Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= br--0398
(588 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P09874 Cluster: Poly [ADP-ribose] polymerase 1 (EC 2.4.... 76 7e-13
UniRef50_Q4RR03 Cluster: Chromosome 14 SCAF15003, whole genome s... 74 2e-12
UniRef50_UPI00015B52AF Cluster: PREDICTED: similar to poly(ADP-r... 71 3e-11
UniRef50_Q7Z115 Cluster: NAD(+) ADP-ribosyltransferase-1A; n=2; ... 69 1e-10
UniRef50_UPI0000E4A1FC Cluster: PREDICTED: similar to Poly [ADP-... 62 9e-09
UniRef50_P35875-2 Cluster: Isoform I of P35875 ; n=2; Drosophila... 57 3e-07
UniRef50_P35875 Cluster: Poly [ADP-ribose] polymerase (EC 2.4.2.... 57 3e-07
UniRef50_UPI00005A2C99 Cluster: PREDICTED: similar to Poly [ADP-... 56 8e-07
UniRef50_A7TC91 Cluster: Predicted protein; n=1; Nematostella ve... 56 8e-07
UniRef50_A5AIW8 Cluster: Putative uncharacterized protein; n=1; ... 53 6e-06
UniRef50_A0DM45 Cluster: Chromosome undetermined scaffold_56, wh... 52 1e-05
UniRef50_Q9N4H4 Cluster: Poly(ADP-ribose) polymerase pme-1; n=2;... 52 1e-05
UniRef50_Q54CP3 Cluster: Poly(ADP-ribosyl)transferase; n=3; Dict... 51 2e-05
UniRef50_Q9UGN5 Cluster: Poly [ADP-ribose] polymerase 2 (EC 2.4.... 51 2e-05
UniRef50_Q9ZP54 Cluster: Poly [ADP-ribose] polymerase 1 (EC 2.4.... 51 2e-05
UniRef50_A0BXK8 Cluster: Chromosome undetermined scaffold_134, w... 49 7e-05
UniRef50_Q24FE8 Cluster: WGR domain containing protein; n=1; Tet... 49 9e-05
UniRef50_Q5C0T7 Cluster: SJCHGC03992 protein; n=1; Schistosoma j... 46 7e-04
UniRef50_Q9Y6F1 Cluster: Poly [ADP-ribose] polymerase 3 (EC 2.4.... 45 0.001
UniRef50_UPI0000E48B4F Cluster: PREDICTED: hypothetical protein;... 44 0.002
UniRef50_A2ZSW8 Cluster: Putative uncharacterized protein; n=1; ... 44 0.002
UniRef50_Q54X55 Cluster: Poly(ADP-ribosyl)transferase; n=2; Dict... 43 0.005
UniRef50_Q0V159 Cluster: Putative uncharacterized protein; n=1; ... 43 0.005
UniRef50_UPI0000D9A214 Cluster: PREDICTED: poly (ADP-ribose) pol... 42 0.008
UniRef50_A1DF96 Cluster: Poly(ADP)-ribose polymerase PARP, putat... 40 0.033
UniRef50_Q22MT0 Cluster: WGR domain containing protein; n=2; Tet... 38 0.23
UniRef50_Q11207 Cluster: Poly [ADP-ribose] polymerase 2 (EC 2.4.... 37 0.30
UniRef50_UPI00004998EE Cluster: poly(ADP-ribose) polymerase; n=2... 37 0.40
UniRef50_Q24GE4 Cluster: WGR domain containing protein; n=2; Tet... 37 0.40
UniRef50_A0CTW4 Cluster: Chromosome undetermined scaffold_27, wh... 36 0.70
UniRef50_Q601R9 Cluster: Putative uncharacterized protein; n=3; ... 35 1.2
UniRef50_Q4DB33 Cluster: Poly(ADP-ribose) polymerase, putative; ... 35 1.6
UniRef50_Q2GML6 Cluster: Putative uncharacterized protein; n=3; ... 33 3.7
UniRef50_Q3YPH2 Cluster: Cathepsin L-like cysteine proteinase; n... 33 6.5
>UniRef50_P09874 Cluster: Poly [ADP-ribose] polymerase 1 (EC
2.4.2.30) (PARP-1) (ADPRT) (NAD(+)
ADP-ribosyltransferase 1); n=54; Eumetazoa|Rep: Poly
[ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT)
(NAD(+) ADP-ribosyltransferase 1) - Homo sapiens (Human)
Length = 1014
Score = 75.8 bits (178), Expect = 7e-13
Identities = 38/77 (49%), Positives = 53/77 (68%), Gaps = 4/77 (5%)
Frame = +2
Query: 2 EEKTENRWKDRNNFVKIPGRYFPLEIDYGDNE--TKTLTVDP--KCELAEPVQRLIVTIF 169
EEKT N W +N F K P +++PLEIDYG +E K LTV+P K +L +PVQ LI IF
Sbjct: 619 EEKTGNAWHSKN-FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIF 677
Query: 170 DIHYMKQTLLEFELDTE 220
D+ MK+ ++E+E+D +
Sbjct: 678 DVESMKKAMVEYEIDLQ 694
Score = 61.3 bits (142), Expect = 2e-08
Identities = 26/56 (46%), Positives = 41/56 (73%)
Frame = +1
