Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-0422
(700 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 250 3e-65
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 187 3e-46
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 153 5e-36
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 147 2e-34
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 146 3e-34
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 146 6e-34
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 141 1e-32
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 140 2e-32
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 139 7e-32
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 136 4e-31
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 134 2e-30
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 130 2e-29
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 128 2e-28
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 117 3e-25
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 115 1e-24
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 110 3e-23
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 107 3e-22
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 99 9e-20
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 94 3e-18
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 94 3e-18
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 91 2e-17
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 86 7e-16
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 85 2e-15
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 83 5e-15
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 82 1e-14
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 82 1e-14
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 80 6e-14
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 77 4e-13
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 74 3e-12
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 74 4e-12
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 73 9e-12
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 71 3e-11
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 70 6e-11
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 66 6e-10
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 66 6e-10
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 66 1e-09
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 57 4e-07
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 57 5e-07
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 56 6e-07
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 56 6e-07
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 55 2e-06
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 53 8e-06
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 53 8e-06
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 53 8e-06
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 52 1e-05
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 52 1e-05
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 52 1e-05
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 50 4e-05
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 49 1e-04
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 49 1e-04
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 48 2e-04
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 48 3e-04
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 40 3e-04
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 47 4e-04
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 47 5e-04
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 46 7e-04
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 46 9e-04
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 46 9e-04
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 46 0.001
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 45 0.002
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 44 0.003
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 44 0.004
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 42 0.011
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 42 0.015
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 42 0.019
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 40 0.078
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 40 0.078
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 40 0.078
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 39 0.10
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 38 0.18
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 37 0.41
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 36 0.72
UniRef50_Q973N4 Cluster: Putative uncharacterized protein ST0866... 36 1.3
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 35 1.7
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 35 1.7
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 35 1.7
UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 34 2.9
UniRef50_Q0M010 Cluster: FAD dependent oxidoreductase; n=9; Prot... 34 3.9
UniRef50_A5E2P5 Cluster: Putative uncharacterized protein; n=1; ... 33 5.1
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 33 6.7
UniRef50_UPI0000E4A693 Cluster: PREDICTED: similar to ENSANGP000... 33 8.9
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 33 8.9
UniRef50_Q5D2M8 Cluster: Eisenstasin II; n=1; Eisenia andrei|Rep... 33 8.9
UniRef50_Q6ZV79 Cluster: CDNA FLJ42904 fis, clone BRHIP3013897; ... 33 8.9
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 250 bits (611), Expect = 3e-65
Identities = 118/175 (67%), Positives = 135/175 (77%)
Frame = +1
Query: 175 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVV 354
P A R CTLIPGDGVGPELV +QEVFK+A +P DFE +F SEVNP LSA LEDV+
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAKLEDVI 91
Query: 355 NSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDC 534
SI NK+CIKG+L TPD+S+ GELQ+LNM LR LDLYANVVH +SLP VK + D+D
Sbjct: 92 ASIRKNKVCIKGVLATPDYSNVGELQSLNMKLRNELDLYANVVHARSLPGVKTRYQDIDI 151
Query: 535 XIITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
+I EQTEG YSALEHESVPG+ ECLKIITA KS RIAK AFDY +K RK VT+
Sbjct: 152 VVIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTS 206
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 187 bits (455), Expect = 3e-46
Identities = 95/171 (55%), Positives = 119/171 (69%), Gaps = 1/171 (0%)
Frame = +1
Query: 190 EGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEV-NPTLSAPLEDVVNSIA 366
EG T++PGDGVGPEL++AV+EVFKAA++P +F+ SEV N LE V++S+
Sbjct: 46 EGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 105
Query: 367 VNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIIT 546
NK+ I G + TP + GEL + +M LR LDL+ANVVHVKSLP H ++D II
Sbjct: 106 ENKVAIIGKIHTP-MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164
Query: 547 EQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
EQTEG YS+LEHES GV ECLKI+T +KS+RIAK AFDY K GR VTA
Sbjct: 165 EQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTA 215
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 153 bits (370), Expect = 5e-36
Identities = 86/180 (47%), Positives = 114/180 (63%), Gaps = 3/180 (1%)
Frame = +1
Query: 169 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLED 348
+ P A GR T+IPGDG+GPEL+ V+ VF+ A +P DFE EV+ + +A ED
Sbjct: 45 IPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSSNADEED 99
Query: 349 VVNSIAV---NKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXH 519
+ N+I N++ +KG + T + + ++ N LR +LDLYANV+H KSLP V H
Sbjct: 100 IRNAIMAIRRNRVALKGNIET-NHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRH 158
Query: 520 XDVDCXIITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
D+D I+ E TEG YS+LEHESV GV E LKIIT +KS RIA+ AF + GRK VTA
Sbjct: 159 KDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTA 218
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 147 bits (357), Expect = 2e-34
