Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-0304
(750 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 393 e-108
UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein; ... 376 e-103
UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular organ... 373 e-102
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 338 1e-91
UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5; ... 316 4e-85
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 287 3e-76
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 283 4e-75
UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate... 214 2e-54
UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2; ... 151 9e-48
UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase... 130 5e-29
UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase... 124 3e-27
UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4; Eukaryot... 116 6e-25
UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma j... 113 6e-24
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 105 9e-22
UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1; ... 94 3e-18
UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3... 90 6e-17
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 51 3e-05
UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza sa... 43 0.009
UniRef50_Q757T0 Cluster: Probable E3 ubiquitin-protein ligase HU... 37 0.61
UniRef50_A0C1D3 Cluster: Chromosome undetermined scaffold_141, w... 35 1.9
UniRef50_Q91L92 Cluster: ORF160; n=1; Shrimp white spot syndrome... 34 4.3
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 34 4.3
UniRef50_A0KSD7 Cluster: Putative uncharacterized protein; n=2; ... 34 4.3
UniRef50_Q61R47 Cluster: Putative uncharacterized protein CBG067... 33 7.5
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 393 bits (967), Expect = e-108
Identities = 178/247 (72%), Positives = 205/247 (82%), Gaps = 1/247 (0%)
Frame = +2
Query: 11 MDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNVGIK 190
MDGDEMTRI+W IKE+LI P+V + YFDLGLP+RD TDDQVTIDSA A K++V +K
Sbjct: 53 MDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVK 112
Query: 191 CATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPIVIGR 370
CATITPDE RVEEFKLKKMW SPNGTIRNILGGTVFREPI+C++IPR+VPGWTKPI IGR
Sbjct: 113 CATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGR 172
Query: 371 HAHGDQYKAQDFVVPKPGKVELVYTTRDGT-TERRVLYDFKTPGVAMGMYNTDESIRSFA 547
HAHGDQYKA DFV + G ++V+T +DG+ + +Y+F GV MGMYNTDESI FA
Sbjct: 173 HAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFA 232
Query: 548 HSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKIWYEHRLIDD 727
HS FQ A+QKKWPLY+STKNTILK YDGRFKDIF+E+F YKT FD+ KIWYEHRLIDD
Sbjct: 233 HSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDD 292
Query: 728 MVAQAIK 748
MVAQ +K
Sbjct: 293 MVAQVLK 299
>UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein;
n=6; core eudicotyledons|Rep: Isocitrate
dehydrogenase-like protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 485
Score = 376 bits (926), Expect = e-103
Identities = 169/247 (68%), Positives = 205/247 (82%), Gaps = 1/247 (0%)
Frame = +2
Query: 11 MDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNVGIK 190
