Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= br--1362
(846 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X66435-1|CAA47061.1| 520|Homo sapiens Hydroxymethylglutaryl CoA... 116 8e-26
L25798-1|AAA62411.1| 520|Homo sapiens 3-hydroxy-3-methylglutary... 115 2e-25
BT007302-1|AAP35966.1| 520|Homo sapiens 3-hydroxy-3-methylgluta... 115 2e-25
BC083514-1|AAH83514.1| 520|Homo sapiens 3-hydroxy-3-methylgluta... 115 2e-25
BC000297-1|AAH00297.2| 555|Homo sapiens HMGCS1 protein protein. 115 2e-25
AK095492-1|BAC04559.1| 509|Homo sapiens protein ( Homo sapiens ... 115 2e-25
CR456850-1|CAG33131.1| 508|Homo sapiens HMGCS2 protein. 108 3e-23
X83618-1|CAA58593.1| 508|Homo sapiens hydroxymethylglutaryl-CoA... 106 1e-22
U81859-1|AAB72036.1| 508|Homo sapiens 3-hydroxy-3-methylglutary... 106 1e-22
U12789-1|AAA92674.1| 363|Homo sapiens HMG CoA synthase protein. 106 1e-22
BC044217-1|AAH44217.1| 508|Homo sapiens 3-hydroxy-3-methylgluta... 106 1e-22
AL589734-2|CAI22408.1| 508|Homo sapiens 3-hydroxy-3-methylgluta... 106 1e-22
BC028407-1|AAH28407.1| 619|Homo sapiens ankyrin repeat domain 3... 33 1.3
AF269088-1|AAK27326.1| 1011|Homo sapiens breast cancer antigen N... 33 1.3
>X66435-1|CAA47061.1| 520|Homo sapiens Hydroxymethylglutaryl CoA
Synthase protein.
Length = 520
Score = 116 bits (280), Expect = 8e-26
Identities = 56/101 (55%), Positives = 72/101 (71%), Gaps = 5/101 (4%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKM-----RKTDPNFKGLL 167
+M HAYDFYKPD+ SE+P VDGKLSIQCYL+ALD CY+++ KK+ ++ + N L
Sbjct: 197 HMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEANDNDFTLN 256
Query: 168 SLDGMLFHSPYCKLVQKSLARVCFNDFLNYLLRNVRNNFLG 290
M+FHSPYCKLVQKSLAR+ NDFLN R+ + + G
Sbjct: 257 DFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSG 297
Score = 96.7 bits (230), Expect = 9e-20
Identities = 44/102 (43%), Positives = 67/102 (65%)
Frame = +1
Query: 499 EEVSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIM 678
+ + +FSYGSGLA+T+YS+ V D + GS L+K+ +SL + + LD R V F++ M
Sbjct: 368 KRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAQDVFAENM 427
Query: 679 DVRTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
+R +H Y P GS+D LF GT+YL ++D++ RRTY R+
Sbjct: 428 KLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Score = 90.2 bits (214), Expect = 8e-18
Identities = 46/101 (45%), Positives = 60/101 (59%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ +L F ++ + GL F + KLEDTYFDR+VEKAFM S LF +KTK
Sbjct: 273 KSLARMLLNDFLNDQNRDKNSIYSGLKAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 332
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL ++ GNMYT S+YG L S L SP L GK+ F
Sbjct: 333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQHLAGKRIGVF 373
>L25798-1|AAA62411.1| 520|Homo sapiens 3-hydroxy-3-methylglutaryl
coenzyme A synthase protein.
Length = 520
Score = 115 bits (277), Expect = 2e-25
Identities = 57/101 (56%), Positives = 72/101 (71%), Gaps = 5/101 (4%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMR---KTDPNFKG--LL 167
+M HAYDFYKPD+ SE+P VDGKLSIQCYL+ALD CY+++ KK+ + + N K L
Sbjct: 197 HMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLN 256
Query: 168 SLDGMLFHSPYCKLVQKSLARVCFNDFLNYLLRNVRNNFLG 290
M+FHSPYCKLVQKSLAR+ NDFLN R+ + + G
Sbjct: 257 DFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSG 297
Score = 99 bits (238), Expect = 1e-20
Identities = 45/102 (44%), Positives = 68/102 (66%)
Frame = +1
Query: 499 EEVSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIM 678
+ + +FSYGSGLA+T+YS+ V D + GS L+K+ +SL + + LD R V P F++ M
Sbjct: 368 KRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENM 427
Query: 679 DVRTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
+R +H Y P GS+D LF GT+YL ++D++ RRTY R+
Sbjct: 428 KLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Score = 92.3 bits (219), Expect = 2e-18
Identities = 47/101 (46%), Positives = 61/101 (60%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ +L F ++ + GL F + KLEDTYFDR+VEKAFM S LF +KTK
Sbjct: 273 KSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 332
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL ++ GNMYT S+YG L S L SP QL GK+ F
Sbjct: 333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVF 373
>BT007302-1|AAP35966.1| 520|Homo sapiens
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
(soluble) protein.
