Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-2037
(750 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 262 7e-70
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 262 7e-70
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 262 7e-70
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 262 7e-70
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 262 7e-70
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 262 7e-70
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 262 7e-70
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 262 1e-69
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 262 1e-69
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 250 3e-66
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 250 4e-66
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 250 4e-66
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 250 4e-66
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 223 7e-58
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 203 5e-52
U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic NADP-d... 98 3e-20
BC026231-1|AAH26231.1| 322|Homo sapiens lymphatic vessel endoth... 30 7.7
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 262 bits (643), Expect = 7e-70
Identities = 133/210 (63%), Positives = 158/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W KPIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 262 bits (643), Expect = 7e-70
Identities = 133/210 (63%), Positives = 158/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W KPIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 53.6 bits (123), Expect = 7e-07
Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +E+ + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 262 bits (643), Expect = 7e-70
Identities = 133/210 (63%), Positives = 158/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W KPIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 262 bits (643), Expect = 7e-70
Identities = 133/210 (63%), Positives = 158/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W KPIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 262 bits (643), Expect = 7e-70
Identities = 133/210 (63%), Positives = 158/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W KPIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 262 bits (643), Expect = 7e-70
Identities = 133/210 (63%), Positives = 158/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W KPIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 53.6 bits (123), Expect = 7e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKIYDG 221
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 262 bits (643), Expect = 7e-70
Identities = 133/210 (63%), Positives = 158/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W KPIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 262 bits (641), Expect = 1e-69
Identities = 132/210 (62%), Positives = 159/210 (75%), Gaps = 5/210 (2%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI+P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCP-----RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*H 598
W +PIIIGRHA+ DQY+ATDF P Y+ ++ + + +G V
Sbjct: 124 WVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKV---TYLVHNFEEGGGV-A 179
Query: 599 WAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 180 MGMYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 262 bits (641), Expect = 1e-69
Identities = 133/208 (63%), Positives = 156/208 (75%), Gaps = 3/208 (1%)
Frame = +2
Query: 74 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 253
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 254 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 433
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 434 WDKPIIIGRHAHADQYKATDFCCPRCWYS*NNLQT*IW*GNKTCSS*V---QGCXV*HWA 604
W KPIIIGRHA+ DQY+ATDF P + G + + V +G
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVPGPGKV--EITYTPSDGTQKVTYLVHNSEGGGGVAMG 181
Query: 605 MFNTDASIIDFAHSSFQVCFGQKIPSVL 688
M+N D SI DFAHSSFQ+ + P L
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKGWPLYL 209
Score = 56.0 bits (129), Expect = 1e-07
Identities = 29/78 (37%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH +G F+ AL +
Sbjct: 144 FVVPGPGKVEITYTPSDGTQKVTYLVHNSEGGGGVAMGMYNQDKSIEDFAHSSFQMALSK 203
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 204 GWPLYLSTKNTILKKYDG 221
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 250 bits (613), Expect = 3e-66