Query: 256 KAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
+A Y +LSE+Q + G +S ++I+D +NRF+TLIPHDFG+ PLL+N + ++ K
Sbjct: 707 QAAYSILSEVQQAVSQG-SSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAK 761
>UniRef50_Q4RR03 Cluster: Chromosome 14 SCAF15003, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF15003, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 841
Score = 74.1 bits (174), Expect = 2e-12
Identities = 36/77 (46%), Positives = 50/77 (64%), Gaps = 4/77 (5%)
Frame = +2
Query: 2 EEKTENRWKDRNNFVKIPGRYFPLEIDYGDNETK----TLTVDPKCELAEPVQRLIVTIF 169
+EKT N W +NF K P +++PLEIDYG +E T T K +LA+PVQ LI IF
Sbjct: 361 KEKTGNDWSS-SNFTKYPNKFYPLEIDYGQDEEAVKKLTATAGTKSKLAKPVQELIKMIF 419
Query: 170 DIHYMKQTLLEFELDTE 220
D+ MK+ ++EFE+D +
Sbjct: 420 DVESMKKAMVEFEIDLQ 436
Score = 47.2 bits (107), Expect = 3e-04
Identities = 19/34 (55%), Positives = 26/34 (76%)
Frame = +1
Query: 322 KIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
+I+D +NRF+TLIPHDFG+ PLL N + I+ K
Sbjct: 497 QILDLSNRFYTLIPHDFGMKKPPLLSNLDYIQAK 530
>UniRef50_UPI00015B52AF Cluster: PREDICTED: similar to
poly(ADP-ribose) polymerase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to poly(ADP-ribose)
polymerase - Nasonia vitripennis
Length = 999
Score = 70.5 bits (165), Expect = 3e-11
Identities = 32/75 (42%), Positives = 53/75 (70%), Gaps = 2/75 (2%)
Frame = +2
Query: 2 EEKTENRWKDRNNFVKIPGRYFPLEIDYGDNET--KTLTVDPKCELAEPVQRLIVTIFDI 175
+EKT N W +R++FVK+P + P++ID+G +ET K L + + +L +PVQ L+ IFD+
Sbjct: 603 KEKTGNSWSERDSFVKMPNKMHPIDIDHGVDETVEKILESNVESKLNKPVQDLMRLIFDV 662
Query: 176 HYMKQTLLEFELDTE 220
MK+ +LE+E+D +
Sbjct: 663 ESMKRAMLEYEIDMD 677
Score = 44.8 bits (101), Expect = 0.002
Identities = 20/54 (37%), Positives = 35/54 (64%), Gaps = 1/54 (1%)
Frame = +1
Query: 265 YKVLSELQNLIKSGD-ASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
Y VL+EL LI + D +++++ A+N+F+TLIPH FG+ ++ + I+ K
Sbjct: 693 YSVLTELLALINNDDNPEQSQLIAASNKFYTLIPHSFGLEGPKIIKTEKEIQAK 746
>UniRef50_Q7Z115 Cluster: NAD(+) ADP-ribosyltransferase-1A; n=2;
Dictyostelium discoideum|Rep: NAD(+)
ADP-ribosyltransferase-1A - Dictyostelium discoideum
(Slime mold)
Length = 938
Score = 68.5 bits (160), Expect = 1e-10
Identities = 28/54 (51%), Positives = 41/54 (75%)
Frame = +1
Query: 262 GYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
GYKVLSE+Q+++ + + SRN ++D RF+TLIPH+FG APL+D ++IK K
Sbjct: 637 GYKVLSEIQDILNTANPSRNLLLDCATRFYTLIPHNFGNQTAPLIDTVDLIKAK 690
Score = 35.5 bits (78), Expect = 0.93
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 22/92 (23%)
Frame = +2
Query: 11 TENRWKDRNNFVKIPGRYFPLEIDYGDNE------------------TKTLT---VDPKC 127
T +W+DR F K+P +Y+ + +D G++E T T T ++PK
Sbjct: 531 TAQKWEDRYKFKKLPRKYYMISLDDGNDEEEEENLVETVLKRKKSETTTTSTSQEIEPKK 590
Query: 128 E-LAEPVQRLIVTIFDIHYMKQTLLEFELDTE 220
E L + V L+ +FD MK+ L +DTE
Sbjct: 591 EGLPQRVLDLVKLMFDPEMMKKQLQSMNVDTE 622
>UniRef50_UPI0000E4A1FC Cluster: PREDICTED: similar to Poly
[ADP-ribose] polymerase 1 (PARP-1) (ADPRT) (NAD(+)
ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase
1), partial; n=3; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Poly [ADP-ribose] polymerase 1
(PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1)
(Poly[ADP-ribose] synthetase 1), partial -
Strongylocentrotus purpuratus
Length = 975
Score = 62.1 bits (144), Expect = 9e-09
Identities = 28/54 (51%), Positives = 44/54 (81%)
Frame = +1
Query: 265 YKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTKT 426
Y+VL++LQ L+ + A R+ I+DA+N+F+TLIPH+FG+ + PLLD+ +II+ KT
Sbjct: 674 YRVLTDLQKLL-TDKAPRSGILDASNQFYTLIPHNFGLKSIPLLDSLDIIQAKT 726
