Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-1755
(700 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
D87442-1|BAA13383.1| 708|Homo sapiens KIAA0253 protein. 54 5e-07
BC047621-1|AAH47621.1| 689|Homo sapiens NCSTN protein protein. 54 5e-07
AY359120-1|AAQ89478.1| 709|Homo sapiens ATAG1874 protein. 54 5e-07
AL445230-7|CAI15010.1| 689|Homo sapiens nicastrin protein. 54 5e-07
AL445230-6|CAI15009.1| 709|Homo sapiens nicastrin protein. 54 5e-07
AF240468-1|AAG11412.1| 709|Homo sapiens nicastrin protein. 54 5e-07
AL445230-10|CAI15013.1| 274|Homo sapiens nicastrin protein. 44 4e-04
AL445230-8|CAI15011.1| 319|Homo sapiens nicastrin protein. 41 0.004
AL445230-9|CAI15012.1| 219|Homo sapiens nicastrin protein. 41 0.005
BC030275-1|AAH30275.1| 965|Homo sapiens vacuolar protein sortin... 30 6.9
AY444798-1|AAS20945.1| 977|Homo sapiens vacuolar sorting protei... 30 6.9
AF102177-1|AAF37319.1| 966|Homo sapiens tumor antigen SLP-8p pr... 30 6.9
>D87442-1|BAA13383.1| 708|Homo sapiens KIAA0253 protein.
Length = 708
Score = 54.0 bits (124), Expect = 5e-07
Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 3/219 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G +P +V VE+GQ+ S + +T P++
Sbjct: 336 YIGSSRMVYDMEKGKFPVQLE----NVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 386
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 387 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRA-RNI--SG----VV 439
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMINNVTFISTAELIADGLMKETDTQVKI 532
L DH F N +Y S D ++ I +Y +S ++ F+ TDT +
Sbjct: 440 LADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV-------------TDTAKAL 486
Query: 533 SRLATALAHALYQRVVGEAYTGNITVSAHLVDEMLYCFL 649
+ +AT L ALY+ G ++ + V +LY FL
Sbjct: 487 ADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFL 525
>BC047621-1|AAH47621.1| 689|Homo sapiens NCSTN protein protein.
Length = 689
Score = 54.0 bits (124), Expect = 5e-07
Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 3/219 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G +P +V VE+GQ+ S + +T P++
Sbjct: 317 YIGSSRMVYDMEKGKFPVQLE----NVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 367
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 368 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRA-RNI--SG----VV 420
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMINNVTFISTAELIADGLMKETDTQVKI 532
L DH F N +Y S D ++ I +Y +S ++ F+ TDT +
Sbjct: 421 LADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV-------------TDTAKAL 467
Query: 533 SRLATALAHALYQRVVGEAYTGNITVSAHLVDEMLYCFL 649
+ +AT L ALY+ G ++ + V +LY FL
Sbjct: 468 ADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFL 506
>AY359120-1|AAQ89478.1| 709|Homo sapiens ATAG1874 protein.
Length = 709
Score = 54.0 bits (124), Expect = 5e-07
Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 3/219 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G +P +V VE+GQ+ S + +T P++
Sbjct: 337 YIGSSRMVYDMEKGKFPVQLE----NVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 387
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 388 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRA-RNI--SG----VV 440
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMINNVTFISTAELIADGLMKETDTQVKI 532
L DH F N +Y S D ++ I +Y +S ++ F+ TDT +
Sbjct: 441 LADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV-------------TDTAKAL 487
Query: 533 SRLATALAHALYQRVVGEAYTGNITVSAHLVDEMLYCFL 649
+ +AT L ALY+ G ++ + V +LY FL
Sbjct: 488 ADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFL 526
>AL445230-7|CAI15010.1| 689|Homo sapiens nicastrin protein.
Length = 689
Score = 54.0 bits (124), Expect = 5e-07
Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 3/219 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G +P +V VE+GQ+ S + +T P++
Sbjct: 317 YIGSSRMVYDMEKGKFPVQLE----NVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 367
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 368 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRA-RNI--SG----VV 420
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMINNVTFISTAELIADGLMKETDTQVKI 532
L DH F N +Y S D ++ I +Y +S ++ F+ TDT +
Sbjct: 421 LADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV-------------TDTAKAL 467
Query: 533 SRLATALAHALYQRVVGEAYTGNITVSAHLVDEMLYCFL 649
+ +AT L ALY+ G ++ + V +LY FL
Sbjct: 468 ADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFL 506
>AL445230-6|CAI15009.1| 709|Homo sapiens nicastrin protein.
Length = 709
Score = 54.0 bits (124), Expect = 5e-07
Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 3/219 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G +P +V VE+GQ+ S + +T P++
Sbjct: 337 YIGSSRMVYDMEKGKFPVQLE----NVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 387
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 388 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRA-RNI--SG----VV 440
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMINNVTFISTAELIADGLMKETDTQVKI 532
L DH F N +Y S D ++ I +Y +S ++ F+ TDT +
Sbjct: 441 LADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV-------------TDTAKAL 487
Query: 533 SRLATALAHALYQRVVGEAYTGNITVSAHLVDEMLYCFL 649
+ +AT L ALY+ G ++ + V +LY FL
Sbjct: 488 ADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFL 526
>AF240468-1|AAG11412.1| 709|Homo sapiens nicastrin protein.
