Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-2100
(700 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
J04088-1|AAA61209.1| 1531|Homo sapiens TOP2A protein. 144 3e-34
AF071747-1|AAC77388.1| 1531|Homo sapiens topoisomerase II alpha ... 144 3e-34
Z15115-1|CAA78821.1| 1031|Homo sapiens DNA topoisomerase II pro... 142 8e-34
X68060-1|CAA48197.1| 1621|Homo sapiens DNA topoisomerase II prot... 142 8e-34
AY309240-1|AAR16193.1| 373|Homo sapiens antigen MLAA-44 protein. 142 8e-34
AJ011721-1|CAA09753.1| 717|Homo sapiens topoisomerase II beta p... 142 8e-34
AB208879-1|BAD92116.1| 1009|Homo sapiens DNA topoisomerase II, b... 142 8e-34
AJ011741-1|CAA09762.1| 1531|Homo sapiens topoisomerase II alpha ... 142 1e-33
AF087160-1|AAC77432.1| 1598|Homo sapiens DNA topoisomerase II be... 139 8e-33
X53662-1|CAA37706.1| 234|Homo sapiens DNA topoisomerase II prot... 81 3e-15
M27504-1|AAA61210.1| 886|Homo sapiens TOP2A protein. 57 7e-08
BC021863-1|AAH21863.1| 485|Homo sapiens Unknown (protein for IM... 36 0.14
BC068448-1|AAH68448.1| 351|Homo sapiens EF-hand calcium binding... 32 2.3
AY224210-1|AAO34126.1| 351|Homo sapiens neuronal calcium bindin... 32 2.3
AK095533-1|BAC04568.1| 351|Homo sapiens protein ( Homo sapiens ... 32 2.3
AF414126-1|AAP33146.1| 351|Homo sapiens EF-hand calcium binding... 32 2.3
AF193756-1|AAG28412.1| 255|Homo sapiens neuronal calcium bindin... 32 2.3
BC016340-1|AAH16340.1| 100|Homo sapiens EFCBP1 protein protein. 31 4.0
>J04088-1|AAA61209.1| 1531|Homo sapiens TOP2A protein.
Length = 1531
Score = 144 bits (349), Expect = 3e-34
Identities = 67/131 (51%), Positives = 95/131 (72%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL+E E G+HKVFKLQT+++ M FD+ CLKKYD V +ILR+F++LR
Sbjct: 967 KFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELR 1026
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+KYY RK++L G L AE+ KL+NQARFIL K D +++ENK +K +++ LI+RGY DP
Sbjct: 1027 LKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDP 1086
Query: 363 IADWKKRASKI 395
+ WK+ K+
Sbjct: 1087 VKAWKEAQQKV 1097
Score = 32.7 bits (71), Expect = 1.3
Identities = 15/35 (42%), Positives = 20/35 (57%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
LL M +W LTK KKDEL + R++ K K+
Sbjct: 1128 LLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKS 1162
>AF071747-1|AAC77388.1| 1531|Homo sapiens topoisomerase II alpha
protein.
Length = 1531
Score = 144 bits (349), Expect = 3e-34
Identities = 67/131 (51%), Positives = 95/131 (72%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL+E E G+HKVFKLQT+++ M FD+ CLKKYD V +ILR+F++LR
Sbjct: 967 KFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELR 1026
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+KYY RK++L G L AE+ KL+NQARFIL K D +++ENK +K +++ LI+RGY DP
Sbjct: 1027 LKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDP 1086
Query: 363 IADWKKRASKI 395
+ WK+ K+
Sbjct: 1087 VKAWKEAQQKV 1097
Score = 32.7 bits (71), Expect = 1.3
Identities = 15/35 (42%), Positives = 20/35 (57%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
LL M +W LTK KKDEL + R++ K K+
Sbjct: 1128 LLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKS 1162
>Z15115-1|CAA78821.1| 1031|Homo sapiens DNA topoisomerase II
protein.
Length = 1031
Score = 142 bits (345), Expect = 8e-34
Identities = 64/130 (49%), Positives = 93/130 (71%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL++ EA G+HKVFKLQTT++ M FD+ CLKKY+ V++IL+EF+DLR
Sbjct: 393 KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLR 452
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+ YY RK++L G L AE+ KL+NQARFIL K + +EN+ +K +++ L++RGY DP
Sbjct: 453 LSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDP 512
Query: 363 IADWKKRASK 392
+ WK+ K
Sbjct: 513 VKAWKEAQEK 522
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 551 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS 585
>X68060-1|CAA48197.1| 1621|Homo sapiens DNA topoisomerase II protein.