MDGDEMTR++W+ IKE+LI PY+ +D YFDLG+ +RDATDD+VT++SA A LK+NV IK
Sbjct: 85 MDGDEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAEAALKYNVAIK 144
Query: 191 CATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPIVIGR 370
CATITPDE RV+EF LK MW SPNGTIRNIL GTVFREPI+C +IPR+VPGW KPI IGR
Sbjct: 145 CATITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVPGWEKPICIGR 204
Query: 371 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERRV-LYDFKTPGVAMGMYNTDESIRSFA 547
HA GDQY+A D V+ PGK+++V+ DG + +YDFK PGVA+ MYN DESIR+FA
Sbjct: 205 HAFGDQYRATDTVIKGPGKLKMVFVPEDGNAPVELDVYDFKGPGVALAMYNVDESIRAFA 264
Query: 548 HSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKIWYEHRLIDD 727
SS +AL KKWPLYLSTKNTILK+YDGRFKDIF+EV+++++K KF+E IWYEHRLIDD
Sbjct: 265 ESSMAMALTKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKQKFEEHSIWYEHRLIDD 324
Query: 728 MVAQAIK 748
MVA A+K
Sbjct: 325 MVAYAVK 331
>UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular
organisms|Rep: F12P19.10 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 410
Score = 373 bits (917), Expect = e-102
Identities = 167/246 (67%), Positives = 202/246 (82%)
Frame = +2
Query: 11 MDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNVGIK 190
MDGDEMTR++W IK++LI P+V++D YFDLGLPHRDATDD+VTI+SA A K+NV IK
Sbjct: 15 MDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAEATKKYNVAIK 74
Query: 191 CATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPIVIGR 370
CATITPDE RV EF LK+MW SPNGTIRNIL GTVFREPI+C+++P++VPGWTKPI IGR
Sbjct: 75 CATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVPGWTKPICIGR 134
Query: 371 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERRVLYDFKTPGVAMGMYNTDESIRSFAH 550
HA GDQY+A D V+ PGK+ + + +DG TE V GVAM MYNTDESIR+FA
Sbjct: 135 HAFGDQYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMYNTDESIRAFAD 194
Query: 551 SSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKIWYEHRLIDDM 730
+S A +KKWPLYLSTKNTILK+YDGRFKDIF+EV+++ +K+K+D A IWYEHRLIDDM
Sbjct: 195 ASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYDAAGIWYEHRLIDDM 254
Query: 731 VAQAIK 748
VA A+K
Sbjct: 255 VAYALK 260
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 338 bits (830), Expect = 1e-91
Identities = 154/215 (71%), Positives = 184/215 (85%), Gaps = 1/215 (0%)
Frame = +2
Query: 107 GLPHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILG 286
G+ +RD TDD+VT+++A AI K+ VG+KCATITPDE RVEEFKLKKMWLSPNGTIRNILG
Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160
Query: 287 GTVFREPILCQSIPRVVPGWTKPIVIGRHAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE 466
GTVFREPI+ +IPR+VPGWTKPI+IGRHA GDQY+A D V+P PGK+ELVYT +G E
Sbjct: 161 GTVFREPIVIPAIPRLVPGWTKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGQPE 220
Query: 467 RRVLYDFKT-PGVAMGMYNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKD 643
+YDF++ GVAM MYNTD+SIR FAHSSF++AL K PLY+STKNTILKRYDGRFKD
Sbjct: 221 SVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNTILKRYDGRFKD 280
Query: 644 IFEEVFQSDYKTKFDEAKIWYEHRLIDDMVAQAIK 748
IF+E+++++YK +FD IWYEHRLIDDMVAQ IK
Sbjct: 281 IFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIK 315
>UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5;
Eukaryota|Rep: Putative uncharacterized protein - Oryza
sativa subsp. indica (Rice)
Length = 475
Score = 316 bits (776), Expect = 4e-85
Identities = 160/280 (57%), Positives = 197/280 (70%), Gaps = 36/280 (12%)
Frame = +2
Query: 17 GDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNVGIKCA 196
GDEMTR++W IK++LIFP++ +D Y+DLGLP+RDAT D+VTI+SA A LK+NV IKCA
Sbjct: 42 GDEMTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIESAEATLKYNVAIKCA 101
Query: 197 TITP------------------DEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQS 322
TITP DE RV+EF L MW SPNGTIRNIL GTVFREPI+C++
Sbjct: 102 TITPVLDTQFKFDFGRTIHEPTDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREPIICKN 161
Query: 323 IPRVVPGWTKPIVIGRHAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERRVLYDFKTPGV 502
IPR+VPGW KPI IGRHA GDQY+A D V+ PGK++LV+ R+ E V GV
Sbjct: 162 IPRLVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKLVFDGREEQIELDVFNFTGAGGV 221
Query: 503 AMGMYNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTK 682
A+ MYNTDESI +FA +S +A QK+WPLYLSTKNTILK+YDGRFKDIF+E +++ ++ K
Sbjct: 222 ALSMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFKDIFQENYETKWRAK 281
Query: 683 FDEAKIW------------------YEHRLIDDMVAQAIK 748
FD+A IW YEHRLIDDMVA A+K
Sbjct: 282 FDDAGIWNMEPYFPPLCPNHFCCGRYEHRLIDDMVAYALK 321
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 287 bits (703), Expect = 3e-76
Identities = 131/249 (52%), Positives = 178/249 (71%)
Frame = +2
Query: 2 LSXMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNV 181
L MDGDEMTRI+W IK+ L+ P++ ++ Y+DLGL +R+ TDDQVTID+A A K+ V
Sbjct: 25 LVEMDGDEMTRILWKMIKDELLLPFIDLNTEYYDLGLNYRNETDDQVTIDAAEATKKYGV 84
Query: 182 GIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPIV 361
+KCATITP+ R++E+ LKKM+ SPNGTIR IL GTVFR PI+ + I V W KPI
Sbjct: 85 AVKCATITPNHARMDEYDLKKMYKSPNGTIRAILDGTVFRAPIVVKGIEPCVRNWKKPIT 144
Query: 362 IGRHAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERRVLYDFKTPGVAMGMYNTDESIRS 541
+ RHA+GD YK + + KPGKVELVYT+ DG +R ++ +FK PGVAMGM+N SI S
Sbjct: 145 LARHAYGDIYKNTEMYIDKPGKVELVYTSEDGEEKRSLVQEFKAPGVAMGMHNMTASIES 204
Query: 542 FAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKIWYEHRLI 721
FA S F AL K ++ K+TI K YD +FK++F+ VF +++K +F+EA + Y + LI
Sbjct: 205 FARSCFNYALDTKQDVWFGAKDTISKTYDAKFKEVFQTVFDTEFKDRFEEAGLTYFYSLI 264
Query: 722 DDMVAQAIK 748
DD+VA+ +K
Sbjct: 265 DDIVARVMK 273
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 283 bits (693), Expect = 4e-75
Identities = 131/249 (52%), Positives = 179/249 (71%)
Frame = +2
Query: 2 LSXMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNV 181
L MDGDEMTRI+W IKE L+ PY+ + Y+DLGL R+ T+D++TI++A+AI K+ V
Sbjct: 11 LVEMDGDEMTRIIWKMIKELLLEPYIDLKTEYYDLGLVKRNETNDEITIEAANAIKKYGV 70
Query: 182 GIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPIV 361
G+KCATITP+ +RV+E+ LK MW SPNGTIR IL GTVFR PI+ SI ++ W KPI
Sbjct: 71 GVKCATITPNAKRVKEYNLKSMWKSPNGTIRAILDGTVFRTPIIVNSIRPLMRTWEKPIT 130
Query: 362 IGRHAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERRVLYDFKTPGVAMGMYNTDESIRS 541
+ RHA+GD Y+ ++ V +PGK+ELV+T+ G R+ L+ F PGV MGM+N D+SI S
Sbjct: 131 VARHAYGDVYRDVEYKVEEPGKMELVFTSEKGEETRQTLHVFNGPGVVMGMHNLDKSIES 190
