = 89.4 bits (212), Expect = 8e-17
 Identities = 41/91 (45%), Positives = 57/91 (62%)
 Frame = +3

Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656
           Y ++N +HN  HA DVTQ+    L +       T L++ A L +   HD++HPG  N F 
Sbjct: 480 YRKNNRYHNFTHAFDVTQTVYTFLTSFNAAQYLTHLDIFALLISCMCHDLNHPGFNNTFQ 539

Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           VN+ +EL+L YND SVLENHH  + FK+L+N
Sbjct: 540 VNAQTELSLEYNDISVLENHHAMLTFKILRN 570


>UniRef50_UPI00006CBCA5 Cluster: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein; n=1; Tetrahymena
           thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein - Tetrahymena
           thermophila SB210
          Length = 649

 Score = 89.0 bits (211), Expect = 1e-16
 Identities = 40/90 (44%), Positives = 55/90 (61%), Gaps = 2/90 (2%)
 Frame = +3

Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALN--AVFTPLEVCAALFAACVHDVDHPGLTNQFLV 659
           DN +HN LHA DV Q+ N  L +      A     ++C    +A  HD DHPG+ N F++
Sbjct: 379 DNLYHNRLHAFDVLQTANFFLKSCNFIEIAAINEFDLCTIYISAACHDYDHPGVNNAFII 438

Query: 660 NSSSELALMYNDESVLENHHLAVAFKLLQN 749
           N+S E+AL YND+SVLENHH +  F+L  +
Sbjct: 439 NTSHEIALTYNDQSVLENHHASKTFQLFND 468


>UniRef50_Q54HY3 Cluster: Putative uncharacterized protein Pde4;
           n=2; Dictyostelium discoideum|Rep: Putative
           uncharacterized protein Pde4 - Dictyostelium discoideum
           AX4
          Length = 771

 Score = 89.0 bits (211), Expect = 1e-16
 Identities = 39/93 (41%), Positives = 58/93 (62%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++  Y   NP+HNS+HA DV  + N  +   +     T +E+ + + AA +HD  HPG+ 
Sbjct: 330 IESGYDSTNPYHNSIHATDVLHNLNYFIEK-SFGKFLTDIELFSMILAAIIHDFKHPGVN 388

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           N F +NS S LAL YND+S+LEN+HL  AF ++
Sbjct: 389 NHFQINSKSRLALKYNDKSILENYHLHQAFIIM 421


>UniRef50_Q8I6Y6 Cluster: CGMP-specific phosphodiesterase; n=3;
           Dictyostelium discoideum|Rep: CGMP-specific
           phosphodiesterase - Dictyostelium discoideum (Slime
           mold)
          Length = 522

 Score = 88.6 bits (210), Expect = 1e-16
 Identities = 37/89 (41%), Positives = 62/89 (69%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           R+NPFH+  HA  VTQ+  ++L    L  + +P+E  + + A+  HD+DHP L+N+F +N
Sbjct: 264 RNNPFHSFNHAIAVTQTIFLILLKTNLFNILSPIEKLSIIIASICHDLDHPALSNRFQIN 323

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749
             S +A++YN++SVLENHHL++   +L++
Sbjct: 324 MKSSIAVLYNNKSVLENHHLSICLGILES 352


>UniRef50_Q388U6 Cluster: 3', 5'-cyclic nucleotide
           phosphodiesterase, putative; n=2; Trypanosoma
           brucei|Rep: 3', 5'-cyclic nucleotide phosphodiesterase,
           putative - Trypanosoma brucei
          Length = 620

 Score = 88.6 bits (210), Expect = 1e-16
 Identities = 42/89 (47%), Positives = 59/89 (66%), Gaps = 2/89 (2%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           NP+HNS+HAADV   T+ LL+   L  +      +V AALFAA +HD +HPG+ N F + 
Sbjct: 368 NPYHNSMHAADVLHITHYLLSKGGLAELCKLNDRQVLAALFAAAIHDYNHPGINNNFSIL 427

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQN 749
           + +  A +YND SVLEN H+A  F+L++N
Sbjct: 428 TQTYNATLYNDRSVLENMHVASVFELMRN 456


>UniRef50_UPI000150A9A4 Cluster: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein; n=1; Tetrahymena
           thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein - Tetrahymena
           thermophila SB210
          Length = 929

 Score = 88.2 bits (209), Expect = 2e-16
 Identities = 48/117 (41%), Positives = 63/117 (53%), Gaps = 1/117 (0%)
 Frame = +3

Query: 399 HITGAVDYSSDTGAYFLGVCSYLKEHYI-RDNPFHNSLHAADVTQSTNVLLNTPALNAVF 575
           H+ G +D        FL     L+  Y  R NPFHN  HA  V+ +T   +N   L    
Sbjct: 625 HLAGFMDKLKIDKEVFLKFLQLLQHKYDKRQNPFHNFQHAIAVSHATYFFINAKFLARYL 684

Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
             LE    LF++  HDV H G TN F V + S+LA+ +NDESVLENHH +  FK++Q
Sbjct: 685 DYLEQFTLLFSSLGHDVSHTGRTNAFEVATLSKLAIKFNDESVLENHHSSTLFKIIQ 741


>UniRef50_Q01C40 Cluster: Cyclic GMP phosphodiesterase; n=1;
           Ostreococcus tauri|Rep: Cyclic GMP phosphodiesterase -
           Ostreococcus tauri
          Length = 674

 Score = 87.8 bits (208), Expect = 3e-16
 Identities = 42/94 (44%), Positives = 58/94 (61%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650
           E   RDNP+H   HA DV  +T + +         + LE+ + L AA VHD+DHPG+TN 
Sbjct: 302 ESMYRDNPYHCFKHAFDVAHTTYLYILAVKDQVEMSQLEIFSLLVAALVHDLDHPGVTNA 361

Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           +L+ +   +A+ YNDESVLEN HL+  F L QN+
Sbjct: 362 YLIATRDSIAMTYNDESVLENLHLSRFFTLCQNN 395


>UniRef50_Q5CXM2 Cluster: Membrane associated HD superfamily cyclic
            nucleotide phosphodiesterase domain containing protein;
            n=2; Cryptosporidium|Rep: Membrane associated HD
            superfamily cyclic nucleotide phosphodiesterase domain
            containing protein - Cryptosporidium parvum Iowa II
          Length = 1967

 Score = 87.8 bits (208), Expect = 3e-16
 Identities = 42/93 (45%), Positives = 53/93 (56%)
 Frame = +3

Query: 465  LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
            + + Y  D P+HN  HA  V Q   ++L    +  V   L     LFAA  HD+DHPG+ 
Sbjct: 1541 IHDSYNSDIPYHNIFHALQVVQVCYIILRNFGIMLVLNDLNKFILLFAALCHDIDHPGVN 1600

Query: 645  NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
            N FL  S+S+LAL YND S+LENHH    F LL
Sbjct: 1601 NCFLTISNSKLALKYNDNSILENHHCNYIFSLL 1633


>UniRef50_Q23AZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
           family protein; n=1; Tetrahymena thermophila SB210|Rep:
           3'5'-cyclic nucleotide phosphodiesterase family protein
           - Tetrahymena thermophila SB210
          Length = 577

 Score = 87.8 bits (208), Expect = 3e-16
 Identities = 40/102 (39%), Positives = 65/102 (63%), Gaps = 2/102 (1%)
 Frame = +3

Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALN--AVFTPLEVCAALFAACV 617
           F+ +   ++  Y RDNP+H+ LH+ DVTQ+ +  ++       A    +E  A  F+A +
Sbjct: 294 FINLSVRIQNGY-RDNPYHDRLHSFDVTQTIHFFISRCKFGELAKLKSMERAAMYFSAAI 352

Query: 618 HDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           HD DHPG  N FL+N+ + LAL +ND+SVLENHH++  ++++
Sbjct: 353 HDFDHPGYNNVFLINTQNILALKFNDQSVLENHHVSSVYEMI 394


>UniRef50_A0DIM1 Cluster: Chromosome undetermined scaffold_52, whole
           genome shotgun sequence; n=3; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_52,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 779

 Score = 87.4 bits (207), Expect = 3e-16
 Identities = 45/119 (37%), Positives = 61/119 (51%), Gaps = 1/119 (0%)
 Frame = +3

Query: 399 HITGAVDYSSDTGAYFLGVCSYLKEHY-IRDNPFHNSLHAADVTQSTNVLLNTPALNAVF 575
           H+   +D        F      ++E Y  R NPFHN  H   V  +   ++ + ++N  F
Sbjct: 494 HLCNFIDLYQINKEVFYQFTVIVQEKYSYRQNPFHNYDHGFTVAHACYYIIKSKSMNQYF 553

Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
                  AL +A  HD+DH G  N F     S+LAL YNDESVLENHH +V FK+LQ +
Sbjct: 554 DKFIQFTALLSALCHDIDHTGRNNHFESQKLSKLALRYNDESVLENHHASVMFKILQKE 612


>UniRef50_A0CU34 Cluster: Chromosome undetermined scaffold_28, whole
           genome shotgun sequence; n=4; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_28,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 903

 Score = 87.0 bits (206), Expect = 4e-16
 Identities = 43/101 (42%), Positives = 57/101 (56%), Gaps = 1/101 (0%)
 Frame = +3

Query: 444 FLGVCSYLKEHYIRD-NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVH 620
           F+   + LK  Y +  NPFHN  H  +V     +  + P     F   +  A   A   H
Sbjct: 629 FINFLTALKYKYNKTANPFHNFTHGVNVMHGCFLFTHHPKFGFCFNDQQRFAMTLAGLCH 688

Query: 621 DVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           DV HPG  N F VN+ ++LAL+YND+SVLENHH+AV +KLL
Sbjct: 689 DVGHPGTNNLFQVNTQTKLALLYNDKSVLENHHIAVTYKLL 729


>UniRef50_A4RUJ3 Cluster: Predicted protein; n=1; Ostreococcus
           lucimarinus CCE9901|Rep: Predicted protein -
           Ostreococcus lucimarinus CCE9901
          Length = 614

 Score = 86.2 bits (204), Expect = 8e-16
 Identities = 45/92 (48%), Positives = 55/92 (59%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650
           E   RDN +HN +HA DVTQ+   L+ T +L +   P+   A L AA  HDV HPG+ N 
Sbjct: 346 ERKYRDNDYHNRVHATDVTQAAAYLIET-SLESQIEPIHTFAMLVAAMSHDVGHPGVNNT 404

Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           FLVN  S  A  +ND SV EN HL  AF LL+
Sbjct: 405 FLVNCKSAEAERWNDVSVNENGHLFTAFSLLK 436


>UniRef50_A0EHP5 Cluster: Chromosome undetermined scaffold_97, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_97,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 908

 Score = 86.2 bits (204), Expect = 8e-16
 Identities = 42/97 (43%), Positives = 58/97 (59%), Gaps = 1/97 (1%)
 Frame = +3

Query: 465 LKEHY-IRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641
           ++E Y  R NPFHN  H   V  +   ++    L+      E  AA+ ++  HD+DH G 
Sbjct: 653 IEERYNSRRNPFHNFEHGFTVAHACYYMIKNKLLDEYLDQTEQFAAILSSLCHDIDHTGR 712

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           TN F V   S+LA+ YNDESVLENHH A+AFK++Q +
Sbjct: 713 TNGFEVARMSKLAVRYNDESVLENHHAAMAFKIMQRE 749


>UniRef50_Q2V2M6 Cluster: CGMP-specific phosphodiesterase; n=3;
           Plasmodium|Rep: CGMP-specific phosphodiesterase -
           Plasmodium falciparum
          Length = 884

 Score = 85.8 bits (203), Expect = 1e-15
 Identities = 42/92 (45%), Positives = 56/92 (60%), Gaps = 1/92 (1%)
 Frame = +3

Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPL-EVCAALFAACVHDVDHPGLTNQF 653
           Y  D P+H SLHAA V   +  +L    +N   + + E C  + + C HD  HPGL N F
Sbjct: 603 YYNDIPYHTSLHAAQVAHFSKSMLFMLDMNHKISAIDEFCLHISSLC-HDTGHPGLNNYF 661

Query: 654 LVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           L+NS + LAL YND SVLEN+H ++ FK L+N
Sbjct: 662 LINSENNLALTYNDNSVLENYHCSLLFKTLKN 693


>UniRef50_A5K0J4 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
           putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide
           phosphodiesterase, putative - Plasmodium vivax
          Length = 1001

 Score = 85.8 bits (203), Expect = 1e-15
 Identities = 45/96 (46%), Positives = 59/96 (61%), Gaps = 2/96 (2%)
 Frame = +3

Query: 465 LKEHYI-RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPL-EVCAALFAACVHDVDHPG 638
           LK H +  D P+HNSLHAA V   +  +L    +N     + E C  + + C HDV HPG
Sbjct: 715 LKMHSLYNDVPYHNSLHAAQVAHFSKSMLFLLDINHKIPAIDEFCLHVSSLC-HDVGHPG 773

Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           L N FL+NS + LAL YND SVLEN+H ++ FK L+
Sbjct: 774 LNNYFLINSENNLALTYNDNSVLENYHCSLVFKTLK 809


>UniRef50_A0CG66 Cluster: Chromosome undetermined scaffold_179, whole
            genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
            Chromosome undetermined scaffold_179, whole genome
            shotgun sequence - Paramecium tetraurelia
          Length = 1056

 Score = 85.8 bits (203), Expect = 1e-15
 Identities = 41/90 (45%), Positives = 52/90 (57%)
 Frame = +3

Query: 483  RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
            R NPFHN  H   V QS N L + P  +   + +   A + +   HD+ H G TNQF +N
Sbjct: 790  RKNPFHNFDHGITVMQSCNFLCSLPRAHEYISEIVYFATVISGLCHDISHTGRTNQFEIN 849

Query: 663  SSSELALMYNDESVLENHHLAVAFKLLQND 752
            S S+LA  Y D+S LENHH AV  KLL+ D
Sbjct: 850  SKSKLATRYLDKSPLENHHAAVTLKLLKQD 879


>UniRef50_A7AS42 Cluster: 3'5'-cyclic nucleotide phosphodiesterase,
           putative; n=1; Babesia bovis|Rep: 3'5'-cyclic nucleotide
           phosphodiesterase, putative - Babesia bovis
          Length = 485

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 42/98 (42%), Positives = 62/98 (63%)
 Frame = +3

Query: 453 VCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDH 632
           V + +++ Y+  NP+HN+LH A V   + VLL   +L    TPLE  A L AA  HD  H
Sbjct: 197 VLNSIQDVYL-PNPYHNALHGACVAHMSCVLLKALSLEQYLTPLEQFAYLIAALGHDAGH 255

Query: 633 PGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           PG TN FL ++ + LAL+YND S+LEN+H ++   +++
Sbjct: 256 PGKTNAFLRSTQNPLALIYNDASILENYHASLVCHIIR 293


>UniRef50_Q4KL87 Cluster: MGC116558 protein; n=2; Xenopus|Rep:
           MGC116558 protein - Xenopus laevis (African clawed frog)
          Length = 342

 Score = 85.0 bits (201), Expect = 2e-15
 Identities = 37/93 (39%), Positives = 62/93 (66%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           +++HY ++NPFHN  H   VTQ    +++   L    + +++   + AA  HD+DHPGL+
Sbjct: 81  VQKHY-QENPFHNFYHGFSVTQMMYCVISQCQLQEHLSHIDILTLMVAALCHDLDHPGLS 139

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           N + VN+ ++LA  Y+++S LENHH AVA+++L
Sbjct: 140 NSYQVNAQTDLARQYHNKSPLENHHWAVAWRIL 172


>UniRef50_Q4RR95 Cluster: Chromosome 14 SCAF15003, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 14 SCAF15003, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 456

 Score = 84.6 bits (200), Expect = 2e-15
 Identities = 45/110 (40%), Positives = 62/110 (56%), Gaps = 6/110 (5%)
 Frame = +3

Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHD 623
           FLG+   ++E Y   NP+HN++HAADVTQ+    L  P L    +PL+V   L AA  HD
Sbjct: 175 FLGM---VQEDYHSQNPYHNAVHAADVTQAMYCYLKEPKLAEQLSPLDVFLGLMAAAAHD 231

Query: 624 VDHPGLTNQFLVNSSSELALMY------NDESVLENHHLAVAFKLLQNDG 755
           VDHPG+   FL+ +   LA +Y       + SVLE+HH      +L+  G
Sbjct: 232 VDHPGVNQPFLIKTRHHLASLYQVHQSVQNTSVLESHHWRSTVGMLRESG 281


>UniRef50_A0EGK4 Cluster: Chromosome undetermined scaffold_95, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_95,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 756

 Score = 84.6 bits (200), Expect = 2e-15
 Identities = 39/89 (43%), Positives = 56/89 (62%)
 Frame = +3

Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665
           +N +HNSLHA DV  ST   LN   L+A     E    + ++  HD+ HPGL N F+  +
Sbjct: 480 NNLYHNSLHALDVANSTAFFLNN-GLDAQLDEFEFACLIVSSLAHDLGHPGLNNGFMTTN 538

Query: 666 SSELALMYNDESVLENHHLAVAFKLLQND 752
             +LAL+YND+SVLEN+H  + F++LQ +
Sbjct: 539 RCKLALLYNDQSVLENYHSFLLFQILQQE 567