Identities = 82/200 (41%), Positives = 116/200 (58%), Gaps = 4/200 (2%)
Frame = +1
Query: 112 VHTSSVTTEKNVCYAPFGALQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXD 291
V + +KN+ Y P + P A GR TLIPGDG+GPE+V AVQ++F+ +P D
Sbjct: 23 VRAAPQVIKKNLAYHPHH-VPPPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVD 81
Query: 292 FESFFFSEVN----PTLSAPLEDVVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXA 459
FE S ++ + + + SI N + +KG + TP + G ++LN+ LR
Sbjct: 82 FEELNLSGLDIKDEDSYLGAFNEAITSIKRNGVAMKGNIFTPLDAIPG-FRSLNLELRVH 140
Query: 460 LDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXECLKIITASKSE 639
LDL+AN+V KS+P ++ H +VD II + TEG YS LEHE+V GV E LK+ T
Sbjct: 141 LDLFANIVRCKSIPGIQTRHNNVDLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACM 200
Query: 640 RIAKXAFDYTVKMGRKXVTA 699
+IA+ AFD+ K RK VTA
Sbjct: 201 KIAQYAFDFAEKHDRKKVTA 220
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 146 bits (355), Expect = 3e-34
Identities = 82/169 (48%), Positives = 109/169 (64%)
Frame = +1
Query: 193 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVN 372
GR TLIPGDGVG E+ +V ++F+ +IP D+E+ S + T + ++ V S+ N
Sbjct: 28 GRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTEN--VQRAVESLKRN 85
Query: 373 KICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQ 552
K+ +KGI TP TG +LN+ LR LD++ANV KS+P VK ++D II E
Sbjct: 86 KVGLKGIWHTPA-DQTGH-GSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIREN 143
Query: 553 TEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
TEG YS LEHESVPGV E LKI+T +KSERIA+ AFD+ +K RK V A
Sbjct: 144 TEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCA 192
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 146 bits (353), Expect = 6e-34
Identities = 80/169 (47%), Positives = 106/169 (62%)
Frame = +1
Query: 193 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVN 372
GR TLIPGDGVG E+ +V+ +F+A +IP D+E+ + + + + V S+ N
Sbjct: 27 GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDH--KEGVYEAVESLKRN 84
Query: 373 KICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQ 552
KI +KG+ TP TG +LN+ LR LD+YANV KSL VK D+D +I E
Sbjct: 85 KIGLKGLWHTPA-DQTGH-GSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIREN 142
Query: 553 TEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
TEG +S LEHESVPGV E LK++T K+ERIA+ AFD+ K RK VTA
Sbjct: 143 TEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTA 191
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 141 bits (342), Expect = 1e-32
Identities = 89/200 (44%), Positives = 117/200 (58%), Gaps = 1/200 (0%)
Frame = +1
Query: 103 GKGVHTSSVTTEKNVCYAPF-GALQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAAS 279
G G+ T SVT Y P G PRA TLIPGDG+GP + AV++V +A
Sbjct: 18 GSGIQTRSVT------YMPRPGDGAPRAV-------TLIPGDGIGPLVTNAVEQVMEAMH 64
Query: 280 IPXDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXA 459
P FE + +V+ +S +V+ SI NK+C+KG L TP G + +LN+ LR
Sbjct: 65 APIFFEKY---DVHGEMSRVPPEVMESIRKNKVCLKGGLKTPV---GGGVSSLNVQLRKE 118
Query: 460 LDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXECLKIITASKSE 639
LDL+A++V+ +LP + H +VD +I E TEG Y+ LEHE VPGV E LK+IT SE
Sbjct: 119 LDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSE 178
Query: 640 RIAKXAFDYTVKMGRKXVTA 699
RIAK AF+Y RK VTA
Sbjct: 179 RIAKYAFEYAYLNNRKKVTA 198
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 140 bits (340), Expect = 2e-32
Identities = 76/164 (46%), Positives = 103/164 (62%)
Frame = +1
Query: 208 TLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIK 387
TLIPGDG+GP + AV++V +A P FE + EV + E+V+ S+ NK+C+K
Sbjct: 42 TLIPGDGIGPLVTGAVEQVMEAMHAPVHFERY---EVLGNMRKVPEEVIESVKRNKVCLK 98
Query: 388 GILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXY 567
G L TP G + +LNM LR LD++A++V+ ++P + H +VD +I E TEG Y
Sbjct: 99 GGLATPV---GGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEY 155
Query: 568 SALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
S LEHE VPGV E LK+IT SERIA+ AF+Y RK VTA
Sbjct: 156 SGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTA 199
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 139 bits (336), Expect = 7e-32
Identities = 72/140 (51%), Positives = 93/140 (66%), Gaps = 1/140 (0%)
Frame = +1
Query: 190 EGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEV-NPTLSAPLEDVVNSIA 366
EG T++PGDGVGPEL++AV+EVFKAA++P +F+ SEV N LE V++S+
Sbjct: 46 EGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 105
Query: 367 VNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIIT 546
NK+ I G + TP + GEL + +M LR LDL+ANVVHVKSLP H ++D II
Sbjct: 106 ENKVAIIGKIHTP-MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164
Query: 547 EQTEGXYSALEHESVPGVXE 606
EQTEG YS+LEHE V E
Sbjct: 165 EQTEGEYSSLEHECCEEVAE 184
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 136 bits (330), Expect = 4e-31
Identities = 70/176 (39%), Positives = 105/176 (59%), Gaps = 2/176 (1%)
Frame = +1
Query: 175 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSA--PLED 348
P A GR T++PG G+GPEL+ V+E+F+ P DFE +++P+ L+
Sbjct: 50 PSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVI---DIDPSTEGNDDLDY 106
Query: 349 VVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDV 528
+ SI N + +KG + T S T E+ N+ +R LDLY NVVH KS P + H D+
Sbjct: 107 AITSIKRNGVALKGNIETKSQSLT-EVSR-NVAIRNELDLYVNVVHCKSYPGIPARHHDI 164
Query: 529 DCXIITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
D +I + T+G Y+ LEHESVPG+ E +K++T +ER+A+ AF++ + RK VT
Sbjct: 165 DVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQNNRKKVT 220
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 134 bits (324), Expect = 2e-30
Identities = 79/169 (46%), Positives = 104/169 (61%), Gaps = 2/169 (1%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAASIPXDF-ESFFFSEVNPTLSAPLE-DVVNSIAVN 372
IK TL PGDG+GPE+ +V++VF AA + D+ E F +EV+P ++ L D + S+ N
Sbjct: 44 IKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKN 103
Query: 373 KICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQ 552
K+ +KG + TP G ++LN+ LR L+LYANV SLP K + DVD I E
Sbjct: 104 KVGLKGPMATP--IGKGH-RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIREN 160
Query: 553 TEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
TEG YS LEH+ V GV E LKIIT S R+A+ AF Y GRK V+A
Sbjct: 161 TEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSA 209
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 130 bits (315), Expect = 2e-29
Identities = 72/176 (40%), Positives = 103/176 (58%), Gaps = 2/176 (1%)
Frame = +1
Query: 175 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSA--PLED 348
P+A GR T++PG G+GPEL+ V+EVF+ A +P DFE +++P LE
Sbjct: 42 PKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVV---DIDPASEGNDDLEY 98
Query: 349 VVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDV 528
+ SI N + +KG + T + TG + N+ LR LDLY NV+H KS + H +V
Sbjct: 99 AITSIKRNGVALKGNIETKSEA-TGIISR-NVALRNELDLYVNVLHCKSFNAIPAHHQNV 156
Query: 529 DCXIITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
D II + TEG Y+ LEHESV GV E +K++T + R+A+ AF++ RK VT
Sbjct: 157 DVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFARANNRKKVT 212
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 128 bits (308), Expect = 2e-28
Identities = 72/166 (43%), Positives = 98/166 (59%), Gaps = 2/166 (1%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFF-SEVNPTLSAPLEDVVN-SIAVNK 375
K TLIPGDG+GPE+ A V +A + ++ESF +E + +N SI +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 376 ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQT 555
I +KG +TTP G ++N+ LR +LYANV +++LP V + VD ++ E T
Sbjct: 64 IGLKGPVTTPI---GGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENT 120
Query: 556 EGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXV 693
EG YS +EHE VPGV E LKIIT S RI+K AF+Y KMGRK +
Sbjct: 121 EGLYSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKI 166
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 117 bits (281), Expect = 3e-25
Identities = 66/169 (39%), Positives = 98/169 (57%), Gaps = 2/169 (1%)
