Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-0302
(600 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4; Euteleost... 231 1e-59
UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;... 202 5e-51
UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19; Magnol... 178 7e-44
UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to Ecdysone-i... 177 1e-43
UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11; Clostrid... 161 2e-38
UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4; Eutheria|... 159 3e-38
UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12; Bacteria... 156 3e-37
UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4; Cyanobact... 152 5e-36
UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12; Firmic... 147 2e-34
UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6; Bacteria|... 147 2e-34
UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1; ... 144 1e-33
UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14; Bacill... 144 2e-33
UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17; Bacter... 141 1e-32
UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9; Bacilli... 138 9e-32
UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6; Acti... 136 5e-31
UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4; Thermotog... 135 7e-31
UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5; Bacillace... 135 9e-31
UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;... 134 2e-30
UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2; ... 134 2e-30
UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia ... 134 2e-30
UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140; Bacteri... 134 2e-30
UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate ... 133 3e-30
UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobu... 130 2e-29
UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8; Lactoba... 129 4e-29
UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila melanogaster|... 129 6e-29
UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibac... 128 1e-28
UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2; Propionib... 128 1e-28
UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2; Desulfovi... 128 1e-28
UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1; Corynebac... 127 2e-28
UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2; ... 125 7e-28
UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate de... 123 3e-27
UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4; Lactobaci... 123 3e-27
UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula... 123 3e-27
UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13; Firmic... 120 2e-26
UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;... 120 3e-26
UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1; Ther... 118 8e-26
UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7; Bacteria|... 118 1e-25
UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizop... 118 1e-25
UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2; Phaeospha... 117 2e-25
UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2; Bacteria|... 116 4e-25
UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14; Thermoprote... 115 7e-25
UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 115 1e-24
UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1; Lept... 114 1e-24
UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular org... 114 2e-24
UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28; Bacteroidet... 113 2e-24
UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant... 113 4e-24
UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD bindi... 111 9e-24
UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1; ... 111 2e-23
UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=... 109 5e-23
UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3; Bifidob... 109 6e-23
UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacte... 108 9e-23
UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2; Euryarchaeot... 108 9e-23
UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18; Bacter... 108 9e-23
UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1; Staphyloc... 108 1e-22
UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5; Gammaproteob... 107 3e-22
UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2; Gammaproteo... 105 6e-22
UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4; Pezizomyc... 105 8e-22
UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to Ecdysone-i... 105 1e-21
UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4; Bacteria|... 104 1e-21
UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1; Ce... 104 1e-21
UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1; ... 103 3e-21
UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1; Clostri... 103 4e-21
UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4; Thermoplasma... 102 6e-21
UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular or... 102 6e-21
UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6; Mollicute... 102 6e-21
UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 102 7e-21
UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant... 101 1e-20
UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3; Fusobacte... 101 1e-20
UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1; Lactobaci... 101 1e-20
UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2; Pl... 101 2e-20
UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=... 101 2e-20
UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacte... 101 2e-20
UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3; Clostridi... 100 3e-20
UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 100 3e-20
UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:... 100 5e-20
UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate dehydrog... 99 9e-20
UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1; ... 97 4e-19
UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7; Halobacteria... 96 5e-19
UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|R... 96 6e-19
UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein OJA121... 95 9e-19
UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 95 1e-18
UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3; Lactoco... 94 2e-18
UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 94 3e-18
UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like prot... 92 8e-18
UniRef50_O26290 Cluster: Malate dehydrogenase; n=2; Methanobacte... 92 8e-18
UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3; Acti... 91 1e-17
UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1; Asp... 91 1e-17
UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Re... 90 4e-17
UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular o... 89 7e-17
UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12; Ca... 89 7e-17
UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4; Epsilonprote... 89 1e-16
UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex ae... 89 1e-16
UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2... 88 1e-16
UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;... 88 1e-16
UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasm... 88 1e-16
UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep: Li... 88 2e-16
UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1; Bl... 88 2e-16
UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3; Methanomi... 87 2e-16
UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;... 87 3e-16
UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 87 4e-16
UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococ... 85 9e-16
UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17; Apicompl... 85 9e-16
UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomon... 85 2e-15
UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene en... 84 2e-15
UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-... 84 3e-15
UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5; Methanococcu... 81 1e-14
UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;... 80 3e-14
UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium ... 80 3e-14
UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|R... 80 5e-14
UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 78 1e-13
UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10; Campylob... 78 1e-13
UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3; Eimeriorina... 78 2e-13
UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-... 77 2e-13
UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter... 77 3e-13
UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 77 4e-13
UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 76 6e-13
UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 74 2e-12
UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 74 2e-12
UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1; Lac... 73 4e-12
UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1; ... 73 4e-12
UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2; Meth... 70 4e-11
UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 70 5e-11
UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6; Plasmodi... 67 3e-10
UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-... 66 5e-10
UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4; Bacteroidale... 63 4e-09
UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5; Bacteroidale... 63 6e-09
UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;... 63 6e-09
UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH - ... 62 7e-09
UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 62 1e-08
UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 60 4e-08
UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 56 8e-07
UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1... 55 1e-06
UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1; ... 54 2e-06
UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 53 4e-06
UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1; St... 53 6e-06
UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3; Le... 53 6e-06
UniRef50_Q1U8H4 Cluster: L-lactate dehydrogenase; n=2; Lactobaci... 50 4e-05
UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=... 48 2e-04
UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa ... 47 3e-04
UniRef50_Q01JC3 Cluster: Malate dehydrogenase; n=8; cellular org... 40 0.059
UniRef50_Q75AT4 Cluster: ADL164Cp; n=2; Saccharomycetales|Rep: A... 40 0.059
UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;... 39 0.078
UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces cere... 38 0.24
UniRef50_Q0JBC2 Cluster: Os04g0542900 protein; n=8; Magnoliophyt... 37 0.32
UniRef50_UPI0000DB7CDC Cluster: PREDICTED: similar to CTD (carbo... 36 0.73
UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5; Protostomia|... 36 0.73
UniRef50_UPI0000E45EC5 Cluster: PREDICTED: similar to CG10662-PA... 34 2.2
UniRef50_A0QSN0 Cluster: Ftsk/spoiiie family protein; n=1; Mycob... 34 2.2
UniRef50_Q2QQV8 Cluster: Retrotransposon protein, putative, uncl... 34 2.2
UniRef50_A2YRW8 Cluster: Putative uncharacterized protein; n=2; ... 34 2.2
UniRef50_Q4Q910 Cluster: Putative uncharacterized protein; n=3; ... 34 2.2
UniRef50_Q8EYH1 Cluster: Methyl-accepting chemotaxis protein; n=... 34 2.9
UniRef50_A1S187 Cluster: UBA/THIF-type NAD/FAD binding protein; ... 34 2.9
UniRef50_Q15ST6 Cluster: UBA/THIF-type NAD/FAD binding fold; n=2... 33 3.9
UniRef50_A0W7C0 Cluster: Diguanylate cyclase/phosphodiesterase w... 33 3.9
UniRef50_P40925 Cluster: Malate dehydrogenase, cytoplasmic; n=12... 33 3.9
UniRef50_Q6NYY8 Cluster: Smox protein; n=12; Coelomata|Rep: Smox... 33 6.8
UniRef50_Q8FY97 Cluster: Prephenate dehydrogenase; n=75; Bacteri... 33 6.8
UniRef50_Q577J1 Cluster: Alcohol dehydrogenase, zinc-containing;... 33 6.8
UniRef50_Q7G3D9 Cluster: Retrotransposon protein, putative, uncl... 33 6.8
UniRef50_Q6ZCA3 Cluster: Putative uncharacterized protein P0547A... 33 6.8
UniRef50_Q74ZH8 Cluster: AGR229Wp; n=2; Eremothecium gossypii|Re... 33 6.8
UniRef50_Q4P6B5 Cluster: Putative uncharacterized protein; n=1; ... 33 6.8
UniRef50_Q4RTQ4 Cluster: Chromosome 2 SCAF14997, whole genome sh... 32 9.0
UniRef50_Q10YD5 Cluster: Monooxygenase, FAD-binding; n=4; Tricho... 32 9.0
UniRef50_Q091H7 Cluster: Oxidoreductase; n=2; Myxococcales|Rep: ... 32 9.0
>UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4;
Euteleostomi|Rep: L-lactate dehydrogenase - Tetraodon
nigroviridis (Green puffer)
Length = 360
Score = 231 bits (564), Expect = 1e-59
Identities = 108/166 (65%), Positives = 138/166 (83%), Gaps = 1/166 (0%)
Frame = +3
Query: 63 LKKLFQPVHEKVDET-WSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMM 239
L+KL P+ + E +KVT+VGVGQVGMA A S+L +++ + +ALVD+M D+LKGE+M
Sbjct: 5 LQKLISPLADSPSEPPRNKVTVVGVGQVGMACAISILLRDLADELALVDVMEDRLKGELM 64
Query: 240 DLQHGSAFMRNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQ 419
DLQHGS F++ +KI + DYS+TA S++ VVTAGVRQ+EGESRL+LVQRN +V K IIPQ
Sbjct: 65 DLQHGSLFLKTSKIVADKDYSVTANSRLVVVTAGVRQQEGESRLNLVQRNVNVFKSIIPQ 124
Query: 420 LIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+IKYSP+ L++ SNPVD+LTYVTWK+SGLPKHRVIGSGTNLDSAR
Sbjct: 125 IIKYSPNCTLIVVSNPVDVLTYVTWKLSGLPKHRVIGSGTNLDSAR 170
>UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;
Eukaryota|Rep: L-lactate dehydrogenase C chain - Homo
sapiens (Human)
Length = 332
Score = 202 bits (493), Expect = 5e-51
Identities = 95/164 (57%), Positives = 124/164 (75%)
Frame = +3
Query: 66 KKLFQPVHEKVDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDL 245
++L + + E + + K+TIVG G VGMA A S+L +++ + +ALVD+ DKLKGEMMDL
Sbjct: 6 EQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKGEMMDL 65
Query: 246 QHGSAFMRNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLI 425
QHGS F +KI S DYS++A S+I +VTAG RQ+EGE+RL LVQRN ++K IIP ++
Sbjct: 66 QHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIV 125
Query: 426 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
YSPD +++ SNPVDILTY+ WKISGLP RVIGSG NLDSAR
Sbjct: 126 HYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSAR 169
>UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19;
Magnoliophyta|Rep: L-lactate dehydrogenase A - Hordeum
vulgare (Barley)
Length = 356
Score = 178 bits (434), Expect = 7e-44
Identities = 80/149 (53%), Positives = 115/149 (77%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+K++++G G VGMA A ++LTQN+ + IALVD + DKL+GE +DLQH +AF+ +I S
Sbjct: 44 TKISVIGAGNVGMAIAQTILTQNLADEIALVDALPDKLRGEALDLQHAAAFLPRVRI-SG 102
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
TD ++T S + +VTAG RQ GE+RL+L+QRN + ++I+P + ++SPD +L++ SNPV
Sbjct: 103 TDAAVTKNSDLVIVTAGARQIPGETRLNLLQRNVALYRKIVPPVAEHSPDALLLVVSNPV 162
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D+LTYV WK+SG P RVIGSGTNLDS+R
Sbjct: 163 DVLTYVAWKLSGFPASRVIGSGTNLDSSR 191
>UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=2;
Apocrita|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 409
Score = 177 bits (432), Expect = 1e-43
Identities = 81/156 (51%), Positives = 116/156 (74%)
Frame = +3
Query: 90 EKVDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR 269
E V + KVT+VG G VG+A +++ Q +T ++A+VD KL+GE MD HG + +
Sbjct: 90 EPVQDCCHKVTVVGSGMVGVAIVNALIFQKITAHVAMVDAFPKKLEGEGMDYCHGLSLIE 149
Query: 270 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 449
+ +I TD+ IT+ SK+ V+ AG RQ +GESRLDLVQRN+++LK IIP L+ YSP+ ++
Sbjct: 150 SPRIDFDTDFCITSNSKVIVLAAGARQMKGESRLDLVQRNSEILKSIIPTLVGYSPNAVI 209
Query: 450 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
++ SNPVDIL+++TWKISGLP RVIG+GT++DSAR
Sbjct: 210 LVVSNPVDILSWLTWKISGLPASRVIGTGTHVDSAR 245
>UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
perfringens
Length = 317
Score = 161 bits (390), Expect = 2e-38
Identities = 71/155 (45%), Positives = 112/155 (72%)
Frame = +3
Query: 96 VDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA 275
+ E +K++I+G G VG AF+++ + + I +VD+ DK E MDL G+AF+++
Sbjct: 2 IREKTNKISIIGAGFVGSTTAFALMQDGLASEIVIVDINKDKAHAEAMDLAQGAAFVKSV 61
Query: 276 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 455
I+S DY+ T S I ++TAGV + GE+RLD++ +N + + I+P+++KYSP++IL++
Sbjct: 62 DIKSG-DYADTKDSDIVIITAGVGPKPGETRLDIINKNLKIFQSIVPEVVKYSPNSILLV 120
Query: 456 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
SNPVDILTY+T+K+SG PK RVIGSGT LD++R+
Sbjct: 121 VSNPVDILTYITYKLSGFPKERVIGSGTVLDTSRL 155
>UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4;
Eutheria|Rep: L-lactate dehydrogenase - Homo sapiens
(Human)
Length = 253
