Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= br--1244X
(525 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 139 3e-32
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 81 2e-14
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 80 4e-14
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 80 4e-14
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 64 2e-09
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 64 2e-09
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 62 1e-08
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 62 1e-08
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 60 4e-08
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 59 7e-08
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 56 5e-07
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 56 7e-07
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 55 9e-07
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 55 1e-06
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 54 2e-06
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 50 3e-05
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 49 8e-05
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 47 2e-04
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 47 3e-04
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 44 0.002
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 44 0.002
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 43 0.004
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 43 0.005
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 42 0.011
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 41 0.020
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 41 0.020
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 41 0.020
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 38 0.14
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 36 0.43
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 36 0.43
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 36 0.75
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 34 2.3
UniRef50_Q1FI64 Cluster: Small GTP-binding protein domain; n=11;... 33 3.0
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 33 3.0
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 33 4.0
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 33 4.0
UniRef50_Q5D2M8 Cluster: Eisenstasin II; n=1; Eisenia andrei|Rep... 33 5.3
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 33 5.3
UniRef50_A6G856 Cluster: Putative uncharacterized protein; n=1; ... 32 7.0
UniRef50_A0D5K2 Cluster: Chromosome undetermined scaffold_39, wh... 32 7.0
UniRef50_A7EJZ1 Cluster: Putative uncharacterized protein; n=1; ... 32 7.0
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 32 7.0
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 32 9.3
UniRef50_Q5D2M9 Cluster: Eisenstasin I; n=1; Eisenia andrei|Rep:... 32 9.3
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 139 bits (337), Expect = 3e-32
Identities = 63/87 (72%), Positives = 73/87 (83%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 428
G R CTLIPGDGVGPELV +QEVFK+A +PVDFE +F SEVNP LSA LEDV+ SI
Sbjct: 37 GNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAKLEDVIASIRK 96
Query: 429 NKICIKGILATPDFSHTGELQTLNMKL 509
NK+CIKG+LATPD+S+ GELQ+LNMKL
Sbjct: 97 NKVCIKGVLATPDYSNVGELQSLNMKL 123
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 81.0 bits (191), Expect = 2e-14
Identities = 41/82 (50%), Positives = 58/82 (70%), Gaps = 1/82 (1%)
Frame = +3
Query: 267 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICI 443
T++PGDGVGPEL++AV+EVFKAAS+PV+F+ SEV N LE V++S+ NK+ I
Sbjct: 20 TMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAI 79
Query: 444 KGILATPDFSHTGELQTLNMKL 509
G + TP + GEL + +M+L
Sbjct: 80 IGKIHTP-MEYKGELASYDMRL 100
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 79.8 bits (188), Expect = 4e-14
Identities = 40/82 (48%), Positives = 58/82 (70%), Gaps = 1/82 (1%)
Frame = +3
Query: 267 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICI 443
T++PGDGVGPEL++AV+EVFKAA++PV+F+ SEV N LE V++S+ NK+ I
Sbjct: 52 TMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAI 111
Query: 444 KGILATPDFSHTGELQTLNMKL 509
G + TP + GEL + +M+L
Sbjct: 112 IGKIHTP-MEYKGELASYDMRL 132
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 79.8 bits (188), Expect = 4e-14
Identities = 40/82 (48%), Positives = 58/82 (70%), Gaps = 1/82 (1%)
Frame = +3
Query: 267 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICI 443
T++PGDGVGPEL++AV+EVFKAA++PV+F+ SEV N LE V++S+ NK+ I
Sbjct: 52 TMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAI 111
Query: 444 KGILATPDFSHTGELQTLNMKL 509
G + TP + GEL + +M+L
Sbjct: 112 IGKIHTP-MEYKGELASYDMRL 132
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 64.1 bits (149), Expect = 2e-09
Identities = 32/71 (45%), Positives = 49/71 (69%), Gaps = 2/71 (2%)
Frame = +3
Query: 258 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDF-ESFFFSEVNPTLSAPLE-DVVNSIAVN 431
IK TL PGDG+GPE+ +V++VF AA + +D+ E F +EV+P ++ L D + S+ N
Sbjct: 44 IKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKN 103
Query: 432 KICIKGILATP 464
K+ +KG +ATP
Sbjct: 104 KVGLKGPMATP 114
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 64.1 bits (149), Expect = 2e-09
Identities = 36/81 (44%), Positives = 51/81 (62%)
Frame = +3
Query: 267 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIK 446
TLIPGDG+GP + AV++V +A PV FE + EV + E+V+ S+ NK+C+K
Sbjct: 42 TLIPGDGIGPLVTGAVEQVMEAMHAPVHFERY---EVLGNMRKVPEEVIESVKRNKVCLK 98
Query: 447 GILATPDFSHTGELQTLNMKL 509
G LATP G + +LNM+L
Sbjct: 99 GGLATP---VGGGVSSLNMQL 116
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 61.7 bits (143), Expect = 1e-08
Identities = 34/91 (37%), Positives = 53/91 (58%), Gaps = 4/91 (4%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVN----PTLSAPLEDVVN 416
G R TLIPGDG+GPE+V AVQ++F+ +PVDFE S ++ + + +
Sbjct: 48 GGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107
Query: 417 SIAVNKICIKGILATPDFSHTGELQTLNMKL 509
SI N + +KG + TP + G ++LN++L
Sbjct: 108 SIKRNGVAMKGNIFTPLDAIPG-FRSLNLEL 137
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 61.7 bits (143), Expect = 1e-08
Identities = 35/87 (40%), Positives = 52/87 (59%), Gaps = 3/87 (3%)
Frame = +3
Query: 210 IFNKVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTL 389
IF++ I G R T+IPGDG+GPEL+ V+ VF+ A +PVDFE EV+ +
Sbjct: 39 IFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSS 93
Query: 390 SAPLEDVVNSIAV---NKICIKGILAT 461
+A ED+ N+I N++ +KG + T
Sbjct: 94 NADEEDIRNAIMAIRRNRVALKGNIET 120
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 59.7 bits (138), Expect = 4e-08
Identities = 33/81 (40%), Positives = 51/81 (62%)
Frame = +3
Query: 267 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIK 446
TLIPGDG+GP + AV++V +A P+ FE + +V+ +S +V+ SI NK+C+K
Sbjct: 41 TLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKY---DVHGEMSRVPPEVMESIRKNKVCLK 97
Query: 447 GILATPDFSHTGELQTLNMKL 509
G L TP G + +LN++L
Sbjct: 98 GGLKTP---VGGGVSSLNVQL 115
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 58.8 bits (136), Expect = 7e-08
Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 3/82 (3%)
Frame = +3
Query: 210 IFNKVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTL 389
IF++ I G R T+IPGDG+GPEL+ V+ VF+ A +PVDFE EV+ +
Sbjct: 12 IFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSS 66
Query: 390 SAPLEDVVNSIAV---NKICIK 446
+A ED+ N+I N++ +K
Sbjct: 67 NADEEDICNAIMAIRRNRVALK 88
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 56.0 bits (129), Expect = 5e-07
Identities = 31/83 (37%), Positives = 48/83 (57%), Gaps = 2/83 (2%)
Frame = +3
Query: 219 KVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA- 395
KV+ + + G R T++PG G+GPEL+ V+EVF+ A +PVDFE +++P
Sbjct: 37 KVEKIPKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFE---VVDIDPASEGN 93
Query: 396 -PLEDVVNSIAVNKICIKGILAT 461
LE + SI N + +KG + T
Sbjct: 94 DDLEYAITSIKRNGVALKGNIET 116
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 55.6 bits (128), Expect = 7e-07
Identities = 28/72 (38%), Positives = 44/72 (61%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 428
G R TLIPGDGVG E+ +V+ +F+A +IP+D+E+ + + + + V S+
Sbjct: 26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDH--KEGVYEAVESLKR 83
Query: 429 NKICIKGILATP 464
NKI +KG+ TP
Sbjct: 84 NKIGLKGLWHTP 95
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 55.2 bits (127), Expect = 9e-07
Identities = 35/104 (33%), Positives = 57/104 (54%), Gaps = 2/104 (1%)
Frame = +3
Query: 159 FGNNGEKCMLCTIWSPAIFNKVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAAS 338
F N + L T+ P+I + + G+ + I GDG+GPE+ +V+++F AA+
Sbjct: 6 FFRNTSRRFLATVKQPSI-GRYTGKPNPSTGK-YTVSFIEGDGIGPEISKSVKKIFSAAN 63
Query: 339 IPVDFESFFFSE--VNPTLSAPLEDVVNSIAVNKICIKGILATP 464
+P+++ES S VN + P + V SI N + +KG LATP
Sbjct: 64 VPIEWESCDVSPIFVNGLTTIP-DPAVQSITKNLVALKGPLATP 106
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 54.8 bits (126), Expect = 1e-06
Identities = 29/72 (40%), Positives = 45/72 (62%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 428
G R TLIPGDGVG E+ +V ++F+ +IP+D+E+ S + T + ++ V S+
Sbjct: 27 GGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTEN--VQRAVESLKR 84
Query: 429 NKICIKGILATP 464
NK+ +KGI TP
Sbjct: 85 NKVGLKGIWHTP 96
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 54.4 bits (125), Expect = 2e-06
Identities = 27/71 (38%), Positives = 43/71 (60%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 428
G R TLIPGDG+GPEL+ V+E+F+ + +PVDFE + + T + + + +I
Sbjct: 48 GGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS-SSTSEDDISNAIMAIRR 106
Query: 429 NKICIKGILAT 461
N + +KG + T
Sbjct: 107 NGVALKGNIET 117
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 50.0 bits (114), Expect = 3e-05
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--PLEDVVNSI 422
G R T++PG G+GPEL+ V+E+F+ P+DFE +++P+ L+ + SI
Sbjct: 55 GGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVI---DIDPSTEGNDDLDYAITSI 111
Query: 423 AVNKICIKGILATPDFSHT 479
N + +KG + T S T
Sbjct: 112 KRNGVALKGNIETKSQSLT 130
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 48.8 bits (111), Expect = 8e-05
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Frame = +3
Query: 213 FNKVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLS 392
F+ + T G G TLIPGDG+GPE+ AV ++F AA P+ +E + +
Sbjct: 17 FHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGG 76
Query: 393 APL--EDVVNSIAVNKICIKGILATP 464
+ + S+ NK+ +KG L TP
Sbjct: 77 KWMIPSEAKESMDKNKMGLKGPLKTP 102
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 47.2 bits (107), Expect = 2e-04
Identities = 26/69 (37%), Positives = 38/69 (55%), Gaps = 1/69 (1%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 437
K TLIPGDGVGPE+ A ++ A + +D++ EV + V++SI NKI
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANKI 62
Query: 438 CIKGILATP 464
+K + TP
Sbjct: 63 ALKAPITTP 71
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 46.8 bits (106), Expect = 3e-04
Identities = 25/71 (35%), Positives = 41/71 (57%), Gaps = 3/71 (4%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV---NPTLSAPLEDVVNSIAVN 431
+ TLIPGDG+GPE+ +VQ++F+AA P+ ++ + V + P + + N
Sbjct: 26 RVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIP-SRCIELMHAN 84
Query: 432 KICIKGILATP 464
K+ +KG L TP
Sbjct: 85 KVGLKGPLETP 95
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 44.4 bits (100), Expect = 0.002
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFS-EVNPTLSAPL-EDVVNSIAVNK 434
+ TLIPGDG+GPE+ A+ V +A+ + +++ EV PL V+ SI +
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEAGVEVIEKYGTPLPPQVLESIRETR 63
Query: 435 ICIKGILATP 464
+ IKG + TP
Sbjct: 64 VAIKGPIGTP 73
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 44.0 bits (99), Expect = 0.002
Identities = 26/75 (34%), Positives = 44/75 (58%), Gaps = 3/75 (4%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFE--SFFFSEVNPTLSAPL-EDVVNS 419
GR++ T+IPGDG+GPE V A +V +AA P+ +E S +++ + ++ + S
Sbjct: 18 GRKL-ITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIES 76
Query: 420 IAVNKICIKGILATP 464
I ++ +KG L TP
Sbjct: 77 IRKTRVVLKGPLETP 91
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 43.2 bits (97), Expect = 0.004
Identities = 26/70 (37%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF-SEVNPTLSAPLEDVVN-SIAVNK 434
K TLIPGDG+GPE+ A V +A + ++ESF +E + +N SI +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 435 ICIKGILATP 464
I +KG + TP
Sbjct: 64 IGLKGPVTTP 73
