Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte9a09
(697 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 313 2e-84
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 313 3e-84
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 227 3e-58
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 209 4e-53
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 200 3e-50
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 195 1e-48
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 183 3e-45
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 179 7e-44
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 178 1e-43
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 173 3e-42
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 158 1e-37
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 151 1e-35
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 147 2e-34
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 146 5e-34
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 137 2e-31
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 136 6e-31
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 123 5e-27
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 115 1e-24
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 113 5e-24
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 111 2e-23
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 110 3e-23
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 107 2e-22
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 107 2e-22
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 106 4e-22
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 103 6e-21
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 102 7e-21
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 100 7e-20
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 98 2e-19
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 97 5e-19
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 94 3e-18
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 94 3e-18
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 89 1e-16
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 89 1e-16
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 88 2e-16
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 85 2e-15
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 82 1e-14
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 81 2e-14
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 81 3e-14
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 74 3e-12
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 73 5e-12
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 73 7e-12
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 73 9e-12
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 72 1e-11
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 71 2e-11
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 69 1e-10
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 68 3e-10
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 66 1e-09
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 65 2e-09
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 65 2e-09
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 63 5e-09
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 62 1e-08
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 62 1e-08
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 62 2e-08
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 62 2e-08
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 62 2e-08
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 60 4e-08
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 59 1e-07
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 58 3e-07
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 57 4e-07
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 57 4e-07
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 57 5e-07
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 57 5e-07
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 56 6e-07
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 56 1e-06
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 55 2e-06
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 54 3e-06
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 54 3e-06
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 54 3e-06
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 52 1e-05
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 52 1e-05
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 52 2e-05
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 51 2e-05
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 47 3e-05
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 51 3e-05
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 51 3e-05
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 50 7e-05
UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;... 48 2e-04
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 47 5e-04
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 47 5e-04
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 47 5e-04
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 46 7e-04
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 46 7e-04
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 46 9e-04
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 46 0.001
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 46 0.001
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 45 0.002
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 44 0.004
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 43 0.006
UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1; Plesiocy... 43 0.008
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 43 0.008
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 42 0.011
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 42 0.019
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 42 0.019
UniRef50_Q5FK36 Cluster: Putative ATPase; n=1; Lactobacillus aci... 41 0.033
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 38 0.24
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 37 0.41
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 36 0.72
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 36 1.3
UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata D... 35 1.7
UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66; ... 35 1.7
UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular organ... 35 2.2
UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, who... 35 2.2
UniRef50_Q08KN2 Cluster: FIg-Hepta; n=3; Takifugu rubripes|Rep: ... 34 2.9
UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4; Vibrionales|... 34 2.9
UniRef50_O32147 Cluster: Probable xanthine dehydrogenase subunit... 34 2.9
UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3; Achol... 34 2.9
UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7; G... 34 3.8
UniRef50_A0DT58 Cluster: Chromosome undetermined scaffold_62, wh... 34 3.8
UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenas... 33 5.1
UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2; Roseovar... 33 5.1
UniRef50_Q8IC48 Cluster: Putative uncharacterized protein PF07_0... 33 5.1
UniRef50_Q6C705 Cluster: Similar to DEHA0E18414g Debaryomyces ha... 33 5.1
UniRef50_A3BGI7 Cluster: Putative uncharacterized protein; n=1; ... 33 6.7
UniRef50_UPI000065D57A Cluster: Putative polypeptide N-acetylgal... 33 8.8
UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces pomb... 33 8.8
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 313 bits (769), Expect = 2e-84
Identities = 144/201 (71%), Positives = 172/201 (85%), Gaps = 3/201 (1%)
Frame = +2
Query: 104 DVQHKTPVIRKQKL---IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 274
DV H ++K+ IP AQYGGRHAVTMLPGGGIGPE MGYVR+IF+Y GAPIDFEV
Sbjct: 32 DVAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEV 91
Query: 275 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 454
+DIDP+ + +DD+ YAIT+IKRNGV LKGNIETKS++ SRNVA+RNELD+Y +++C
Sbjct: 92 IDIDPSTEGNDDLDYAITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELDLYVNVVHC 151
Query: 455 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFA 634
KSYPG+ RH DIDVV+IRQNT+GEYAMLEHESV G+VESMKVVT +N+ERVAR+AFEFA
Sbjct: 152 KSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFA 211
Query: 635 KKNGRKKVTTVHKANIMKLSD 697
++N RKKVTT+HKANIMKLSD
Sbjct: 212 RQNNRKKVTTIHKANIMKLSD 232
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 313 bits (768), Expect = 3e-84
Identities = 141/201 (70%), Positives = 171/201 (85%)
Frame = +2
Query: 95 SDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 274
S F++QHK P+ RK + IPKA YGGRH VTMLPGGGIGPE M YV+++F++ G P+DFEV
Sbjct: 24 SAFELQHKNPLQRKVEKIPKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEV 83
Query: 275 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 454
VDIDP + +DD++YAIT+IKRNGV LKGNIETKSEA + SRNVALRNELD+Y +L+C
Sbjct: 84 VDIDPASEGNDDLEYAITSIKRNGVALKGNIETKSEATGIISRNVALRNELDLYVNVLHC 143
Query: 455 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFA 634
KS+ + H+++DVVIIRQNTEGEYAMLEHESV GVVESMKVVT +N+ RVAR+AFEFA
Sbjct: 144 KSFNAIPAHHQNVDVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFA 203
Query: 635 KKNGRKKVTTVHKANIMKLSD 697
+ N RKKVTT+HKANIMKL+D
Sbjct: 204 RANNRKKVTTIHKANIMKLAD 224
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 227 bits (554), Expect = 3e-58
Identities = 108/199 (54%), Positives = 144/199 (72%), Gaps = 4/199 (2%)
Frame = +2
Query: 113 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI 283
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V +
Sbjct: 32 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV 91
Query: 284 DPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYV-TSRNVALRNELDMYAYILNCKS 460
D ++D++ AI I+RN V LKGNIET SRN LR LD+YA +++CKS
Sbjct: 92 SSNAD-EEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKS 150
Query: 461 YPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKK 640
PGV TRHKDID++I+R+NTEGEY+ LEHESV GVVES+K++T S R+A +AF+ A++
Sbjct: 151 LPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQE 210
Query: 641 NGRKKVTTVHKANIMKLSD 697
+GRKKVT VHKANIMKL D