Score = 53.2 bits (122), Expect = 4e-06
Identities = 28/75 (37%), Positives = 47/75 (62%), Gaps = 3/75 (4%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNETKTLTVD---PKCELAEPVQRLIVTIFDI 175
EKT N++ +N +K P ++FPL+I Y + E T + + +L + +Q L+ IFD+
Sbjct: 585 EKTGNKFGAKNP-IKHPMKFFPLDISYDEEERITSSKERAGKTSQLPKQIQSLMKMIFDL 643
Query: 176 HYMKQTLLEFELDTE 220
+K+T+LEFE+D E
Sbjct: 644 EELKKTMLEFEIDLE 658
>UniRef50_P35875-2 Cluster: Isoform I of P35875 ; n=2; Drosophila
melanogaster|Rep: Isoform I of P35875 - Drosophila
melanogaster (Fruit fly)
Length = 805
Score = 57.2 bits (132), Expect = 3e-07
Identities = 31/74 (41%), Positives = 45/74 (60%), Gaps = 2/74 (2%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNE--TKTLTVDPKCELAEPVQRLIVTIFDIH 178
+KT N ++ R+NFVK GR +P+EI Y D++ K + +L VQ LI IFDI
Sbjct: 414 DKTGNEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKHESHFFTSKLEISVQNLIKLIFDID 473
Query: 179 YMKQTLLEFELDTE 220
M +TL+EF +D +
Sbjct: 474 SMNKTLMEFHIDMD 487
Score = 53.6 bits (123), Expect = 3e-06
Identities = 22/54 (40%), Positives = 41/54 (75%)
Frame = +1
Query: 256 KAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIK 417
++ Y+V+ E+ N+++ G ++ K++DATNRF+TLIPH+FGV L++ ++ I+
Sbjct: 500 QSAYRVVKEIYNVLECG-SNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIE 552
>UniRef50_P35875 Cluster: Poly [ADP-ribose] polymerase (EC 2.4.2.30)
(PARP) (ADPRT) (NAD(+) ADP- ribosyltransferase); n=9;
Endopterygota|Rep: Poly [ADP-ribose] polymerase (EC
2.4.2.30) (PARP) (ADPRT) (NAD(+) ADP-
ribosyltransferase) - Drosophila melanogaster (Fruit
fly)
Length = 994
Score = 57.2 bits (132), Expect = 3e-07
Identities = 31/74 (41%), Positives = 45/74 (60%), Gaps = 2/74 (2%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNE--TKTLTVDPKCELAEPVQRLIVTIFDIH 178
+KT N ++ R+NFVK GR +P+EI Y D++ K + +L VQ LI IFDI
Sbjct: 603 DKTGNEYEQRDNFVKRTGRMYPIEIQYDDDQKLVKHESHFFTSKLEISVQNLIKLIFDID 662
Query: 179 YMKQTLLEFELDTE 220
M +TL+EF +D +
Sbjct: 663 SMNKTLMEFHIDMD 676
Score = 53.6 bits (123), Expect = 3e-06
Identities = 22/54 (40%), Positives = 41/54 (75%)
Frame = +1
Query: 256 KAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIK 417
++ Y+V+ E+ N+++ G ++ K++DATNRF+TLIPH+FGV L++ ++ I+
Sbjct: 689 QSAYRVVKEIYNVLECG-SNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIE 741
>UniRef50_UPI00005A2C99 Cluster: PREDICTED: similar to Poly
[ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+)
ADP-ribosyltransferase-1) (Poly[ADP-ribose]
synthetase-1); n=1; Canis lupus familiaris|Rep:
PREDICTED: similar to Poly [ADP-ribose] polymerase-1
(PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1)
(Poly[ADP-ribose] synthetase-1) - Canis familiaris
Length = 357
Score = 55.6 bits (128), Expect = 8e-07
Identities = 31/77 (40%), Positives = 48/77 (62%), Gaps = 4/77 (5%)
Frame = +2
Query: 2 EEKTENRWKDRNNFVKIPGRYFPLEIDYGDNE--TKTLTV--DPKCELAEPVQRLIVTIF 169
EEKT N W +N +K P +++ LEID+G ++ K LTV K + + VQ LI IF
Sbjct: 54 EEKTGNAWHAKN-IMKHPQKFYLLEIDFGQDKEAVKKLTVKSSTKSKFPKLVQDLIKMIF 112
Query: 170 DIHYMKQTLLEFELDTE 220
D+ MK+ ++E+E+D +
Sbjct: 113 DVESMKKAMVEYEIDLQ 129
Score = 39.1 bits (87), Expect = 0.075
Identities = 16/37 (43%), Positives = 23/37 (62%)
Frame = +1
Query: 313 SRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
S + I+D +N F TLIPHDF + P L N + ++ K
Sbjct: 144 SPSSILDLSNHFCTLIPHDFEMKKPPFLSNADCVQAK 180
>UniRef50_A7TC91 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 241
Score = 55.6 bits (128), Expect = 8e-07
Identities = 26/56 (46%), Positives = 36/56 (64%)
Frame = +1