Length = 1621
Score = 142 bits (345), Expect = 8e-34
Identities = 64/130 (49%), Positives = 93/130 (71%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL++ EA G+HKVFKLQTT++ M FD+ CLKKY+ V++IL+EF+DLR
Sbjct: 983 KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLR 1042
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+ YY RK++L G L AE+ KL+NQARFIL K + +EN+ +K +++ L++RGY DP
Sbjct: 1043 LSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDP 1102
Query: 363 IADWKKRASK 392
+ WK+ K
Sbjct: 1103 VKAWKEAQEK 1112
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 1141 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS 1175
>AY309240-1|AAR16193.1| 373|Homo sapiens antigen MLAA-44 protein.
Length = 373
Score = 142 bits (345), Expect = 8e-34
Identities = 64/130 (49%), Positives = 93/130 (71%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL++ EA G+HKVFKLQTT++ M FD+ CLKKY+ V++IL+EF+DLR
Sbjct: 146 KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLR 205
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+ YY RK++L G L AE+ KL+NQARFIL K + +EN+ +K +++ L++RGY DP
Sbjct: 206 LSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDP 265
Query: 363 IADWKKRASK 392
+ WK+ K
Sbjct: 266 VKAWKEAQEK 275
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 304 ILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKS 338
>AJ011721-1|CAA09753.1| 717|Homo sapiens topoisomerase II beta
protein.
Length = 717
Score = 142 bits (345), Expect = 8e-34
Identities = 64/130 (49%), Positives = 93/130 (71%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL++ EA G+HKVFKLQTT++ M FD+ CLKKY+ V++IL+EF+DLR
Sbjct: 79 KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLR 138
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+ YY RK++L G L AE+ KL+NQARFIL K + +EN+ +K +++ L++RGY DP
Sbjct: 139 LSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDP 198
Query: 363 IADWKKRASK 392
+ WK+ K
Sbjct: 199 VKAWKEAQEK 208
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 237 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS 271
>AB208879-1|BAD92116.1| 1009|Homo sapiens DNA topoisomerase II, beta
isozyme variant protein.
Length = 1009
Score = 142 bits (345), Expect = 8e-34
Identities = 64/130 (49%), Positives = 93/130 (71%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL++ EA G+HKVFKLQTT++ M FD+ CLKKY+ V++IL+EF+DLR
Sbjct: 371 KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLR 430
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+ YY RK++L G L AE+ KL+NQARFIL K + +EN+ +K +++ L++RGY DP
Sbjct: 431 LSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDP 490
Query: 363 IADWKKRASK 392
+ WK+ K
Sbjct: 491 VKAWKEAQEK 500
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 529 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS 563
>AJ011741-1|CAA09762.1| 1531|Homo sapiens topoisomerase II alpha
protein.
Length = 1531
Score = 142 bits (343), Expect = 1e-33
Identities = 66/131 (50%), Positives = 94/131 (71%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLR 182
+FVV + KL+E E G+HKVFKLQT+++ M FD+ CLKKYD V +ILR+ ++LR
Sbjct: 967 KFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDLFELR 1026
Query: 183 VKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDP 362
+KYY RK++L G L AE+ KL+NQARFIL K D +++ENK +K +++ LI+RGY DP
Sbjct: 1027 LKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDP 1086
Query: 363 IADWKKRASKI 395
+ WK+ K+
Sbjct: 1087 VKAWKEAQQKV 1097
Score = 32.7 bits (71), Expect = 1.3
Identities = 15/35 (42%), Positives = 20/35 (57%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
LL M +W LTK KKDEL + R++ K K+
Sbjct: 1128 LLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKS 1162
>AF087160-1|AAC77432.1| 1598|Homo sapiens DNA topoisomerase II beta
protein.
Length = 1598
Score = 139 bits (337), Expect = 8e-33
Identities = 63/128 (49%), Positives = 91/128 (71%)
Frame = +3
Query: 9 VVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYDKVEEILREFYDLRVK 188
VV + KL++ EA G+HKVFKLQTT++ M FD+ CLKKY+ V++IL+EF+DLR+
Sbjct: 962 VVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLS 1021
Query: 189 YYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRGYAPDPIA 368
YY RK++L G L AE+ KL+NQARFIL K + +EN+ +K +++ L++RGY DP+
Sbjct: 1022 YYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVK 1081
Query: 369 DWKKRASK 392
WK+ K
Sbjct: 1082 AWKEAQEK 1089
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 1118 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS 1152
>X53662-1|CAA37706.1| 234|Homo sapiens DNA topoisomerase II
protein.