>UniRef50_O89085 Cluster: cAMP-specific 3',5'-cyclic
           phosphodiesterase 4A; n=3; Euteleostomi|Rep:
           cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Cavia
           porcellus (Guinea pig)
          Length = 117

 Score = 83.8 bits (198), Expect = 4e-15
 Identities = 42/96 (43%), Positives = 64/96 (66%), Gaps = 4/96 (4%)
 Frame = +1

Query: 4   MLNKELSHFSDSSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGP 183
           MLN+EL+H S+ S+SGNQ+SEYI +TFLDKQ E+++PS  +++   + A ++   +   P
Sbjct: 13  MLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKDREPQEAPRQRPCQQLPP 72

Query: 184 AT----TMSQISGVKRTLTHTNSFTGERVPRYGVET 279
                  MSQI+GVKR L+H +      +PR+GV+T
Sbjct: 73  PVPHLQPMSQITGVKR-LSHNSGLNNASIPRFGVKT 107


>UniRef50_O76083 Cluster: High affinity cGMP-specific 3',5'-cyclic
           phosphodiesterase 9A; n=62; Eumetazoa|Rep: High affinity
           cGMP-specific 3',5'-cyclic phosphodiesterase 9A - Homo
           sapiens (Human)
          Length = 593

 Score = 82.6 bits (195), Expect = 9e-15
 Identities = 45/121 (37%), Positives = 64/121 (52%)
 Frame = +3

Query: 381 CRVHSVHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPA 560
           C  H  H  G V   S            + ++Y R+NPFHN  H   V Q    ++   +
Sbjct: 274 CLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNY-RNNPFHNFRHCFCVAQMMYSMVWLCS 332

Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           L   F+  ++   + AA  HD+DHPG  N + +N+ +ELA+ YND S LENHH AVAF++
Sbjct: 333 LQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI 392

Query: 741 L 743
           L
Sbjct: 393 L 393


>UniRef50_Q4RH59 Cluster: Chromosome undetermined SCAF15069, whole
           genome shotgun sequence; n=3; Euteleostomi|Rep:
           Chromosome undetermined SCAF15069, whole genome shotgun
           sequence - Tetraodon nigroviridis (Green puffer)
          Length = 695

 Score = 82.2 bits (194), Expect = 1e-14
 Identities = 45/110 (40%), Positives = 64/110 (58%), Gaps = 22/110 (20%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NP+HN +HAADVTQ+ + LL    +    T LE+ A +FAA VHD +H G TN F + +S
Sbjct: 282 NPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTS 341

Query: 669 ----------------------SELALMYNDESVLENHHLAVAFKLLQND 752
                                 S+ A++YND SVLE+HH++ A++LLQ+D
Sbjct: 342 SAKYTSCICPVQLQQDPKNEIKSDTAILYNDRSVLESHHVSAAYRLLQDD 391


>UniRef50_Q22CV4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Tetrahymena thermophila SB210|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Tetrahymena thermophila SB210
          Length = 1258

 Score = 81.8 bits (193), Expect = 2e-14
 Identities = 36/93 (38%), Positives = 55/93 (59%)
 Frame = +3

Query: 468  KEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647
            K++ I++N FHN  H   V QS  +L        V  P+++   + +   HDV H G TN
Sbjct: 884  KQYDIKNNDFHNFDHGVSVMQSCYMLSKCQRATQVLKPIDIFTVILSGLCHDVGHTGRTN 943

Query: 648  QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
             F ++  S+LA+ Y+D+SVLE HHLA  FK+++
Sbjct: 944  NFEISVQSKLAIRYHDKSVLEQHHLATTFKIMK 976


>UniRef50_A5JZK3 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
           putative; n=7; Plasmodium|Rep: 3',5'-cyclic-nucleotide
           phosphodiesterase, putative - Plasmodium vivax
          Length = 783

 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 40/93 (43%), Positives = 59/93 (63%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           +KE Y  + P+HN +HAA V +  N+L+N      +    E+ A L AA  HD+ H G T
Sbjct: 491 MKEGY-NNVPYHNCIHAAMVAEQCNILVNNLDTANILRDNEMAAFLLAALGHDIGHFGRT 549

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           N FL NSS+ L+++YND+S+LEN+H +  F +L
Sbjct: 550 NLFLKNSSNFLSVIYNDKSILENYHCSYLFHIL 582


>UniRef50_Q23RI8 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
           family protein; n=1; Tetrahymena thermophila SB210|Rep:
           3'5'-cyclic nucleotide phosphodiesterase family protein
           - Tetrahymena thermophila SB210
          Length = 807

 Score = 81.0 bits (191), Expect = 3e-14
 Identities = 37/92 (40%), Positives = 55/92 (59%), Gaps = 2/92 (2%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPGLTNQFL 656
           +DN +HN +HA DVTQ+ +  + +     +   + LE+     AA  HD  HPG  N +L
Sbjct: 538 QDNFYHNKMHAFDVTQTMHYFMQSLNFIGIADLSGLEIGLMYIAAAAHDYQHPGFNNPYL 597

Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           +N+ +ELA+ YND+S LENHH    F L+Q +
Sbjct: 598 INTRNELAIRYNDKSPLENHHAFSTFLLMQEE 629


>UniRef50_A7SVS5 Cluster: Predicted protein; n=1; Nematostella
           vectensis|Rep: Predicted protein - Nematostella
           vectensis
          Length = 496

 Score = 80.6 bits (190), Expect = 4e-14
 Identities = 41/93 (44%), Positives = 54/93 (58%)
 Frame = +3

Query: 474 HYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQF 653
           HY    PFHN  HA  VTQ    L+    +    T  ++   L +A  HD+DHPG  N +
Sbjct: 218 HY-NPTPFHNFRHAFCVTQMMYGLIWLTEIFNKITKQDLLIMLTSALCHDLDHPGYNNAY 276

Query: 654 LVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
            +N+ +ELAL YND S LENHH AVAF +++ D
Sbjct: 277 QINARTELALRYNDISPLENHHCAVAFDIMKQD 309


>UniRef50_UPI0000D577EC Cluster: PREDICTED: similar to CG32648-PA;
           n=2; Coelomata|Rep: PREDICTED: similar to CG32648-PA -
           Tribolium castaneum
          Length = 938

 Score = 79.8 bits (188), Expect = 7e-14
 Identities = 41/100 (41%), Positives = 58/100 (58%), Gaps = 2/100 (2%)
 Frame = +3

Query: 459 SYLKEHY--IRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDH 632
           ++L E Y    D PFHN  H   V Q    +  +  L +    LEV   L +   HD+DH
Sbjct: 232 NFLYEAYKNYNDVPFHNFRHCFCVAQMMYAISWSVDLPSKVGDLEVLILLTSCICHDLDH 291

Query: 633 PGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           PG  N + +N+ +ELA+ YND S LENHH +VAF++L+N+
Sbjct: 292 PGYNNIYQINAKTELAIRYNDISPLENHHCSVAFRILENE 331


>UniRef50_Q01CI7 Cluster: Cyclic GMP phosphodiesterase; n=1;
           Ostreococcus tauri|Rep: Cyclic GMP phosphodiesterase -
           Ostreococcus tauri
          Length = 526

 Score = 79.8 bits (188), Expect = 7e-14
 Identities = 40/88 (45%), Positives = 55/88 (62%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           RDN +HN +HAADVTQ+    + T +L     P+ + A L +A VHDV HPGL N +LV 
Sbjct: 259 RDNDYHNGVHAADVTQAAAYFIET-SLRDQIEPIHIFALLLSAVVHDVGHPGLNNAYLVA 317

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQ 746
             +++A  +N+ SV EN HL  A  LL+
Sbjct: 318 RQTDVAERWNNVSVNENGHLYTANTLLK 345


>UniRef50_A2DYU6 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1091

 Score = 79.4 bits (187), Expect = 9e-14
 Identities = 35/89 (39%), Positives = 52/89 (58%)
 Frame = +3

Query: 486  DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665
            D P+HN +HA DVT+     L T   + + +PLE  A L +A  HD +H G  N F + +
Sbjct: 817  DVPYHNWMHACDVTEYVAYELKTSGFDEMLSPLEKFALLLSAVCHDANHEGFNNIFNIKA 876

Query: 666  SSELALMYNDESVLENHHLAVAFKLLQND 752
             + L L++ D SV+E HHL V+  +L +D
Sbjct: 877  QTPLGLLFKDTSVMETHHLTVSIDILSDD 905


>UniRef50_Q9VYJ0 Cluster: CG32648-PA; n=3; Coelomata|Rep: CG32648-PA
           - Drosophila melanogaster (Fruit fly)
          Length = 963

 Score = 78.6 bits (185), Expect = 2e-13
 Identities = 40/94 (42%), Positives = 56/94 (59%), Gaps = 1/94 (1%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGLTN 647
           +HY  + PFHN  H   V Q    +     L +    LE C  L  +C+ HD+DHPG  N
Sbjct: 103 KHY-NEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLE-CLILLVSCICHDLDHPGYNN 160

Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
            + +N+ +ELAL YND S LENHH ++AF+LL++
Sbjct: 161 IYQINARTELALRYNDISPLENHHCSIAFRLLEH 194


>UniRef50_Q5C1P7 Cluster: SJCHGC07646 protein; n=1; Schistosoma
           japonicum|Rep: SJCHGC07646 protein - Schistosoma
           japonicum (Blood fluke)
          Length = 219

 Score = 78.6 bits (185), Expect = 2e-13
 Identities = 35/60 (58%), Positives = 46/60 (76%)
 Frame = +3

Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           + ++ T ++  A L AA VHDVDHPG TN FLVNS+  LA++YND +VLE+HH AVAF+L
Sbjct: 7   IRSICTNIDEVATLLAAIVHDVDHPGKTNPFLVNSNDPLAILYNDIAVLESHHAAVAFEL 66


>UniRef50_Q7PQX7 Cluster: ENSANGP00000010843; n=6; Coelomata|Rep:
           ENSANGP00000010843 - Anopheles gambiae str. PEST
          Length = 547

 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 40/93 (43%), Positives = 53/93 (56%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650
           +HY  D PFHN  H   V Q    +     L      LEV   L +   HD+DHPG  N 
Sbjct: 92  KHY-NDVPFHNYRHCFCVAQMMYTIAWHTNLVQRLGELEVLVLLVSCICHDLDHPGYNNI 150

Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           + +N+ +ELAL YND S LENHH ++AF+LL++
Sbjct: 151 YQINARTELALRYNDISPLENHHCSIAFRLLEH 183


>UniRef50_Q53I59 Cluster: Cyclic nucleotide specific
           phosphodiesterase; n=3; Trypanosoma cruzi|Rep: Cyclic
           nucleotide specific phosphodiesterase - Trypanosoma
           cruzi
          Length = 924

 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 41/92 (44%), Positives = 53/92 (57%), Gaps = 1/92 (1%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPA-LNAVFTPLEVCAALFAACVHDVDHPGLTN 647
           E+  R NP+HN++HAADV Q T  L++    L    TPLE  AA FAA  HDV HPG TN
Sbjct: 359 ENNYRPNPYHNAIHAADVLQGTFSLVSAAKPLMEHLTPLECKAAAFAALTHDVCHPGRTN 418

Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
            FL      ++  ++ +  LE  H   AF+LL
Sbjct: 419 AFLAAVQDPVSFKFSGKGTLEQLHTVTAFELL 450


>UniRef50_A0DF61 Cluster: Chromosome undetermined scaffold_49, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_49,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 768

 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 38/99 (38%), Positives = 57/99 (57%)
 Frame = +3

Query: 447 LGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDV 626
           LG  S   E   ++N +HNS+HA DV  ST   L    L+ +    +    L ++  HD+
Sbjct: 478 LGEFSVKIESLYQNNFYHNSMHAIDVANSTAFFLQN-GLSTLIDDFQATCLLISSLAHDI 536

Query: 627 DHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
            HPGL N F+  +   LAL++ND+SVLEN+H  + F++L
Sbjct: 537 GHPGLNNGFMTANRCRLALLFNDQSVLENYHSFLLFQVL 575


>UniRef50_A0CB76 Cluster: Chromosome undetermined scaffold_163,
           whole genome shotgun sequence; n=3; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_163,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 619

 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 36/92 (39%), Positives = 52/92 (56%), Gaps = 2/92 (2%)
 Frame = +3

Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAV--FTPLEVCAALFAACVHDVDHPGLTNQ 650
           Y +DN +HN +HA DVT +    +       +   T ++    L +A  HD DHPGL N 
Sbjct: 360 YHKDNLYHNVIHAFDVTHTVYFFIQKCNFKEIGKLTKIDYSILLMSAAAHDADHPGLNNI 419

Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           FL N+  +LA+ YND+S LE HH A  F+ ++
Sbjct: 420 FLSNTRHDLAMTYNDKSPLEQHHAATLFRYIR 451


>UniRef50_Q16VA1 Cluster: High-affinity cgmp-specific 3,5-cyclic
           phosphodiesterase; n=1; Aedes aegypti|Rep: High-affinity
           cgmp-specific 3,5-cyclic phosphodiesterase - Aedes
           aegypti (Yellowfever mosquito)
          Length = 1022

 Score = 77.8 bits (183), Expect = 3e-13
 Identities = 40/93 (43%), Positives = 53/93 (56%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQ 650
           +HY  D PFHN  H   V Q    +     L      LEV   L +   HD+DHPG  N 
Sbjct: 97  KHY-NDVPFHNYRHCFCVAQMMYAITWHTNLVQRLGELEVLILLVSCICHDLDHPGYNNI 155

Query: 651 FLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           + +N+ +ELAL YND S LENHH ++AF+LL++
Sbjct: 156 YQINARTELALRYNDISPLENHHCSIAFRLLEH 188


>UniRef50_UPI00006CB6E9 Cluster: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein; n=1; Tetrahymena
           thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein - Tetrahymena
           thermophila SB210
          Length = 699

 Score = 77.4 bits (182), Expect = 4e-13
 Identities = 37/88 (42%), Positives = 49/88 (55%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           R NPFHN  H   V     +L        +   +   A +F+   HDV H   TN F VN
Sbjct: 302 RGNPFHNFDHGITVMHGCYMLCCQTVAQTIIKEINEFALIFSGLCHDVSHTARTNLFEVN 361

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQ 746
           S S+LA+ Y+D+SVLE HH+AV FK+L+
Sbjct: 362 SMSKLAIRYHDKSVLEQHHIAVTFKILR 389


>UniRef50_A2D762 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=2; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1081

 Score = 77.4 bits (182), Expect = 4e-13
 Identities = 36/96 (37%), Positives = 55/96 (57%)
 Frame = +3

Query: 465  LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
            ++E Y  + P+HN +H  DV Q     ++T  L+ V+ PLE+ A   AA  HD  H GL 
Sbjct: 821  IREKY-NEVPYHNWMHCVDVCQYLAYEVSTAELDKVYKPLELLAMFVAAVCHDAGHEGLN 879

Query: 645  NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
            N + V + + L +++ D+SV+E HH  VA  LL  +
Sbjct: 880  NIYNVKAETPLGILFKDQSVMETHHCTVAISLLTKE 915


>UniRef50_A2DJF3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1006

 Score = 76.2 bits (179), Expect = 8e-13
 Identities = 33/87 (37%), Positives = 52/87 (59%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN  HA DVTQ  +  L    +  +  P+E+ A L AA  HDV+H G TN +   + +
Sbjct: 755  PYHNWRHAVDVTQFVSYQLVVSGVYKILKPIELYALLIAAICHDVNHDGFTNVYNEKAET 814

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L +++ ++SV+E HH  VA +++ ND
Sbjct: 815  PLGILFKNQSVMETHHCQVAIQVVSND 841


>UniRef50_Q6CHK1 Cluster: Similar to tr|Q8NJP9 Candida albicans High
           affinity cAMP phosphodiesterase; n=1; Yarrowia
           lipolytica|Rep: Similar to tr|Q8NJP9 Candida albicans
           High affinity cAMP phosphodiesterase - Yarrowia
           lipolytica (Candida lipolytica)
          Length = 626

 Score = 76.2 bits (179), Expect = 8e-13
 Identities = 43/112 (38%), Positives = 62/112 (55%), Gaps = 19/112 (16%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQST-------------------NVLLNTPALNAVFTPLE 587
           +++ Y  +NP+HN  HA DV Q+T                   N  +  P   AVFTP E
Sbjct: 349 MRDAYHHENPYHNFRHAIDVMQATFQFLIRLGCLPPPPFKRAPNCSMIPPIGPAVFTPAE 408

Query: 588 VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
               + AA  HD+ HPG+TN FLV+S S +A ++ND+SVLE++H  V  ++L
Sbjct: 409 SLVVIIAAIGHDISHPGVTNAFLVSSHSPMAQVFNDKSVLESYHACVLNRVL 460


>UniRef50_UPI00015B464B Cluster: PREDICTED: similar to
           ENSANGP00000010843; n=1; Nasonia vitripennis|Rep:
           PREDICTED: similar to ENSANGP00000010843 - Nasonia
           vitripennis
          Length = 801

 Score = 75.8 bits (178), Expect = 1e-12
 Identities = 35/85 (41%), Positives = 49/85 (57%)
 Frame = +3

Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
           PFHN  H   V Q   ++  +    +    LEV   + +   HD+DHPG  N + +N+ +
Sbjct: 545 PFHNFRHCFCVAQMLYIITGSVNTKSRIGDLEVLVLIVSCICHDLDHPGYNNIYQINART 604