Score = 159 bits (387), Expect = 3e-38
Identities = 75/148 (50%), Positives = 103/148 (69%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV+I G G VGMA A S+L + +++ +A VD+ KLKGE MDLQH S FM+ + I S
Sbjct: 71 KVSITGTGSVGMACATSILLKGLSDELAFVDLDEGKLKGETMDLQHDSPFMKMSNIVCSK 130
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
DY +TA + ++TAG R+ +GE R +LV++N + K +I +++ SP L+I SNPVD
Sbjct: 131 DYLVTANPHLVIITAGARREKGEMRFNLVRQNVAIFKLMISSIVQQSPLCKLIIVSNPVD 190
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
ILTYV WK+S PK+RVIGSG NLD+ R
Sbjct: 191 ILTYVAWKLSAFPKNRVIGSGCNLDTVR 218
>UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12;
Bacteria|Rep: L-lactate dehydrogenase - Clostridium
tetani
Length = 316
Score = 156 bits (379), Expect = 3e-37
Identities = 70/148 (47%), Positives = 107/148 (72%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K++I+G G VG A++++ + + + I +VD+ +K KGE MDL HG +F++ I +
Sbjct: 7 KISIIGSGFVGSTTAYALMMEGLASEIVIVDINKEKAKGEAMDLSHGVSFVKPVDIIAG- 65
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
DY T S I ++TAG + GE+RLDL+ +N ++ K I+P+++KYSP +IL++ SNPVD
Sbjct: 66 DYEDTKDSDIVIITAGAGPKPGETRLDLINKNYEIFKGIVPEVVKYSPKSILLVVSNPVD 125
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
ILTYVT+K+SG P+ RVIGSGT LD++R
Sbjct: 126 ILTYVTYKLSGFPQERVIGSGTVLDTSR 153
>UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4;
Cyanobacteria|Rep: L-lactate dehydrogenase - Gloeobacter
violaceus
Length = 330
Score = 152 bits (369), Expect = 5e-36
Identities = 73/148 (49%), Positives = 106/148 (71%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K IVG G VGMA A+SML QN + + LVD+ K++GE+MDL HG F+ + +++ T
Sbjct: 22 KGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEGEVMDLVHGIPFVEPSVVRAGT 81
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+ G + V+TAG RQREGE+RL LVQRN ++ + +I +++++ P+ IL++ SNPVD
Sbjct: 82 -LADCRGVDVVVITAGARQREGETRLSLVQRNVEIFRGLIGEIMEHCPNAILLVVSNPVD 140
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
++TYV K++GLP RVIGSGT LD+AR
Sbjct: 141 VMTYVAMKLAGLPPSRVIGSGTVLDTAR 168
>UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12;
Firmicutes|Rep: L-lactate dehydrogenase 2 - Bacillus
anthracis
Length = 314
Score = 147 bits (357), Expect = 2e-34
Identities = 74/149 (49%), Positives = 98/149 (65%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
++V +VG G VG + A+SM+ Q V LVD+ K +GE MDL H F + S
Sbjct: 6 NRVVLVGTGAVGCSYAYSMINQGVAEEFVLVDVNEAKAEGEAMDLSHAVPFSPSPTKVWS 65
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
Y+ + + V+TAG+ Q+ GE+RLDLV++NT + KQI+ ++ D I +IA+NPV
Sbjct: 66 GSYADCKDADLVVITAGLPQKPGETRLDLVEKNTKIFKQIVRGIMDSGFDGIFLIATNPV 125
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
DILTYVTWK SGLPK RVIGSGT LDSAR
Sbjct: 126 DILTYVTWKESGLPKERVIGSGTTLDSAR 154
>UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6;
Bacteria|Rep: L-lactate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 321
Score = 147 bits (356), Expect = 2e-34
Identities = 67/148 (45%), Positives = 104/148 (70%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
++ +VG+G VG + AF++L + + I L+D K +GE MDL H F +I +
Sbjct: 12 RIAVVGLGNVGASFAFALLQRRLAAEIVLIDANHKKAEGEAMDLNHAVPFGAATRIWAG- 70
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+Y+ G+ + V+TAG QR GE+RL L+ RN + +QI+P+++K++PD +L+IA+NPVD
Sbjct: 71 EYADCRGAAVTVITAGAAQRPGETRLQLLDRNLAIFQQIVPEVVKHNPDGLLLIATNPVD 130
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
I++Y ++KISGLP HRV+GSGT LD+AR
Sbjct: 131 IISYASYKISGLPAHRVLGSGTILDTAR 158
>UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 323
Score = 144 bits (350), Expect = 1e-33
Identities = 65/149 (43%), Positives = 100/149 (67%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV IVG G VG A+++L I L+D+ DK +GE+MDL H + F+ +I +
Sbjct: 14 KVVIVGAGYVGSTTAYTLLMNRAAAEIVLIDVDKDKTEGEVMDLVHAAPFLHQTRIWAG- 72
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKY-SPDTILVIASNPV 470
DY G+ + ++TAG Q+ G+SR++L Q N + K+I+P+++++ SPD +L++++NPV
Sbjct: 73 DYEDCKGASVIILTAGANQKPGQSRMELAQSNWGIFKEIVPKVVQHASPDALLLVSANPV 132
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D++TY K SG P H VIGSGT+LDSAR
Sbjct: 133 DVMTYAAVKFSGFPAHSVIGSGTSLDSAR 161
>UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14;
Bacillales|Rep: L-lactate dehydrogenase X - Bacillus
psychrosaccharolyticus
Length = 319
Score = 144 bits (348), Expect = 2e-33
Identities = 67/149 (44%), Positives = 95/149 (63%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
++V ++G G VG + AF++L Q++T + ++D+ DK G+ MDL HG F N
Sbjct: 7 NRVALIGAGSVGSSYAFALLNQSITEELVIIDVNEDKAMGDAMDLNHGKIFAPNPTKTWY 66
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+Y + I + AG Q+ GE+RLDLV++N + K ++ Q++ D I +IA+NPV
Sbjct: 67 GNYDDCKEADIVCICAGANQKPGETRLDLVEKNLKIFKSLVDQVMASGFDGIFLIATNPV 126
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
DILTY TWK SGLPK RVIGSGT LDS R
Sbjct: 127 DILTYATWKFSGLPKERVIGSGTILDSGR 155
>UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17;
Bacteria|Rep: L-lactate dehydrogenase 2 -
Bifidobacterium longum
Length = 320
Score = 141 bits (341), Expect = 1e-32
Identities = 62/150 (41%), Positives = 101/150 (67%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+K+ ++G G VG AF+ + + I L D+ ++++ E++D+QHGS+F I S
Sbjct: 9 TKLAVIGAGAVGSTLAFAAAQRGIAREIVLEDIAKERVEAEVLDMQHGSSFYPTVSIDGS 68
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
D I + + V+TAG RQ+ G+SRL+LV ++LK I+P L+K +P+ I ++ +NPV
Sbjct: 69 DDPEICRDADMVVITAGPRQKPGQSRLELVGATVNILKAIMPNLVKVAPNAIYMLITNPV 128
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DI T+V K++GLP++++ GSGTNLDSAR+
Sbjct: 129 DIATHVAQKLTGLPENQIFGSGTNLDSARL 158
>UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9;
Bacilli|Rep: L-lactate dehydrogenase 2 - Enterococcus
faecalis (Streptococcus faecalis)
Length = 317
Score = 138 bits (334), Expect = 9e-32
Identities = 70/149 (46%), Positives = 97/149 (65%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAF-MRNAKIQSS 290
KV I+G G VG + A+SM+ Q + N + LVD+ K +GE +DL G ++ N + +
Sbjct: 7 KVAIIGTGFVGTSIAYSMINQGIANELILVDIDKAKSEGEAIDLLDGVSWGQENVNVWAG 66
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DY + I V+TAG Q+ G+SRLDLV N +++K I+ ++K D ILVIASNPV
Sbjct: 67 -DYQDCQDADIVVITAGANQKPGQSRLDLVSINAEIMKTIVNNIMKSGFDGILVIASNPV 125
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D+LTYV W+ SGLP RVIG+GT LD+ R
Sbjct: 126 DVLTYVAWQASGLPVSRVIGTGTTLDTTR 154
>UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 329
Score = 136 bits (328), Expect = 5e-31
Identities = 62/159 (38%), Positives = 98/159 (61%)
Frame = +3
Query: 81 PVHEKVDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA 260
P +V KV+I+G G VG A A++ L + +AL D + K++ E++DL HGS
Sbjct: 9 PASPEVRSARPKVSIIGAGSVGTAIAYACLIRGSAGTLALYDTNSAKVRAEVLDLNHGSQ 68
Query: 261 FMRNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPD 440
F+ ++ S D ++TAGS I VVTAG +Q G+SRLDL N + + + PQL+++SPD
Sbjct: 69 FVPECRVGGSDDIAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTPQLLEHSPD 128
Query: 441 TILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+++ +NPVD++TY + ++ G+GT LDS+R
Sbjct: 129 AVVIFVTNPVDVVTYAASSVVDAQPGQIFGTGTVLDSSR 167
>UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4;
Thermotogaceae|Rep: L-lactate dehydrogenase - Thermotoga
maritima
Length = 319
Score = 135 bits (327), Expect = 7e-31
Identities = 64/149 (42%), Positives = 100/149 (67%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ IVG+G+VG + AF++L + + L+D+ + +G+ +DL HG+ F R A I +
Sbjct: 2 KIGIVGLGRVGSSTAFALLMKGFAREMVLIDVDKKRAEGDALDLIHGTPFTRRANIYAG- 60
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
DY+ GS + +V AGV Q+ GE+RL L+ RN V+K+I + KY+PD+I+++ +NPVD
Sbjct: 61 DYADLKGSDVVIVAAGVPQKPGETRLQLLGRNARVMKEIARNVSKYAPDSIVIVVTNPVD 120
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+LTY K SG+ +V GSGT LD+AR+
Sbjct: 121 VLTYFFLKESGMDPRKVFGSGTVLDTARL 149
>UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5;
Bacillaceae|Rep: L-lactate dehydrogenase -
Oceanobacillus iheyensis
Length = 321
Score = 135 bits (326), Expect = 9e-31
Identities = 64/150 (42%), Positives = 97/150 (64%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
++V ++G G VG++ AF+++ Q VT +A++D+ ADK G++MDL HG AF +
Sbjct: 9 NRVVLIGGGSVGVSYAFALMNQGVTEELAIIDLDADKALGDVMDLNHGKAFAPSLTNVWL 68
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+Y + I + AG Q+ GE+RLDLV++N + K+I+ ++ + I +IA+NPV
Sbjct: 69 GEYGDCKDADIVCICAGANQQSGETRLDLVEKNMKIFKEIVTDVMNSGFNGIFLIATNPV 128
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DILT SGLP HRVIGSGT LD+AR+
Sbjct: 129 DILTQAVISFSGLPPHRVIGSGTTLDTARL 158
>UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;
Clostridium|Rep: L-lactate dehydrogenase precursor -
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Length = 318
Score = 134 bits (324), Expect = 2e-30
Identities = 65/149 (43%), Positives = 94/149 (63%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
SKV I+G G VG +AAF+M + N + L+D+ +K GE MD+ HG FM + +
Sbjct: 8 SKVAIIGAGFVGASAAFTMALRQTANELVLIDVFKEKAIGEAMDINHGLPFMGQMSLYAG 67
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DYS + VVTAG ++ GE+RLDL ++N + K++ ++KY ++++ SNPV
Sbjct: 68 -DYSDVKDCDVIVVTAGANRKPGETRLDLAKKNVMIAKEVTQNIMKYYNHGVILVVSNPV 126
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
DI+TY+ K SGLP +VIGSGT LDS R
Sbjct: 127 DIITYMIQKWSGLPVGKVIGSGTVLDSIR 155
>UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2;
Ascomycota|Rep: Probable L-lactate dehydrogenase -
Schizosaccharomyces pombe (Fission yeast)
Length = 330
Score = 134 bits (324), Expect = 2e-30
Identities = 61/148 (41%), Positives = 93/148 (62%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ IVG G VG AF++L + I ++D+ K +GE MDL H + ++
Sbjct: 22 KIVIVGAGNVGSTTAFTLLLSGLAAEIVIIDLNKKKAEGEAMDLNHAAPLSHETRVYLG- 80
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
DY + V+TAG Q+ GE+R+DL++ N + K+I+ ++ KY+ D IL++A+NPVD
Sbjct: 81 DYKDCKDATAVVITAGKNQKPGETRMDLLKANISIFKEILREVTKYTKDAILLVATNPVD 140
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+LTY T K++G P RVIGSGT +D+AR
Sbjct: 141 VLTYATLKLTGFPAERVIGSGTIIDTAR 168
>UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia
burgdorferi group|Rep: L-lactate dehydrogenase -
Borrelia burgdorferi (Lyme disease spirochete)
Length = 316
Score = 134 bits (324), Expect = 2e-30
Identities = 66/152 (43%), Positives = 101/152 (66%), Gaps = 2/152 (1%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQN-VTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQ 284
+KV ++G G VG + A+++ N + + + ++D+ +K KGE+MDL HG F++ N +
Sbjct: 5 NKVVLIGAGGVGSSFAYALTIDNSLVHELVIIDVNENKAKGEVMDLNHGQMFLKKNINVL 64
Query: 285 SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
T Y A + I V+TAG+ Q+ GE+RLDLV +N+ + K II ++ D I V+ASN
Sbjct: 65 FGT-YKDCANADIVVITAGLNQKPGETRLDLVDKNSKIFKDIITNVVSSGFDGIFVVASN 123
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
PVDI+TYVT K S P H+VIG+GT LD++R+
Sbjct: 124 PVDIMTYVTMKYSKFPIHKVIGTGTILDTSRL 155
>UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140;
Bacteria|Rep: L-lactate dehydrogenase - Streptococcus
pneumoniae
Length = 328
Score = 134 bits (323), Expect = 2e-30
Identities = 66/150 (44%), Positives = 99/150 (66%), Gaps = 2/150 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDM--MADKLKGEMMDLQHGSAFMRNAKIQS 287
KV +VG G VG + AF+++ Q + + ++++ + +K G+ +DL H AF KI +
Sbjct: 9 KVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAFTSPKKIYA 68
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
+ YS A + + V+TAG Q+ GE+RLDLV +N + K I+ Q+++ I ++A+NP
Sbjct: 69 A-QYSDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANP 127
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
VD+LTY TWK SG PK RVIGSGT+LDSAR
Sbjct: 128 VDVLTYSTWKFSGFPKERVIGSGTSLDSAR 157
>UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate
dehydrogenase A chain (LDH-A) (LDH muscle subunit)
(LDH-M); n=2; Apis mellifera|Rep: PREDICTED: similar to
L-lactate dehydrogenase A chain (LDH-A) (LDH muscle
subunit) (LDH-M) - Apis mellifera
Length = 348
Score = 133 bits (321), Expect = 3e-30
Identities = 60/154 (38%), Positives = 96/154 (62%)
Frame = +3
Query: 96 VDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA 275
VD K+ IVG G G+A ++L + + + + +D+ + K E D+ HG+AF+ N
Sbjct: 28 VDGHRVKIVIVGSGYTGVAIGIAILFKRLASELVFIDVNEELAKAEAEDISHGAAFLGNP 87
Query: 276 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 455
KI + DYS+ + +CV+T G R + L+++N ++ K +IP++ KY+P++IL+I
Sbjct: 88 KIIGTKDYSLARDATVCVITIGDRSTNEQDPSTLLEQNLNIFKDVIPKVCKYAPNSILLI 147
Query: 456 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+ PVDIL+Y K+SG P HRV+G GT LDS R
Sbjct: 148 VTAPVDILSYAAMKLSGFPPHRVVGLGTFLDSCR 181
>UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobus
fulgidus|Rep: Malate dehydrogenase - Archaeoglobus
fulgidus
Length = 294
Score = 130 bits (314), Expect = 2e-29
Identities = 61/150 (40%), Positives = 97/150 (64%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQSS 290
K+ VG G+VG +AF+ L + IALVD+ D GE MDL H +A + + KI
Sbjct: 2 KLGFVGAGRVGSTSAFTCLLNLDVDEIALVDIAEDLAVGEAMDLAHAAAGIDKYPKIVGG 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DYS+ GS+I VVTAG+ ++ G +RLDL +N ++K I ++++ +P++ +++ +NP+
Sbjct: 62 ADYSLLKGSEIIVVTAGLARKPGMTRLDLAHKNAGIIKDIAKKIVENAPESKILVVTNPM 121
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D++TY+ WK SG P++ V G G LDS R+
Sbjct: 122 DVMTYIMWKESGKPRNEVFGMGNQLDSQRL 151
>UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8;
Lactobacillus|Rep: L-lactate dehydrogenase 2 -
Lactobacillus plantarum
Length = 309
Score = 129 bits (312), Expect = 4e-29
Identities = 64/155 (41%), Positives = 102/155 (65%)
Frame = +3
Query: 96 VDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA 275
+D+ KV IVG G VG + AFS++ + + +VD++ +G++ DL+ +AF
Sbjct: 1 MDKKQRKVVIVGDGSVGSSFAFSLVQNCALDELVIVDLVKTHAEGDVKDLEDVAAFTNAT 60
Query: 276 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 455
I + +Y+ + I V+TAGV ++ GESRLDL+ RNT +L+ I+ ++ + VI
Sbjct: 61 NIHTG-EYADARDADIVVITAGVPRKPGESRLDLINRNTKILESIVKPVVASGFNGCFVI 119
Query: 456 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+SNPVDILT +T ++SG P+HRVIG+GT+LD+AR+
Sbjct: 120 SSNPVDILTSMTQRLSGFPRHRVIGTGTSLDTARL 154
>UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila
melanogaster|Rep: AT22132p - Drosophila melanogaster
(Fruit fly)
Length = 361
Score = 129 bits (311), Expect = 6e-29
Identities = 59/164 (35%), Positives = 102/164 (62%), Gaps = 1/164 (0%)
Frame = +3
Query: 69 KLFQPVHEKVDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQ 248
K +P+ E SK+++VG GQVG A + +L +N+T N+ ++D+ + K E +D Q
Sbjct: 35 KSMRPMKEFKRPRISKISVVGAGQVGTAISAMLLLRNLTKNLVILDINYELAKAEALDFQ 94
Query: 249 HGSAFMRNAKIQSSTDYSITAGSKICVVTAGVR-QREGESRLDLVQRNTDVLKQIIPQLI 425
H SAF+ +A++ D + + S + ++TAG R + SRL +Q+ ++LK+ +P+L+
Sbjct: 95 HASAFLSDARVVPCGDSTNSKDSDVVIITAGARPSGKDRSRLAAMQKTVEILKKAVPKLV 154
Query: 426 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+ SP+ +I SNP D++TY +I+ LPKHR +G +LD+ R
Sbjct: 155 ELSPNATFIIISNPADVMTYAVQRITNLPKHRCFTTGCHLDTVR 198
>UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibacter
ruber DSM 13855|Rep: L-lactate dehydrogenase -
Salinibacter ruber (strain DSM 13855)
Length = 316
Score = 128 bits (309), Expect = 1e-28
Identities = 62/148 (41%), Positives = 100/148 (67%), Gaps = 1/148 (0%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTD 296
V IVG G VG AAA++M Q++ + I L+D + +GE MDL HG + ++ +
Sbjct: 7 VGIVGTGNVGTAAAYAMFNQSLASEILLLDQDTRRAEGEAMDLMHGQQLVGGITCRA-VE 65
Query: 297 YSITAGSKICVVTAGVRQRE-GESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
Y+ + ++I V++AG Q+ E+RL L+QRN ++ ++II QL K++P+ ILV+A+NPVD
Sbjct: 66 YAALSNAQIIVLSAGASQQSPDETRLGLLQRNAEIFREIIIQLDKHAPNAILVVATNPVD 125
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+LTY+ ++S P R++G+GT LD+AR
Sbjct: 126 VLTYICQELSSRPNRRILGTGTLLDTAR 153
>UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 319
Score = 128 bits (309), Expect = 1e-28
Identities = 58/150 (38%), Positives = 97/150 (64%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
SK+++VG G VG + A++ L + ++L D+ DK++ E+ DL HG+ F A +
Sbjct: 11 SKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGTQFTP-ASVMGG 69
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
D TA S + +TAG RQ+ G++RLDL N ++L+ ++PQL++ SP+ + V+ +NP
Sbjct: 70 ADVHDTADSDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQSPNALFVLVTNPC 129
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D+LT V + +GLP +RV +GT LD++R+
Sbjct: 130 DVLTVVAQEATGLPANRVFSTGTMLDTSRL 159
>UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2;
Desulfovibrio vulgaris subsp. vulgaris|Rep: L-lactate
dehydrogenase - Desulfovibrio vulgaris (strain
Hildenborough / ATCC 29579 / NCIMB8303)
Length = 309
Score = 128 bits (309), Expect = 1e-28