Sbjct: 211 SGRKKVTAVHKANIMKLGD 229
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 209 bits (511), Expect = 4e-53
Identities = 101/189 (53%), Positives = 140/189 (74%), Gaps = 6/189 (3%)
Frame = +2
Query: 149 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD-----V 313
P A+YGGR+ VT++PG GIGPE + V+DIF++IG P+DFE +++ D+D
Sbjct: 43 PPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAF 102
Query: 314 QYAITTIKRNGVGLKGNIETKSEAAY-VTSRNVALRNELDMYAYILNCKSYPGVATRHKD 490
AIT+IKRNGV +KGNI T +A S N+ LR LD++A I+ CKS PG+ TRH +
Sbjct: 103 NEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQTRHNN 162
Query: 491 IDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 670
+D+VIIRQNTEGEY+ LEHE+V+GV+E++KV T + ++A++AF+FA+K+ RKKVT VH
Sbjct: 163 VDLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQYAFDFAEKHDRKKVTAVH 222
Query: 671 KANIMKLSD 697
KANIMK+ D
Sbjct: 223 KANIMKMGD 231
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 200 bits (488), Expect = 3e-50
Identities = 102/187 (54%), Positives = 135/187 (72%)
Frame = +2
Query: 137 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 316
++L+PK +YGGR+ VT++PG G+G E V IF+ PID+E +DI ++N ++VQ
Sbjct: 19 EQLLPK-KYGGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISG-LENTENVQ 76
Query: 317 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 496
A+ ++KRN VGLKG T ++ S NVALR +LD++A + KS PGV TR +ID
Sbjct: 77 RAVESLKRNKVGLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNID 136
Query: 497 VVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKA 676
+VIIR+NTEGEY+ LEHESV GVVES+K++T SER+ARFAF+FA KN RK V VHKA
Sbjct: 137 MVIIRENTEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKA 196
Query: 677 NIMKLSD 697
NIMKL D
Sbjct: 197 NIMKLGD 203
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 195 bits (475), Expect = 1e-48
Identities = 99/187 (52%), Positives = 132/187 (70%)
Frame = +2
Query: 137 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 316
++ +PK +YGGR VT++PG G+G E VR IF+ PID+E ++I T D+ + V
Sbjct: 18 ERTLPK-KYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQT-DHKEGVY 75
Query: 317 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 496
A+ ++KRN +GLKG T ++ S NVALR +LD+YA + KS GV TR DID
Sbjct: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDID 135
Query: 497 VVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKA 676
+++IR+NTEGE++ LEHESV GVVES+KV+T +ER+ARFAF+FAKK RK VT VHKA
Sbjct: 136 LIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKA 195
Query: 677 NIMKLSD 697
NIMKL D
Sbjct: 196 NIMKLGD 202
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 183 bits (446), Expect = 3e-45
Identities = 89/188 (47%), Positives = 132/188 (70%), Gaps = 5/188 (2%)
Frame = +2
Query: 149 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE---VVDIDPTMDNDDDVQY 319
P A G R T++PG G+GPE + ++++FK P+DFE + +++P + ++
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAK--LED 89
Query: 320 AITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDI 493
I +I++N V +KG + T S + S N+ LRNELD+YA +++ +S PGV TR++DI
Sbjct: 90 VIASIRKNKVCIKGVLATPDYSNVGELQSLNMKLRNELDLYANVVHARSLPGVKTRYQDI 149
Query: 494 DVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 673
D+V+IR+ TEGEY+ LEHESV G+VE +K++TA S R+A+FAF++A KN RKKVT+VHK
Sbjct: 150 DIVVIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTSVHK 209
Query: 674 ANIMKLSD 697
ANIMKL D
Sbjct: 210 ANIMKLGD 217
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 179 bits (435), Expect = 7e-44
Identities = 92/193 (47%), Positives = 128/193 (66%)
Frame = +2
Query: 119 TPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMD 298
T + R +P+ G VT++PG GIGP G V + + + AP+ FE ++ M
Sbjct: 21 TSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMR 80
Query: 299 NDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT 478
+ I ++KRN V LKG + T V+S N+ LR ELD++A ++NC + PG+ T
Sbjct: 81 KVPEE--VIESVKRNKVCLKGGLATPVGGG-VSSLNMQLRKELDIFASLVNCINVPGLVT 137
Query: 479 RHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKV 658
RH+++D+V+IR+NTEGEY+ LEHE V GVVES+KV+T SER+AR+AFE+A N RKKV
Sbjct: 138 RHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKV 197
Query: 659 TTVHKANIMKLSD 697
T VHKANIMKL+D
Sbjct: 198 TAVHKANIMKLAD 210
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 178 bits (433), Expect = 1e-43
Identities = 92/189 (48%), Positives = 126/189 (66%)
Frame = +2
Query: 131 RKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD 310
R +P+ G AVT++PG GIGP V + + + API FE D+ M
Sbjct: 24 RSVTYMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEMSRVPP 83
Query: 311 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 490
+ +I++N V LKG ++T V+S NV LR ELD++A ++NC + PG+ TRH++
Sbjct: 84 E--VMESIRKNKVCLKGGLKTPVGGG-VSSLNVQLRKELDLFASLVNCFNLPGLPTRHEN 140
Query: 491 IDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 670
+D+V+IR+NTEGEYA LEHE V GVVES+KV+T SER+A++AFE+A N RKKVT VH
Sbjct: 141 VDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVH 200
Query: 671 KANIMKLSD 697
KANIMKL+D
Sbjct: 201 KANIMKLAD 209
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 173 bits (422), Expect = 3e-42
Identities = 82/180 (45%), Positives = 122/180 (67%), Gaps = 3/180 (1%)
Frame = +2
Query: 167 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 340
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 341 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 517
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 518 TEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
TEGEY+ LEHES GV+E +K+VT S+R+A+FAF++A K GR KVT VHKANIMKL D
Sbjct: 167 TEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGD 226
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 158 bits (383), Expect = 1e-37
Identities = 84/181 (46%), Positives = 114/181 (62%), Gaps = 3/181 (1%)
Frame = +2
Query: 164 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTI 334
G VT++PG GIGPE V+ IF+ API ++ VD+ P D + I +
Sbjct: 22 GDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELM 81
Query: 335 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 514
N VGLKG +ET + S N+A+R E +YA + C+S G T + ++DVV IR+
Sbjct: 82 HANKVGLKGPLETPIGKGH-RSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRE 140
Query: 515 NTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLS 694
NTEGEY+ +EHE V GVV+S+K++T S VA FAFE+A++NGRK VT VHKANIM+ S
Sbjct: 141 NTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKANIMRQS 200
Query: 695 D 697
D
Sbjct: 201 D 201
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 151 bits (367), Expect = 1e-35
Identities = 70/163 (42%), Positives = 107/163 (65%), Gaps = 1/163 (0%)
Frame = +2
Query: 110 QHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDP 289
Q P + + P A+YGGRH VT++PG GIGPE + +VR++F++ P+DFEVV ++
Sbjct: 30 QRGKPTYSGRIIPPPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS 89
Query: 290 TMDNDDDVQYAITTIKRNGVGLKGNIETK-SEAAYVTSRNVALRNELDMYAYILNCKSYP 466
+ ++DD+ AI I+RNGV LKGNIET + SRN LR LD+YA +++C+S P
Sbjct: 90 SSTSEDDISNAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLP 149
Query: 467 GVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTAD 595
GV TRHK+ID++II + +E + E+E + + +++ AD
Sbjct: 150 GVQTRHKNIDIIIILEKSEFSALLAENEKIKVELLQLRIQLAD 192
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 147 bits (357), Expect = 2e-34
Identities = 83/210 (39%), Positives = 119/210 (56%), Gaps = 3/210 (1%)
Frame = +2
Query: 77 AAPATLSDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGA 256
A PA +S V K + + GG VT++PG GIGPE V IF A
Sbjct: 2 AGPAWISK--VSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKA 59
Query: 257 PIDFEVVDIDPTMDNDDDVQY---AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNEL 427
PI +E ++ A ++ +N +GLKG ++T A + S N+ LR
Sbjct: 60 PIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGH-PSMNLLLRKTF 118
Query: 428 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSER 607
D+YA + C S G T + D+++V IR+NTEGEY+ +EH V+GVV+S+K++T S+R
Sbjct: 119 DLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKR 178
Query: 608 VARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
+A FAFE+A+ N R VT VHKANIM++SD
Sbjct: 179 IAEFAFEYARNNHRSNVTAVHKANIMRMSD 208
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 146 bits (354), Expect = 5e-34
Identities = 77/176 (43%), Positives = 111/176 (63%), Gaps = 4/176 (2%)
Frame = +2
Query: 182 TMLPGGGIGPECMGYVRDIFKYIGAPIDFEV----VDIDPTMDNDDDVQYAITTIKRNGV 349
T+ PG GIGPE V+ +F ID++ ++DP N + ++ +N V
Sbjct: 47 TLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRT-NSFLTWDNLQSVLKNKV 105
Query: 350 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 529
GLKG + T + S N+ LR EL++YA + C S PG TR+ D+D++ IR+NTEGE
Sbjct: 106 GLKGPMATPIGKGH-RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGE 164
Query: 530 YAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
Y+ LEH+ V GVVES+K++T S RVA +AF +AK +GRKKV+ +HKANIM+ +D
Sbjct: 165 YSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTD 220
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 137 bits (332), Expect = 2e-31
Identities = 68/178 (38%), Positives = 111/178 (62%), Gaps = 3/178 (1%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE--VVDIDPTMDNDDDVQYAIT-TIKRN 343
+ +T++PG GIGPE + + G ++E + + + + +I+R
Sbjct: 3 YKITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERT 62
Query: 344 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 523
+GLKG + T + +S NV LR ++YA + ++ PGV TR+ +D+V++R+NTE
Sbjct: 63 RIGLKGPVTTPIGGGF-SSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTE 121
Query: 524 GEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
G Y+ +EHE V GVVES+K++T S R+++FAF +A+K GRKK+ ++HKANIMK+SD
Sbjct: 122 GLYSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIHSIHKANIMKMSD 179
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 136 bits (328), Expect = 6e-31
Identities = 71/179 (39%), Positives = 108/179 (60%), Gaps = 2/179 (1%)
Frame = +2
Query: 167 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV--QYAITTIKR 340
G++ V+ + G GIGPE V+ IF PI++E D+ P N A+ +I +
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITK 94
Query: 341 NGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNT 520
N V LKG + T + S N+ LR ++A + KS G T ++++D+V+IR+NT
Sbjct: 95 NLVALKGPLATPIGKGH-RSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENT 153
Query: 521 EGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
EGEY+ +EH GVV+S+K++T D SERV R+AFE+A+ GR +V VHK+ I +L+D
Sbjct: 154 EGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLAD 212
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 123 bits (296), Expect = 5e-27
Identities = 61/173 (35%), Positives = 103/173 (59%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 358
VT++ G G+G E M V+++ + API+++V D D+DD + +++ N VG+K
Sbjct: 72 VTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPEVLKSLRANKVGIK 131
Query: 359 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 538
G ++++ + R + +AY+ C G+ + + D DVVIIR EG+Y+
Sbjct: 132 GPVDSRHWQRQI-------RKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSG 184
Query: 539 LEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
+EH V GV++++KV T + R+A F F +A KN RK++T HKANIM+++D
Sbjct: 185 IEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTD 237
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 115 bits (277), Expect = 1e-24
Identities = 65/183 (35%), Positives = 103/183 (56%), Gaps = 6/183 (3%)
Frame = +2
Query: 167 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV----QYAITTI 334
GR +T++PG GIGPEC+ + + AP+ +EV + ++ Q I +I
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77
Query: 335 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRH--KDIDVVII 508
++ V LKG +ET S NV LR + YA + + +P V T + + ID+V++
Sbjct: 78 RKTRVVLKGPLETPVGYGE-KSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVV 136
Query: 509 RQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMK 688
R+N E YA +EH V +++K+++ SE++ RFAFE A+ GRKKV K+NIMK
Sbjct: 137 RENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMK 196
Query: 689 LSD 697
L++
Sbjct: 197 LAE 199
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 113 bits (271), Expect = 5e-24
Identities = 50/95 (52%), Positives = 69/95 (72%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTA 592
L LD+YA +++ K+ P V T HKD+D++++ +NTEGEY+ LEHESV GV ES+K++T
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 593 DNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
S R+A +AF+ A+K G KKV VHK NI KL D
Sbjct: 62 AKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGD 96
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 111 bits (267), Expect = 2e-23
Identities = 54/138 (39%), Positives = 86/138 (62%), Gaps = 3/138 (2%)
Frame = +2
Query: 167 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 340
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 341 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 517
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 518 TEGEYAMLEHESVNGVVE 571
TEGEY+ LEHE V E
Sbjct: 167 TEGEYSSLEHECCEEVAE 184
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 110 bits (265), Expect = 3e-23
Identities = 70/179 (39%), Positives = 95/179 (53%), Gaps = 6/179 (3%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRN 343
VT+ G GIGPE M V + K P+ E ++I + N Y IT I R
Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKY-YTYGITEDTWSQIFRT 65
Query: 344 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYIL-NCKSYPGVATRHKDIDVVIIRQNT 520
LKG + T Y S NV LR L +YA + +C +P V T +IDVVIIR+N
Sbjct: 66 KALLKGPVTTPQGGGY-KSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENE 124
Query: 521 EGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
E YA +E+ ES+K+++ SE++ RFAFE+A KN RK ++ K NIMK +D
Sbjct: 125 EDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTD 183
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 107 bits (258), Expect = 2e-22
Identities = 67/178 (37%), Positives = 94/178 (52%), Gaps = 5/178 (2%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ----YAITTIKRNG 346
+T+ G G+GPE M V I K A + E VDI + A +I R
Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTR 69
Query: 347 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTE 523
+ LK T + + S NVALR L +Y + C SY P V T+H D+DVVIIR+N E
Sbjct: 70 LLLKAPTMTPQGSGH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEE 128
Query: 524 GEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
Y+ +EH+ E +K+ T SE++ +AF +A+ + RKKVT K NIMK++D
Sbjct: 129 DTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKMTD 186
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 107 bits (258), Expect = 2e-22
Identities = 69/200 (34%), Positives = 107/200 (53%), Gaps = 25/200 (12%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV-----QYAITTIK 337
+ VT++PG GIGPE + + + G +D E + ++ ++ + + +I+
Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEASG--VDLEWIRVEAGVEVIEKYGTPLPPQVLESIR 60
Query: 338 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 517
V +KG I T + S NVA+R ELD+YA + KS PG+ + +DID+V++R+N
Sbjct: 61 ETRVAIKGPIGTPVGTGF-RSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVREN 119
Query: 518 TEGEYAMLEHES--------------------VNGVVESMKVVTADNSERVARFAFEFAK 637
TE YA +E E G +K ++ S R+ +FAFE+A+
Sbjct: 120 TEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYAR 179
Query: 638 KNGRKKVTTVHKANIMKLSD 697
+NGRKKVT VHKANIMK +D
Sbjct: 180 QNGRKKVTAVHKANIMKFTD 199
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 106 bits (255), Expect = 4e-22
Identities = 67/198 (33%), Positives = 110/198 (55%), Gaps = 23/198 (11%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTIKRN 343
+ VT++ G GIGPE R + G ++ VVD + I ++ +
Sbjct: 4 YRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRAS 63
Query: 344 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 523
+KG I T + + + S NVALR LD+YA + ++ PGV +R+ +ID+V++R+NTE
Sbjct: 64 DAAIKGPITTPAGSG-IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTE 122
Query: 524 GEYAMLEHESVN----GVVE----------------SMKVVTADNSERVARFAFEFAKKN 643
Y+ +E E + V+E ++K ++++ SER+ARFAFE+A+++
Sbjct: 123 DLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYARRH 182
Query: 644 GRKKVTTVHKANIMKLSD 697
R+KVT VHKANI+K +D
Sbjct: 183 ARRKVTAVHKANILKHTD 200
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 103 bits (246), Expect = 6e-21
Identities = 63/178 (35%), Positives = 96/178 (53%), Gaps = 5/178 (2%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV----QYAITTIKRNG 346
+T+ G GIGPE M V I + A I E +++ + + + +I+R G
Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66
Query: 347 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTE 523
+ LK I T Y S NV +R L ++A I S+ P T H +++ IIR+N E
Sbjct: 67 IILKAPITTPQGGGY-KSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENEE 125
Query: 524 GEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
YA +E+ + + ES+K+++ E++ R+AFE+A KN RKKVT + K NIMK SD
Sbjct: 126 DLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSD 183
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 102 bits (245), Expect = 7e-21
Identities = 62/179 (34%), Positives = 99/179 (55%), Gaps = 9/179 (5%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT-MDNDDDV--QYAITTIKRNGV 349
VT++PG GIGPE + V +F +G P +E ++ D+ Q + +I R G+
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQTTLDSIGRTGL 71
Query: 350 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTEG 526
LKG + T + S NV LR +YA + ++ PG R++ ID+V++R+N EG
Sbjct: 72 ALKGPLSTPIGGGF-RSVNVRLRETFQLYANVRPARTIVPG--GRYEKIDLVLVRENLEG 128
Query: 527 EYAMLEH-----ESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMK 688
Y EH + + V + + T S R+++FAF++A +N R+KVT VHKAN++K
Sbjct: 129 LYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRKVTIVHKANVLK 187
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 99.5 bits (237), Expect = 7e-20
Identities = 46/90 (51%), Positives = 65/90 (72%)
Frame = +2
Query: 428 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSER 607
D+ A ++ +S P V TRHK+ID++++R NTEGEY+ LE ES+N VVES++ VT R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 608 VARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
+A +AF+ A + G KKVT +KANIM+L D
Sbjct: 77 LAEYAFQLAHRMGCKKVTATYKANIMRLGD 106
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 97.9 bits (233), Expect = 2e-19
Identities = 66/180 (36%), Positives = 99/180 (55%), Gaps = 7/180 (3%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDF-EVVDIDPTMDNDDDV--QYAITTIK 337
V ++ G GIGPE + + I I PI++ EV D + + + ++ I
Sbjct: 5 VALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKIID 64
Query: 338 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 517
+ + LKG + AA V V LR DMYA I KS PG+ T++ ++D++I+R+N
Sbjct: 65 KADIILKGPVG--ESAADVV---VKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVREN 119
Query: 518 TEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
TE Y EH +GV MK++T SER+A+ FA + RKKVT VHKAN+M+++D
Sbjct: 120 TEDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALRR-RKKVTCVHKANVMRITD 178
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 96.7 bits (230), Expect = 5e-19
Identities = 60/159 (37%), Positives = 92/159 (57%), Gaps = 2/159 (1%)
Frame = +2
Query: 227 VRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRN 406
V + + AP+ FE I N + + +I++N V L G + S
Sbjct: 16 VHQVMDAMQAPVYFETYIIKGKNMNHLTWE-VVDSIRKNKVCLNGRVNN--------SLC 66
Query: 407 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKV- 583
R ELD++A +++C + G +RH+++D+V+IR+NTEGEYA EHE V GV+ES +V
Sbjct: 67 GGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVT 126
Query: 584 VTADNSERVARFAFEFAKKNGRKKVTTVH-KANIMKLSD 697
+T S+R+A++AFE+A + RKKVT VH KL+D
Sbjct: 127 MTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLAD 165
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 93.9 bits (223), Expect = 3e-18
Identities = 56/173 (32%), Positives = 87/173 (50%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 358
+ ++PG GIG E M I + ++F D T++ G
Sbjct: 6 IAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEARA 65
Query: 359 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 538
E+A V LR E D++A + KS PGV + D+D VI+R+NTE Y
Sbjct: 66 TLFGAAGESA--ADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDLYVG 123
Query: 539 LEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
E + G V + +++T S R+++FAF++A+K G +KVT VHKAN++K +D
Sbjct: 124 DEEYTPEGAV-AKRIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTD 175
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 93.9 bits (223), Expect = 3e-18
Identities = 57/174 (32%), Positives = 92/174 (52%), Gaps = 4/174 (2%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI-DPTMDNDDDV--QYAITTIKRNGV 349
+ ++PG GIG E M I + + P ++ D D ++ + +++
Sbjct: 4 IVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRKSDA 63
Query: 350 GLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG 526
L G ET ++ V LR EL +A + K+ G+ + +D+V++R+NTE
Sbjct: 64 VLFGAAGETAADVI------VRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTEC 117
Query: 527 EYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMK 688
Y E V E+++V+T + SER+AR+AFE AK+ GRKKVT +HKAN+MK
Sbjct: 118 LYMGFEF-GFGDVTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMK 170
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 89.0 bits (211), Expect = 1e-16
Identities = 69/189 (36%), Positives = 97/189 (51%), Gaps = 14/189 (7%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVG 352
H + ++ G GIG E + + + G P +F + D+V KR G
Sbjct: 2 HKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAG------DEVY------KRTGKA 49
Query: 353 L-KGNIETKSE-------AAYVTSRNVA--LRNELDMYAYILNCKSYPGVATRHKDIDVV 502
L + IET + AA T+ +V LR+ LD YA I K+Y GV DID V
Sbjct: 50 LPEETIETALDCDAVLFGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYV 109
Query: 503 IIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFA---KKNGRK-KVTTVH 670
I+R+NTEG Y +E E G+ + +V+T ER+ RFAF A KK G++ KVT H
Sbjct: 110 IVRENTEGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAH 169
Query: 671 KANIMKLSD 697
KAN++KL+D
Sbjct: 170 KANVLKLTD 178
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 88.6 bits (210), Expect = 1e-16
Identities = 59/183 (32%), Positives = 100/183 (54%), Gaps = 8/183 (4%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPID--FEVVDI---DPTMDNDDDV--QYAITT 331
+ ++++ G GIGPE + + I +D F + + D ++ ++
Sbjct: 2 YKISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSA 61
Query: 332 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 511
IK++ +K + AA V V LR LD+YA I KSYP + DID+VI+R
Sbjct: 62 IKQSDACMKAPVG--ESAADVI---VVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVR 116
Query: 512 QNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAK-KNGRKKVTTVHKANIMK 688
+NTE Y E S+ ++++++ S+R+A++AFE AK +N +KKVT VHK+N+M+
Sbjct: 117 ENTEDLYTGKEF-SLGDSSVALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNVMR 175
Query: 689 LSD 697
++D
Sbjct: 176 VTD 178
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 88.2 bits (209), Expect = 2e-16
Identities = 50/176 (28%), Positives = 97/176 (55%), Gaps = 1/176 (0%)
Frame = +2
Query: 143 LIPKAQYGGRHAVTMLPGGGI-GPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 319
++PK++YGG + V+++ G I G + +V + P++ +V++ DD+ +
Sbjct: 53 VLPKSKYGGINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEAG----QDDEYFH 108
Query: 320 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDV 499
++ RN + + + +EA + + + N+LD+Y + +S+PG R +D+
Sbjct: 109 SVL---RNRTAVHVDNQADAEAK---QKALKICNDLDLYVFKTRTRSFPGFKCRFPGVDI 162
Query: 500 VIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTV 667
+I QN G + LE+ V GVVE++ VV+ +++ R+AF+ A K GRK+VT +
Sbjct: 163 QLIGQNNMGIFNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 84.6 bits (200), Expect = 2e-15
Identities = 63/203 (31%), Positives = 103/203 (50%), Gaps = 28/203 (13%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID-PTMDNDDDV-QYAITTIKRNG 346
+ VT++PG G+GPE R G ID++V + ++ + V + +I+ N
Sbjct: 2 YKVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANK 61
Query: 347 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD--IDVVIIRQNT 520
+ LK I T + S NV LR EL +YA I CK+Y GV T D +D+V++R+NT
Sbjct: 62 IALKAPITTPIGKGF-RSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENT 120
Query: 521 EGEYAMLEHES--------------------VNGVVE----SMKVVTADNSERVARFAFE 628
E YA +E ++ +N ++ S+K ++ + + +AF+
Sbjct: 121 EDLYAGVEFQAGQEKTAELIKKINEFATGKKINTPLDETGVSIKPMSYQGTRDICNYAFK 180
Query: 629 FAKKNGRKKVTTVHKANIMKLSD 697
+A N R+ VT++ KANIMK +D
Sbjct: 181 YAVDNKRQSVTSICKANIMKFTD 203
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 82.2 bits (194), Expect = 1e-14
Identities = 46/119 (38%), Positives = 77/119 (64%), Gaps = 4/119 (3%)
Frame = +2
Query: 353 LKGNIE-TKSEAAYVT--SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 523
L G I T+++ + VT S N A+R EL+++ + Y G++ RH+ +D+VI+R+ TE
Sbjct: 73 LHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEKMDMVIMREITE 132
Query: 524 GEYAMLEHESVNGVV-ESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
Y E +G E++K VT S +V+++AFE+A+K+GRKKV+ +HKAN++ +D
Sbjct: 133 DTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANVLHETD 191
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 81.4 bits (192), Expect = 2e-14
Identities = 58/184 (31%), Positives = 97/184 (52%), Gaps = 11/184 (5%)
Frame = +2
Query: 170 RHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD--IDPTMDNDDDVQYA-ITTIKR 340
+H + ++PG GIG E M +F+ + PI + VD I + V I +K+
Sbjct: 10 QHKIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQ 69
Query: 341 NGVGLKGNI-ETKSEAAYVTSRN-VALRNELDMYAYILNCKSYPGVATRHK--DIDVVII 508
L G++ + ++ YVT + +R +LD + + K +PG+ T K +IDV+++
Sbjct: 70 YDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVV 129
Query: 509 RQNTEGEYAMLEHESVNGVVESMKVVTADNS----ERVARFAFEFAKKNGRKKVTTVHKA 676
R+N+EGEY+ + +G E + +A +S ERV R+AFE ++K R VT K+
Sbjct: 130 RENSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFEASRKR-RNHVTLATKS 188
Query: 677 NIMK 688
N MK
Sbjct: 189 NAMK 192
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 81.0 bits (191), Expect = 3e-14
Identities = 38/85 (44%), Positives = 55/85 (64%), Gaps = 3/85 (3%)
Frame = +2
Query: 113 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI 283
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V +
Sbjct: 5 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV 64
Query: 284 DPTMDNDDDVQYAITTIKRNGVGLK 358
D ++D+ AI I+RN V LK
Sbjct: 65 SSNAD-EEDICNAIMAIRRNRVALK 88
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 74.1 bits (174), Expect = 3e-12
Identities = 35/71 (49%), Positives = 50/71 (70%)
Frame = +2
Query: 485 KDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTT 664
K+ID+VIIR+NTE Y E N + +V+T SER+ RFAFE+A KN RKKV+
Sbjct: 120 KNIDIVIIRENTEDLYVGRERLE-NDTAIAERVITRKGSERIIRFAFEYAIKNNRKKVSC 178
Query: 665 VHKANIMKLSD 697
+HKAN+++++D
Sbjct: 179 IHKANVLRITD 189
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 73.3 bits (172), Expect = 5e-12
Identities = 36/105 (34%), Positives = 63/105 (60%), Gaps = 3/105 (2%)
Frame = +2
Query: 167 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID--PTMDNDDDVQYAITTIKR 340
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 74
Query: 341 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGV 472
N V + G I T E + S ++ LR +LD++A +++ KS PGV
Sbjct: 75 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVIHVKSLPGV 119
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 72.9 bits (171), Expect = 7e-12
Identities = 45/131 (34%), Positives = 72/131 (54%), Gaps = 5/131 (3%)
Frame = +2
Query: 320 AITTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 490
A+ +K+ V LKG + T + + S NVA+R ELD++A + V+ +
Sbjct: 75 ALDALKKCHVILKGPLTTPKKGDPWPNLESANVAMRRELDLFANVRP------VSIPSEG 128
Query: 491 IDVVIIRQNTEGEYAMLEH--ESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTT 664
ID V R+NTEGEY + + + KV+T SER+ R AF++A++N +V+
Sbjct: 129 IDWVFFRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNINRVSV 188
Query: 665 VHKANIMKLSD 697
V KAN++K +D
Sbjct: 189 VTKANVVKTTD 199
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 72.5 bits (170), Expect = 9e-12
Identities = 44/175 (25%), Positives = 84/175 (48%), Gaps = 5/175 (2%)
Frame = +2
Query: 185 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRNGV 349
++ G G+GPE + + + G ++F + + + + + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVPDETWQILDSSDA 66
Query: 350 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 529
KG T S V++R + D+YA + K++P D+++V +R+ TEG
Sbjct: 67 CFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGTEGL 126
Query: 530 YAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLS 694
Y E + + V +++ +T S ++AR+AFE AK+ G V +HK+NI+KL+
Sbjct: 127 YIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPIHKSNILKLT 181
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 72.1 bits (169), Expect = 1e-11
Identities = 57/185 (30%), Positives = 96/185 (51%), Gaps = 13/185 (7%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDFEVVDI-DPTMDNDDDV--QYAITTIK 337
V ++ G GIGPE +G + + I P++F V+ D + + + + +
Sbjct: 4 VAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEFVFVEAGDRAKEKYGEALPKESYERLL 63
Query: 338 RNGVGLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 514
R LKG + ET ++ V LR ELD++A I K PGV +++D++I+R+
Sbjct: 64 RADAILKGPVGETAADVI------VRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRE 117
Query: 515 NTEGEYA----MLEHESV-NGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKAN 679
N E Y +L S+ + V +++ + + RVA+ A E+AK R KVT VHKAN
Sbjct: 118 NIEDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEYAKAR-RNKVTIVHKAN 176
Query: 680 IMKLS 694
+M+++
Sbjct: 177 VMRVT 181
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 71.3 bits (167), Expect = 2e-11
Identities = 59/203 (29%), Positives = 90/203 (44%), Gaps = 18/203 (8%)
Frame = +2
Query: 143 LIPKAQYGGR-HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 319
+ P Q+ G + +LPG GIGPE + + + + + + Q+
Sbjct: 2 IAPALQFWGNVMQLIVLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQF 61
Query: 320 AITT------IKRNGVGL----KGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPG 469
T I R GL + K EA + + R LD+YA + ++Y G
Sbjct: 62 GTTVRPELLDIVRGADGLILGPTATFDFKDEAHGEINPSRHFRKNLDLYANVRPARTYAG 121
Query: 470 VATRHKDIDVVIIRQNTEGEYAMLEHESVNG-------VVESMKVVTADNSERVARFAFE 628
R D D+V++R+NTEG YA E NG V S++ +T ER+A A
Sbjct: 122 RPGRLGDFDLVVVRENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACR 181
Query: 629 FAKKNGRKKVTTVHKANIMKLSD 697
A K R+ +T VHKAN++K+ D
Sbjct: 182 LAMKR-RRHLTIVHKANVLKIGD 203
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 68.9 bits (161), Expect = 1e-10
Identities = 51/154 (33%), Positives = 79/154 (51%), Gaps = 26/154 (16%)
Frame = +2
Query: 314 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RH 484
Q + TIK + +KG + T + S NVALR ELD++ + + + GV + R
Sbjct: 76 QETLETIKEYLIAVKGPLTTPIGGG-IRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRP 134