Query: 672 ELALMYNDESVLENHHLAVAFKLLQ 746
           ELAL YND S LENHH +VAF +L+
Sbjct: 605 ELALRYNDISPLENHHCSVAFHILE 629


>UniRef50_UPI0000E48F4D Cluster: PREDICTED: similar to camp and
           camp-inhibited cgmp 3,5-cyclic phosphodiesterase; n=2;
           Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
           camp and camp-inhibited cgmp 3,5-cyclic
           phosphodiesterase - Strongylocentrotus purpuratus
          Length = 1197

 Score = 75.8 bits (178), Expect = 1e-12
 Identities = 42/98 (42%), Positives = 60/98 (61%), Gaps = 1/98 (1%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641
           ++++Y R  P+HN  HA  V  S   ++ T     VF PLE  A LF AC+ HD+DH G 
Sbjct: 24  VRKNY-RRVPYHNWTHAFSVAHSVYTMIMT-GQGQVFNPLEALA-LFVACLCHDLDHRGK 80

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
            N F+VN++S LA +Y+  S +E+HH  +   +LQNDG
Sbjct: 81  NNAFMVNTASPLASVYS-TSTMEHHHFNMTITILQNDG 117


>UniRef50_A2ERL4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=2; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1180

 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 31/87 (35%), Positives = 52/87 (59%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN  HA DVTQ     +    L  VFT  E+ + + AA  HD +H G TN + V + +
Sbjct: 811  PYHNWRHAVDVTQFVTYQIMISGLEKVFTKFELFSLVVAAICHDANHDGFTNIYNVKAET 870

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L ++Y ++SV+E HH ++A +++ ++
Sbjct: 871  PLGILYKNQSVMETHHCSIAIQIMSHE 897


>UniRef50_A0EF18 Cluster: Chromosome undetermined scaffold_92, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_92,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 929

 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 41/104 (39%), Positives = 57/104 (54%), Gaps = 4/104 (3%)
 Frame = +3

Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNT----PALNAVFTPLEVCAALFAA 611
           FLG   Y  +   R NPFHN  H  +V  S +V++N     P    +F  L   + + + 
Sbjct: 668 FLGELEYRYDK--RRNPFHNYNHGVNVMHSCHVIMNKMINQPQYKVLFDQLTKLSLILSG 725

Query: 612 CVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
             HDV H G TN F +N+ SE A+ Y+D++VLE +H A A KLL
Sbjct: 726 LCHDVGHTGRTNIFEINNFSEKAIRYHDKNVLEQYHAATALKLL 769


>UniRef50_A4VDP2 Cluster: Cyclic nucleotide phosphodiesterase; n=1;
            Tetrahymena thermophila SB210|Rep: Cyclic nucleotide
            phosphodiesterase - Tetrahymena thermophila SB210
          Length = 1074

 Score = 74.5 bits (175), Expect = 3e-12
 Identities = 38/95 (40%), Positives = 55/95 (57%), Gaps = 1/95 (1%)
 Frame = +3

Query: 465  LKEHYI-RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641
            L+E Y  R+NPFHN  H   V     ++      N     ++  + +F+   HDV H G 
Sbjct: 773  LREKYNKRENPFHNFDHGIMVMHGCFMIGCRTNANKYLNSIQEFSLVFSGLCHDVSHRGK 832

Query: 642  TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
            TN F VN+ S+LA+ Y+D+SVLE HH+A  FK+L+
Sbjct: 833  TNAFEVNTMSKLAIRYHDQSVLEQHHIAHTFKILR 867


>UniRef50_Q4SV96 Cluster: Chromosome 10 SCAF13771, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 10 SCAF13771, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 816

 Score = 69.3 bits (162), Expect(2) = 3e-12
 Identities = 33/61 (54%), Positives = 41/61 (67%)
 Frame = +3

Query: 558 ALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK 737
           +L  +   LE+ A   AA +HD DHPG TN FLV +S+  AL+YND SVLENHH A A+ 
Sbjct: 461 SLAGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQALLYNDRSVLENHHAASAWN 520

Query: 738 L 740
           L
Sbjct: 521 L 521



 Score = 25.0 bits (52), Expect(2) = 3e-12
 Identities = 11/29 (37%), Positives = 15/29 (51%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLNTP 557
           E+  R  P+HN +HA DV  +   L   P
Sbjct: 392 ENGYRVIPYHNRIHATDVLHAVWYLTTQP 420


>UniRef50_O96077 Cluster: EFPDE3; n=1; Ephydatia fluviatilis|Rep:
           EFPDE3 - Ephydatia fluviatilis
          Length = 1054

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 34/59 (57%), Positives = 42/59 (71%)
 Frame = +3

Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           + F+ LEV A   AA VHD DHPG TN FLV + S LA++YND +VLENHH A ++ LL
Sbjct: 661 SAFSILEVFATYMAAAVHDFDHPGRTNAFLVATKSPLAILYNDRAVLENHHCAASWDLL 719


>UniRef50_A7RXZ4 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
           Predicted protein - Nematostella vectensis
          Length = 367

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 37/65 (56%), Positives = 43/65 (66%)
 Frame = +3

Query: 558 ALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK 737
           AL  V   LE+ +   AA +HD DHPG TN FLV + S  AL+YND SVLENHH A AF 
Sbjct: 149 ALVDVIPLLELLSLYTAAAMHDYDHPGRTNAFLVATLSHQALLYNDRSVLENHHAAAAFT 208

Query: 738 LLQND 752
           LL +D
Sbjct: 209 LLMSD 213


>UniRef50_A7AR41 Cluster: 3'5'-cyclic nucleotide phosphodiesterase,
           putative; n=1; Babesia bovis|Rep: 3'5'-cyclic nucleotide
           phosphodiesterase, putative - Babesia bovis
          Length = 777

 Score = 73.3 bits (172), Expect = 6e-12
 Identities = 38/98 (38%), Positives = 52/98 (53%)
 Frame = +3

Query: 462 YLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641
           Y  E+  R+ P+HN +H A V Q    L +   L    + L+    + AA  HDV HPG 
Sbjct: 486 YRIENQYRNVPYHNKMHGAMVAQKVLCLASYTGLLEHLSILDEALLMVAALSHDVGHPGR 545

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
            N F V +   +A +YND SVLEN+H A A ++L   G
Sbjct: 546 NNAFFVRTHHPVAQLYNDTSVLENYHAASALRVLCTPG 583


>UniRef50_Q57ZK5 Cluster: 3', 5'-cyclic nucleotide
           phosphodiesterase, putative; n=1; Trypanosoma
           brucei|Rep: 3', 5'-cyclic nucleotide phosphodiesterase,
           putative - Trypanosoma brucei
          Length = 909

 Score = 72.5 bits (170), Expect = 1e-11
 Identities = 40/93 (43%), Positives = 54/93 (58%), Gaps = 1/93 (1%)
 Frame = +3

Query: 471 EHYIRDNPFHNSLHAADVTQSTNVLLN-TPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647
           E+  R NPFHN++ AADV Q+   L + T  L    T +E+ A +FAA   DV HPG TN
Sbjct: 357 ENNYRPNPFHNAVRAADVVQAVFSLASATKPLMRHVTLVELKALVFAAVALDVRHPGRTN 416

Query: 648 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           +FLV +   L   Y     LE  H+A AF+L++
Sbjct: 417 EFLVRTCDPLCYRYPGPGTLEQMHVATAFQLVE 449


>UniRef50_A2FKH2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1086

 Score = 72.5 bits (170), Expect = 1e-11
 Identities = 35/118 (29%), Positives = 59/118 (50%)
 Frame = +3

Query: 399  HITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFT 578
            H  G +     T   F    + L++ Y +  P+HN  HA DVTQ     L T   + + +
Sbjct: 780  HHFGVLQIFKVTNEKFFRFLTALRDKY-KKVPYHNWRHAVDVTQFVTYELITSGYDKILS 838

Query: 579  PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
              E+   L A   HD +H G TN + V + + L +++ ++SV+E HH A+A  ++  +
Sbjct: 839  SFELYGLLVACLCHDANHDGFTNVYNVKAETPLGILFKNQSVMETHHCAIAIDIISKE 896


>UniRef50_A2ENJ2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1087

 Score = 72.5 bits (170), Expect = 1e-11
 Identities = 31/87 (35%), Positives = 50/87 (57%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN  HA DVTQ     L T  + +  T  ++ A L AA  HD +H G TN + V + +
Sbjct: 831  PYHNWRHAVDVTQYVTFELETSGIVSKLTKFDIFALLVAAICHDANHDGFTNVYNVKAET 890

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L +++ ++SV+E HH A+A  ++  +
Sbjct: 891  PLGILFKNQSVMETHHCAMAISVISKE 917


>UniRef50_A2G2M9 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=2; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1136

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 37/112 (33%), Positives = 57/112 (50%)
 Frame = +3

Query: 408  GAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLE 587
            G ++    T   F      L+E Y  + P+HN +HA DV Q  +  +     + + T  E
Sbjct: 828  GLLERFQITNDLFFTFLYRLREAY-NEPPYHNWIHAIDVLQYISYQVRITNSHKILTQFE 886

Query: 588  VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
            + A   AA  HD  H GL N F VN+ + L +++ D+SV+E  H  VA ++L
Sbjct: 887  LLAVCVAALCHDAGHQGLNNAFNVNAETPLGILFKDQSVMETFHCTVAIRIL 938


>UniRef50_A2E4B2 Cluster: Response regulator receiver domain
           containing protein; n=1; Trichomonas vaginalis G3|Rep:
           Response regulator receiver domain containing protein -
           Trichomonas vaginalis G3
          Length = 637

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 36/86 (41%), Positives = 51/86 (59%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NPFHN   +    Q   ++L+         P E  A LFAA +HD+ HPG  N F + +S
Sbjct: 323 NPFHNFRRSIAGLQFATMILSK--YKERVPPFEAAAGLFAALLHDIGHPGTNNMFQIRTS 380

Query: 669 SELALMYNDESVLENHHLAVAFKLLQ 746
           S+LAL+YND+SVLE +  +V  +L+Q
Sbjct: 381 SQLALIYNDKSVLEMNSASVGARLVQ 406


>UniRef50_UPI0000D555D7 Cluster: PREDICTED: similar to
           phosphodiesterase 10A; n=4; Tribolium castaneum|Rep:
           PREDICTED: similar to phosphodiesterase 10A - Tribolium
           castaneum
          Length = 745

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 39/92 (42%), Positives = 53/92 (57%)
 Frame = +3

Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656
           + R NP+HN  HA +V     ++L        FT  E+ A + AA  HDVDHPG TN FL
Sbjct: 499 FYRRNPYHNFEHAFNVVHCMYLILKRNIKQ--FTETEIKALMIAALCHDVDHPGFTNNFL 556

Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQND 752
             S+++LA +Y + S LENH   VA  LL ++
Sbjct: 557 ELSNNDLANLY-ENSCLENHQYYVAMLLLDHN 587


>UniRef50_Q4FXD4 Cluster: Putative uncharacterized protein; n=3;
           Leishmania|Rep: Putative uncharacterized protein -
           Leishmania major strain Friedlin
          Length = 1084

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 38/88 (43%), Positives = 49/88 (55%), Gaps = 1/88 (1%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLL-NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLV 659
           R N +HN +HAADV Q    ++ + P L    T +E  A +FAA VHD+ HPG +  FL 
Sbjct: 607 RANQYHNRVHAADVLQGVYAMICSCPGLLPHMTTVEKRAVVFAAAVHDIRHPGRSEVFLK 666

Query: 660 NSSSELALMYNDESVLENHHLAVAFKLL 743
           N+     + YN   VLE  H A AF LL
Sbjct: 667 NTFDATYVHYNGLQVLEQMHTATAFHLL 694


>UniRef50_A5JZK2 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
            putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide
            phosphodiesterase, putative - Plasmodium vivax
          Length = 1164

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 37/97 (38%), Positives = 59/97 (60%), Gaps = 1/97 (1%)
 Frame = +3

Query: 459  SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPAL-NAVFTPLEVCAALFAACVHDVDHP 635
            S++++ Y  + P+HN++HA  VTQ    L     + + +   +++   +   C HDV HP
Sbjct: 860  SFVEKQY-NNVPYHNTIHATMVTQKFFCLSKKLGIYDHMEYKIKLVMFISGIC-HDVGHP 917

Query: 636  GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
            G  N F VNS   L+++YND SVLEN+H ++ FK+LQ
Sbjct: 918  GYNNLFFVNSLHPLSIIYNDISVLENYHASITFKILQ 954


>UniRef50_A0E2C5 Cluster: Chromosome undetermined scaffold_74, whole
            genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
            Chromosome undetermined scaffold_74, whole genome shotgun
            sequence - Paramecium tetraurelia
          Length = 975

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 42/112 (37%), Positives = 57/112 (50%), Gaps = 3/112 (2%)
 Frame = +3

Query: 417  DYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLL---NTPALNAVFTPLE 587
            D   DT   FL    Y  ++  + N FHN  H   V Q+ + +L   +  +  A+ +   
Sbjct: 699  DIPLDTLCQFLSEVEY--KYNKKKNVFHNYDHGVSVMQNVHAILLQLHQTSNAAIISTFN 756

Query: 588  VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
              A L +   HDV H G TN F +NS S LA+ Y+D SVLE HH A + KLL
Sbjct: 757  QFALLLSGLCHDVSHTGRTNTFEINSLSNLAIRYHDRSVLEQHHAAKSLKLL 808


>UniRef50_UPI00006CF33D Cluster: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein; n=1; Tetrahymena
           thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein - Tetrahymena
           thermophila SB210
          Length = 354

 Score = 70.9 bits (166), Expect = 3e-11
 Identities = 41/120 (34%), Positives = 57/120 (47%)
 Frame = +3

Query: 396 VHITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVF 575
           + + G +  SS+    FL   S   ++  R NPFHN  H   V      ++     N   
Sbjct: 64  IDLLGILGQSSNKFQNFLVQLS--NKYDYRGNPFHNFDHGITVAHGIYYIIKQGITNKHL 121

Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
             LE  + LF+A  HDVDH G +N +  NS SEL  +Y +ES LE HH A   ++    G
Sbjct: 122 NQLEKFSLLFSALCHDVDHTGHSNAYETNSKSELFTLYGNESPLEKHHYAQTIQIADQCG 181


>UniRef50_Q4T098 Cluster: Chromosome undetermined SCAF11274, whole
           genome shotgun sequence; n=4; Tetraodontidae|Rep:
           Chromosome undetermined SCAF11274, whole genome shotgun
           sequence - Tetraodon nigroviridis (Green puffer)
          Length = 601

 Score = 70.9 bits (166), Expect = 3e-11
 Identities = 27/59 (45%), Positives = 43/59 (72%)
 Frame = +3

Query: 576 TPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           T LE+ A +FAA +HD +H G TN F + + S+++L+YND +V ENHH++  ++LLQ +
Sbjct: 262 TELEIFATIFAAAIHDYEHTGTTNNFHIQTRSDISLLYNDHAVQENHHVSAVYRLLQTN 320


>UniRef50_Q8IKD3 Cluster: Cyclic nucleotide phosphodiesterase,
           putative; n=1; Plasmodium falciparum 3D7|Rep: Cyclic
           nucleotide phosphodiesterase, putative - Plasmodium
           falciparum (isolate 3D7)
          Length = 813

 Score = 70.9 bits (166), Expect = 3e-11
 Identities = 31/86 (36%), Positives = 49/86 (56%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NP+HN+ H A V   +  L +    ++      +   L A+  HDV HPG TN +L  ++
Sbjct: 454 NPYHNANHGATVCHLSKCLAHITDYDSYLNNTYMICYLIASIAHDVGHPGKTNSYLSETN 513

Query: 669 SELALMYNDESVLENHHLAVAFKLLQ 746
             L++ YND S+LEN+H ++ F +LQ
Sbjct: 514 HILSIRYNDMSILENYHCSITFSILQ 539


>UniRef50_A2F9J4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1119

 Score = 70.9 bits (166), Expect = 3e-11
 Identities = 39/97 (40%), Positives = 51/97 (52%)
 Frame = +3

Query: 453  VCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDH 632
            +CS L+  Y    P+HN  HA DV Q     +    L      LE+ A L AA  HDVDH
Sbjct: 853  ICS-LRSCY-NVTPYHNWTHACDVMQFVFSCIIRGHLRQYLNDLEIFALLLAAICHDVDH 910

Query: 633  PGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
             GL N F   + + L ++Y D+ V+E HH A A +LL
Sbjct: 911  HGLNNAFHKKARTPLGILYEDKPVMEMHHCATAIRLL 947


>UniRef50_O00408 Cluster: cGMP-dependent 3',5'-cyclic
           phosphodiesterase; n=47; Eumetazoa|Rep: cGMP-dependent
           3',5'-cyclic phosphodiesterase - Homo sapiens (Human)
          Length = 941

 Score = 70.9 bits (166), Expect = 3e-11
 Identities = 38/101 (37%), Positives = 52/101 (51%), Gaps = 1/101 (0%)
 Frame = +3

Query: 456 CSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635
           C  +K+ Y RD P+HN +HA  V+    +L     L      +E+ A   +   HD+DH 
Sbjct: 643 CLMVKKGY-RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHR 701