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 42.7 bits (96), Expect = 0.005
Identities = 27/73 (36%), Positives = 39/73 (53%), Gaps = 2/73 (2%)
Frame = +3
Query: 252 RRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIA 425
++I TLIPGDG+GPE+V V VF A P +E+ S L + ++SI
Sbjct: 8 QQIPVTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQTTLDSIG 67
Query: 426 VNKICIKGILATP 464
+ +KG L+TP
Sbjct: 68 RTGLALKGPLSTP 80
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 41.5 bits (93), Expect = 0.011
Identities = 27/65 (41%), Positives = 38/65 (58%), Gaps = 2/65 (3%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPV--DFESFFFSEVNPTLSAPLEDVVNSIAVNK 434
K TLI G+GVG EL+ AVQEV A P+ D F ++ + +S +V+ S+ NK
Sbjct: 71 KVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVS---PEVLKSLRANK 127
Query: 435 ICIKG 449
+ IKG
Sbjct: 128 VGIKG 132
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 40.7 bits (91), Expect = 0.020
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Frame = +3
Query: 258 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE--VNPTLSAPL-EDVVNSIAV 428
I T+ GDG+GPE++ AV V K A++P+ E+ E N + + ED + I
Sbjct: 5 IPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFR 64
Query: 429 NKICIKGILATPDFSHTGELQTLNMKL 509
K +KG + TP G ++LN+ L
Sbjct: 65 TKALLKGPVTTP---QGGGYKSLNVTL 88
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 40.7 bits (91), Expect = 0.020
Identities = 25/70 (35%), Positives = 36/70 (51%)
Frame = +3
Query: 213 FNKVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLS 392
F++ I G + T+ PGDG GPEL+ V +A +PVDFE EV + +
Sbjct: 1 FSQQTIPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFE-----EVVVSSN 55
Query: 393 APLEDVVNSI 422
A ED+ S+
Sbjct: 56 ADEEDIRTSL 65
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 40.7 bits (91), Expect = 0.020
Identities = 16/27 (59%), Positives = 21/27 (77%)
Frame = +3
Query: 267 TLIPGDGVGPELVYAVQEVFKAASIPV 347
TLIPGDG+GPE+ AV ++F AA P+
Sbjct: 8 TLIPGDGIGPEISAAVMKIFDAAKAPI 34
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 37.9 bits (84), Expect = 0.14
Identities = 26/72 (36%), Positives = 36/72 (50%), Gaps = 4/72 (5%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF---SEVNPTLSAPL-EDVVNSIAV 428
+ TLI GDG+GPE+ A + V A I DFE +EV PL V+ ++
Sbjct: 5 RVTLIRGDGIGPEVTQAARIVLDATGI--DFEWVVVDAGAEVMEKSGTPLPAPVIEAVRA 62
Query: 429 NKICIKGILATP 464
+ IKG + TP
Sbjct: 63 SDAAIKGPITTP 74
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 36.3 bits (80), Expect = 0.43
Identities = 20/44 (45%), Positives = 26/44 (59%)
Frame = +3
Query: 243 NKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE 374
N + +IPGDG+GPELV + EV +AA+ D E F SE
Sbjct: 2 NAPHALDIAVIPGDGIGPELVRSAVEVLRAAA-GRDVELRFTSE 44
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 36.3 bits (80), Expect = 0.43
Identities = 15/27 (55%), Positives = 20/27 (74%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFK 329
G R T+IPGDG+GPEL+ V+ VF+
Sbjct: 110 GGRHTVTMIPGDGIGPELMLHVKSVFR 136
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 35.5 bits (78), Expect = 0.75
Identities = 16/38 (42%), Positives = 24/38 (63%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE 374
+ T++PGDG+GPE+ V +AA + ESF F+E
Sbjct: 40 RVTVLPGDGIGPEITAVTLSVLEAAG-KAEGESFTFTE 76
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 33.9 bits (74), Expect = 2.3
Identities = 16/28 (57%), Positives = 20/28 (71%)
Frame = +3
Query: 270 LIPGDGVGPELVYAVQEVFKAASIPVDF 353
+I GDGVGPELV A+ +V AA V+F
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEF 34
>UniRef50_Q1FI64 Cluster: Small GTP-binding protein domain; n=11;
Bacteria|Rep: Small GTP-binding protein domain -
Clostridium phytofermentans ISDg
Length = 429
Score = 33.5 bits (73), Expect = 3.0
Identities = 20/62 (32%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Frame = +3
Query: 216 NKVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAA-SIPVDFESFFFSEVNPTLS 392
NK++ A E + + + G GV EL+Y V ++ K + P+ FE +F E N +S
Sbjct: 297 NKIKEAFESKGIKVFPISAVSGQGV-KELLYYVSDLLKTVDATPIVFEKEYFPEENLVMS 355
Query: 393 AP 398
P
Sbjct: 356 EP 357
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 33.5 bits (73), Expect = 3.0