Query: 485 KDIDVVIIRQNTEGEYAMLEHE----SVNGVVE-------------------SMKVVTAD 595
+D+D+VI R+NTE YA +E + V V++ +K V+ +
Sbjct: 135 EDVDMVIFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKE 194
Query: 596 NSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
+ER+ R A ++A N RK VT VHK NIMK ++
Sbjct: 195 GTERLVRAAIQYALDNNRKSVTLVHKGNIMKFTE 228
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 67.7 bits (158), Expect = 3e-10
Identities = 57/185 (30%), Positives = 87/185 (47%), Gaps = 16/185 (8%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIG--APIDFEVVDI----DPTMDNDDDV-QYAITTIK 337
+ ++PG GIG E + + K + + + FE + + + + + +AI K
Sbjct: 5 IAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIEEFK 64
Query: 338 RNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVATRHKD---IDVV 502
+ G I + R + L R ELD+Y + K Y T K ID+V
Sbjct: 65 KFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDIV 124
Query: 503 IIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 670
+R+NTEG YA L + + + T ERV RFAFE+AK++GRKKVT V
Sbjct: 125 FVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKVTLVD 184
Query: 671 KANIM 685
KAN++
Sbjct: 185 KANVL 189
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 65.7 bits (153), Expect = 1e-09
Identities = 40/106 (37%), Positives = 64/106 (60%)
Frame = +2
Query: 380 EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVN 559
E+AY + + +R L YA I K+ PGV ++ID V +R+N E Y E++ V
Sbjct: 41 ESAYDVTSLIRMRYTL--YANIRPVKNLPGVPAV-REIDCVFVRENVEDVYVGAEYK-VG 96
Query: 560 GVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
V ++KV+T + RVAR A ++A+ R++VT VHKAN++++ D
Sbjct: 97 DVAIALKVITEKGTRRVARMARKYAEMR-RRRVTIVHKANVLRVVD 141
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 64.9 bits (151), Expect = 2e-09
Identities = 35/100 (35%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG-------EYAMLEHESVNGVVE 571
LR D++A + +SYPG+ DID+VI+R+N EG E V
Sbjct: 95 LRKGFDLFANVRPTRSYPGIGCLFDDIDLVIVRENNEGFQPDRNVVAGSGEFRPTEDVTI 154
Query: 572 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKL 691
S++V+T + +V R A + A+ RKK+T VHK + KL
Sbjct: 155 SVRVITVEGCRKVVRAALDIARSRPRKKLTLVHKNTVFKL 194
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 64.9 bits (151), Expect = 2e-09
Identities = 54/176 (30%), Positives = 86/176 (48%), Gaps = 3/176 (1%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYA---ITTIKRNGV 349
+ +LPG GIG E + ++ K +F V++ + V + + T+K
Sbjct: 3 IAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKACDC 62
Query: 350 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 529
L G I + Y S + LR ELD+YA I +S P ++ R ++ I R+N+E
Sbjct: 63 VLFGAITSPPGKPY-RSIILTLRKELDLYANIRPFRSCP-ISPR--KVNFTIYRENSEDL 118
Query: 530 YAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
Y +E E S++V+T SER+AR A K G K+T VHK+N++K +
Sbjct: 119 YMGIE-EITGDEARSVRVITRKASERIARAA---CSKPGIGKLTIVHKSNVLKADE 170
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 63.3 bits (147), Expect = 5e-09
Identities = 39/101 (38%), Positives = 58/101 (57%), Gaps = 7/101 (6%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNG-------VVE 571
+R D++A I +S GVA+ D+D+VI+R+NTEG YA + +G V
Sbjct: 102 VRKRFDLFANIRPARSLEGVASTVPDMDLVIVRENTEGLYADRNMFAGSGEFMPTPDVAL 161
Query: 572 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLS 694
++ VVT ER+A AF A+ GR VT VHKAN++ ++
Sbjct: 162 AVGVVTRKACERIAHTAFALARTRGR-HVTIVHKANVLSMT 201
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 62.5 bits (145), Expect = 1e-08
Identities = 42/98 (42%), Positives = 52/98 (53%), Gaps = 7/98 (7%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTEGEYA----MLEHESVNGVVE 571
LR LD+Y + K Y T K ID+V IR+NTEG YA L + + V
Sbjct: 91 LRFSLDLYVNLRPVKLYHPKLTPLKGKEKIDMVFIRENTEGLYAGAGGFLRKGTPHEVAI 150
Query: 572 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 685
+ T ER RFAFE+AK GRKKVT V KAN++
Sbjct: 151 QEMINTRFGVERTIRFAFEYAKTKGRKKVTLVDKANVL 188
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 62.5 bits (145), Expect = 1e-08
Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 9/102 (8%)
Frame = +2
Query: 416 RNELDMYAYILNCKSYPGV----ATRHK-DIDVVIIRQNTEGEYAMLE----HESVNGVV 568
R E D Y I + +PGV A R DID V++R+NTEGEY+ L + N +V
Sbjct: 98 RREFDQYVNIRPVRLFPGVPCALANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIV 157
Query: 569 ESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLS 694
+ T +R+ ++AF+ A+K RK VT+ K+N M +S
Sbjct: 158 IQESIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAIS 199
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 61.7 bits (143), Expect = 2e-08
Identities = 60/203 (29%), Positives = 97/203 (47%), Gaps = 30/203 (14%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 358
+ +LP GIGPE +G ++ + + V +D D DD T++++ G L+
Sbjct: 3 ILVLPCDGIGPEIVGAAMEVLRSADS-----VFKLDLAFDYDD---VGFTSLEKYGTTLR 54
Query: 359 GNI------------ETKSEAAYVT----SRNVA--LRNELDMYAYILNCKSYPGVATRH 484
+ T+S A Y RNV+ R LD+YA + ++ P + +
Sbjct: 55 DEVLAKAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNM 114
Query: 485 KD---IDVVIIRQNTEGEYAMLEHESVNGVVE---------SMKVVTADNSERVARFAFE 628
++ +D+VI+R+ TEG Y + G E S++ +T SER+AR AFE
Sbjct: 115 REGRTMDLVIMREATEGFYP--DRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFE 172
Query: 629 FAKKNGRKKVTTVHKANIMKLSD 697
A K +KKVT +HKAN ++D
Sbjct: 173 LAMKR-KKKVTAIHKANSFHMTD 194
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 61.7 bits (143), Expect = 2e-08
Identities = 56/192 (29%), Positives = 82/192 (42%), Gaps = 19/192 (9%)
Frame = +2
Query: 167 GRHAVTMLPGGGIGPECMGYVRDIFKYIG-APIDFEVVDIDPTMDN--------DDDVQY 319
G + ++PG GIGPE + + A + FE D + D V
Sbjct: 130 GSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLPDSVLE 189
Query: 320 AIT---TIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---R 481
I I VG K N + LR ELD Y + + +PGVA+
Sbjct: 190 EIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPLAN 249
Query: 482 HKDIDVVIIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGR 649
++D V++R+ TEG Y L + + + + V TA ERV R AF A++ R
Sbjct: 250 PGEVDFVVVREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRRPR 309
Query: 650 KKVTTVHKANIM 685
KK+T VHK N++
Sbjct: 310 KKLTLVHKTNVL 321
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 61.7 bits (143), Expect = 2e-08
Identities = 52/179 (29%), Positives = 86/179 (48%), Gaps = 7/179 (3%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECM-------GYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT 331
+ V ++ G GIGPE + V D ++ FEV + ++DD++
Sbjct: 2 YRVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFEGGFEVFKRIGSPISEDDLK----E 57
Query: 332 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 511
I++ L G T S V LR ELD+YA N + P ++ ++VI+R
Sbjct: 58 IRKMDAILFGATTTPFNVPGYRSLIVTLRKELDLYA---NLRIIPDLSNGK---EIVIVR 111
Query: 512 QNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMK 688
+NTEG YA + + +++T + + R+A+FA AK+ +T VHKAN++K
Sbjct: 112 ENTEGLYAR-DGIGFSDRAIDFRIITLEGARRIAKFAINLAKER-NSFITFVHKANVLK 168
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 60.5 bits (140), Expect = 4e-08
Identities = 55/189 (29%), Positives = 87/189 (46%), Gaps = 17/189 (8%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI--DPTMDNDDDVQYAITTIKRNG 346
+ + ++PG GIG E + + + G P FE D + + + A T R
Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAA 65
Query: 347 VG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYI---LNCKSYPGVATRHKDIDVVIIR 511
L G + + A S V LR ELD+YA I + G R + +D+V++R
Sbjct: 66 DAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVR 125
Query: 512 QNTEGEYAMLEHESVNGVVE-SMKVVTADNSERVARFAFEFAK-----KNGRK----KVT 661
+NTE YA E +G + +V+T S R+ R A + A+ +NG +VT
Sbjct: 126 ENTEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSARNGSDAPPGRVT 185
Query: 662 TVHKANIMK 688
VHKAN+++
Sbjct: 186 VVHKANVLR 194
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 58.8 bits (136), Expect = 1e-07
Identities = 30/94 (31%), Positives = 58/94 (61%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTA 592
LR + ++YA + K+ P V ++++D+VI+R+NT+G Y E + + V+T
Sbjct: 89 LRQKYNLYANVRPTKTRP-VPHSYENVDLVIVRENTQGLYVEQERRYGDTAIAD-TVITR 146
Query: 593 DNSERVARFAFEFAKKNGRKKVTTVHKANIMKLS 694
+ S+R+ +FA + A K K++T VHK+N++ ++
Sbjct: 147 EASDRIGKFAADLAMKRS-KRLTVVHKSNVLPVT 179
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 57.6 bits (133), Expect = 3e-07
Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 11/105 (10%)
Frame = +2
Query: 407 VALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEYAMLEHESV--NGVVE 571
+ LR +LD++A + K Y GV + R ID VI+R+N+EG YA ++ V
Sbjct: 93 LTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDYVIVRENSEGLYAARGAGALLREEVAV 152
Query: 572 SMKVVTADNSERVARFAFEFAK------KNGRKKVTTVHKANIMK 688
V T ER+ RFAFE A+ K+GR++VT KAN+++
Sbjct: 153 DTLVQTRKGVERIVRFAFELARTRNGSPKDGRRRVTCCDKANVLR 197
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 57.2 bits (132), Expect = 4e-07
Identities = 24/37 (64%), Positives = 30/37 (81%)
Frame = +2
Query: 149 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAP 259
P A+YGGRH VTM+PG GIGPE M +V+ +F+Y GAP
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY-GAP 140
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 57.2 bits (132), Expect = 4e-07
Identities = 34/99 (34%), Positives = 51/99 (51%), Gaps = 3/99 (3%)
Frame = +2
Query: 323 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK---DI 493
+T IK GV +KG + T + S NVALR D+Y + C+ YPG + HK +
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGG-IRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKL 147
Query: 494 DVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERV 610
D+++ R+NTE Y L E G + K++ N E +
Sbjct: 148 DIIVYRENTEDIY--LGIEWAEGTEGAKKLIAYLNDELI 184
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 56.8 bits (131), Expect = 5e-07
Identities = 47/151 (31%), Positives = 73/151 (48%), Gaps = 26/151 (17%)
Frame = +2
Query: 323 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---I 493
++ I+ + V +KG + T A + S NVALR LD+YA + GV + K+ +
Sbjct: 131 VSAIRDHRVAIKGPLTTPVGAGF-RSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKM 189
Query: 494 DVVIIRQNTEGEYAMLEHESVNGVVE-----------------------SMKVVTADNSE 604
D++ R+NTE YA +E E+ VE +K ++ S+
Sbjct: 190 DMITFRENTEDVYAGIEWEAGTDEVEQVRDFLEDDMEIADVIHDGPVGIGVKPISEFGSK 249