Query: 636 GLTNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755
           G  N F V S S LA +Y+ E SV+E HH A A  +L   G
Sbjct: 702 GTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHG 742


>UniRef50_A2E8N2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1103

 Score = 70.5 bits (165), Expect = 4e-11
 Identities = 33/87 (37%), Positives = 47/87 (54%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN  HA DVTQ     L    L+ VF+P E+ A L A   HD +H G  NQ+   +  
Sbjct: 821  PYHNWTHAVDVTQFMVYQLEKAELSKVFSPFEILAILVATICHDANHNGFNNQYNEKAQL 880

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L +++ D SVLE +H  VA  ++  +
Sbjct: 881  PLGILFKDMSVLEVYHCTVAIGIISKE 907


>UniRef50_A2DG30 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1090

 Score = 70.5 bits (165), Expect = 4e-11
 Identities = 32/90 (35%), Positives = 51/90 (56%)
 Frame = +3

Query: 483  RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
            R  P+HN  HA DV Q T   ++   L+     +E+ A L AA  HD++H G TN + V 
Sbjct: 774  RPVPYHNWAHAVDVLQFTAYQVHISHLDEKIPKVELFALLVAAICHDLNHDGFTNDYNVK 833

Query: 663  SSSELALMYNDESVLENHHLAVAFKLLQND 752
            + + L +++ ++SV+E HH  V   ++ ND
Sbjct: 834  AETPLGILFKNQSVMEMHHCEVTIDIMSND 863


>UniRef50_UPI000065CC62 Cluster: cGMP-inhibited 3',5'-cyclic
           phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited
           phosphodiesterase A) (CGI-PDE A).; n=1; Takifugu
           rubripes|Rep: cGMP-inhibited 3',5'-cyclic
           phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited
           phosphodiesterase A) (CGI-PDE A). - Takifugu rubripes
          Length = 706

 Score = 70.1 bits (164), Expect = 5e-11
 Identities = 32/63 (50%), Positives = 42/63 (66%)
 Frame = +3

Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           L+ +   LE+ A   AA +HD DHPG TN FLV +S+  A++YND SVLENHH A A+ L
Sbjct: 378 LSGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNL 437

Query: 741 LQN 749
             +
Sbjct: 438 FMS 440


>UniRef50_Q4RSB8 Cluster: Chromosome 13 SCAF15000, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 13 SCAF15000, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 737

 Score = 70.1 bits (164), Expect = 5e-11
 Identities = 32/63 (50%), Positives = 42/63 (66%)
 Frame = +3

Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           L+ +   LE+ A   AA +HD DHPG TN FLV +S+  A++YND SVLENHH A A+ L
Sbjct: 415 LSGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNL 474

Query: 741 LQN 749
             +
Sbjct: 475 FMS 477


>UniRef50_Q8I0P7 Cluster: Probable 3',5'-cyclic phosphodiesterase
           pde-3; n=4; Caenorhabditis|Rep: Probable 3',5'-cyclic
           phosphodiesterase pde-3 - Caenorhabditis elegans
          Length = 578

 Score = 70.1 bits (164), Expect = 5e-11
 Identities = 38/96 (39%), Positives = 51/96 (53%)
 Frame = +3

Query: 456 CSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635
           C YL  H +R   F        V    +      ++ +  + LE+ A   AA +HD DHP
Sbjct: 268 CYYLSAHPVRST-FLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAMHDYDHP 326

Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           G TN FLV    + A++YND SVLENHH A ++KLL
Sbjct: 327 GRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLL 362


>UniRef50_A5K353 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
           putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide
           phosphodiesterase, putative - Plasmodium vivax
          Length = 803

 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 31/86 (36%), Positives = 48/86 (55%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NP+HN+ H A V   +  L +    +       +   L A+  HDV HPG TN +L  ++
Sbjct: 433 NPYHNANHGATVCHLSKCLAHITDFDKSLNNTYMICYLIASIAHDVGHPGKTNAYLSETN 492

Query: 669 SELALMYNDESVLENHHLAVAFKLLQ 746
             L++ YND S+LEN+H ++ F +LQ
Sbjct: 493 HILSIRYNDMSILENYHCSITFSILQ 518


>UniRef50_A2FBN7 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1090

 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 30/84 (35%), Positives = 47/84 (55%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN +HA DV Q  +  +    L  +FT  E+ A L AA  HD  H G  N + V + +
Sbjct: 831  PYHNWIHAVDVVQYVSYEMRLGELENIFTKFEIFAMLVAAVCHDAGHSGFNNIYNVKAET 890

Query: 672  ELALMYNDESVLENHHLAVAFKLL 743
             L +++ ++SV+E +H  VA  +L
Sbjct: 891  PLGILFKEQSVMETYHCTVAISIL 914


>UniRef50_A0E1V7 Cluster: Chromosome undetermined scaffold_74, whole
            genome shotgun sequence; n=3; Paramecium tetraurelia|Rep:
            Chromosome undetermined scaffold_74, whole genome shotgun
            sequence - Paramecium tetraurelia
          Length = 1007

 Score = 69.7 bits (163), Expect = 7e-11
 Identities = 37/98 (37%), Positives = 55/98 (56%), Gaps = 4/98 (4%)
 Frame = +3

Query: 471  EHYIRDNPFHNSLHAADVTQSTNVLLN--TPALNAVF--TPLEVCAALFAACVHDVDHPG 638
            ++ + +NP+HN  H   V Q+ N  +   T  L+  F     + C  L A C HDV H G
Sbjct: 739  QYNMNNNPYHNFDHGVAVMQAVNCFIKSLTNQLDQQFFNNITKFCLLLSALC-HDVAHTG 797

Query: 639  LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
             TN +  NS S+LA+ Y+D+ +LE HH A   K+L++D
Sbjct: 798  KTNAYEANSISQLAIRYHDKVILEQHHAATTIKILRDD 835


>UniRef50_A2EIP4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=2; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1334

 Score = 69.3 bits (162), Expect = 9e-11
 Identities = 34/95 (35%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
 Frame = +3

Query: 480  IRDN----PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647
            IRDN    P+HN  HA DV Q     +     N + +  E+ A L A   HDV H G TN
Sbjct: 1075 IRDNYKKVPYHNWRHAVDVMQFVAYQILVSGCNTILSKFEIFAILVACLCHDVGHDGFTN 1134

Query: 648  QFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
             F   + + L L++ ++SV+E HH +V+  +L  +
Sbjct: 1135 AFNEKAETPLGLLFKNQSVMETHHCSVSIGILSKE 1169


>UniRef50_Q4N6H0 Cluster: Putative uncharacterized protein; n=1;
           Theileria parva|Rep: Putative uncharacterized protein -
           Theileria parva
          Length = 840

 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 30/84 (35%), Positives = 48/84 (57%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN +H   V Q    L N   + +  + ++    + +   HD+ HPGLTN F +NS  +
Sbjct: 606 YHNQMHGVFVCQKLLCLSNFTNVYSRLSVIDRTILIISGLCHDIGHPGLTNAFFINSGHQ 665

Query: 675 LALMYNDESVLENHHLAVAFKLLQ 746
           LA ++ND+SVLEN H  + F +L+
Sbjct: 666 LAHLFNDKSVLENFHCCLTFNVLR 689


>UniRef50_A0CZB5 Cluster: Chromosome undetermined scaffold_32, whole
            genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
            Chromosome undetermined scaffold_32, whole genome shotgun
            sequence - Paramecium tetraurelia
          Length = 1270

 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 1/98 (1%)
 Frame = +3

Query: 459  SYLKEHYIR-DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635
            S L++ Y + +N FHN  H   V QS + +L               A + +   HDV H 
Sbjct: 994  SVLQQKYNKKNNSFHNYDHGISVMQSAHFMLQCEKAKQFIDDFRRMATIISGLCHDVSHT 1053

Query: 636  GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
            G TN F++NS S+LA  Y+D S LE HH A    +L++
Sbjct: 1054 GRTNVFMINSQSKLATRYHDSSPLEQHHAATTIFMLKD 1091


>UniRef50_O94034 Cluster: Nucleotide phosphodiesterase; n=4;
           Saccharomycetales|Rep: Nucleotide phosphodiesterase -
           Candida albicans (Yeast)
          Length = 571

 Score = 59.7 bits (138), Expect(2) = 1e-10
 Identities = 26/60 (43%), Positives = 37/60 (61%)
 Frame = +3

Query: 549 NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728
           N+    A   P++    L AA  HDV HPG TN F++  S+  AL+YND SVLE++H ++
Sbjct: 326 NSSEEKASLNPIQTLGLLVAALGHDVGHPGTTNDFMIKFSAPTALLYNDRSVLESYHASL 385



 Score = 29.1 bits (62), Expect(2) = 1e-10
 Identities = 11/23 (47%), Positives = 15/23 (65%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQS 533
           +++ Y   NPFHN  HA DV Q+
Sbjct: 263 VRDTYKNGNPFHNFRHAVDVLQA 285


>UniRef50_A2DF08 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1040

 Score = 68.5 bits (160), Expect = 2e-10
 Identities = 32/87 (36%), Positives = 48/87 (55%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN  HA DVTQ     L     + V T  EV A L +A  HD +H G TN + V + +
Sbjct: 785  PYHNWRHAVDVTQFVVYELLESGCDKVLTKFEVFALLVSAVCHDANHDGFTNVYNVKAET 844

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L +++ ++SV+E HH  VA  ++  +
Sbjct: 845  PLGILFKNQSVMETHHCQVAIGVISKE 871


>UniRef50_Q14432 Cluster: cGMP-inhibited 3',5'-cyclic
           phosphodiesterase A; n=27; Euteleostomi|Rep:
           cGMP-inhibited 3',5'-cyclic phosphodiesterase A - Homo
           sapiens (Human)
          Length = 1141

 Score = 68.5 bits (160), Expect = 2e-10
 Identities = 31/56 (55%), Positives = 39/56 (69%)
 Frame = +3

Query: 582 LEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           LE+ A   AA +HD DHPG TN FLV +S+  A++YND SVLENHH A A+ L  +
Sbjct: 824 LELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMS 879


>UniRef50_UPI0000D8B81A Cluster: UPI0000D8B81A related cluster; n=1;
           Mus musculus|Rep: UPI0000D8B81A UniRef100 entry - Mus
           musculus
          Length = 746

 Score = 67.7 bits (158), Expect = 3e-10
 Identities = 31/87 (35%), Positives = 45/87 (51%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  HA +V Q    +L T     + T +E+ A +     HD+DH G  N F   S S 
Sbjct: 495 YHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSA 554

Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755
           LA +Y   + LE+HH   A  +LQ++G
Sbjct: 555 LAQLYGTSATLEHHHFNHAVMILQSEG 581


>UniRef50_O96076 Cluster: EFPDE2; n=1; Ephydatia fluviatilis|Rep:
           EFPDE2 - Ephydatia fluviatilis
          Length = 819

 Score = 67.7 bits (158), Expect = 3e-10
 Identities = 41/99 (41%), Positives = 56/99 (56%), Gaps = 2/99 (2%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641
           +K+ Y RD P+HN +HA  V      L    +  +    LEV  ALF +C+ HD+DH G 
Sbjct: 554 VKKGY-RDPPYHNWMHAFSVAHFLYALYCCSSKLSCLDDLEV-LALFVSCLCHDIDHRGT 611

Query: 642 TNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755
            N F V S+S LA +Y+ E SV+E HHLA    +L + G
Sbjct: 612 NNAFQVCSNSTLACLYSSEGSVMERHHLAQTLCILNSPG 650


>UniRef50_A2FQ29 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=2; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1175

 Score = 67.7 bits (158), Expect = 3e-10
 Identities = 27/87 (31%), Positives = 47/87 (54%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN LHA DV Q    LL    L +  +  E+   + +   HD++H G +N +   + +
Sbjct: 904  PYHNFLHAVDVMQFAVYLLKKSKLESEISKFEILGLIISCLCHDINHDGFSNSYNEKAQT 963

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L ++Y ++SVLE HH +V   ++  +
Sbjct: 964  PLGILYKNQSVLETHHCSVCISIMTRE 990


>UniRef50_A2DNV4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1023

 Score = 67.7 bits (158), Expect = 3e-10
 Identities = 32/107 (29%), Positives = 55/107 (51%)
 Frame = +3

Query: 432  TGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAA 611
            T   F    + + E Y +  P+HN  HA DVTQ     +    ++ + T  E+   L A 
Sbjct: 756  TNEKFFSFLTEVSESYNKV-PYHNRRHAVDVTQFVAYEIIIGKIDKILTKEELFCLLIAC 814

Query: 612  CVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
              HD++H G TN + V + + L +++ ++SV+E HH  V   ++ N+
Sbjct: 815  ICHDINHDGFTNVYNVKAETPLGILFKNQSVMETHHCEVTIGIMTNE 861


>UniRef50_P30645 Cluster: Probable 3',5'-cyclic phosphodiesterase
           pde-2; n=5; Eumetazoa|Rep: Probable 3',5'-cyclic
           phosphodiesterase pde-2 - Caenorhabditis elegans
          Length = 859

 Score = 67.3 bits (157), Expect = 4e-10
 Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           R  P+HN  HA  VT    + L T A+    + +E  + L A   HD+DH G TN F + 
Sbjct: 417 RPVPYHNWSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQ 476

Query: 663 S--SSELALMYNDE-SVLENHHLAVAFKLLQND 752
           S   + L+++Y+ E SVLE HH A   KLLQ +
Sbjct: 477 SLQKTPLSVLYSTEGSVLERHHFAQTIKLLQQE 509


>UniRef50_Q9HCR9 Cluster: Dual 3',5'-cyclic-AMP and -GMP
           phosphodiesterase 11A; n=42; Eumetazoa|Rep: Dual
           3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo
           sapiens (Human)
          Length = 934

 Score = 67.3 bits (157), Expect = 4e-10
 Identities = 31/87 (35%), Positives = 45/87 (51%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  HA +V Q    +L T     + T +E+ A +     HD+DH G  N F   S S 
Sbjct: 663 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 722

Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755
           LA +Y   + LE+HH   A  +LQ++G
Sbjct: 723 LAQLYGTSATLEHHHFNHAVMILQSEG 749


>UniRef50_UPI00006A17C5 Cluster: cGMP-inhibited 3',5'-cyclic
           phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited
           phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).;
           n=1; Xenopus tropicalis|Rep: cGMP-inhibited 3',5'-cyclic
           phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited
           phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1). -
           Xenopus tropicalis
          Length = 959

 Score = 66.9 bits (156), Expect = 5e-10
 Identities = 31/60 (51%), Positives = 41/60 (68%)
 Frame = +3

Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           L++    LE+ A   AA +HD DHPG TN FLV +++  A++YND SVLENHH A A+ L
Sbjct: 696 LSSNIPALELMALFVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL 755


>UniRef50_Q4SI77 Cluster: Chromosome 5 SCAF14581, whole genome
           shotgun sequence; n=3; Clupeocephala|Rep: Chromosome 5
           SCAF14581, whole genome shotgun sequence - Tetraodon
           nigroviridis (Green puffer)
          Length = 750

 Score = 66.9 bits (156), Expect = 5e-10
 Identities = 30/53 (56%), Positives = 38/53 (71%)
 Frame = +3

Query: 582 LEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           LE+ A   AA +HD DHPG TN FLV +++  A++YND SVLENHH A A+ L
Sbjct: 442 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAAAAWSL 494


>UniRef50_Q7QRM3 Cluster: GLP_481_5888_1773; n=1; Giardia lamblia ATCC
            50803|Rep: GLP_481_5888_1773 - Giardia lamblia ATCC 50803
          Length = 1371

 Score = 56.4 bits (130), Expect(2) = 6e-10
 Identities = 23/67 (34%), Positives = 41/67 (61%)
 Frame = +3

Query: 543  LLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHL 722
            L+      A+  P++  A LF +  HD+ H G+ N F +N+ + LAL+YNDE+ LE+ H 
Sbjct: 1118 LITEQPRQALIRPVDFLALLFGSLCHDLGHTGIDNLFCINTENALALLYNDEAPLEHAHA 1177

Query: 723  AVAFKLL 743
             +++ ++
Sbjct: 1178 TLSWHII 1184



 Score = 30.3 bits (65), Expect(2) = 6e-10
 Identities = 18/51 (35%), Positives = 24/51 (47%)
 Frame = +3

Query: 402  ITGAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNT 554
            + G   Y S      L V   L+  Y     +HN LHAADV Q +  +L+T
Sbjct: 1037 LLGITTYFSIHDNVLLAVLIELESSYT-STLYHNKLHAADVAQMSMYMLST 1086


>UniRef50_Q3KVL8 Cluster: High-affinity phosphodiesterase; n=4;
           Eukaryota|Rep: High-affinity phosphodiesterase -
           Cryptococcus neoformans var. neoformans
          Length = 555

 Score = 56.8 bits (131), Expect(2) = 6e-10
 Identities = 29/68 (42%), Positives = 40/68 (58%)
 Frame = +3

Query: 552 TPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVA 731
           T     +  P ++ A L AA  HDV HPGL+N F+V  S  L+ +Y D+SVLEN H  + 
Sbjct: 307 TKRAREIMRPQDILAVLIAAMGHDVGHPGLSNAFMV--SCPLSQVYEDKSVLENMHCMLV 364

