Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-0092
(700 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_O96660 Cluster: CG2262-PA; n=6; Diptera|Rep: CG2262-PA ... 140 2e-32
UniRef50_Q15796 Cluster: Mothers against decapentaplegic homolog... 125 9e-31
UniRef50_Q4T274 Cluster: Chromosome undetermined SCAF10323, whol... 119 6e-30
UniRef50_Q9JIW5 Cluster: Mothers against decapentaplegic homolog... 130 2e-29
UniRef50_Q9NH63 Cluster: TGF-beta signal transducer Smad2; n=4; ... 130 4e-29
UniRef50_O15198 Cluster: Mothers against decapentaplegic homolog... 129 7e-29
UniRef50_UPI000065F60D Cluster: Mothers against decapentaplegic ... 122 8e-27
UniRef50_A4VC64 Cluster: Smad1B; n=2; Schistosoma|Rep: Smad1B - ... 120 3e-26
UniRef50_Q4SLW9 Cluster: Chromosome 13 SCAF14555, whole genome s... 120 3e-26
UniRef50_Q02330 Cluster: Dwarfin sma-2; n=2; Caenorhabditis|Rep:... 106 5e-22
UniRef50_Q4SJG4 Cluster: Chromosome 4 SCAF14575, whole genome sh... 100 7e-20
UniRef50_UPI000065E7B0 Cluster: Mothers against decapentaplegic ... 97 3e-19
UniRef50_A7SY32 Cluster: Predicted protein; n=2; Nematostella ve... 97 4e-19
UniRef50_Q13485 Cluster: Mothers against decapentaplegic homolog... 97 5e-19
UniRef50_Q90Y94 Cluster: Smad4 type4; n=3; Cyprinidae|Rep: Smad4... 95 2e-18
UniRef50_UPI00015B52EA Cluster: PREDICTED: similar to smad4; n=1... 94 3e-18
UniRef50_O76259 Cluster: MEDEA; n=11; Diptera|Rep: MEDEA - Droso... 93 6e-18
UniRef50_Q4H2T4 Cluster: Smad4; n=11; Chordata|Rep: Smad4 - Cion... 92 1e-17
UniRef50_Q4T9H5 Cluster: Chromosome 12 SCAF7567, whole genome sh... 92 1e-17
UniRef50_Q4H2T6 Cluster: Smad2/3a; n=2; Chordata|Rep: Smad2/3a -... 91 2e-17
UniRef50_Q95QI7 Cluster: Abnormal dauer formation protein 3, iso... 91 2e-17
UniRef50_P45896 Cluster: Dwarfin sma-3; n=2; Caenorhabditis|Rep:... 89 1e-16
UniRef50_Q4T1H9 Cluster: Chromosome undetermined SCAF10575, whol... 89 1e-16
UniRef50_Q27W07 Cluster: Smad4; n=2; Nematostella vectensis|Rep:... 87 5e-16
UniRef50_Q6UEH7 Cluster: Smad4; n=3; Eumetazoa|Rep: Smad4 - Schi... 86 9e-16
UniRef50_UPI00006A24FD Cluster: UPI00006A24FD related cluster; n... 83 5e-15
UniRef50_Q5WN84 Cluster: Putative uncharacterized protein CBG081... 81 3e-14
UniRef50_Q14QT5 Cluster: TGF-beta signal transducer SmadD; n=1; ... 71 4e-11
UniRef50_P45897 Cluster: Dwarfin sma-4; n=4; Caenorhabditis|Rep:... 69 8e-11
UniRef50_Q4SHL4 Cluster: Chromosome 5 SCAF14581, whole genome sh... 59 9e-08
UniRef50_Q9W734 Cluster: Mothers against decapentaplegic homolog... 57 4e-07
UniRef50_UPI000065CB05 Cluster: Mothers against decapentaplegic ... 56 8e-07
UniRef50_O43541 Cluster: Mothers against decapentaplegic homolog... 55 1e-06
UniRef50_UPI0000E4A165 Cluster: PREDICTED: similar to inhibitory... 54 3e-06
UniRef50_UPI0000D554E6 Cluster: PREDICTED: similar to Mothers ag... 54 3e-06
UniRef50_UPI0000DB6F46 Cluster: PREDICTED: similar to Mothers ag... 54 3e-06
UniRef50_Q21733 Cluster: Putative uncharacterized protein daf-8;... 50 4e-05
UniRef50_UPI00006A24F3 Cluster: UPI00006A24F3 related cluster; n... 50 5e-05
UniRef50_A7S9K9 Cluster: Predicted protein; n=1; Nematostella ve... 48 2e-04
UniRef50_Q4H2T3 Cluster: Smad6/7; n=2; Ascidiacea|Rep: Smad6/7 -... 48 3e-04
UniRef50_Q70MW2 Cluster: Inhibitory SMAD; n=1; Crassostrea gigas... 47 4e-04
UniRef50_Q8AWR7 Cluster: Smad7; n=15; Euteleostomi|Rep: Smad7 - ... 46 0.001
UniRef50_Q61DE5 Cluster: Putative uncharacterized protein CBG125... 45 0.002
UniRef50_O15105 Cluster: Mothers against decapentaplegic homolog... 43 0.008
UniRef50_UPI000069FAC8 Cluster: Mothers against decapentaplegic ... 42 0.011
UniRef50_UPI00015B5D64 Cluster: PREDICTED: similar to LD41184p; ... 36 1.3
UniRef50_Q9N638 Cluster: Putative uncharacterized protein tag-68... 36 1.3
UniRef50_UPI0000D65DF2 Cluster: PREDICTED: similar to SMAD8 prot... 35 1.7
UniRef50_Q5C800 Cluster: Putative uncharacterized protein; n=1; ... 34 2.9
UniRef50_Q9VPL9 Cluster: CG3696-PA, isoform A; n=12; Diptera|Rep... 34 3.9
UniRef50_A0DE90 Cluster: Chromosome undetermined scaffold_47, wh... 34 3.9
UniRef50_Q6UED9 Cluster: Phox2a splice variant 2; n=1; Xenopus l... 33 5.1
UniRef50_A0QYG7 Cluster: Putative uncharacterized protein; n=1; ... 33 5.1
UniRef50_Q2R140 Cluster: Retrotransposon protein, putative, uncl... 33 5.1
UniRef50_A4H970 Cluster: 5'-3' exonuclease, putative; n=1; Leish... 33 5.1
UniRef50_A7EFQ6 Cluster: Predicted protein; n=1; Sclerotinia scl... 33 6.7
UniRef50_Q5XJS1 Cluster: Zgc:101624; n=2; Danio rerio|Rep: Zgc:1... 33 8.9
>UniRef50_O96660 Cluster: CG2262-PA; n=6; Diptera|Rep: CG2262-PA -
Drosophila melanogaster (Fruit fly)
Length = 486
Score = 140 bits (340), Expect = 2e-32
Identities = 59/88 (67%), Positives = 72/88 (81%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC 180
ERAIS+QN T+CVT+PR KP +G + RKGLPHV+YCRLWRWP LQSQ+ELKP+DHC
Sbjct: 50 ERAISTQNCQTRCVTVPRSKPAPAGEH--LRKGLPHVIYCRLWRWPDLQSQNELKPLDHC 107
Query: 181 EYAYQLKKDEVCINPYHYNKIDSPALPP 264
EYA+ L+K+E+CINPYHY KI+ L P
Sbjct: 108 EYAFHLRKEEICINPYHYKKIELSILVP 135
Score = 55.6 bits (128), Expect = 1e-06
Identities = 24/40 (60%), Positives = 32/40 (80%)
Frame = +1
Query: 475 GYISEDGDPMDHNDNMNLTRLSPSPGGLXXEASPVLYHEP 594
GY+SEDGDP+D NDNMN++RL+P +A+PV+YHEP
Sbjct: 256 GYMSEDGDPIDPNDNMNMSRLTP-----PADAAPVMYHEP 290
Score = 41.1 bits (92), Expect = 0.025
Identities = 16/16 (100%), Positives = 16/16 (100%)
Frame = +2
Query: 593 PAFWCSISYYELNTRV 640
PAFWCSISYYELNTRV
Sbjct: 290 PAFWCSISYYELNTRV 305
Score = 36.3 bits (80), Expect = 0.72
Identities = 15/18 (83%), Positives = 15/18 (83%)
Frame = +3
Query: 645 ETFHAXXPFITVDGFTDP 698
ETFHA P ITVDGFTDP
Sbjct: 307 ETFHASQPSITVDGFTDP 324
>UniRef50_Q15796 Cluster: Mothers against decapentaplegic homolog 2;
n=147; Eumetazoa|Rep: Mothers against decapentaplegic
homolog 2 - Homo sapiens (Human)
Length = 467
Score = 125 bits (302), Expect(2) = 9e-31
Identities = 73/178 (41%), Positives = 95/178 (53%), Gaps = 9/178 (5%)
Frame = +1
Query: 88 YRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPPI 267
+RKGLPHV+YCRLWRWP L S HELK +++CEYA+ LKKDEVC+NPYHY ++++P LPP+
Sbjct: 119 HRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPV 178
Query: 268 LVRRCSEGEVRAPPPYADYHQPILHEHPD-VAMQSGTGHSALYLEATLAQHVPGNXXXXX 444
LV R +E + PP DY H P+ +G + Y+ T
Sbjct: 179 LVPRHTE-ILTELPPLDDY----THSIPENTNFPAGIEPQSNYIPET------------- 220
Query: 445 XXXXXXXXXXGYISEDGDPMDHNDNMNL-----TRLSP---SPGGLXXEASPVLYHEP 594
GYISEDG+ D N ++ LSP SP + PV Y EP
Sbjct: 221 -------PPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEP 271
Score = 37.9 bits (84), Expect = 0.24
Identities = 14/18 (77%), Positives = 16/18 (88%)
Frame = +2
Query: 587 TSPAFWCSISYYELNTRV 640
+ PAFWCSI+YYELN RV
Sbjct: 269 SEPAFWCSIAYYELNQRV 286
Score = 35.5 bits (78), Expect = 1.3
Identities = 14/18 (77%), Positives = 15/18 (83%)
Frame = +3
Query: 645 ETFHAXXPFITVDGFTDP 698
ETFHA P +TVDGFTDP
Sbjct: 288 ETFHASQPSLTVDGFTDP 305
Score = 31.1 bits (67), Expect(2) = 9e-31
Identities = 12/17 (70%), Positives = 16/17 (94%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIP 51
E+AI++QN +TKCVTIP
Sbjct: 62 EKAITTQNCNTKCVTIP 78
>UniRef50_Q4T274 Cluster: Chromosome undetermined SCAF10323, whole
genome shotgun sequence; n=9; Euteleostomi|Rep:
Chromosome undetermined SCAF10323, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 552
Score = 119 bits (287), Expect(2) = 6e-30
Identities = 70/177 (39%), Positives = 91/177 (51%), Gaps = 8/177 (4%)
Frame = +1
Query: 88 YRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPPI 267
+RKGLPHV YCRLWRWP L S HELK +D C+YA+ LKKDEVC+NPYHY ++++P LPP+
Sbjct: 126 HRKGLPHVFYCRLWRWPDLHSHHELKAIDACQYAFNLKKDEVCVNPYHYQRVETPVLPPV 185
Query: 268 LVRRCSEGEVRAPPPYADYHQPILHEHPDVAMQSGTGHSALYLEATLAQHVPGNXXXXXX 447
LV R E+ P+ D + E+ + +G Y+ T
Sbjct: 186 LVPR--HTEILTELPHLDDFTNSIPENTN--FPAGIDPPNNYIPET-------------- 227
Query: 448 XXXXXXXXXGYISEDGDPMDHNDNMNLTRLSP---SPGGL-----XXEASPVLYHEP 594
GYISEDG+ D N ++ SP SP L + PV Y EP
Sbjct: 228 ------PPPGYISEDGETSDQQMNQSMETGSPAEMSPSSLSPVSHGLDLQPVTYSEP 278
Score = 37.9 bits (84), Expect = 0.24
Identities = 14/18 (77%), Positives = 16/18 (88%)
Frame = +2
Query: 587 TSPAFWCSISYYELNTRV 640
+ PAFWCSI+YYELN RV
Sbjct: 276 SEPAFWCSIAYYELNQRV 293
Score = 35.5 bits (78), Expect = 1.3
Identities = 14/18 (77%), Positives = 15/18 (83%)
Frame = +3
Query: 645 ETFHAXXPFITVDGFTDP 698
ETFHA P +TVDGFTDP
Sbjct: 295 ETFHASQPSLTVDGFTDP 312
Score = 34.3 bits (75), Expect(2) = 6e-30
Identities = 14/17 (82%), Positives = 17/17 (100%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIP 51
E+AIS+QNS+TKCVTIP
Sbjct: 69 EKAISTQNSNTKCVTIP 85
>UniRef50_Q9JIW5 Cluster: Mothers against decapentaplegic homolog 9;
n=46; Bilateria|Rep: Mothers against decapentaplegic
homolog 9 - Mus musculus (Mouse)
Length = 430
Score = 130 bits (315), Expect = 2e-29
Identities = 67/172 (38%), Positives = 90/172 (52%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC 180
ERA+S +KCVTIPR ++ +RKGLPHV+YCR+WRWP LQS HELKP++ C
Sbjct: 56 ERALSCPGQPSKCVTIPRSLDGRLQVS--HRKGLPHVIYCRVWRWPDLQSHHELKPLECC 113
Query: 181 EYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYADYHQPILHEHPDVA 360
E+ + K+ EVCINPYHY ++++P LPP+LV R SE + A + LH P +
Sbjct: 114 EFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQL-SLLAKFRSASLHSEPLMP 172
Query: 361 MQSGTGHSALYLEATLAQHVPGNXXXXXXXXXXXXXXXGYISEDGDPMDHND 516
+ S PG+ G SE P H+D
Sbjct: 173 HNATYPDSFQQSLCPAPPSSPGHVFPQSPCPTSYPHSPGSPSESDSPYQHSD 224
Score = 35.1 bits (77), Expect = 1.7
Identities = 12/20 (60%), Positives = 14/20 (70%)
Frame = +2
Query: 581 CTTSPAFWCSISYYELNTRV 640
C P WCS++YYELN RV
Sbjct: 229 CYEEPQHWCSVAYYELNNRV 248
>UniRef50_Q9NH63 Cluster: TGF-beta signal transducer Smad2; n=4;
Schistosoma|Rep: TGF-beta signal transducer Smad2 -
Schistosoma mansoni (Blood fluke)
Length = 649
Score = 130 bits (313), Expect = 4e-29
Identities = 54/93 (58%), Positives = 71/93 (76%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC 180
ERA+ SQ+ T+CVTIPR + + +KGLPHV YC+LWRWP L +QHEL+P+ C
Sbjct: 50 ERALVSQDPSTRCVTIPRSL--DGRLQVAQKKGLPHVFYCQLWRWPDLHTQHELRPIATC 107
Query: 181 EYAYQLKKDEVCINPYHYNKIDSPALPPILVRR 279
EY++Q K+DEVCINPYHY +I++P LPPI+V R
Sbjct: 108 EYSFQSKRDEVCINPYHYRRIENPVLPPIMVPR 140
Score = 34.3 bits (75), Expect = 2.9
Identities = 13/19 (68%), Positives = 16/19 (84%)
Frame = +2
Query: 593 PAFWCSISYYELNTRVXGD 649
P +WCS+ YYE+NTRV GD
Sbjct: 453 PEYWCSLYYYEMNTRV-GD 470
Score = 32.7 bits (71), Expect = 8.9
Identities = 12/18 (66%), Positives = 14/18 (77%)
Frame = +3
Query: 645 ETFHAXXPFITVDGFTDP 698
+TFH P +TVDGFTDP
Sbjct: 470 DTFHCSSPCLTVDGFTDP 487
>UniRef50_O15198 Cluster: Mothers against decapentaplegic homolog 9;
n=127; Coelomata|Rep: Mothers against decapentaplegic
homolog 9 - Homo sapiens (Human)
Length = 467
Score = 129 bits (311), Expect = 7e-29
Identities = 58/117 (49%), Positives = 77/117 (65%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC 180
ERA+S +KCVTIPR ++ +RKGLPHV+YCR+WRWP LQS HELKP++ C
Sbjct: 56 ERALSCPGQPSKCVTIPRSLDGRLQVS--HRKGLPHVIYCRVWRWPDLQSHHELKPLECC 113
Query: 181 EYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYADYHQPILHEHP 351
E+ + K+ EVCINPYHY ++++P LPP+LV R SE + A + LH P
Sbjct: 114 EFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQL-SLLAKFRSASLHSEP 169
Score = 35.1 bits (77), Expect = 1.7
Identities = 12/20 (60%), Positives = 14/20 (70%)
Frame = +2
Query: 581 CTTSPAFWCSISYYELNTRV 640
C P WCS++YYELN RV
Sbjct: 266 CYEEPQHWCSVAYYELNNRV 285
>UniRef50_UPI000065F60D Cluster: Mothers against decapentaplegic
homolog 9 (SMAD 9) (Mothers against DPP homolog 9)
(Smad9) (Madh6).; n=1; Takifugu rubripes|Rep: Mothers
against decapentaplegic homolog 9 (SMAD 9) (Mothers
against DPP homolog 9) (Smad9) (Madh6). - Takifugu
rubripes
Length = 471
Score = 122 bits (294), Expect = 8e-27
Identities = 50/100 (50%), Positives = 70/100 (70%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC 180
E+A+S +KCVTIPR ++ +RKGLPHV+YCR+WRWP LQS HELK +D C
Sbjct: 50 EKALSCPGQPSKCVTIPRSLDGRLQVS--HRKGLPHVIYCRVWRWPDLQSHHELKALDCC 107
Query: 181 EYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVR 300
E+ + K+ ++C+NPYHY ++++P LPP+LV R E R
Sbjct: 108 EFPFGSKQKDICVNPYHYRRVETPVLPPVLVPRHRGREAR 147
Score = 37.1 bits (82), Expect = 0.41
Identities = 12/20 (60%), Positives = 16/20 (80%)
Frame = +2
Query: 581 CTTSPAFWCSISYYELNTRV 640
C P +WCS++YYELN+RV
Sbjct: 212 CYEEPEYWCSVAYYELNSRV 231
>UniRef50_A4VC64 Cluster: Smad1B; n=2; Schistosoma|Rep: Smad1B -
Schistosoma mansoni (Blood fluke)
Length = 380
Score = 120 bits (290), Expect = 3e-26
Identities = 50/94 (53%), Positives = 67/94 (71%)
Frame = +1
Query: 7 AISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEY 186
A+ N ++CVTIPR + I +RKG PHV+YCR+WRWP LQS HEL+PV++C+
Sbjct: 59 ALLHPNEPSECVTIPRSL--DGRIQVSHRKGFPHVIYCRVWRWPDLQSHHELRPVENCKL 116
Query: 187 AYQLKKDEVCINPYHYNKIDSPALPPILVRRCSE 288
+ K+ EVCINPYHY ++D P LPP+LV R +E
Sbjct: 117 PFSSKETEVCINPYHYTRVDYPVLPPVLVPRHNE 150
Score = 33.1 bits (72), Expect = 6.7
Identities = 10/16 (62%), Positives = 14/16 (87%)
Frame = +2
Query: 593 PAFWCSISYYELNTRV 640
P +WCS+ YYELN+R+
Sbjct: 183 PKYWCSVVYYELNSRI 198
>UniRef50_Q4SLW9 Cluster: Chromosome 13 SCAF14555, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 13 SCAF14555, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 266
Score = 120 bits (289), Expect = 3e-26
Identities = 53/110 (48%), Positives = 73/110 (66%), Gaps = 15/110 (13%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPR---------------VKPNESGINGQYRKGLPHVVYCRLWRW 135
E+AI++QN TKC+TIP V+ + + +RKGLPHV+YCRLWRW
Sbjct: 51 EKAITTQNISTKCLTIPSGLGVGFHKTECLSLLVRSLDGRLQVSHRKGLPHVIYCRLWRW 110
Query: 136 PQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCS 285
P LQS HEL+ +DHCE+A+ KKDEVC+NPYHY ++++P+ P+ R S
Sbjct: 111 PDLQSHHELRALDHCEFAFHTKKDEVCVNPYHYQRVETPSKSPLPPRPSS 160
>UniRef50_Q02330 Cluster: Dwarfin sma-2; n=2; Caenorhabditis|Rep:
Dwarfin sma-2 - Caenorhabditis elegans
Length = 418
Score = 106 bits (255), Expect = 5e-22
Identities = 46/95 (48%), Positives = 64/95 (67%), Gaps = 1/95 (1%)
Frame = +1
Query: 31 TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDE 210
T+CVTIPR I+ +RK LPHV+YCR++RWP LQS HELK ++ C + Y+ + +
Sbjct: 60 TECVTIPRSLDGRLQIS--HRKALPHVIYCRVYRWPDLQSHHELKAIEDCRFCYESGQKD 117
Query: 211 VCINPYHYNKIDSP-ALPPILVRRCSEGEVRAPPP 312
+CINPYHY ++ + LPP+LV R SE + PP
Sbjct: 118 ICINPYHYKRVHATGVLPPVLVPRYSEKPPQEVPP 152
>UniRef50_Q4SJG4 Cluster: Chromosome 4 SCAF14575, whole genome
shotgun sequence; n=2; Coelomata|Rep: Chromosome 4
SCAF14575, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 629
Score = 99.5 bits (237), Expect = 7e-20
Identities = 51/122 (41%), Positives = 70/122 (57%), Gaps = 1/122 (0%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ +H +KCVTI R + G RKG PHVVY RLWRWP L ++ELK V +C+
Sbjct: 57 AITTNGAHPSKCVTIQRTLDGRLQVAG--RKGFPHVVYARLWRWPDLH-KNELKHVKYCQ 113
Query: 184 YAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYADYHQPILHEHPDVAM 363
YA+ LK D VC+NPYHY ++ SP + + S G + Y DY H + +
Sbjct: 114 YAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLSSSGPLLVKDEY-DYDNQQSHSSSESHL 172
Query: 364 QS 369
Q+
Sbjct: 173 QT 174
>UniRef50_UPI000065E7B0 Cluster: Mothers against decapentaplegic
homolog 4 (SMAD 4) (Mothers against DPP homolog 4)
(Deletion target in pancreatic carcinoma 4) (hSMAD4).;
n=1; Takifugu rubripes|Rep: Mothers against
decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP
homolog 4) (Deletion target in pancreatic carcinoma 4)
(hSMAD4). - Takifugu rubripes
Length = 623
Score = 97.5 bits (232), Expect = 3e-19
Identities = 46/96 (47%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ +H +KCVTI R + G RKG PHVVY RLWRWP L ++ELK V +C+
Sbjct: 54 AITTNGAHPSKCVTIQRTLDGRLQVAG--RKGFPHVVYARLWRWPDLH-KNELKHVKYCQ 110
Query: 184 YAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEG 291
YA+ LK D VC+NPYHY ++ SP + + R G
Sbjct: 111 YAFDLKCDSVCVNPYHYERVVSPGIGEVSDSRSLPG 146
>UniRef50_A7SY32 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 401
Score = 97.1 bits (231), Expect = 4e-19
Identities = 44/96 (45%), Positives = 64/96 (66%), Gaps = 1/96 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI+S +H +KCVTI R + G RKG PHV+Y R+WRWP L ++EL+ V +C+
Sbjct: 55 AITSAGTHPSKCVTIQRTLDGRLQVAG--RKGFPHVIYARIWRWPDLH-KNELRHVKYCQ 111
Query: 184 YAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEG 291
+A+ LK D VC+NP+HY ++ SP + + + R SEG
Sbjct: 112 FAFDLKCDSVCVNPFHYERVVSPDIAGLSLSRNSEG 147
>UniRef50_Q13485 Cluster: Mothers against decapentaplegic homolog 4;
n=41; Coelomata|Rep: Mothers against decapentaplegic
homolog 4 - Homo sapiens (Human)
Length = 552
Score = 96.7 bits (230), Expect = 5e-19
Identities = 43/85 (50%), Positives = 58/85 (68%), Gaps = 1/85 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ +H +KCVTI R + G RKG PHV+Y RLWRWP L ++ELK V +C+
Sbjct: 60 AITTNGAHPSKCVTIQRTLDGRLQVAG--RKGFPHVIYARLWRWPDLH-KNELKHVKYCQ 116
Query: 184 YAYQLKKDEVCINPYHYNKIDSPAL 258
YA+ LK D VC+NPYHY ++ SP +
Sbjct: 117 YAFDLKCDSVCVNPYHYERVVSPGI 141
>UniRef50_Q90Y94 Cluster: Smad4 type4; n=3; Cyprinidae|Rep: Smad4
type4 - Cyprinus carpio (Common carp)
Length = 568
Score = 94.7 bits (225), Expect = 2e-18
Identities = 43/85 (50%), Positives = 56/85 (65%), Gaps = 1/85 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ H +KCVTI R + G RKG PHV+Y RLWRWP L ++ELK V C+
Sbjct: 56 AITTNGVHPSKCVTIQRTLDGRLQVAG--RKGFPHVIYARLWRWPDLH-KNELKHVKFCQ 112
Query: 184 YAYQLKKDEVCINPYHYNKIDSPAL 258
YA+ LK D VC+NPYHY ++ SP +
Sbjct: 113 YAFDLKYDNVCVNPYHYERVVSPGI 137
>UniRef50_UPI00015B52EA Cluster: PREDICTED: similar to smad4; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to smad4 -
Nasonia vitripennis
Length = 639
Score = 94.3 bits (224), Expect = 3e-18
Identities = 41/85 (48%), Positives = 58/85 (68%), Gaps = 1/85 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ +H +KCVTI R + G RKG PHV+Y R+WRWP L ++ELK V +C+
Sbjct: 84 AITTNGAHPSKCVTIQRTLDGRLQVAG--RKGFPHVIYARIWRWPDLH-KNELKHVKYCQ 140
Query: 184 YAYQLKKDEVCINPYHYNKIDSPAL 258
+A+ LK D VC+NPYHY ++ SP +
Sbjct: 141 FAFDLKCDSVCVNPYHYERVVSPGI 165
>UniRef50_O76259 Cluster: MEDEA; n=11; Diptera|Rep: MEDEA -
Drosophila melanogaster (Fruit fly)
Length = 771
Score = 93.1 bits (221), Expect = 6e-18
Identities = 41/85 (48%), Positives = 57/85 (67%), Gaps = 1/85 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ +H +KCVTI R + G RKG PHV+Y R+WRWP L ++ELK V +C
Sbjct: 88 AITTNGAHPSKCVTIQRTLDGRLQVAG--RKGFPHVIYARIWRWPDLH-KNELKHVKYCA 144
Query: 184 YAYQLKKDEVCINPYHYNKIDSPAL 258
+A+ LK D VC+NPYHY ++ SP +
Sbjct: 145 FAFDLKCDSVCVNPYHYERVVSPGI 169
>UniRef50_Q4H2T4 Cluster: Smad4; n=11; Chordata|Rep: Smad4 - Ciona
intestinalis (Transparent sea squirt)
Length = 527
Score = 92.3 bits (219), Expect = 1e-17
Identities = 42/85 (49%), Positives = 58/85 (68%), Gaps = 1/85 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ +H +KCVTI R + G RKG PHV+Y RLWRWP L ++ELK + C+
Sbjct: 55 AITTSGAHPSKCVTIQRTLDGRLQVAG--RKGFPHVIYARLWRWPDLH-KNELKHLKVCK 111
Query: 184 YAYQLKKDEVCINPYHYNKIDSPAL 258
+A+ LK D VCINPYHY+++ SP +
Sbjct: 112 FAFDLKCDSVCINPYHYDRVVSPGI 136
>UniRef50_Q4T9H5 Cluster: Chromosome 12 SCAF7567, whole genome
shotgun sequence; n=3; Chordata|Rep: Chromosome 12
SCAF7567, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 603
Score = 91.9 bits (218), Expect = 1e-17
Identities = 41/85 (48%), Positives = 57/85 (67%), Gaps = 1/85 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ +H +KCVTI R + G RKG PHV+Y RLWRWP L ++ELK + C+
Sbjct: 57 AITTNGAHPSKCVTIQRTLDGRLQVAG--RKGFPHVIYARLWRWPDLH-KNELKHIKCCQ 113
Query: 184 YAYQLKKDEVCINPYHYNKIDSPAL 258
+A+ LK D VC+NPYHY ++ SP +
Sbjct: 114 FAFDLKCDYVCVNPYHYERVVSPGI 138
>UniRef50_Q4H2T6 Cluster: Smad2/3a; n=2; Chordata|Rep: Smad2/3a -
Ciona intestinalis (Transparent sea squirt)
Length = 446
Score = 91.5 bits (217), Expect = 2e-17
Identities = 46/108 (42%), Positives = 63/108 (58%), Gaps = 12/108 (11%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPRVK----PNESGI----NGQYRKG----LPHVVYCRLWRWPQL 144
E AI Q TKCVT+ R++ N+ + G+ LPHV CR WRWP L
Sbjct: 50 ESAIKHQTQATKCVTVSRMEWRAMMNQPDVITTSTGETINTNSPVLPHVWACRFWRWPHL 109
Query: 145 QSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSE 288
+S EL+ + C + Y+ E+CI PYHYNKI++PALPP+LV + +E
Sbjct: 110 KSAVELQSLSACSHGYEKNMSEICIQPYHYNKIETPALPPVLVPKSTE 157
Score = 35.9 bits (79), Expect = 0.96
Identities = 13/16 (81%), Positives = 14/16 (87%)
Frame = +2
Query: 593 PAFWCSISYYELNTRV 640
P FWCSISYYE+N RV
Sbjct: 250 PPFWCSISYYEMNLRV 265
Score = 35.5 bits (78), Expect = 1.3
Identities = 14/18 (77%), Positives = 15/18 (83%)
Frame = +3
Query: 645 ETFHAXXPFITVDGFTDP 698
ETFHA P +TVDGFTDP
Sbjct: 267 ETFHASQPSLTVDGFTDP 284
>UniRef50_Q95QI7 Cluster: Abnormal dauer formation protein 3,
isoform a; n=5; Caenorhabditis elegans|Rep: Abnormal
dauer formation protein 3, isoform a - Caenorhabditis
elegans
Length = 892
Score = 91.1 bits (216), Expect = 2e-17
Identities = 41/108 (37%), Positives = 66/108 (61%)
Frame = +1
Query: 10 ISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYA 189
+S +T C+TIPR ++G RKG PHVVY +LWR+ ++ +++E + VDHC++A
Sbjct: 267 LSKGTKYTGCITIPRTLDGRLQVHG--RKGFPHVVYGKLWRFNEM-TKNETRHVDHCKHA 323
Query: 190 YQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYADYHQP 333
+++K D VC+NPYHY + + ++V + PPP+ YH P
Sbjct: 324 FEMKSDMVCVNPYHYEIV----IGTMIVGQRDHDNRDMPPPHQRYHTP 367
>UniRef50_P45896 Cluster: Dwarfin sma-3; n=2; Caenorhabditis|Rep:
Dwarfin sma-3 - Caenorhabditis elegans
Length = 393
Score = 89.0 bits (211), Expect = 1e-16
Identities = 35/86 (40%), Positives = 56/86 (65%), Gaps = 2/86 (2%)
Frame = +1
Query: 1 ERAISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC 180
E +++ ++++C+TI K + + ++KGLPHV+YCR+WRWP + S HEL+ +D C
Sbjct: 53 ECVLANPCTNSRCITI--AKSLDGRLQVSHKKGLPHVIYCRVWRWPDISSPHELRSIDTC 110
Query: 181 EYAYQ--LKKDEVCINPYHYNKIDSP 252
Y Y+ K +CINPYHY ++ P
Sbjct: 111 SYPYESSSKTMYICINPYHYQRLSRP 136
>UniRef50_Q4T1H9 Cluster: Chromosome undetermined SCAF10575, whole
genome shotgun sequence; n=9; Euteleostomi|Rep:
Chromosome undetermined SCAF10575, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 595
Score = 88.6 bits (210), Expect = 1e-16
Identities = 38/74 (51%), Positives = 49/74 (66%)
Frame = +1
Query: 37 CVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVC 216
CVTI R + G RKG PHV+Y RLWRWP L ++ELK V C++A+ LK D VC
Sbjct: 163 CVTIQRTLDGRLQVAG--RKGFPHVIYARLWRWPDLH-KNELKHVKFCQFAFDLKYDSVC 219
Query: 217 INPYHYNKIDSPAL 258
+NPYHY ++ SP +
Sbjct: 220 VNPYHYERVVSPGI 233
>UniRef50_Q27W07 Cluster: Smad4; n=2; Nematostella vectensis|Rep:
Smad4 - Nematostella vectensis
Length = 218
Score = 86.6 bits (205), Expect = 5e-16
Identities = 37/74 (50%), Positives = 48/74 (64%)
Frame = +1
Query: 31 TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDE 210
+KCVTI R + + RKG PHV+Y RLWRWP +Q E+K +D C + Y LK +
Sbjct: 78 SKCVTIQRTL--DGRLQVCERKGFPHVIYARLWRWPDIQKM-EMKHLDFCRFGYDLKYES 134
Query: 211 VCINPYHYNKIDSP 252
VC+NPYHY +I SP
Sbjct: 135 VCVNPYHYERIRSP 148
>UniRef50_Q6UEH7 Cluster: Smad4; n=3; Eumetazoa|Rep: Smad4 -
Schistosoma mansoni (Blood fluke)
Length = 738
Score = 85.8 bits (203), Expect = 9e-16
Identities = 40/83 (48%), Positives = 55/83 (66%), Gaps = 1/83 (1%)
Frame = +1
Query: 7 AISSQNSH-TKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCE 183
AI++ S +KCVTI R I G RK LPH++Y R+WRWP L ++EL+ HC
Sbjct: 78 AITTSGSQPSKCVTIQRTLDGRMQIAG--RKCLPHIIYSRIWRWPDLH-RNELRHSKHCL 134
Query: 184 YAYQLKKDEVCINPYHYNKIDSP 252
+ ++LK+D VCINPYHY ++ SP
Sbjct: 135 FGFELKQDCVCINPYHYERVVSP 157
>UniRef50_UPI00006A24FD Cluster: UPI00006A24FD related cluster; n=1;
Xenopus tropicalis|Rep: UPI00006A24FD UniRef100 entry -
Xenopus tropicalis
Length = 205
Score = 83.4 bits (197), Expect = 5e-15
Identities = 32/56 (57%), Positives = 42/56 (75%)
Frame = +1
Query: 91 RKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPAL 258
RKG PHV+Y RLWRWP L ++ELK V C++A+ LK D VC+NPYHY ++ SP +
Sbjct: 3 RKGFPHVIYARLWRWPDLH-KNELKHVKFCQFAFDLKYDSVCVNPYHYERVVSPGI 57
>UniRef50_Q5WN84 Cluster: Putative uncharacterized protein CBG08108;
n=1; Caenorhabditis briggsae|Rep: Putative
uncharacterized protein CBG08108 - Caenorhabditis
briggsae
Length = 880
Score = 80.6 bits (190), Expect = 3e-14
Identities = 32/66 (48%), Positives = 49/66 (74%)
Frame = +1
Query: 37 CVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVC 216
C+TIPR ++G +KG PHVVY +LWR+ ++ S++E + VDHC++A+++K D VC
Sbjct: 264 CITIPRTLDGRLQVHG--KKGFPHVVYGKLWRYSEM-SKNETRHVDHCKHAFEMKTDAVC 320
Query: 217 INPYHY 234
+NPYHY
Sbjct: 321 VNPYHY 326
>UniRef50_Q14QT5 Cluster: TGF-beta signal transducer SmadD; n=1;
Echinococcus multilocularis|Rep: TGF-beta signal
transducer SmadD - Echinococcus multilocularis
Length = 719
Score = 70.5 bits (165), Expect = 4e-11
Identities = 34/82 (41%), Positives = 45/82 (54%)
Frame = +1
Query: 13 SSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAY 192
S+ + T CVTI R + I G RK PH++Y RLWRW EL+ + C + +
Sbjct: 99 SNGATQTSCVTIQRTLDSRMQIAG--RKCFPHLIYARLWRWSDAHKT-ELRHLPFCHFGF 155
Query: 193 QLKKDEVCINPYHYNKIDSPAL 258
K D VC+NPYHY + S AL
Sbjct: 156 DKKLDWVCVNPYHYERTVSSAL 177
>UniRef50_P45897 Cluster: Dwarfin sma-4; n=4; Caenorhabditis|Rep:
Dwarfin sma-4 - Caenorhabditis elegans
Length = 570
Score = 69.3 bits (162), Expect = 8e-11
Identities = 34/79 (43%), Positives = 48/79 (60%)
Frame = +1
Query: 13 SSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAY 192
S+ T CVTI R + G RKG+PHVVY R+WRWP++ S++EL + C+ +
Sbjct: 195 SNGKQPTGCVTIQRSLDGRLQVAG--RKGVPHVVYARIWRWPKV-SKNELVKLVQCQTSS 251
Query: 193 QLKKDEVCINPYHYNKIDS 249
D +CINPYHY ++ S
Sbjct: 252 D-HPDNICINPYHYERVVS 269
>UniRef50_Q4SHL4 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 5 SCAF14581, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 519
Score = 59.3 bits (137), Expect = 9e-08
Identities = 34/108 (31%), Positives = 53/108 (49%), Gaps = 6/108 (5%)
Frame = +1
Query: 91 RKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSP-ALPPI 267
R+ P + CR++RW L LK + HC+ ++ +VC NPYHY+++ P + PP
Sbjct: 182 RRVSPQYLLCRMYRWSDLPVSARLKRLCHCQSFGSVENTDVCCNPYHYSRLCGPESPPPP 241
Query: 268 LVRRCSEGEVRAPP--PYADYHQPILHEHPDVAMQSGT---GHSALYL 396
CS+ P P A P+L P V + T G+S L++
Sbjct: 242 CTLSCSDEHKPLEPNQPRAGRPPPLLPSAPHVTPRDYTDDQGNSLLHI 289
>UniRef50_Q9W734 Cluster: Mothers against decapentaplegic homolog 6;
n=19; Euteleostomi|Rep: Mothers against decapentaplegic
homolog 6 - Gallus gallus (Chicken)
Length = 431
Score = 57.2 bits (132), Expect = 4e-07
Identities = 27/80 (33%), Positives = 41/80 (51%)
Frame = +1
Query: 82 GQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALP 261
G R+ PH++ +L+RWP LQ ELK + C+ VC NPYH++++ P P
Sbjct: 150 GAARRPPPHLLLGKLFRWPDLQHPAELKALCECQSFGAADGPTVCCNPYHFSRLCGPESP 209
Query: 262 PILVRRCSEGEVRAPPPYAD 321
P R S + + P +D
Sbjct: 210 PPPYSRLSPNDEQKPLDLSD 229
>UniRef50_UPI000065CB05 Cluster: Mothers against decapentaplegic
homolog 6 (SMAD 6) (Mothers against DPP homolog 6)
(Smad6) (hSMAD6).; n=1; Takifugu rubripes|Rep: Mothers
against decapentaplegic homolog 6 (SMAD 6) (Mothers
against DPP homolog 6) (Smad6) (hSMAD6). - Takifugu
rubripes
Length = 439
Score = 56.0 bits (129), Expect = 8e-07
Identities = 20/54 (37%), Positives = 31/54 (57%)
Frame = +1
Query: 103 PHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPP 264
P + C+++RW L LKP+ HC+ ++ VC NPYHY+++ P PP
Sbjct: 153 PQYLLCKMYRWSDLPFSARLKPLCHCQSFGSVENTNVCCNPYHYSRLCGPESPP 206
>UniRef50_O43541 Cluster: Mothers against decapentaplegic homolog 6;
n=15; Euteleostomi|Rep: Mothers against decapentaplegic
homolog 6 - Homo sapiens (Human)
Length = 496
Score = 55.2 bits (127), Expect = 1e-06
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Frame = +1
Query: 37 CVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC-EYAYQLKKDEV 213
CV +PR + + GQ P ++ RL+RWP LQ ELKP+ C +A V
Sbjct: 205 CVLVPRA---DLRLGGQ--PAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTV 259
Query: 214 CINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYAD 321
C NPYH++++ P PP R S + P +D
Sbjct: 260 CCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSD 295
>UniRef50_UPI0000E4A165 Cluster: PREDICTED: similar to inhibitory
protein SMAD6; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to inhibitory protein SMAD6 -
Strongylocentrotus purpuratus
Length = 371
Score = 54.4 bits (125), Expect = 3e-06
Identities = 33/88 (37%), Positives = 46/88 (52%), Gaps = 4/88 (4%)
Frame = +1
Query: 13 SSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAY 192
S +HT CV I + G G+ R PHV+ C+L+RWP+L+ ELK + C
Sbjct: 65 SRGGTHTNCVPISK------GELGR-RTVAPHVLCCQLFRWPELKHGSELKRLKFCCEIS 117
Query: 193 QLKKDE----VCINPYHYNKIDSPALPP 264
Q +E VC NPYH +++ P PP
Sbjct: 118 QQGDEESSGTVCCNPYHISRLCRPESPP 145
>UniRef50_UPI0000D554E6 Cluster: PREDICTED: similar to Mothers
against decapentaplegic homolog 6 (SMAD 6) (Mothers
against DPP homolog 6) (Smad6) (hSMAD6); n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Mothers against
decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP
homolog 6) (Smad6) (hSMAD6) - Tribolium castaneum
Length = 401
Score = 54.4 bits (125), Expect = 3e-06
Identities = 22/54 (40%), Positives = 31/54 (57%)
Frame = +1
Query: 103 PHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPP 264
PHV+ C+ WRWP L +LK + C +A VC NPYH++++ P PP
Sbjct: 96 PHVLCCQTWRWPDLLQSTDLKRLPACRFAGD--PVYVCCNPYHWSRVYQPDTPP 147
>UniRef50_UPI0000DB6F46 Cluster: PREDICTED: similar to Mothers
against decapentaplegic homolog 6 (SMAD 6) (Mothers
against DPP homolog 6) (Smad6) (hSMAD6), partial; n=1;
Apis mellifera|Rep: PREDICTED: similar to Mothers
against decapentaplegic homolog 6 (SMAD 6) (Mothers
against DPP homolog 6) (Smad6) (hSMAD6), partial - Apis
mellifera
Length = 251
Score = 54.0 bits (124), Expect = 3e-06
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 2/56 (3%)
Frame = +1
Query: 103 PHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEV--CINPYHYNKIDSPALPP 264
PH++ C++WRWP L ELK + C A KD V C NPYH++++ P PP
Sbjct: 5 PHLLCCQIWRWPDLAHSSELKRLPVCHSA----KDPVYICCNPYHWSRLCKPESPP 56
>UniRef50_Q21733 Cluster: Putative uncharacterized protein daf-8;
n=1; Caenorhabditis elegans|Rep: Putative
uncharacterized protein daf-8 - Caenorhabditis elegans
Length = 546
Score = 50.4 bits (115), Expect = 4e-05
Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 5/85 (5%)
Frame = +1
Query: 121 RLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPA--LPPILVRR---CS 285
R +R+P ++ + ++K + C +A+ VC+NPYHY ++ P +PPI+V +
Sbjct: 91 RAFRFPVIRYESQVKSILTCRHAFNSHSRNVCLNPYHYRWVELPTCQVPPIIVNKELDYG 150
Query: 286 EGEVRAPPPYADYHQPILHEHPDVA 360
E +R D++Q L E VA
Sbjct: 151 EPPIRTEDALDDWNQKDLKEEQVVA 175
>UniRef50_UPI00006A24F3 Cluster: UPI00006A24F3 related cluster; n=2;
Xenopus tropicalis|Rep: UPI00006A24F3 UniRef100 entry -
Xenopus tropicalis
Length = 361
Score = 50.0 bits (114), Expect = 5e-05
Identities = 20/54 (37%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Frame = +1
Query: 103 PHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKD--EVCINPYHYNKIDSPAL 258
P V+ C+L+RWP L+ ELK + CE ++ + +C NPYH++++ +P L
Sbjct: 87 PQVLLCKLYRWPDLRHGAELKRLIQCESFWRKSGEGTSLCCNPYHFSRLAAPVL 140
>UniRef50_A7S9K9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 324
Score = 48.0 bits (109), Expect = 2e-04
Identities = 23/47 (48%), Positives = 30/47 (63%)
Frame = +1
Query: 103 PHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKI 243
PHVV R +R P +QS +ELKP+ C K VCINP+HY++I
Sbjct: 50 PHVVLYRTFREPNVQSSNELKPLAICSRRDSTGK-RVCINPHHYSEI 95
>UniRef50_Q4H2T3 Cluster: Smad6/7; n=2; Ascidiacea|Rep: Smad6/7 -
Ciona intestinalis (Transparent sea squirt)
Length = 361
Score = 47.6 bits (108), Expect = 3e-04
Identities = 23/74 (31%), Positives = 43/74 (58%), Gaps = 2/74 (2%)
Frame = +1
Query: 37 CVTIPRVKPN-ESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEV 213
C + P V+ + E ++ + K ++ C+ +RWP L++ +L + +CE + + +
Sbjct: 57 CDSAPCVQLSPEHQLDPSFMKQSHEIMVCKAFRWPDLENMSQLCLMPYCE---SPQSNHI 113
Query: 214 CINPYHYNK-IDSP 252
C+NPYHY+K ID P
Sbjct: 114 CLNPYHYSKYIDLP 127
>UniRef50_Q70MW2 Cluster: Inhibitory SMAD; n=1; Crassostrea
gigas|Rep: Inhibitory SMAD - Crassostrea gigas (Pacific
oyster) (Crassostrea angulata)
Length = 359
Score = 47.2 bits (107), Expect = 4e-04
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Frame = +1
Query: 4 RAISSQN-SHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHC 180
R++ S+ T CV +P V+ ++ PHV+ C++WRWP+L L+ + C
Sbjct: 55 RSVESKGREETPCVLLPNVELKMGKMSTD-----PHVLCCQIWRWPELTLDTTLRRLPCC 109
Query: 181 EYAYQLKKDE--VCINPYHYN 237
E KD VC NPYH++
Sbjct: 110 E----TDKDPLYVCCNPYHWS 126
>UniRef50_Q8AWR7 Cluster: Smad7; n=15; Euteleostomi|Rep: Smad7 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 372
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/61 (34%), Positives = 35/61 (57%)
Frame = +1
Query: 82 GQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALP 261
GQ LP ++Y +++RWP L+ ELK + CE ++ + VC NP+H +++ P
Sbjct: 96 GQQSYPLPLLLY-KVFRWPDLRHSSELKRLSCCESYGKINPELVCCNPHHMSRLCELESP 154
Query: 262 P 264
P
Sbjct: 155 P 155
>UniRef50_Q61DE5 Cluster: Putative uncharacterized protein CBG12513;
n=1; Caenorhabditis briggsae|Rep: Putative
uncharacterized protein CBG12513 - Caenorhabditis
briggsae
Length = 531
Score = 45.2 bits (102), Expect = 0.002
Identities = 19/55 (34%), Positives = 33/55 (60%), Gaps = 2/55 (3%)
Frame = +1
Query: 121 RLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKI--DSPALPPILVRR 279
RL+R+ L+ + ++ + C + Y + + VC+NPYHYN + +PPI+V R
Sbjct: 105 RLFRFSCLKDERQITNIRSCRHKYVARGEIVCLNPYHYNFLIPKKEKMPPIMVTR 159
>UniRef50_O15105 Cluster: Mothers against decapentaplegic homolog 7;
n=19; Euteleostomi|Rep: Mothers against decapentaplegic
homolog 7 - Homo sapiens (Human)
Length = 426
Score = 42.7 bits (96), Expect = 0.008
Identities = 16/52 (30%), Positives = 31/52 (59%)
Frame = +1
Query: 109 VVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPP 264
++ C+++RWP L+ E+K + CE ++ + VC NP+H +++ PP
Sbjct: 157 LLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPP 208
>UniRef50_UPI000069FAC8 Cluster: Mothers against decapentaplegic
homolog 7 (SMAD 7) (Mothers against DPP homolog 7)
(Smad7) (hSMAD7).; n=1; Xenopus tropicalis|Rep: Mothers
against decapentaplegic homolog 7 (SMAD 7) (Mothers
against DPP homolog 7) (Smad7) (hSMAD7). - Xenopus
tropicalis
Length = 336
Score = 42.3 bits (95), Expect = 0.011
Identities = 20/73 (27%), Positives = 40/73 (54%)
Frame = +1
Query: 25 SHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKK 204
+ + C+ +P K + GQ LP ++ C+++RWP L+ E+K + C+ +
Sbjct: 88 ARSPCLLLPAAKLDSR--LGQQPFSLP-LLLCKVFRWPDLRHSSEVKRLSCCDSYGKNNP 144
Query: 205 DEVCINPYHYNKI 243
+ VC NP+H +++
Sbjct: 145 ELVCCNPHHLSRL 157
>UniRef50_UPI00015B5D64 Cluster: PREDICTED: similar to LD41184p;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
LD41184p - Nasonia vitripennis
Length = 858
Score = 35.5 bits (78), Expect = 1.3
Identities = 34/130 (26%), Positives = 48/130 (36%), Gaps = 7/130 (5%)
Frame = +1
Query: 10 ISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWP-------QLQSQHELKP 168
+ Q + T+PRV P +G L CR+ P QLQ Q +L+P
Sbjct: 335 LQQQAPQLQSSTLPRVPPIGAGQQMSCSLSLGRQKICRVISDPALKFQQLQLQHQRQLEP 394
Query: 169 VDHCEYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYADYHQPILHEH 348
+ E YQ ++ + P D P P V R + P PY HQ H+
Sbjct: 395 SELQEPHYQTPRNNSAVLPAGSGAYDLPPPKPPRVPRHLKPPPLPPHPYHQQHQQ--HQS 452
Query: 349 PDVAMQSGTG 378
Q +G
Sbjct: 453 SKGQQQQASG 462
>UniRef50_Q9N638 Cluster: Putative uncharacterized protein tag-68;
n=2; Caenorhabditis|Rep: Putative uncharacterized
protein tag-68 - Caenorhabditis elegans
Length = 415
Score = 35.5 bits (78), Expect = 1.3
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 5/44 (11%)
Frame = +1
Query: 118 CRLWRWPQLQ---SQHELKPVDHCEYAYQLKKDEV--CINPYHY 234
C+LWRW LQ + H L+ + C + + C NPYHY
Sbjct: 102 CKLWRWKDLQVDAALHRLEALPWCRFGRVTINNATVSCCNPYHY 145
>UniRef50_UPI0000D65DF2 Cluster: PREDICTED: similar to SMAD8
protein; n=1; Mus musculus|Rep: PREDICTED: similar to
SMAD8 protein - Mus musculus
Length = 419
Score = 35.1 bits (77), Expect = 1.7
Identities = 12/20 (60%), Positives = 14/20 (70%)
Frame = +2
Query: 581 CTTSPAFWCSISYYELNTRV 640
C P WCS++YYELN RV
Sbjct: 218 CYEEPQHWCSVAYYELNNRV 237
>UniRef50_Q5C800 Cluster: Putative uncharacterized protein; n=1;
Schistosoma japonicum|Rep: Putative uncharacterized
protein - Schistosoma japonicum (Blood fluke)
Length = 39
Score = 34.3 bits (75), Expect = 2.9
Identities = 15/30 (50%), Positives = 25/30 (83%)
Frame = -2
Query: 156 MLAL*LRPTPESAVNHMR*AFPVLSVDATL 67
M+AL +RP P SAV+++R AFPV ++++T+
Sbjct: 1 MMALQIRPPPYSAVDYVRQAFPVGNLESTI 30
>UniRef50_Q9VPL9 Cluster: CG3696-PA, isoform A; n=12; Diptera|Rep:
CG3696-PA, isoform A - Drosophila melanogaster (Fruit
fly)
Length = 5322
Score = 33.9 bits (74), Expect = 3.9
Identities = 27/101 (26%), Positives = 39/101 (38%), Gaps = 5/101 (4%)
Frame = +1
Query: 139 QLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDS--PALPPILVRRCSEGEVRAPPP 312
Q Q+Q + + Q + + P HY + P P + G+ P
Sbjct: 188 QQQAQQVQQQAQQQQQQQQQQSQQQARLPQHYPQAPGQHPLYPGVGAPTVQAGQPPTPQA 247
Query: 313 YAD--YHQPILHEHPDVAMQS-GTGHSALYLEATLAQHVPG 426
YA Y P+ H+ A Q G GH+ L + QHVPG
Sbjct: 248 YAHSPYGSPMQHQPSRGAPQHVGYGHTGLDQASAYGQHVPG 288
>UniRef50_A0DE90 Cluster: Chromosome undetermined scaffold_47, whole
genome shotgun sequence; n=3; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_47, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2171
Score = 33.9 bits (74), Expect = 3.9
Identities = 24/93 (25%), Positives = 43/93 (46%)
Frame = +1
Query: 142 LQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYAD 321
L+ E+ P+DH EY Y+ K+D I P + IDS L I+ E+ +D
Sbjct: 1545 LKQYSEIHPIDHSEYYYEWKQDLYEILP-NMKDIDSSILERII-------EILREEQISD 1596
Query: 322 YHQPILHEHPDVAMQSGTGHSALYLEATLAQHV 420
YH + ++ + +S L+++ Q++
Sbjct: 1597 YHIILQKQYLEKLQESQINKHQLHVKKNHIQYI 1629
>UniRef50_Q6UED9 Cluster: Phox2a splice variant 2; n=1; Xenopus
laevis|Rep: Phox2a splice variant 2 - Xenopus laevis
(African clawed frog)
Length = 116
Score = 33.5 bits (73), Expect = 5.1
Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 15/77 (19%)
Frame = +1
Query: 220 NPYHYNKIDS-----PALPPILVRRCSEGEVR--APPPYA---DYHQPILHE-----HPD 354
N + YN I S PA PP+ C+ G +R P PY+ Y H HP
Sbjct: 34 NSFQYNPIRSSFGANPACPPLTTANCTLGALRDHQPSPYSTGRTYRAHAGHSHAGSWHPH 93
Query: 355 VAMQSGTGHSALYLEAT 405
+A Q GT H + L AT
Sbjct: 94 IAQQDGT-HGSFILGAT 109
>UniRef50_A0QYG7 Cluster: Putative uncharacterized protein; n=1;
Mycobacterium smegmatis str. MC2 155|Rep: Putative
uncharacterized protein - Mycobacterium smegmatis
(strain ATCC 700084 / mc(2)155)
Length = 231
Score = 33.5 bits (73), Expect = 5.1
Identities = 14/45 (31%), Positives = 21/45 (46%)
Frame = +1
Query: 232 YNKIDSPALPPILVRRCSEGEVRAPPPYADYHQPILHEHPDVAMQ 366
Y +++ P P +L+ CS + P D HQ + H P V Q
Sbjct: 5 YGRVNEPYPPSVLIGPCSSNRIHPPHHQDDLHQ-VQHRRPQVQQQ 48
>UniRef50_Q2R140 Cluster: Retrotransposon protein, putative,
unclassified; n=9; cellular organisms|Rep:
Retrotransposon protein, putative, unclassified - Oryza
sativa subsp. japonica (Rice)
Length = 2446
Score = 33.5 bits (73), Expect = 5.1
Identities = 15/40 (37%), Positives = 20/40 (50%)
Frame = +3
Query: 453 NSGDSAPRLHQRRWRPDGPQ*QHEPHTSKSVTWRPXVRGL 572
++G S P WRPDGP P ++ WRP + GL
Sbjct: 322 SAGGSGPGWVNPGWRPDGPWVCFNPWPAQQPAWRPSLVGL 361
>UniRef50_A4H970 Cluster: 5'-3' exonuclease, putative; n=1; Leishmania
braziliensis|Rep: 5'-3' exonuclease, putative -
Leishmania braziliensis
Length = 1108
Score = 33.5 bits (73), Expect = 5.1
Identities = 17/35 (48%), Positives = 21/35 (60%)
Frame = -2
Query: 207 VLLQLVCILAMVHWLQFMLAL*LRPTPESAVNHMR 103
+LLQL CI A V WL F+L L + P SA + R
Sbjct: 1004 ILLQLCCICATVIWLAFVLGLAVTPKGRSAGSGQR 1038
>UniRef50_A7EFQ6 Cluster: Predicted protein; n=1; Sclerotinia
sclerotiorum 1980|Rep: Predicted protein - Sclerotinia
sclerotiorum 1980
Length = 531
Score = 33.1 bits (72), Expect = 6.7
Identities = 14/45 (31%), Positives = 23/45 (51%)
Frame = +1
Query: 226 YHYNKIDSPALPPILVRRCSEGEVRAPPPYADYHQPILHEHPDVA 360
YH+NK PA+P +L R+ + G R +Y P+ D++
Sbjct: 77 YHFNKDPLPAIPGVLARKLTRGSRRLDGRLNEYGDPVPRPCMDIS 121
>UniRef50_Q5XJS1 Cluster: Zgc:101624; n=2; Danio rerio|Rep:
Zgc:101624 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 32.7 bits (71), Expect = 8.9
Identities = 19/58 (32%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Frame = -1
Query: 211 PRPSSAGMHTRNGPL--ASVHVGSVTEANARVCSKPHAVGLSCTVR*CHSHSASPWVS 44
PRPSSAG + + PL + H S T C G CH HS W++
Sbjct: 231 PRPSSAGPRSSSAPLERKASHRASKTTKAQHTCKYKPIAGSDVVSEMCHDHSMD-WIN 287
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.316 0.135 0.426
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 696,571,163
Number of Sequences: 1657284
Number of extensions: 14024224
Number of successful extensions: 35494
Number of sequences better than 10.0: 57
Number of HSP's better than 10.0 without gapping: 34054
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 35441
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 55371905986
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
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