Query: 256 KAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
KAGY+ L ++++ I GD NK+V A + F+T IPH FG+ PLL NE +K K
Sbjct: 95 KAGYEALKKIESCISKGDYG-NKLVKACDEFYTRIPHCFGMKRPPLLRTNEEVKEK 149
Score = 41.9 bits (94), Expect = 0.011
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 8/80 (10%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNETKTLTVDPKCEL-AEP-------VQRLIV 160
+KT+N W+DR +F K+ G+Y L +DY E + K E A+P V+ L+
Sbjct: 3 DKTKNDWEDRASFTKVQGKYDLLIMDYKAEENDEVDAPVKEEKPAKPESKLDCRVRELVE 62
Query: 161 TIFDIHYMKQTLLEFELDTE 220
I ++ M++ L E + DT+
Sbjct: 63 LICNVQAMEEALKEMKYDTK 82
>UniRef50_A5AIW8 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 1016
Score = 52.8 bits (121), Expect = 6e-06
Identities = 28/76 (36%), Positives = 44/76 (57%), Gaps = 6/76 (7%)
Frame = +2
Query: 5 EKTEN---RWKDRNNFVKIPGRYFPLEIDYGDNE---TKTLTVDPKCELAEPVQRLIVTI 166
EKT N W+ + NF K PGR+FPL+IDYG N+ K + +LA V L+ +
Sbjct: 613 EKTGNPWEAWERKQNFQKQPGRFFPLDIDYGVNKQVSKKNNLSNVNSQLAPQVVELMKML 672
Query: 167 FDIHYMKQTLLEFELD 214
F++ + ++EFE++
Sbjct: 673 FNVETYRSAMMEFEIN 688
Score = 37.9 bits (84), Expect = 0.17
Identities = 20/38 (52%), Positives = 28/38 (73%), Gaps = 4/38 (10%)
Frame = +1
Query: 262 GYKVLSELQNLIKSG--DAS--RNKIVDATNRFFTLIP 363
G++ L+E+QNL+ S D S + IVDA+NRFFT+IP
Sbjct: 705 GFEALTEIQNLLNSNAHDPSFKESLIVDASNRFFTVIP 742
>UniRef50_A0DM45 Cluster: Chromosome undetermined scaffold_56, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_56,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 599
Score = 51.6 bits (118), Expect = 1e-05
Identities = 23/63 (36%), Positives = 39/63 (61%)
Frame = +1
Query: 235 KVV*ETKKAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEII 414
K+ T K G+ VL ++Q+ + + + ++ T+ F++ IPHDFG+N APL+D E +
Sbjct: 292 KLAATTIKKGFDVLKQIQDELDKKNKNVVELQRLTSEFYSQIPHDFGMNKAPLIDTKEKV 351
Query: 415 KTK 423
K K
Sbjct: 352 KAK 354
>UniRef50_Q9N4H4 Cluster: Poly(ADP-ribose) polymerase pme-1; n=2;
Caenorhabditis|Rep: Poly(ADP-ribose) polymerase pme-1 -
Caenorhabditis elegans
Length = 945
Score = 51.6 bits (118), Expect = 1e-05
Identities = 27/73 (36%), Positives = 42/73 (57%), Gaps = 3/73 (4%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNETKT---LTVDPKCELAEPVQRLIVTIFDI 175
EKT+N W R +F K+PG + +E DY + T +T K L + V+ ++++IFD+
Sbjct: 544 EKTKNDWIYRKHFRKMPGMFSYVETDYSEFAQITDTEITPGSKTLLPKSVKEVVMSIFDV 603
Query: 176 HYMKQTLLEFELD 214
MK L FE+D
Sbjct: 604 ENMKSALKSFEMD 616
Score = 41.5 bits (93), Expect = 0.014
Identities = 17/53 (32%), Positives = 35/53 (66%)
Frame = +1
Query: 265 YKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
++VL+++ +L+ ++I+D +N+F+T+IPH+FG+ +D+ IK K
Sbjct: 634 FEVLNDISDLLVKLPIDASRILDFSNKFYTIIPHNFGMRVPEPIDSFHKIKEK 686
>UniRef50_Q54CP3 Cluster: Poly(ADP-ribosyl)transferase; n=3;
Dictyostelium discoideum|Rep:
Poly(ADP-ribosyl)transferase - Dictyostelium discoideum
AX4
Length = 700
Score = 51.2 bits (117), Expect = 2e-05
Identities = 32/85 (37%), Positives = 45/85 (52%), Gaps = 15/85 (17%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDY--------GDNETKTLTVDPK-------CELAE 139
EKT+N + DR NF K+ G+Y +E+DY G + T T T K C L E
Sbjct: 306 EKTKNTFTDRANFKKVAGKYDMIELDYSTDSKPKNGASTTATTTTTKKVVEHKKECSLDE 365
Query: 140 PVQRLIVTIFDIHYMKQTLLEFELD 214
VQ L+ IFD+ M++T+ E + D
Sbjct: 366 RVQELVKLIFDVKMMERTMTEAKYD 390
Score = 41.1 bits (92), Expect = 0.019
Identities = 17/54 (31%), Positives = 36/54 (66%)
Frame = +1
Query: 262 GYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
GY VL ++++++ G S + ++RF+T+IPH FG++ P+++ N+++ K
Sbjct: 407 GYLVLKQIEDVM--GGKSGESLSTLSSRFYTIIPHAFGMSVPPVINTNQMLIEK 458
>UniRef50_Q9UGN5 Cluster: Poly [ADP-ribose] polymerase 2 (EC
2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2);
n=24; Eumetazoa|Rep: Poly [ADP-ribose] polymerase 2 (EC
2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) -
Homo sapiens (Human)
Length = 583
Score = 50.8 bits (116), Expect = 2e-05
Identities = 28/82 (34%), Positives = 47/82 (57%), Gaps = 10/82 (12%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDN-----ETK-----TLTVDPKCELAEPVQRL 154
+KT+N W+DR F K+PG+Y L++DY N ETK + P+ +L VQ L
Sbjct: 182 DKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQEL 241
Query: 155 IVTIFDIHYMKQTLLEFELDTE 220
I I ++ M++ ++E + +T+
Sbjct: 242 IKLICNVQAMEEMMMEMKYNTK 263
Score = 49.2 bits (112), Expect = 7e-05
Identities = 21/56 (37%), Positives = 36/56 (64%)
Frame = +1
Query: 256 KAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
KAGY+ L ++++ I++G R +++A N F+T IPHDFG+ PL+ + + K
Sbjct: 276 KAGYQSLKKIEDCIRAGQHGR-ALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEK 330
>UniRef50_Q9ZP54 Cluster: Poly [ADP-ribose] polymerase 1 (EC
2.4.2.30) (PARP-1) (ADPRT 1) (NAD(+)
ADP-ribosyltransferase 1); n=6; Magnoliophyta|Rep: Poly
[ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT
1) (NAD(+) ADP-ribosyltransferase 1) - Arabidopsis
thaliana (Mouse-ear cress)
Length = 983
Score = 50.8 bits (116), Expect = 2e-05
Identities = 26/75 (34%), Positives = 41/75 (54%), Gaps = 5/75 (6%)
Frame = +2
Query: 5 EKTENRWKD---RNNFVKIPGRYFPLEIDYGDNE--TKTLTVDPKCELAEPVQRLIVTIF 169
EKT N W+ + NF K PG++ PL+IDYG N+ K LA + L+ +F
Sbjct: 589 EKTGNTWESWEQKTNFQKQPGKFLPLDIDYGVNKQVAKKEPFQTSSNLAPSLIELMKMLF 648
Query: 170 DIHYMKQTLLEFELD 214
D+ + ++EFE++
Sbjct: 649 DVETYRSAMMEFEIN 663
Score = 35.1 bits (77), Expect = 1.2
Identities = 16/38 (42%), Positives = 25/38 (65%), Gaps = 4/38 (10%)
Frame = +1
Query: 262 GYKVLSELQNLIKSGDAS----RNKIVDATNRFFTLIP 363
G++ L+E+Q L+ D + +VDA+NRFFT+IP
Sbjct: 680 GFEALTEIQRLLTESDPQPTMKESLLVDASNRFFTMIP 717
>UniRef50_A0BXK8 Cluster: Chromosome undetermined scaffold_134,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_134,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 571
Score = 49.2 bits (112), Expect = 7e-05
Identities = 23/59 (38%), Positives = 37/59 (62%)
Frame = +1
Query: 247 ETKKAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
E K G+K+L+E+Q ++ D + +VD TN F+T IP ++G+ P +DN EI+ K
Sbjct: 262 EAIKKGFKILNEIQQALR--DFKYSLLVDLTNEFYTNIPQNYGMKLPPKIDNYEILGQK 318
>UniRef50_Q24FE8 Cluster: WGR domain containing protein; n=1;
Tetrahymena thermophila SB210|Rep: WGR domain containing
protein - Tetrahymena thermophila SB210
Length = 802
Score = 48.8 bits (111), Expect = 9e-05
Identities = 22/77 (28%), Positives = 45/77 (58%)
Frame = +1
Query: 193 LARIRVGHRENASRKVV*ETKKAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDF 372
L + +N ++ + + GYK+L+E+QN + G + + I++ TN+F+T IP ++
Sbjct: 302 LKELNFDTEKNPLGRLTFDQVQKGYKILTEIQNALLQGSRT-SIIIELTNQFYTNIPQNY 360
Query: 373 GVNNAPLLDNNEIIKTK 423
G+ P++D+ +K K
Sbjct: 361 GMRALPMIDHMTKVKEK 377
>UniRef50_Q5C0T7 Cluster: SJCHGC03992 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC03992 protein - Schistosoma
japonicum (Blood fluke)
Length = 204
Score = 46.0 bits (104), Expect = 7e-04
Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 5/74 (6%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYG-DNETKTL----TVDPKCELAEPVQRLIVTIF 169
+KT N+W++R +F+K G+Y +EIDYG +E T+ T + K L VQ L+ I
Sbjct: 122 DKTLNQWEERMHFIKHKGKYDLVEIDYGVQDENVTIETKKTEEIKSRLPVAVQVLMQLIC 181
Query: 170 DIHYMKQTLLEFEL 211
D+ M+Q + E +