Identities = 62/149 (41%), Positives = 99/149 (66%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+++ ++GVG VGMA A++ + + N+I L+D A + +GE MDL A + +I+S
Sbjct: 2 NRIAVIGVGNVGMAFAYAAAIKRLANDIVLIDANAARAEGESMDLADAMALVGPVQIRSG 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
Y G++I VVTAG +Q G+SRLDLV+ N + + I+ +++Y+ D + ++A+NPV
Sbjct: 62 -GYEQCEGARIVVVTAGAKQMPGQSRLDLVRVNAGITRDILTAVMQYADDPLYIMATNPV 120
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D+LT+V ++G+ RVIGSGT LDSAR
Sbjct: 121 DVLTHVARTVTGVAPGRVIGSGTVLDSAR 149
>UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1;
Corynebacterium jeikeium K411|Rep: L-lactate
dehydrogenase - Corynebacterium jeikeium (strain K411)
Length = 326
Score = 127 bits (306), Expect = 2e-28
Identities = 60/150 (40%), Positives = 96/150 (64%), Gaps = 1/150 (0%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQS 287
SK+ ++G G VG+A A++++ Q +T+++A++D+ K G + DL H + N ++
Sbjct: 16 SKIVLIGAGDVGIAYAYTLVNQGLTDHLAIIDLDERKTWGHVQDLNHAVPWSHHNTRVTV 75
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
T + +C+ AG Q+ GE+RLDLV +NT + K I+ ++ + + I ++ASNP
Sbjct: 76 GTYEDCRDAAMVCIC-AGAAQKPGETRLDLVAKNTAIFKTIVGDVMSHGFNGIFLVASNP 134
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
VDIL+Y TWK SG+ RVIGSGT LD+AR
Sbjct: 135 VDILSYATWKFSGMDSSRVIGSGTILDTAR 164
>UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2;
Ruminococcus|Rep: Putative uncharacterized protein -
Ruminococcus torques ATCC 27756
Length = 316
Score = 125 bits (302), Expect = 7e-28
Identities = 61/149 (40%), Positives = 95/149 (63%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K ++G G VG A++++ + + + + L+D K +GE MD+ HG F I +
Sbjct: 6 KAAVIGCGFVGSTIAYTLMQKGLFSEMVLLDANKAKAEGEAMDISHGLPFTHAMDIYAG- 64
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+Y A + + ++TAG Q+ GE+RLDLVQ+N +++ II ++ + + + IL+I SNPVD
Sbjct: 65 EYEDIADASVVIITAGANQKPGETRLDLVQKNAAIMRSIIKEIKRVNCEGILLIVSNPVD 124
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
ILT V + SG PK RVIGSGT LD+AR+
Sbjct: 125 ILTEVALRESGFPKERVIGSGTVLDTARL 153
>UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate
dehydrogenase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to lactate dehydrogenase - Nasonia vitripennis
Length = 352
Score = 123 bits (297), Expect = 3e-27
Identities = 55/150 (36%), Positives = 97/150 (64%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+K+ IVG G VG+A A +L + + + L+D + + E D+ + F+ + KI++S
Sbjct: 38 TKIVIVGSGPVGVAVAVGLLFKRLAAELILMDENPEMARAEAEDIAAAAVFLGSPKIRAS 97
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
TDYS + +CV+ AG +QR+ ++Q+N +LK+++P L KY+P+++L++ S PV
Sbjct: 98 TDYSEARDATLCVIAAGRQQRDEADAEAVLQQNALLLKELVPSLTKYAPNSVLLVVSEPV 157
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D+L+++ K+SG P RV+G GT LD+ R+
Sbjct: 158 DVLSHLAMKLSGFPSQRVLGLGTLLDNCRL 187
>UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4;
Lactobacillus|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri
Length = 312
Score = 123 bits (297), Expect = 3e-27
Identities = 66/150 (44%), Positives = 93/150 (62%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSML-TQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
KV ++G G VG + AFS L + N + + LVD K G+ DL + KI +
Sbjct: 8 KVVLIGDGAVGSSFAFSFLQSTNEVDELVLVDRTKSKAVGDAADLADITPLTNPVKIYAG 67
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
T Y A + + V+TAG+ ++ GE+RLDLV +NT +LK II ++K + VI+SNPV
Sbjct: 68 T-YEDAADADVVVITAGIPRKPGETRLDLVNKNTTILKSIIKPIVKSGFTGVFVISSNPV 126
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DILT + +ISG PK RVIG+GT+LDS R+
Sbjct: 127 DILTTIAQRISGFPKERVIGTGTSLDSMRL 156
>UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula
stellata E-37|Rep: L-lactate dehydrogenase - Sagittula
stellata E-37
Length = 300
Score = 123 bits (297), Expect = 3e-27
Identities = 61/139 (43%), Positives = 92/139 (66%)
Frame = +3
Query: 141 VGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTDYSITAGSK 320
VG AAAF+ + + V + I LVD+ + + E D+ H F +A+I + Y +G+
Sbjct: 2 VGSAAAFACIMRGVASEIVLVDLDTARAQAEAEDIAHAVPFSVSARIVAG-GYDDLSGAD 60
Query: 321 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 500
+ ++ GV Q+ GESRL+L+ RN +V + ++ + + +PD IL+IASNPVDI+T+VT +
Sbjct: 61 VVILACGVSQKPGESRLELLSRNAEVFRAVVGDVTRAAPDAILLIASNPVDIMTHVTQAL 120
Query: 501 SGLPKHRVIGSGTNLDSAR 557
SGLP RVIGSGT LD+AR
Sbjct: 121 SGLPAGRVIGSGTILDTAR 139
>UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13;
Firmicutes|Rep: L-lactate dehydrogenase 3 - Bacillus
anthracis
Length = 316
Score = 120 bits (290), Expect = 2e-26
Identities = 55/149 (36%), Positives = 92/149 (61%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ I+G G VG + A+S++ Q + + L+D+ ++ GE MDL H F +
Sbjct: 7 KIAIIGTGLVGSSCAYSIVNQGICEELLLIDINHERAVGEAMDLSHCINFTNTRTKVYAG 66
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
Y I ++TAG + G+SRLD + + +++ ++ +++ D I ++ASNPVD
Sbjct: 67 SYEDCKDMDIVIITAGPAPKPGQSRLDTLGASAKIMESVVGGVMESGFDGIFLLASNPVD 126
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
I+TY WK+SGLP++RVIG+GT+LDS+R+
Sbjct: 127 IITYQVWKLSGLPRNRVIGTGTSLDSSRL 155
>UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;
Clostridium phytofermentans ISDg|Rep: L-lactate
dehydrogenase precursor - Clostridium phytofermentans
ISDg
Length = 325
Score = 120 bits (288), Expect = 3e-26
Identities = 56/150 (37%), Positives = 95/150 (63%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
SKV +VG G VG + AFS++TQ+V + + L+D+ K GE+MDL H ++ + +
Sbjct: 8 SKVIVVGAGLVGTSTAFSLITQSVCDEVMLIDINRAKAHGEVMDLCHSIEYLNRNVLVTE 67
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DY+ + I V+TAG + G+SRLD + + D++ I+ ++K + I ++ +NPV
Sbjct: 68 GDYTDCKDADIVVITAGPPPKPGQSRLDTLGLSADIVSTIVEPVMKSGFNGIFLVVTNPV 127
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D + +++SGLPK +V+G+GT +DSAR+
Sbjct: 128 DSIAQYVYQLSGLPKQQVLGTGTAIDSARL 157
>UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Lactate/malate
dehydrogenase - Thermosinus carboxydivorans Nor1
Length = 303
Score = 118 bits (285), Expect = 8e-26
Identities = 56/148 (37%), Positives = 96/148 (64%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ IVG G+VG A ++ + + + + I +VD DK GE +D+ AF A+I+
Sbjct: 2 KIAIVGSGKVGAAIGYTAMLKGLAHEIVMVDAARDKAHGEALDMLQCLAFAPPARIRHG- 60
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+ + TAG+ I V+TAG+ ++ E R+ L+ RN ++ ++ Q + YSP+ I+ + +NP+D
Sbjct: 61 EMADTAGADIVVITAGIPRKADEPRVLLLSRNAALIADLVRQAVHYSPNCIIFMVTNPLD 120
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
++T + +++SGLP +RVIG GT LD+AR
Sbjct: 121 VMTQLAYQVSGLPANRVIGMGTVLDTAR 148
>UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7;
Bacteria|Rep: L-lactate dehydrogenase - Deinococcus
radiodurans
Length = 304
Score = 118 bits (284), Expect = 1e-25
Identities = 56/148 (37%), Positives = 95/148 (64%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV +VG G VG AAF+++ + + + LVD D+ + E D+ H + ++
Sbjct: 2 KVGVVGTGFVGSTAAFALVLRGSCSELVLVDRDEDRAQAEAEDIAHAAPVSHGTRVWHG- 60
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+S A +++ ++TAG Q+ GESRLDL+++N D+ ++++PQ+ + +PD +L++ SNPVD
Sbjct: 61 GHSELADAQVVILTAGANQKPGESRLDLLEKNADIFRELVPQITRAAPDAVLLVTSNPVD 120
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+LT + +++ P VIGSGT LDSAR
Sbjct: 121 LLTDLATQLA--PGQPVIGSGTVLDSAR 146
>UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizopus
oryzae|Rep: L-lactate dehydrogenase A - Rhizopus oryzae
(Rhizopus delemar)
Length = 320
Score = 118 bits (283), Expect = 1e-25
Identities = 59/150 (39%), Positives = 95/150 (63%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
SKV IVG G VG + A++++ +N+ I +VD+ D ++ +++DL ++ S
Sbjct: 5 SKVAIVGAGAVGASTAYALMFKNICTEIIIVDVNPDIVQAQVLDLADAASISHTPIRAGS 64
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+ + A I V+TAG +QREGE R L++RN VL+ II + PD ++++ +NPV
Sbjct: 65 AEEAGQAD--IVVITAGAKQREGEPRTKLIERNFRVLQSIIGGMQPIRPDAVILVVANPV 122
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DILT++ +SGLP ++VIGSGT LD+ R+
Sbjct: 123 DILTHIAKTLSGLPPNQVIGSGTYLDTTRL 152
>UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2;
Phaeosphaeria nodorum|Rep: L-lactate dehydrogenase -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 326
Score = 117 bits (282), Expect = 2e-25
Identities = 58/156 (37%), Positives = 97/156 (62%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTD 296
+ ++G G VG A++++ Q++ + LVD L G++ DL ++ R+ K++S T
Sbjct: 10 IAVIGCGDVGATLAYTLILQSICTEVLLVDPKTSLLDGQVRDLSDATS--RSTKVRSGT- 66
Query: 297 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 476
+ + I V+TAG +Q+ GESRL L+ RN ++L I + S T+L++ +NPVDI
Sbjct: 67 HQEAGQADIVVITAGAKQKTGESRLSLLTRNLNILSSIFDSMKPISAHTVLLLVANPVDI 126
Query: 477 LTYVTWKISGLPKHRVIGSGTNLDSARVPLPAXGQA 584
L Y +SGLP+++V+G+GT+LDSAR+ G+A
Sbjct: 127 LVYFARMMSGLPENQVLGTGTSLDSARLRGVLAGKA 162
>UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2;
Bacteria|Rep: L-lactate dehydrogenase - Treponema
denticola
Length = 315
Score = 116 bits (279), Expect = 4e-25
Identities = 64/156 (41%), Positives = 92/156 (58%), Gaps = 2/156 (1%)
Frame = +3
Query: 96 VDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA 275
+DE KVT+VG G VG A+++ + IA+ DM + +G+ +DL G F+
Sbjct: 1 MDEKKRKVTVVGAGAVGSTFAYALAQSGYADEIAITDMNKNFAEGQALDLVQGLPFLPQV 60
Query: 276 KIQSS--TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 449
I + TDY A S I VVTAG +Q+ GE+R+DL++RN ++ I + + ++
Sbjct: 61 DIHAGDKTDY---ADSDIVVVTAGAKQQSGETRIDLLKRNASIITGIAKDIAESGCSGVM 117
Query: 450 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+I SNPVDILT K SG + RVIGSGT LD+AR
Sbjct: 118 LIVSNPVDILTRAALKASGWERGRVIGSGTVLDTAR 153
>UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14;
Thermoprotei|Rep: Malate dehydrogenase - Pyrobaculum
aerophilum
Length = 309
Score = 115 bits (277), Expect = 7e-25
Identities = 54/149 (36%), Positives = 94/149 (63%), Gaps = 1/149 (0%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSST 293
+TI+G G+VG AAA M + N I L+D++ +GE +D+ H S+ + + + S
Sbjct: 2 ITIIGSGRVGTAAAVIMGLMKLDNKILLIDIVKGLPQGEALDMNHMSSILGLDVEYVGSN 61
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+Y GS + +VTAG+ ++ G +R L++ N ++ +I ++ KY+PD+I+++ +NP+D
Sbjct: 62 EYKDIEGSDLIIVTAGLPRKPGMTREQLLEANAKIVAEIGREIKKYAPDSIVILTTNPLD 121
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+TYV WK +G P+ RVIG LD+ R+
Sbjct: 122 AMTYVMWKATGFPRERVIGFSGVLDAGRL 150
>UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
beijerinckii NCIMB 8052|Rep: L-lactate dehydrogenase -
Clostridium beijerinckii NCIMB 8052
Length = 316
Score = 115 bits (276), Expect = 1e-24
Identities = 55/150 (36%), Positives = 90/150 (60%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
SKV IVG G VG A AF M+ +V +++ L+D+ +K E DLQH + +
Sbjct: 6 SKVVIVGTGSVGAAVAFDMVMNHVCDDLILIDINKEKSWAEATDLQHSLGYSGSKMRVKD 65
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+Y + I V+ A + G++RLD++++ ++ I+P ++K I+V+ +NPV
Sbjct: 66 GEYEECNDADIVVIAAALPYITGQTRLDMLEKAAGIMNNIVPNIMKSGFSGIIVVITNPV 125
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D+++Y K+SGLP +VIG+GT LDSAR+
Sbjct: 126 DVMSYYVHKLSGLPASKVIGTGTALDSARL 155
>UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep: Malate/lactate
dehydrogenase - Leptospirillum sp. Group II UBA
Length = 320
Score = 114 bits (275), Expect = 1e-24
Identities = 52/149 (34%), Positives = 94/149 (63%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMD-LQHGSAFMRNAKIQSS 290
KV+IVG G VG A + +N ++ ++D+ +G+ +D L+ G + +I S
Sbjct: 8 KVSIVGAGNVGATTA-QKIVENGLADVVILDVREGMAQGKALDILESGPLLGFDTRIVGS 66
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+Y GS + VVTAG ++ G SR DL+ +N D++ ++ ++ K++PD+++++ +NP+
Sbjct: 67 GNYETIEGSSVVVVTAGFSRKPGMSREDLLHKNGDIMIEVAEKIRKHAPDSVVIMVTNPM 126
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D++ Y+ WK++G P+ RVIG G LDS+R
Sbjct: 127 DLMAYILWKVTGFPRERVIGMGGALDSSR 155
>UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular
organisms|Rep: Malate dehydrogenase - Dehalococcoides
sp. (strain CBDB1)
Length = 307
Score = 114 bits (274), Expect = 2e-24
Identities = 53/150 (35%), Positives = 93/150 (62%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDL-QHGSAFMRNAKIQSS 290
K++++G G VG A ++ ++ + + ++D++ +G+ +D+ Q S I S
Sbjct: 3 KISVIGAGNVGATLAQRLIEKDFAD-VVMLDVVEGIPQGKALDISQSASVLGFRHTITGS 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DY+ TAGS+I V+TAG+ ++ G +R +L+ N ++ ++ +KYSP+ LV+ SNPV
Sbjct: 62 NDYAQTAGSEIVVITAGIARKPGMTREELLAINQKIMTDVVSNCLKYSPEATLVVVSNPV 121
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D +TY+ WK+SGLP+ RV+G LD R+
Sbjct: 122 DTMTYLAWKLSGLPRKRVVGLSGVLDGGRL 151
>UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28;
Bacteroidetes|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 313
Score = 113 bits (273), Expect = 2e-24
Identities = 55/151 (36%), Positives = 91/151 (60%), Gaps = 2/151 (1%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR--NAKIQ 284
SKVT+VG G VG A + V + + ++D+ +G+ MD+ + + +
Sbjct: 2 SKVTVVGAGNVGATCANVLAFNEVADEVVMLDVKEGVSEGKAMDMMQTAQLLGFDTTIVG 61
Query: 285 SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
+ DY+ TA S + V+T+G+ ++ G +R +L+ N ++K + L+KYSP+ I+V+ SN
Sbjct: 62 CTNDYAQTANSDVVVITSGIPRKPGMTREELIGVNAGIVKSVAENLLKYSPNAIIVVISN 121
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
P+D +TY+ K GLPK+RVIG G LDS+R
Sbjct: 122 PMDTMTYLALKSLGLPKNRVIGMGGALDSSR 152
>UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=15; Euteleostomi|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Homo sapiens (Human)
Length = 471
Score = 113 bits (271), Expect = 4e-24
Identities = 57/154 (37%), Positives = 96/154 (62%)
Frame = +3
Query: 99 DETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAK 278
++T +K+T+VG G++G+A ++ + + + + L+D+ ++ KG MDL+
Sbjct: 179 NKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDL-SEGTKGATMDLE----IFNLPN 233
Query: 279 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 458
++ S D S +A SK+ + T +S LD+VQ N D+ + ++P L YS ++L++A
Sbjct: 234 VEISKDLSASAHSKVVIFTVN-SLGSSQSYLDVVQSNVDMFRALVPALGHYSQHSVLLVA 292
Query: 459 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
S PV+I+TYVTWK+S P +RVIG G NLDS R+
Sbjct: 293 SQPVEIMTYVTWKLSTFPANRVIGIGCNLDSQRL 326
>UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD binding
domain protein; n=2; Campylobacter|Rep: Lactate/malate
dehydrogenase, NAD binding domain protein -
Campylobacter curvus 525.92
Length = 297
Score = 111 bits (268), Expect = 9e-24
Identities = 52/149 (34%), Positives = 90/149 (60%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDL-QHGSAFMRNAKIQSS 290
K++++G G VG + A+++ + V + IALVD+ D + + +D+ Q G F
Sbjct: 2 KISVIGAGNVGASIAYALAMRGVCDEIALVDIFGDVARAKAIDIAQAGCVFCGCLSTAGG 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
D+++ S I VVTAG ++EG++R DL+ +N V+KQ + K++P+ I++I +NP+
Sbjct: 62 DDFALIEASDIVVVTAGSPRKEGQTREDLLLKNAQVVKQTAQNIAKFAPNAIVIIVTNPL 121
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D++ + + SG + RVIG LDSAR
Sbjct: 122 DVMVWTVLRYSGFDRSRVIGMAGELDSAR 150
>UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 237
Score = 111 bits (266), Expect = 2e-23
Identities = 55/150 (36%), Positives = 93/150 (62%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
S++ IVGVGQVG AAA++++ ++ + + LVD A G++ DL + R+ S
Sbjct: 8 SRIAIVGVGQVGAAAAYALVLGSIADELLLVDTRAAWRDGQVRDLSDAAYASRSKTRVYS 67
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
Y + I V+TAG + G++ +D + RNT +++ II ++ + DT+L+I +NPV
Sbjct: 68 ATYREASQCDIVVITAGSKYLYGQTSMDYLYRNTSIVRSIINEMKPFRSDTVLLIVANPV 127
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D++T + ++S LP +V+GSGT LDS R+
Sbjct: 128 DLMTSLAKELSNLPSAQVLGSGTFLDSIRL 157
>UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=2;
Desulfitobacterium hafniense|Rep: Malate dehydrogenase,
NAD-dependent - Desulfitobacterium hafniense (strain
DCB-2)
Length = 320
Score = 109 bits (262), Expect = 5e-23
Identities = 54/152 (35%), Positives = 94/152 (61%), Gaps = 3/152 (1%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADK--LKGEMMDLQHGSAFMRNA-KI 281
+K++++G G G AF ML +I L+D A++ KG+ +D+ R++ ++
Sbjct: 2 AKISVIGSGFTGTTTAF-MLAMKGLGDIVLLDTQANENPTKGKALDIMEAGPLTRSSVRV 60
Query: 282 QSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 461
++DY T S + V+TAG+ ++ G SR +L N ++ ++ Q++++SP++ L+I S
Sbjct: 61 TGTSDYQDTLDSDVVVITAGIARKPGMSRNELCDINAGIVTHVVRQVVQHSPNSTLIILS 120
Query: 462 NPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
NPVDI+TYV +K SG ++R+IG LDSAR
Sbjct: 121 NPVDIMTYVAFKESGFKRNRIIGQSGVLDSAR 152
>UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3;
Bifidobacterium longum|Rep: L-lactate dehydrogenase 1 -
Bifidobacterium longum
Length = 316
Score = 109 bits (261), Expect = 6e-23
Identities = 54/151 (35%), Positives = 91/151 (60%), Gaps = 1/151 (0%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQS 287