Length = 520
Score = 115 bits (277), Expect = 2e-25
Identities = 57/101 (56%), Positives = 72/101 (71%), Gaps = 5/101 (4%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMR---KTDPNFKG--LL 167
+M HAYDFYKPD+ SE+P VDGKLSIQCYL+ALD CY+++ KK+ + + N K L
Sbjct: 197 HMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLN 256
Query: 168 SLDGMLFHSPYCKLVQKSLARVCFNDFLNYLLRNVRNNFLG 290
M+FHSPYCKLVQKSLAR+ NDFLN R+ + + G
Sbjct: 257 DFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSG 297
Score = 99 bits (238), Expect = 1e-20
Identities = 45/102 (44%), Positives = 68/102 (66%)
Frame = +1
Query: 499 EEVSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIM 678
+ + +FSYGSGLA+T+YS+ V D + GS L+K+ +SL + + LD R V P F++ M
Sbjct: 368 KRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENM 427
Query: 679 DVRTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
+R +H Y P GS+D LF GT+YL ++D++ RRTY R+
Sbjct: 428 KLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Score = 92.3 bits (219), Expect = 2e-18
Identities = 47/101 (46%), Positives = 61/101 (60%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ +L F ++ + GL F + KLEDTYFDR+VEKAFM S LF +KTK
Sbjct: 273 KSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 332
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL ++ GNMYT S+YG L S L SP QL GK+ F
Sbjct: 333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVF 373
>BC083514-1|AAH83514.1| 520|Homo sapiens
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
(soluble) protein.
Length = 520
Score = 115 bits (277), Expect = 2e-25
Identities = 57/101 (56%), Positives = 72/101 (71%), Gaps = 5/101 (4%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMR---KTDPNFKG--LL 167
+M HAYDFYKPD+ SE+P VDGKLSIQCYL+ALD CY+++ KK+ + + N K L
Sbjct: 197 HMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLN 256
Query: 168 SLDGMLFHSPYCKLVQKSLARVCFNDFLNYLLRNVRNNFLG 290
M+FHSPYCKLVQKSLAR+ NDFLN R+ + + G
Sbjct: 257 DFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSG 297
Score = 101 bits (243), Expect = 2e-21
Identities = 46/102 (45%), Positives = 68/102 (66%)
Frame = +1
Query: 499 EEVSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIM 678
+ + +FSYGSGLA+T+YS+ V D + GS L+K+ +SL + + LD R V P F++ M
Sbjct: 368 KRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENM 427
Query: 679 DVRTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
+R YH Y P GS+D LF GT+YL ++D++ RRTY R+
Sbjct: 428 KLREDTYHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Score = 92.3 bits (219), Expect = 2e-18
Identities = 47/101 (46%), Positives = 61/101 (60%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ +L F ++ + GL F + KLEDTYFDR+VEKAFM S LF +KTK
Sbjct: 273 KSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 332
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL ++ GNMYT S+YG L S L SP QL GK+ F
Sbjct: 333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVF 373
>BC000297-1|AAH00297.2| 555|Homo sapiens HMGCS1 protein protein.
Length = 555
Score = 115 bits (277), Expect = 2e-25
Identities = 57/101 (56%), Positives = 72/101 (71%), Gaps = 5/101 (4%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMR---KTDPNFKG--LL 167
+M HAYDFYKPD+ SE+P VDGKLSIQCYL+ALD CY+++ KK+ + + N K L
Sbjct: 232 HMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLN 291
Query: 168 SLDGMLFHSPYCKLVQKSLARVCFNDFLNYLLRNVRNNFLG 290
M+FHSPYCKLVQKSLAR+ NDFLN R+ + + G
Sbjct: 292 DFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSG 332
Score = 99 bits (238), Expect = 1e-20
Identities = 45/102 (44%), Positives = 68/102 (66%)
Frame = +1
Query: 499 EEVSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIM 678
+ + +FSYGSGLA+T+YS+ V D + GS L+K+ +SL + + LD R V P F++ M
Sbjct: 403 KRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENM 462
Query: 679 DVRTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
+R +H Y P GS+D LF GT+YL ++D++ RRTY R+
Sbjct: 463 KLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 504
Score = 92.3 bits (219), Expect = 2e-18
Identities = 47/101 (46%), Positives = 61/101 (60%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ +L F ++ + GL F + KLEDTYFDR+VEKAFM S LF +KTK
Sbjct: 308 KSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 367
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL ++ GNMYT S+YG L S L SP QL GK+ F
Sbjct: 368 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVF 408
>AK095492-1|BAC04559.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ38173 fis, clone FCBBF1000053, highly similar to
HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC (EC
4.1.3.5). ).