Sbjct: 182 DMDNMEQVMTELNM 195
>UniRef50_Q9Y6F1 Cluster: Poly [ADP-ribose] polymerase 3 (EC
2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3);
n=36; Deuterostomia|Rep: Poly [ADP-ribose] polymerase 3
(EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase
3) - Homo sapiens (Human)
Length = 533
Score = 45.2 bits (102), Expect = 0.001
Identities = 29/85 (34%), Positives = 40/85 (47%), Gaps = 13/85 (15%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLE-------------IDYGDNETKTLTVDPKCELAEPV 145
EKT+N W +R++FV PG+Y +E +D G T T V P C L
Sbjct: 131 EKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQP-CSLDPAT 189
Query: 146 QRLIVTIFDIHYMKQTLLEFELDTE 220
Q+LI IF K T+ +LD +
Sbjct: 190 QKLITNIFSKEMFKNTMALMDLDVK 214
Score = 38.7 bits (86), Expect = 0.100
Identities = 14/54 (25%), Positives = 32/54 (59%)
Frame = +1
Query: 262 GYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
G++ L L+ +K + + ++ F+T+IPH+FG + P +++ E+++ K
Sbjct: 229 GFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAK 282
>UniRef50_UPI0000E48B4F Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 736
Score = 44.4 bits (100), Expect = 0.002
Identities = 25/80 (31%), Positives = 45/80 (56%), Gaps = 8/80 (10%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNETKTLT------VDPK--CELAEPVQRLIV 160
+KT+N W +R++FVK+ G+Y L++DY +T + PK +L VQ L+
Sbjct: 342 DKTKNEWMNRDSFVKVAGKYDQLKLDYNIKDTDVESSGDAKESKPKVPSKLDIRVQNLVS 401
Query: 161 TIFDIHYMKQTLLEFELDTE 220
I ++ M+ ++E + DT+
Sbjct: 402 LICNVKAMEDLVIEMKYDTQ 421
Score = 41.9 bits (94), Expect = 0.011
Identities = 18/56 (32%), Positives = 32/56 (57%)
Frame = +1
Query: 256 KAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
KAGY L +++ I+ G ++++ A + F+T IPH+FG+ P++ K K
Sbjct: 434 KAGYLALKQIEKCIE-GSIIGDQLIKACDAFYTRIPHNFGMQRPPVIQTKNEFKAK 488
>UniRef50_A2ZSW8 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (japonica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. japonica
(Rice)
Length = 562
Score = 44.4 bits (100), Expect = 0.002
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Frame = +1
Query: 262 GYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAP--LLDNNEIIKTK 423
GY VL + N+I D R ++ T F+++IPHDFG ++D + +K K
Sbjct: 290 GYDVLKRISNVISGADTDRTQLEQLTGEFYSVIPHDFGFKKMSEFIIDTPQKLKAK 345
>UniRef50_Q54X55 Cluster: Poly(ADP-ribosyl)transferase; n=2;
Dictyostelium discoideum|Rep:
Poly(ADP-ribosyl)transferase - Dictyostelium discoideum
AX4
Length = 804
Score = 43.2 bits (97), Expect = 0.005
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 12/84 (14%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDY--------GDNETKTLTVDP----KCELAEPVQ 148
+KT W DR + K G+Y ++++ GDNE + V P +L +PVQ
Sbjct: 382 DKTGIEWNDRGKYKKQNGKYAIIDLEENVGEFSSGGDNEVEAPIVAPVNTKPSKLLQPVQ 441
Query: 149 RLIVTIFDIHYMKQTLLEFELDTE 220
L+ T+FD MK++L + D +
Sbjct: 442 SLVNTLFDSELMKKSLTSLQFDVQ 465
>UniRef50_Q0V159 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 671
Score = 43.2 bits (97), Expect = 0.005
Identities = 18/53 (33%), Positives = 36/53 (67%), Gaps = 1/53 (1%)
Frame = +1
Query: 262 GYKVLSELQNLIKSGDA-SRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIK 417
G++ L +L ++ + DA SR K+ D +N ++++IPH FG P++ +N+++K
Sbjct: 356 GFQALKDLAAILDNTDADSRAKVEDLSNLYYSVIPHAFGRVRPPVIRDNDLLK 408
>UniRef50_UPI0000D9A214 Cluster: PREDICTED: poly (ADP-ribose)
polymerase family, member 3; n=2; Eutheria|Rep:
PREDICTED: poly (ADP-ribose) polymerase family, member 3
- Macaca mulatta
Length = 503
Score = 42.3 bits (95), Expect = 0.008