+KV IVG GQVG AAF ++T + N + L+D A K GE DL GS F R+ K+++
Sbjct: 7 NKVVIVGTGQVGATAAFGIVTHGLCNELVLIDCSAAKALGEARDLDDGSEFQDRHVKVRA 66
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
DY+ + I V+T G + +R+ + ++ +++ ++ D ++V+ SNP
Sbjct: 67 G-DYADCKDADIVVITVGRKPPANSNRMAELGFTVGLVGEVVDNVMASGFDGVIVMVSNP 125
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
VD++ + WK SGLP+ +V+G+GT LD++R+
Sbjct: 126 VDVMAWYAWKRSGLPRTQVLGTGTALDTSRL 156
>UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacter
hominis ATCC BAA-381|Rep: Malate dehydrogenase -
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 /
NCTC 13146 /CH001A)
Length = 297
Score = 108 bits (260), Expect = 9e-23
Identities = 51/151 (33%), Positives = 87/151 (57%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVT-NNIALVDMMADKLKGEMMDLQH-GSAFMRNAKIQS 287
K++I+G G +G +L ++ + IAL+D+ D K +DL H S + + +I
Sbjct: 2 KISIIGAGNIGSNIVSQLLCKDFEISQIALIDIFGDLAKARALDLSHLASVYNKKTEISG 61
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
S+D ++ S I V+TAG ++ G+SR DL+ N ++ + KY+P+ I+++ +NP
Sbjct: 62 SSDETLLKNSDIVVITAGKTRQAGQSRADLLNDNAKIISSCAKNVAKYAPEAIIILITNP 121
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
VD L +V +K SG K ++I LDSAR+
Sbjct: 122 VDTLAFVAYKASGFKKEKIIAMAGELDSARL 152
>UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2;
Euryarchaeota|Rep: Malate dehydrogenase - Methanopyrus
kandleri
Length = 317
Score = 108 bits (260), Expect = 9e-23
Identities = 56/153 (36%), Positives = 95/153 (62%), Gaps = 4/153 (2%)
Frame = +3
Query: 111 SKVTIVGV-GQVGMAAAFSMLTQNVTNNIALV--DMMADKLKGEMMDLQHG-SAFMRNAK 278
SKV ++G G+VG AA + + N + L+ DKL+G D+ +A ++A+
Sbjct: 2 SKVAVIGATGRVGSTAAARLALLDCVNEVTLIARPKSVDKLRGLRRDILDSLAAAQKDAE 61
Query: 279 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 458
I + + + V+TAG+ ++ G++RLDL + N ++K+ + + + +P+ I+++
Sbjct: 62 ITIGCERDDYVDADVIVMTAGIPRKPGQTRLDLTKDNAAIIKKYLEGVAEENPEAIVLVV 121
Query: 459 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+NPVD+LTYV K+SGLPK+RVIG GT+LDS R
Sbjct: 122 TNPVDVLTYVALKVSGLPKNRVIGLGTHLDSMR 154
>UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18;
Bacteria|Rep: L-lactate dehydrogenase 2 - Listeria
innocua
Length = 311
Score = 108 bits (260), Expect = 9e-23
Identities = 55/150 (36%), Positives = 89/150 (59%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV I+G G VG AAA + + Q + LVD+ ++++G DL +AFM S
Sbjct: 5 KVMIIGAGNVGSAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMSGKMDISVR 64
Query: 294 DYSITAGSKICVVTAGVRQ-REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+ S A I V+T +EG++RLD ++ + ++ I+P+++K I +IA+NP
Sbjct: 65 EASDCADVDIAVITVTAGPLKEGQTRLDELRSTSRIVASIVPEMMKGGFKGIFLIATNPC 124
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DI+TY WK+SGLP+ +V+G+G LD+ R+
Sbjct: 125 DIITYQVWKLSGLPREQVLGTGVWLDTTRL 154
>UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1;
Staphylococcus haemolyticus JCSC1435|Rep: L-lactate
dehydrogenase - Staphylococcus haemolyticus (strain
JCSC1435)
Length = 318
Score = 108 bits (259), Expect = 1e-22
Identities = 51/148 (34%), Positives = 89/148 (60%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ ++G G VG A A +++ + + + +A++D+ DK K ++ DL H + F N
Sbjct: 5 KIVLIGSGYVGSAFAHAIVAKGLVDEMAIIDIDEDKAKADVWDLNHATPFGDNFVNVHVG 64
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
Y + I V+ A + +GE+RL L++ N D+ +I +++ D V+ SNPVD
Sbjct: 65 QYEDFKDADIVVICASAKLAKGETRLKLLEDNVDIFVPMIQRIVDSGFDGYFVLPSNPVD 124
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
I++YV ++S PK+++IGSGT+LD+AR
Sbjct: 125 IMSYVVKRVSNFPKNKIIGSGTSLDTAR 152
>UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Malate dehydrogenase -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 311
Score = 107 bits (256), Expect = 3e-22
Identities = 51/150 (34%), Positives = 90/150 (60%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA-FMRNAKIQSS 290
K+TIVG G+VG A A ++ + + L+D +G +D+Q + F +A++ S
Sbjct: 5 KITIVGAGRVGEATAQFLVKNELCRELVLLDAQEGVAQGAALDIQQSAPLFDFDARVTGS 64
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
T+Y + A S + V+TAG ++ G SR D++ N ++ I+ +++++P ++++I +NPV
Sbjct: 65 TNYELIADSDLVVITAGKPRKPGMSRSDVLDSNLPIITDIMNNVMRFAPQSLVMIVTNPV 124
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D+LTY W+ G + RV G LDSAR+
Sbjct: 125 DVLTYHAWRHCGWDRARVFGQAGVLDSARM 154
>UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2;
Gammaproteobacteria|Rep: Lactate dehydrogenase -
Reinekea sp. MED297
Length = 319
Score = 105 bits (253), Expect = 6e-22
Identities = 50/151 (33%), Positives = 88/151 (58%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA--FMRNAKIQS 287
K+ ++G G VG+ L + + L+D K +GEMMD H ++ F +N ++++
Sbjct: 2 KIGVIGAGAVGVGVCHYTLAFGSCSELVLIDQQIGKAEGEMMDFGHANSLTFSKNIRLRA 61
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
DYS+ + I V+TAG + +EG++R DL + N+ + I ++ +P+ IL++ +NP
Sbjct: 62 GDDYSLLTDADIVVITAGAQIKEGQTRDDLAEINSRITVDIAQKIETVAPNAILLVVTNP 121
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DI TY + +G P RVI +G +D+AR+
Sbjct: 122 CDIATYFITQNTGFPADRVISAGCIIDTARL 152
>UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4;
Pezizomycotina|Rep: L-lactate dehydrogenase -
Aspergillus clavatus
Length = 312
Score = 105 bits (252), Expect = 8e-22
Identities = 58/151 (38%), Positives = 92/151 (60%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA--KIQS 287
++ IVGVGQVG AAA +++ +V + LVD+ ++ +L S A +I++
Sbjct: 9 RIAIVGVGQVGGAAANALILGSVARELLLVDVKIPLRNAQVQELSDVSNMSGGAETRIRA 68
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
T Y I V+TAG + GE+ + + RN ++++IIP + + PDTIL++ SNP
Sbjct: 69 GT-YEEAGQCDIVVITAGSKYSVGETSVQHMYRNMGIVQKIIPAMRPFRPDTILLVVSNP 127
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
VD+LT V ++SGLP +V+GSGT L+S R+
Sbjct: 128 VDLLTTVAQQLSGLPPTQVLGSGTLLESVRL 158
>UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=1; Apis
mellifera|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 368
Score = 105 bits (251), Expect = 1e-21
Identities = 49/149 (32%), Positives = 91/149 (61%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV+IVGVG++G+A A ++L + + + + L+D A+K E D+QH F+ + ++
Sbjct: 50 KVSIVGVGKIGIACAIAILMRRMASEVCLIDHDANKASAEAEDIQHVGFFLGCPLVTGTS 109
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+ S S + ++ GE++ V+ N V K+IIP + +++ ++L+I + P D
Sbjct: 110 EISTVKESAVVIICTP-ETPPGENQN--VKHNLKVFKKIIPAIARFAAKSVLLIVTRPAD 166
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+++Y+ WK+SG P +RV+G GT +D AR+
Sbjct: 167 VMSYIAWKLSGFPSNRVLGIGTLIDCARL 195
>UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4;
Bacteria|Rep: L-lactate dehydrogenase - Blastopirellula
marina DSM 3645
Length = 313
Score = 104 bits (250), Expect = 1e-21
Identities = 62/151 (41%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQ-VGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
KV+I+G G VG AAF++ + IAL+D+ AD G +DL HG+ + + I S
Sbjct: 2 KVSIIGGGGLVGSCAAFALQCGGIAREIALLDLNADLAGGHALDLLHGAPSVADQVITSG 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIK--YSPDTILVIASN 464
I IC+ TAG+R++ ESRLDL+ RN D+ I+ + D I + SN
Sbjct: 62 GYEHIPDSDVICI-TAGLRRKPDESRLDLINRNVDLFLSILDSVKSAGVKKDAICFVVSN 120
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
PVDILTY+ + LP RVIG GT LD+ R
Sbjct: 121 PVDILTYLAAQRLNLPTSRVIGLGTQLDTIR 151
>UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: Malate/L-lactate
dehydrogenase - Cenarchaeum symbiosum
Length = 302
Score = 104 bits (250), Expect = 1e-21
Identities = 51/148 (34%), Positives = 92/148 (62%), Gaps = 1/148 (0%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSST 293
+TI+G G+VG AA + + + I L+D++ +GE MD+ H A + +++ S
Sbjct: 2 ITIIGAGKVGGDAAMFCALRRLDSEILLLDIVEGLPQGEAMDINHMLAEQGIDTEVRGSN 61
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
DYS GS I VV AG ++ G +R+DL++ N ++K ++ ++ +++ D++++ +NP+D
Sbjct: 62 DYSDMEGSDIVVVVAGAGRKPGMTRMDLLKINAGIVKGVVEKVKEHAKDSMIIPVTNPLD 121
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+TY+ +K SG K+RV G G LD +R
Sbjct: 122 PITYIAYKTSGFEKNRVFGMGGMLDLSR 149
>UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 312
Score = 103 bits (247), Expect = 3e-21
Identities = 51/149 (34%), Positives = 85/149 (57%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ I+G G VG A+++ Q + + I LVD K K MD+ +F ++ I
Sbjct: 6 KIVIIGAGHVGSHCAYALAIQGICDEIVLVDKDRTKAKSHSMDIADSVSFFNSSVIVRCG 65
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
DYS + I V++AGV + G++RLD++ + + ++ I+ L K I++ +NP D
Sbjct: 66 DYSDCKDADIIVISAGVPRLPGQTRLDVLDGSVECVRDIVSNLNKIEIKGIIITITNPAD 125
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
I+ K +GLPK+RV +GT+LD+AR+
Sbjct: 126 IIADFVRKATGLPKNRVFSTGTSLDTARM 154
>UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1;
Clostridium acetobutylicum|Rep: L-lactate dehydrogenase
2 - Clostridium acetobutylicum
Length = 320
Score = 103 bits (246), Expect = 4e-21
Identities = 54/154 (35%), Positives = 91/154 (59%), Gaps = 4/154 (2%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR--NAKIQ 284
+K+ +VG G VG A S+L+ N+ + + ++D+ +K KGE +D H ++F N K++
Sbjct: 6 NKLVVVGAGMVGSAVLNSVLSLNLLSEVVIIDINDNKAKGEALDASHTTSFAYSPNVKVR 65
Query: 285 SSTDYSITAGSKICVVTAGVRQREGES--RLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 458
+ +Y A ++I V+TAG + + RL L N V I+ + KY+ D I+++
Sbjct: 66 AG-NYEDCADAQIIVITAGPSLKPDDKLDRLVLADTNVKVTDSIMKNICKYTKDAIIIVV 124
Query: 459 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+NPVDI TY PK+++IG+GT LD+AR+
Sbjct: 125 TNPVDIATYYCQNNFDYPKNKIIGTGTLLDTARM 158
>UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4;
Thermoplasmatales|Rep: Malate dehydrogenase -
Thermoplasma volcanium
Length = 325
Score = 102 bits (245), Expect = 6e-21
Identities = 52/154 (33%), Positives = 90/154 (58%), Gaps = 6/154 (3%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAF------MRNA 275
K++++G G VG A + T+ + ++ L D++ +G+ +D+Q G+ +
Sbjct: 5 KISVIGAGNVGATVAQFLATKEL-GDVYLFDVVDGIPEGKALDIQEGAPHWGYDLDVVGF 63
Query: 276 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 455
S++Y GS + VVTAG+ ++ G SR DL +N +++ + + KYSPD+I+V+
Sbjct: 64 STSDSSNYKNMEGSDVIVVTAGMARKPGMSREDLFDKNVEIIADVSKNIKKYSPDSIIVV 123
Query: 456 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
SNP DI+ Y KISG+ R++G G +LDS+R
Sbjct: 124 VSNPADIMAYALQKISGVDPQRIMGLGGSLDSSR 157
>UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular
organisms|Rep: Malate dehydrogenase - Gloeobacter
violaceus
Length = 325
Score = 102 bits (245), Expect = 6e-21
Identities = 53/150 (35%), Positives = 90/150 (60%), Gaps = 1/150 (0%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQS 287
SKV+I+G G VG A A ++ NV + + L+D++ + +G +DL +I
Sbjct: 9 SKVSILGAGNVGSALAQRLIQGNVAD-VVLLDIVEGRPQGITLDLLEACGVEGHTCRITG 67
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
+ DY+ TAGS + VV AG ++ G SR DL+ NT ++ ++ + + +SP+ +V+ +NP
Sbjct: 68 TNDYAQTAGSDVLVVAAGFARQPGMSRDDLLLTNTRIVFEVTQKAVAHSPEATVVVVTNP 127
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+D +++V W+ SGL RV+G LD+AR
Sbjct: 128 LDAMSHVAWRASGLVPERVMGMAGVLDAAR 157
>UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6;
Mollicutes|Rep: L-lactate dehydrogenase - Mesoplasma
florum (Acholeplasma florum)
Length = 317
Score = 102 bits (245), Expect = 6e-21
Identities = 53/153 (34%), Positives = 87/153 (56%)
Frame = +3
Query: 102 ETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKI 281
+T +KV +VG G VGM+ +S + Q + L+D+ +G +D+Q A +
Sbjct: 3 KTSNKVVLVGTGAVGMSFIYSAVNQGLAEEYVLIDVNTKAAEGNAIDIQDTMAVLDKPFT 62
Query: 282 QSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 461
+ Y + + V+TAG QR GE+RL+L+ N+ ++K I + + + VIAS
Sbjct: 63 IKAGTYEDCKDADLIVITAGRPQRPGETRLELIADNSRIMKGIAEAIKASGFNGVTVIAS 122
Query: 462 NPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
NP D+LT V +++G +H V+G+GT LDSAR+
Sbjct: 123 NPCDVLTTVYQQVTGYDEHSVVGAGTTLDSARL 155
>UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
pulmonis|Rep: L-lactate dehydrogenase - Mycoplasma
pulmonis
Length = 315
Score = 102 bits (244), Expect = 7e-21
Identities = 50/150 (33%), Positives = 89/150 (59%), Gaps = 2/150 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAF--MRNAKIQS 287
KV ++G G VG+ ++M+T+ + L+D+ + KG MD+ A +KI++
Sbjct: 3 KVVLIGTGNVGVTVVYTMITKGIDAEYVLIDINTEFAKGHAMDMSDAIALNSTTGSKIRT 62
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
T Y+ G+ + +V AG Q++GE+RL+++ N+ ++K I ++ K + ++ SNP
Sbjct: 63 GT-YADAKGADLLIVAAGRPQKQGETRLEMIADNSKIMKDIALEIKKSGFNGFTIVISNP 121
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
VDIL V K++ PK +V+ SGT LD++R
Sbjct: 122 VDILATVFQKVTNFPKEKVMSSGTFLDTSR 151
>UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=23; Tetrapoda|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Mus musculus (Mouse)
Length = 471
Score = 101 bits (243), Expect = 1e-20
Identities = 54/150 (36%), Positives = 87/150 (58%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+K+T+VG G +G+A ++ + + + + L+D+ +D + MDL ++ S
Sbjct: 183 NKITVVGSGDLGIACTLAISAKGIADKLLLLDL-SDGMSQGTMDLD----IFNLPNVEIS 237
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
D S +A SK+ + TA ES L VQ N D+ + ++P L YS +L++AS PV
Sbjct: 238 KDLSASAHSKVVIFTAN-SLGGSESYLHAVQSNVDMFRALVPALGHYSQHAVLLVASQPV 296
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+I++YVTWK+S P RV+G G NLDS R+
Sbjct: 297 EIMSYVTWKLSTFPATRVVGIGCNLDSQRL 326
>UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3;
Fusobacterium nucleatum|Rep: L-lactate dehydrogenase -
Fusobacterium nucleatum subsp. nucleatum
Length = 318
Score = 101 bits (243), Expect = 1e-20
Identities = 57/150 (38%), Positives = 88/150 (58%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV IVG+G VG A SML Q V + + L+D++ +K K +D +F+ + I
Sbjct: 6 KVGIVGIGHVGSHCALSMLLQGVCDEMVLMDIIPEKAKAHAIDCMDTISFLPHRAI--IR 63
Query: 294 DYSITAGSKICVVTAGVRQ-REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
D I SK+ V+ V + E RL+ ++ + + +K +P ++K + I V +NPV
Sbjct: 64 DGGIQELSKMDVIVISVGSLTKNEQRLEELKGSLEAIKSFVPDVVKAGFNGIFVTITNPV 123
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DI+TY ++SG PK+RVIG+GT LDSAR+
Sbjct: 124 DIVTYFVRELSGFPKNRVIGTGTGLDSARL 153
>UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: L-lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 312
Score = 101 bits (242), Expect = 1e-20
Identities = 48/148 (32%), Positives = 92/148 (62%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTD 296
+ ++G G +G + AF+ LT V ++ ++D+ +++G++ DL + I +++
Sbjct: 7 IILIGDGAIGSSYAFNCLTTGVGQSLGIIDVNEKRVQGDVEDLSDALPYTSQKNIYAAS- 65
Query: 297 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 476
Y + I V+TAG+ Q+ G++RL L+ N ++K+I ++ + +++ASNPVD+
Sbjct: 66 YEDCKYADIIVITAGIAQKPGQTRLQLLAINAKIMKEITHNIMASGFNGFILVASNPVDV 125
Query: 477 LTYVTWKISGLPKHRVIGSGTNLDSARV 560
L + + SGLP+++V+GSGT LDSAR+
Sbjct: 126 LAELVLQESGLPRNQVLGSGTALDSARL 153
>UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2;
Planctomycetaceae|Rep: L-lactate/malate dehydrogenase -
Rhodopirellula baltica
Length = 304
Score = 101 bits (241), Expect = 2e-20
Identities = 56/150 (37%), Positives = 92/150 (61%), Gaps = 2/150 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQSS 290
K+T+VG G+VG A AF++ + + + L++ +K +G+ +DL H +A + N KI SS
Sbjct: 2 KITLVGTGRVGSAIAFALTINPLASELLLLNRSREKAEGDALDLTHAAALVDSNIKI-SS 60
Query: 291 TDYSITAGSKICVVTAGVRQR-EGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
+ + + S + + TA V R ++RL++ N +L+ +P L K SP+ I+V+ SNP
Sbjct: 61 GEIADSKDSDVIIFTASVPFRYPNQTRLEMGIDNMPILRDWMPGLAKASPNAIVVMVSNP 120
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
VD L Y T +++G RVIG+GT +DS R
Sbjct: 121 VDALAYETIRLTGFDPKRVIGTGTLVDSIR 150
>UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=1;
Sulfurovum sp. NBC37-1|Rep: Malate dehydrogenase,
NAD-dependent - Sulfurovum sp. (strain NBC37-1)
Length = 320
Score = 101 bits (241), Expect = 2e-20
Identities = 49/150 (32%), Positives = 88/150 (58%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDL-QHGSAFMRNAKIQSS 290
KVT++G G G AF + +++ L D KG+ +D+ Q +A ++ ++++
Sbjct: 6 KVTVIGTGNFGSTVAFILAMNGSCHHVMLRGRNYDVAKGKALDMSQAANAARQHTIVKAA 65
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
GS + ++TAG + G SR DL+ +N D++K ++ +Y+PD I+++ SNP+
Sbjct: 66 KGPEDMEGSDVVIITAGAPRTPGMSRDDLLFKNADIVKCYSREIKEYAPDAIVIVVSNPL 125
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D++TYV K +G P+ RV+G LD+AR+
Sbjct: 126 DVMTYVALKETGFPRQRVLGMAGILDAARM 155
>UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacter
fetus subsp. fetus 82-40|Rep: Malate dehydrogenase -
Campylobacter fetus subsp. fetus (strain 82-40)
Length = 306
Score = 101 bits (241), Expect = 2e-20
Identities = 48/149 (32%), Positives = 85/149 (57%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSS 290
K+ I+G G VG + A ++++ V + L+D+ + + MDL +A + + I