Query: 605 RVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
R+ R A ++A N R VT VHK NIMK ++
Sbjct: 250 RLIREAIDYALANDRDSVTLVHKGNIMKFTE 280
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 56.8 bits (131), Expect = 5e-07
Identities = 48/191 (25%), Positives = 92/191 (48%), Gaps = 18/191 (9%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAP--IDFEVVDIDPTMDNDDDVQYA-----ITTIK 337
+ ++PG GIG E + + + + + + + F +D+ + A + +K
Sbjct: 26 IGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLK 85
Query: 338 RNGVG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 511
G L G +++ + + +S VALR E+ ++A + KS G + K ID+VI+R
Sbjct: 86 EQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG--EKGKPIDMVIVR 143
Query: 512 QNTEGEYAMLEHESVN-----GVVESMKVVTADNSERVARFAFEFAKK----NGRKKVTT 664
+NTE Y +E ++ V ++ K ++ + R+A A + A K G+ +T
Sbjct: 144 ENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALKRLQTRGQATLTV 203
Query: 665 VHKANIMKLSD 697
HK+N++ SD
Sbjct: 204 THKSNVLSQSD 214
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 56.4 bits (130), Expect = 6e-07
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 7/178 (3%)
Frame = +2
Query: 185 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTM---DNDDDVQY----AITTIKRN 343
++ G GIGPE + + + K + + + + D Y + ++
Sbjct: 7 VMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKILEET 66
Query: 344 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 523
KG T S V LR + D+YA I K+Y + T + +D V R+ TE
Sbjct: 67 DCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFREATE 125
Query: 524 GEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
G Y +E + + +++ +T S R+ A ++A K KK+ V K NI+K +D
Sbjct: 126 GLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQTD 183
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 55.6 bits (128), Expect = 1e-06
Identities = 33/94 (35%), Positives = 47/94 (50%)
Frame = -1
Query: 685 HDVGFVNRCYLLPAVFLGEFEGEPGHPLRVVSCHHFH*LDHTIHGFVFQHSVFTFCVLSD 506
HD+G V+ L V LG+ + + G L H H L+HT VFQ +FTF V SD
Sbjct: 41 HDIGLVDGGDQLTVVLLGKVKCKLGDSLGFEPGHDLHRLNHTRVRLVFQSRIFTFSVFSD 100
Query: 505 NNNINVLMSGRNARVRFTVQYVSIHVQFVSESHI 404
+N L + +A F S ++QF S+ +I
Sbjct: 101 EGKVNALQTRLDAGNVFDQDQRSKNIQFFSQRNI 134
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 54.8 bits (126), Expect = 2e-06
Identities = 48/148 (32%), Positives = 72/148 (48%), Gaps = 23/148 (15%)
Frame = +2
Query: 323 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKD-I 493
+ IK V LKG + T Y S NV +R LD+YA + GV + +H + +
Sbjct: 85 LNAIKEFRVALKGPLTTPVGGGY-RSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKV 143
Query: 494 DVVIIRQNTEGEYAMLE-----HESVN---------GVVE------SMKVVTADNSERVA 613
+ VI R+NTE YA +E E++ GV +K ++ ++R+
Sbjct: 144 NFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLV 203
Query: 614 RFAFEFAKKNGRKKVTTVHKANIMKLSD 697
R A +A +N RK VT VHK NIMK ++
Sbjct: 204 RMAIRYAIENNRKSVTLVHKGNIMKYTE 231
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 54.4 bits (125), Expect = 3e-06
Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 20/194 (10%)
Frame = +2
Query: 173 HAVTMLPGGGIG----PECMGYVRDIFKYIGA-----PIDFEVVDIDPTMDN--DDDVQY 319
+ + ++PG GIG PE + + + + G PI++ D DD +
Sbjct: 6 YRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDWKT 65
Query: 320 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGV-----ATRH 484
++ + G G ET + + + R E D Y + + + GV +
Sbjct: 66 QLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKA 125
Query: 485 KDIDVVIIRQNTEGEYAMLEHESVNGV----VESMKVVTADNSERVARFAFEFAKKNGRK 652
DID +I+R+NTEGEY+ + G V V T +ERV +FAFE A++ K
Sbjct: 126 GDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRA-K 184
Query: 653 KVTTVHKANIMKLS 694
++T K+N + +S
Sbjct: 185 RLTVATKSNGIAIS 198
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 54.4 bits (125), Expect = 3e-06
Identities = 43/162 (26%), Positives = 76/162 (46%), Gaps = 28/162 (17%)
Frame = +2
Query: 296 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 475
D D Q I ++ + +KG + T + S NVALR E+D++ + K + +
Sbjct: 81 DGDWFPQETIQAVRACKIAIKGPLTTPLGGGF-RSLNVALRQEMDLFVNMRTIKGFSALP 139
Query: 476 TRHKD---IDVVIIRQNTEGEYAMLEHESVNGVVESMKV--------------------- 583
+ K+ ++ ++R ++E Y+ +E ++ G +ES K+
Sbjct: 140 SPLKNPFLTNITVLRDSSEDVYSGIEWQA--GSIESEKMLDFLCEEMGVTRLRFSQDCGI 197
Query: 584 ----VTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
++ + SER+ RFA FA N R VT VHK N++K +D
Sbjct: 198 GIKNISKEGSERLTRFALNFALNNNRDSVTFVHKGNVLKFTD 239
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 54.0 bits (124), Expect = 3e-06
Identities = 54/193 (27%), Positives = 88/193 (45%), Gaps = 15/193 (7%)
Frame = +2
Query: 155 AQYGGRHAVT---MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD---IDPTMDNDDDVQ 316
A+ G AVT ++PG GIGPE + D+ +G +++D D + + +
Sbjct: 11 ARAGSETAVTTIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALT 70
Query: 317 YA-ITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRNELDMY-----AYILNCKSYPGV 472
+ + I+ + L G + + +YV LR ELD+Y A + + + P
Sbjct: 71 GSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLR 130
Query: 473 ATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKV-VTADNSERVARFAFEFAKKNGR 649
+ ID VI+R+NTEG Y+ + + G E + V V V+R EFA R
Sbjct: 131 DPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSR-VLEFAFSAAR 189
Query: 650 KKVTTVHKANIMK 688
+ V V KAN ++
Sbjct: 190 RSVCLVDKANAVR 202
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 52.4 bits (120), Expect = 1e-05
Identities = 42/150 (28%), Positives = 69/150 (46%), Gaps = 25/150 (16%)
Frame = +2
Query: 323 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY--PGVATRHKDID 496
I I V +KG + T + S NVALR ++D+Y + + Y P + +D
Sbjct: 99 IEAINHYKVSIKGPLTTPIGEGF-RSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVD 157
Query: 497 VVIIRQNTEGEYAMLEHESVNGVVESM-----------------------KVVTADNSER 607
+VI R+N+E YA +E + + + + K ++ + +ER
Sbjct: 158 MVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTER 217
Query: 608 VARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
+ R A E+A N + VT VHK NIMK ++
Sbjct: 218 LVRKAIEYAIDNDKPSVTFVHKGNIMKYTE 247
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 52.0 bits (119), Expect = 1e-05
Identities = 29/76 (38%), Positives = 45/76 (59%), Gaps = 4/76 (5%)
Frame = +2
Query: 479 RHKDIDVVIIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNG 646
+ +DID++ IR+N+EGEYA L + VV V + +ER+ R+AFE A+K
Sbjct: 121 KREDIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIARKE- 179
Query: 647 RKKVTTVHKANIMKLS 694
RK +T++ K N + S
Sbjct: 180 RKSLTSISKGNALNYS 195
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 51.6 bits (118), Expect = 2e-05
Identities = 44/151 (29%), Positives = 72/151 (47%), Gaps = 26/151 (17%)
Frame = +2
Query: 323 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKD-I 493
+T I+ V +KG + T + S NVA+R LD+Y + + Y G + +H + +
Sbjct: 89 MTFIRDYHVAIKGPLMTPVGGG-IRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELV 147
Query: 494 DVVIIRQNTEGEYAMLE----HESVNGVVE-------------------SMKVVTADNSE 604
D+VI R+N+E YA +E N V+ +K V+ ++
Sbjct: 148 DMVIFRENSEDIYAGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGTQ 207
Query: 605 RVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
R+ R A ++ N RK +T VHK NIMK ++
Sbjct: 208 RLVRAALQYVIDNDRKSLTLVHKGNIMKFTE 238
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 51.2 bits (117), Expect = 2e-05
Identities = 42/104 (40%), Positives = 52/104 (50%)
Frame = -2
Query: 471 TPG*DLQFSM*AYMSSSFLRATLRDVT*AASLLVSMLPFSPTPFLLMVVIAYWTSSSLSI 292
TPG L + A +S+SFL AT D+ + V+ +PF+PT FL A T LS
Sbjct: 8 TPGMFLIKTNEAKISNSFLNATFNDLP-DDPVGVNKIPFNPTLFLFNDSTASATPVPLS- 65
Query: 291 VGSMSTTSKSIGAPMYLNMSRTYPMHSGPIPPPGSMVTA*RPPY 160
ST S S+G L M T + S PIP PG VT PPY
Sbjct: 66 KPETSTVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTVYLPPY 109
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 46.8 bits (106), Expect(2) = 3e-05
Identities = 24/58 (41%), Positives = 30/58 (51%)
Frame = +2
Query: 134 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDD 307
+Q + P A+YGG VTM PG G GPE M V P+DFE V + D +D
Sbjct: 3 QQTIPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSSNADEED 60
Score = 23.8 bits (49), Expect(2) = 3e-05
Identities = 8/20 (40%), Positives = 14/20 (70%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGV 472
+R LD+YA +++CK G+
Sbjct: 61 IRTSLDLYANVIHCKLGDGL 80
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 50.8 bits (116), Expect = 3e-05
Identities = 45/133 (33%), Positives = 62/133 (46%), Gaps = 21/133 (15%)
Frame = +2
Query: 350 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATR----HKDI------DV 499
G G + K S + R L++YA + K YPGV R HK I D+
Sbjct: 65 GTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDM 124
Query: 500 VIIRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAK-------KNG 646
VIIR+NTEG YA + G V +V+T E+V R AFE K K+G
Sbjct: 125 VIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGAPKDG 184
Query: 647 RKKVTTVHKANIM 685
+ +VT + K N++
Sbjct: 185 KLRVTAIIKDNVL 197
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 50.8 bits (116), Expect = 3e-05
Identities = 49/182 (26%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDV-QYAITTIKRNGV 349
+ ++ G GIGPE + + + A I+ +D+ + N + + + ++ +
Sbjct: 3 LAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREHDA 62
Query: 350 GLKGNIETK-SEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVATRHK---DIDVVIIR 511
L G I S V R + L R LD + + K Y GV + K +ID V++R
Sbjct: 63 ILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFVVVR 122
Query: 512 QNTEGEY----AMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKAN 679
+ TEG Y + + + V T +ERV R+AFE A+ R+ +T VHK N
Sbjct: 123 EGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELAQSR-RRHLTLVHKTN 181
Query: 680 IM 685
++
Sbjct: 182 VL 183
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 49.6 bits (113), Expect = 7e-05
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGVATR---HKDIDVVIIRQNTEGEYA----MLEHESVNGVVE 571
+R Y KS PG+++ DID VI R+N EGEY+ L + +
Sbjct: 94 IRKNFQQYVNFRPIKSLPGISSPLAGGNDIDFVIFRENAEGEYSDSGGRLYQQQPQEMTI 153
Query: 572 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKAN 679
++T E++ R A E+A+++G+ K+T+ K+N
Sbjct: 154 QNTIMTRIGIEKIVRAACEYAQQHGKTKLTSATKSN 189
>UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;