Length = 709
Score = 54.0 bits (124), Expect = 5e-07
Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 3/219 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G +P +V VE+GQ+ S + +T P++
Sbjct: 337 YIGSSRMVYDMEKGKFPVQLE----NVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 387
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 388 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRA-RNI--SG----VV 440
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMINNVTFISTAELIADGLMKETDTQVKI 532
L DH F N +Y S D ++ I +Y +S ++ F+ TDT +
Sbjct: 441 LADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV-------------TDTAKAL 487
Query: 533 SRLATALAHALYQRVVGEAYTGNITVSAHLVDEMLYCFL 649
+ +AT L ALY+ G ++ + V +LY FL
Sbjct: 488 ADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFL 526
>AL445230-10|CAI15013.1| 274|Homo sapiens nicastrin protein.
Length = 274
Score = 44.4 bits (100), Expect = 4e-04
Identities = 37/125 (29%), Positives = 57/125 (45%), Gaps = 1/125 (0%)
Frame = +2
Query: 278 LPPSSIHSFRRILSNVTESGEMLEMLLVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMI 454
LPPSS+ F R N+ SG ++L DH F N +Y S D ++ I +Y +S
Sbjct: 98 LPPSSLQRFLRA-RNI--SG----VVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPE 150
Query: 455 NNVTFISTAELIADGLMKETDTQVKISRLATALAHALYQRVVGEAYTGNITVSAHLVDEM 634
++ F+ TDT ++ +AT L ALY+ G ++ + V +
Sbjct: 151 EDLNFV-------------TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRL 197
Query: 635 LYCFL 649
LY FL
Sbjct: 198 LYGFL 202
>AL445230-8|CAI15011.1| 319|Homo sapiens nicastrin protein.
Length = 319
Score = 41.1 bits (92), Expect = 0.004
Identities = 44/161 (27%), Positives = 76/161 (47%), Gaps = 3/161 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G + P+ +V VE+GQ+ S + +T P++
Sbjct: 172 YIGSSRMVYDMEKGKF----PVQLENVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 222
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 223 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLR-ARNI--SG----VV 275
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAYKN-ISMINNVTFIS 475
L DH F N +Y S D ++ I +Y +S ++ F++
Sbjct: 276 LADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT 316
>AL445230-9|CAI15012.1| 219|Homo sapiens nicastrin protein.
Length = 219
Score = 40.7 bits (91), Expect = 0.005
Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 2/147 (1%)
Frame = +2
Query: 2 YIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAP 181
YIGS R+ YD+++G + P+ +V VE+GQ+ S + +T P++
Sbjct: 81 YIGSSRMVYDMEKGKF----PVQLENVDSFVELGQVALRTSLELWMHTDPVSQ-----KN 131
Query: 182 STINDGDNDIQIFLKQLSNAYNMTIPGIFNGS--LPPSSIHSFRRILSNVTESGEMLEML 355
++ + D+ L++ I N S LPPSS+ F R N+ SG ++
Sbjct: 132 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLR-ARNI--SG----VV 184
Query: 356 LVDHKETFTNVFYNSALDDSDKIAYAY 436
L DH F N +Y S D ++ I +Y
Sbjct: 185 LADHSGAFHNKYYQSIYDTAENINVSY 211
>BC030275-1|AAH30275.1| 965|Homo sapiens vacuolar protein sorting
54 homolog (S. cerevisiae) protein.
Length = 965
Score = 30.3 bits (65), Expect = 6.9
Identities = 13/54 (24%), Positives = 31/54 (57%)
Frame = +2
Query: 293 IHSFRRILSNVTESGEMLEMLLVDHKETFTNVFYNSALDDSDKIAYAYKNISMI 454
IHSFR + S + E ++++ +++ T+++ N L+D ++ + IS++
Sbjct: 321 IHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEDDCQVLEEERLISLV 374
>AY444798-1|AAS20945.1| 977|Homo sapiens vacuolar sorting protein
54 long isoform protein.
Length = 977
Score = 30.3 bits (65), Expect = 6.9
Identities = 13/54 (24%), Positives = 31/54 (57%)
Frame = +2
Query: 293 IHSFRRILSNVTESGEMLEMLLVDHKETFTNVFYNSALDDSDKIAYAYKNISMI 454
IHSFR + S + E ++++ +++ T+++ N L+D ++ + IS++
Sbjct: 333 IHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEDDCQVLEEERLISLV 386
>AF102177-1|AAF37319.1| 966|Homo sapiens tumor antigen SLP-8p
protein.
Length = 966
Score = 30.3 bits (65), Expect = 6.9
Identities = 13/54 (24%), Positives = 31/54 (57%)
Frame = +2
Query: 293 IHSFRRILSNVTESGEMLEMLLVDHKETFTNVFYNSALDDSDKIAYAYKNISMI 454
IHSFR + S + E ++++ +++ T+++ N L+D ++ + IS++
Sbjct: 333 IHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEDDCQVLEEERLISLV 386
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 106,160,721
Number of Sequences: 237096
Number of extensions: 2387301
Number of successful extensions: 3948
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 3753
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3942
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8063224416
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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