Sbjct: 2 KIAIIGAGNVGASCASLLISRKVCKKVTLIDINKNLAIAKAMDLAQMAAVLNLDIDIFGG 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+Y + I V+TAG +++G+SR DL N ++ + K++P +I+++ +NP+
Sbjct: 62 DNYELLKDFDIVVITAGFARKDGQSRDDLAMMNAKIVSHSSKMVSKFAPKSIIIVVTNPL 121
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
DI+ YV +K SG +H+VIG LDSAR
Sbjct: 122 DIMVYVAFKESGFARHKVIGMAGELDSAR 150
>UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
difficile (strain 630)
Length = 322
Score = 100 bits (239), Expect = 3e-20
Identities = 54/155 (34%), Positives = 90/155 (58%), Gaps = 6/155 (3%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQSS 290
K++IVG G VG FS++TQ V + + ++D+ K K + +DL +++ I+
Sbjct: 7 KISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSKAQALDLADAVSYLPHKVHIEKG 66
Query: 291 TDYSITAGSKICVVTA-----GVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 455
T +S S I V++ G +R+ +RLDL++ ++K I+ ++ D I V+
Sbjct: 67 T-FSDCKDSDIVVISVADSSEGPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFDGIFVV 125
Query: 456 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
SNPVD++T W+ SG PK++VIG+GT LDS R+
Sbjct: 126 ISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRL 160
>UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 304
Score = 100 bits (239), Expect = 3e-20
Identities = 48/148 (32%), Positives = 89/148 (60%), Gaps = 1/148 (0%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSST 293
+TI+G G+VG AA + + + I L+D+ +GE MD+ H + + +++ S
Sbjct: 2 ITIIGSGKVGGDAALFSALKRLDDQILLLDVAEGLPQGEAMDINHMLSEQGIDVEVKGSN 61
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
++ GS I VV AG ++ G +R+DL++ N ++K ++ + KY+ D++++ +NP+D
Sbjct: 62 NFEDMKGSNIVVVVAGSGRKPGMTRMDLLKINASIVKSVVENVKKYADDSMIIPVTNPLD 121
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+ Y+T+K+SG + RV G G LD +R
Sbjct: 122 PMAYITYKVSGFDRSRVFGMGGMLDLSR 149
>UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:
Lactate dehydrogenase - Vibrio parahaemolyticus
Length = 317
Score = 99.5 bits (237), Expect = 5e-20
Identities = 47/151 (31%), Positives = 89/151 (58%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA--FMRNAKIQS 287
K+ ++G G VG+ +LT + + L+D ++ +GE+ D +H +A F +N +I
Sbjct: 2 KIGVIGAGAVGVGVCNYLLTLGSVSELVLLDQNLERAEGEVFDFRHTAALTFSKNTRIIP 61
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
S DY G+ I V+TAG + ++G++RLD+ + N + +I ++ + +P +L++ SNP
Sbjct: 62 SDDYLDLLGADIVVITAGAQIQQGQTRLDIAEINAKIGVEIARKIERVAPKAVLIVVSNP 121
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DI+ + +G ++VI SG +D+AR+
Sbjct: 122 CDIVAHFITTNTGFEPNKVISSGCVIDTARL 152
>UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate
dehydrogenases; n=2; Nostoc punctiforme PCC 73102|Rep:
COG0039: Malate/lactate dehydrogenases - Nostoc
punctiforme PCC 73102
Length = 317
Score = 98.7 bits (235), Expect = 9e-20
Identities = 51/151 (33%), Positives = 88/151 (58%), Gaps = 1/151 (0%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
SKV I+G G VG A +++ + L D K +G++ D++ ++ +I S
Sbjct: 6 SKVGIIGAGNVGADVANALVLLGRCVRVVLFDRTLSKAEGQVWDIEDSIPLLKEMEIIPS 65
Query: 291 TDYSITAGSKICV-VTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
Y A S I + VTAGV+ + G++RLD + N ++++ I +L + +P++I++I SNP
Sbjct: 66 NQYEDLADSDIIIIVTAGVQPKLGQTRLDTLSDNAEIIRSTIKELDRVAPNSIVIIISNP 125
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
VD+LT + S ++ + GSGT LD+AR+
Sbjct: 126 VDVLTRIAQATSTRAENLIFGSGTVLDTARL 156
>UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10444.1 - Gibberella zeae PH-1
Length = 309
Score = 96.7 bits (230), Expect = 4e-19
Identities = 48/150 (32%), Positives = 88/150 (58%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
S+V IVGVG+VG A A+++ ++ + + LVD+ ++ DL + ++ S
Sbjct: 5 SRVAIVGVGEVGGAVAYNLTLNSMASELLLVDLDPSARNAQIEDLSDVTYSTNSSTRVRS 64
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
Y A + V+TA + G++ +D RNT +L+ ++ + + DT+L+I ++PV
Sbjct: 65 ATYHEAAQCDLVVITAASKHMLGQTTIDYTSRNTSMLRGVMEAMKPFRADTVLLIVADPV 124
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D+LT + ++SGLP+ +V G+GT LD+ R+
Sbjct: 125 DLLTSLAKQMSGLPESQVFGTGTALDTYRL 154
>UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7;
Halobacteriaceae|Rep: Malate dehydrogenase - Haloarcula
marismortui (Halobacterium marismortui)
Length = 304
Score = 96.3 bits (229), Expect = 5e-19
Identities = 51/152 (33%), Positives = 88/152 (57%), Gaps = 3/152 (1%)
Frame = +3
Query: 111 SKVTIVGV-GQVGMAAAFSMLTQNVTNNIALVDM--MADKLKGEMMDLQHGSAFMRNAKI 281
+KV++VG G VG AA +++ +++ + + VD+ D G+ D HG A+ N ++
Sbjct: 2 TKVSVVGAAGTVGAAAGYNIALRDIADEVVFVDIPDKEDDTVGQAADTNHGIAYDSNTRV 61
Query: 282 QSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 461
+ Y TAGS + V+TAG+ ++ G++R+DL N +++ I L +++ D I + S
Sbjct: 62 RQG-GYEDTAGSDVVVITAGIPRQPGQTRIDLAGDNAPIMEDIQSSLDEHNDDYISLTTS 120
Query: 462 NPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
NPVD+L ++ + +VIG G LDSAR
Sbjct: 121 NPVDLLNRHLYEAGDRSREQVIGFGGRLDSAR 152
>UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|Rep:
Malate dehydrogenase 1 - Aquifex aeolicus
Length = 335
Score = 95.9 bits (228), Expect = 6e-19
Identities = 55/161 (34%), Positives = 94/161 (58%), Gaps = 14/161 (8%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDM-------MADKLKGEMMDLQHGSAFMR-N 272
V ++G G VG A +L +N+ N + + D+ + + +KG+ +D++ A M +
Sbjct: 7 VAVIGAGNVGEHVASLILLKNLAN-VKMFDLPRKTEEKVFEPVKGKALDMKQMLAAMDID 65
Query: 273 AKIQSST------DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYS 434
A+++ T Y GS I V+TAG +R G SR DL++ N ++ I ++ +Y+
Sbjct: 66 ARVEGYTVTPEGEGYEPLEGSDIVVITAGFPRRPGMSREDLLEANIRIISVIADRIKRYA 125
Query: 435 PDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
PD I+++ +NPVD++TYV +K+ PK+RV+G LDSAR
Sbjct: 126 PDAIVIVVTNPVDVMTYVAYKLLNFPKNRVMGMAGVLDSAR 166
>UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein
OJA1212_C06.24; n=1; Oryza sativa (japonica
cultivar-group)|Rep: Putative uncharacterized protein
OJA1212_C06.24 - Oryza sativa subsp. japonica (Rice)
Length = 255
Score = 95.5 bits (227), Expect = 9e-19
Identities = 56/120 (46%), Positives = 69/120 (57%)
Frame = -3
Query: 550 ESKLVPDPITRCLGSPLIFHVTYVRISTGLLAITNIVSGLYFISCGIICLSTSVFLCTRS 371
ES+LVP+P+TR G+P FH TYV STGL I++ SG S G I +++ F C+R
Sbjct: 56 ESRLVPEPMTRLAGNPDSFHATYVSTSTGLETISSSASGECSASAGTIFRNSATFRCSRF 115
Query: 370 RRDSPSRCRTPAVTTQIFEPAVIE*SVLDWILAFLMNADPCCRSIISPFNLSAIMSTRAM 191
RR SP R PAVT EP V SV + NA CCRS ISP +LS ST A+
Sbjct: 116 RRLSPGIWRAPAVTMARSEPRVTARSVSETRRTRGRNAAACCRSSISPRSLSGTASTSAI 175
>UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
genitalium
Length = 312
Score = 94.7 bits (225), Expect = 1e-18
Identities = 51/150 (34%), Positives = 88/150 (58%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ IVG G VG + ++ +T+ + + ++D+ G + DLQ S+ N +
Sbjct: 5 KIAIVGSGAVGTSFLYAAMTRALGSEYMIIDINEKAKVGNVFDLQDASSSCPNFGKVVAG 64
Query: 294 DYSITAGSKICVVTAGVRQREG-ESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+YS ++AG Q++G E+RL L++ N +++K I ++ K + + +IASNPV
Sbjct: 65 EYSQLKDYDFIFISAGRPQKQGGETRLQLLEGNVEIMKSIAKEIKKSGFNGVTLIASNPV 124
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
DI++Y K++G ++VIGSGT LDSAR+
Sbjct: 125 DIMSYTYLKVTGFEPNKVIGSGTLLDSARL 154
>UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3;
Lactococcus lactis|Rep: L-lactate dehydrogenase 3 -
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Length = 323
Score = 94.3 bits (224), Expect = 2e-18
Identities = 51/153 (33%), Positives = 87/153 (56%), Gaps = 4/153 (2%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA-KIQSS 290
KV IVG G VG A +++ ++ + IA+++ K +DL H ++ A K +
Sbjct: 7 KVVIVGAGAVGSTYAHNLVVDDLADEIAIINTNKSKASANSLDLLHALPYLNAAPKNIYA 66
Query: 291 TDYSITAGSKICVVTAGVRQR---EGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 461
DYS + + I V++A + RL L++ ++++ I + + D I ++AS
Sbjct: 67 ADYSDVSDADIVVLSANAPSATFGKNPDRLQLLENKVEMIRDITRKTMDAGFDGIFLVAS 126
Query: 462 NPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
NPVD+L V ++SGLPKHRVIG+GT L+++R+
Sbjct: 127 NPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRM 159
>UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
mobile|Rep: L-lactate dehydrogenase - Mycoplasma mobile
Length = 318
Score = 93.9 bits (223), Expect = 3e-18
Identities = 49/156 (31%), Positives = 87/156 (55%), Gaps = 1/156 (0%)
Frame = +3
Query: 96 VDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLK-GEMMDLQHGSAFMRN 272
+D+ +V +VG G VG++ +S + + + ++D+ DKL G +D + SA +
Sbjct: 1 MDKKIKRVAMVGAGLVGVSVLYSCMNRGLAEQYGIIDIN-DKLSVGHSLDFEDASAANNH 59
Query: 273 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 452
+YS + V+TAG Q+ GE+RL++V N ++ I + K + +
Sbjct: 60 NFSVGKIEYSDLKDYDVVVITAGRPQKPGETRLEMVADNAKIMSNIAKNIKKSGFKGVSI 119
Query: 453 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+ +NPVD++T++ +G K+RVI SGT+LDSAR+
Sbjct: 120 VVANPVDVMTFIYQHETGFDKNRVISSGTSLDSARL 155
>UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like
protein; n=1; Methylibium petroleiphilum PM1|Rep:
Malate/lactate dehydrogenases-like protein - Methylibium
petroleiphilum (strain PM1)
Length = 432
Score = 92.3 bits (219), Expect = 8e-18
Identities = 47/149 (31%), Positives = 84/149 (56%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSS 290
K +VG G VG A + ++ + +ALVD++ G +D+ HG+ + ++ S
Sbjct: 125 KAGVVGAGHVGAMTALRLAESDLFSEVALVDVVPGLAAGLALDMWHGAGLYGFSTRLSGS 184
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
D AG++ V+TAG ++ G SR DL N +++ + + ++P++ LVI SNP+
Sbjct: 185 DDLVALAGAEYIVITAGKPRQPGMSRTDLTVVNAEIMTSVCRGIRTHAPNSTLVIVSNPL 244
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+ +T++ + +G P+ RV+G LDSAR
Sbjct: 245 EEMTHLAAQQTGFPEERVLGMAGVLDSAR 273
>UniRef50_O26290 Cluster: Malate dehydrogenase; n=2;
Methanobacteriaceae|Rep: Malate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 325
Score = 92.3 bits (219), Expect = 8e-18
Identities = 50/153 (32%), Positives = 86/153 (56%), Gaps = 4/153 (2%)
Frame = +3
Query: 114 KVTIVG-VGQVGMAAAFSMLTQNVTNNIALVDMMA--DKLKGEMMDLQHGSAFMR-NAKI 281
KV+I+G G+VG A A + + + L+ ++ GE++D+ A + K+
Sbjct: 2 KVSIIGSTGRVGRATALCLAEEEAVKTLHLISRKESLEQNLGEVLDMSDALAAKGVSVKL 61
Query: 282 QSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 461
++S D GS+I V+TAGV + R DL +N ++ Q+ +++PD+I+++ +
Sbjct: 62 ENSADIENVYGSRIVVITAGVPRTADMDRDDLAFKNGRIVADYARQIARFAPDSIILVVT 121
Query: 462 NPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
NPVD++TYV + SG RV G G +LDS R+
Sbjct: 122 NPVDVMTYVALRYSGFHPSRVFGLGNHLDSLRL 154
>UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 330
Score = 91.5 bits (217), Expect = 1e-17
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 7/159 (4%)
Frame = +3
Query: 102 ETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAK 278
E KV ++G G G A + ++ + L D++ + +G +D+ K
Sbjct: 10 ERRGKVAVIGAGFYGSTTAQRLAEYDIFETVVLTDIIEGRPEGLALDINQSRPIEGFETK 69
Query: 279 IQSSTD------YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPD 440
+ T Y + A + I ++TAGV ++ G SR+DL++ N +++ + + KY+P
Sbjct: 70 VIGKTTSPDGAGYEVIADASIVIITAGVPRKPGMSRMDLLETNARIVRGVAENIAKYAPS 129
Query: 441 TILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
++++ SNP+D +T +T ++G PK+RV+G LD+AR
Sbjct: 130 AVVIVVSNPLDEMTALTQLVTGFPKNRVMGQAGMLDTAR 168
>UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1;
Aspergillus niger|Rep: Catalytic activity: precursor -
Aspergillus niger
Length = 307
Score = 91.5 bits (217), Expect = 1e-17
Identities = 44/149 (29%), Positives = 88/149 (59%), Gaps = 1/149 (0%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA-KIQSST 293
+ ++G+G VG + A S++ + + + LVD+ + ++ DL + + KI+++T
Sbjct: 4 IALIGLGSVGASTALSLIHRRIQGTLLLVDIKSSLRDAQVRDLADAALVYGSVTKIEAAT 63
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+ + + + ++TAGV GE+ L + +LK I+ ++ ++P+ I+++ +NPVD
Sbjct: 64 -HQEASQADVVIITAGVNYTPGETTLQHLYHKFSILKSILNEMRPFNPNAIILVVANPVD 122
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
LT + I+GLP+ +VIG GT +DS R+
Sbjct: 123 TLTTLAQDIAGLPRKQVIGVGTCIDSLRL 151
>UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Rep:
Malate dehydrogenase - Brucella melitensis
Length = 320
Score = 89.8 bits (213), Expect = 4e-17
Identities = 47/150 (31%), Positives = 84/150 (56%), Gaps = 1/150 (0%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQS 287
+K+ ++G G +G A + + ++ L D+ +G+ +D+ S +AK
Sbjct: 4 NKIALIGSGMIGGTLAHLAGLKEL-GDVVLFDIAEGTPQGKGLDIAESSPVDGFDAKFTG 62
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
+ DY+ G+ + +VTAGV ++ G SR DL+ N V++Q+ + KY+P+ ++ +NP
Sbjct: 63 ANDYAAIEGADVVIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPEAFVICITNP 122
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+D + + K SGLP H+V+G LDSAR
Sbjct: 123 LDAMVWALQKFSGLPAHKVVGMAGVLDSAR 152
>UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular
organisms|Rep: Malate dehydrogenase - Silicibacter
pomeroyi
Length = 320
Score = 89.0 bits (211), Expect = 7e-17
Identities = 46/149 (30%), Positives = 86/149 (57%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDL-QHGSAFMRNAKIQSS 290
K+ ++G GQ+G A + + + ++ L D+ +G+ +D+ + G + +AK++ +
Sbjct: 5 KIALIGAGQIGGTLAHLVALKEL-GDVVLFDIAEGTPEGKALDIAESGPSEGFDAKLKGT 63
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
Y+ AG+ +C+VTAGV ++ G SR DL+ N V+K + + +PD ++ +NP+
Sbjct: 64 QSYADIAGADVCIVTAGVPRKPGMSRDDLLGINLKVMKSVGEGIRDNAPDAFVICITNPL 123
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D + + + SGLP ++V G LDSAR
Sbjct: 124 DAMVWALQQFSGLPANKVCGMAGVLDSAR 152
>UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12;
Campylobacter|Rep: Probable malate dehydrogenase -
Campylobacter jejuni
Length = 300
Score = 89.0 bits (211), Expect = 7e-17
Identities = 43/149 (28%), Positives = 83/149 (55%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSS 290
K+T++G G VG + A++++ + + N I LVD+ D L + ++L A + N + +
Sbjct: 2 KITVIGAGNVGSSVAYALILREIANEIVLVDINEDLLYAKELELTQSIAALNLNIDLLCT 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DY+ T S I + +AG +++G+SR +L+Q NT ++ ++ ++ D + +I +NPV
Sbjct: 62 KDYTHTKNSDIVLFSAGFARKDGQSREELLQLNTSIMLDCAKKIKDFTEDPLFIILTNPV 121
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D L ++ ++I LD+AR
Sbjct: 122 DFLLNTLYESGIFSSKKIIAMAGVLDNAR 150
>UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4;
Epsilonproteobacteria|Rep: Malate dehydrogenase -
Wolinella succinogenes
Length = 314
Score = 88.6 bits (210), Expect = 1e-16
Identities = 48/147 (32%), Positives = 80/147 (54%), Gaps = 1/147 (0%)
Frame = +3
Query: 123 IVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHG-SAFMRNAKIQSSTDY 299
I+G G VG AF + TQ + I + D+ D +G +D+ H SA + ++ + +
Sbjct: 3 IIGAGHVGSTVAFILATQGICQEIIIKDLNLDTARGIALDMGHAASATKTHTIVRVANEP 62
Query: 300 SITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDIL 479
S G + V AG ++ G SR DL+ N V++ ++ ++ Y +++LV+ SNP+D +
Sbjct: 63 SDLRGCDVVVFCAGSPRQPGMSRDDLLLANAKVIRTVLSEVKPYIQESVLVMVSNPLDAM 122
Query: 480 TYVTWKISGLPKHRVIGSGTNLDSARV 560
Y K SGL +V+G LDSAR+
Sbjct: 123 VYTAIKESGLSPLQVLGMAGILDSARM 149
>UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex
aeolicus|Rep: Malate dehydrogenase 2 - Aquifex aeolicus
Length = 334
Score = 88.6 bits (210), Expect = 1e-16
Identities = 57/156 (36%), Positives = 86/156 (55%), Gaps = 8/156 (5%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKL---KGEMMDLQHGSAFMR---NA 275
K++++G G+VG A+ +LT ++ L L K + +DL+ + M N
Sbjct: 15 KISVIGAGKVGENVAY-LLTILGLGDVYLFARYKKGLEPAKAKALDLKQMAVLMDIDINV 73
Query: 276 KIQS--STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 449
K S + GS I V+TAG+ +REG SR DL+ N +LK+ + +Y+ D+I+
Sbjct: 74 KGISYDKEGFEELKGSDIVVITAGIPRREGMSREDLLYENLKILKKFTDAIKEYAKDSII 133
Query: 450 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
++ SNPVD LTY T K++G RVIG LDSAR
Sbjct: 134 IVVSNPVDTLTYATIKLTGFEPRRVIGMAGVLDSAR 169
>UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2;
Toxoplasma gondii|Rep: Mitochondrial
malate-dehydrogenase - Toxoplasma gondii
Length = 470
Score = 88.2 bits (209), Expect = 1e-16
Identities = 43/150 (28%), Positives = 84/150 (56%), Gaps = 1/150 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSS 290
K+ ++G G +G A + + ++ + D++ D +G+ +DL + + + + S
Sbjct: 159 KIGLIGGGNIGATLALLSAVKEL-GDVVMFDVVQDLPQGKCLDLYQLTPISGVDVRFEGS 217
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DYS+ + + +VTAGV ++ G SR DL+ N ++ Q+ + +Y P+ ++ +NP+
Sbjct: 218 NDYSVLKDADVIIVTAGVPRKPGMSRDDLLAINAKIMGQVGEAIKQYCPNAFVICITNPL 277
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D++ Y+ + GLP H+V G LDSAR+
Sbjct: 278 DVMVYILREKCGLPPHKVCGMAGVLDSARL 307
>UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;
Candidatus Methanoregula boonei 6A8|Rep: L-lactate
dehydrogenase precursor - Methanoregula boonei (strain
6A8)
Length = 332
Score = 88.2 bits (209), Expect = 1e-16
Identities = 55/154 (35%), Positives = 83/154 (53%), Gaps = 4/154 (2%)
Frame = +3