Frame = +1
Query: 193 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSE--VNPTLSAPLEDVVNSIA 366
G+ + I GDG+GPE+ +V+++F AA++P ++ES S VN + P + V SI
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIP-DPAVQSIT 93
Query: 367 VNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIIT 546
N + +KG L TP G ++LN+ LR L+ANV KS+ K + +VD +I
Sbjct: 94 KNLVALKGPLATP--IGKGH-RSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIR 150
Query: 547 EQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXV 693
E TEG YS +EH PGV + +K+IT SER+ + AF+Y +GR V
Sbjct: 151 ENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRV 199
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 115 bits (276), Expect = 1e-24
Identities = 67/169 (39%), Positives = 97/169 (57%), Gaps = 3/169 (1%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEV---NPTLSAPLEDVVNSIAVN 372
+ TLIPGDG+GPE+ +VQ++F+AA P ++ + V + P + + N
Sbjct: 26 RVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSR-CIELMHAN 84
Query: 373 KICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQ 552
K+ +KG L TP G ++LN+ +R LYANV +SL K + +VD I E
Sbjct: 85 KVGLKGPLETP--IGKGH-RSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIREN 141
Query: 553 TEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
TEG YS +EHE VPGV + +K+IT + S +A AF+Y + GRK VTA
Sbjct: 142 TEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTA 190
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 110 bits (265), Expect = 3e-23
Identities = 56/108 (51%), Positives = 75/108 (69%), Gaps = 1/108 (0%)
Frame = +1
Query: 190 EGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEV-NPTLSAPLEDVVNSIA 366
EG T++PGDGVGPEL++AV+EVFKAAS+P +F+ SEV N LE V++S+
Sbjct: 14 EGAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 73
Query: 367 VNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVK 510
NK+ I G + TP + GEL + +M LR LDL+ANV+HVKSLP V+
Sbjct: 74 ENKVAIIGKIHTP-MEYKGELASYDMRLRRKLDLFANVIHVKSLPGVQ 120
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 107 bits (256), Expect = 3e-22
Identities = 65/166 (39%), Positives = 91/166 (54%), Gaps = 2/166 (1%)
Frame = +1
Query: 208 TLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPL--EDVVNSIAVNKIC 381
TLIPGDG+GPE+ AV ++F AA P +E + + + + S+ NK+
Sbjct: 35 TLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMG 94
Query: 382 IKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEG 561
+KG L TP + G ++N+ LR DLYANV S+ K + DV+ I E TEG
Sbjct: 95 LKGPLKTPIAA--GH-PSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEG 151
Query: 562 XYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
YS +EH V GV + +K+IT S+RIA+ AF+Y R VTA
Sbjct: 152 EYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTA 197
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 99.1 bits (236), Expect = 9e-20
Identities = 49/84 (58%), Positives = 59/84 (70%)
Frame = +1
Query: 448 LRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXECLKIITA 627
L LDLYA+V+H+K+LPNV+ H DVD ++ E TEG YS LEHESV GV E LKI+T
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 628 SKSERIAKXAFDYTVKMGRKXVTA 699
+KS RIA+ AF KMG K V A
Sbjct: 62 AKSLRIAEYAFQLAQKMGCKKVMA 85
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 94.3 bits (224), Expect = 3e-18
Identities = 59/174 (33%), Positives = 93/174 (53%), Gaps = 5/174 (2%)
Frame = +1
Query: 187 KEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFE--SFFFSEVNPTLSAPL-EDVVN 357
++GR T+IPGDG+GPE V A +V +AA P +E S +++ + ++ +
Sbjct: 16 EDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIE 75
Query: 358 SIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXD--VD 531
SI ++ +KG L TP GE ++ N+ LR + YANV V+ PNV + +D
Sbjct: 76 SIRKTRVVLKGPLETP--VGYGE-KSANVTLRKLFETYANVRPVREFPNVPTPYAGRGID 132
Query: 532 CXIITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXV 693
++ E E Y+ +EH P V + LK+I+ SE+I + AF+ GRK V
Sbjct: 133 LVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKV 186
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 93.9 bits (223), Expect = 3e-18
Identities = 58/173 (33%), Positives = 94/173 (54%), Gaps = 1/173 (0%)
Frame = +1
Query: 169 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLED 348
+ P A GR TLIPGDG+GPEL+ V+E+F+ + +P DFE + + T + +
Sbjct: 41 IPPPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS-SSTSEDDISN 99
Query: 349 VVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDV 528
+ +I N + +KG + T + + ++ N LR +LDLYANV+H +SLP V+ H ++
Sbjct: 100 AIMAIRRNGVALKGNIET-NHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNI 158
Query: 529 DCXIITEQTEGXYSALEHESVPGVXECLKIITASK-SERIAKXAFDYTVKMGR 684
D II E++E E+E + L+I A ++R A D ++ R
Sbjct: 159 DIIIILEKSEFSALLAENEKIKVELLQLRIQLADVINKRRADIILDLNIEKSR 211
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 91.5 bits (217), Expect = 2e-17
Identities = 59/170 (34%), Positives = 88/170 (51%), Gaps = 4/170 (2%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSE--VNPTLSAPL-EDVVNSIAV 369
I T+ GDG+GPE++ AV V K A++P E+ E N + + ED + I
Sbjct: 5 IPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFR 64
Query: 370 NKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANV-VHVKSLPNVKCXHXDVDCXIIT 546
K +KG +TTP G ++LN+ LR L LYANV P V ++D II
Sbjct: 65 TKALLKGPVTTP---QGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIR 121
Query: 547 EQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
E E Y+ +E+ E +K+I+ S SE+I + AF+Y +K RK ++
Sbjct: 122 ENEEDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTIS 171
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 86.2 bits (204), Expect = 7e-16
Identities = 65/188 (34%), Positives = 94/188 (50%), Gaps = 22/188 (11%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFS-EVNPTLSAPLE-DVVNSIAVNK 375
+ TLIPGDG+GPE+ A+ V +A+ + ++ EV PL V+ SI +
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEAGVEVIEKYGTPLPPQVLESIRETR 63
Query: 376 ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQT 555
+ IKG + TP TG +++N+ +R LDLYAN+ KSLP +K D+D ++ E T
Sbjct: 64 VAIKGPIGTP--VGTG-FRSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENT 120
Query: 556 EGXYSALEHE-SVP-------------------GVXECLKIITASKSERIAKXAFDYTVK 675
E Y+ +E E P G +K I+ S RI K AF+Y +
Sbjct: 121 EDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYARQ 180
Query: 676 MGRKXVTA 699
GRK VTA
Sbjct: 181 NGRKKVTA 188
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 85.0 bits (201), Expect = 2e-15
Identities = 65/190 (34%), Positives = 97/190 (51%), Gaps = 24/190 (12%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFF---SEVNPTLSAPLE-DVVNSIAV 369
+ TLI GDG+GPE+ A + V A I DFE +EV PL V+ ++
Sbjct: 5 RVTLIRGDGIGPEVTQAARIVLDATGI--DFEWVVVDAGAEVMEKSGTPLPAPVIEAVRA 62
Query: 370 NKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITE 549
+ IKG +TTP S ++++N+ LR ALDLYAN+ ++LP V + ++D ++ E
Sbjct: 63 SDAAIKGPITTPAGSG---IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRE 119
Query: 550 QTEGXYSALEHE-SVPGVXE-------------------CLKIITASKSERIAKXAFDYT 669
TE YS +E E + P E +K I++ SERIA+ AF+Y
Sbjct: 120 NTEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYA 179
Query: 670 VKMGRKXVTA 699
+ R+ VTA
Sbjct: 180 RRHARRKVTA 189
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 83.4 bits (197), Expect = 5e-15
Identities = 58/165 (35%), Positives = 84/165 (50%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 381
K TLI G+GVG EL+ AVQEV A P +++ + + E V+ S+ NK+
Sbjct: 71 KVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPE-VLKSLRANKVG 129
Query: 382 IKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEG 561
IKG P S + Q +R +A V + + + D D II +Q EG
Sbjct: 130 IKG----PVDSRHWQRQ-----IRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEG 180
Query: 562 XYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
YS +EH VPGV + +K+ T + + RIA+ F+Y VK RK +T
Sbjct: 181 DYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRIT 225
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 82.2 bits (194), Expect = 1e-14