Length = 234
Score = 81.4 bits (192), Expect = 3e-15
Identities = 35/75 (46%), Positives = 52/75 (69%)
Frame = +3
Query: 168 FYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFIL*KCDKGLVVENKKRKAMVEELIKRG 347
F+DLR+ YY RK++L G L AE+ KL+NQARFIL K + +EN+ +K +++ L++RG
Sbjct: 1 FFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRG 60
Query: 348 YAPDPIADWKKRASK 392
Y DP+ WK+ K
Sbjct: 61 YESDPVKAWKEAQEK 75
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 104 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS 138
>M27504-1|AAA61210.1| 886|Homo sapiens TOP2A protein.
Length = 886
Score = 56.8 bits (131), Expect = 7e-08
Identities = 25/47 (53%), Positives = 34/47 (72%)
Frame = +3
Query: 3 RFVVSLLPGKLSEIEAEGIHKVFKLQTTISMTCMNAFDYNCCLKKYD 143
+FVV + KL++ EA G+HKVFKLQTT++ M FD+ CLKKY+
Sbjct: 840 KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYE 886
>BC021863-1|AAH21863.1| 485|Homo sapiens Unknown (protein for
IMAGE:4999541) protein.
Length = 485
Score = 35.9 bits (79), Expect = 0.14
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 532 LLGMSMWMLTKXKKDELLKQRDQXXXXXXXXKNKT 636
+L MS+W LTK K +EL+KQRD K K+
Sbjct: 5 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS 39
>BC068448-1|AAH68448.1| 351|Homo sapiens EF-hand calcium binding
protein 1 protein.
Length = 351
Score = 31.9 bits (69), Expect = 2.3
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 147 VEEILREFYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFIL 272
+EE L EF L +K+YV G L+ KLSN++R+++
Sbjct: 261 IEEDLEEF-QLALKHYVESASSQSGCLRISIQKLSNESRYMI 301
>AY224210-1|AAO34126.1| 351|Homo sapiens neuronal calcium binding
protein 1 protein.
Length = 351
Score = 31.9 bits (69), Expect = 2.3
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 147 VEEILREFYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFIL 272
+EE L EF L +K+YV G L+ KLSN++R+++
Sbjct: 261 IEEDLEEF-QLALKHYVESASSQSGCLRISIQKLSNESRYMI 301
>AK095533-1|BAC04568.1| 351|Homo sapiens protein ( Homo sapiens
cDNA FLJ38214 fis, clone FCBBF1000582, highly similar to
Rattus norvegicus synaptotagmin interacting protein
STIP1 mRNA. ).
Length = 351
Score = 31.9 bits (69), Expect = 2.3
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 147 VEEILREFYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFIL 272
+EE L EF L +K+YV G L+ KLSN++R+++
Sbjct: 261 IEEDLEEF-QLALKHYVESASSQSGCLRISIQKLSNESRYMI 301
>AF414126-1|AAP33146.1| 351|Homo sapiens EF-hand calcium binding
protein 1 protein.
Length = 351
Score = 31.9 bits (69), Expect = 2.3
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 147 VEEILREFYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFIL 272
+EE L EF L +K+YV G L+ KLSN++R+++
Sbjct: 261 IEEDLEEF-QLALKHYVESASSQSGCLRISIQKLSNESRYMI 301
>AF193756-1|AAG28412.1| 255|Homo sapiens neuronal calcium binding
protein NECAB1 protein.
Length = 255
Score = 31.9 bits (69), Expect = 2.3
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 147 VEEILREFYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFIL 272
+EE L EF L +K+YV G L+ KLSN++R+++
Sbjct: 165 IEEDLEEF-QLALKHYVESASSQSGCLRISIQKLSNESRYMI 205
>BC016340-1|AAH16340.1| 100|Homo sapiens EFCBP1 protein protein.
Length = 100
Score = 31.1 bits (67), Expect = 4.0
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 147 VEEILREFYDLRVKYYVRRKDYLEGQLQAEADKLSNQARFIL 272
+EE L EF L +K+YV G L+ KLSN++R+++
Sbjct: 10 MEEDLEEF-QLALKHYVESASSQSGCLRISIQKLSNESRYMI 50
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 77,023,687
Number of Sequences: 237096
Number of extensions: 1276143
Number of successful extensions: 2454
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 2403
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2454
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8063224416
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -