Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-0177
(773 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 324 1e-87
UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein; ... 310 2e-83
UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular organ... 307 2e-82
UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5; ... 263 3e-69
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 259 6e-68
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 239 7e-62
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 232 8e-60
UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate... 217 2e-55
UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma j... 113 6e-24
UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase... 100 5e-20
UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase... 100 5e-20
UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1; ... 95 2e-18
UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3... 85 2e-15
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 79 9e-14
UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2; ... 79 2e-13
UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4; Eukaryot... 53 7e-06
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 51 3e-05
UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza sa... 43 0.010
UniRef50_A0KSD7 Cluster: Putative uncharacterized protein; n=2; ... 34 4.5
UniRef50_O17998 Cluster: Putative uncharacterized protein; n=2; ... 33 6.0
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 324 bits (797), Expect = 1e-87
Identities = 151/233 (64%), Positives = 179/233 (76%), Gaps = 1/233 (0%)
Frame = +2
Query: 74 RNYGTAKRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQ 253
R + KR+ AKPVVEMDGDEMTRI+W IKE+LI P+V + YFDLGLP+RD TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 254 VTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQ 433
VTIDSA A K++V +KCATITPDE RVEEFKLKKMW SPNGTIRNILGGTVFREPI+C+
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 434 SIPRVVPGWTKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGT-TEXRVLYDFKTP 610
+IPR+VPGWTKPI I RHAHGDQY A DFV + G ++V+T +DG+ + +Y+F
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAG 215
Query: 611 GVAMGMYNTDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQXHFRK 769
GV MGMYNTDESI F H F A+QKKW LY+ST NTILK Y G + F++
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQE 268
>UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein;
n=6; core eudicotyledons|Rep: Isocitrate
dehydrogenase-like protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 485
Score = 310 bits (762), Expect = 2e-83
Identities = 142/230 (61%), Positives = 175/230 (76%), Gaps = 1/230 (0%)
Frame = +2
Query: 83 GTAKRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTI 262
G + R+ P+VEMDGDEMTR++W+ IKE+LI PY+ +D YFDLG+ +RDATDD+VT+
Sbjct: 71 GGSDRIQVQNPIVEMDGDEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTV 130
Query: 263 DSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIP 442
+SA A LK+NV IKCATITPDE RV+EF LK MW SPNGTIRNIL GTVFREPI+C +IP
Sbjct: 131 ESAEAALKYNVAIKCATITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIP 190
Query: 443 RVVPGWTKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTEXRV-LYDFKTPGVA 619
R+VPGW KPI I RHA GDQY A D V+ PGK+++V+ DG + +YDFK PGVA
Sbjct: 191 RLVPGWEKPICIGRHAFGDQYRATDTVIKGPGKLKMVFVPEDGNAPVELDVYDFKGPGVA 250
Query: 620 MGMYNTDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQXHFRK 769
+ MYN DESIR+F S +AL KKW LYLST NTILK+Y G + F++
Sbjct: 251 LAMYNVDESIRAFAESSMAMALTKKWPLYLSTKNTILKKYDGRFKDIFQE 300
>UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular
organisms|Rep: F12P19.10 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 410
Score = 307 bits (753), Expect = 2e-82
Identities = 140/226 (61%), Positives = 172/226 (76%)
Frame = +2
Query: 92 KRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSA 271
+++ A P+VEMDGDEMTR++W IK++LI P+V++D YFDLGLPHRDATDD+VTI+SA
Sbjct: 4 EKIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESA 63
Query: 272 HAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVV 451
A K+NV IKCATITPDE RV EF LK+MW SPNGTIRNIL GTVFREPI+C+++P++V
Sbjct: 64 EATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLV 123
Query: 452 PGWTKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTEXRVLYDFKTPGVAMGMY 631
PGWTKPI I RHA GDQY A D V+ PGK+ + + +DG TE V GVAM MY
Sbjct: 124 PGWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMY 183
Query: 632 NTDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQXHFRK 769
NTDESIR+F S A +KKW LYLST NTILK+Y G + F++
Sbjct: 184 NTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQE 229
>UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5;
Eukaryota|Rep: Putative uncharacterized protein - Oryza
sativa subsp. indica (Rice)
Length = 475
Score = 263 bits (645), Expect = 3e-69
Identities = 132/237 (55%), Positives = 162/237 (68%), Gaps = 18/237 (7%)
Frame = +2
Query: 116 VVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNV 295
V GDEMTR++W IK++LIFP++ +D Y+DLGLP+RDAT D+VTI+SA A LK+NV
Sbjct: 37 VTRNSGDEMTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIESAEATLKYNV 96
Query: 296 GIKCATITP------------------DEQRVEEFKLKKMWLSPNGTIRNILGGTVFREP 421
IKCATITP DE RV+EF L MW SPNGTIRNIL GTVFREP
Sbjct: 97 AIKCATITPVLDTQFKFDFGRTIHEPTDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREP 156
Query: 422 ILCQSIPRVVPGWTKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTEXRVLYDF 601
I+C++IPR+VPGW KPI I RHA GDQY A D V+ PGK++LV+ R+ E V
Sbjct: 157 IICKNIPRLVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKLVFDGREEQIELDVFNFT 216
Query: 602 KTPGVAMGMYNTDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQXHFRKN 772
GVA+ MYNTDESI +F S +A QK+W LYLST NTILK+Y G + F++N
Sbjct: 217 GAGGVALSMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFKDIFQEN 273
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 259 bits (634), Expect = 6e-68
Identities = 122/184 (66%), Positives = 146/184 (79%), Gaps = 1/184 (0%)
Frame = +2
Query: 221 GLPHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILG 400
G+ +RD TDD+VT+++A AI K+ VG+KCATITPDE RVEEFKLKKMWLSPNGTIRNILG
Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160
Query: 401 GTVFREPILCQSIPRVVPGWTKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTE 580
GTVFREPI+ +IPR+VPGWTKPI+I RHA GDQY A D V+P PGK+ELVYT +G E
Sbjct: 161 GTVFREPIVIPAIPRLVPGWTKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGQPE 220
Query: 581 XRVLYDFKT-PGVAMGMYNTDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQX 757
+YDF++ GVAM MYNTD+SIR F H SF +AL K LY+ST NTILKRY G +
Sbjct: 221 SVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNTILKRYDGRFKD 280
Query: 758 HFRK 769
F++
Sbjct: 281 IFQE 284
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 239 bits (584), Expect = 7e-62
Identities = 111/225 (49%), Positives = 150/225 (66%)
Frame = +2
Query: 92 KRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSA 271
+++ P+VEMDGDEMTRI+W IK+ L+ P++ ++ Y+DLGL +R+ TDDQVTID+A
Sbjct: 17 EKIQMTTPLVEMDGDEMTRILWKMIKDELLLPFIDLNTEYYDLGLNYRNETDDQVTIDAA 76
Query: 272 HAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVV 451
A K+ V +KCATITP+ R++E+ LKKM+ SPNGTIR IL GTVFR PI+ + I V
Sbjct: 77 EATKKYGVAVKCATITPNHARMDEYDLKKMYKSPNGTIRAILDGTVFRAPIVVKGIEPCV 136
Query: 452 PGWTKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTEXRVLYDFKTPGVAMGMY 631
W KPI + RHA+GD Y + + KPGKVELVYT+ DG + ++ +FK PGVAMGM+
Sbjct: 137 RNWKKPITLARHAYGDIYKNTEMYIDKPGKVELVYTSEDGEEKRSLVQEFKAPGVAMGMH 196
Query: 632 NTDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQXHFR 766
N SI SF F AL K ++ +TI K Y + F+
Sbjct: 197 NMTASIESFARSCFNYALDTKQDVWFGAKDTISKTYDAKFKEVFQ 241
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 232 bits (567), Expect = 8e-60
Identities = 108/209 (51%), Positives = 146/209 (69%)
Frame = +2
Query: 113 PVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHN 292
P+VEMDGDEMTRI+W IKE L+ PY+ + Y+DLGL R+ T+D++TI++A+AI K+
Sbjct: 10 PLVEMDGDEMTRIIWKMIKELLLEPYIDLKTEYYDLGLVKRNETNDEITIEAANAIKKYG 69
Query: 293 VGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPI 472
VG+KCATITP+ +RV+E+ LK MW SPNGTIR IL GTVFR PI+ SI ++ W KPI
Sbjct: 70 VGVKCATITPNAKRVKEYNLKSMWKSPNGTIRAILDGTVFRTPIIVNSIRPLMRTWEKPI 129
Query: 473 VIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTEXRVLYDFKTPGVAMGMYNTDESIR 652
+ RHA+GD Y ++ V +PGK+ELV+T+ G + L+ F PGV MGM+N D+SI
Sbjct: 130 TVARHAYGDVYRDVEYKVEEPGKMELVFTSEKGEETRQTLHVFNGPGVVMGMHNLDKSIE 189
Query: 653 SFXHXSFXVALQKKWXLYLSTXNTILKRY 739
SF F AL L+ ++ +TI K Y
Sbjct: 190 SFARSCFNYALDMNQNLWFASKDTISKTY 218
>UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 1 (NADP+), soluble; n=2; Danio rerio|Rep:
PREDICTED: similar to Isocitrate dehydrogenase 1
(NADP+), soluble - Danio rerio
Length = 206
Score = 217 bits (531), Expect = 2e-55
Identities = 94/134 (70%), Positives = 118/134 (88%)
Frame = +2
Query: 101 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAI 280
+ A VVEM GDEMTR++W IKE+LIFPY+++D +DLG+ +RDATDD+VT+++A A+
Sbjct: 12 IKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAV 71
Query: 281 LKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGW 460
++NVGIKCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTVFRE I+C++IPR+VPGW
Sbjct: 72 RRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGW 131
Query: 461 TKPIVIXRHAHGDQ 502
KPI+I RHAHGDQ
Sbjct: 132 IKPIIIGRHAHGDQ 145
>UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC09598 protein - Schistosoma
japonicum (Blood fluke)
Length = 129
Score = 113 bits (271), Expect = 6e-24
Identities = 59/87 (67%), Positives = 66/87 (75%)
Frame = -3
Query: 423 IGSRNTVPPKMLRIVPFGLSHIFFNLNSSTLCSSGVIVAHLMPTLCFRMACAESMVT*SS 244
+GSR TVPP++LRIVPFG SHIFF LNS T CSSGV+VAHL+PTL F +A A S+VT S
Sbjct: 1 MGSRKTVPPRILRIVPFGDSHIFFKLNSLTRCSSGVMVAHLIPTLYFLIASAPSIVTWSL 60
Query: 243 VASRCGRPKSK*RQSTLTYGNISLSLI 163
V SR GRPKSK QST GNIS I
Sbjct: 61 VRSRLGRPKSKYLQSTSINGNISCCFI 87
>UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: NADP-dependent
isocitrate dehydrogenase protein - Rhizobium etli
(strain CFN 42 / ATCC 51251)
Length = 437
Score = 100 bits (239), Expect = 5e-20
Identities = 66/216 (30%), Positives = 106/216 (49%)
Frame = -2
Query: 769 FSKMXLXRPMVTFQNGIXRRQV*XPFFL*SYXKTXMXKGPNRFVGIVHAHSNARSFKII* 590
F + L ++ ++G+ RQV PF + + +RFV +VH H NA + ++
Sbjct: 196 FLEDVLEAAVIGLEDGVLGRQVDRPFAHQAVHHRGAGEFADRFVEVVHGHGNAGARRVED 255
Query: 589 YTXLCRTISCSVNKFNLSGFRYNKILRXVLVAVRMTAYHNRFRPTRHNPRDTLTQYRFAE 410
+ L+ ++ VLVA +TA +R RP + R+ R AE
Sbjct: 256 LLLDDGAVFTDELDRQLALAGELEVGCAVLVAESVTADDDRLRPAGNEARNVAADDRLAE 315
Query: 409 YCTAQNVTDRSVRA*PHFLQLELFYSLFIRCDSSAFDAHIML*NGMR*VDGDLIISGVTM 230
A+NV+DR+VRA PHFL++E + FIR D A D + +G+ VD L++ GV +
Sbjct: 316 DDAAENVSDRAVRALPHFLEIEFLDAGFIRRDRCALDTDAVFLDGVGGVDRHLVVGGVAI 375
Query: 229 REAQVKVKTIHLNIWKYQSLFDLSPHDACHLITIHL 122
+ +V + I + I Q + D P DACH I + +
Sbjct: 376 FDREVVIVDIEVEIRMDQLILDELPDDACHFIAVEI 411
>UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=2; Rhodobacteraceae|Rep: NADP-dependent
isocitrate dehydrogenase protein - Sagittula stellata
E-37
Length = 459
Score = 100 bits (239), Expect = 5e-20
Identities = 67/211 (31%), Positives = 100/211 (47%)
Frame = -2
Query: 754 LXRPMVTFQNGIXRRQV*XPFFL*SYXKTXMXKGPNRFVGIVHAHSNARSFKII*YTXLC 575
L P+V +NG+ RQV P + + K +R V +VHAH + +++
Sbjct: 232 LEPPVVGLENGVLGRQVHRPAQRQTVVQRGAGKVADRLVLVVHAHVDPGIGRVVDLALDH 291
Query: 574 RTISCSVNKFNLSGFRYNKILRXVLVAVRMTAYHNRFRPTRHNPRDTLTQYRFAEYCTAQ 395
+ L+ +I VLVA + A+H+ P RH R R AE AQ
Sbjct: 292 LAVGAFPFHRQLARRGEVEIRGLVLVAEGVPAHHDGRGPARHEARHVAADDRLAEDDAAQ 351
Query: 394 NVTDRSVRA*PHFLQLELFYSLFIRCDSSAFDAHIML*NGMR*VDGDLIISGVTMREAQV 215
+V DR+V PH L+ E +L +R D AFD L VDGDL+ V + + ++
Sbjct: 352 DVADRAVGRLPHLLETEFLDTLLVRGDRRAFDRDANLLRLFGGVDGDLVPGPVPLLDPEI 411
Query: 214 KVKTIHLNIWKYQSLFDLSPHDACHLITIHL 122
VK + + + + Q D SPHDA HL+ +HL
Sbjct: 412 VVKQVQVEVRQDQLFLDESPHDAGHLVAVHL 442
>UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 141
Score = 94.7 bits (225), Expect = 2e-18
Identities = 55/91 (60%), Positives = 63/91 (69%)
Frame = -3
Query: 393 MLRIVPFGLSHIFFNLNSSTLCSSGVIVAHLMPTLCFRMACAESMVT*SSVASRCGRPKS 214
MLRIVP G HIF +LNS T SS VIVAHL+PTLC R+A A S VT S VASR +S
Sbjct: 1 MLRIVPLGEGHIFLSLNSLTRASSAVIVAHLIPTLCSRIAQAASKVTQSLVASRFSIERS 60
Query: 213 K*RQSTLTYGNISLSLILAHMMRVISSPSIS 121
+ S GN+SLSLI+ M+RVISSPS S
Sbjct: 61 QYLISAEINGNMSLSLIIFQMIRVISSPSKS 91
>UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3;
Ostreococcus|Rep: COG0538: Isocitrate dehydrogenases -
Ostreococcus tauri
Length = 429
Score = 85.0 bits (201), Expect = 2e-15
Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 7/223 (3%)
Frame = +2
Query: 86 TAKRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLY-FDLGLPHRDATDDQVTI 262
TA + A P+V + G+EMT + I+ R I P V V FDL +RD T+D+V
Sbjct: 21 TASSKITAAPMVYVRGEEMTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLR 80
Query: 263 DSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGG-TVFREPILCQSI 439
D A + K T+TP +V+ L+K W SPNG +R G T+ R+ I I
Sbjct: 81 DVIEAGKRIKAIFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTI---HI 137
Query: 440 PRVVPGWTKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTEXR-VLYDFK---- 604
V G+ KP++ RHA G +Y A V K GK+ +T +G + V+ D +
Sbjct: 138 DGVELGYKKPVLFERHAVGGEYSAGYKNVGK-GKLTTTFTPSEGPDAGKTVVVDEREIVD 196
Query: 605 TPGVAMGMYNTDESIRSFXHXSFXVALQKKWXLYLSTXNTILK 733
+ +N +++ F L+ K Y+ T T+ K
Sbjct: 197 EEAAVVTYHNPYDNVHDLARFFFGRCLEAKVTPYVVTKKTVFK 239
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 79.4 bits (187), Expect = 9e-14
Identities = 55/229 (24%), Positives = 106/229 (46%), Gaps = 12/229 (5%)
Frame = +2
Query: 95 RVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAH 274
++ P+V + GDEM ++ + +I ++ + + ++ + DL HR T+ QV ++
Sbjct: 4 KIQVESPLVILHGDEMAQVAFEEILKKFVTTRLAIELIEIDLSAEHRFLTNGQVIFEAIE 63
Query: 275 AILKHNVGIKCATITPDEQRVEEFKLKKMWL-----------SPNGTIRNILGGTVFREP 421
A+ K+ VG+K A +T + ++++ K L SPNG IR +GG + RE
Sbjct: 64 ALKKYGVGVKNAGMTVNREQLDAMLEKHPELSQSRLDPLATKSPNGAIRKGIGGNITRED 123
Query: 422 ILCQSIPRVVPGW-TKPIVIXRHAHGDQYXAQDFVVPKPGKVELVYTTRDGTTEXRVLYD 598
I Q++ P W + I + +G + + + G V+L++ + G D
Sbjct: 124 IQFQNLRVRKPDWIDRDIDVDTMDNGGIKDSYNELSSSTGVVKLLFVGKSGNPVELHRRD 183
Query: 599 FKTPGVAMGMYNTDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHG 745
K + N ++++ H F A+ +K YL +T++ Y G
Sbjct: 184 VKKGDPWLLATNDIADVKAWAHRFFQRAIDEKRDAYLGLKDTVIAGYDG 232
>UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 371
Score = 78.6 bits (185), Expect = 2e-13
Identities = 38/77 (49%), Positives = 50/77 (64%), Gaps = 1/77 (1%)
Frame = +2
Query: 542 VELVYTTRDGTTEXRV-LYDFKTPGVAMGMYNTDESIRSFXHXSFXVALQKKWXLYLSTX 718
V + + DG + +Y+FK PGVA+ MYN DESIR+F S +AL KKW LYLST
Sbjct: 27 VPRILSVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWPLYLSTK 86
Query: 719 NTILKRYHGSXQXHFRK 769
NTILK+Y G + F++
Sbjct: 87 NTILKKYDGRFKDIFQE 103
Score = 62.9 bits (146), Expect = 9e-09
Identities = 27/40 (67%), Positives = 33/40 (82%), Gaps = 2/40 (5%)
Frame = +2
Query: 359 MWLSPNGTIRNILGGTVFREPILCQSIPRV--VPGWTKPI 472
MW SPNGTIRNIL GTVFREPILC+++PR+ VP +P+
Sbjct: 1 MWRSPNGTIRNILNGTVFREPILCKNVPRILSVPDGAEPV 40
Score = 50.8 bits (116), Expect = 4e-05
Identities = 23/43 (53%), Positives = 30/43 (69%)
Frame = +2
Query: 641 ESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQXHFRK 769
+SIR+F S +AL KKW LYLST NTILK+Y G + F++
Sbjct: 157 QSIRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFKDIFQE 199
>UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4;
Eukaryota|Rep: Isocitrate dehydrogenase - Saltugilia
latimeri
Length = 158
Score = 53.2 bits (122), Expect = 7e-06
Identities = 25/45 (55%), Positives = 30/45 (66%)
Frame = +2
Query: 635 TDESIRSFXHXSFXVALQKKWXLYLSTXNTILKRYHGSXQXHFRK 769
TDESI SF S A +KKW LYLST NTILK+Y G + F++
Sbjct: 1 TDESIYSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQE 45
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 51.2 bits (117), Expect = 3e-05
Identities = 42/138 (30%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Frame = +2
Query: 116 VVEMDGDEMTRIMWAKIKERLIFPYV---KVDCLYFDLGLPHRDATDDQVTIDSAHAILK 286
+V ++GD+ + + + RL+ P V + + +DL L +R AT ++V ++A A+ +
Sbjct: 7 IVVLEGDQTGQELLEEAV-RLLSPDVIGLPLHLVRYDLSLENRRATSNRVVYEAAAAMRE 65
Query: 287 HNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTK 466
H G+K ATITP E R + SPN +R + GTV + G T
Sbjct: 66 HGYGLKAATITP-EGRGDVG-------SPNAILRREIDGTVILRTGRPLPGVETIGGITA 117
Query: 467 PIVIXRHAHGDQYXAQDF 520
PI + R A D Y A+++
Sbjct: 118 PIAVVRMATEDAYEAKEW 135
>UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza
sativa|Rep: Isocitrate dehydrogenase - Oryza sativa
(Rice)
Length = 61
Score = 42.7 bits (96), Expect = 0.010
Identities = 16/25 (64%), Positives = 21/25 (84%)
Frame = +2
Query: 128 DGDEMTRIMWAKIKERLIFPYVKVD 202
DGDEMTRI W IK++LIFP++ +D
Sbjct: 35 DGDEMTRIFWQSIKDKLIFPFLDLD 59
>UniRef50_A0KSD7 Cluster: Putative uncharacterized protein; n=2;
Proteobacteria|Rep: Putative uncharacterized protein -
Shewanella sp. (strain ANA-3)
Length = 112
Score = 33.9 bits (74), Expect = 4.5
Identities = 15/52 (28%), Positives = 27/52 (51%)
Frame = +2
Query: 314 ITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKP 469
+T ++ VEE +++MW+ G I NI G + +P + I + W +P
Sbjct: 53 VTENDAGVEEVNVERMWVIVKGRIDNIYRGQLDNDPYCTEEIRSGMEVWFQP 104
>UniRef50_O17998 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 312
Score = 33.5 bits (73), Expect = 6.0
Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Frame = +2
Query: 122 EMDGDEMTRIM-WAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNVG 298
EMD D +T++ W +IK LI ++ L L LP T +TI + + KH +G
Sbjct: 170 EMDCDGLTKLPHWKRIKSLLIEGFIVSAPLEHFLHLPEVTITMQSITIFNLKLLKKHFLG 229
Query: 299 IK 304
+K
Sbjct: 230 LK 231
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 743,082,466
Number of Sequences: 1657284
Number of extensions: 14471496
Number of successful extensions: 30485
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 29694
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 30474
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 65027411410
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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