Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-2375
(650 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 130 6e-30
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 130 6e-30
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 130 6e-30
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 130 6e-30
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 130 6e-30
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 130 6e-30
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 130 6e-30
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 118 1e-26
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 118 2e-26
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 118 2e-26
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 118 2e-26
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 107 3e-23
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 107 3e-23
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 96 1e-19
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 96 1e-19
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 96 1e-19
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 96 1e-19
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 96 1e-19
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 96 1e-19
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 96 1e-19
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 96 1e-19
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 96 1e-19
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 93 1e-18
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 93 1e-18
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 92 1e-18
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 92 1e-18
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 92 1e-18
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 92 1e-18
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 92 1e-18
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 92 1e-18
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 92 1e-18
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 91 2e-18
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 91 2e-18
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 91 2e-18
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 91 2e-18
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 91 2e-18
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 91 2e-18
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 91 3e-18
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 57 5e-08
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 44 4e-04
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 42 0.003
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 42 0.003
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 42 0.003
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 42 0.003
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 42 0.003
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 42 0.003
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 42 0.003
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 42 0.003
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 42 0.003
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 42 0.003
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 42 0.003
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 39 0.018
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 36 0.095
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 36 0.095
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 36 0.095
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 36 0.095
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 36 0.095
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 36 0.095
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 36 0.095
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 36 0.095
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 36 0.095
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 36 0.095
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 36 0.095
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 36 0.095
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 36 0.095
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 36 0.095
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 36 0.095
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 34 0.38
AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protei... 32 1.5
BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated prot... 30 6.2
BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated prot... 30 6.2
AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated prot... 30 6.2
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 130 bits (313), Expect = 6e-30
Identities = 68/132 (51%), Positives = 80/132 (60%), Gaps = 11/132 (8%)
Frame = +3
Query: 195 LALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRLKYDVT-----------GPSPEP 341
L L+A+ AL R+PLH+ + R VG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L NY+DAQYYG I IGTPPQ F VVFDTGSS WVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 522 YVANGTQFAIQY 557
YV NGT F I Y
Sbjct: 131 YVKNGTSFDIHY 142
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 130 bits (313), Expect = 6e-30
Identities = 68/132 (51%), Positives = 80/132 (60%), Gaps = 11/132 (8%)
Frame = +3
Query: 195 LALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRLKYDVT-----------GPSPEP 341
L L+A+ AL R+PLH+ + R VG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L NY+DAQYYG I IGTPPQ F VVFDTGSS WVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 522 YVANGTQFAIQY 557
YV NGT F I Y
Sbjct: 131 YVKNGTSFDIHY 142
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 130 bits (313), Expect = 6e-30
Identities = 68/132 (51%), Positives = 80/132 (60%), Gaps = 11/132 (8%)
Frame = +3
Query: 195 LALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRLKYDVT-----------GPSPEP 341
L L+A+ AL R+PLH+ + R VG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L NY+DAQYYG I IGTPPQ F VVFDTGSS WVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 522 YVANGTQFAIQY 557
YV NGT F I Y
Sbjct: 131 YVKNGTSFDIHY 142
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 130 bits (313), Expect = 6e-30
Identities = 68/132 (51%), Positives = 80/132 (60%), Gaps = 11/132 (8%)
Frame = +3
Query: 195 LALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRLKYDVT-----------GPSPEP 341
L L+A+ AL R+PLH+ + R VG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L NY+DAQYYG I IGTPPQ F VVFDTGSS WVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 522 YVANGTQFAIQY 557
YV NGT F I Y
Sbjct: 131 YVKNGTSFDIHY 142
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 130 bits (313), Expect = 6e-30
Identities = 68/132 (51%), Positives = 80/132 (60%), Gaps = 11/132 (8%)
Frame = +3
Query: 195 LALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRLKYDVT-----------GPSPEP 341
L L+A+ AL R+PLH+ + R VG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L NY+DAQYYG I IGTPPQ F VVFDTGSS WVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 522 YVANGTQFAIQY 557
YV NGT F I Y
Sbjct: 131 YVKNGTSFDIHY 142
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 130 bits (313), Expect = 6e-30
Identities = 68/132 (51%), Positives = 80/132 (60%), Gaps = 11/132 (8%)
Frame = +3
Query: 195 LALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRLKYDVT-----------GPSPEP 341
L L+A+ AL R+PLH+ + R VG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L NY+DAQYYG I IGTPPQ F VVFDTGSS WVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 522 YVANGTQFAIQY 557
YV NGT F I Y
Sbjct: 131 YVKNGTSFDIHY 142
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 130 bits (313), Expect = 6e-30
Identities = 68/132 (51%), Positives = 80/132 (60%), Gaps = 11/132 (8%)
Frame = +3
Query: 195 LALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRLKYDVT-----------GPSPEP 341
L L+A+ AL R+PLH+ + R VG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L NY+DAQYYG I IGTPPQ F VVFDTGSS WVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 522 YVANGTQFAIQY 557
YV NGT F I Y
Sbjct: 131 YVKNGTSFDIHY 142
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 118 bits (285), Expect = 1e-26
Identities = 56/123 (45%), Positives = 78/123 (63%), Gaps = 5/123 (4%)
Frame = +3
Query: 204 IASSVMALYRVPLHRMKTARTHFHXVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 368
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 369 YGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 548
+G I +GTPPQ+F V FDTGSS WVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 549 IQY 557
IQY
Sbjct: 139 IQY 141
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 118 bits (284), Expect = 2e-26
Identities = 56/123 (45%), Positives = 78/123 (63%), Gaps = 5/123 (4%)
Frame = +3
Query: 204 IASSVMALYRVPLHRMKTARTHFHXVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 368
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 369 YGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 548
+G I +GTPPQ+F V FDTGSS WVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 549 IQY 557
IQY
Sbjct: 139 IQY 141
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 118 bits (284), Expect = 2e-26
Identities = 56/123 (45%), Positives = 78/123 (63%), Gaps = 5/123 (4%)
Frame = +3
Query: 204 IASSVMALYRVPLHRMKTARTHFHXVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 368
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 369 YGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 548
+G I +GTPPQ+F V FDTGSS WVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 549 IQY 557
IQY
Sbjct: 139 IQY 141
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 118 bits (284), Expect = 2e-26
Identities = 56/123 (45%), Positives = 78/123 (63%), Gaps = 5/123 (4%)
Frame = +3
Query: 204 IASSVMALYRVPLHRMKTARTHFHXVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 368
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 369 YGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 548
+G I +GTPPQ+F V FDTGSS WVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 549 IQY 557
IQY
Sbjct: 139 IQY 141
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 107 bits (258), Expect = 3e-23
Identities = 50/116 (43%), Positives = 73/116 (62%), Gaps = 5/116 (4%)
Frame = +3
Query: 225 LYRVPLHRMKTARTHFHXV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 389
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 390 TPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQY 557
TPPQ+F V FDTGSS WVPS++CH+ ++ C H++++ S ++ +GT+FAIQY
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQY 137
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 107 bits (258), Expect = 3e-23
Identities = 50/116 (43%), Positives = 73/116 (62%), Gaps = 5/116 (4%)
Frame = +3
Query: 225 LYRVPLHRMKTARTHFHXV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 389
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 390 TPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQY 557
TPPQ+F V FDTGSS WVPS++CH+ ++ C H++++ S ++ +GT+FAIQY
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQY 141
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 95.9 bits (228), Expect = 1e-19
Identities = 40/72 (55%), Positives = 50/72 (69%)
Frame = +3
Query: 342 LSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKT 521
L+NY+D QYYG I IGTPPQ+F VVFDTGSS WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 522 YVANGTQFAIQY 557
Y NGT+ ++Y
Sbjct: 138 YKHNGTELTLRY 149
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 92.7 bits (220), Expect = 1e-18
Identities = 54/136 (39%), Positives = 72/136 (52%), Gaps = 12/136 (8%)
Frame = +3
Query: 186 LFFLALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRL-------KYDVTGPSP--- 335
L L L+A S +Y+VPL R K+ R G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 336 --EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSR 509
+PL NYLD +Y+G I IGTP Q F VVFDTGSS WVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 510 KSKTYVANGTQFAIQY 557
S TY + +I Y
Sbjct: 122 DSSTYQSTSETVSITY 137
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 92.7 bits (220), Expect = 1e-18
Identities = 54/136 (39%), Positives = 72/136 (52%), Gaps = 12/136 (8%)
Frame = +3
Query: 186 LFFLALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRL-------KYDVTGPSP--- 335
L L L+A S +Y+VPL R K+ R G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 336 --EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSR 509
+PL NYLD +Y+G I IGTP Q F VVFDTGSS WVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 510 KSKTYVANGTQFAIQY 557
S TY + +I Y
Sbjct: 122 DSSTYQSTSETVSITY 137
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 92.3 bits (219), Expect = 1e-18
Identities = 41/74 (55%), Positives = 52/74 (70%)
Frame = +3
Query: 336 EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKS 515
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSS WVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 516 KTYVANGTQFAIQY 557
TY G F+IQY
Sbjct: 126 STYSQPGQSFSIQY 139
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 92.3 bits (219), Expect = 1e-18
Identities = 41/74 (55%), Positives = 52/74 (70%)
Frame = +3
Query: 336 EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKS 515
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSS WVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 516 KTYVANGTQFAIQY 557
TY G F+IQY
Sbjct: 126 STYSQPGQSFSIQY 139
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 92.3 bits (219), Expect = 1e-18
Identities = 41/74 (55%), Positives = 52/74 (70%)
Frame = +3
Query: 336 EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKS 515
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSS WVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 516 KTYVANGTQFAIQY 557
TY G F+IQY
Sbjct: 126 STYSQPGQSFSIQY 139
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 92.3 bits (219), Expect = 1e-18
Identities = 41/74 (55%), Positives = 52/74 (70%)
Frame = +3
Query: 336 EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKS 515
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSS WVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 516 KTYVANGTQFAIQY 557
TY G F+IQY
Sbjct: 126 STYSQPGQSFSIQY 139
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 92.3 bits (219), Expect = 1e-18
Identities = 41/74 (55%), Positives = 52/74 (70%)
Frame = +3
Query: 336 EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKS 515
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSS WVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 516 KTYVANGTQFAIQY 557
TY G F+IQY
Sbjct: 126 STYSQPGQSFSIQY 139
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 92.3 bits (219), Expect = 1e-18
Identities = 41/74 (55%), Positives = 52/74 (70%)
Frame = +3
Query: 336 EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKS 515
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSS WVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 516 KTYVANGTQFAIQY 557
TY G F+IQY
Sbjct: 126 STYSQPGQSFSIQY 139
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 92.3 bits (219), Expect = 1e-18
Identities = 41/74 (55%), Positives = 52/74 (70%)
Frame = +3
Query: 336 EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKS 515
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSS WVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 516 KTYVANGTQFAIQY 557
TY G F+IQY
Sbjct: 126 STYSQPGQSFSIQY 139
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/121 (42%), Positives = 71/121 (58%), Gaps = 9/121 (7%)
Frame = +3
Query: 222 ALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 374
A+ +VPL + K+ R G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 375 VISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 554
ISIGTPPQ+F V+FDTGSS WVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 555 Y 557
Y
Sbjct: 134 Y 134
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/121 (42%), Positives = 71/121 (58%), Gaps = 9/121 (7%)
Frame = +3
Query: 222 ALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 374
A+ +VPL + K+ R G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 375 VISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 554
ISIGTPPQ+F V+FDTGSS WVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 555 Y 557
Y
Sbjct: 134 Y 134
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/121 (42%), Positives = 71/121 (58%), Gaps = 9/121 (7%)
Frame = +3
Query: 222 ALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 374
A+ +VPL + K+ R G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 375 VISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 554
ISIGTPPQ+F V+FDTGSS WVPS C + AC H++++ +S TY NG F++Q
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 130
Query: 555 Y 557
Y
Sbjct: 131 Y 131