Identities = 131/212 (61%), Positives = 145/212 (68%), Gaps = 1/212 (0%)
Frame = +2
Query: 47 YSRHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTD 223
+ R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TD
Sbjct: 34 HPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTD 93
Query: 224 DQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAII 403
DQVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE II
Sbjct: 94 DQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPII 153
Query: 404 CKNIPRLVTGWDKPIIIGRHAHADQYKATDFCCPRCWYS*NNLQT*IW*GNKTCSS*VQG 583
CKNIPRLV GW KPI IGRHAH DQYKATDF R G K
Sbjct: 154 CKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP 213
Query: 584 CXV*HWAMFNTDASIIDFAHSSFQVCFGQKIP 679
M+NTD SI FAHS FQ +K P
Sbjct: 214 AGGVGMGMYNTDESISGFAHSCFQYAIQKKWP 245
Score = 48.8 bits (111), Expect = 2e-05
Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 1/82 (1%)
Frame = +3
Query: 483 KQLTFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKF 659
K FV AGT +++F P+ G +K V+ + F++
Sbjct: 180 KATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC-FQY 238
Query: 660 ALDRKYPLYLSTKNTILXNYEG 725
A+ +K+PLY+STKNTIL Y+G
Sbjct: 239 AIQKKWPLYMSTKNTILKAYDG 260
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 250 bits (612), Expect = 4e-66
Identities = 131/210 (62%), Positives = 144/210 (68%), Gaps = 1/210 (0%)
Frame = +2
Query: 53 RHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQ 229
R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 230 VTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICK 409
VTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICK
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 410 NIPRLVTGWDKPIIIGRHAHADQYKATDFCCPRCWYS*NNLQT*IW*GNKTCSS*VQGCX 589
NIPRLV GW KPI IGRHAH DQYKATDF R G K
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAG 215
Query: 590 V*HWAMFNTDASIIDFAHSSFQVCFGQKIP 679
M+NTD SI FAHS FQ +K P
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWP 245
Score = 48.8 bits (111), Expect = 2e-05
Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 1/82 (1%)
Frame = +3
Query: 483 KQLTFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKF 659
K FV AGT +++F P+ G +K V+ + F++
Sbjct: 180 KATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC-FQY 238
Query: 660 ALDRKYPLYLSTKNTILXNYEG 725
A+ +K+PLY+STKNTIL Y+G
Sbjct: 239 AIQKKWPLYMSTKNTILKAYDG 260
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 250 bits (612), Expect = 4e-66
Identities = 131/210 (62%), Positives = 144/210 (68%), Gaps = 1/210 (0%)
Frame = +2
Query: 53 RHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQ 229
R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 230 VTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICK 409
VTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICK
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 410 NIPRLVTGWDKPIIIGRHAHADQYKATDFCCPRCWYS*NNLQT*IW*GNKTCSS*VQGCX 589
NIPRLV GW KPI IGRHAH DQYKATDF R G K
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAG 215
Query: 590 V*HWAMFNTDASIIDFAHSSFQVCFGQKIP 679
M+NTD SI FAHS FQ +K P
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWP 245
Score = 48.8 bits (111), Expect = 2e-05
Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 1/82 (1%)
Frame = +3
Query: 483 KQLTFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKF 659
K FV AGT +++F P+ G +K V+ + F++
Sbjct: 180 KATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC-FQY 238
Query: 660 ALDRKYPLYLSTKNTILXNYEG 725
A+ +K+PLY+STKNTIL Y+G
Sbjct: 239 AIQKKWPLYMSTKNTILKAYDG 260
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 250 bits (612), Expect = 4e-66
Identities = 131/210 (62%), Positives = 144/210 (68%), Gaps = 1/210 (0%)
Frame = +2
Query: 53 RHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQ 229
R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 230 VTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICK 409
VTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICK
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 410 NIPRLVTGWDKPIIIGRHAHADQYKATDFCCPRCWYS*NNLQT*IW*GNKTCSS*VQGCX 589
NIPRLV GW KPI IGRHAH DQYKATDF R G K
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAG 215
Query: 590 V*HWAMFNTDASIIDFAHSSFQVCFGQKIP 679
M+NTD SI FAHS FQ +K P
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWP 245
Score = 48.8 bits (111), Expect = 2e-05
Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 1/82 (1%)
Frame = +3