Length = 509
Score = 115 bits (277), Expect = 2e-25
Identities = 57/101 (56%), Positives = 72/101 (71%), Gaps = 5/101 (4%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMR---KTDPNFKG--LL 167
+M HAYDFYKPD+ SE+P VDGKLSIQCYL+ALD CY+++ KK+ + + N K L
Sbjct: 186 HMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLN 245
Query: 168 SLDGMLFHSPYCKLVQKSLARVCFNDFLNYLLRNVRNNFLG 290
M+FHSPYCKLVQKSLAR+ NDFLN R+ + + G
Sbjct: 246 DFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSG 286
Score = 99 bits (238), Expect = 1e-20
Identities = 45/102 (44%), Positives = 68/102 (66%)
Frame = +1
Query: 499 EEVSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIM 678
+ + +FSYGSGLA+T+YS+ V D + GS L+K+ +SL + + LD R V P F++ M
Sbjct: 357 KRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENM 416
Query: 679 DVRTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
+R +H Y P GS+D LF GT+YL ++D++ RRTY R+
Sbjct: 417 KLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 458
Score = 92.3 bits (219), Expect = 2e-18
Identities = 47/101 (46%), Positives = 61/101 (60%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ +L F ++ + GL F + KLEDTYFDR+VEKAFM S LF +KTK
Sbjct: 262 KSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 321
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL ++ GNMYT S+YG L S L SP QL GK+ F
Sbjct: 322 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVF 362
>CR456850-1|CAG33131.1| 508|Homo sapiens HMGCS2 protein.
Length = 508
Score = 108 bits (259), Expect = 3e-23
Identities = 52/90 (57%), Positives = 66/90 (73%), Gaps = 6/90 (6%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMRK------TDPNFKGL 164
YM + YDFYKP+L+SE+P VDGKLSIQCYL ALD CY + KK++ +D F L
Sbjct: 234 YMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFT-L 292
Query: 165 LSLDGMLFHSPYCKLVQKSLARVCFNDFLN 254
L M+FH+P+CK+VQKSLAR+ FNDFL+
Sbjct: 293 DDLQYMIFHTPFCKMVQKSLARLMFNDFLS 322
Score = 96.3 bits (229), Expect = 1e-19
Identities = 43/100 (43%), Positives = 64/100 (64%)
Frame = +1
Query: 505 VSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIMDV 684
+ FSYGSGLA++ +S V D + GS L+KL+SS + L R+ V P +F++IM+
Sbjct: 407 IGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQ 466
Query: 685 RTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
R + YH + P G + LFPGT+YL ++D+Q RR Y R+
Sbjct: 467 REQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 506
Score = 72.5 bits (170), Expect = 2e-12
Identities = 35/101 (34%), Positives = 59/101 (58%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ + F ++ + + GL F KLEDTY +++++KA + S +F++KTK
Sbjct: 310 KSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTK 369
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL+++ + GNMYT +LYG L S L S +L G + F
Sbjct: 370 ASLYLSTHNGNMYTSTLYGCLASLLSHHSAQELAGSRIGAF 410
>X83618-1|CAA58593.1| 508|Homo sapiens hydroxymethylglutaryl-CoA
synthase protein.