Query: 542 FAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKIWYEHRLI 721
FA S F AL L+ ++K+TI K YD RFKDIF+E++ ++Y KF++A I Y + LI
Sbjct: 191 FARSCFNYALDMNQNLWFASKDTISKTYDHRFKDIFQEIYDTEYDAKFNDAGIEYFYTLI 250
Query: 722 DDMVAQAIK 748
DD VA+ +K
Sbjct: 251 DDAVARVVK 259
>UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 1 (NADP+), soluble; n=2; Danio rerio|Rep:
PREDICTED: similar to Isocitrate dehydrogenase 1
(NADP+), soluble - Danio rerio
Length = 206
Score = 214 bits (522), Expect = 2e-54
Identities = 91/126 (72%), Positives = 114/126 (90%)
Frame = +2
Query: 11 MDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNVGIK 190
M GDEMTR++W IKE+LIFPY+++D +DLG+ +RDATDD+VT+++A A+ ++NVGIK
Sbjct: 20 MQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIK 79
Query: 191 CATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPIVIGR 370
CATITPDE+RVEEFKLK+MW SPNGTIRNILGGTVFRE I+C++IPR+VPGW KPI+IGR
Sbjct: 80 CATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPIIIGR 139
Query: 371 HAHGDQ 388
HAHGDQ
Sbjct: 140 HAHGDQ 145
>UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 371
Score = 151 bits (365), Expect(2) = 9e-48
Identities = 66/91 (72%), Positives = 78/91 (85%)
Frame = +2
Query: 476 LYDFKTPGVAMGMYNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEE 655
+Y+FK PGVA+ MYN DESIR+FA SS +AL KKWPLYLSTKNTILK+YDGRFKDIF+E
Sbjct: 44 VYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFKDIFQE 103
Query: 656 VFQSDYKTKFDEAKIWYEHRLIDDMVAQAIK 748
V++ +K KF+E IWYEHRLIDDMVA A+K
Sbjct: 104 VYEEKWKEKFEENSIWYEHRLIDDMVAYAVK 134
Score = 91.5 bits (217), Expect = 2e-17
Identities = 40/58 (68%), Positives = 49/58 (84%)
Frame = +2
Query: 527 ESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKI 700
+SIR+FA SS +AL KKWPLYLSTKNTILK+YDGRFKDIF+EV++ +K KF+E I
Sbjct: 157 QSIRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSI 214
Score = 62.9 bits (146), Expect(2) = 9e-48
Identities = 27/40 (67%), Positives = 33/40 (82%), Gaps = 2/40 (5%)
Frame = +2
Query: 245 MWLSPNGTIRNILGGTVFREPILCQSIPRV--VPGWTKPI 358
MW SPNGTIRNIL GTVFREPILC+++PR+ VP +P+
Sbjct: 1 MWRSPNGTIRNILNGTVFREPILCKNVPRILSVPDGAEPV 40
>UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: NADP-dependent
isocitrate dehydrogenase protein - Rhizobium etli
(strain CFN 42 / ATCC 51251)
Length = 437
Score = 130 bits (313), Expect = 5e-29
Identities = 82/239 (34%), Positives = 126/239 (52%)
Frame = -3
Query: 730 HVVN*TMLVPYLGFIKLSLVVTLKNFFENVFETTIVTFQNGILRRQV*RPFFL*SYLKTG 551
HVV+ T+ V GF++L L L +F E+V E ++ ++G+L RQV RPF + G
Sbjct: 171 HVVDQTVFVGDPGFLELILEFGLVDFLEDVLEAAVIGLEDGVLGRQVDRPFAHQAVHHRG 230
Query: 550 MGKGPNRFVGIVHAHSNARSFKII*YTPLCRTISCSVNKFNLSGFRYNKILRLVLVAVRM 371
G+ +RFV +VH H NA + ++ + L+ ++ VLVA +
Sbjct: 231 AGEFADRFVEVVHGHGNAGARRVEDLLLDDGAVFTDELDRQLALAGELEVGCAVLVAESV 290
Query: 370 TAYHNRFRPTRHNPRDTLTQYRFAEYCTAQNVTDRSVRA*PHFLQLELFYSLFIRCDSSA 191
TA +R RP + R+ R AE A+NV+DR+VRA PHFL++E + FIR D A
Sbjct: 291 TADDDRLRPAGNEARNVAADDRLAEDDAAENVSDRAVRALPHFLEIEFLDAGFIRRDRCA 350
Query: 190 FDAHIML*NGMR*VDGDLIISGVTMREAQVKVKTIHLNIWKYQSLFDLSPHDACHLITI 14
D + +G+ VD L++ GV + + +V + I + I Q + D P DACH I +