Identities = 60/182 (32%), Positives = 91/182 (50%), Gaps = 8/182 (4%)
Frame = +1
Query: 175 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPL--ED 348
P ++ + +I TLIPGDG+GPE+V V VF A P +E+ S L +
Sbjct: 2 PNSSTQQQIPVTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQT 61
Query: 349 VVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSL-PNVKCXHXD 525
++SI + +KG L+TP G +++N+ LR LYANV +++ P + +
Sbjct: 62 TLDSIGRTGLALKGPLSTP---IGGGFRSVNVRLRETFQLYANVRPARTIVPGGR--YEK 116
Query: 526 VDCXIITEQTEGXYSALEH-----ESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKX 690
+D ++ E EG Y EH + V I T + S RI+K AFDY V+ R+
Sbjct: 117 IDLVLVRENLEGLYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRK 176
Query: 691 VT 696
VT
Sbjct: 177 VT 178
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 81.8 bits (193), Expect = 1e-14
Identities = 60/170 (35%), Positives = 79/170 (46%), Gaps = 4/170 (2%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSE---VNPTLSAPLEDVVNSIAV 369
+ T+ GDGVGPE++ AV + K A E+ S SI+
Sbjct: 8 VPITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISR 67
Query: 370 NKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVH-VKSLPNVKCXHXDVDCXIIT 546
++ +K TP S G ++LN+ LR L LY NV V P V H D+D II
Sbjct: 68 TRLLLKAPTMTPQGS--GH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIR 124
Query: 547 EQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
E E YS +EH+ EC+KI T S SE+I AF+Y RK VT
Sbjct: 125 ENEEDTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVT 174
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 79.8 bits (188), Expect = 6e-14
Identities = 55/151 (36%), Positives = 78/151 (51%), Gaps = 1/151 (0%)
Frame = +1
Query: 250 AVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIKGILTTPDFSHTGEL 429
AV +V A P FE++ N ++ +VV+SI NK+C+ G +
Sbjct: 15 AVHQVMDAMQAPVYFETYIIKGKN--MNHLTWEVVDSIRKNKVCLNGRVNN--------- 63
Query: 430 QTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXEC 609
+L R LDL+A++V +L H +VD +I E TEG Y+ EHE VPGV E
Sbjct: 64 -SLCGGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIES 122
Query: 610 LKI-ITASKSERIAKXAFDYTVKMGRKXVTA 699
++ +T S+RIAK AF+Y RK VTA
Sbjct: 123 FQVTMTKFWSDRIAKYAFEYAHFSKRKKVTA 153
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 77.0 bits (181), Expect = 4e-13
Identities = 52/167 (31%), Positives = 81/167 (48%), Gaps = 4/167 (2%)
Frame = +1
Query: 208 TLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSE---VNPTLSAPLEDVVNSIAVNKI 378
T+ GDG+GPE++ AV + + A E+ E S E+ SI I
Sbjct: 8 TIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTGI 67
Query: 379 CIKGILTTPDFSHTGELQTLNMXLRXALDLYANV-VHVKSLPNVKCXHXDVDCXIITEQT 555
+K +TTP G ++LN+ +R L L+AN+ V P H ++ II E
Sbjct: 68 ILKAPITTP---QGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENE 124
Query: 556 EGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
E Y+ +E+ + E +K+I+ + E+I + AF+Y VK RK VT
Sbjct: 125 EDLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVT 171
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 74.1 bits (174), Expect = 3e-12
Identities = 54/168 (32%), Positives = 80/168 (47%), Gaps = 1/168 (0%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVNKI 378
+K +IPGDG+G E++ A + + D E F ++ A L+ ++ +
Sbjct: 4 MKIAVIPGDGIGVEVMEAALHILNTLDL--DLE-FIHADAG---DACLKRTGTALPEETL 57
Query: 379 CIKGILTTPDFSHTGELQT-LNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQT 555
G F GE + + LR DL+AN+ VKSLP V C + D+D I+ E T
Sbjct: 58 EAVGEARATLFGAAGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENT 117
Query: 556 EGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
E Y + E P +IIT + S RI++ AF Y K G + VTA
Sbjct: 118 EDLYVG-DEEYTPEGAVAKRIITRTASRRISQFAFQYAQKEGMQKVTA 164
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 73.7 bits (173), Expect = 4e-12
Identities = 55/167 (32%), Positives = 81/167 (48%), Gaps = 5/167 (2%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 378
K +I GDG+G E+V A +V +A +P +F + EV L + A++
Sbjct: 3 KICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGKALPEETIETALD-- 60
Query: 379 CIKGILTTPDFSHTGELQT-LNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQT 555
C +L F GE + + LR LD YAN+ VK+ VKC D+D I+ E T
Sbjct: 61 C-DAVL----FGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENT 115
Query: 556 EGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYT---VKMGRK 687
EG Y +E E G+ ++IT ERI + AF+ KMG++
Sbjct: 116 EGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKE 162
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 72.5 bits (170), Expect = 9e-12
Identities = 51/162 (31%), Positives = 79/162 (48%), Gaps = 5/162 (3%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAASIPXDFE-----SFFFSEVNPTLSAPLEDVVNSIAVNK 375
+I GDGVGPELV A+ +V AA +F + ++ E P ++ + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVP-DETWQILDSSD 65
Query: 376 ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQT 555
C KG TTP G +++ + +R DLYANV +K+ PN DV+ + E T
Sbjct: 66 ACFKGPTTTP--GGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGT 123
Query: 556 EGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMG 681
EG Y E + V ++ IT + S +IA+ AF+ + G
Sbjct: 124 EGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRG 165
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 70.9 bits (166), Expect = 3e-11
Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 1/167 (0%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 381
K +IPGDG+G E++ A + + +P FE ++ + L + + + + C
Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKLDLP--FEYSYYDAGDEALEKYGKALPDETL--EAC 58
Query: 382 IKGILTTPDFSHTGELQT-LNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTE 558
K F GE + + LR L +ANV K++ ++C + +D ++ E TE
Sbjct: 59 RKSDAVL--FGAAGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTE 116
Query: 559 GXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
Y E V E +++IT SERIA+ AF+ + GRK VTA
Sbjct: 117 CLYMGFEF-GFGDVTEAIRVITREASERIARYAFELAKREGRKKVTA 162
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 69.7 bits (163), Expect = 6e-11
Identities = 35/79 (44%), Positives = 49/79 (62%)
Frame = +1
Query: 463 DLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXECLKIITASKSER 642
DL ANVV +S P V+ H ++D ++ + TEG YS LE ES+ V E L+ +T +K R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 643 IAKXAFDYTVKMGRKXVTA 699
+A+ AF +MG K VTA
Sbjct: 77 LAEYAFQLAHRMGCKKVTA 95
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 66.5 bits (155), Expect = 6e-10
Identities = 45/133 (33%), Positives = 70/133 (52%), Gaps = 4/133 (3%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 378
K TLIPGDGVGPE+ A ++ A + D++ EV + V++SI NKI
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANKI 62
Query: 379 CIKGILTTPDFSHTGE-LQTLNMXLRXALDLYANVVHVKSLPNVKCXHXD--VDCXIITE 549
+K +TTP G+ +++N+ LR L LYA + K+ V+ D VD ++ E
Sbjct: 63 ALKAPITTP----IGKGFRSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRE 118
Query: 550 QTEGXYSALEHES 588
TE Y+ +E ++
Sbjct: 119 NTEDLYAGVEFQA 131
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 66.5 bits (155), Expect = 6e-10
Identities = 57/173 (32%), Positives = 83/173 (47%), Gaps = 8/173 (4%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFE------SFFFSEVNPTLSAPLEDVVNSI 363
K +LI GDG+GPEL + V + D + S + T A +D V++I
Sbjct: 3 KISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSAI 62
Query: 364 AVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXII 543
+ C+K P ++ + LR LDLYAN+ KS P++ D+D I+
Sbjct: 63 KQSDACMKA----PVGESAADVIVV---LRRMLDLYANIRPAKSYPHMPALRDDIDMVIV 115
Query: 544 TEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKM--GRKXVT 696
E TE Y+ E S+ L+II+ S+RIAK AF+ T KM +K VT
Sbjct: 116 RENTEDLYTGKEF-SLGDSSVALRIISEQASKRIAKYAFE-TAKMRNDKKKVT 166
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 65.7 bits (153), Expect = 1e-09
Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 4/166 (2%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVF----KAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVNKI 378
LI GDG+GPE+V + + + S+P ++ E A + + ++ I
Sbjct: 7 LIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEV---EAGDRALARYGEALPKDSLKII 63
Query: 379 CIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTE 558
I+ + + + LR D+YAN+ KS+P + + +VD I+ E TE
Sbjct: 64 DKADIILKGPVGESAA--DVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENTE 121
Query: 559 GXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
Y EH GV +KIIT SERIAK ++ ++ RK VT
Sbjct: 122 DLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALRR-RKKVT 166
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 57.2 bits (132), Expect = 4e-07
Identities = 27/79 (34%), Positives = 40/79 (50%)
Frame = +1
Query: 460 LDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXECLKIITASKSE 639
LDLY +S P KC VD +I + G ++ LE+ V GV E L +++ ++
Sbjct: 138 LDLYVFKTRTRSFPGFKCRFPGVDIQLIGQNNMGIFNELEYSPVEGVVEALSVVSQKGND 197
Query: 640 RIAKXAFDYTVKMGRKXVT 696
+ + AF K GRK VT
Sbjct: 198 KYLRYAFKAAAKAGRKRVT 216
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 56.8 bits (131), Expect = 5e-07
Identities = 48/149 (32%), Positives = 73/149 (48%), Gaps = 9/149 (6%)
Frame = +1
Query: 220 GDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPL------EDVVNSIAVNKIC 381
GDG+G ++V A V AA+ E +F + L +D +N+I ++
Sbjct: 35 GDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNYLPDDTLNAIKEFRVA 94
Query: 382 IKGILTTPDFSHTGELQTLNMXLRXALDLYAN---VVHVKSLPNVKCXHXDVDCXIITEQ 552
+KG LTTP G ++LN+ +R LDLYAN V ++K +P+ V+ I E
Sbjct: 95 LKGPLTTPV---GGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFREN 151
Query: 553 TEGXYSALEHESVPGVXECLKIITASKSE 639
TE Y+ +E G E LK+I K+E
Sbjct: 152 TEDVYAGIEWPR--GSEEALKLIRFLKNE 178
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 56.4 bits (130), Expect = 6e-07
Identities = 31/76 (40%), Positives = 46/76 (60%), Gaps = 3/76 (3%)
Frame = +1
Query: 169 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLED 348
+ P A GR T+IPGDG+GPEL+ V+ VF+ A +P DFE EV+ + +A ED
Sbjct: 18 IPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSSNADEED 72
Query: 349 VVNSIAV---NKICIK 387
+ N+I N++ +K
Sbjct: 73 ICNAIMAIRRNRVALK 88
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 56.4 bits (130), Expect = 6e-07
Identities = 47/175 (26%), Positives = 77/175 (44%), Gaps = 13/175 (7%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTL--SAPLEDVVNSIAVNKICI 384
++ G+G+GPE+ A V +A I +++ ++ L A V+ I K CI
Sbjct: 5 VLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVKFCI 64
Query: 385 KGILTTPDF-------SHTGELQT---LNMXLRXALDLYANVVHVKSLPNVKCXHXDVDC 534
K L G + T +N +R L+L+ N ++ + H +D
Sbjct: 65 KAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEKMDM 124
Query: 535 XIITEQTEGXYSALEHESVPGVX-ECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
I+ E TE Y E G E +K +T S S ++++ AF+Y K GRK V+
Sbjct: 125 VIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVS 179
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 54.8 bits (126), Expect = 2e-06
Identities = 45/172 (26%), Positives = 74/172 (43%), Gaps = 6/172 (3%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDF-----ESFFFSEVNPTLSAPLEDVVNSIA 366
K ++ GDG+GPE+V ++ V K + + S + + ++ + DV I
Sbjct: 4 KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKIL 63
Query: 367 VNK-ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXII 543
C KG TT G +++ + LR DLYAN+ K+ + +DC
Sbjct: 64 EETDCCFKGPTTT--IPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLT-PDRKLDCVCF 120
Query: 544 TEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVTA 699
E TEG Y+ +E + ++ IT S R+ A D+ K K + A
Sbjct: 121 REATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVA 172
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 52.8 bits (121), Expect = 8e-06
Identities = 52/168 (30%), Positives = 72/168 (42%), Gaps = 13/168 (7%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSE-VNPTLSAPLEDVVNSIAVNKI--- 378
+IPGDG+GPELV + EV +AA+ D E F SE +++ + +I
Sbjct: 11 VIPGDGIGPELVRSAVEVLRAAA-GRDVELRFTSEDAGADAFRRTGSAMSAATLERIRTR 69
Query: 379 ---CIKGILTTPDFSHTG--ELQTLNMXLRXALDLYANVVHVKSLPNVKC--XHXDVDCX 537
+KG + P H E L LR LD YANV + LP V VD
Sbjct: 70 YHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVDYV 129
Query: 538 IITEQTEGXYSALEHESVPGVXECLK--IITASKSERIAKXAFDYTVK 675
I+ E TEG Y + V C ++T ER+ AF+ +
Sbjct: 130 IVRENTEGLYLS-RGRGVGNDRACADQLLMTRHGVERVVVHAFELATR 176
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 52.8 bits (121), Expect = 8e-06
Identities = 50/156 (32%), Positives = 74/156 (47%), Gaps = 2/156 (1%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFS-EVNPTLSAPL-EDVVNSIAVNK 375
+ +I GDG+GPE+V + V + + F F EV + +P+ ED + I
Sbjct: 3 RVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFEGGFEVFKRIGSPISEDDLKEIRKMD 62
Query: 376 ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQT 555
+ G TTP F+ G ++L + LR LDLYAN+ + L N K + I+ E T
Sbjct: 63 AILFGATTTP-FNVPG-YRSLIVTLRKELDLYANLRIIPDLSNGK------EIVIVRENT 114
Query: 556 EGXYSALEHESVPGVXECLKIITASKSERIAKXAFD 663
EG Y A + +IIT + RIAK A +
Sbjct: 115 EGLY-ARDGIGFSDRAIDFRIITLEGARRIAKFAIN 149
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 52.8 bits (121), Expect = 8e-06
Identities = 47/163 (28%), Positives = 73/163 (44%), Gaps = 12/163 (7%)
Frame = +1
Query: 214 IPGDGVGP----ELVYAVQEVFKAASIPXD-----FESFFFSEVNPTLSAPLEDVVNSIA 366
+ GDG+GP E + +Q + + D E E + A +D ++++
Sbjct: 21 VDGDGIGPYITGEAIRVLQSLLRDELERGDVEFRKIEGLSIEERARAMKALPDDALDALK 80
Query: 367 VNKICIKGILTTPDFSHTG-ELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXII 543
+ +KG LTTP L++ N+ +R LDL+ANV V S+P+ +D
Sbjct: 81 KCHVILKGPLTTPKKGDPWPNLESANVAMRRELDLFANVRPV-SIPS-----EGIDWVFF 134
Query: 544 TEQTEGXY--SALEHESVPGVXECLKIITASKSERIAKXAFDY 666
E TEG Y + + K+IT SERI + AFDY
Sbjct: 135 RENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDY 177
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 52.4 bits (120), Expect = 1e-05
Identities = 50/184 (27%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAA------SIPXDFESFFFSEVNPTLSAPLEDVVNS 360
++ ++P DG+GPE+V A EV ++A + D++ F+ + + ++V+
Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAK 60
Query: 361 IAVNKICIKGILTTPDFSHTGE-LQTLNMXLRXALDLYANVVHVKSLPNVKCXHXD---V 528
I G + D+ + + ++ R LDLYANV ++ P + + +
Sbjct: 61 AKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTM 120
Query: 529 DCXIITEQTEGXY-------SALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRK 687
D I+ E TEG Y E P + L+ IT SERIA+ AF+ +K +K
Sbjct: 121 DLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR-KK 179
Query: 688 XVTA 699
VTA
Sbjct: 180 KVTA 183
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 52.4 bits (120), Expect = 1e-05
Identities = 52/172 (30%), Positives = 80/172 (46%), Gaps = 10/172 (5%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAP-------LEDVVNSIAV 369
+I GDG+G ++ A Q+V AA+ S + V SA ED V++I
Sbjct: 78 IIHGDGIGTDVGPAAQKVLDAAAEATG-RSIAWMRVYAGGSARDMYDENLPEDTVSAIRD 136
Query: 370 NKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANV---VHVKSLPNVKCXHXDVDCXI 540
+++ IKG LTTP ++LN+ LR LDLYANV ++ +P+ +D
Sbjct: 137 HRVAIKGPLTTP---VGAGFRSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKMDMIT 193
Query: 541 ITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
E TE Y+ +E E+ E ++ E IA D V +G K ++
Sbjct: 194 FRENTEDVYAGIEWEAGTDEVEQVRDFLEDDME-IADVIHDGPVGIGVKPIS 244
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 52.0 bits (119), Expect = 1e-05
Identities = 50/180 (27%), Positives = 80/180 (44%), Gaps = 19/180 (10%)
Frame = +1
Query: 214 IPGDGVGPELVYAVQEVFKA-----ASIPXDFESF-----FFSEVNPTLSAPLEDVVNSI 363
IPGDG+G E++ A +V +A S +FE+F ++ E + A D +++I
Sbjct: 9 IPGDGIGKEVIPAGAQVLEALARTSKSFAFEFENFGWGGDYYREHGVMMPA---DGLDAI 65
Query: 364 AVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNV-----KCXHXDV 528
+ G PD L L + + D YANV + LP + +C D+