Length = 508
Score = 106 bits (254), Expect = 1e-22
Identities = 51/90 (56%), Positives = 66/90 (73%), Gaps = 6/90 (6%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMRK------TDPNFKGL 164
+M + YDFYKP+L+SE+P VDGKLSIQCYL ALD CY + KK++ +D F L
Sbjct: 234 HMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFT-L 292
Query: 165 LSLDGMLFHSPYCKLVQKSLARVCFNDFLN 254
L M+FH+P+CK+VQKSLAR+ FNDFL+
Sbjct: 293 DDLQYMIFHTPFCKMVQKSLARLMFNDFLS 322
Score = 96.3 bits (229), Expect = 1e-19
Identities = 43/100 (43%), Positives = 64/100 (64%)
Frame = +1
Query: 505 VSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIMDV 684
+ FSYGSGLA++ +S V D + GS L+KL+SS + L R+ V P +F++IM+
Sbjct: 407 IGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQ 466
Query: 685 RTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
R + YH + P G + LFPGT+YL ++D+Q RR Y R+
Sbjct: 467 REQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 506
Score = 73.7 bits (173), Expect = 8e-13
Identities = 36/101 (35%), Positives = 59/101 (58%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ + F ++ + + GL F KLEDTY +++++KA + S +F++KTK
Sbjct: 310 KSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTK 369
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL+++ + GNMYT SLYG L S L S +L G + F
Sbjct: 370 ASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAF 410
>U81859-1|AAB72036.1| 508|Homo sapiens 3-hydroxy-3-methylglutaryl
CoA synthase protein.
Length = 508
Score = 106 bits (254), Expect = 1e-22
Identities = 51/90 (56%), Positives = 66/90 (73%), Gaps = 6/90 (6%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMRK------TDPNFKGL 164
+M + YDFYKP+L+SE+P VDGKLSIQCYL ALD CY + KK++ +D F L
Sbjct: 234 HMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFT-L 292
Query: 165 LSLDGMLFHSPYCKLVQKSLARVCFNDFLN 254
L M+FH+P+CK+VQKSLAR+ FNDFL+
Sbjct: 293 DDLQYMIFHTPFCKMVQKSLARLMFNDFLS 322
Score = 96.3 bits (229), Expect = 1e-19
Identities = 43/100 (43%), Positives = 64/100 (64%)
Frame = +1
Query: 505 VSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIMDV 684
+ FSYGSGLA++ +S V D + GS L+KL+SS + L R+ V P +F++IM+
Sbjct: 407 IGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQ 466
Query: 685 RTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
R + YH + P G + LFPGT+YL ++D+Q RR Y R+
Sbjct: 467 REQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 506
Score = 73.7 bits (173), Expect = 8e-13
Identities = 36/101 (35%), Positives = 59/101 (58%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ + F ++ + + GL F KLEDTY +++++KA + S +F++KTK
Sbjct: 310 KSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTK 369
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL+++ + GNMYT SLYG L S L S +L G + F
Sbjct: 370 ASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAF 410
>U12789-1|AAA92674.1| 363|Homo sapiens HMG CoA synthase protein.
Length = 363
Score = 106 bits (254), Expect = 1e-22
Identities = 51/90 (56%), Positives = 66/90 (73%), Gaps = 6/90 (6%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMRK------TDPNFKGL 164
+M + YDFYKP+L+SE+P VDGKLSIQCYL ALD CY + KK++ +D F L
Sbjct: 89 HMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFT-L 147
Query: 165 LSLDGMLFHSPYCKLVQKSLARVCFNDFLN 254
L M+FH+P+CK+VQKSLAR+ FNDFL+
Sbjct: 148 DDLQYMIFHTPFCKMVQKSLARLMFNDFLS 177
Score = 96.3 bits (229), Expect = 1e-19
Identities = 43/100 (43%), Positives = 64/100 (64%)
Frame = +1
Query: 505 VSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIMDV 684
+ FSYGSGLA++ +S V D + GS L+KL+SS + L R+ V P +F++IM+
Sbjct: 262 IGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQ 321
Query: 685 RTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
R + YH + P G + LFPGT+YL ++D+Q RR Y R+
Sbjct: 322 REQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 361
Score = 73.7 bits (173), Expect = 8e-13
Identities = 36/101 (35%), Positives = 59/101 (58%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ + F ++ + + GL F KLEDTY +++++KA + S +F++KTK
Sbjct: 165 KSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTK 224
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL+++ + GNMYT SLYG L S L S +L G + F
Sbjct: 225 ASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAF 265
>BC044217-1|AAH44217.1| 508|Homo sapiens
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
(mitochondrial) protein.