Sbjct: 351 LDTDAVFLDGVGGVDRHLVVGGVAIFDREVVIVDIEVEIRMDQLILDELPDDACHFIAV 409
>UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=2; Rhodobacteraceae|Rep: NADP-dependent
isocitrate dehydrogenase protein - Sagittula stellata
E-37
Length = 459
Score = 124 bits (298), Expect = 3e-27
Identities = 81/241 (33%), Positives = 121/241 (50%)
Frame = -3
Query: 733 HHVVN*TMLVPYLGFIKLSLVVTLKNFFENVFETTIVTFQNGILRRQV*RPFFL*SYLKT 554
HHVV+ +LVP ++L + L + E V E +V +NG+L RQV RP + ++
Sbjct: 201 HHVVDQPVLVPDALRLELLGKLRLVDLLEQVLEPPVVGLENGVLGRQVHRPAQRQTVVQR 260
Query: 553 GMGKGPNRFVGIVHAHSNARSFKII*YTPLCRTISCSVNKFNLSGFRYNKILRLVLVAVR 374
G GK +R V +VHAH + +++ + L+ +I LVLVA
Sbjct: 261 GAGKVADRLVLVVHAHVDPGIGRVVDLALDHLAVGAFPFHRQLARRGEVEIRGLVLVAEG 320
Query: 373 MTAYHNRFRPTRHNPRDTLTQYRFAEYCTAQNVTDRSVRA*PHFLQLELFYSLFIRCDSS 194
+ A+H+ P RH R R AE AQ+V DR+V PH L+ E +L +R D
Sbjct: 321 VPAHHDGRGPARHEARHVAADDRLAEDDAAQDVADRAVGRLPHLLETEFLDTLLVRGDRR 380
Query: 193 AFDAHIML*NGMR*VDGDLIISGVTMREAQVKVKTIHLNIWKYQSLFDLSPHDACHLITI 14
AFD L VDGDL+ V + + ++ VK + + + + Q D SPHDA HL+ +
Sbjct: 381 AFDRDANLLRLFGGVDGDLVPGPVPLLDPEIVVKQVQVEVRQDQLFLDESPHDAGHLVAV 440
Query: 13 H 11
H
Sbjct: 441 H 441
>UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4;
Eukaryota|Rep: Isocitrate dehydrogenase - Saltugilia
latimeri
Length = 158
Score = 116 bits (279), Expect = 6e-25
Identities = 50/70 (71%), Positives = 60/70 (85%)
Frame = +2
Query: 521 TDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKI 700
TDESI SFA +S A +KKWPLYLSTKNTILK+YDGRFKDIF+EV++ +K+K++ A I
Sbjct: 1 TDESIYSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAGI 60
Query: 701 WYEHRLIDDM 730
WYEHRLIDDM
Sbjct: 61 WYEHRLIDDM 70
>UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC09598 protein - Schistosoma
japonicum (Blood fluke)
Length = 129
Score = 113 bits (271), Expect = 6e-24
Identities = 59/87 (67%), Positives = 66/87 (75%)
Frame = -1
Query: 309 IGSRNTVPPKMLRIVPFGLSHIFFNLNSSTLCSSGVIVAHLMPTLCFRMACAESMVT*SS 130
+GSR TVPP++LRIVPFG SHIFF LNS T CSSGV+VAHL+PTL F +A A S+VT S
Sbjct: 1 MGSRKTVPPRILRIVPFGDSHIFFKLNSLTRCSSGVMVAHLIPTLYFLIASAPSIVTWSL 60
Query: 129 VASRCGRPKSK*RQSTLTYGNISLSLI 49
V SR GRPKSK QST GNIS I
Sbjct: 61 VRSRLGRPKSKYLQSTSINGNISCCFI 87
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 105 bits (253), Expect = 9e-22
Identities = 67/260 (25%), Positives = 126/260 (48%), Gaps = 12/260 (4%)
Frame = +2
Query: 2 LSXMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNV 181
L + GDEM ++ + +I ++ + + ++ + DL HR T+ QV ++ A+ K+ V
Sbjct: 11 LVILHGDEMAQVAFEEILKKFVTTRLAIELIEIDLSAEHRFLTNGQVIFEAIEALKKYGV 70
Query: 182 GIKCATITPDEQRVEEFKLKKMWLS-----------PNGTIRNILGGTVFREPILCQSIP 328
G+K A +T + ++++ K LS PNG IR +GG + RE I Q++
Sbjct: 71 GVKNAGMTVNREQLDAMLEKHPELSQSRLDPLATKSPNGAIRKGIGGNITREDIQFQNLR 130
Query: 329 RVVPGWT-KPIVIGRHAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERRVLYDFKTPGVA 505
P W + I + +G + + + G V+L++ + G D K
Sbjct: 131 VRKPDWIDRDIDVDTMDNGGIKDSYNELSSSTGVVKLLFVGKSGNPVELHRRDVKKGDPW 190
Query: 506 MGMYNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKF 685
+ N ++++AH FQ A+ +K YL K+T++ YDG + E +++ +YK +F
Sbjct: 191 LLATNDIADVKAWAHRFFQRAIDEKRDAYLGLKDTVIAGYDGVMRAAIEAIYKQEYKKQF 250