Sbjct: 66 RNKDAILFGSAGDPDIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDGPLKRCKPGDL 125
Query: 529 DCXIITEQTEGXYSAL---EHESVP-GVXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
+ I+ E +EG YS + H+ P + I+T + ERI + AF RK +T
Sbjct: 126 NWVIVRENSEGEYSGVGGRVHQGHPIEAATDVSILTRAGVERIMRFAFRLAQSRPRKLLT 185
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 50.4 bits (115), Expect = 4e-05
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 9/160 (5%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAASIPXDFESF-----FFSEVNPTLSAPLEDVVNSIAVNK 375
+IPGDG+G E++ A V +A +P FE+ F L P + + A +
Sbjct: 10 VIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEAL--PSATLTAARAADA 67
Query: 376 ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHV-KSLP--NVKCXHXDVDCXIIT 546
I + G + +P + G + + LR LDLYAN+ V LP VD ++
Sbjct: 68 I-LFGAVASPGYPVAGYRSPI-VRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVR 125
Query: 547 EQTEGXYSALEHESVPGVXECL-KIITASKSERIAKXAFD 663
E TE Y+ E G ++IT S RI + A D
Sbjct: 126 ENTEDVYAGRERVEDDGATAIAERVITRRASARIMRVACD 165
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 49.2 bits (112), Expect = 1e-04
Identities = 30/83 (36%), Positives = 44/83 (53%)
Frame = +1
Query: 448 LRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXECLKIITA 627
+R LYAN+ VK+LP V ++DC + E E Y E++ V V LK+IT
Sbjct: 50 IRMRYTLYANIRPVKNLPGVPAVR-EIDCVFVRENVEDVYVGAEYK-VGDVAIALKVITE 107
Query: 628 SKSERIAKXAFDYTVKMGRKXVT 696
+ R+A+ A Y +M R+ VT
Sbjct: 108 KGTRRVARMARKY-AEMRRRRVT 129
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 49.2 bits (112), Expect = 1e-04
Identities = 45/156 (28%), Positives = 71/156 (45%), Gaps = 3/156 (1%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAASIPXDF---ESFFFSEVNPTLSAPLEDVVNSIAV 369
+K ++PGDG+G E+V EV K A +F E V +S D + ++
Sbjct: 1 MKIAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPAD-LETVKA 59
Query: 370 NKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITE 549
+ G +T+P +++ + LR LDLYAN+ +S P V+ I E
Sbjct: 60 CDCVLFGAITSPPGK---PYRSIILTLRKELDLYANIRPFRSCP---ISPRKVNFTIYRE 113
Query: 550 QTEGXYSALEHESVPGVXECLKIITASKSERIAKXA 657
+E Y +E E +++IT SERIA+ A
Sbjct: 114 NSEDLYMGIE-EITGDEARSVRVITRKASERIARAA 148
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 48.0 bits (109), Expect = 2e-04
Identities = 44/172 (25%), Positives = 72/172 (41%), Gaps = 6/172 (3%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAASIPXDFE-SFFFSEVNPTLSAPLEDVVNSIAVNK 375
+ +I GDG+GPE+V A +V + F F E + + + +
Sbjct: 2 VTVAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEFVFVEAGDRAKEKYGEALPKESYER 61
Query: 376 ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQT 555
+ + T + + LR LDL+AN+ K LP V +VD I+ E
Sbjct: 62 LLRADAILKGPVGETAA--DVIVRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRENI 119
Query: 556 EGXYSALEH---ESVPG--VXECLKIITASKSERIAKXAFDYTVKMGRKXVT 696
E Y E+ ++ G V L++ + ++ R+AK A +Y K R VT
Sbjct: 120 EDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEY-AKARRNKVT 170
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 47.6 bits (108), Expect = 3e-04
Identities = 49/181 (27%), Positives = 80/181 (44%), Gaps = 15/181 (8%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTL----SAPLEDVVNSIA 366
+K +I GDG+G E++ E K + +FE L +A ED +
Sbjct: 2 MKVCVIEGDGIGKEVI---PEAIKILNELGEFEIIKGEAGLECLKKYGNALPEDTIEKAK 58
Query: 367 VNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKS---------LPNVKCXH 519
I + G +T+P ++ + LR LYANV + + + + + +
Sbjct: 59 EADIILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLN 118
Query: 520 X-DVDCXIITEQTEGXYSALEH-ESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXV 693
++D II E TE Y E E+ + E ++IT SERI + AF+Y +K RK V
Sbjct: 119 AKNIDIVIIRENTEDLYVGRERLENDTAIAE--RVITRKGSERIIRFAFEYAIKNNRKKV 176
Query: 694 T 696
+
Sbjct: 177 S 177
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 39.9 bits (89), Expect(2) = 3e-04
Identities = 24/65 (36%), Positives = 34/65 (52%)
Frame = +1
Query: 169 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLED 348
+ P A G + T+ PGDG GPEL+ V +A +P DFE EV + +A ED
Sbjct: 6 IPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFE-----EVVVSSNADEED 60
Query: 349 VVNSI 363
+ S+
Sbjct: 61 IRTSL 65
Score = 27.1 bits (57), Expect(2) = 3e-04
Identities = 10/15 (66%), Positives = 13/15 (86%)
Frame = +1
Query: 448 LRXALDLYANVVHVK 492
+R +LDLYANV+H K
Sbjct: 61 IRTSLDLYANVIHCK 75
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 47.2 bits (107), Expect = 4e-04
Identities = 50/184 (27%), Positives = 74/184 (40%), Gaps = 19/184 (10%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEV----------FKAASIPXDFESFFFSEVNPTLSAPLEDV 351
K IP DG+GPE++ A +V FK + D+ S ++ + + A D
Sbjct: 5 KIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPA---DG 61
Query: 352 VNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNV-----KCX 516
++ + G + PD L L + + D YANV K LP + C
Sbjct: 62 LDKLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCG 121
Query: 517 HXDVDCXIITEQTEGXYS---ALEHESVP-GVXECLKIITASKSERIAKXAFDYTVKMGR 684
D+D I+ E +EG YS H +P V + I T RI + AF R
Sbjct: 122 PGDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPR 181
Query: 685 KXVT 696
K +T
Sbjct: 182 KLLT 185
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 46.8 bits (106), Expect = 5e-04
Identities = 38/169 (22%), Positives = 67/169 (39%), Gaps = 8/169 (4%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTL---SAPLEDVVNSIAVNKIC 381
+IPGDG+GPE++ +V A + + + L A ++ I ++
Sbjct: 24 VIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALTGSDLDRIRSSEAA 83
Query: 382 IKGILTTPDFSHTGELQTLNMXLRXALDLYAN-----VVHVKSLPNVKCXHXDVDCXIIT 546
+ G + P T ++ + LR LDLY N + H + P +DC I+
Sbjct: 84 LLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARRAIDCVIVR 143
Query: 547 EQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKXV 693
E TEG YS + + G E + + + ++ R+ V
Sbjct: 144 ENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAARRSV 192
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 46.4 bits (105), Expect = 7e-04
Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 4/134 (2%)
Frame = +1
Query: 307 FSEVNPTLSAPLEDVVNSIAVNKICIKGILTTPDFSHTGE-LQTLNMXLRXALDLYANVV 483
+ E++P L D + +I K+ IKG LTTP GE ++LN+ LR +DLY +
Sbjct: 84 YKELSPEEQWLLPDTIEAINHYKVSIKGPLTTP----IGEGFRSLNVALRQKMDLYVCLR 139
Query: 484 HVK--SLPNVKCXHXDVDCXIITEQTEGXYSALEHESVPGVXECLKIITASKSE-RIAKX 654
V+ P+ VD I E +E Y+ +E + G E K+I ++E ++ K
Sbjct: 140 PVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQE--GSAEAKKLIHFLQNELKVKKI 197
Query: 655 AFDYTVKMGRKXVT 696
F + +G K ++
Sbjct: 198 RFPESSGIGVKPIS 211
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 46.0 bits (104), Expect = 9e-04
Identities = 49/171 (28%), Positives = 73/171 (42%), Gaps = 16/171 (9%)
Frame = +1
Query: 220 GDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSA------PLED-VVNSIAVNKI 378
GDG+G E+V A Q V AA + + + E+ L A P+ D ++++
Sbjct: 18 GDGIGHEIVPATQRVVSAAVVAAGGGAVDWVELPLGLGAIESHGTPIPDSTLSALDALDA 77
Query: 379 CIKGILTTPDFSHT--GELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITEQ 552
I G + + G L T +R DL+AN+ +SL V D+D I+ E
Sbjct: 78 WILGPHDSAAYPEPFRGRL-TPGGVVRKRFDLFANIRPARSLEGVASTVPDMDLVIVREN 136
Query: 553 TEGXYS-------ALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGR 684
TEG Y+ + E P V + ++T ERIA AF GR
Sbjct: 137 TEGLYADRNMFAGSGEFMPTPDVALAVGVVTRKACERIAHTAFALARTRGR 187
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 46.0 bits (104), Expect = 9e-04
Identities = 49/180 (27%), Positives = 75/180 (41%), Gaps = 18/180 (10%)
Frame = +1
Query: 214 IPGDGVGPELVYAVQEVFKAASIPX----DFESFFFSEVNPTLSAPL---EDVVNSIAVN 372
IPGDG+G E++ V +AA++ +F++F ++ + L +D +
Sbjct: 11 IPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDDWAEQLKQY 70
Query: 373 KICIKGILTTPDF--SHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHX-----DVD 531
G + PD H +L + R D Y N+ V+ P V C D+D
Sbjct: 71 DAIYFGAVDWPDKVPDHISLWGSL-LKFRREFDQYVNIRPVRLFPGVPCALANRKVGDID 129