Identities = 27/85 (31%), Positives = 39/85 (45%), Gaps = 13/85 (15%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLE-------------IDYGDNETKTLTVDPKCELAEPV 145
EKT+N+W +R+ FV PG+Y +E +D G T V P C L
Sbjct: 130 EKTKNKWAERDRFVAHPGKYTLIEVQGEDEAQEAVVKVDGGPVRTVAKRVQP-CSLDPAT 188
Query: 146 QRLIVTIFDIHYMKQTLLEFELDTE 220
Q+L+ IF K T+ +LD +
Sbjct: 189 QKLVTNIFSKEMFKNTMALMDLDVK 213
Score = 38.7 bits (86), Expect = 0.100
Identities = 14/54 (25%), Positives = 32/54 (59%)
Frame = +1
Query: 262 GYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
G++ L L+ +K + + ++ F+T+IPH+FG + P +++ E+++ K
Sbjct: 228 GFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGRSRPPPINSPELLQAK 281
>UniRef50_A1DF96 Cluster: Poly(ADP)-ribose polymerase PARP,
putative; n=8; Trichocomaceae|Rep: Poly(ADP)-ribose
polymerase PARP, putative - Neosartorya fischeri (strain
ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 693
Score = 40.3 bits (90), Expect = 0.033
Identities = 21/66 (31%), Positives = 35/66 (53%), Gaps = 8/66 (12%)
Frame = +1
Query: 250 TKKAGYKVLSELQNLIKSGDASRNKI--------VDATNRFFTLIPHDFGVNNAPLLDNN 405
T G+++L +L L+ + ++ +D +NR+FT IPH FG N P+L +
Sbjct: 353 TLTTGFQILKDLSELVADPSLASSRYNTSFHFAALDLSNRYFTTIPHVFGRNTPPVLTKD 412
Query: 406 EIIKTK 423
IKT+
Sbjct: 413 HQIKTE 418
>UniRef50_Q22MT0 Cluster: WGR domain containing protein; n=2;
Tetrahymena thermophila SB210|Rep: WGR domain containing
protein - Tetrahymena thermophila SB210
Length = 502
Score = 37.5 bits (83), Expect = 0.23
Identities = 22/65 (33%), Positives = 37/65 (56%), Gaps = 2/65 (3%)
Frame = +1
Query: 235 KVV*ETKKAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAP--LLDNNE 408
K+ +T K Y VL+EL IK+ + S+ + + ++ F++ IPHDFG +L + E
Sbjct: 220 KLAEQTIKQAYLVLNELMEAIKNNETSQFERLSSS--FYSYIPHDFGFQKMSHFILRSEE 277
Query: 409 IIKTK 423
+K K
Sbjct: 278 QVKQK 282
>UniRef50_Q11207 Cluster: Poly [ADP-ribose] polymerase 2 (EC
2.4.2.30) (PARP-2) (ADPRT 2) (NAD(+)
ADP-ribosyltransferase 2); n=16; Eukaryota|Rep: Poly
[ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (ADPRT
2) (NAD(+) ADP-ribosyltransferase 2) - Arabidopsis
thaliana (Mouse-ear cress)
Length = 637
Score = 37.1 bits (82), Expect = 0.30
Identities = 15/31 (48%), Positives = 19/31 (61%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNE 97
+KT+N W DR F+ P Y LE+DYG E
Sbjct: 236 DKTKNYWSDRKEFIPHPKSYTWLEMDYGKEE 266
Score = 37.1 bits (82), Expect = 0.30
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Frame = +1
Query: 235 KVV*ETKKAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAP--LLDNNE 408
K+ T GY+VL + +I D R ++ + + F+T+IPHDFG ++D +
Sbjct: 324 KISKSTISKGYEVLKRISEVIDRYD--RTRLEELSGEFYTVIPHDFGFKKMSQFVIDTPQ 381
Query: 409 IIKTK 423
+K K
Sbjct: 382 KLKQK 386
>UniRef50_UPI00004998EE Cluster: poly(ADP-ribose) polymerase; n=2;
Entamoeba histolytica HM-1:IMSS|Rep: poly(ADP-ribose)
polymerase - Entamoeba histolytica HM-1:IMSS
Length = 845
Score = 36.7 bits (81), Expect = 0.40
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 5/65 (7%)
Frame = +1
Query: 235 KVV*ETKKAGYKVLSELQNLIKSGDASRNK-----IVDATNRFFTLIPHDFGVNNAPLLD 399
K+ E K +VLS+L +++ K I D T +++T +PH N P++D
Sbjct: 551 KIKIEQMKEAMRVLSKLSDILSKDSEMTEKQKEVQIKDLTAKYYTFVPHVINGNIIPMID 610
Query: 400 NNEII 414
N+E I
Sbjct: 611 NDEKI 615
Score = 36.3 bits (80), Expect = 0.53
Identities = 19/54 (35%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Frame = +2
Query: 2 EEKTENRWKDRNNFVKIPGRYFPLEIDYGDNET---KTLTVDPKCELAEPVQRL 154
+E T N W++R F K+ G+YF +D G +ET K + + K ++ E Q+L
Sbjct: 454 KECTGNEWENRLQFKKVGGKYFMQALDTGKDETERKKLINEETKKKMEEKRQQL 507
>UniRef50_Q24GE4 Cluster: WGR domain containing protein; n=2;