Query: 686 DEAKIWYEHRLIDDMVAQAI 745
+ I Y + L+D A+ +
Sbjct: 251 EAVGINYYYELVDAQAARIV 270
>UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 141
Score = 94.3 bits (224), Expect = 3e-18
Identities = 54/89 (60%), Positives = 62/89 (69%)
Frame = -1
Query: 279 MLRIVPFGLSHIFFNLNSSTLCSSGVIVAHLMPTLCFRMACAESMVT*SSVASRCGRPKS 100
MLRIVP G HIF +LNS T SS VIVAHL+PTLC R+A A S VT S VASR +S
Sbjct: 1 MLRIVPLGEGHIFLSLNSLTRASSAVIVAHLIPTLCSRIAQAASKVTQSLVASRFSIERS 60
Query: 99 K*RQSTLTYGNISLSLILAHMMRVISSPS 13
+ S GN+SLSLI+ M+RVISSPS
Sbjct: 61 QYLISAEINGNMSLSLIIFQMIRVISSPS 89
>UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3;
Ostreococcus|Rep: COG0538: Isocitrate dehydrogenases -
Ostreococcus tauri
Length = 429
Score = 89.8 bits (213), Expect = 6e-17
Identities = 75/249 (30%), Positives = 116/249 (46%), Gaps = 7/249 (2%)
Frame = +2
Query: 17 GDEMTRIMWAKIKERLIFPYVKVDCLY-FDLGLPHRDATDDQVTIDSAHAILKHNVGIKC 193
G+EMT + I+ R I P V V FDL +RD T+D+V D A + K
Sbjct: 36 GEEMTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLRDVIEAGKRIKAIFKE 95
Query: 194 ATITPDEQRVEEFKLKKMWLSPNGTIRNILGG-TVFREPILCQSIPRVVPGWTKPIVIGR 370
T+TP +V+ L+K W SPNG +R G T+ R+ I I V G+ KP++ R
Sbjct: 96 PTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTI---HIDGVELGYKKPVLFER 152
Query: 371 HAHGDQYKAQDFVVPKPGKVELVYTTRDG-TTERRVLYDFK----TPGVAMGMYNTDESI 535
HA G +Y A V K GK+ +T +G + V+ D + + +N +++
Sbjct: 153 HAVGGEYSAGYKNVGK-GKLTTTFTPSEGPDAGKTVVVDEREIVDEEAAVVTYHNPYDNV 211
Query: 536 RSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKIWYEHR 715
A F L+ K Y+ TK T+ K + F I VF ++K +F A + E
Sbjct: 212 HDLARFFFGRCLEAKVTPYVVTKKTVFK-WQEPFWQIMRTVFDEEFKAQFVAAGVMKEGE 270
Query: 716 LIDDMVAQA 742
+ +++ A
Sbjct: 271 ELVHLLSDA 279
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 51.2 bits (117), Expect = 3e-05
Identities = 54/197 (27%), Positives = 90/197 (45%)
Frame = +2
Query: 98 FDLGLPHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRN 277
+DL L +R AT ++V ++A A+ +H G+K ATITP E R + SPN +R
Sbjct: 41 YDLSLENRRATSNRVVYEAAAAMREHGYGLKAATITP-EGRGDVG-------SPNAILRR 92
Query: 278 ILGGTVFREPILCQSIPRVVPGWTKPIVIGRHAHGDQYKAQDFVVPKPGKVELVYTTRDG 457
+ GTV + G T PI + R A D Y+A+++ + G +G
Sbjct: 93 EIDGTVILRTGRPLPGVETIGGITAPIAVVRMATEDAYEAKEW---REG---------EG 140
Query: 458 TTERRVLYDFKTPGVAMGMYNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRF 637
ER F+T Y + + R+ A +F++A Q ++ K T+ Y+G
Sbjct: 141 DEERA----FRT------TYISARNCRATAEFAFRLARQMGALVFGGPKWTVSPTYEGLL 190
Query: 638 KDIFEEVFQSDYKTKFD 688
K+ +E + + +D
Sbjct: 191 KEAMDEAARRNPDVPYD 207
>UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza
sativa|Rep: Isocitrate dehydrogenase - Oryza sativa
(Rice)
Length = 61
Score = 42.7 bits (96), Expect = 0.009
Identities = 16/25 (64%), Positives = 21/25 (84%)
Frame = +2
Query: 14 DGDEMTRIMWAKIKERLIFPYVKVD 88
DGDEMTRI W IK++LIFP++ +D
Sbjct: 35 DGDEMTRIFWQSIKDKLIFPFLDLD 59
>UniRef50_Q757T0 Cluster: Probable E3 ubiquitin-protein ligase HUL4;
n=1; Eremothecium gossypii|Rep: Probable E3
ubiquitin-protein ligase HUL4 - Ashbya gossypii (Yeast)
(Eremothecium gossypii)
Length = 839
Score = 36.7 bits (81), Expect = 0.61
Identities = 23/56 (41%), Positives = 32/56 (57%), Gaps = 3/56 (5%)