Bacteria|Rep: 3-isopropylmalate dehydrogenase - Brucella
melitensis
Length = 370
Score = 48.4 bits (110), Expect = 2e-04
Identities = 53/193 (27%), Positives = 84/193 (43%), Gaps = 25/193 (12%)
Frame = +2
Query: 185 MLPGGGIGPECMGYVRDIFKYIGAPID--FEV---------VDIDPTMDNDDDVQYAITT 331
+LPG GIGPE M VR + ++ + ++ FE D +D D++ A+
Sbjct: 8 LLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAISDADMEKALAA 67
Query: 332 IKRNGVGLKGNIETKSEAAYVTSRN--VALRNELDMYAYILNCKSYPGVATRH------- 484
G G + S V + LR ++ +YA + YP +A
Sbjct: 68 -DAVLFGAVGGPKWDSVPYEVRPEGGLLRLRKDMQLYANLRPAICYPALAHSSSLKPEVI 126
Query: 485 KDIDVVIIRQNTEGEYAMLEHESV---NGVVESMKVVTADNSE--RVARFAFEFAKKNGR 649
+ +D++I+R+ T G Y E + NG + D E R+A AFE A+ R
Sbjct: 127 EGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFELARTR-R 185
Query: 650 KKVTTVHKANIMK 688
KVT++ K N+MK
Sbjct: 186 NKVTSMEKRNVMK 198
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 46.8 bits (106), Expect = 5e-04
Identities = 29/96 (30%), Positives = 48/96 (50%), Gaps = 9/96 (9%)
Frame = +2
Query: 428 DMYAYILNCKSYPGVATRHK-----DIDVVIIRQNTEGEYAMLEHESVNG----VVESMK 580
D YA + + PG+ K D++ VI+R+N+EGEY+ + G +
Sbjct: 99 DQYANVRPTRILPGIDGPLKRCKPGDLNWVIVRENSEGEYSGVGGRVHQGHPIEAATDVS 158
Query: 581 VVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMK 688
++T ER+ RFAF A+ RK +T + K+N +
Sbjct: 159 ILTRAGVERIMRFAFRLAQSRPRKLLTVITKSNAQR 194
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 46.8 bits (106), Expect = 5e-04
Identities = 31/83 (37%), Positives = 48/83 (57%), Gaps = 3/83 (3%)
Frame = +2
Query: 347 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQN 517
VG+KG + T + S NVALR LD+Y + + + GV + R + +D+VI R+N
Sbjct: 95 VGIKGPLTTPVGRG-IRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMVIFREN 153
Query: 518 TEGEYAMLEHESVNGVVESMKVV 586
TE YA +E+ + G E+ KV+
Sbjct: 154 TEDIYAGIEYAA--GTPEAQKVL 174
Score = 34.7 bits (76), Expect = 2.2
Identities = 20/58 (34%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Frame = +2
Query: 533 AMLEHESVNGVVE---SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
++L + G VE +K V+ +ER+ A ++A + R+ VT VHK NIMK ++
Sbjct: 201 SLLGNGDGEGAVEVGIGIKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMKFTE 258
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 46.8 bits (106), Expect = 5e-04
Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 9/96 (9%)
Frame = +2
Query: 428 DMYAYILNCKSYPGVATRHK-----DIDVVIIRQNTEGEYAMLEHESVNGVVE----SMK 580
D YA + K PG+ + D+D VI+R+N+EGEY+ + G+ E +
Sbjct: 99 DQYANVRPTKILPGITPPLRNCGPGDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVA 158
Query: 581 VVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMK 688
+ T R+ R+AF+ A+ RK +T V K+N +
Sbjct: 159 IFTRVGVTRIMRYAFKLAQARPRKLLTVVTKSNAQR 194
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 46.4 bits (105), Expect = 7e-04
Identities = 52/191 (27%), Positives = 82/191 (42%), Gaps = 21/191 (10%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYI-GAPIDFEVVDIDPTMDNDDDVQYAIT--TIKR--- 340
+ ++PG GIGPE + ++ + G ++ D D A++ T++R
Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSEDAGADAFRRTGSAMSAATLERIRT 68
Query: 341 --NGVGLKGNIETKS----EAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKDID 496
+GV LKG + + LR LD YA + PGV R +D
Sbjct: 69 RYHGV-LKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVD 127
Query: 497 VVIIRQNTEGEYAMLEHESVNG-VVESMKVVTADNSERVARFAFEFAKK------NGRKK 655
VI+R+NTEG Y N ++T ERV AFE A + +G ++
Sbjct: 128 YVIVRENTEGLYLSRGRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTGAPADGVRR 187
Query: 656 VTTVHKANIMK 688
VT V K+N+++
Sbjct: 188 VTCVDKSNVLR 198
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 46.4 bits (105), Expect = 7e-04
Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Frame = +2
Query: 314 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK-- 487
Q + +K V +KG + T + S NVALR +LD+Y + + + GV + K
Sbjct: 88 QETLDAVKDYVVSIKGPLTTPVGGG-IRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKP 146
Query: 488 -DIDVVIIRQNTEGEYAMLEHESVNGVVESMKVV 586
D+D+ I R+N+E YA +E ++ G E+ KV+
Sbjct: 147 GDVDMTIFRENSEDIYAGIEWKA--GSPEATKVI 178
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 46.0 bits (104), Expect = 9e-04
Identities = 53/198 (26%), Positives = 88/198 (44%), Gaps = 30/198 (15%)
Frame = +2
Query: 194 GGGIGPECMGYVRDIFKYIGA----PIDFEVV---DIDPTMDNDDDVQYAITTIKRNGVG 352
G GIGPE M R + A I ++ + D + D + +I I V
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEILLGDRAEELKGDRFPEESIKAINDYRVL 83
Query: 353 LKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTE 523
LK + T + S NV +R LD+YA I K PG+ + K+ +++ I R+NT+
Sbjct: 84 LKAPLNTPVGKGF-KSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTD 142
Query: 524 GEYAMLEH----ESVNGVVESMK----VVTADNS------------ERVARFAFEFAKKN 643
Y E + + + +K + +D+S +R+ R A ++A N
Sbjct: 143 DLYLGYEWSYDTDEAKRIRKFLKDEFNIDISDDSGIGIKPMSRYKTQRITRLAVKYAMDN 202
Query: 644 GRKKVTTVHKANIMKLSD 697
KK+T +HK N+MK ++
Sbjct: 203 NLKKITIMHKGNVMKYTE 220
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 45.6 bits (103), Expect = 0.001
Identities = 34/103 (33%), Positives = 54/103 (52%), Gaps = 12/103 (11%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSYPGVATRHK-----DIDVVIIRQNTEGEY------AMLEHESVN 559
LR L +Y + + Y T K +ID V++R++TEG + A LE +
Sbjct: 96 LRERLQLYGGVRPIRLYHEADTPLKGHGPGEIDFVLVRESTEGLFYGRDAIADLEADEAT 155
Query: 560 GVVESMKVVTADNSERVARFAFEFA-KKNGRKKVTTVHKANIM 685
++ +T SERV R AFE A +++G+K VT + KAN++
Sbjct: 156 NLLR----ITRSASERVCRLAFETARRRDGKKTVTLIDKANVL 194
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 45.6 bits (103), Expect = 0.001
Identities = 35/109 (32%), Positives = 58/109 (53%), Gaps = 14/109 (12%)
Frame = +2
Query: 398 SRNVALRNELDMYAYILNCKSYPGVATRHKD-----IDVVIIRQNTEG-EYAMLEHES-- 553
S ++ LR+ +YA + K+YP R D ID+VI+R++TEG Y+ H+
Sbjct: 87 SPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRAAGIDLVILRESTEGLFYSAAAHKRSL 146
Query: 554 -VN-GVVESMKVVTADNSERVARFAFEFAKKNGRK----KVTTVHKANI 682
VN V+ + +T + ++ RFAF A+K + ++T V KAN+
Sbjct: 147 VVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRERGHPGRLTCVDKANV 195
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 44.8 bits (101), Expect = 0.002
Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 10/104 (9%)
Frame = +2
Query: 407 VALRNELDMYAYILNCKSYPGVATR-----HKDIDVVIIRQNTEGEYAMLEHESV-NGVV 568
+ LR D+YA + + PGV + + ID+V+IR++TEG +A + V +
Sbjct: 104 IELRFIFDLYAGVRPARLIPGVPSPIVGADTRGIDLVVIRESTEGLFASMGKGVVTHEDA 163
Query: 569 ESMKVVTADNSERVARFAFEF-AKKNGRKK---VTTVHKANIMK 688
V+T SER+ F+F A++ R K +T V KAN+ K
Sbjct: 164 RETMVITRRTSERLFEFSFRLAARRKARGKPGMLTCVDKANVFK 207
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 44.0 bits (99), Expect = 0.004
Identities = 52/199 (26%), Positives = 93/199 (46%), Gaps = 24/199 (12%)
Frame = +2
Query: 170 RHAVTMLPGGGIGPECMGYVRDIFKYIGA----PIDFEVVDIDPTMDNDDDV---QYAIT 328
R+ + +LPG GIGPE + +++ + G+ DF+ + + + V + T
Sbjct: 46 RYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLVGVPLPEETFT 105
Query: 329 TIKRNGVGLKGNIE----TKSEAAYVTSRNVA-LRNELDMYAYILNCKSYPGV---ATRH 484
K + L G I K+E + LR +L ++A + P + +T
Sbjct: 106 AAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLK 165
Query: 485 KDI----DVVIIRQNTEGEY-----AMLEHESVNGVVESMKVVTADNSERVARFAFEFAK 637
K++ D++I+R+ T G Y + +E+ V S ++ A +R+AR AFE A+
Sbjct: 166 KEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETAR 225
Query: 638 KNGRKKVTTVHKANIMKLS 694
K R K+ +V KAN++ S
Sbjct: 226 KR-RGKLCSVDKANVLDAS 243
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 43.2 bits (97), Expect = 0.006
Identities = 45/182 (24%), Positives = 73/182 (40%), Gaps = 21/182 (11%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAIT-------- 328
+ + +LPG G GPE + + G F + N Y T
Sbjct: 5 YKIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTT---EKEYYNWGGAHYLATGETLPADA 61
Query: 329 --TIKRNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVAT-----R 481
+ R+ L G I V + + L R +LD Y + K +PGV T +
Sbjct: 62 KEQLARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKK 121
Query: 482 HKDIDVVIIRQNTEGEY----AMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGR 649
+DID V++R+N+ G Y ++ ++ V + T +R +FAFE A+K
Sbjct: 122 PEDIDYVVVRENSGGVYTGMGGNVQIDTPEEVACQNWIYTRSQVDRCLKFAFELAEKRHT 181
Query: 650 KK 655
K+
Sbjct: 182 KE 183
>UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Isocitrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 344
Score = 42.7 bits (96), Expect = 0.008
Identities = 46/180 (25%), Positives = 71/180 (39%), Gaps = 4/180 (2%)
Frame = +2
Query: 170 RHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI-DPTMDNDDDVQY--AITTIKR 340
R+++ L G GI E V + + I+F VD+ D + + D Y A ++R
Sbjct: 8 RYSIVELHGDGIARELSQAVHTVADALPFEIEFIPVDLSDESREAKGDAIYDEAEAAMRR 67
Query: 341 NGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD-IDVVIIRQN 517
G LK T E S N LR + + PG+ T + + I + I+R
Sbjct: 68 YGTSLKYPTATTKE-----SPNRVLRERCNFAVIHRPVATIPGIQTHYNERIHLDIVRIA 122
Query: 518 TEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSD 697
T G Y S++ + S +RFAF A+ + T K I K +D
Sbjct: 123 TGGTYEDAGRRINRDTAVSIRAIERRPSVLASRFAFRLAQLRDSNVIAT-SKYTIQKATD 181
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 42.7 bits (96), Expect = 0.008
Identities = 54/197 (27%), Positives = 83/197 (42%), Gaps = 25/197 (12%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVD--IDPTMDND----DDVQYAIT 328
V ++ G GIGPE I K+ GAP+ + P + DD A+
Sbjct: 10 VAVVGGEGIGPEVTDQSHRILKWFSDRRGAPVILREAQYGLIPYLATGKVLPDDTVEAME 69
Query: 329 TIKRNGVGLKGNIETKS--EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRH------ 484
G G ET AA ++LR++ D+YA + + P +A
Sbjct: 70 EADAILWGATGGPETTEVPPAARKAGSLLSLRSKYDLYANLRPIVANPALADSAPLKAAV 129
Query: 485 -KDIDVVIIRQNTEGEYAMLEHESVNGVVESMK------VVTADNSERVARFAFEFAKKN 643
KD+D +IIR+ T G Y E + + + + T RVAR AFE A+
Sbjct: 130 LKDVDFIIIRELTSGIY-FGEPRGIETLPDGQRRGFNTQQYTTSQIRRVARTAFELARTR 188
Query: 644 GRKKVTTVHKANIMKLS 694
+ +V +V KAN+++ S
Sbjct: 189 -KGRVCSVDKANVLETS 204
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 42.3 bits (95), Expect = 0.011
Identities = 23/69 (33%), Positives = 36/69 (52%)
Frame = +2
Query: 488 DIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTV 667
+ID V++R+ T G Y E + V ER+ AF+ A K +KKVT++
Sbjct: 123 EIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLASKR-KKKVTSI 181