Query: 111 SKVTIVGV-GQVGMAAAFSMLTQNVTNNIALVDMMADK--LKGEMMDLQHGSAFM-RNAK 278
SKVTI+G G VG AA+++ + I L + LKG D A N +
Sbjct: 2 SKVTIIGATGNVGTFAAYAVSVDPHVHEILLYGREGREAFLKGLAQDFADSFAARGTNIR 61
Query: 279 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 458
+ +T AGS I V+TAG + G++RLDL N ++ + + +PDT +++
Sbjct: 62 VTWTTSLKDVAGSDIVVITAGTPRGPGQNRLDLALGNARIIAPMARTIGTIAPDTKIIMV 121
Query: 459 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+NPVD++T V K SGL ++V G GT+LDS R+
Sbjct: 122 TNPVDVMTCVALKYSGLKPNQVFGLGTHLDSMRL 155
>UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasma
hyopneumoniae|Rep: L-lactate dehydrogenase - Mycoplasma
hyopneumoniae
Length = 315
Score = 88.2 bits (209), Expect = 1e-16
Identities = 47/149 (31%), Positives = 80/149 (53%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ ++G G VG + ++ + Q + + ++D+ D G D + SA + S
Sbjct: 5 KIALIGAGNVGNSFLYAAMNQGLASEYGIIDINPDFADGNAFDFEDASASLPFPISVSRY 64
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+Y + V+TAG Q+ GE+RL+LV N ++++I ++ + I +I +NPVD
Sbjct: 65 EYKDLKDADFIVITAGRPQKPGETRLELVADNIRIIREIALKVKESGFSGISIIVANPVD 124
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
I+T SG +VIGSGT LD+AR+
Sbjct: 125 IITRAYRDASGFSDQKVIGSGTVLDTARL 153
>UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep:
Lin1775 protein - Listeria innocua
Length = 302
Score = 87.8 bits (208), Expect = 2e-16
Identities = 44/149 (29%), Positives = 83/149 (55%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV I+G G VG AFS++TQ + + I ++D + K + E ++L+ ++ R+ ++
Sbjct: 4 KVGIIGAGHVGSDVAFSLVTQGICDEIVIIDKIEAKAESEALELRDMASMTRSYTTITAN 63
Query: 294 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+ + + I V+ G E R++ + + + +I+P+++ I V +NP D
Sbjct: 64 SWEALSDADIIVMAVGPETLLREDRMEELVETSRSVTEIVPKILATGFKGIFVNITNPCD 123
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
++T + KISG RV G+GT+LD+AR+
Sbjct: 124 VITMLIQKISGFDHSRVFGTGTSLDTARM 152
>UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1;
Blastopirellula marina DSM 3645|Rep: L-lactate/malate
dehydrogenase - Blastopirellula marina DSM 3645
Length = 308
Score = 87.8 bits (208), Expect = 2e-16
Identities = 46/151 (30%), Positives = 86/151 (56%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA-KIQSS 290
KV+++G+G+VG A A +++ + + + + LV + + E DL H + ++ ++++
Sbjct: 2 KVSLIGLGKVGSAVAHAIVLKGLADELVLVSRRTEMARSEADDLNHAAGLEEHSVEVRAG 61
Query: 291 TDYSITAGSKICVVTAGVRQREGE-SRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
D TAGS + + + + + R + N + L++ IP L SP I V+ +NP
Sbjct: 62 GDVD-TAGSDVILYCDAAQSKTSDVDRYCAARGNLERLRERIPILAAASPQAICVMVTNP 120
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
VD++T+ ++SG P+ RV G GT LD+AR+
Sbjct: 121 VDVMTWFALQLSGFPQERVFGVGTLLDTARL 151
>UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3;
Methanomicrobiales|Rep: L-lactate dehydrogenase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 319
Score = 87.4 bits (207), Expect = 2e-16
Identities = 56/156 (35%), Positives = 85/156 (54%), Gaps = 6/156 (3%)
Frame = +3
Query: 111 SKVTIVGV-GQVGMAAAFSMLTQNVTNNIALV-----DMMADKLKGEMMDLQHGSAFMRN 272
+KVTI+G GQVG A ++ + L + D L +MMD +A N
Sbjct: 2 AKVTIIGATGQVGSYVAHAVSQFPHVQEMCLYGRPGNEQYLDGLAHDMMD--SFAARGTN 59
Query: 273 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 452
++ T GS I V+T+GV ++ ++RLDL N ++K Q+ + +P+ IL+
Sbjct: 60 TRVTFGTTPKELRGSDIIVLTSGVPRKATQTRLDLALENARIVKVFAEQVGRMAPEAILL 119
Query: 453 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+ +NPVDI+T V K SG+ HRV G GT+LDS R+
Sbjct: 120 VVTNPVDIMTTVALKYSGMMPHRVFGLGTHLDSMRL 155
>UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;
Ignicoccus hospitalis KIN4/I|Rep: malate dehydrogenase
(NAD) - Ignicoccus hospitalis KIN4/I
Length = 311
Score = 87.0 bits (206), Expect = 3e-16
Identities = 48/149 (32%), Positives = 83/149 (55%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA-FMRNAKIQSS 290
KV ++G G+VG A++M + LVD + KG M D++H +A F R+ ++++
Sbjct: 7 KVAVIGTGRVGATFAYTMAIVPGVARMVLVDAVPGLSKGVMEDIKHAAAVFRRSIQVEAY 66
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
D S + V+TAG ++ SR DL + N +++ I +L +P ++ +NPV
Sbjct: 67 DDVSKVENADAIVITAGKPRKADMSRRDLAKVNAQIIRDIGDKLRDRNPGAFYMVITNPV 126
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D++T + + G K VIG+GT+LD+ R
Sbjct: 127 DVMTMILSDVIG-NKGTVIGTGTSLDTYR 154
>UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 303
Score = 86.6 bits (205), Expect = 4e-16
Identities = 50/149 (33%), Positives = 86/149 (57%), Gaps = 2/149 (1%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAK--IQSS 290
++IVG G+VG + AF + N +++ LV+ +K GE +D+ SA N+K I+ +
Sbjct: 5 ISIVGTGRVGASIAF-LCVSNGLDDVLLVNTTKEKAIGESLDV--ASAIPANSKFSIRGT 61
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DYS GS I ++ A V + R + + ++K I ++ KY P I+++ SNP+
Sbjct: 62 DDYSELIGSDIVIIAASVGIYT-KHRAENIDHQVAMIKNIAKKIKKYCPSAIVLLVSNPL 120
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D+LTY K +G + +VIG ++LD++R
Sbjct: 121 DVLTYFFQKTTGFSRFKVIGIASSLDTSR 149
>UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococcus
saprophyticus subsp. saprophyticus ATCC 15305|Rep:
Lactate dehydrogenase - Staphylococcus saprophyticus
subsp. saprophyticus (strain ATCC 15305 /DSM 20229)
Length = 310
Score = 85.4 bits (202), Expect = 9e-16
Identities = 46/151 (30%), Positives = 80/151 (52%), Gaps = 2/151 (1%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA--KIQ 284
SK+ I+G+G+VG + N+ + I L+D AD GE +D H + A KI+
Sbjct: 2 SKLGIIGLGKVGTQVLTDVQQLNLFSEIILIDDRADVASGEALDHIHSQGLINTAHIKIR 61
Query: 285 SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
S +T I + + + R L Q N D++K I+ Q+ + + + ++++ SN
Sbjct: 62 SGVYQDLTDADFIVIAASEATDKNNGDRTLLAQGNHDIIKGIMSQIAEVTQEAVVILISN 121
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
PVD + Y +I P H++IG+GT L+++R
Sbjct: 122 PVDSMVYFANQID-YPAHKIIGTGTALETSR 151
>UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17;
Apicomplexa|Rep: L-lactate dehydrogenase - Plasmodium
falciparum (isolate CDC / Honduras)
Length = 316
Score = 85.4 bits (202), Expect = 9e-16
Identities = 45/156 (28%), Positives = 87/156 (55%), Gaps = 6/156 (3%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQS 287
+K+ +VG G +G A +++ Q ++ L D++ + G+ +D H + N K+
Sbjct: 5 AKIVLVGSGMIGGVMA-TLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSG 63
Query: 288 STDYSITAGSKICVVTAGVRQREGES-----RLDLVQRNTDVLKQIIPQLIKYSPDTILV 452
S Y AG+ + +VTAG + G+S R DL+ N ++ +I + K P+ ++
Sbjct: 64 SNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFII 123
Query: 453 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+ +NPVD++ + + SG+PK+++IG G LD++R+
Sbjct: 124 VVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRL 159
>UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomonas
ruminantium|Rep: L-lactate dehydrogenase - Selenomonas
ruminantium
Length = 318
Score = 84.6 bits (200), Expect = 2e-15
Identities = 42/151 (27%), Positives = 81/151 (53%), Gaps = 3/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ ++G VG A A + + + L+D+ DK GE D H ++ + + I+
Sbjct: 6 KIVVIGASNVGSAVANKIADFQLATEVVLIDLNEDKAWGEAKDSSHATSCIYSTNIKFHL 65
Query: 294 -DYSITAGSKICVVTAGVRQREGES--RLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
DY + I V+TAG R GE+ RL L N ++ ++ +++K + + ++++ +N
Sbjct: 66 GDYEDCKDANIIVITAGPSIRPGETPDRLKLAGTNAKIMSSVMGEIVKRTKEAMIIMITN 125
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
P+D+ TYV P++ ++G+GT L++ R
Sbjct: 126 PLDVATYVVSTQFDYPRNLILGTGTMLETYR 156
>UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene
encodes predicted malate dehydrogenase; n=8;
Cryptosporidium|Rep: Lactate dehydrogenase, adjacent
gene encodes predicted malate dehydrogenase -
Cryptosporidium parvum Iowa II
Length = 337
Score = 84.2 bits (199), Expect = 2e-15
Identities = 42/149 (28%), Positives = 82/149 (55%), Gaps = 1/149 (0%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA-FMRNAKIQSS 290
K+ ++G GQ+G A+ + N+ + + L D+ +G+ +D+ H F +K+ +
Sbjct: 22 KIAVIGSGQIGGNIAYIVGKDNLAD-VVLFDIAEGIPQGKALDITHSMVMFGSTSKVIGT 80
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
DY+ +GS + ++TA + R + R +L+ N +L + + KY P+ ++ +NP+
Sbjct: 81 NDYADISGSDVVIITASIPGRPKDDRSELLFGNARILDSVAEGVKKYCPNAFVICITNPL 140
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
D++ K+SGLP ++V G LDS+R
Sbjct: 141 DVMVSHFQKVSGLPHNKVCGMAGVLDSSR 169
>UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=3;
Lactobacillales|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 304
Score = 83.8 bits (198), Expect = 3e-15
Identities = 43/151 (28%), Positives = 84/151 (55%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQSS 290
K+ +VG+G VG+ A ++ Q + + I LVD +KL E +D + ++ + + ++ +
Sbjct: 3 KIGVVGIGHVGVTVAHIIIAQGLADEIVLVDKNPEKLASEELDFRDAASLLDHHVEVHAG 62
Query: 291 TDYSITAGSKICVVTAGVRQ-REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
T +T + + + G R ++ NT ++Q+ L + + +L++ SNP
Sbjct: 63 TVTDLTDAEVVISALGHIELIKPGGDRFTELKANTPEVQQVGSDLKQAGFNGVLIVISNP 122
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
VD++T + K +GLP ++V G+GT LD+AR+
Sbjct: 123 VDVITGIYQKATGLPANQVFGTGTYLDTARL 153
>UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5;
Methanococcus|Rep: Malate dehydrogenase - Methanococcus
maripaludis
Length = 314
Score = 81.4 bits (192), Expect = 1e-14
Identities = 52/153 (33%), Positives = 83/153 (54%), Gaps = 6/153 (3%)
Frame = +3
Query: 117 VTIVGV-GQVGMAAAFSMLTQNVTNNIALVDMMA--DKLKGEMMDLQHGSAFM---RNAK 278
V+I+G G++G + + ++ NI L+ + +KLKG MDL A +
Sbjct: 3 VSIIGASGKIGSVLSLLLAKESHIKNINLIARSSSINKLKGLKMDLYDAMAAAGQDTDID 62
Query: 279 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 458
I D S TA S I ++TAG+ + SR+DL++ N ++K + + + DT + +
Sbjct: 63 ICCDDDLSCTANSDITIITAGMARTGEMSRIDLMKGNAKIVKNYVKNIANFG-DTKIFMI 121
Query: 459 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
SNPVD++TY SG K++V G GT+LDS R
Sbjct: 122 SNPVDLMTYKALIESGYEKNQVFGLGTHLDSMR 154
>UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;
n=2; Bacteria|Rep: Lactate/malate dehydrogenase
precursor - Bacillus coagulans 36D1
Length = 327
Score = 80.2 bits (189), Expect = 3e-14
Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 7/157 (4%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA--FMRNAKIQ 284
+K+ + GVG VG + + + + IA++D GE +D +H +A +M N ++
Sbjct: 4 TKLVVAGVGHVGSYVLANAMKLGLFSEIAVLDKKKGVAFGEALDWRHATALTYMPNTSVK 63
Query: 285 SSTDYSITAGSKICVVTAGV-----RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 449
+ DYS A + + + AG + E R L + N V+++++ + KY+ + ++
Sbjct: 64 AG-DYSECADADVIICAAGPSVLPSEKDEMPDRAGLARTNAAVVREVMAGITKYTKEAVI 122
Query: 450 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+ +NP+D + Y+ G K R+ G+GT LDSAR+
Sbjct: 123 IFITNPLDTIVYIAENEFGYSKGRIFGTGTMLDSARL 159
>UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium
(Plasmodium)|Rep: Lactate dehydrogenase - Plasmodium
vivax
Length = 299
Score = 80.2 bits (189), Expect = 3e-14
Identities = 41/152 (26%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Frame = +3
Query: 123 IVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQSSTDY 299
+VG G +G A +++ Q ++ + D++ + +G+ +D H + N K+ S Y
Sbjct: 2 LVGSGMIGGVMA-TLIVQKNLGDVVMFDVVKNMPQGKALDTSHSNVMAYSNCKVTGSNSY 60
Query: 300 SITAGSKICVVTAGVRQREGES-----RLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
G+ + +VTAG + G+S R DL+ N ++ +I + P+ +++ +N
Sbjct: 61 DDLKGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKNLCPNAFIIVVTN 120
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
PVD++ + ++ SG+PK+++IG G LD++R+
Sbjct: 121 PVDVMVQLLFEHSGVPKNKIIGLGGVLDTSRL 152
>UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|Rep:
Malate dehydrogenase - Plasmodium falciparum
Length = 313
Score = 79.8 bits (188), Expect = 5e-14
Identities = 43/150 (28%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQS 287
+K+ ++G GQ+G L +N+ ++ L D++ +G+ +DL+H S + N I
Sbjct: 2 TKIALIGSGQIGAIVGELCLLENL-GDLILYDVVPGIPQGKALDLKHFSTILGVNRNILG 60
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
+ + I V+TAGV+++EG +R DL+ N ++K + + + ++ SNP
Sbjct: 61 TNQIEDIKDADIIVITAGVQRKEGMTREDLIGVNGKIMKSVAESVKLHCSKAFVICVSNP 120
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+DI+ V K S LP ++ G LD++R
Sbjct: 121 LDIMVNVFHKFSNLPHEKICGMAGILDTSR 150
>UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
phytofermentans ISDg|Rep: L-lactate dehydrogenase -
Clostridium phytofermentans ISDg
Length = 319
Score = 78.2 bits (184), Expect = 1e-13
Identities = 39/151 (25%), Positives = 78/151 (51%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
KV I+G G VG A +++ Q + I +D+ +K K + +D+ + ++ + S
Sbjct: 6 KVIIIGAGHVGSHAGYALAEQGLAEEIIFIDIDREKAKAQALDIYDATVYLPHRVKVKSG 65
Query: 294 DYSITAGSKICVVTAGVR--QREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
DYS A + + V+ G + +GE+R+ + ++K++ + D ++V SNP
Sbjct: 66 DYSDAADADLMVIAVGTNPDKNKGETRMSTLTNTALIIKEVAWHIKNSGFDGMIVSISNP 125
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D++T+ + +++I + T LDSAR+
Sbjct: 126 ADVITHYLQHLLQYSSNKIISTSTVLDSARL 156
>UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10;
Campylobacter|Rep: L-lactate dehydrogenase -
Campylobacter jejuni
Length = 308
Score = 78.2 bits (184), Expect = 1e-13
Identities = 52/152 (34%), Positives = 80/152 (52%), Gaps = 2/152 (1%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAF-MRNAKIQS 287
+K+ IVG+G VG A+A+S++ Q + + + L D+ D DL+ SA KI
Sbjct: 2 AKIGIVGLGYVGAASAYSIVIQGICSELYLYDIKQDLALAHARDLEDMSAIHFSYTKIFH 61
Query: 288 STDYSITAGSKICVVTAGVRQ-REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
+ A I ++ +E SRL ++ N LK I+ L + ++A+N
Sbjct: 62 VPNLENLASCDIIILAFRKESLKELPSRLVELKNNILELKDIVLTLKNANFKGKYIVATN 121
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
P D +TY T +S LPK+ V GSGTNLDS+R+
Sbjct: 122 PNDTITYYTQVLSQLPKNHVFGSGTNLDSSRL 153
>UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3;
Eimeriorina|Rep: Lactate dehydrogenase - Eimeria tenella
Length = 331
Score = 77.8 bits (183), Expect = 2e-13
Identities = 46/164 (28%), Positives = 86/164 (52%), Gaps = 6/164 (3%)
Frame = +3
Query: 84 VHEKVDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAF 263
V EKV K+ +VG G +G F + + ++ L D++ + G+ +DL H +A
Sbjct: 3 VFEKVRRP--KIALVGSGMIGGTMGF-LCSLRELGDVVLFDVVPNMPAGKALDLCHTAAV 59
Query: 264 MRNA-KIQSSTDYSITAGSKICVVTAGVRQREGES-----RLDLVQRNTDVLKQIIPQLI 425
N ++Q + Y+ G+ + ++TAG+ + G+S R DL+ N +L+++ +
Sbjct: 60 ADNGVRVQGANSYASLEGADVVIITAGITKAAGKSDQEWSRKDLLPVNVKILREVGAAIK 119
Query: 426 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
++ P ++ +NP+D++ + +GLP RV G LDSAR
Sbjct: 120 QFCPHAFVINITNPLDVMVAALREAAGLPAARVCGMAGVLDSAR 163
>UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=2;
Oenococcus oeni|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 304
Score = 77.4 bits (182), Expect = 2e-13
Identities = 47/151 (31%), Positives = 80/151 (52%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ I+G+G VG + ++ + + + I L+D+ LK E +D +F+ + +
Sbjct: 3 KIGIIGMGHVGSTLSHIVIDRGMVDEIVLLDINQKHLKAEALDFWDAQSFLPHHTKIIAG 62
Query: 294 DYSITAGSKICVVTAGVRQREGES--RLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
DY A + + V T G ES R +Q N ++ + QL K D + + +NP
Sbjct: 63 DYKDLADANLIVSTFGNVNLTVESGDRFAELQFNVKQIRSMAEQLKKVHFDGVFLTITNP 122
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
VD++T V + LPK++VIG+GT LDS+R+
Sbjct: 123 VDVITAVYQRELALPKNQVIGTGTFLDSSRL 153
>UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter
hepaticus|Rep: Malate dehydrogenase - Helicobacter
hepaticus
Length = 315
Score = 77.0 bits (181), Expect = 3e-13
Identities = 45/153 (29%), Positives = 79/153 (51%), Gaps = 2/153 (1%)
Frame = +3
Query: 108 WSKVTIVG-VGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSA-FMRNAKI 281
+ K+ I+G G VG AF +++ I L + KG +D+ +A F I
Sbjct: 2 FEKIAIIGGSGNVGSHIAFLGAMRHIAKEILLFSNDIPRCKGVGLDISQAAAIFDIPILI 61
Query: 282 QSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 461
+ Y A S++ ++TAG + +R DL+ +N ++++I + + +P ++L++ S
Sbjct: 62 KGCNSYEEIAESEVVIITAGFPRTPNMTRNDLLLKNASIIQEISSNVARIAPQSLLIVVS 121
Query: 462 NPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
NP+D + V + S K RVIG LDSAR+
Sbjct: 122 NPLDAMCLVAKQWSKFEKERVIGMAGILDSARL 154
>UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase;
n=15; Lactobacillales|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus confusus
Length = 310
Score = 76.6 bits (180), Expect = 4e-13
Identities = 45/161 (27%), Positives = 86/161 (53%), Gaps = 4/161 (2%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ I+G+G VG A A ++ Q V ++ +D K+K + +D Q A +
Sbjct: 4 KIGIIGLGNVGAAVAHGLIAQGVADDYVFIDANEAKVKADQIDFQDAMANLEAHGNIVIN 63
Query: 294 DYSITAGSKICVVTAGVRQREGES----RLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 461
D++ A + + + T G + + ++ R ++ + +++ + L + +LV+ S
Sbjct: 64 DWAALADADVVISTLGNIKLQQDNPTGDRFAELKFTSSMVQSVGTNLKESGFHGVLVVIS 123