Query: 732 FKLLQNDG 755
            +LL+  G
Sbjct: 365 VQLLRKYG 372



 Score = 29.9 bits (64), Expect(2) = 6e-10
 Identities = 12/24 (50%), Positives = 15/24 (62%)
 Frame = +3

Query: 477 YIRDNPFHNSLHAADVTQSTNVLL 548
           Y   NP+HN +HA DV Q+T   L
Sbjct: 248 YHAPNPYHNYVHALDVLQATYTFL 271


>UniRef50_Q4RHZ1 Cluster: Chromosome 8 SCAF15044, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 8 SCAF15044, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 884

 Score = 66.5 bits (155), Expect = 7e-10
 Identities = 32/96 (33%), Positives = 53/96 (55%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           ++++Y R   +HN  HA +V+Q   +++ T +   V +  EV A +     HD+DH G  
Sbjct: 635 VRKNY-RTVAYHNWRHAFNVSQCMFIMITTASFQDVLSDAEVLALMVGCLCHDLDHRGTN 693

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           N F   + S LAL+Y   + LE+HH   A  +LQ++
Sbjct: 694 NAFQAKTGSALALLYGTSATLEHHHFNHAVMILQSE 729


>UniRef50_A2EY05 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
           family protein; n=1; Trichomonas vaginalis G3|Rep:
           3'5'-cyclic nucleotide phosphodiesterase family protein
           - Trichomonas vaginalis G3
          Length = 922

 Score = 66.5 bits (155), Expect = 7e-10
 Identities = 35/115 (30%), Positives = 57/115 (49%)
 Frame = +3

Query: 408 GAVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLE 587
           G ++    + + FL     L+ +Y  + P+HN  HA DV Q  +  +     +      E
Sbjct: 644 GILEKFQISSSLFLKFLLKLRRNY-NNPPYHNWTHAIDVLQYVSYEIKLTNSHNHLKSQE 702

Query: 588 VCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           + + L AA  HDV H G  N + +N  +   +++ D SV+E  H A+A K+LQ D
Sbjct: 703 LLSVLVAALCHDVGHQGFNNAYNINVKTPFGILFKDTSVMETFHCAMAIKILQED 757


>UniRef50_Q13370 Cluster: cGMP-inhibited 3',5'-cyclic
           phosphodiesterase B; n=26; Euteleostomi|Rep:
           cGMP-inhibited 3',5'-cyclic phosphodiesterase B - Homo
           sapiens (Human)
          Length = 1112

 Score = 66.5 bits (155), Expect = 7e-10
 Identities = 31/60 (51%), Positives = 41/60 (68%)
 Frame = +3

Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           L++    LE+ A   AA +HD DHPG TN FLV +++  A++YND SVLENHH A A+ L
Sbjct: 802 LSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL 861


>UniRef50_UPI0001554EBF Cluster: PREDICTED: similar to cyclic
           nucleotide phophodiesterase, partial; n=1;
           Ornithorhynchus anatinus|Rep: PREDICTED: similar to
           cyclic nucleotide phophodiesterase, partial -
           Ornithorhynchus anatinus
          Length = 340

 Score = 66.1 bits (154), Expect = 9e-10
 Identities = 30/53 (56%), Positives = 38/53 (71%)
 Frame = +3

Query: 582 LEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           LE+ A   AA +HD DHPG TN FLV +++  A++YND SVLENHH A A+ L
Sbjct: 187 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL 239



 Score = 39.1 bits (87), Expect = 0.12
 Identities = 22/48 (45%), Positives = 27/48 (56%), Gaps = 7/48 (14%)
 Frame = +3

Query: 582 LEVCAALFAACVHDVDHPGLTNQFLV-------NSSSELALMYNDESV 704
           LE+ A   AA +HD DHPG TN FLV       N+SS   L Y+D  +
Sbjct: 110 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQQNTSSPAYLDYSDSGI 157


>UniRef50_A3FQ29 Cluster: CGMP phosphodiesterase A4; n=2;
           Cryptosporidium|Rep: CGMP phosphodiesterase A4 -
           Cryptosporidium parvum Iowa II
          Length = 997

 Score = 66.1 bits (154), Expect = 9e-10
 Identities = 36/96 (37%), Positives = 53/96 (55%), Gaps = 2/96 (2%)
 Frame = +3

Query: 462 YLKEHYIR--DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHP 635
           + +E  IR  +N +HN LH  +V      L     L +    +E  A++ A+  HDV H 
Sbjct: 711 FFRELNIRYLNNKYHNELHGTNVCHLAICLSRATGLWSHLDTVERLASVIASLGHDVGHI 770

Query: 636 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           G T+ FLVNS   LA+ YND SVLE  H ++ F+++
Sbjct: 771 GRTSNFLVNSRHMLAINYNDRSVLEMFHASLTFRII 806


>UniRef50_A2DBZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1126

 Score = 66.1 bits (154), Expect = 9e-10
 Identities = 34/99 (34%), Positives = 51/99 (51%)
 Frame = +3

Query: 459  SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPG 638
            ++ +E+Y  +  FHN  HA D TQ   V L            +  A L A+ +HDV+H G
Sbjct: 878  TFTRENYNENLKFHNFEHALDFTQFVFVCLTRNKFGNCMNVDQKAALLCASLLHDVNHDG 937

Query: 639  LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
                FL  +SS L  +Y  ES LE HH++ A ++++  G
Sbjct: 938  TNTLFLNQTSSYLVDLYGKESTLERHHVSEALRIVEKSG 976


>UniRef50_UPI00015B4531 Cluster: PREDICTED: similar to cyclic GMP
           stimulated phosphodiesterase; n=1; Nasonia
           vitripennis|Rep: PREDICTED: similar to cyclic GMP
           stimulated phosphodiesterase - Nasonia vitripennis
          Length = 1684

 Score = 65.3 bits (152), Expect = 2e-09
 Identities = 36/101 (35%), Positives = 53/101 (52%), Gaps = 3/101 (2%)
 Frame = +3

Query: 462 YLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHP 635
           Y+K+ Y RD P+HN +HA  V     +L+    L  +   T L+    L +   HD+DH 
Sbjct: 423 YVKKGY-RDAPYHNWMHAFSVAHFAYLLMKNLNLVRDGYMTSLQALVFLVSCLCHDIDHR 481

Query: 636 GLTNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755
           G  N F     + LA +Y+ E SV+E HHLA +  +L  +G
Sbjct: 482 GTNNSFQTKCGTILASLYSSEGSVMERHHLAQSMCILNTEG 522


>UniRef50_Q6S996 Cluster: Class I phosphodiesterase PDEB1; n=21;
           Trypanosomatidae|Rep: Class I phosphodiesterase PDEB1 -
           Leishmania major
          Length = 940

 Score = 65.3 bits (152), Expect = 2e-09
 Identities = 32/89 (35%), Positives = 50/89 (56%), Gaps = 3/89 (3%)
 Frame = +3

Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
           P+HN  H  DV Q+ +  L T   + + T LE    L  A VHD+DH G+ N F + + S
Sbjct: 679 PYHNFYHVVDVCQTLHTYLYTGKASELLTELECYVLLVTALVHDLDHMGVNNSFYLKTDS 738

Query: 672 ELALMYN---DESVLENHHLAVAFKLLQN 749
            L ++ +   + SVLE HH ++A ++L +
Sbjct: 739 PLGILSSASGNNSVLEVHHCSLAIEILSD 767


>UniRef50_A2F408 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1086

 Score = 65.3 bits (152), Expect = 2e-09
 Identities = 28/87 (32%), Positives = 47/87 (54%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN  HA DVTQ     +       + + +E+ A + AA  HD +H G TN F   + +
Sbjct: 807  PYHNWRHACDVTQFVTYEIILSGAEKILSNMELFALIVAALCHDANHDGFTNVFNEKAET 866

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L +++ ++SV+E HH  VA  ++  +
Sbjct: 867  PLGILFKNQSVMETHHCEVAIGIISKE 893


>UniRef50_A0BZK9 Cluster: Chromosome undetermined scaffold_139, whole
            genome shotgun sequence; n=3; Paramecium tetraurelia|Rep:
            Chromosome undetermined scaffold_139, whole genome
            shotgun sequence - Paramecium tetraurelia
          Length = 987

 Score = 65.3 bits (152), Expect = 2e-09
 Identities = 35/104 (33%), Positives = 58/104 (55%), Gaps = 7/104 (6%)
 Frame = +3

Query: 459  SYLKE----HYIRDNPFHNSLHAADVTQSTNVLLNTPALNA---VFTPLEVCAALFAACV 617
            S++KE    + + +NP+HN  H   V Q+ +   +  A  +   +         + ++  
Sbjct: 720  SFIKEMEYNYNVNNNPYHNYDHGITVMQTAHYFCSELAQTSKSKIIDNFNRFILMISSFG 779

Query: 618  HDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
            HDV H G TN F +NS S+LA+ Y+D+SVLE HH A+  ++L+N
Sbjct: 780  HDVGHTGKTNVFEINSLSDLAIRYHDKSVLEQHHAALTIQVLKN 823


>UniRef50_A5DVX9 Cluster: Putative uncharacterized protein; n=1;
           Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
           uncharacterized protein - Lodderomyces elongisporus
           (Yeast) (Saccharomyces elongisporus)
          Length = 638

 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 29/61 (47%), Positives = 40/61 (65%)
 Frame = +3

Query: 546 LNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLA 725
           LN   L  V  P++  A L +A  HDV HPG TN FL+ + + ++L+YND SVLE++H A
Sbjct: 366 LNQGGLGCVINPVQSLALLMSALGHDVGHPGTTNAFLMQNKAPISLIYNDRSVLESYHAA 425

Query: 726 V 728
           V
Sbjct: 426 V 426


>UniRef50_Q3SBD3 Cluster: Sperm phosphodiesterase 5; n=1;
           Strongylocentrotus purpuratus|Rep: Sperm
           phosphodiesterase 5 - Strongylocentrotus purpuratus
           (Purple sea urchin)
          Length = 949

 Score = 64.5 bits (150), Expect = 3e-09
 Identities = 32/87 (36%), Positives = 49/87 (56%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  HA +V Q+   ++ T  L  + T LE+ A + A   HD+DH G  N F V +SS 
Sbjct: 617 YHNWRHAFNVAQTMFSIVMTGKLRKLLTDLEIFALIVACLCHDLDHRGTNNTFQVKTSSP 676

Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755
           L+L+Y   S +E+HH      +L ++G
Sbjct: 677 LSLLYG-TSTMEHHHFDHCIMILNSEG 702


>UniRef50_A2E0V4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
           family protein; n=1; Trichomonas vaginalis G3|Rep:
           3'5'-cyclic nucleotide phosphodiesterase family protein
           - Trichomonas vaginalis G3
          Length = 438

 Score = 64.5 bits (150), Expect = 3e-09
 Identities = 28/87 (32%), Positives = 48/87 (55%)
 Frame = +3

Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
           P+HN  HA DVTQ     +       VFT  E    + A C  D +H G TN + + + +
Sbjct: 211 PYHNWRHAVDVTQFVTYQIMISGHEKVFTKFEFNLVVAAIC-RDANHDGFTNIYNIKAET 269

Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752
            L ++Y ++SV+E HH ++A +++ ++
Sbjct: 270 PLGILYKNQSVMETHHCSIAIQIMSHE 296


>UniRef50_A0D565 Cluster: Chromosome undetermined scaffold_38, whole
            genome shotgun sequence; n=5; Paramecium tetraurelia|Rep:
            Chromosome undetermined scaffold_38, whole genome shotgun
            sequence - Paramecium tetraurelia
          Length = 964

 Score = 64.5 bits (150), Expect = 3e-09
 Identities = 40/113 (35%), Positives = 54/113 (47%), Gaps = 4/113 (3%)
 Frame = +3

Query: 417  DYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVL----LNTPALNAVFTPL 584
            DY     A    +C+   ++  R N FHN  H   V Q T+ +    + T   + +    
Sbjct: 688  DYRISQDALCSFLCALEYKYNKRGNQFHNYDHGVTVMQCTHAISLEIMKTQYAHLLNQFT 747

Query: 585  EVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
            +    L   C HDV H G TN F +NS S L + Y+D SVLE HH A + KLL
Sbjct: 748  KFVLILSGLC-HDVSHTGRTNIFEINSLSNLTIRYHDRSVLEQHHAATSIKLL 799


>UniRef50_Q4SPD6 Cluster: Chromosome 16 SCAF14537, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 16 SCAF14537, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 560

 Score = 64.1 bits (149), Expect = 4e-09
 Identities = 27/46 (58%), Positives = 35/46 (76%)
 Frame = +3

Query: 606 AACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           AA  HD+DHPG  N + +N+ +ELA+ YND S LENHH AVAF++L
Sbjct: 314 AAVCHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQIL 359


>UniRef50_Q17L35 Cluster: Cgmp-dependent 3,5-cyclic
           phosphodiesterase; n=2; Culicidae|Rep: Cgmp-dependent
           3,5-cyclic phosphodiesterase - Aedes aegypti
           (Yellowfever mosquito)
          Length = 502

 Score = 64.1 bits (149), Expect = 4e-09
 Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 3/92 (3%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQ-STNVLLNTPAL-NAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656
           RD P+HN  HA  V   + ++++N   + N V T ++  + L AA  HD+DH G +N + 
Sbjct: 234 RDTPYHNWWHAFSVAHFAYSLMVNLKLIENGVITKMQGFSFLIAAFCHDLDHRGTSNTYQ 293

Query: 657 VNSSSELALMYNDE-SVLENHHLAVAFKLLQN 749
             SSS LA +Y+ E SV E HHL+ A  +L +
Sbjct: 294 TQSSSPLARLYSSEGSVNERHHLSQAICILND 325


>UniRef50_Q4SVG8 Cluster: Chromosome undetermined SCAF13758, whole
           genome shotgun sequence; n=4; Tetraodontidae|Rep:
           Chromosome undetermined SCAF13758, whole genome shotgun
           sequence - Tetraodon nigroviridis (Green puffer)
          Length = 928

 Score = 63.3 bits (147), Expect = 6e-09
 Identities = 33/97 (34%), Positives = 50/97 (51%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           +K++Y +   +HN  HA +  QS   LL +  L    T LEV A + A   HD+DH G+ 
Sbjct: 662 IKKNYRKSVAYHNWRHAFNTAQSMFALLKSGRLQNELTDLEVLALMIATLSHDLDHRGVN 721

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
           N ++  S   LA +Y   S +E+HH      +L + G
Sbjct: 722 NSYIQRSEHPLAQLY-CHSTMEHHHFDHCLMILNSPG 757


>UniRef50_Q9VFI9 Cluster: CG8279-PA; n=8; Endopterygota|Rep: CG8279-PA
            - Drosophila melanogaster (Fruit fly)
          Length = 1131

 Score = 63.3 bits (147), Expect = 6e-09
 Identities = 32/97 (32%), Positives = 51/97 (52%)
 Frame = +3

Query: 465  LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
            ++++Y R   +HN  HA +V Q+   +L T  +    T LE+   L A   HD+DH G  
Sbjct: 721  VRKNY-RPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTN 779

Query: 645  NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
            N F   + S LA++Y   S +E+HH      +L ++G
Sbjct: 780  NAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEG 815


>UniRef50_UPI0000588CD9 Cluster: PREDICTED: hypothetical protein;
           n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
           hypothetical protein - Strongylocentrotus purpuratus
          Length = 701

 Score = 62.9 bits (146), Expect = 8e-09
 Identities = 35/97 (36%), Positives = 52/97 (53%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           +++HY R  PFHN  HA DV     ++L        FT  E+ A  F +  HD+DH GLT
Sbjct: 432 VRKHY-RLVPFHNFCHAFDVCHCMFMILLHS--EGRFTDEEMYAMFFGSICHDMDHRGLT 488

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
           N F     + L  +Y+  S++E+HH A+   +L  +G
Sbjct: 489 NSFHAKFGTPLGKLYS-SSIMESHHFAMIVSILHREG 524


>UniRef50_Q7Q8G2 Cluster: ENSANGP00000013023; n=2; Diptera|Rep:
           ENSANGP00000013023 - Anopheles gambiae str. PEST
          Length = 747

 Score = 62.9 bits (146), Expect = 8e-09
 Identities = 35/98 (35%), Positives = 56/98 (57%), Gaps = 1/98 (1%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641
           +K++Y R+  +HN  HA +VTQ    +L +     +F  +E C AL  AC+ HD+DH G 
Sbjct: 487 VKKNY-RNVTYHNWRHAFNVTQMMFAILTSTQWWKIFGEIE-CLALIIACLCHDLDHRGT 544

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
            N F + +SS LA +Y+  S +E+HH      ++ + G
Sbjct: 545 NNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMIINSPG 581


>UniRef50_UPI0000F1D4E2 Cluster: PREDICTED: similar to
           Phosphodiesterase 5A; n=4; Danio rerio|Rep: PREDICTED:
           similar to Phosphodiesterase 5A - Danio rerio
          Length = 905

 Score = 62.5 bits (145), Expect = 1e-08
 Identities = 31/87 (35%), Positives = 47/87 (54%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  HA    Q    +L T  L +  + LEV A + A+  HD+DH G+ N ++  S+  
Sbjct: 647 YHNWSHALRTAQCMFAMLQTKELKSNLSSLEVLALMIASLSHDLDHRGVNNSYIQRSNQP 706