Query: 483 KQLTFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKF 659
K FV AGT +++F P+ G +K V+ + F++
Sbjct: 180 KATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC-FQY 238
Query: 660 ALDRKYPLYLSTKNTILXNYEG 725
A+ +K+PLY+STKNTIL Y+G
Sbjct: 239 AIQKKWPLYMSTKNTILKAYDG 260
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 223 bits (544), Expect = 7e-58
Identities = 114/184 (61%), Positives = 136/184 (73%), Gaps = 5/184 (2%)
Frame = +2
Query: 152 LILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLK 331
LI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCATITPDEKRVEEFKLK
Sbjct: 1 LIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLK 60
Query: 332 KMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFCCP-- 505
+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDF P
Sbjct: 61 QMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGP 120
Query: 506 ---RCWYS*NNLQT*IW*GNKTCSS*VQGCXV*HWAMFNTDASIIDFAHSSFQVCFGQKI 676
Y+ ++ + + +G V M+N D SI DFAHSSFQ+ +
Sbjct: 121 GKVEITYTPSDGTQKV---TYLVHNFEEGGGV-AMGMYNQDKSIEDFAHSSFQMALSKGW 176
Query: 677 PSVL 688
P L
Sbjct: 177 PLYL 180
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 115 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 174
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 175 GWPLYLSTKNTILKKYDG 192
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 203 bits (496), Expect = 5e-52
Identities = 105/171 (61%), Positives = 115/171 (67%)
Frame = +2
Query: 167 LDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKS 346
LD++L +DLG+ NRD+TDDQVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKS
Sbjct: 42 LDVQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS 101
Query: 347 PNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFCCPRCWYS*N 526
PNGTIRNI GGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDF R
Sbjct: 102 PNGTIRNIHGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKM 161
Query: 527 NLQT*IW*GNKTCSS*VQGCXV*HWAMFNTDASIIDFAHSSFQVCFGQKIP 679
G K M+NTD SI FAHS FQ +K P
Sbjct: 162 VFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWP 212
Score = 48.8 bits (111), Expect = 2e-05
Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 1/82 (1%)
Frame = +3
Query: 483 KQLTFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKF 659
K FV AGT +++F P+ G +K V+ + F++
Sbjct: 147 KATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC-FQY 205
Query: 660 ALDRKYPLYLSTKNTILXNYEG 725
A+ +K+PLY+STKNTIL Y+G
Sbjct: 206 AIQKKWPLYMSTKNTILKAYDG 227
>U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic
NADP-dependent isocitrate dehydrogenase protein.
Length = 154
Score = 97.9 bits (233), Expect = 3e-20
Identities = 58/114 (50%), Positives = 70/114 (61%), Gaps = 5/114 (4%)
Frame = +2
Query: 362 RNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFCCP-----RCWYS*N 526
RNILGGTVF EAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDF P Y+ +
Sbjct: 1 RNILGGTVFXEAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS 60
Query: 527 NLQT*IW*GNKTCSS*VQGCXV*HWAMFNTDASIIDFAHSSFQVCFGQKIPSVL 688
+ + + +G V M+N D SI DFAHSSFQ+ + P L
Sbjct: 61 DGTQKV---TYLVHNFEEGGGV-AMGMYNQDKSIEDFAHSSFQMALSKGWPLYL 110
Score = 54.8 bits (126), Expect = 3e-07
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Frame = +3
Query: 495 FVVPGAGTLEIIFKPESG-EAIKHVVHEYKGAXCSXXXXXXXXXXXXXXXXXHFKFALDR 671
FVVPG G +EI + P G + + ++VH ++ F+ AL +
Sbjct: 45 FVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSK 104
Query: 672 KYPLYLSTKNTILXNYEG 725
+PLYLSTKNTIL Y+G
Sbjct: 105 GWPLYLSTKNTILKKYDG 122
>BC026231-1|AAH26231.1| 322|Homo sapiens lymphatic vessel
endothelial hyaluronan receptor 1 protein.
Length = 322
Score = 30.3 bits (65), Expect = 7.7
Identities = 23/67 (34%), Positives = 28/67 (41%), Gaps = 1/67 (1%)
Frame = -3
Query: 565 TCFIASPDSGLKIISRV-PAPGTTKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNSLP 389
TC G +ISR+ P P K VLI S F CY S N+ +P
Sbjct: 84 TCSYGWVGDGFVVISRISPNPKCGKNGVGVLIRKVPVSRQ--FAAYCYNSSDTWTNSCIP 141
Query: 388 ENSTTKN 368
E TTK+
Sbjct: 142 EIITTKD 148
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 102,988,509
Number of Sequences: 237096
Number of extensions: 2159554
Number of successful extensions: 3693
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 3539
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3661
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 9015132854
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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