Tetrahymena thermophila SB210|Rep: WGR domain containing
protein - Tetrahymena thermophila SB210
Length = 626
Score = 36.7 bits (81), Expect = 0.40
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Frame = +1
Query: 247 ETKKAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAP--LLDNNEIIKT 420
E Y +L +L ++ +++KI + N F++ IPHDFG +LD+ + +K
Sbjct: 305 ENINKAYGMLKQLYEEVEKPKKNKDKIEELCNEFYSYIPHDFGFKKMASFILDDAKKVKE 364
Query: 421 K 423
K
Sbjct: 365 K 365
>UniRef50_A0CTW4 Cluster: Chromosome undetermined scaffold_27, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_27,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 542
Score = 35.9 bits (79), Expect = 0.70
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 4/63 (6%)
Frame = +1
Query: 247 ETKKAGYKVLSELQNLIKSGDASRNK----IVDATNRFFTLIPHDFGVNNAPLLDNNEII 414
ET K GY +L ++ I ++ K + ++ F++ IPH+ G + LD N+ I
Sbjct: 236 ETIKKGYSILKKIAEAINETKLTKQKKKCLLEGLSSEFYSYIPHNNGYSKLKSLDTNQDI 295
Query: 415 KTK 423
K K
Sbjct: 296 KEK 298
>UniRef50_Q601R9 Cluster: Putative uncharacterized protein; n=3;
Mycoplasma hyopneumoniae|Rep: Putative uncharacterized
protein - Mycoplasma hyopneumoniae (strain 232)
Length = 750
Score = 35.1 bits (77), Expect = 1.2
Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 2/61 (3%)
Frame = +1
Query: 247 ETKKAGYKVLSELQNLIKSGDASRNKIVDATNRFF--TLIPHDFGVNNAPLLDNNEIIKT 420
+TK+ G K SE QNL + GD N+IV+ + T+ + L+ N I+K
Sbjct: 539 KTKENGLKNTSETQNLDQKGDLETNEIVEEAEKSAEKTITTTELSTEKTEKLEENAIVKP 598
Query: 421 K 423
K
Sbjct: 599 K 599
>UniRef50_Q4DB33 Cluster: Poly(ADP-ribose) polymerase, putative;
n=5; Trypanosoma|Rep: Poly(ADP-ribose) polymerase,
putative - Trypanosoma cruzi
Length = 604
Score = 34.7 bits (76), Expect = 1.6
Identities = 16/53 (30%), Positives = 31/53 (58%)
Frame = +1
Query: 265 YKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
Y +L L+ IK + ++ + +++F+TLIPH FG PL+ + +++ K
Sbjct: 309 YSLLKSLEAEIKKANP---RLEELSDQFYTLIPHAFGRLRPPLISSESMLRQK 358
Score = 33.5 bits (73), Expect = 3.7
Identities = 14/31 (45%), Positives = 18/31 (58%)
Frame = +2
Query: 5 EKTENRWKDRNNFVKIPGRYFPLEIDYGDNE 97
+KT N W R F + GRY ++IDYG E
Sbjct: 210 QKTANHWGSRARFNAVKGRYELMDIDYGAAE 240
>UniRef50_Q2GML6 Cluster: Putative uncharacterized protein; n=3;
Sordariomycetes|Rep: Putative uncharacterized protein -
Chaetomium globosum (Soil fungus)
Length = 1409
Score = 33.5 bits (73), Expect = 3.7
Identities = 13/40 (32%), Positives = 25/40 (62%)
Frame = +1
Query: 304 GDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTK 423
G A + + +N F++LIPH FG N P++ + ++K++
Sbjct: 435 GMAYGSAVEQLSNTFYSLIPHAFGRNRPPVIGSQAMLKSE 474
>UniRef50_Q3YPH2 Cluster: Cathepsin L-like cysteine proteinase;
n=21; Bilateria|Rep: Cathepsin L-like cysteine
proteinase - Globodera pallida
Length = 379
Score = 32.7 bits (71), Expect = 6.5
Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 6/50 (12%)
Frame = -3
Query: 175 DVKDGDDESL------HGLGELTLGVDSECFRLIVTVVYFQREVSPRNLD 44
D+ +GD+E L G + + F+L VYF++E SP NLD
Sbjct: 275 DIAEGDEEKLKIAVATQGPASVAIDAGHRSFQLYTHGVYFEKECSPENLD 324
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 507,414,847
Number of Sequences: 1657284
Number of extensions: 8841629
Number of successful extensions: 19844
Number of sequences better than 10.0: 34
Number of HSP's better than 10.0 without gapping: 19431
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 19827
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 40658285374
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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