Length = 508
Score = 106 bits (254), Expect = 1e-22
Identities = 51/90 (56%), Positives = 66/90 (73%), Gaps = 6/90 (6%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMRK------TDPNFKGL 164
+M + YDFYKP+L+SE+P VDGKLSIQCYL ALD CY + KK++ +D F L
Sbjct: 234 HMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFT-L 292
Query: 165 LSLDGMLFHSPYCKLVQKSLARVCFNDFLN 254
L M+FH+P+CK+VQKSLAR+ FNDFL+
Sbjct: 293 DDLQYMIFHTPFCKMVQKSLARLMFNDFLS 322
Score = 96.3 bits (229), Expect = 1e-19
Identities = 43/100 (43%), Positives = 64/100 (64%)
Frame = +1
Query: 505 VSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIMDV 684
+ FSYGSGLA++ +S V D + GS L+KL+SS + L R+ V P +F++IM+
Sbjct: 407 IGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQ 466
Query: 685 RTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
R + YH + P G + LFPGT+YL ++D+Q RR Y R+
Sbjct: 467 REQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 506
Score = 73.7 bits (173), Expect = 8e-13
Identities = 36/101 (35%), Positives = 59/101 (58%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ + F ++ + + GL F KLEDTY +++++KA + S +F++KTK
Sbjct: 310 KSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTK 369
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL+++ + GNMYT SLYG L S L S +L G + F
Sbjct: 370 ASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAF 410
>AL589734-2|CAI22408.1| 508|Homo sapiens
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
(mitochondrial) protein.
Length = 508
Score = 106 bits (254), Expect = 1e-22
Identities = 51/90 (56%), Positives = 66/90 (73%), Gaps = 6/90 (6%)
Frame = +3
Query: 3 YMTHAYDFYKPDLSSEFPYVDGKLSIQCYLNALDNCYNLFSKKMRK------TDPNFKGL 164
+M + YDFYKP+L+SE+P VDGKLSIQCYL ALD CY + KK++ +D F L
Sbjct: 234 HMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFT-L 292
Query: 165 LSLDGMLFHSPYCKLVQKSLARVCFNDFLN 254
L M+FH+P+CK+VQKSLAR+ FNDFL+
Sbjct: 293 DDLQYMIFHTPFCKMVQKSLARLMFNDFLS 322
Score = 96.3 bits (229), Expect = 1e-19
Identities = 43/100 (43%), Positives = 64/100 (64%)
Frame = +1
Query: 505 VSLFSYGSGLASTMYSINVCHDMSTGSKLEKLISSLHETVALLDKRQSVEPSKFSDIMDV 684
+ FSYGSGLA++ +S V D + GS L+KL+SS + L R+ V P +F++IM+
Sbjct: 407 IGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQ 466
Query: 685 RTKNYHSAPYEPTGSLDVLFPGTYYL*KIDDQRRRTYDRK 804
R + YH + P G + LFPGT+YL ++D+Q RR Y R+
Sbjct: 467 REQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 506
Score = 73.7 bits (173), Expect = 8e-13
Identities = 36/101 (35%), Positives = 59/101 (58%)
Frame = +2
Query: 215 KIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYFDREVEKAFMTYSLSLFEEKTK 394
K +++ + F ++ + + GL F KLEDTY +++++KA + S +F++KTK
Sbjct: 310 KSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTK 369
Query: 395 PSLHIARNVGNMYTPSLYGGLVSYLISKSPDQLIGKKFLCF 517
SL+++ + GNMYT SLYG L S L S +L G + F
Sbjct: 370 ASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAF 410
>BC028407-1|AAH28407.1| 619|Homo sapiens ankyrin repeat domain 30B
protein.
Length = 619
Score = 33.1 bits (72), Expect = 1.3
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Frame = +2
Query: 212 SKIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYF----DREVEKAFMTYSLSLF 379
+KIISKS Q ++ LP +K + NHK+ED F RE ++ + S SLF
Sbjct: 442 TKIISKSAAQNYTCLPDATYQKDIKTI----NHKIEDQMFPSESKREEDEEYSWDSGSLF 497
Query: 380 EEKTKPSLHIARNV 421
E K + I ++
Sbjct: 498 ESSAKTQVCIPESM 511
>AF269088-1|AAK27326.1| 1011|Homo sapiens breast cancer antigen
NY-BR-1.1 protein.
Length = 1011
Score = 33.1 bits (72), Expect = 1.3
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Frame = +2
Query: 212 SKIISKSVLQ*FSELPAEEREKQFPGLSEFSNHKLEDTYF----DREVEKAFMTYSLSLF 379
+KIISKS Q ++ LP +K + NHK+ED F RE ++ + S SLF
Sbjct: 289 TKIISKSAAQNYTCLPDATYQKDIKTI----NHKIEDQMFPSESKREEDEEYSWDSGSLF 344
Query: 380 EEKTKPSLHIARNV 421
E K + I ++
Sbjct: 345 ESSAKTQVCIPESM 358
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 117,967,636
Number of Sequences: 237096
Number of extensions: 2384003
Number of successful extensions: 3833
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 3686
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3821
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10705443456
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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