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/121 (42%), Positives = 71/121 (58%), Gaps = 9/121 (7%)
Frame = +3
Query: 222 ALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 374
A+ +VPL + K+ R G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 375 VISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 554
ISIGTPPQ+F V+FDTGSS WVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 555 Y 557
Y
Sbjct: 134 Y 134
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/121 (42%), Positives = 71/121 (58%), Gaps = 9/121 (7%)
Frame = +3
Query: 222 ALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 374
A+ +VPL + K+ R G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 375 VISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 554
ISIGTPPQ+F V+FDTGSS WVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 555 Y 557
Y
Sbjct: 134 Y 134
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/121 (42%), Positives = 71/121 (58%), Gaps = 9/121 (7%)
Frame = +3
Query: 222 ALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 374
A+ +VPL + K+ R G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 375 VISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 554
ISIGTPPQ+F V+FDTGSS WVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 555 Y 557
Y
Sbjct: 134 Y 134
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 91.1 bits (216), Expect = 3e-18
Identities = 53/136 (38%), Positives = 72/136 (52%), Gaps = 12/136 (8%)
Frame = +3
Query: 186 LFFLALIASSVMALYRVPLHRMKTARTHFHXVGTELELLRL-------KYDVTGPSP--- 335
L L L+A S +Y+VPL R K+ R G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
Query: 336 --EPLSNYLDAQYYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSR 509
+PL NYLD +Y+G I IGTP Q F V+FDTGSS WVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 510 KSKTYVANGTQFAIQY 557
S TY + +I Y
Sbjct: 122 DSSTYQSTSETVSITY 137
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 57.2 bits (132), Expect = 5e-08
Identities = 36/80 (45%), Positives = 47/80 (58%), Gaps = 9/80 (11%)
Frame = +3
Query: 222 ALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 374
A+ +VPL + K+ R G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 375 VISIGTPPQSFXVVFDTGSS 434
ISIGTPPQ+F V+FDTGSS
Sbjct: 76 EISIGTPPQNFLVLFDTGSS 95
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 44.4 bits (100), Expect = 4e-04
Identities = 17/42 (40%), Positives = 24/42 (57%)
Frame = +3
Query: 432 STFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQY 557
S WVPS KC AC+ H +D+ S +Y NGT+ ++Y
Sbjct: 1 SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY 42
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 66
Query: 546 AIQY 557
++Y
Sbjct: 67 TVKY 70
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 41.5 bits (93), Expect = 0.003
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 545
YY + IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 546 AIQY 557
++Y
Sbjct: 146 TVKY 149
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 38.7 bits (86), Expect = 0.018
Identities = 20/58 (34%), Positives = 29/58 (50%)
Frame = +3
Query: 384 IGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQY 557
IGTPPQ ++ DTGSS F V Y + +D+ +S TY + G ++Y
Sbjct: 3 IGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKY 54
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 36.3 bits (80), Expect = 0.095
Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 9/70 (12%)
Frame = +3
Query: 213 SVMALYRVPLHRMKTARTHFHXVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 365
+V+ RVPL + K+ R G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 366 YYGVISIGTP 395
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 108
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 36.3 bits (80), Expect = 0.095
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWVPSKKCHYTNIACLLHNKYDSRKSKTY 524
YY +++G+PPQ+ ++ DTGSS F V + + LH Y + S TY
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 152
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 34.3 bits (75), Expect = 0.38
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +3
Query: 366 YYGVISIGTPPQSFXVVFDTGSSTFWV 446
YY +++G+PPQ+ ++ DTGSS F V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protein
LIP8 protein.
Length = 119
Score = 32.3 bits (70), Expect = 1.5
Identities = 13/33 (39%), Positives = 16/33 (48%)
Frame = -3
Query: 588 WRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCC 490
W GS+R C + V + S SW CR CC
Sbjct: 8 WPGSKRECANCRVGTSSWRSSGWSWWKDCRPCC 40
>BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 6.2
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -3
Query: 582 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 463
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 6.2
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -3
Query: 582 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 463
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated protein
protein.
Length = 129
Score = 30.3 bits (65), Expect = 6.2
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -3
Query: 582 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 463
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 92,056,302
Number of Sequences: 237096
Number of extensions: 1985345
Number of successful extensions: 4253
Number of sequences better than 10.0: 72
Number of HSP's better than 10.0 without gapping: 4046
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4222
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 7253890590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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