Query: 675 LALMYNDESVLENHHLAVAFKLLQNDG 755
           LA +Y  +S LE+HH  +   +L N G
Sbjct: 707 LAQLYG-QSSLEHHHYDMCLLILNNPG 732


>UniRef50_A2EHB3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=2; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1213

 Score = 62.5 bits (145), Expect = 1e-08
 Identities = 28/87 (32%), Positives = 45/87 (51%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            P+HN  HA D  Q    ++    L  V T  E+   L A   HD +H G +N +   + +
Sbjct: 915  PYHNFTHAIDTMQFMAHVIILCGLKDVLTQKEILILLVACICHDANHDGFSNNYNYKAQT 974

Query: 672  ELALMYNDESVLENHHLAVAFKLLQND 752
             L++++  +SVLE HH +V+  +L  D
Sbjct: 975  PLSILFKGQSVLETHHCSVSITILSKD 1001


>UniRef50_O76074 Cluster: cGMP-specific 3',5'-cyclic
           phosphodiesterase; n=47; Euteleostomi|Rep: cGMP-specific
           3',5'-cyclic phosphodiesterase - Homo sapiens (Human)
          Length = 875

 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 31/97 (31%), Positives = 50/97 (51%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           +K++Y ++  +HN  HA +  Q     L    +    T LE+ A L AA  HD+DH G+ 
Sbjct: 602 VKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVN 661

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
           N ++  S   LA +Y   S++E+HH      +L + G
Sbjct: 662 NSYIQRSEHPLAQLY-CHSIMEHHHFDQCLMILNSPG 697


>UniRef50_Q9VJ79 Cluster: Dual 3',5'-cyclic-AMP and -GMP
            phosphodiesterase 11; n=9; Eumetazoa|Rep: Dual
            3',5'-cyclic-AMP and -GMP phosphodiesterase 11 -
            Drosophila melanogaster (Fruit fly)
          Length = 1451

 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
 Frame = +3

Query: 465  LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACV-HDVDHPGL 641
            +K++Y R+  +HN  HA +V Q    +L T     +F  +E C AL   C+ HD+DH G 
Sbjct: 850  VKKNY-RNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIE-CLALIIGCLCHDLDHRGT 907

Query: 642  TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
             N F + +SS LA +Y+  S +E+HH      +L + G
Sbjct: 908  NNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPG 944


>UniRef50_Q4DUD4 Cluster: CAMP-specific phosphodiesterase, putative;
           n=2; Trypanosoma|Rep: CAMP-specific phosphodiesterase,
           putative - Trypanosoma cruzi
          Length = 654

 Score = 61.3 bits (142), Expect = 3e-08
 Identities = 32/96 (33%), Positives = 47/96 (48%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           L E+Y ++N +HN+LHAAD  Q   ++L       +FT  EV  A  A       HPG++
Sbjct: 171 LFENYSKENAYHNALHAADSVQMLFLILREKPATLIFTENEVILAFLATLSLGFVHPGVS 230

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQND 752
           N FL      L L+Y D +  ++  L     LL  +
Sbjct: 231 NAFLARIDHPLVLVYGDMTTQQSAGLTALLYLLNRE 266


>UniRef50_A7TPP3 Cluster: Putative uncharacterized protein; n=1;
           Vanderwaltozyma polyspora DSM 70294|Rep: Putative
           uncharacterized protein - Vanderwaltozyma polyspora DSM
           70294
          Length = 518

 Score = 61.3 bits (142), Expect = 3e-08
 Identities = 37/93 (39%), Positives = 49/93 (52%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           L+  Y + N FHN  HA DV Q+T  L +   L      +       AA  HD+ HPG  
Sbjct: 255 LEASYHQVNKFHNFRHAVDVMQATYQLCDK--LLTKDDHIYKLLLCMAAIGHDIAHPGTN 312

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           N  LVN  S +AL +++ESVLEN H  +  +LL
Sbjct: 313 NNLLVNYKSSVALHFDNESVLENFHQVLFQQLL 345


>UniRef50_P06776 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase
           2; n=2; Saccharomyces cerevisiae|Rep:
           3',5'-cyclic-nucleotide phosphodiesterase 2 -
           Saccharomyces cerevisiae (Baker's yeast)
          Length = 526

 Score = 61.3 bits (142), Expect = 3e-08
 Identities = 38/93 (40%), Positives = 49/93 (52%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           L+  Y + N FHN  HA DV Q+T  L  T  L     P++      AA  HDV HPG  
Sbjct: 254 LESSYHQVNKFHNFRHAIDVMQATWRLC-TYLLKD--NPVQTLLLCMAAIGHDVGHPGTN 310

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
           NQ L N  SE+A  + + S+LEN H  +  +LL
Sbjct: 311 NQLLCNCESEVAQNFKNVSILENFHRELFQQLL 343


>UniRef50_Q95Z92 Cluster: Possible phosphodiesterase; n=2;
           Leishmania|Rep: Possible phosphodiesterase - Leishmania
           major
          Length = 725

 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 30/89 (33%), Positives = 45/89 (50%)
 Frame = +3

Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656
           Y  DN +HN+ HAAD  Q  ++    P +N +F+  E+     A    DV HPG ++  L
Sbjct: 194 YPLDNSYHNATHAADALQMMSLFFREPTVNFLFSDEEIAICFLAVLAVDVAHPGASDTLL 253

Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLL 743
           V     LA ++ D ++ E+  L V   LL
Sbjct: 254 VALDHPLASVFGDVAITEHASLLVLTSLL 282


>UniRef50_Q6FM93 Cluster: Similar to sp|P06776 Saccharomyces
           cerevisiae YOR360c PDE2 high affinity 3; n=1; Candida
           glabrata|Rep: Similar to sp|P06776 Saccharomyces
           cerevisiae YOR360c PDE2 high affinity 3 - Candida
           glabrata (Yeast) (Torulopsis glabrata)
          Length = 575

 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQST-NVLLNTPALNAV-FTPLEVCAALFAACVHDVDHPG 638
           ++  Y + N FHN  HA DV Q+T  +  N     ++  +PL V     +A  HD+ HPG
Sbjct: 243 IEASYHQINKFHNFRHAVDVMQATWQICSNLGGNGSIDLSPLTVLLLSMSAIGHDIGHPG 302

Query: 639 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
             NQ L    S LA  ++++SVLEN H  +   LL
Sbjct: 303 TNNQLLCQHESFLATNFDNKSVLENFHNTLFQNLL 337


>UniRef50_P16499 Cluster: Rod cGMP-specific 3',5'-cyclic
           phosphodiesterase subunit alpha; n=90; Vertebrata|Rep:
           Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit
           alpha - Homo sapiens (Human)
          Length = 860

 Score = 60.5 bits (140), Expect = 4e-08
 Identities = 33/86 (38%), Positives = 47/86 (54%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  H  +V Q+   LL T  L   FT LE  A + AA  HD+DH G  N + + S + 
Sbjct: 558 YHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNP 617

Query: 675 LALMYNDESVLENHHLAVAFKLLQND 752
           LA ++   S+LE HHL     LL+++
Sbjct: 618 LAKLHG-SSILERHHLEFGKTLLRDE 642


>UniRef50_Q7YYN8 Cluster: Phosphdiesterase, possible; n=2;
            Cryptosporidium|Rep: Phosphdiesterase, possible -
            Cryptosporidium parvum
          Length = 1001

 Score = 59.7 bits (138), Expect = 8e-08
 Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 24/122 (19%)
 Frame = +3

Query: 459  SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPG 638
            S L ++Y  +NPFHN  HA  ++ + N  L+ P++      LE    + ++  HD+DHPG
Sbjct: 711  SELIKYYHEENPFHNFHHAVSISITLNNWLDKPSVRHYVNSLEAYCLIISSLSHDLDHPG 770

Query: 639  LTN------------------------QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
            LTN                        + L N++     +YN+ SVLENHH ++ F +L 
Sbjct: 771  LTNDMIKELNILSRKVLQEFTTDEQFFEILQNNTLSTLKIYNNFSVLENHHSSLLFVILN 830

Query: 747  ND 752
            ++
Sbjct: 831  DE 832


>UniRef50_A3FPW6 Cluster: Phosphdiesterase, putative; n=1;
            Cryptosporidium parvum Iowa II|Rep: Phosphdiesterase,
            putative - Cryptosporidium parvum Iowa II
          Length = 1206

 Score = 59.7 bits (138), Expect = 8e-08
 Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 24/122 (19%)
 Frame = +3

Query: 459  SYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPG 638
            S L ++Y  +NPFHN  HA  ++ + N  L+ P++      LE    + ++  HD+DHPG
Sbjct: 916  SELIKYYHEENPFHNFHHAVSISITLNNWLDKPSVRHYVNSLEAYCLIISSLSHDLDHPG 975

Query: 639  LTN------------------------QFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
            LTN                        + L N++     +YN+ SVLENHH ++ F +L 
Sbjct: 976  LTNDMIKELNILSRKVLQEFTTDEQFFEILQNNTLSTLKIYNNFSVLENHHSSLLFVILN 1035

Query: 747  ND 752
            ++
Sbjct: 1036 DE 1037


>UniRef50_A2FQB0 Cluster: GAF domain containing protein; n=1;
            Trichomonas vaginalis G3|Rep: GAF domain containing
            protein - Trichomonas vaginalis G3
          Length = 1042

 Score = 59.7 bits (138), Expect = 8e-08
 Identities = 28/88 (31%), Positives = 48/88 (54%)
 Frame = +3

Query: 486  DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665
            D P+HN  HA DV Q  + +L +     +F P+E+ A   AA  HD  H G +N F   +
Sbjct: 797  DVPYHNWRHACDVVQFVSFVLQSINAKEIFEPIEISAIFIAAICHDAGHDGYSNIFNRQA 856

Query: 666  SSELALMYNDESVLENHHLAVAFKLLQN 749
            S+ L  +Y+ ++  E  HL++  +++ +
Sbjct: 857  STPLGQIYSGKNCEELFHLSLIARVVNS 884


>UniRef50_Q16HU8 Cluster: Camp and camp-inhibited cgmp 3,5-cyclic
           phosphodiesterase; n=5; Eumetazoa|Rep: Camp and
           camp-inhibited cgmp 3,5-cyclic phosphodiesterase - Aedes
           aegypti (Yellowfever mosquito)
          Length = 767

 Score = 59.3 bits (137), Expect = 1e-07
 Identities = 33/98 (33%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQST-NVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641
           +K++Y R  P+HN  H   V  +  +++ N P    VF P E  A    +  HD+DH G 
Sbjct: 505 VKKNY-RRVPYHNWTHGFSVANTMYSIIKNCPH---VFRPNECLALFIGSLCHDLDHRGK 560

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
            N+F++++ S LA +Y+  S +E+HH      +LQ +G
Sbjct: 561 NNKFMLDTESPLAAIYS-TSTMEHHHFNQTVTILQQEG 597


>UniRef50_UPI000023CCA1 Cluster: hypothetical protein FG06914.1;
           n=1; Gibberella zeae PH-1|Rep: hypothetical protein
           FG06914.1 - Gibberella zeae PH-1
          Length = 886

 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 27/60 (45%), Positives = 37/60 (61%)
 Frame = +3

Query: 567 AVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           ++ TP E    L  A  HDV HPG+ N FLV  ++ LA +YND SVLE+ H A   ++L+
Sbjct: 355 SLITPFEALTLLITAIGHDVGHPGVNNGFLVTLNAPLAQLYNDRSVLESFHCAAYSQILR 414


>UniRef50_A2DM77 Cluster: GAF domain containing protein; n=1;
            Trichomonas vaginalis G3|Rep: GAF domain containing
            protein - Trichomonas vaginalis G3
          Length = 1072

 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 28/88 (31%), Positives = 45/88 (51%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            PFHN   A D  Q  N+L+N   L  +  P E  A + A   HD+ H G+ N++L  ++S
Sbjct: 820  PFHNFYLAIDQLQFLNILINEGNLERILQPTEFLALIIATLCHDMGHDGVDNKYLRETNS 879

Query: 672  ELALMYNDESVLENHHLAVAFKLLQNDG 755
             +   +  E   ENHH  +  ++++  G
Sbjct: 880  PIFAAF-PEYPNENHHFVILIEVIKRSG 906


>UniRef50_Q1DXU2 Cluster: Putative uncharacterized protein; n=1;
           Coccidioides immitis|Rep: Putative uncharacterized
           protein - Coccidioides immitis
          Length = 900

 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 26/62 (41%), Positives = 39/62 (62%)
 Frame = +3

Query: 561 LNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL 740
           ++++ TP +    L  A  HDV HPG+ N FLV  ++ LA +YND+SVLE  H A   ++
Sbjct: 403 MSSILTPFDALTLLITAIGHDVGHPGVNNVFLVKLNAPLAQLYNDKSVLEAFHCAAYSQI 462

Query: 741 LQ 746
           L+
Sbjct: 463 LR 464


>UniRef50_Q4DJ46 Cluster: Putative uncharacterized protein; n=2;
           Trypanosoma cruzi|Rep: Putative uncharacterized protein
           - Trypanosoma cruzi
          Length = 754

 Score = 58.4 bits (135), Expect = 2e-07
 Identities = 30/85 (35%), Positives = 47/85 (55%)
 Frame = +3

Query: 489 NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
           NPFHN+ HA+D+  + N  L+ P +   F+  E+ + LFA+ V  + H G+TN FL+   
Sbjct: 370 NPFHNAYHASDIVLAANQFLSEPHVAENFSDEELFSFLFASTVMKLGHVGMTNAFLIKIH 429

Query: 669 SELALMYNDESVLENHHLAVAFKLL 743
              A +Y   S  ++  LA+   LL
Sbjct: 430 HPYAALYGFFSPQQSVSLALGLTLL 454


>UniRef50_Q4SVG0 Cluster: Chromosome 1 SCAF13759, whole genome
           shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 1
           SCAF13759, whole genome shotgun sequence - Tetraodon
           nigroviridis (Green puffer)
          Length = 954

 Score = 58.0 bits (134), Expect = 2e-07
 Identities = 31/86 (36%), Positives = 46/86 (53%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  H  +V Q+   LL T  L   +T LE  A + A   HD+DH G  N + + S + 
Sbjct: 634 YHNWRHGFNVGQTMFTLLMTGDLKRYYTDLECMAMVTAGFCHDIDHRGTNNLYQMKSGNP 693

Query: 675 LALMYNDESVLENHHLAVAFKLLQND 752
           LA ++   S+LE HHL     LL+++
Sbjct: 694 LAKLHG-SSILERHHLEFGKTLLRDE 718


>UniRef50_A4RPY9 Cluster: Putative uncharacterized protein; n=1;
           Magnaporthe grisea|Rep: Putative uncharacterized protein
           - Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 862

 Score = 58.0 bits (134), Expect = 2e-07
 Identities = 42/129 (32%), Positives = 60/129 (46%), Gaps = 21/129 (16%)
 Frame = +3

Query: 423 SSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQST-NVLLN---------------- 551
           S+D  + FL  C     +++   P+HN  H  DV Q+T N L+                 
Sbjct: 343 STDQLSTFLIACRAAYNNFV---PYHNFRHVIDVLQATFNFLVQIGSLPPFPPRSDDYIA 399

Query: 552 ----TPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHH 719
               T  +  +  P E    L  A  HDV HPG+ N FLV  ++ LA +YND SVLE+ H
Sbjct: 400 TPQPTSPIATLMKPFEALTLLVTAVGHDVGHPGVNNGFLVTLNAPLAQLYNDRSVLESFH 459

Query: 720 LAVAFKLLQ 746
            A   ++L+
Sbjct: 460 CAAYSQILR 468


>UniRef50_A2FK96 Cluster: GAF domain containing protein; n=3;
            Trichomonas vaginalis G3|Rep: GAF domain containing
            protein - Trichomonas vaginalis G3
          Length = 1174

 Score = 57.6 bits (133), Expect = 3e-07
 Identities = 30/84 (35%), Positives = 45/84 (53%)
 Frame = +3

Query: 492  PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
            PFHN  HA DVTQ   +++    L + FT LE+ A L +A  HD+ H G          +
Sbjct: 931  PFHNFNHAVDVTQMAYMIVKVGRLFSNFTKLEILALLVSAICHDMGHRGKMGT-SSKVQT 989

Query: 672  ELALMYNDESVLENHHLAVAFKLL 743
             L+L++ D+ V+E  H + A K +
Sbjct: 990  PLSLLFKDQPVMETFHCSSAIKTI 1013


>UniRef50_A2DM90 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
           family protein; n=2; Trichomonas vaginalis G3|Rep:
           3'5'-cyclic nucleotide phosphodiesterase family protein
           - Trichomonas vaginalis G3
          Length = 457

 Score = 57.6 bits (133), Expect = 3e-07
 Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 1/94 (1%)
 Frame = +3

Query: 468 KEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTN 647
           + HY  + P+HN  HA D TQ    L+  P +  +  PL+  A L +   HD++H G TN
Sbjct: 203 QSHY-NNVPYHNWRHATDATQFVFYLITMPHVEEMLPPLDRFALLLSVICHDLEHNGHTN 261

Query: 648 QFLVNSSSELALMYN-DESVLENHHLAVAFKLLQ 746
            +    +SE +     D   LENHH  +A  L+Q
Sbjct: 262 DYHRKVNSEFSQEAGPDLPPLENHHQKLAKVLIQ 295