Frame = +2
Query: 587 LYLSTKNTILK--RYDGR-FKDIFEEVFQSDYKTKFDEAKIWYEHRLIDDMVAQAI 745
LY T +LK YDG F+DIF F++ + +FDE+KI Y +L D QA+
Sbjct: 614 LYPETGTNMLKMLEYDGEDFEDIFALTFETCFPDRFDESKIHY-RQLCPDGSTQAV 668
>UniRef50_A0C1D3 Cluster: Chromosome undetermined scaffold_141,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_141,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 490
Score = 35.1 bits (77), Expect = 1.9
Identities = 18/61 (29%), Positives = 32/61 (52%)
Frame = +2
Query: 503 AMGMYNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTK 682
++ + ++ I + H SF++ L K +STKN ++ Y+G + FE Q D+K
Sbjct: 101 SLSIITSNNIINQWRHYSFKLPLPKLNNQDVSTKNQKIRAYNGSYSINFESTQQRDFKYV 160
Query: 683 F 685
F
Sbjct: 161 F 161
>UniRef50_Q91L92 Cluster: ORF160; n=1; Shrimp white spot syndrome
virus|Rep: ORF160 - White spot syndrome virus (WSSV)
Length = 786
Score = 33.9 bits (74), Expect = 4.3
Identities = 19/55 (34%), Positives = 29/55 (52%)
Frame = +2
Query: 527 ESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDE 691
+SIR F S Q +QK+W ++ N ++ YDG EE+F+ YK +E
Sbjct: 702 QSIRKFIGESMQ-HVQKEWSSAVNNGNRGVENYDGLNAQFSEELFELLYKLIIEE 755
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 33.9 bits (74), Expect = 4.3
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Frame = +2
Query: 491 TPGVAMGM-YNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQS 667
TP VA+ + T ++ AH++F +A + + + K +L G F+D+ EV Q
Sbjct: 156 TPDVALAVGVVTRKACERIAHTAFALARTRGRHVTIVHKANVLSMTTGLFRDVCREVGQR 215
Query: 668 DYKTKFDEAKIWYEHRLIDDMVAQAIK 748
DY + +I EH +D M A ++
Sbjct: 216 DY----PDVRIDDEH--VDAMTAHLVR 236
>UniRef50_A0KSD7 Cluster: Putative uncharacterized protein; n=2;
Proteobacteria|Rep: Putative uncharacterized protein -
Shewanella sp. (strain ANA-3)
Length = 112
Score = 33.9 bits (74), Expect = 4.3
Identities = 15/52 (28%), Positives = 27/52 (51%)
Frame = +2
Query: 200 ITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKP 355
+T ++ VEE +++MW+ G I NI G + +P + I + W +P
Sbjct: 53 VTENDAGVEEVNVERMWVIVKGRIDNIYRGQLDNDPYCTEEIRSGMEVWFQP 104
>UniRef50_Q61R47 Cluster: Putative uncharacterized protein CBG06736;
n=1; Caenorhabditis briggsae|Rep: Putative
uncharacterized protein CBG06736 - Caenorhabditis
briggsae
Length = 394
Score = 33.1 bits (72), Expect = 7.5
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 6/109 (5%)
Frame = +2
Query: 410 VPKPG--KVELVYTTRDGTTERRVLYDFKTPGVAMGMYNTDESIRSFAHSSFQVALQKKW 583
+PK G V + + ++ ++ + DF+ M+ TD +++ F+H A +
Sbjct: 43 IPKKGGITVSVEFWIQEISSISEMTNDFEMEIYINEMW-TDPNLK-FSHLG---ACKANL 97
Query: 584 PLYLSTKNTILKR----YDGRFKDIFEEVFQSDYKTKFDEAKIWYEHRL 718
LY T N + K + +F +I+E FQ+ + T FD +W +RL
Sbjct: 98 TLYEQTLNKLWKPNTCFVNSKFAEIYESPFQNVFLTLFDNGTVWVNYRL 146
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 800,851,479
Number of Sequences: 1657284
Number of extensions: 17105344
Number of successful extensions: 42991
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 41531
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 42972
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 61734884250
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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