Query: 462 NPVDILTYVTWKISGLPKHRVIGSGTNLDSARVPLPAXGQA 584
NPVD++T + ++G P H+VIG+GT LD+AR+ A G+A
Sbjct: 124 NPVDVITALFQHVTGFPAHKVIGTGTLLDTARMQ-RAVGEA 163
>UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=3;
Streptococcus thermophilus|Rep: L-2-hydroxyisocaproate
dehydrogenase - Streptococcus thermophilus (strain CNRZ
1066)
Length = 316
Score = 76.2 bits (179), Expect = 6e-13
Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K+ I+G+G VG A A + Q + ++ +D+ K++ + D + A + N
Sbjct: 4 KIGIIGMGNVGAAVAHGAIAQGLADSYVFIDINERKVEADAQDFKDAMANLANYANIVVN 63
Query: 294 DYSITAGSKICVVTAG---VRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
DY + + + G ++ GE R + + Q+ +L + IL++ SN
Sbjct: 64 DYEALKDADVIISALGNIQLQHNAGEDRFAEFPFTREAVYQVAQELKQLDFKGILLVISN 123
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
PVD +T + + +G PK RVIG+GT LD+AR+
Sbjct: 124 PVDAVTALYQEFTGWPKERVIGTGTLLDTARM 155
>UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=2;
Lactobacillus plantarum|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus plantarum
Length = 319
Score = 74.1 bits (174), Expect = 2e-12
Identities = 41/152 (26%), Positives = 77/152 (50%), Gaps = 3/152 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST 293
K I+GVG VG A++++ + + + + L+D A K + E +DLQ A + + I
Sbjct: 3 KYAIIGVGHVGATIAYTLVCKGIADELVLIDTNAAKARAEQLDLQDAQARLDSRTIIKIN 62
Query: 294 DYSITAGSKICVVTAG---VRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
DY + I VT+G +R + +++ I P++ + +++ N
Sbjct: 63 DYHELDDTDILFVTSGNIHALDHASGNRWAEFEYTKQIVQDIAPKVKATKFNGVVIDTMN 122
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
P D +T+ + +GL + +V G+GT LD+AR+
Sbjct: 123 PCDAITHYFQRATGLSRQQVFGTGTFLDTARM 154
>UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1;
Methanoculleus marisnigri JR1|Rep: Lactate/malate
dehydrogenase - Methanoculleus marisnigri (strain ATCC
35101 / DSM 1498 / JR1)
Length = 288
Score = 74.1 bits (174), Expect = 2e-12
Identities = 46/150 (30%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+ + I+GVG+VG AF + + I + D+ L+ +++DLQH + S
Sbjct: 2 TSLAILGVGKVGGETAFLSAALGLVDEIVVYDVYEPLLRAQVLDLQH-----TGIDVAIS 56
Query: 291 TDYSITAGSKICVVTAGV-RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
T+ + + I V AG R + ++R DL++ N V K+ +L++ P ++ + +NP
Sbjct: 57 TETAAMRDADIFVFAAGTPRTPDIKTRADLLEANIPVAKRC-SELLEGFPGVVISV-TNP 114
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+D Y WK+ G+ + R IG G+ LDSAR
Sbjct: 115 MDANNYGLWKMMGIDRRRCIGFGSQLDSAR 144
>UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1;
Lactobacillus sakei subsp. sakei 23K|Rep: Putative
malate dehydrogenase - Lactobacillus sakei subsp. sakei
(strain 23K)
Length = 301
Score = 73.3 bits (172), Expect = 4e-12
Identities = 42/152 (27%), Positives = 76/152 (50%), Gaps = 2/152 (1%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+KV I+G+G VG A++++++ + + + L D + E DL+ G ++
Sbjct: 2 NKVAIIGIGHVGSTVAYTLVSRRICSELVLFDQKPKLAEAERNDLEAGQVDHTGFVKITA 61
Query: 291 TDYSITAGSKICVVTAGVRQ--REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
D S A + + +AG + R D + + Q P+L + IL+ +N
Sbjct: 62 NDESQLATCDLVIFSAGDISILEHSDDRFDELTYTKTAVAQWAPKLKAANFKGILLNITN 121
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
P D++T ++G PK RV+G+GT LD+AR+
Sbjct: 122 PCDVITQYLQALTGFPKERVLGTGTTLDTARM 153
>UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 325
Score = 73.3 bits (172), Expect = 4e-12
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 2/151 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSS 290
K+ +VG G VG A S+L Q + + + L D+ K+ E+ DL+ +F+ N KI +
Sbjct: 6 KIGVVGQGHVGAHVANSLLMQGIADELYLCDINEAKVTSEVQDLRDSLSFVPYNTKIVNC 65
Query: 291 TD-YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
D Y A + V AG +R + TD + +++ D I V SNP
Sbjct: 66 YDHYEELACCDVIVNAAGKVALAAGNRDGELFFTTDAARSFAKRIVDAGFDGIFVSISNP 125
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D++ W ++G ++IGSG LDSAR+
Sbjct: 126 CDVVCTELWHLTGYDPKKIIGSGCGLDSARL 156
>UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2;
Methanomicrobiales|Rep: Lactate/malate dehydrogenase -
Methanospirillum hungatei (strain JF-1 / DSM 864)
Length = 290
Score = 70.1 bits (164), Expect = 4e-11
Identities = 43/149 (28%), Positives = 72/149 (48%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
+ + + G G++G A ++ + N++ L D L+ + +D++H MR S
Sbjct: 2 TSLAVFGTGRIGGGVAARAVSSGLINHLVLYDCNQALLEAQRLDIEH----MRCPVTTSI 57
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
I A I R + ++R L+ N V ++ + Y I+++ +NP
Sbjct: 58 RPEDIVACDIILYAAGLPRNQNIKTRAALLDCNVPVASELATLIPDYKG--IIIVVTNPA 115
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSAR 557
DILTY WK G+ K+R+IG G LDSAR
Sbjct: 116 DILTYYLWKSLGILKNRIIGFGGQLDSAR 144
>UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 321
Score = 69.7 bits (163), Expect = 5e-11
Identities = 42/157 (26%), Positives = 78/157 (49%), Gaps = 8/157 (5%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAF--MRNAKIQS 287
K+ I+GVG+VG A + + I ++D+ G+ +D H +A + N + +
Sbjct: 7 KLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNEKLAAGQALDQHHATALPNVTNVAVYA 66
Query: 288 STDYSITAGSKICVVTAGVR------QREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 449
DY + + + ++TAG G +R +L N +++ + Q+ + D +
Sbjct: 67 G-DYDDLSNADVIIMTAGPSIDASNGPATGAARRELAATNGKIIRSTMTQITSRNHDAAI 125
Query: 450 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+I SNP+D L ++ P+ V+G+GT LDSAR+
Sbjct: 126 IICSNPLDALVHIASTEFDHPQGLVLGTGTILDSARM 162
>UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6;
Plasmodium|Rep: Oxidoreductase, putative - Plasmodium
falciparum (isolate 3D7)
Length = 334
Score = 67.3 bits (157), Expect = 3e-10
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 7/156 (4%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA-KIQSS 290
K++++G G +G A A + +N+ ++ L D D KG +D+ H R+ I +
Sbjct: 8 KISVLGAGDIGCALAHMICEKNL-GDVVLHDFRKDLPKGRALDILHTRPLNRSRINILGT 66
Query: 291 TDYSITAGSKICVVTAGVRQRE----GESRLD--LVQRNTDVLKQIIPQLIKYSPDTILV 452
+ + S + VVT V +RE E L+ + N +LK++ L K+ P +V
Sbjct: 67 NEITDIKDSLVVVVTIEVSEREFAEFDEEDLEKQVYTSNVKLLKEVAKSLKKHCPQAFVV 126
Query: 453 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+ ++PVD + V + + +P H++ G L SAR+
Sbjct: 127 VTTSPVDCMAKVLQEHANIPPHKICGMAGVLHSARL 162
>UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: Enzyme with possible
activities of L-2- hydroxyisocaproate/malate/lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 301
Score = 66.5 bits (155), Expect = 5e-10
Identities = 37/149 (24%), Positives = 73/149 (48%), Gaps = 1/149 (0%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTD 296
+ I+G+G VG+ AF+++++ V + + L+D A+ +GE DL+ + D
Sbjct: 5 IGIIGIGHVGVTTAFNLVSKGVADKLVLIDKKAELAEGESFDLKDALGGLPTYTDIVVND 64
Query: 297 YSITAGSKICVVTAG-VRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
Y + + + G + R+ + + L + P+L +L+ +NP D
Sbjct: 65 YDALKDADVVISAVGNIGAISNGDRIGETKTSKVALDDVAPKLKASGFHGVLLDITNPCD 124
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+T + LPK ++IG+GT+LD+ R+
Sbjct: 125 AVTSYWQYLLDLPKSQIIGTGTSLDTYRM 153
>UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4;
Bacteroidales|Rep: Malate dehydrogenase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 334
Score = 63.3 bits (147), Expect = 4e-09
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 2/154 (1%)
Frame = +3
Query: 105 TWSKVTIVGV-GQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKI 281
T K+TIVG G +G A + +T N+ L D A L+G +++H N
Sbjct: 5 TEEKLTIVGAAGMIGSNMAQTAAMMRLTPNLCLYDPFAVGLEGVAEEIRHCGFEGLNLTF 64
Query: 282 QSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPD-TILVIA 458
S ++T +K V + G ++EG +R DL++ N ++ Q+ + Y PD ++I
Sbjct: 65 TSDIKEALT-DAKYIVSSGGAPRKEGMTREDLLKGNAEIAAQLGKDIKSYCPDCKHVIII 123
Query: 459 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
NP DI VT SGL K + + LDS R+
Sbjct: 124 FNPADITGLVTLIYSGL-KPSQVTTLAGLDSTRL 156
>UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5;
Bacteroidales|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 333
Score = 62.9 bits (146), Expect = 6e-09
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 2/154 (1%)
Frame = +3
Query: 105 TWSKVTIVGV-GQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKI 281
T K+TIVG G +G A + L +T NI L D A L+G +L H AF
Sbjct: 5 TNEKLTIVGAAGMIGSNMAQTALMMKLTPNICLYDPYAPALEGVAEELYH-CAFEGVNLT 63
Query: 282 QSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDT-ILVIA 458
+S +G+K V + G ++ G +R DL++ N ++ Q + +Y PD +V+
Sbjct: 64 YTSDIKEALSGAKYIVSSGGAARKAGMTREDLLKGNAEIAAQFGKDIRQYCPDVKHVVVV 123
Query: 459 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
NP DI + +GL K + + LDS R+
Sbjct: 124 FNPADITGLIVLLYAGL-KPSQVSTLAALDSTRL 156
>UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;
Theileria|Rep: L-lactate dehydrogenase, putative -
Theileria annulata
Length = 367
Score = 62.9 bits (146), Expect = 6e-09
Identities = 27/90 (30%), Positives = 53/90 (58%)
Frame = +3
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
T T G + A + E +R DLV N+ +++ + + KY+P+ +++ +NP+
Sbjct: 118 TAMECTMGKGARLAKAPTKSNEEWNRDDLVGYNSKIIRDVGENIKKYAPEAFVIVITNPM 177
Query: 471 DILTYVTWKISGLPKHRVIGSGTNLDSARV 560
D++ ++ K++G PK+ V+G G LDS+R+
Sbjct: 178 DVMVHLMLKVTGFPKNMVVGMGGLLDSSRM 207
Score = 39.1 bits (87), Expect = 0.078
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 2/85 (2%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQ-NVTNNIALVDMMADKLKGEMMDLQHGSAFMRNA-KIQSS 290
++++G G +G + LTQ ++ D++ + G+ +D+ H ++ A K + +
Sbjct: 10 ISLIGSGNIGGIMGY--LTQLTELADVNFFDIVPNIGAGKSLDIMHANSIQGKAYKCKGT 67
Query: 291 TDYSITAGSKICVVTAGVRQREGES 365
+Y +GS +C+VTAG E S
Sbjct: 68 NNYEDISGSDVCIVTAGNSYEENNS 92
>UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH -
Lactobacillus acidophilus
Length = 304
Score = 62.5 bits (145), Expect = 7e-09
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 3/152 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQ-SS 290
KV I+G+G VG A+++ T + + + L+D DK+ E DL+ S N ++ +
Sbjct: 3 KVGIIGMGHVGATVAYTLFTHGIADELVLIDKNEDKVAAEYNDLR-DSLSRNNYYVRVTM 61
Query: 291 TDYSITAGSKICVVTAG--VRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
D+ + I V G + R + N K++ ++ +L+ SN
Sbjct: 62 QDWHELKDADIIVTAFGDIAASVKTGDRFGEFELNAKNAKEVGEKIKNTGFKGVLLNISN 121
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
P D + + + +GL K++V+G+GT LD+AR+
Sbjct: 122 PCDAVAQILQETTGLSKNQVLGTGTFLDTARM 153
>UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
gallisepticum|Rep: L-lactate dehydrogenase - Mycoplasma
gallisepticum
Length = 323
Score = 62.1 bits (144), Expect = 1e-08
Identities = 40/155 (25%), Positives = 71/155 (45%), Gaps = 7/155 (4%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAKIQSS 290
K+ ++G G VG +L Q V + LVD + G + DL+ + N +
Sbjct: 3 KIAVIGCGFVGSTYILDLLQQGVQADYLLVDKNTNLADGHVRDLRDSKSLKSHNGSTFNV 62
Query: 291 TDYSITAGSKICVVTAG---VRQREGE---SRLDLVQRNTDVLKQIIPQLIKYSPDTILV 452
Y + + +TA V +GE RL L+ N +L +I +L + + +
Sbjct: 63 GTYDDLKDADVVAITASIPTVPTADGEVFTDRLQLMTANVKILNEIALELKRVGFKGLSI 122
Query: 453 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
I +NP D++ V K++G H++I +G L++ R
Sbjct: 123 IPTNPCDVMAGVYQKVTGFDPHKIISTGCQLETMR 157
>UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 322
Score = 60.1 bits (139), Expect = 4e-08
Identities = 37/156 (23%), Positives = 80/156 (51%), Gaps = 8/156 (5%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSST- 293
+ ++G+G VG + + + I+L+D+ G+ +D H + + A + T
Sbjct: 7 LVVIGIGHVGSDVVTNAAALGLFSRISLIDVDKKVRDGQALD-NHQATAVAPAMTTTITA 65
Query: 294 -DYSITAGSKICVVTAG---VRQREG---ESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 452
+Y + + +V+AG + G +SR L Q N+ V+++++ + +Y+ ++
Sbjct: 66 ANYDACRSADVIIVSAGPSVLPDSYGGGHDSRNSLAQVNSKVIREVMGNICQYTHSAPII 125
Query: 453 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
+ +NP+D+ ++ P + V+G+GT LDSAR+
Sbjct: 126 LITNPLDVNVHIAATEFDYPTNLVVGTGTALDSARL 161
>UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1;
Methanocorpusculum labreanum Z|Rep: Lactate/malate
dehydrogenase - Methanocorpusculum labreanum (strain
ATCC 43576 / DSM 4855 / Z)
Length = 283
Score = 55.6 bits (128), Expect = 8e-07
Identities = 40/148 (27%), Positives = 71/148 (47%), Gaps = 1/148 (0%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTD 296
V +GVG++G A+ + + + L D+ + +D+ HG I ST+
Sbjct: 4 VACLGVGRIGGEVAYVSALRKFADELVLFDISEPLQHAQKLDIIHGM------DIPVSTN 57
Query: 297 YSITAGSKICVVTAGV-RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 473
+ + C+ +AG R ++R DL +N + K+ L +S L++ +NP+D
Sbjct: 58 PADLKDADYCIFSAGYSRSPNIKTRADLFDKNLPIAKESSELLKGFSGK--LIVVTNPMD 115
Query: 474 ILTYVTWKISGLPKHRVIGSGTNLDSAR 557
+ T+ K S L + +V+G G LDS R
Sbjct: 116 VFTWYFAKKSCLDESQVVGFGGLLDSRR 143
>UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1;
Endoriftia persephone 'Hot96_1+Hot96_2'|Rep: Malate
dehydrogenase NAD-dependent - Endoriftia persephone
'Hot96_1+Hot96_2'
Length = 170
Score = 55.2 bits (127), Expect = 1e-06
Identities = 23/62 (37%), Positives = 39/62 (62%)
Frame = +3
Query: 372 DLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDS 551
DL+ N V K++ + +++PD +++ +NP+D + Y K+SGLP R+IG LD+
Sbjct: 17 DLLDINLSVTKKVATAVKQHAPDAFVILTTNPLDSIVYAFHKLSGLPAERIIGMAGALDT 76
Query: 552 AR 557
AR
Sbjct: 77 AR 78
>UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 365
Score = 54.4 bits (125), Expect = 2e-06
Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 7/155 (4%)
Frame = +3
Query: 114 KVTIVGV-GQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
KV ++G G +G + + +++AL D+ +D G DL H + +
Sbjct: 3 KVCVLGASGGIGQPLSLLLKLNPYVSDLALYDI-SDITAGVAKDLSHINTNSDSEGYNKD 61
Query: 291 TDY-SITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSP-DTILVIASN 464
D+ ++ GS++ +VTAG+ ++ G +R DL + N +++ + + K++P L+I SN
Sbjct: 62 EDFKNLLEGSELVIVTAGIPRKPGMTRDDLFKINAKIIQNLTVKYAKFAPVHCKLLIISN 121
Query: 465 PVDILTYV---TWKISG-LPKHRVIGSGTNLDSAR 557
PV+ L V T KI+G L +V G T LD R
Sbjct: 122 PVNSLIPVVIETLKINGRLNPSQVFGI-TMLDIIR 155
>UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
agalactiae
Length = 323
Score = 53.2 bits (122), Expect = 4e-06
Identities = 37/152 (24%), Positives = 69/152 (45%), Gaps = 3/152 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFM-RNAK-IQS 287
K+ +VG+G VG + + + + LVD + D + + M RN +
Sbjct: 3 KIIVVGLGNVGFTYINTSVARGLEAEWVLVDKNVQIAEAHAHDFEDMVSLMPRNGSTFRP 62
Query: 288 STDYSITAGSKICVVTAGV-RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
T + + + V+TA + + R+ L N +++ L I+V+A+N
Sbjct: 63 GTLLEDSKDADVVVITASIPADKTFSDRMALAGANAKLMQSFAKDLDAAGFKGIVVVAAN 122
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
P D++ S +P +RVI +GTNL++ R+
Sbjct: 123 PCDVMAAAVHYGSKIPANRVISAGTNLETGRL 154
>UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1;
Streptomyces avermitilis|Rep: Putative lactate
dehydrogenase - Streptomyces avermitilis
Length = 303
Score = 52.8 bits (121), Expect = 6e-06
Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 3/153 (1%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADK---LKGEMMDLQHGSAFMRNAKIQS 287
V +VG G VG A +++ + + +V ++ L ++ D++ + + +
Sbjct: 4 VGVVGAGAVGQTVAATLVASGICPRLLVVSRTVEQARALAADLDDMRQTTGSPVQPEARR 63
Query: 288 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
D + V A R + R+ N V++ + L Y T+LV+ +NP
Sbjct: 64 VADLIGCHAVVVAVRAAFTNTRAADVRMGGALTNAPVIRALATTLRGYQ-GTVLVV-TNP 121
Query: 468 VDILTYVTWKISGLPKHRVIGSGTNLDSARVPL 566
VD++T + + SG P RV G G+NLDSAR L
Sbjct: 122 VDLMTRLFAETSGCP--RVYGIGSNLDSARYRL 152
>UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3;
Leishmania|Rep: Malate dehydrogenase, putative -
Leishmania major
Length = 331
Score = 52.8 bits (121), Expect = 6e-06
Identities = 30/126 (23%), Positives = 65/126 (51%), Gaps = 1/126 (0%)
Frame = +3
Query: 114 KVTIVGV-GQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
KVT++G G +G A +++ + +AL D++ + G +DL H ++ +
Sbjct: 10 KVTVLGASGAIGQPLALALVQNKRVSELALYDIVQPR--GVAVDLSHFPRKVKVTGYPTK 67
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 470
+ G+ + +++AG+ +R G + DL N + ++ + +Y+P ++L I SNP+
Sbjct: 68 WIHKALDGADLVLMSAGMPRRPGMTHDDLFNTNALTVNELSAAVARYAPKSVLAIISNPL 127
Query: 471 DILTYV 488
+ + V
Sbjct: 128 NSMVPV 133
>UniRef50_Q1U8H4 Cluster: L-lactate dehydrogenase; n=2;
Lactobacillus reuteri|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri 100-23
Length = 307
Score = 50.0 bits (114), Expect = 4e-05
Identities = 37/152 (24%), Positives = 73/152 (48%), Gaps = 3/152 (1%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVD---MMADKLKGEMMDLQHGSAFMRNAKIQ 284
K+ I+G+G VG A ++ + + L+D +A ++ ++ D Q A IQ
Sbjct: 3 KIGIIGLGHVGEMLANQLVMNGKVDELVLIDEKDQLAIAIQADLNDAQTVLATHTKIIIQ 62
Query: 285 SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 464
DY+ A + + + G + + ++ + Q+ ++ K IL+ +N