>UniRef50_Q9Y233 Cluster: cAMP and cAMP-inhibited cGMP 3',5'-cyclic
           phosphodiesterase 10A; n=44; Euteleostomi|Rep: cAMP and
           cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A -
           Homo sapiens (Human)
          Length = 779

 Score = 57.2 bits (132), Expect = 4e-07
 Identities = 33/97 (34%), Positives = 49/97 (50%)
 Frame = +3

Query: 465 LKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLT 644
           +K++Y R  P+HN  HA  V      +L     + +FT LE    L A   HD+DH G +
Sbjct: 505 VKKNY-RRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFS 561

Query: 645 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDG 755
           N +L      LA +Y+  S +E HH +    +LQ +G
Sbjct: 562 NSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEG 597


>UniRef50_Q6BSL2 Cluster: Similar to tr|O94034 Candida albicans
           Nucleotide phosphodiesterase; n=2;
           Saccharomycetaceae|Rep: Similar to tr|O94034 Candida
           albicans Nucleotide phosphodiesterase - Debaryomyces
           hansenii (Yeast) (Torulaspora hansenii)
          Length = 611

 Score = 56.8 bits (131), Expect = 5e-07
 Identities = 25/55 (45%), Positives = 37/55 (67%)
 Frame = +3

Query: 564 NAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728
           +A    ++  A L AA  HDV HPG+TN F++  S+ ++L+YN+ SVLE +H AV
Sbjct: 376 SAHMNSIQTLALLIAALGHDVGHPGVTNAFMIKHSAPMSLIYNERSVLELYHSAV 430


>UniRef50_A1D4A4 Cluster: High affinity cAMP phosphodiesterase,
           putative; n=8; Trichocomaceae|Rep: High affinity cAMP
           phosphodiesterase, putative - Neosartorya fischeri
           (strain ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
           fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
          Length = 1009

 Score = 56.8 bits (131), Expect = 5e-07
 Identities = 26/63 (41%), Positives = 39/63 (61%)
 Frame = +3

Query: 558 ALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK 737
           ++ ++ TP +    L +A  HDV HPG+ N FLV  ++ LA +YND SVLE  H A   +
Sbjct: 401 SIASLLTPFDTLTLLISAIGHDVGHPGVNNFFLVKLNAPLAQLYNDNSVLEAFHCAAFSQ 460

Query: 738 LLQ 746
           +L+
Sbjct: 461 ILR 463


>UniRef50_Q2H9G5 Cluster: Putative uncharacterized protein; n=1;
           Chaetomium globosum|Rep: Putative uncharacterized
           protein - Chaetomium globosum (Soil fungus)
          Length = 894

 Score = 56.0 bits (129), Expect = 9e-07
 Identities = 26/56 (46%), Positives = 34/56 (60%)
 Frame = +3

Query: 579 PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           P E    L  A  HDV HPG+ N FLV  ++ LA +YND SVLE+ H A   ++L+
Sbjct: 389 PFEALTLLITAIGHDVGHPGVNNGFLVTLNAPLAQLYNDRSVLESFHCAAYSQILR 444


>UniRef50_Q0V6F8 Cluster: Putative uncharacterized protein; n=1;
           Phaeosphaeria nodorum|Rep: Putative uncharacterized
           protein - Phaeosphaeria nodorum (Septoria nodorum)
          Length = 953

 Score = 56.0 bits (129), Expect = 9e-07
 Identities = 28/72 (38%), Positives = 43/72 (59%)
 Frame = +3

Query: 531 STNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLE 710
           S+ +L  +P +  +  P +    L +A  HDV HPG+ N FLV  ++ LA +YND SVLE
Sbjct: 379 SSGLLPKSP-IAELLKPFDALTLLISAIGHDVGHPGVNNAFLVALNAPLAQLYNDRSVLE 437

Query: 711 NHHLAVAFKLLQ 746
           + H A   ++L+
Sbjct: 438 SFHCAAYSQILR 449


>UniRef50_UPI0000E46CDB Cluster: PREDICTED: similar to
           phosphodiesterase 9A; n=1; Strongylocentrotus
           purpuratus|Rep: PREDICTED: similar to phosphodiesterase
           9A - Strongylocentrotus purpuratus
          Length = 526

 Score = 55.6 bits (128), Expect = 1e-06
 Identities = 24/41 (58%), Positives = 31/41 (75%)
 Frame = +3

Query: 624 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           +D PG  N + VN+ +ELAL YND S LENHH +VAFK+L+
Sbjct: 238 LDRPGYNNAYHVNAGTELALRYNDISPLENHHCSVAFKILE 278


>UniRef50_A6S8A0 Cluster: Putative uncharacterized protein; n=2;
           Sclerotiniaceae|Rep: Putative uncharacterized protein -
           Botryotinia fuckeliana B05.10
          Length = 945

 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 24/56 (42%), Positives = 35/56 (62%)
 Frame = +3

Query: 579 PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
           P +    +  A  HDV HPG+ N FLV+ ++ LA +YND SVLE+ H A   ++L+
Sbjct: 425 PFDALTLMITAIGHDVGHPGVNNAFLVHLNAPLAQLYNDRSVLESFHCAAYSQILR 480


>UniRef50_A7SW30 Cluster: Predicted protein; n=2; Nematostella
           vectensis|Rep: Predicted protein - Nematostella
           vectensis
          Length = 600

 Score = 54.0 bits (124), Expect = 4e-06
 Identities = 30/91 (32%), Positives = 45/91 (49%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVN 662
           RD P+HN  HA  V  S  +++     N   T  E  +   A   HDVDH G  N F+++
Sbjct: 365 RDIPYHNWCHAFSVAHSLWIVIRD---NKSLTDYEKLSLFIAGICHDVDHRGKNNAFMLH 421

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQNDG 755
             + LA +Y   S +E HH      +L+++G
Sbjct: 422 CKTPLANLYT-TSTMEWHHFKQGVFILESEG 451


>UniRef50_A0BZW8 Cluster: Chromosome undetermined scaffold_14, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_14,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 454

 Score = 54.0 bits (124), Expect = 4e-06
 Identities = 25/85 (29%), Positives = 44/85 (51%)
 Frame = +3

Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
           P+HN  HA  ++Q          L      LE+ +A+ A   HD++H G+ N + +  S 
Sbjct: 179 PYHNFTHAFQLSQLLFSCYMKSDLKKFCNQLEIFSAILAGLGHDLNHKGVNNMYKIKKSK 238

Query: 672 ELALMYNDESVLENHHLAVAFKLLQ 746
           +  ++ ++ +VLEN H A  F ++Q
Sbjct: 239 KFNVLTSEIAVLENMHCATFFNIIQ 263


>UniRef50_Q6CY30 Cluster: Similar to sp|P06776 Saccharomyces
           cerevisiae YOR360c PDE2 high affinity 3; n=1;
           Kluyveromyces lactis|Rep: Similar to sp|P06776
           Saccharomyces cerevisiae YOR360c PDE2 high affinity 3 -
           Kluyveromyces lactis (Yeast) (Candida sphaerica)
          Length = 516

 Score = 54.0 bits (124), Expect = 4e-06
 Identities = 33/91 (36%), Positives = 46/91 (50%)
 Frame = +3

Query: 477 YIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656
           Y + N FHN  HA DV Q+T  L +   L  + + L +C    AA  HDV HPG  N   
Sbjct: 260 YHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFL-LC---IAAIGHDVAHPGTNNMLF 315

Query: 657 VNSSSELALMYNDESVLENHHLAVAFKLLQN 749
               S ++  Y ++SVLEN H  +   +L +
Sbjct: 316 NKYVSPISKYYKEQSVLENFHADIYLDILSH 346


>UniRef50_UPI00006CD10E Cluster: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein; n=1; Tetrahymena
           thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
           phosphodiesterase family protein - Tetrahymena
           thermophila SB210
          Length = 516

 Score = 53.6 bits (123), Expect = 5e-06
 Identities = 24/87 (27%), Positives = 44/87 (50%)
 Frame = +3

Query: 492 PFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
           P+HN  HA  ++Q    +  T     +    E    L +   HD++H G+ N + V   +
Sbjct: 229 PYHNWTHAFQLSQMFFTVYFTSDFKDLIDSFEFFVGLLSGLAHDMNHKGVNNLYKVKRKA 288

Query: 672 ELALMYNDESVLENHHLAVAFKLLQND 752
           E +L Y +++VLEN H++  F ++  +
Sbjct: 289 ENSLRYMEQAVLENMHVSTFFHIISRN 315


>UniRef50_Q7RXW7 Cluster: Putative uncharacterized protein
           NCU00478.1; n=1; Neurospora crassa|Rep: Putative
           uncharacterized protein NCU00478.1 - Neurospora crassa
          Length = 806

 Score = 53.6 bits (123), Expect = 5e-06
 Identities = 40/112 (35%), Positives = 50/112 (44%), Gaps = 20/112 (17%)
 Frame = +3

Query: 444 FLGVCSYLKEHYIRDNPFHNSLHAADVTQST-------NVLLNTPALNAVFT-------- 578
           FL  C   +  Y+   P+HN  H  DV Q+T         L   P +N   T        
Sbjct: 291 FLKAC---RAAYMGFVPYHNFRHVVDVLQATFQQLLRIGALPPYPNVNGTHTSPIAESPG 347

Query: 579 -----PLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHH 719
                P E    L  A  HDV HPG+ N FL+ + + LA +YND SVLEN H
Sbjct: 348 TPSIGPEEAFTLLLTAIGHDVLHPGVNNGFLIEARAPLAELYNDRSVLENFH 399


>UniRef50_P91119 Cluster: Probable 3',5'-cyclic phosphodiesterase
           pde-5; n=3; Caenorhabditis|Rep: Probable 3',5'-cyclic
           phosphodiesterase pde-5 - Caenorhabditis elegans
          Length = 710

 Score = 53.6 bits (123), Expect = 5e-06
 Identities = 31/88 (35%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
 Frame = +3

Query: 495 FHNSLHAADVTQST-NVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSS 671
           +HN  H   V  +    L+N+P     FT LE  A   +   HD+DH G  N ++   S+
Sbjct: 484 YHNWAHGWSVAHAMFATLMNSPD---AFTKLEALALYVSCLCHDLDHRGKNNAYMKTMST 540

Query: 672 ELALMYNDESVLENHHLAVAFKLLQNDG 755
            LA +Y+  SV+E HH      +LQ DG
Sbjct: 541 PLASIYS-TSVMERHHFNQTVTILQQDG 567


>UniRef50_Q758Y3 Cluster: ADR395Cp; n=1; Eremothecium gossypii|Rep:
           ADR395Cp - Ashbya gossypii (Yeast) (Eremothecium
           gossypii)
          Length = 480

 Score = 53.2 bits (122), Expect = 7e-06
 Identities = 35/94 (37%), Positives = 47/94 (50%)
 Frame = +3

Query: 462 YLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGL 641
           +L+  Y + N F N  HA DV Q+T  L +   L+   + L +C    +A  HDV HPG 
Sbjct: 224 HLECSYHQGNKFPNFRHAVDVMQATYQLCDLLKLDPGIS-LTLC---ISAIGHDVAHPGT 279

Query: 642 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLL 743
            N  +    S +A  YN  SVLEN H  V   +L
Sbjct: 280 NNALMCKYGSPVAKHYNGVSVLENFHSDVFISIL 313


>UniRef50_A2FSQ8 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1017

 Score = 52.0 bits (119), Expect = 2e-05
 Identities = 30/106 (28%), Positives = 52/106 (49%)
 Frame = +3

Query: 429  DTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFA 608
            D  +++  + S +K H  ++ P+HN  HA D  Q    L     L   F  L+      +
Sbjct: 778  DDQSFYRFLESCMKSH--KNYPYHNWSHAVDTLQFLYYLYYRANLTKYFDELQKTCLFIS 835

Query: 609  ACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQ 746
            A  HDV H G ++ + V++ S  AL++ +ES +E    +   +LL+
Sbjct: 836  ALCHDVSHNGFSSYYHVSAQSRTALLFGNESPMEILSFSKTAELLE 881


>UniRef50_A6R1R4 Cluster: Predicted protein; n=1; Ajellomyces
           capsulatus NAm1|Rep: Predicted protein - Ajellomyces
           capsulatus NAm1
          Length = 839

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 24/48 (50%), Positives = 33/48 (68%)
 Frame = +3

Query: 606 AACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQN 749
           +A  HDV HPG+ N FLV  ++ LA +YND SVLE+ H A   +LL++
Sbjct: 295 SAIGHDVGHPGVNNVFLVRLNAPLAQLYNDTSVLESFHCAAYSQLLRS 342


>UniRef50_A2FET3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1135

 Score = 51.2 bits (117), Expect = 3e-05
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 1/90 (1%)
 Frame = +3

Query: 483  RDNPFHNSLHAADVTQSTNVLLNTPALNA-VFTPLEVCAALFAACVHDVDHPGLTNQFLV 659
            ++N +HN  HA +  Q    ++    ++     P++  A + A  +HD+ H G +N++ +
Sbjct: 887  KNNKYHNWNHAVETVQLCYSIVKRGKMSPRAINPMQTTALILACLLHDICHDGTSNEYHI 946

Query: 660  NSSSELALMYNDESVLENHHLAVAFKLLQN 749
             + S L  ++ D+  LEN  L  + +LL++
Sbjct: 947  KAKSSLYHVFGDDCPLENSSLTRSVRLLKS 976


>UniRef50_A2EA57 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
            family protein; n=1; Trichomonas vaginalis G3|Rep:
            3'5'-cyclic nucleotide phosphodiesterase family protein -
            Trichomonas vaginalis G3
          Length = 1102

 Score = 50.4 bits (115), Expect = 5e-05
 Identities = 27/88 (30%), Positives = 42/88 (47%)
 Frame = +3

Query: 480  IRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLV 659
            I   PFHN  H+ D  Q     L    L     P ++   LFA  +HDV H G  +++  
Sbjct: 857  INQKPFHNFRHSVDCLQFVYYTLLKSRLCNKLDPHQIVGLLFATLLHDVSHNGYNDEYHK 916

Query: 660  NSSSELALMYNDESVLENHHLAVAFKLL 743
            N+ + L  + N+   +E +H  VA K++
Sbjct: 917  NNKTHLYFVDNNYP-METYHCKVASKII 943


>UniRef50_Q4RG61 Cluster: Chromosome 2 SCAF15106, whole genome
           shotgun sequence; n=3; Tetraodontidae|Rep: Chromosome 2
           SCAF15106, whole genome shotgun sequence - Tetraodon
           nigroviridis (Green puffer)
          Length = 899

 Score = 50.0 bits (114), Expect = 6e-05
 Identities = 25/86 (29%), Positives = 41/86 (47%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  H  +V  +   LL T  L   ++ L+  A + AA  HD+DH G  N +    S+ 
Sbjct: 606 YHNWRHGFNVGHTMFCLLQTGRLRKYYSDLDAFAMVAAAFCHDIDHRGTNNLYQTKRSAH 665

Query: 675 LALMYNDESVLENHHLAVAFKLLQND 752
                +  S++E HHL  +  L+  +
Sbjct: 666 PLAKLHGTSIMERHHLEYSKTLMAEE 691


>UniRef50_UPI000065E700 Cluster: Cone cGMP-specific 3',5'-cyclic
           phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP
           phosphodiesterase 6C).; n=1; Takifugu rubripes|Rep: Cone
           cGMP-specific 3',5'-cyclic phosphodiesterase subunit
           alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C). -
           Takifugu rubripes
          Length = 937

 Score = 49.6 bits (113), Expect = 8e-05
 Identities = 25/83 (30%), Positives = 40/83 (48%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  H  +V  +   LL T  L   ++ L+  A + AA  HD+DH G  N +    S+ 
Sbjct: 640 YHNWRHGFNVGHTMFCLLQTGKLRKYYSDLDAFAMVAAAFCHDIDHRGTNNLYQTKRSAH 699

Query: 675 LALMYNDESVLENHHLAVAFKLL 743
                +  S++E HHL  +  L+
Sbjct: 700 PLAKLHGTSIMERHHLEYSKTLM 722


>UniRef50_Q22VA7 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
           family protein; n=1; Tetrahymena thermophila SB210|Rep:
           3'5'-cyclic nucleotide phosphodiesterase family protein
           - Tetrahymena thermophila SB210
          Length = 624

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 23/68 (33%), Positives = 39/68 (57%)
 Frame = +3

Query: 549 NTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 728
           N+P+      P E   A  AA  HD++H GL N + V  +++ ++ Y +  VLEN H + 
Sbjct: 333 NSPSWRDYILPFEFFCAQIAALGHDLNHKGLGNLYKVKRNAQCSINYCELGVLENMHASK 392

Query: 729 AFKLLQND 752
            F++LQ++
Sbjct: 393 LFQILQSN 400


>UniRef50_A2GFY4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
           family protein; n=1; Trichomonas vaginalis G3|Rep:
           3'5'-cyclic nucleotide phosphodiesterase family protein
           - Trichomonas vaginalis G3
          Length = 457

 Score = 48.0 bits (109), Expect = 3e-04
 Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
 Frame = +3

Query: 486 DNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNS 665
           D P+HN  HA D  Q     L    +     P++  + + AA  HDV H G +N F    
Sbjct: 208 DVPYHNWRHACDACQFVYFALLQKPIEHFIQPIDYFSLMTAAICHDVGHNGRSNDFHRQV 267