Query: 532 CXIITEQTEGXYSALEHESVPGVXECL----KIITASKSERIAKXAFDYTVKMGRKXVTA 699
++ E TEG YS+L + I T +RI K AFD K RK VT+
Sbjct: 130 FVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRERKHVTS 189
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 45.6 bits (103), Expect = 0.001
Identities = 46/177 (25%), Positives = 72/177 (40%), Gaps = 15/177 (8%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDF--ESFFFSEVNPTLSAPLE----DVVNSI 363
K ++PGDG GPE++ +V AA F E +++ A E D +
Sbjct: 6 KIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTTEKEYYNWGGAHYLATGETLPADAKEQL 65
Query: 364 AVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKC-----XHXDV 528
A + + G + PD + + + LR LD Y N+ VK P V+ D+
Sbjct: 66 ARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKKPEDI 125
Query: 529 DCXIITEQTEGXYSALEHE---SVPGVXECLK-IITASKSERIAKXAFDYTVKMGRK 687
D ++ E + G Y+ + P C I T S+ +R K AF+ K K
Sbjct: 126 DYVVVRENSGGVYTGMGGNVQIDTPEEVACQNWIYTRSQVDRCLKFAFELAEKRHTK 182
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 45.2 bits (102), Expect = 0.002
Identities = 53/184 (28%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELV----YAVQEVFKAASIPXDFESFFFS-----EVNPTL-SAPLED 348
IK +IPGDG+G E+V ++++ + +++ DF+ + F + TL LE+
Sbjct: 2 IKIAVIPGDGIGKEVVAEGLKVLRKIEELSNVKFDFQEYPFGAEHYLKTGETLPDWALEE 61
Query: 349 VVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVK----SLPNVKCX 516
+ A+ I P G L + LR +LDLY N+ VK L +K
Sbjct: 62 FRHFDAIYFGAIGDPRVKPGILEHGIL----LKLRFSLDLYVNLRPVKLYHPKLTPLK-G 116
Query: 517 HXDVDCXIITEQTEGXYS---ALEHESVPGVXECLKII-TASKSERIAKXAFDYTVKMGR 684
+D I E TEG Y+ + P ++I T ER + AF+Y GR
Sbjct: 117 KEKIDMVFIRENTEGLYAGAGGFLRKGTPHEVAIQEMINTRFGVERTIRFAFEYAKTKGR 176
Query: 685 KXVT 696
K VT
Sbjct: 177 KKVT 180
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 44.4 bits (100), Expect = 0.003
Identities = 45/182 (24%), Positives = 76/182 (41%), Gaps = 15/182 (8%)
Frame = +1
Query: 196 RIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAVNK 375
R+K ++ GD +G E+V A EV +AA+ +++V P +A LE +++
Sbjct: 5 RLKLGILNGDDIGHEIVPASVEVARAAAGKAGL-GIDWTDV-PIGAAALESHGHTMPEGT 62
Query: 376 I--------CIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVD 531
+ I G + D+ + LR DL+ANV +S P + C D+D
Sbjct: 63 METLEGLDGWILGPIGHRDYPKVPGAINPHPILRKGFDLFANVRPTRSYPGIGCLFDDID 122
Query: 532 CXIITEQTEGXY-------SALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRKX 690
I+ E EG + E V +++IT ++ + A D RK
Sbjct: 123 LVIVRENNEGFQPDRNVVAGSGEFRPTEDVTISVRVITVEGCRKVVRAALDIARSRPRKK 182
Query: 691 VT 696
+T
Sbjct: 183 LT 184
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 44.0 bits (99), Expect = 0.004
Identities = 40/170 (23%), Positives = 73/170 (42%), Gaps = 8/170 (4%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIP--XDFESFFFSEVNPTLSAPLEDVVNSIAVNK 375
K +IPGDG+G E++ +++F++ ++P D+ + T D ++ +
Sbjct: 12 KIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQYD 71
Query: 376 ICIKGIL----TTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNV--KCXHXDVDCX 537
+ G L T PD+ L+ L + +R LD + + K P + ++D
Sbjct: 72 AILLGSLGDPRTLPDYV---TLEPL-IQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVL 127
Query: 538 IITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGRK 687
++ E +EG YS + G E I +A S R + Y + RK
Sbjct: 128 VVRENSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFEASRK 177
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 42.3 bits (95), Expect = 0.011
Identities = 35/130 (26%), Positives = 63/130 (48%), Gaps = 10/130 (7%)
Frame = +1
Query: 220 GDGVGPELVYAVQEVFKAASIPXD----FESFFFSEVNPTLSAPL--EDVVNSIAVNKIC 381
GDG+GPE++ A ++V AA+ ++ + L E+ + +I ++
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEILLGDRAEELKGDRFPEESIKAINDYRVL 83
Query: 382 IKGILTTPDFSHTGE-LQTLNMXLRXALDLYANVVHVKSLPNVKCXHXD---VDCXIITE 549
+K L TP G+ +++N+ +R LDLYAN+ VK +P ++ + V+ I E
Sbjct: 84 LKAPLNTP----VGKGFKSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRE 139
Query: 550 QTEGXYSALE 579
T+ Y E
Sbjct: 140 NTDDLYLGYE 149
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 41.9 bits (94), Expect = 0.015
Identities = 46/181 (25%), Positives = 78/181 (43%), Gaps = 14/181 (7%)
Frame = +1
Query: 196 RIKCTLIPGDGVGPELVYAVQEVFKA----ASIPXDFESF-FFSEVNPTLSAPLED-VVN 357
+++ +IPGDG+G E+V +V K + + +F+ + F +E L D +
Sbjct: 2 KLRIAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIE 61
Query: 358 SIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVK----SLPNVKCXHXD 525
G + P + + + +R LDLY N+ VK L +K +
Sbjct: 62 EFKKFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNK- 120
Query: 526 VDCXIITEQTEGXYSALE---HESVPGVXECLKII-TASKSERIAKXAFDYTVKMGRKXV 693
+D + E TEG Y+ + P ++I T ER+ + AF+Y + GRK V
Sbjct: 121 IDIVFVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKV 180
Query: 694 T 696
T
Sbjct: 181 T 181
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 41.5 bits (93), Expect = 0.019
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 12/167 (7%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAAS----IPXDFESFF--FSEVNPTLSAPLEDVVNSIAVN 372
LIPGDG+G E++ A ++V + + + +F + F T A ++ V +
Sbjct: 28 LIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQ 87
Query: 373 -KICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXHXDVDCXIITE 549
+ + G + +P G + + LR + L+ANV VKS+ K +D I+ E
Sbjct: 88 CQGALFGAVQSPTTKVEGYSSPI-VALRREMGLFANVRPVKSVEGEK--GKPIDMVIVRE 144
Query: 550 QTEGXYSALEH---ESVPG--VXECLKIITASKSERIAKXAFDYTVK 675
TE Y +E + G V + K I+ + RIA A D +K
Sbjct: 145 NTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALK 191
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 39.5 bits (88), Expect = 0.078
Identities = 24/85 (28%), Positives = 46/85 (54%), Gaps = 3/85 (3%)
Frame = +1
Query: 343 EDVVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVK---SLPNVKC 513
++ + ++ KI IKG LTTP G ++LN+ LR +DL+ N+ +K +LP+
Sbjct: 87 QETIQAVRACKIAIKGPLTTP---LGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLK 143
Query: 514 XHXDVDCXIITEQTEGXYSALEHES 588
+ ++ + +E YS +E ++
Sbjct: 144 NPFLTNITVLRDSSEDVYSGIEWQA 168
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 39.5 bits (88), Expect = 0.078
Identities = 27/82 (32%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Frame = +1
Query: 343 EDVVNSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKCXH- 519
ED + +I + IKG LTTP G +++LN+ LR DLY V + P H
Sbjct: 86 EDTLTAIKEYGVAIKGPLTTP---VGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK 142
Query: 520 --XDVDCXIITEQTEGXYSALE 579
+D + E TE Y +E
Sbjct: 143 TPEKLDIIVYRENTEDIYLGIE 164
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 39.5 bits (88), Expect = 0.078
Identities = 16/26 (61%), Positives = 20/26 (76%)
Frame = +1
Query: 208 TLIPGDGVGPELVYAVQEVFKAASIP 285
TLIPGDG+GPE+ AV ++F AA P
Sbjct: 8 TLIPGDGIGPEISAAVMKIFDAAKAP 33
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 39.1 bits (87), Expect = 0.10
Identities = 17/32 (53%), Positives = 22/32 (68%)
Frame = +1
Query: 175 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFK 270
P A GR T+IPGDG+GPEL+ V+ VF+
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFR 136
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 38.3 bits (85), Expect = 0.18
Identities = 40/163 (24%), Positives = 62/163 (38%)
Frame = -2
Query: 696 GDXLAAHLHGVVESXFRDTLGFRCGDDLQALXHAGNGFMFQS*VLSLGLLCDDXXXXXXX 517
GD L L G V+ D+LGF G DL L H +FQS + + + D+
Sbjct: 49 GDQLTVVLLGKVKCKLGDSLGFEPGHDLHRLNHTRVRLVFQSRIFTFSVFSDEGKVNALQ 108
Query: 516 XXXXXXXXXXXXXXXVKIQGXAEXHV*GL*LASVREVRSG*DTLDTNLVNSDRVYDVFEW 337
IQ ++ ++ + R S DT ++LV+ R + +
Sbjct: 109 TRLDAGNVFDQDQRSKNIQFFSQRNIQRF---AGRSSWSKQDTFQSHLVSLQRFHSLGNP 165
Query: 336 CTKCWIHFRKEKGFKVXWNAGRLENFLYSVDKLGSYTIPRNQG 208
T + R F + RLEN L + + TI N+G
Sbjct: 166 GT--LVQTRNINSFPFDGDVFRLENGLDGIGDFLTNTISWNEG 206
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 37.1 bits (82), Expect = 0.41
Identities = 47/180 (26%), Positives = 74/180 (41%), Gaps = 17/180 (9%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELVYAVQEVFKAAS-----IPXDFESFFFS---EVNPTLSAPLEDVV 354
+ +IPGDG+G E V A + V AA+ I ++ F + + AP + +
Sbjct: 4 VSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAP-KGFL 62
Query: 355 NSIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKC-----XH 519
N++A + G + P L L + +R + Y N+ V+ L V
Sbjct: 63 NTLANFDTILLGAVGYPGVPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRNP 122
Query: 520 XDVDCXIITEQTEGXYSALE---HESVP-GVXECLKIITASKSERIAKXAFDYTVKMGRK 687
DV+ I E TEG YS + H +P V + T +ERI + A+ RK
Sbjct: 123 GDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAPRK 182
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 36.3 bits (80), Expect = 0.72
Identities = 41/178 (23%), Positives = 70/178 (39%), Gaps = 16/178 (8%)
Frame = +1
Query: 211 LIPGDGVGPE-------LVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLEDVVNSIAV 369
++ GDG+GPE L+ +Q D S E + A + ++
Sbjct: 9 ILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQSAYDACLA 68
Query: 370 NKICIKGILTTPDFSH-TGELQTLNMXLRXALDLYANV-----VHVKSLPNVKCXHXDVD 531
+ + G + P+ + G+ + LR L LY V H P ++D
Sbjct: 69 SDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGEID 128
Query: 532 CXIITEQTEGXYSALEHESVPGVXECLKI--ITASKSERIAKXAFDYTVKM-GRKXVT 696
++ E TEG + + + E + IT S SER+ + AF+ + G+K VT
Sbjct: 129 FVLVRESTEGLFYGRDAIADLEADEATNLLRITRSASERVCRLAFETARRRDGKKTVT 186
>UniRef50_Q973N4 Cluster: Putative uncharacterized protein ST0866;
n=1; Sulfolobus tokodaii|Rep: Putative uncharacterized
protein ST0866 - Sulfolobus tokodaii
Length = 344
Score = 35.5 bits (78), Expect = 1.3
Identities = 27/111 (24%), Positives = 54/111 (48%), Gaps = 1/111 (0%)
Frame = +1
Query: 169 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSEVNPTLSAPLED 348
L+ A K G++K I G+ P + ++E+ ASI ++ +FF ++NP +
Sbjct: 19 LKEIAEKAGKMKFNEI-WSGIDPNYIDGIKEI---ASIAEKYDMYFFVDINPEIMRGFGA 74
Query: 349 VVNSIAVNK-ICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSL 498
+++ V K + IKG+ F+ ++ N L ++L A++ + L
Sbjct: 75 SPSNLKVFKELKIKGLRADYGFTIDDLIKMANNNLDLVIELNASIFPLDKL 125
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 35.1 bits (77), Expect = 1.7
Identities = 43/166 (25%), Positives = 72/166 (43%), Gaps = 15/166 (9%)
Frame = +1
Query: 211 LIPGDGVGPELVYAVQEVFKAA---------SIPXDFESFFFS-EVNPTLSAPLEDVVNS 360
++ GDG+GPE+ A V +A P + F + + P S ++
Sbjct: 9 VVHGDGIGPEVARAAVAVLQAGVQAGTLRFVDYPAGADHFLKTGDSFPAASFEGCRTADA 68
Query: 361 IAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHV---KSLPNVKCXHXDVD 531
I I G++ PD + G TL LR LDL+ANV + K +P+ +D
Sbjct: 69 ILHGAAGIPGVVH-PDGTEAGLDFTLT--LRFKLDLFANVRPIKLYKGVPSPLGRPGPID 125
Query: 532 CXIITEQTEGXYSALEHESVPGVXECLKIITASKS--ERIAKXAFD 663
I+ E +EG Y+A ++ + + ++ ERI + AF+
Sbjct: 126 YVIVRENSEGLYAARGAGALLREEVAVDTLVQTRKGVERIVRFAFE 171
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 35.1 bits (77), Expect = 1.7
Identities = 44/183 (24%), Positives = 70/183 (38%), Gaps = 16/183 (8%)
Frame = +1
Query: 199 IKCTLIPGDGVGPELV---YAVQEVFKAASIPXDFESFFF---SEVNPTLSAPL-EDVVN 357
+K +I GDG+GPE++ V + S FE +F E + +D +
Sbjct: 4 LKVAVIAGDGIGPEVMDEGVKVLQTIANVSQQFKFEFTYFPWGCEFYSKHGKMMDDDGIE 63
Query: 358 SIAVNKICIKGILTTPDFSHTGELQTLNMXLRXALDLYANVVHVKSLPNVKC-----XHX 522
+ G + P L L + +R + D Y N+ V L C
Sbjct: 64 QLKAFDAIYLGAVGFPGVPDYISLWDLLLRIRQSFDQYVNIRPVTLLKGAPCPLKDVKRE 123
Query: 523 DVDCXIITEQTEGXYSALEHESVPG----VXECLKIITASKSERIAKXAFDYTVKMGRKX 690
D+D I E +EG Y+ G V + + +ERI + AF+ K RK
Sbjct: 124 DIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIARK-ERKS 182
Query: 691 VTA 699
+T+
Sbjct: 183 LTS 185
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 35.1 bits (77), Expect = 1.7
Identities = 16/38 (42%), Positives = 24/38 (63%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDFESFFFSE 315
+ T++PGDG+GPE+ V +AA + ESF F+E
Sbjct: 40 RVTVLPGDGIGPEITAVTLSVLEAAG-KAEGESFTFTE 76
>UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit beta,
mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase)
(NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 103
Score = 34.3 bits (75), Expect = 2.9
Identities = 14/22 (63%), Positives = 17/22 (77%)
Frame = +1
Query: 190 EGRIKCTLIPGDGVGPELVYAV 255
EG T++PGDGVGPEL+ AV
Sbjct: 12 EGAFPVTMLPGDGVGPELMAAV 33
>UniRef50_Q0M010 Cluster: FAD dependent oxidoreductase; n=9;
Proteobacteria|Rep: FAD dependent oxidoreductase -
Caulobacter sp. K31
Length = 371
Score = 33.9 bits (74), Expect = 3.9
Identities = 16/46 (34%), Positives = 25/46 (54%)
Frame = +1
Query: 61 RNIFRAVMQGSQHVGKGVHTSSVTTEKNVCYAPFGALQPRATKEGR 198
R + AV++G H+G+GV + + Y P G+L+ R EGR
Sbjct: 28 RGLVVAVLEGEGHIGQGVSSRNSEVIHGGLYYPTGSLKARLCVEGR 73
>UniRef50_A5E2P5 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 964
Score = 33.5 bits (73), Expect = 5.1
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Frame = +2
Query: 32 YQIQTCPFLXGIFFELLCRDLNMLERVYTQ---VR*QRRKMYVMHHLEPCNRGQQR 190
Y I TC F IF + + + + YT+ + + +YV+HH CN+G +R
Sbjct: 802 YVIITCSFYSCIFIGITILNGGLEDEGYTESDLLTLLKNSVYVLHHYSTCNKGAER 857
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 33.1 bits (72), Expect = 6.7
Identities = 46/181 (25%), Positives = 76/181 (41%), Gaps = 15/181 (8%)
Frame = +1
Query: 202 KCTLIPGDGVGPELVYAVQEVFKAASIPXDF----ESFFFSEVNPTLSA-PL-EDVVNSI 363
K + GDG+GPE++ A EVF A + +F E+ F S PL +D + +
Sbjct: 3 KIVTLAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHPLPDDTLAAA 62
Query: 364 AVNKICIKGILTTPDFSHTGELQTLN-MXLRXALDLYANVVHV------KSLPNVKCXH- 519
+ + +P + + +R L+L+AN+ V + L +K
Sbjct: 63 KTADAILLAAIGSPQYDKAPVRPEQGLLAIRKELNLFANIRPVRIFDALRHLSPLKAERI 122
Query: 520 XDVDCXIITEQTEGXYSALEHESVPGVXECLKIITASKSERIAKXAFDYTVKMGR-KXVT 696
VD ++ E T G Y +H + +AS+ RI + AF + GR K VT
Sbjct: 123 AGVDFVVVRELTGGIYFG-QHTLTENSACDINEYSASEIRRIMRKAF--AIARGRSKKVT 179
Query: 697 A 699
+
Sbjct: 180 S 180
>UniRef50_UPI0000E4A693 Cluster: PREDICTED: similar to
ENSANGP00000018738; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000018738
- Strongylocentrotus purpuratus
Length = 514
Score = 32.7 bits (71), Expect = 8.9
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Frame = -2
Query: 261 FLYSVDKLGSYTIPRN-QGAFDTTFLCCPRLQGSKW 157
+ Y D L Y + ++ QG +DT CP L GSKW
Sbjct: 456 YSYKNDSLFWYNLRKSGQGNYDTRHAACPVLSGSKW 491
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 32.7 bits (71), Expect = 8.9
Identities = 24/92 (26%), Positives = 36/92 (39%), Gaps = 9/92 (9%)
Frame = +1
Query: 451 RXALDLYANVVHVKSLPNVKCX-----HXDVDCXIITEQTEGXYSALEHESVPGVXECL- 612
R D Y N+ + V C D+D I+ E TEG YSA+ G
Sbjct: 98 RREFDQYVNLRPARLFDGVPCPLAGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFV 157
Query: 613 ---KIITASKSERIAKXAFDYTVKMGRKXVTA 699
+ T +ER+ K AF+ + ++ A
Sbjct: 158 VQQAVFTRHGTERVLKFAFELAQRRAKRLTVA 189
>UniRef50_Q5D2M8 Cluster: Eisenstasin II; n=1; Eisenia andrei|Rep:
Eisenstasin II - Eisenia andrei
Length = 187
Score = 32.7 bits (71), Expect = 8.9
Identities = 10/19 (52%), Positives = 12/19 (63%)
Frame = +3
Query: 99 CWKGCTHKFGNNGEKCMLC 155
CWK CTH F N+ C +C
Sbjct: 52 CWKECTHGFMNDSRGCQIC 70
>UniRef50_Q6ZV79 Cluster: CDNA FLJ42904 fis, clone BRHIP3013897;
n=1; Homo sapiens|Rep: CDNA FLJ42904 fis, clone
BRHIP3013897 - Homo sapiens (Human)
Length = 167
Score = 32.7 bits (71), Expect = 8.9
Identities = 20/50 (40%), Positives = 22/50 (44%), Gaps = 5/50 (10%)
Frame = -1
Query: 229 HHPQESRCI*YDLPLLPSVAGLQMVHNIHFSPLL---PNLCVH--PFQHV 95
HHP C Y PLLP VH++ P PN C H PF HV
Sbjct: 52 HHPYT--CCLYQHPLLPPPPPATTVHSLPHRPAFPHPPNTCTHSIPFPHV 99
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 644,246,527
Number of Sequences: 1657284
Number of extensions: 12923182
Number of successful extensions: 30199
Number of sequences better than 10.0: 84
Number of HSP's better than 10.0 without gapping: 29189
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 30129
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 55371905986
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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