Identities = 13/30 (43%), Positives = 20/30 (66%)
Frame = +3
Query: 270 LIPGDGVGPELVYAVQEVFKAASIPVDFES 359
+IPGDG+G E++ A V +A +P FE+
Sbjct: 10 VIPGDGIGREVIPAAVAVLRATGLPFHFEN 39
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 33.1 bits (72), Expect = 4.0
Identities = 13/30 (43%), Positives = 20/30 (66%)
Frame = +3
Query: 249 GRRIKCTLIPGDGVGPELVYAVQEVFKAAS 338
G ++ ++PGDG+GPE+ A V +AAS
Sbjct: 10 GNVMQLIVLPGDGIGPEITTATSGVLRAAS 39
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 33.1 bits (72), Expect = 4.0
Identities = 19/62 (30%), Positives = 31/62 (50%)
Frame = +3
Query: 219 KVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAP 398
+++ A +R L+PGDG+GPE++ + V + A E F F E+ P A
Sbjct: 34 RIRCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLE-FDFKEM-PVGGAA 91
Query: 399 LE 404
L+
Sbjct: 92 LD 93
>UniRef50_Q5D2M8 Cluster: Eisenstasin II; n=1; Eisenia andrei|Rep:
Eisenstasin II - Eisenia andrei
Length = 187
Score = 32.7 bits (71), Expect = 5.3
Identities = 10/19 (52%), Positives = 12/19 (63%)
Frame = +3
Query: 135 CWKGCTHKFGNNGEKCMLC 191
CWK CTH F N+ C +C
Sbjct: 52 CWKECTHGFMNDSRGCQIC 70
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 32.7 bits (71), Expect = 5.3
Identities = 13/30 (43%), Positives = 19/30 (63%)
Frame = +3
Query: 258 IKCTLIPGDGVGPELVYAVQEVFKAASIPV 347
IK ++PGDG+G E+ A VF+ +PV
Sbjct: 7 IKIAVLPGDGIGIEVTEATLPVFEVLDVPV 36
>UniRef50_A6G856 Cluster: Putative uncharacterized protein; n=1;
Plesiocystis pacifica SIR-1|Rep: Putative
uncharacterized protein - Plesiocystis pacifica SIR-1
Length = 556
Score = 32.3 bits (70), Expect = 7.0
Identities = 12/42 (28%), Positives = 22/42 (52%)
Frame = +3
Query: 219 KVQIATEGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIP 344
+ +A E N R+ L+ G+G+ P+L++ +V S P
Sbjct: 245 RTNVAIEMNTSRKCSAALVAGEGIPPQLIFVDNDVVVQQSFP 286
>UniRef50_A0D5K2 Cluster: Chromosome undetermined scaffold_39, whole
genome shotgun sequence; n=1; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_39, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2756
Score = 32.3 bits (70), Expect = 7.0
Identities = 20/57 (35%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Frame = +3
Query: 321 VFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSI--AVNKICIKGILATPDFSHTGE 485
++ ++ I ++F FSEVN S +E + +I V+ I I+GILA+ S+T E
Sbjct: 1301 IYSSSQIFLNFNQMVFSEVNLESSYLIEIIGENIFYVVSNIDIRGILASNSMSNTYE 1357
>UniRef50_A7EJZ1 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 567
Score = 32.3 bits (70), Expect = 7.0
Identities = 19/59 (32%), Positives = 28/59 (47%)
Frame = +3
Query: 237 EGNKGRRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVV 413
EG KG C + G G PEL+ QE + +P++ F + PTL +E +V
Sbjct: 501 EGGKGVP-SCYWLFG-GTDPELIRKAQETGRMEDVPINHGPLFLPVIQPTLKTGVEILV 557
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 32.3 bits (70), Expect = 7.0
Identities = 13/32 (40%), Positives = 21/32 (65%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE 356
K + GDG+GPE++ A EVF A + ++F+
Sbjct: 3 KIVTLAGDGIGPEIMAAGLEVFDAVAQKINFD 34
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 31.9 bits (69), Expect = 9.3
Identities = 10/29 (34%), Positives = 22/29 (75%)
Frame = +3
Query: 261 KCTLIPGDGVGPELVYAVQEVFKAASIPV 347
K +IPGDG+G E++ +++F++ ++P+
Sbjct: 12 KIIVIPGDGIGAEVMNEAEKMFQSLNLPI 40
>UniRef50_Q5D2M9 Cluster: Eisenstasin I; n=1; Eisenia andrei|Rep:
Eisenstasin I - Eisenia andrei
Length = 156
Score = 31.9 bits (69), Expect = 9.3
Identities = 10/19 (52%), Positives = 12/19 (63%)
Frame = +3
Query: 135 CWKGCTHKFGNNGEKCMLC 191
CWK CTH F N+ C +C
Sbjct: 50 CWKECTHGFLNDSRGCQVC 68
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 532,149,512
Number of Sequences: 1657284
Number of extensions: 11099285
Number of successful extensions: 27395
Number of sequences better than 10.0: 44
Number of HSP's better than 10.0 without gapping: 26619
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 27384
length of database: 575,637,011
effective HSP length: 95
effective length of database: 418,195,031
effective search space used: 33037407449
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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