Query: 666 SSELAL-MYNDESVLENHHLAVAFKLLQND 752
           +S+ A    +++  LE HH  +  + L N+
Sbjct: 268 NSKYAQESGSNQPPLEYHHQKITIEFLSNE 297


>UniRef50_A0D3N1 Cluster: Chromosome undetermined scaffold_36, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_36,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 429

 Score = 48.0 bits (109), Expect = 3e-04
 Identities = 24/83 (28%), Positives = 43/83 (51%)
 Frame = +3

Query: 495 FHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSE 674
           +HN  HA  + Q    +     L    +  ++ AAL A+  HD++H G+ N + V  S +
Sbjct: 161 YHNFTHAFALFQLLFCVYEKSDLKLFVSKQDIFAALLASLSHDINHKGVNNLYKVKKSKK 220

Query: 675 LALMYNDESVLENHHLAVAFKLL 743
           L     +++VLE+ H++  F +L
Sbjct: 221 LNKNICEQAVLESMHVSTLFNIL 243


>UniRef50_Q4QE95 Cluster: Putative uncharacterized protein; n=3;
            Leishmania|Rep: Putative uncharacterized protein -
            Leishmania major
          Length = 1594

 Score = 46.8 bits (106), Expect = 6e-04
 Identities = 26/85 (30%), Positives = 39/85 (45%)
 Frame = +3

Query: 489  NPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSS 668
            NPFHN +HA DV  + +  LN  +  A  +  E    LF A V  + H G  N+ L    
Sbjct: 1052 NPFHNPVHAVDVVMAAHQWLNEGSTGAALSDDEAMTFLFTAMVQQLAHTGADNRLLGQLK 1111

Query: 669  SELALMYNDESVLENHHLAVAFKLL 743
               A++ +  S  +   +A+   LL
Sbjct: 1112 HPYAMLCSYASPQQGATVALVMALL 1136


>UniRef50_UPI0000D56333 Cluster: PREDICTED: similar to
           cGMP-dependent 3,5-cyclic phosphodiesterase (Cyclic
           GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE);
           n=1; Tribolium castaneum|Rep: PREDICTED: similar to
           cGMP-dependent 3,5-cyclic phosphodiesterase (Cyclic
           GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) -
           Tribolium castaneum
          Length = 666

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 3/94 (3%)
 Frame = +3

Query: 483 RDNPFHNSLHAADVTQSTNVLLNTPAL--NAVFTPLEVCAALFAACVHDVDHPGLTNQFL 656
           R+ PFHN +H         + L    L  +   T LE  A       HDVD+    + F 
Sbjct: 469 REVPFHNWMHLFSTAHFAYLCLTHLQLVEDKYITQLEALAYFVTCLCHDVDYRAANSSFQ 528

Query: 657 VNSSSELALMYNDE-SVLENHHLAVAFKLLQNDG 755
              S  L  +Y+   SV+E H L+   ++L ++G
Sbjct: 529 QTPSDGLCTLYSSPGSVMERHRLSQILRILNSEG 562


>UniRef50_UPI000065DEB3 Cluster: Dual 3',5'-cyclic-AMP and -GMP
           phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP
           and cGMP phosphodiesterase 11A).; n=1; Takifugu
           rubripes|Rep: Dual 3',5'-cyclic-AMP and -GMP
           phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP
           and cGMP phosphodiesterase 11A). - Takifugu rubripes
          Length = 937

 Score = 31.5 bits (68), Expect(2) = 0.20
 Identities = 13/31 (41%), Positives = 20/31 (64%)
 Frame = +3

Query: 663 SSSELALMYNDESVLENHHLAVAFKLLQNDG 755
           + S LAL+Y   + LE+HH   A  +LQ++G
Sbjct: 741 TGSALALLYGTSATLEHHHFNHAVMILQSEG 771



 Score = 25.8 bits (54), Expect(2) = 0.20
 Identities = 12/27 (44%), Positives = 14/27 (51%), Gaps = 1/27 (3%)
 Frame = +3

Query: 597 ALFAACV-HDVDHPGLTNQFLVNSSSE 674
           AL   C+ HD+DH G  N F     SE
Sbjct: 689 ALMVGCLCHDLDHRGTNNAFQAKCVSE 715


>UniRef50_A4RH78 Cluster: Putative uncharacterized protein; n=1;
           Magnaporthe grisea|Rep: Putative uncharacterized protein
           - Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 876

 Score = 37.5 bits (83), Expect = 0.35
 Identities = 21/65 (32%), Positives = 36/65 (55%)
 Frame = +1

Query: 88  DKQQELDLPSLQVEETSERGAKKKEKPRHGGPATTMSQISGVKRTLTHTNSFTGERVPRY 267
           DKQ+  +LP L+VEE++E G ++K   + GG    +S ++ ++     T S +   V  +
Sbjct: 195 DKQRGTELPDLEVEESTEEGQERKPLVKTGGIIREVSAMASIEDV---TGSGSTHHVVLH 251

Query: 268 GVETP 282
           GV  P
Sbjct: 252 GVHWP 256


>UniRef50_A7CYI8 Cluster: Two component transcriptional regulator,
           winged helix family; n=1; Opitutaceae bacterium
           TAV2|Rep: Two component transcriptional regulator,
           winged helix family - Opitutaceae bacterium TAV2
          Length = 338

 Score = 36.7 bits (81), Expect = 0.62
 Identities = 21/50 (42%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
 Frame = +2

Query: 584 RSLRCSFRCLRPRCRSPGPHQSIPRQL-QFRTRTNVQRRVSPREPPPCSR 730
           RSLR SFR    RC S    Q +PR+  Q R      RR     P PC R
Sbjct: 10  RSLRASFRAFPRRCPSAQTQQGVPRRARQRRLCPRESRRACRHAPRPCHR 59


>UniRef50_A4RJX0 Cluster: Putative uncharacterized protein; n=2;
            Sordariomycetes|Rep: Putative uncharacterized protein -
            Magnaporthe grisea (Rice blast fungus) (Pyricularia
            grisea)
          Length = 1497

 Score = 36.7 bits (81), Expect = 0.62
 Identities = 16/59 (27%), Positives = 34/59 (57%)
 Frame = +2

Query: 11   TRS*ATSQIPASPATRSPSISAPHFWTNNRSLTYHPYKSKKLRNAAPRKRKNHVMADQR 187
            ++S +TSQIP    TR+P +  P     +++    P  ++KLR  +P+K +  + ++++
Sbjct: 1278 SKSMSTSQIPTLRITRNPELGRPDLLGRSQTSPTRPTSTQKLRLQSPQKLRERLQSEKK 1336


>UniRef50_A5KSE4 Cluster: Putative uncharacterized protein; n=1;
           candidate division TM7 genomosp. GTL1|Rep: Putative
           uncharacterized protein - candidate division TM7
           genomosp. GTL1
          Length = 353

 Score = 35.5 bits (78), Expect = 1.4
 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 3/97 (3%)
 Frame = +1

Query: 1   GMLNKELSHFSDSSKSGNQISEYICSTF--LDKQQELDL-PSLQVEETSERGAKKKEKPR 171
           G +  EL  FSD+  S  + +E+   T   L++    D+ P L +E TS +GA    + R
Sbjct: 44  GFVTDELMLFSDTPVSTAEATEFATDTAEKLNEFASFDIKPILILEPTSSQGALDLTRYR 103

Query: 172 HGGPATTMSQISGVKRTLTHTNSFTGERVPRYGVETP 282
           +GG  T ++      +  + T+   G  VP     TP
Sbjct: 104 NGGYDTILNVFFATLKRTSITDEKLGTLVPFPEANTP 140


>UniRef50_Q5C091 Cluster: SJCHGC03341 protein; n=1; Schistosoma
           japonicum|Rep: SJCHGC03341 protein - Schistosoma
           japonicum (Blood fluke)
          Length = 177

 Score = 35.5 bits (78), Expect = 1.4
 Identities = 19/51 (37%), Positives = 23/51 (45%), Gaps = 1/51 (1%)
 Frame = +1

Query: 226 THTNSFTGERVPRYGVETPHXXXXXXXXXXX-DRWGVDIFRIGDLSCGRPL 375
           TH        +P +GVETP+            D WG+DIF I  LS G  L
Sbjct: 127 THATDIDEPTLPIHGVETPNDKELEERFCQSLDEWGIDIFEIDRLSNGHAL 177


>UniRef50_Q9TXJ7 Cluster: Sperm specific transcript protein 20; n=2;
           Caenorhabditis|Rep: Sperm specific transcript protein 20
           - Caenorhabditis elegans
          Length = 231

 Score = 34.7 bits (76), Expect = 2.5
 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 1/51 (1%)
 Frame = +1

Query: 91  KQQELDLPSLQVEETSERGAKKKEKPRHGGPATTMSQISGVK-RTLTHTNS 240
           ++  L+LP L  ++T + G  KKEKP+   P+T+MS I   K R  + +NS
Sbjct: 123 RKTALNLPCLD-KKTKKAGDAKKEKPKMKAPSTSMSDIEKSKSRAASKSNS 172


>UniRef50_O27572 Cluster: Probable tRNA pseudouridine synthase D;
           n=3; Methanobacteriaceae|Rep: Probable tRNA
           pseudouridine synthase D - Methanobacterium
           thermoautotrophicum
          Length = 415

 Score = 34.7 bits (76), Expect = 2.5
 Identities = 16/44 (36%), Positives = 25/44 (56%)
 Frame = -2

Query: 563 KRRCIQQYVCRLCDIGSVERVVERIVSNIVLLKVTANAKKVRAG 432
           KR   +Q++C      S  + +E  + N+  L+VTAN KK+R G
Sbjct: 79  KRAVTRQWICVSNTAPSEVKAIEERIRNVKFLRVTANEKKLRMG 122


>UniRef50_UPI00006CB312 Cluster: hypothetical protein
           TTHERM_00456820; n=1; Tetrahymena thermophila SB210|Rep:
           hypothetical protein TTHERM_00456820 - Tetrahymena
           thermophila SB210
          Length = 842

 Score = 34.3 bits (75), Expect = 3.3
 Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
 Frame = +1

Query: 10  NKELSHFSDSSKSGNQISEYICSTFL-DKQQELDLPSLQVEETSERGAKKKEKPRHGGPA 186
           N +LS++     + NQI + I    + + Q +LD+ S +++  S +  K  +K    GP 
Sbjct: 274 NNDLSNYEFDDANMNQIQQNIQKIDISNSQDQLDIGSSRIDNNSPQSEKDVDKQNQNGPL 333

Query: 187 TTMSQ---ISGVKRTLTHTNSFTGE 252
              S     SG    +  +N+F  E
Sbjct: 334 NFKSSNDYKSGSNTAVVSSNNFNNE 358


>UniRef50_A6R697 Cluster: Predicted protein; n=1; Ajellomyces
           capsulatus NAm1|Rep: Predicted protein - Ajellomyces
           capsulatus NAm1
          Length = 281

 Score = 33.9 bits (74), Expect = 4.4
 Identities = 25/73 (34%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
 Frame = +3

Query: 495 FHNSLHAADVTQST--NVLLNTPALNAVFTPLEVCAALFAACVH--DVDHPGLTNQFLVN 662
           +H+S  +A  T++   NVL  +P    +FTPLE    L A+ VH  +   PG       N
Sbjct: 206 YHSSTSSARTTEALLHNVLAISPVTCIIFTPLEGHRYLMASSVHLLEAALPGNYQMGKQN 265

Query: 663 SSSELALMYNDES 701
             SE  + YN  S
Sbjct: 266 FRSESFVAYNKNS 278


>UniRef50_Q5N7R3 Cluster: Putative uncharacterized protein
           P0034C09.31; n=1; Oryza sativa (japonica
           cultivar-group)|Rep: Putative uncharacterized protein
           P0034C09.31 - Oryza sativa subsp. japonica (Rice)
          Length = 204

 Score = 33.5 bits (73), Expect = 5.8
 Identities = 17/47 (36%), Positives = 24/47 (51%)
 Frame = +2

Query: 581 TRSLRCSFRCLRPRCRSPGPHQSIPRQLQFRTRTNVQRRVSPREPPP 721
           T ++     C R  CR P P  S+P Q + R  + ++   SPR PPP
Sbjct: 121 TEAVAARLGCCRVPCRHPHPPPSVPAQ-RGRCSSWLRSSPSPRPPPP 166


>UniRef50_Q94241 Cluster: Putative uncharacterized protein; n=2;
           Caenorhabditis|Rep: Putative uncharacterized protein -
           Caenorhabditis elegans
          Length = 214

 Score = 33.5 bits (73), Expect = 5.8
 Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 5/120 (4%)
 Frame = +3

Query: 411 AVDYSSDTGAYFLGVCSYLKEHYIRDNPFHNSLHAADVTQSTNVL--LNTPALNAVFTPL 584
           A  Y SD G  FL   S   E  +R  P+H       + Q+       N  A+N V   L
Sbjct: 84  AFQYLSDIGQEFLNENSSRIEQVVR--PYHFLEFDKYIQQAKQRYGDTNKHAMNTVSNEL 141

Query: 585 EVCAALFAACVHDVDHPGLTNQFLVNSSSELALM---YNDESVLENHHLAVAFKLLQNDG 755
           +    +    + DV H G     L N +SEL+ M   Y D++   N    + FK+  + G
Sbjct: 142 QDVTRIMVTNIEDVIHRGEALNILENRASELSGMSKKYRDDAKALNRRSTI-FKVAASIG 200


>UniRef50_A2FIR1 Cluster: Putative uncharacterized protein; n=1;
           Trichomonas vaginalis G3|Rep: Putative uncharacterized
           protein - Trichomonas vaginalis G3
          Length = 500

 Score = 33.5 bits (73), Expect = 5.8
 Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 2/74 (2%)
 Frame = +1

Query: 13  KELSHFSDSSKSGNQISEYICSTFLDK--QQELDLPSLQVEETSERGAKKKEKPRHGGPA 186
           K  SH SD        S  I S++ D   + E +    +++E S+ G+K KEK  +   +
Sbjct: 178 KPKSHTSDKKLKPKHHSRQISSSYSDSISEDEYEPSESEIDEISDSGSKPKEKRSNSSKS 237

Query: 187 TTMSQISGVKRTLT 228
              +  SG ++ L+
Sbjct: 238 KEKTSKSGKEKNLS 251


>UniRef50_Q7SDI5 Cluster: Predicted protein; n=2; Sordariales|Rep:
           Predicted protein - Neurospora crassa
          Length = 611

 Score = 33.5 bits (73), Expect = 5.8
 Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 6/70 (8%)
 Frame = +2

Query: 329 EWIYSASVIC----HAVDHSLLSRTQRSHHGSC*LLFRYRRVLSWRLQLP*GALY--SRQ 490
           +W+Y+ S +        DHSL+SR     H +  LL   R  +SW + +P G+ +  + +
Sbjct: 100 KWLYTHSPVLPFLSRPYDHSLVSRADLPDHPAPILLTDSRGRISWTVSIPQGSEFPLTAE 159

Query: 491 SFPQLSPRCR 520
            F  +  +CR
Sbjct: 160 DFTNVCEKCR 169


>UniRef50_Q4WB96 Cluster: Pectin methylesterase, putative; n=1;
            Aspergillus fumigatus|Rep: Pectin methylesterase,
            putative - Aspergillus fumigatus (Sartorya fumigata)
          Length = 1764

 Score = 31.1 bits (67), Expect(2) = 5.9
 Identities = 16/51 (31%), Positives = 27/51 (52%)
 Frame = +1

Query: 364  GRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRSTIFETILSTTLSTL 516
            G  +T   YT  T+    +T+++PA T +   VT ++T   T L  + ST+
Sbjct: 1560 GAAVTITDYTTLTTTAKTSTVKLPASTDIITVVTTKTTGKTTTLPASTSTI 1610



 Score = 21.0 bits (42), Expect(2) = 5.9
 Identities = 9/20 (45%), Positives = 13/20 (65%)
 Frame = +1

Query: 604  SLPASTMSITRASPINSSST 663
            +LPAST +IT  S +   +T
Sbjct: 1602 TLPASTSTITVLSTVTKGTT 1621


>UniRef50_A0VET3 Cluster: Conserved repeat domain precursor; n=1;
            Delftia acidovorans SPH-1|Rep: Conserved repeat domain
            precursor - Delftia acidovorans SPH-1
          Length = 1396

 Score = 33.1 bits (72), Expect = 7.6
 Identities = 21/68 (30%), Positives = 35/68 (51%)
 Frame = +1

Query: 328  GVDIFRIGDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLRSTIFETILSTTL 507
            G  +  IG  S      +V+  + TSR++  T  +PA   +AF  TL  ++  T+ +TT 
Sbjct: 1311 GSGVANIGVFSVTGGTASVSVLSATSRQITLTSALPAGATIAFRTTLSISVAFTLNATT- 1369

Query: 508  STLPMSHS 531
             TLP  ++
Sbjct: 1370 -TLPNGYA 1376


  Database: uniref50
    Posted date:  Oct 5, 2007 11:19 AM
  Number of letters in database: 575,637,011
  Number of sequences in database:  1,657,284
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 777,192,706
Number of Sequences: 1657284
Number of extensions: 16199023
Number of successful extensions: 53081
Number of sequences better than 10.0: 211
Number of HSP's better than 10.0 without gapping: 50290
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 52965
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 62558016040
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)

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