Sbjct: 63 ---DYAALADADVLITAFGKSALMKQQPMAELETSYQQALQVGNKVFKSDFSGILINLTN 119
Query: 465 PVDILTYVTWKISGLPKHRVIGSGTNLDSARV 560
P + +T V + GLP+ +VIG GT +++AR+
Sbjct: 120 PNEAITAVLQQKVGLPQKQVIGIGTVVETARL 151
>UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=1;
Entamoeba histolytica|Rep: NAD-specific malate
dehydrogenase 2 - Entamoeba histolytica
Length = 329
Score = 48.0 bits (109), Expect = 2e-04
Identities = 49/168 (29%), Positives = 77/168 (45%), Gaps = 8/168 (4%)
Frame = +3
Query: 78 QPVH-EKVDETWS-KVTIVGV-GQVGMAAAFSM---LTQNVTNNIALVDMMADKLKGEMM 239
QP+ EKV+ T V I G GQ+G F + + + L D+ LKG M
Sbjct: 3 QPIPWEKVNRTEPLHVLITGAAGQIGYNLCFLIGRGFLFDCDVILHLYDLNDMALKGLSM 62
Query: 240 DLQHGSAFMRNAKIQSSTDYSITAGS-KICVVTAGVRQREGESRLDLVQRNTDVLKQIIP 416
+L + I S+T+ ++ + + ++ AGV ++ G R DL+ N V++
Sbjct: 63 ELTD-CCLPKLKGIISTTEIALAFSNVDVAIIVAGVPRKPGMQRSDLINVNKKVMEMNGK 121
Query: 417 QLIKYS-PDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 557
L YS D +V+ +NP + YV K SG+P + T LD R
Sbjct: 122 ALGTYSNKDVRVVVVANPANTNAYVICKTSGIPPEHITAL-TRLDQNR 168
>UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa
triquetra|Rep: Malate dehydrogenase - Heterocapsa
triquetra (Dinoflagellate)
Length = 402
Score = 47.2 bits (107), Expect = 3e-04
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 3/85 (3%)
Frame = +3
Query: 312 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYV- 488
G + ++ AG+ ++ G++R DL + N D+ K I+ KY PD +L + NPV+ +
Sbjct: 158 GCHLVLIPAGMPRKPGQTRDDLFKINADIAKGIVEACAKYCPDAMLGMIVNPVNSVVPAM 217
Query: 489 --TWKISGLPKHRVIGSGTNLDSAR 557
+K GL +++G T LD R
Sbjct: 218 AELYKKKGLDPMKIVGI-TTLDVVR 241
>UniRef50_Q01JC3 Cluster: Malate dehydrogenase; n=8; cellular
organisms|Rep: Malate dehydrogenase - Oryza sativa
(Rice)
Length = 352
Score = 39.5 bits (88), Expect = 0.059
Identities = 33/147 (22%), Positives = 65/147 (44%), Gaps = 3/147 (2%)
Frame = +3
Query: 126 VGVGQVGMAAAFSMLTQNVTNNIALVDM--MADKLKGEMMDLQHGSAFMRNAKIQSSTDY 299
+G V M A ML + + L+D+ A+ L G M+L + + + +S +
Sbjct: 38 IGYAIVAMIAKGLMLGADQPVVLHLLDLPVAANALNGVRMELIDAALPLLRGVVATSDEA 97
Query: 300 SITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKY-SPDTILVIASNPVDI 476
G + ++ G +R+G R DL+ +N + K L ++ +P+ +++ +NP +
Sbjct: 98 EAFKGVNVAILIGGWPRRDGMERKDLISKNVTIYKSQASALQQHAAPNCKVLVVANPANT 157
Query: 477 LTYVTWKISGLPKHRVIGSGTNLDSAR 557
V + + + I T LD R
Sbjct: 158 NALVLKEFAPAIPAKNITCLTRLDHNR 184
>UniRef50_Q75AT4 Cluster: ADL164Cp; n=2; Saccharomycetales|Rep:
ADL164Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 381
Score = 39.5 bits (88), Expect = 0.059
Identities = 30/112 (26%), Positives = 53/112 (47%), Gaps = 8/112 (7%)
Frame = +3
Query: 177 NVTNNIALVDMMADKLKGEMMDLQHGSAFMR-NAKIQSSTD-----YSITAGSKICVVTA 338
N + +AL D+ AD L G DL H + + + + SS + G+ + V+ A
Sbjct: 55 NASLELALYDVAADALAGVAADLSHVNTPVEVSHHVPSSREDEEALREALTGASVVVIPA 114
Query: 339 GVRQREGESRLDLVQRNTDVLKQIIPQLIKYS--PDTILVIASNPVDILTYV 488
GV ++ G +R DL+ N ++K + + +++ SNPV+ L V
Sbjct: 115 GVPRKPGMTRDDLININAGIIKTLAKGIAGACDLEKVFVLVISNPVNSLVPV 166
>UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;
n=2; Apis mellifera|Rep: PREDICTED: similar to CG7998-PA
- Apis mellifera
Length = 333
Score = 39.1 bits (87), Expect = 0.078
Identities = 18/63 (28%), Positives = 36/63 (57%)
Frame = +3
Query: 312 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVT 491
G+KI ++ V R ++++ N +L ++P +IK+SP +L I NP++ L +T
Sbjct: 70 GAKIVMI---VTDRTSNESNEVLKSNAIILSDLLPNIIKFSPQAMLAIVMNPINSLIPLT 126
Query: 492 WKI 500
++
Sbjct: 127 MEM 129
>UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces
cerevisiae YOL126c MDH2 malate dehydrogenase; n=1;
Kluyveromyces lactis|Rep: Similar to sp|P22133
Saccharomyces cerevisiae YOL126c MDH2 malate
dehydrogenase - Kluyveromyces lactis (Yeast) (Candida
sphaerica)
Length = 404
Score = 37.5 bits (83), Expect = 0.24
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Frame = +3
Query: 192 IALVDMMADKLKGEMMDLQH-GSAFMRNAKIQSSTDYSI---TAGSKICVVTAGVRQREG 359
++L D+ D + G DL H + A ++ I + + + ++ AGV ++ G
Sbjct: 84 LSLYDVNKDAIVGTAADLSHIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPG 143
Query: 360 ESRLDLVQRNTDVLKQIIPQLIKYSP--DTILVIASNPVDIL 479
SR DL+ N ++K + + KY +++ SNP++ L
Sbjct: 144 MSRDDLIGVNAKIIKSLGEDIAKYCDLNKVHVLVISNPINSL 185
>UniRef50_Q0JBC2 Cluster: Os04g0542900 protein; n=8;
Magnoliophyta|Rep: Os04g0542900 protein - Oryza sativa
subsp. japonica (Rice)
Length = 519
Score = 37.1 bits (82), Expect = 0.32
Identities = 30/78 (38%), Positives = 37/78 (47%), Gaps = 2/78 (2%)
Frame = +2
Query: 50 QDGVPEEAVPARAREGGRNLEQGDHCRGRSGWDGRSFLYADAECYE*--HRSSRHDG*QI 223
+D P PAR E GR GD R RS W + E E HR+SR DG Q
Sbjct: 84 EDDAPRRHRPAREEEEGR----GDE-RSRSTWAEVVSDHKGGEAEERPDHRNSRRDGRQ- 137
Query: 224 ERRDDGPAARISIHEERQ 277
ERR+DG R+ ++ Q
Sbjct: 138 ERREDGDWERVDGRKQHQ 155
>UniRef50_UPI0000DB7CDC Cluster: PREDICTED: similar to CTD
(carboxy-terminal domain, RNA polymerase II, polypeptide
A) small phosphatase like 2; n=1; Apis mellifera|Rep:
PREDICTED: similar to CTD (carboxy-terminal domain, RNA
polymerase II, polypeptide A) small phosphatase like 2 -
Apis mellifera
Length = 486
Score = 35.9 bits (79), Expect = 0.73
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 7/89 (7%)
Frame = -3
Query: 406 CLSTSVFLCTRSRRDSPSRCRTPAVTTQIFEPAVIE*SVLDW------ILAFLMNADPCC 245
C+ S+ T R S TPA T + + V E S +W + + ++N D CC
Sbjct: 97 CIKRSMVTSTPLHRTSTKNAVTPAKCTTVSK--VSEESKENWNVTSLSLYSSILNTDTCC 154
Query: 244 RSIISPFNL-SAIMSTRAMLFVTFCVSIE 161
SI S + S+I +TR++ + T C E
Sbjct: 155 SSISSVNDFKSSISNTRSLYYSTSCSQTE 183
>UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5;
Protostomia|Rep: Malate dehydrogenase - Drosophila
melanogaster (Fruit fly)
Length = 347
Score = 35.9 bits (79), Expect = 0.73
Identities = 28/124 (22%), Positives = 53/124 (42%), Gaps = 2/124 (1%)
Frame = +3
Query: 114 KVTIVG-VGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
KV +VG VG +G + + + ++L D+ G +DL H + +
Sbjct: 29 KVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIK--NTTGVGVDLSHINTRASVCPFEGK 86
Query: 291 TDYSITAG-SKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 467
+ I V+ AG+ ++ G R DLV N V ++ + P +L +NP
Sbjct: 87 NGLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFITNP 146
Query: 468 VDIL 479
++++
Sbjct: 147 INVI 150
>UniRef50_UPI0000E45EC5 Cluster: PREDICTED: similar to CG10662-PA;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to CG10662-PA - Strongylocentrotus purpuratus
Length = 217
Score = 34.3 bits (75), Expect = 2.2
Identities = 30/115 (26%), Positives = 56/115 (48%), Gaps = 8/115 (6%)
Frame = +3
Query: 78 QPVHEKVDETWSKVTIVGV-GQVG-------MAAAFSMLTQNVTNNIALVDMMADKLKGE 233
Q + E+ TWS+ ++ G+VG + AAF N+TN + + AD+ GE
Sbjct: 84 QHIRERTWSTWSRHSVHSTTGRVGSLGGRAHVVAAFEQSLSNMTNRLQRLTSTADQKDGE 143
Query: 234 MMDLQHGSAFMRNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDV 398
+ DL+ ++ A I ++T ++ G ++ G + +S +L + NT+V
Sbjct: 144 LQDLREKIEQLKVAHI-TNTQGLLSNG-----LSNGALNGQKKSSGNLTRENTEV 192
>UniRef50_A0QSN0 Cluster: Ftsk/spoiiie family protein; n=1;
Mycobacterium smegmatis str. MC2 155|Rep: Ftsk/spoiiie
family protein - Mycobacterium smegmatis (strain ATCC
700084 / mc(2)155)
Length = 1211
Score = 34.3 bits (75), Expect = 2.2
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Frame = +3
Query: 129 GVGQVGMAAA--FSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTDYS 302
G +G+A+A S L N+++ A+V MAD L GEM Q +R A + S+ +Y+
Sbjct: 443 GATFLGLASAPHISALITNLSDEAAMVARMADALAGEMTRRQE---LLRAANVGSAAEYT 499
Query: 303 ITAG 314
T G
Sbjct: 500 RTNG 503
>UniRef50_Q2QQV8 Cluster: Retrotransposon protein, putative,
unclassified; n=7; Oryza sativa|Rep: Retrotransposon
protein, putative, unclassified - Oryza sativa subsp.
japonica (Rice)
Length = 1621
Score = 34.3 bits (75), Expect = 2.2
Identities = 18/54 (33%), Positives = 27/54 (50%)
Frame = +2
Query: 38 LTEPQDGVPEEAVPARAREGGRNLEQGDHCRGRSGWDGRSFLYADAECYE*HRS 199
LTEP+ G PEE V + R ++G+ ++G + LY DA HR+
Sbjct: 310 LTEPEKGGPEEGVGGKRRRSAGGGDEGEKPTKKAGLAIQPCLYGDAHSETKHRT 363
>UniRef50_A2YRW8 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 127
Score = 34.3 bits (75), Expect = 2.2
Identities = 18/46 (39%), Positives = 31/46 (67%), Gaps = 4/46 (8%)
Frame = +3
Query: 363 SRLDLVQRN--TDVLKQIIPQLIKYSPDTILVIASNPV--DILTYV 488
++L+L++ N +L +I+P L + SP+ LV+ S+P D+LTYV
Sbjct: 3 TKLELMRSNYLKKLLTEIVPALAENSPEAALVVVSDPPVDDVLTYV 48
>UniRef50_Q4Q910 Cluster: Putative uncharacterized protein; n=3;
Leishmania|Rep: Putative uncharacterized protein -
Leishmania major
Length = 2317
Score = 34.3 bits (75), Expect = 2.2
Identities = 16/31 (51%), Positives = 24/31 (77%)
Frame = -3
Query: 571 AGNGTRAESKLVPDPITRCLGSPLIFHVTYV 479
+G+G+ A+S L P P+T+CLG+P FH TY+
Sbjct: 950 SGSGSGAQSFLRPSPLTQCLGAP--FH-TYI 977
>UniRef50_Q8EYH1 Cluster: Methyl-accepting chemotaxis protein; n=2;
Leptospira interrogans|Rep: Methyl-accepting chemotaxis
protein - Leptospira interrogans
Length = 530
Score = 33.9 bits (74), Expect = 2.9
Identities = 20/55 (36%), Positives = 33/55 (60%), Gaps = 1/55 (1%)
Frame = -3
Query: 535 PDPITRCLGSPLIFHVTYVRI-STGLLAITNIVSGLYFISCGIICLSTSVFLCTR 374
PD T + SP+++ ++Y+ I S+GLL + N V + F+S G L ++F TR
Sbjct: 105 PDFTTGVVKSPILYGISYMYIVSSGLLLVPNFVLWIGFLSGGAQAL--AIFTATR 157
>UniRef50_A1S187 Cluster: UBA/THIF-type NAD/FAD binding protein;
n=2; Archaea|Rep: UBA/THIF-type NAD/FAD binding protein
- Thermofilum pendens (strain Hrk 5)
Length = 256
Score = 33.9 bits (74), Expect = 2.9
Identities = 26/97 (26%), Positives = 46/97 (47%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
S V +VG G +G AF ++ V + +VD +L + H ++ + AK++S+
Sbjct: 30 STVLVVGAGGLGSPVAFYLVAAGV-GKLIIVDAEDVELSNLNRQILHWTSDLGKAKVESA 88
Query: 291 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVL 401
+ + VVT + R E L LV+ + DV+
Sbjct: 89 KEKLEKLNPHVEVVTLKQKIRSLEDALKLVE-DADVV 124
>UniRef50_Q15ST6 Cluster: UBA/THIF-type NAD/FAD binding fold; n=2;
Alteromonadales|Rep: UBA/THIF-type NAD/FAD binding fold
- Pseudoalteromonas atlantica (strain T6c / BAA-1087)
Length = 256
Score = 33.5 bits (73), Expect = 3.9
Identities = 23/74 (31%), Positives = 38/74 (51%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSS 290
SKV I+GVG +G AAA +++ + I LVD +L + H + K+ S+
Sbjct: 37 SKVLIIGVGGLGCAAAQYLVSSGI-GEITLVDDDKVELSNLHRQVLHHEQDVGVKKVDSA 95
Query: 291 TDYSITAGSKICVV 332
S+ A + +CV+
Sbjct: 96 KT-SLLANNSLCVI 108
>UniRef50_A0W7C0 Cluster: Diguanylate cyclase/phosphodiesterase with
PAS/PAC sensor; n=2; cellular organisms|Rep: Diguanylate
cyclase/phosphodiesterase with PAS/PAC sensor -
Geobacter lovleyi SZ
Length = 1027
Score = 33.5 bits (73), Expect = 3.9
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Frame = +3
Query: 348 QREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP-VDILTYVTWKISGLPKHRV 524
QRE ++ V++ +Q + +I + PD + VI N V I K+SG+PK +
Sbjct: 318 QREQLAKARAVEQALLDARQQLNDIIDFFPDAVFVIDRNKRVTIWNRAIEKMSGVPKEEM 377
Query: 525 IGSG 536
+G G
Sbjct: 378 LGKG 381
>UniRef50_P40925 Cluster: Malate dehydrogenase, cytoplasmic; n=124;
cellular organisms|Rep: Malate dehydrogenase,
cytoplasmic - Homo sapiens (Human)
Length = 334
Score = 33.5 bits (73), Expect = 3.9
Identities = 28/129 (21%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Frame = +3
Query: 114 KVTIVGV-GQVGMAAAFSMLTQNVTNN-----IALVDM--MADKLKGEMMDLQHGSAFMR 269
+V + G GQ+ + +S+ +V + L+D+ M L G +M+LQ + +
Sbjct: 6 RVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLL 65
Query: 270 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTI- 446
I + + + ++ + +REG R DL++ N + K L KY+ ++
Sbjct: 66 KDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVK 125
Query: 447 LVIASNPVD 473
+++ NP +
Sbjct: 126 VIVVGNPAN 134
>UniRef50_Q6NYY8 Cluster: Smox protein; n=12; Coelomata|Rep: Smox
protein - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 539
Score = 32.7 bits (71), Expect = 6.8
Identities = 14/47 (29%), Positives = 26/47 (55%)
Frame = +3
Query: 114 KVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHG 254
++ ++G G G+AA ++L TN L +D++ G + +QHG
Sbjct: 26 RIVVIGAGLAGLAATKTLLENGFTNVTVL--EASDRIGGRVQSIQHG 70
>UniRef50_Q8FY97 Cluster: Prephenate dehydrogenase; n=75;
Bacteria|Rep: Prephenate dehydrogenase - Brucella suis
Length = 321
Score = 32.7 bits (71), Expect = 6.8
Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 6/127 (4%)
Frame = +3
Query: 108 WSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRN-AKIQ 284
+ K+T++G+G +G + A + + + +IA+ A+ LK +L G ++ N A+
Sbjct: 6 FDKITLIGIGLIGSSLARVIRREGLATHIAIATRSAETLK-RAEELNLGDSYTTNSAEAV 64
Query: 285 SSTD---YSITAGSKICVV--TAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 449
D S+ GS V AG + G D+ V+ Q+ P+L P+ +
Sbjct: 65 KDADLVIVSVPVGSSGTVARQIAG-NLKPGAIVTDVGSTKASVIAQMQPEL----PENVH 119
Query: 450 VIASNPV 470
I +P+
Sbjct: 120 FIPGHPL 126
>UniRef50_Q577J1 Cluster: Alcohol dehydrogenase, zinc-containing;
n=36; Bacteria|Rep: Alcohol dehydrogenase,
zinc-containing - Brucella abortus
Length = 375
Score = 32.7 bits (71), Expect = 6.8
Identities = 18/38 (47%), Positives = 22/38 (57%)
Frame = +3
Query: 111 SKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKL 224
S+V I G+G VG+AA + T IAL DM DKL
Sbjct: 195 SRVAIAGLGGVGLAAVMGAVAAGATEIIAL-DMFDDKL 231
>UniRef50_Q7G3D9 Cluster: Retrotransposon protein, putative,
unclassified; n=5; Oryza sativa|Rep: Retrotransposon
protein, putative, unclassified - Oryza sativa subsp.
japonica (Rice)
Length = 1505
Score = 32.7 bits (71), Expect = 6.8
Identities = 17/54 (31%), Positives = 27/54 (50%)
Frame = +2
Query: 38 LTEPQDGVPEEAVPARAREGGRNLEQGDHCRGRSGWDGRSFLYADAECYE*HRS 199
LT+P+ G PEE V + R ++G+ ++G + LY DA HR+
Sbjct: 351 LTKPEKGGPEEGVGGKRRRSAGGGDEGEKPTKKAGLAIQPCLYGDAHSETKHRT 404
>UniRef50_Q6ZCA3 Cluster: Putative uncharacterized protein
P0547A06.25; n=1; Oryza sativa (japonica
cultivar-group)|Rep: Putative uncharacterized protein
P0547A06.25 - Oryza sativa subsp. japonica (Rice)
Length = 187
Score = 32.7 bits (71), Expect = 6.8
Identities = 17/45 (37%), Positives = 30/45 (66%), Gaps = 4/45 (8%)
Frame = +3
Query: 363 SRLDLVQRN--TDVLKQIIPQLIKYSPDTILVIASNPV--DILTY 485
++L+L++ N +L +I+P L + SP+ LV+ S+P D+LTY
Sbjct: 3 TKLELMRSNYLKKLLTEIVPALAENSPEAALVVVSDPPVDDVLTY 47
>UniRef50_Q74ZH8 Cluster: AGR229Wp; n=2; Eremothecium gossypii|Rep:
AGR229Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 705
Score = 32.7 bits (71), Expect = 6.8
Identities = 16/44 (36%), Positives = 21/44 (47%)
Frame = +2
Query: 41 TEPQDGVPEEAVPARAREGGRNLEQGDHCRGRSGWDGRSFLYAD 172
T ++G E+ P R R RNL +G GWDG + L D
Sbjct: 120 TPEKEGAYEKMTPVRPRAEARNLRAELEQQGSEGWDGVAALLED 163
>UniRef50_Q4P6B5 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 763
Score = 32.7 bits (71), Expect = 6.8
Identities = 17/60 (28%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Frame = +3
Query: 72 LFQPVHEKVDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKL-KGEMMDLQ 248
L P + V E++ + I+G G G+ AA + Q + ++ ++D DK+ G+ LQ
Sbjct: 11 LSAPSGDSVKESYCDILIIGAGPAGLMAANWLAVQGLGPSVRIIDKRNDKIFNGQADGLQ 70
>UniRef50_Q4RTQ4 Cluster: Chromosome 2 SCAF14997, whole genome
shotgun sequence; n=4; Clupeocephala|Rep: Chromosome 2
SCAF14997, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 504
Score = 32.3 bits (70), Expect = 9.0
Identities = 17/49 (34%), Positives = 25/49 (51%)
Frame = +3
Query: 123 IVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMR 269
IV V V +++L N T IA +D A + K +M L+H FM+
Sbjct: 297 IVMVSMVSGCIMYTVLVANATTMIANIDPAAKEYKSKMSRLEHYMTFMK 345
>UniRef50_Q10YD5 Cluster: Monooxygenase, FAD-binding; n=4;
Trichodesmium erythraeum IMS101|Rep: Monooxygenase,
FAD-binding - Trichodesmium erythraeum (strain IMS101)
Length = 489
Score = 32.3 bits (70), Expect = 9.0
Identities = 16/43 (37%), Positives = 24/43 (55%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDL 245
V IVG G VG+A A + + + N I L A + G+++DL
Sbjct: 22 VAIVGAGPVGLATALGLRQRGIENIIVLDQTRAFRKVGQVIDL 64
>UniRef50_Q091H7 Cluster: Oxidoreductase; n=2; Myxococcales|Rep:
Oxidoreductase - Stigmatella aurantiaca DW4/3-1
Length = 481
Score = 32.3 bits (70), Expect = 9.0
Identities = 17/38 (44%), Positives = 24/38 (63%)
Frame = +3
Query: 117 VTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKG 230
V I+G GQ G++ AF +L + VT N+ +VD A L G
Sbjct: 52 VLIIGGGQSGLSVAFGLLREKVT-NVLVVDDNAPGLAG 88
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 582,729,536
Number of Sequences: 1657284
Number of extensions: 11743869
Number of successful extensions: 37916
Number of sequences better than 10.0: 166
Number of HSP's better than 10.0 without gapping: 36484
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 37828
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 42317807226
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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