Query: 668 HKANIMKLS 694
KAN+++ S
Sbjct: 182 DKANVLESS 190
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 41.5 bits (93), Expect = 0.019
Identities = 33/116 (28%), Positives = 46/116 (39%), Gaps = 4/116 (3%)
Frame = +2
Query: 311 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT-RHK 487
V A ++ +G GLK T V S N LR E+D + + PGV T
Sbjct: 56 VYEAAAAMREHGYGLKAATITPEGRGDVGSPNAILRREIDGTVILRTGRPLPGVETIGGI 115
Query: 488 DIDVVIIRQNTEGEYAMLEHESVNGVVE---SMKVVTADNSERVARFAFEFAKKNG 646
+ ++R TE Y E G E ++A N A FAF A++ G
Sbjct: 116 TAPIAVVRMATEDAYEAKEWREGEGDEERAFRTTYISARNCRATAEFAFRLARQMG 171
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 41.5 bits (93), Expect = 0.019
Identities = 24/68 (35%), Positives = 39/68 (57%), Gaps = 4/68 (5%)
Frame = +2
Query: 488 DIDVVIIRQNTEGEYAMLE---HESV-NGVVESMKVVTADNSERVARFAFEFAKKNGRKK 655
D++ V IR+NTEGEY+ + H + + VV V T +ER+ R+A++ A RK+
Sbjct: 124 DVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAPRKR 183
Query: 656 VTTVHKAN 679
+ K+N
Sbjct: 184 LCGATKSN 191
>UniRef50_Q5FK36 Cluster: Putative ATPase; n=1; Lactobacillus
acidophilus|Rep: Putative ATPase - Lactobacillus
acidophilus
Length = 686
Score = 40.7 bits (91), Expect = 0.033
Identities = 30/130 (23%), Positives = 60/130 (46%), Gaps = 3/130 (2%)
Frame = +2
Query: 272 VVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYV-TSRNVALRNELDMYAYIL 448
+VD+D DN D V+Y ++K+ + + + ET + + + + A N D+Y
Sbjct: 309 IVDVDG--DNRDAVEYLTKSLKKINIKVVNSSETSLKLNIIHNTEHYAKNNLTDLY---- 362
Query: 449 NCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAF- 625
+P V T+H ++ ++I Y+ ++ + ++ + DN E +F F
Sbjct: 363 ----HPSVDTQHITVENLLIESLNATLYSAVKELIIKNDLKEKSISLIDNQEMPTQFTFF 418
Query: 626 -EFAKKNGRK 652
+F K N +K
Sbjct: 419 KQFRKDNDKK 428
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 37.9 bits (84), Expect = 0.24
Identities = 48/208 (23%), Positives = 85/208 (40%), Gaps = 36/208 (17%)
Frame = +2
Query: 179 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID-----------PTM------DNDD 307
+ +LPG GIG E +F+ + P+ DI P+ +D
Sbjct: 9 IAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAAIPSRTWQLIASSDT 68
Query: 308 DVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK 487
+ AIT+ + + + K Y S + LR LD++A + C S + + K
Sbjct: 69 VLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFS---IDDQSK 125
Query: 488 DIDVVIIRQNTEGEYAMLEHESVNGVVESM-------KVVTADNSE------------RV 610
+ IIR+N+EG Y ++ + + S+ + + AD + R+
Sbjct: 126 PFNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASCALRLQSKSGLTRL 185
Query: 611 ARFAFEFAKKNGRKKVTTVHKANIMKLS 694
FAF+ A + G +VT K N+++ S
Sbjct: 186 FDFAFKHAMQTGMPRVTLADKPNVLRES 213
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 37.1 bits (82), Expect = 0.41
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 6/74 (8%)
Frame = +2
Query: 491 IDVVIIRQNTEGEY------AMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRK 652
ID+V++R+ T G Y + + V +M A+ +R+AR AFE A+K R+
Sbjct: 136 IDLVVVRELTGGIYFGQPKGIFTDAKGSRRGVNTMAYSEAE-VDRIARVAFELARKR-RR 193
Query: 653 KVTTVHKANIMKLS 694
K+ +V KAN++++S
Sbjct: 194 KLCSVDKANVLEVS 207
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 36.3 bits (80), Expect = 0.72
Identities = 18/37 (48%), Positives = 20/37 (54%)
Frame = +2
Query: 164 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 274
GG VT++PG GIGPE V IF API V
Sbjct: 2 GGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQANV 38
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 35.5 bits (78), Expect = 1.3
Identities = 51/201 (25%), Positives = 85/201 (42%), Gaps = 27/201 (13%)
Frame = +2
Query: 173 HAVTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDPTMDNDDDVQYAITTIKR 340
+ + +L G GIGPE M R + K + G I++ D+ ++ T+K
Sbjct: 3 YQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKG 62
Query: 341 NGVG---LKGNIETKSEAAYVTSRN------VALRNELDMYAYILNCKSYPGV---ATRH 484
L G++ + + LR +++ + K + G+ +
Sbjct: 63 CEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLR 122
Query: 485 KDI-----DVVIIRQNTEGEY------AMLEHESVNGVVESMKVVTADNSERVARFAFEF 631
DI DV+ +R+ T G Y E ES ++M+ + S R+AR AFE
Sbjct: 123 SDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAF-DTMRYSRREIS-RIARIAFE- 179
Query: 632 AKKNGRKKVTTVHKANIMKLS 694
A + RKKVT+V KAN++ S
Sbjct: 180 AARGRRKKVTSVDKANVLACS 200
>UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata
D2|Rep: VCBS - Pseudoalteromonas tunicata D2
Length = 1600
Score = 35.1 bits (77), Expect = 1.7
Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Frame = +2
Query: 89 TLSDFDVQHKTPVIRKQKLI--PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPI 262
T+++ QH T ++ +L+ P+A Y G +T G G GYV K + A I
Sbjct: 1330 TVTNISAQHGTVTLQNGQLVYTPQASYSGADEITYTVSDGKGGSAQGYVEVTIKPVNATI 1389
Query: 263 DFEVVD 280
V+
Sbjct: 1390 SLIAVN 1395
>UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Dehalococcoides sp. (strain CBDB1)
Length = 365
Score = 35.1 bits (77), Expect = 1.7
Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 12/105 (11%)
Frame = +2
Query: 407 VALRNELDMYAYILNCKSYPGVATRH-------KDIDVVIIRQNTEGEYAMLEHE---SV 556
+ALR L ++A I K P + K D + IR+ T G Y + +
Sbjct: 93 LALRKGLGLFANIRPVKVAPSLVNSTPIKAEIVKGTDFIFIRELTGGVYFAKPKKRWTTP 152
Query: 557 NGVVESMKVVT-ADNS-ERVARFAFEFAKKNGRKKVTTVHKANIM 685
G+ ++ +T ++N ER+ R FE AK N +KK+ +V KAN++
Sbjct: 153 AGIRKATDSMTYSENEIERIVRVGFELAK-NRKKKLVSVDKANVL 196
>UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular
organisms|Rep: Agmatine deiminase - Roseiflexus sp. RS-1
Length = 348
Score = 34.7 bits (76), Expect = 2.2
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 1/77 (1%)
Frame = +2
Query: 113 HKTPVIRKQKLIPK-AQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDP 289
++ P + ++++ + Y G + L G +G + G++ D+ +++ VV+ DP
Sbjct: 180 NRNPHLTREQIEQRLCDYLGVSNILWLGDGIVGDDTDGHIDDLARFVAPDTVVTVVESDP 239
Query: 290 TMDNDDDVQYAITTIKR 340
T +N D +Q + +KR
Sbjct: 240 TDENYDALQENLRRLKR 256
>UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_8,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 293
Score = 34.7 bits (76), Expect = 2.2
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 8/104 (7%)
Frame = +2
Query: 293 MDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRN------ELDMYAYILNC 454
M N D Y I ++ +GL +IE S +++ N+ L+N + +L+C
Sbjct: 1 MQNCDLNSYQIGLSRKQQLGLYSDIEYSSSRYSLSTNNLNLKNLQNLKNRISQLQSVLSC 60
Query: 455 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHE--SVNGVVESMK 580
K G TR K +D N + Y++ EH+ +N +SMK
Sbjct: 61 KYRKGSLTRSK-LDDSTNLTNDKSTYSLQEHKYNFINFPQQSMK 103
>UniRef50_Q08KN2 Cluster: FIg-Hepta; n=3; Takifugu rubripes|Rep:
FIg-Hepta - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1678
Score = 34.3 bits (75), Expect = 2.9
Identities = 28/131 (21%), Positives = 54/131 (41%)
Frame = -2
Query: 618 NLATLSELSAVTTFIDSTTPFTDSCSNIAYSPSVFCLIITTSMSLCLVATPG*DLQFSM* 439
N + ++L+ T + STTPFT+S + + F ++ T+ +L + ++ +
Sbjct: 517 NSTSTTDLNTTTPPVSSTTPFTNSTPPTDLNNTTFTTVVVTNSTLTSATSLNTTIKANRT 576
Query: 438 AYMSSSFLRATLRDVT*AASLLVSMLPFSPTPFLLMVVIAYWTSSSLSIVGSMSTTSKSI 259
+S+ AT T A + + S T T+S+ + + +TTS +
Sbjct: 577 TATTSATTAATTSATTEATTSATTSATTSATTSATTSATTEETTSATTSATTSATTSATT 636
Query: 258 GAPMYLNMSRT 226
A S T
Sbjct: 637 SATTEATTSAT 647
>UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4;
Vibrionales|Rep: Phosphorelay protein - Vibrio sp.
MED222
Length = 114
Score = 34.3 bits (75), Expect = 2.9
Identities = 12/27 (44%), Positives = 21/27 (77%)
Frame = -1
Query: 274 HFEVNRSTDVFEYVANVSHALRTDTAS 194
H E+N+ +D +Y+A++SHAL++ AS
Sbjct: 39 HLELNKESDTSKYLADISHALKSSAAS 65
>UniRef50_O32147 Cluster: Probable xanthine dehydrogenase subunit A;
n=1; Bacillus subtilis|Rep: Probable xanthine
dehydrogenase subunit A - Bacillus subtilis
Length = 330
Score = 34.3 bits (75), Expect = 2.9
Identities = 21/65 (32%), Positives = 31/65 (47%)
Frame = -1
Query: 649 PAVFLGEFEGEPGHPLRVVSCHHFH*LDHTIHGFVFQHSVFTFCVLSDNNNINVLMSGRN 470
P L EF+ P H VV+ HH+ D TI F+F ++ +L N L+SG++
Sbjct: 234 PEQMLSEFQFFP-HDAAVVATHHYQ-HDQTIINFLFSQNLHYIGLLGSANRTKRLLSGKH 291
Query: 469 ARVRF 455
F
Sbjct: 292 PPSHF 296
>UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3;
Acholeplasmataceae|Rep: Dihydrolipoyl dehydrogenase -
Acholeplasma laidlawii
Length = 336
Score = 34.3 bits (75), Expect = 2.9
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Frame = +2
Query: 68 SSKAAPATLSDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKY 247
SS P + K V+ ++L+ Y ++ ++ GG IG E +F
Sbjct: 141 SSAVVPPIPGVKEAYEKGIVVTSRELLNVKNYP--KSIVIVGGGVIGVE----FATVFNS 194
Query: 248 IGAPIDF-EVVD-IDPTMDNDDDVQYAITTIKRNGVGLKGNIETK 376
G+ + E++D I PTMD+D V YA T+KR+G+ + E K
Sbjct: 195 FGSKVTIIEMMDGILPTMDDDIRVAYA-KTLKRDGIEILTKAEVK 238
>UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Gammaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 389
Score = 33.9 bits (74), Expect = 3.8
Identities = 18/58 (31%), Positives = 31/58 (53%), Gaps = 4/58 (6%)
Frame = +2
Query: 494 DVVIIRQNTEGEY----AMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKK 655
D+++IR+N+EGEY L + ++V T +ER+ R AFE A + ++
Sbjct: 135 DLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAFERAARRAEER 192
>UniRef50_A0DT58 Cluster: Chromosome undetermined scaffold_62, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_62,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 505
Score = 33.9 bits (74), Expect = 3.8
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 6/124 (4%)
Frame = +2
Query: 311 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNEL----DMYAYILNCKSYPGVAT 478
+Q IT + + LKGN K + T N+ + EL D+ +YI K Y +
Sbjct: 55 IQNEITVLSK----LKGNFILKLHDYFYTKNNIYIITELCKQGDLQSYI---KKYGKL-- 105
Query: 479 RHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAF--EFAKKNGRK 652
+ +I + II Q G +M + ++ ++ ++ +DN+ R+A F F E +K +
Sbjct: 106 -NSNIAIQIIIQIIYGIVSMQQENIIHRDLKPQNILISDNTIRIADFGFAKEMSKLSSEM 164
Query: 653 KVTT 664
V T
Sbjct: 165 NVGT 168
>UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Streptococcus suis 89/1591|Rep:
Isocitrate/isopropylmalate dehydrogenase - Streptococcus
suis 89/1591
Length = 207
Score = 33.5 bits (73), Expect = 5.1
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 7/94 (7%)
Frame = +2
Query: 413 LRNELDMYAYILNCKSY-------PGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 571
LR EL ++A I K + P A R +D+V++R+ T G Y +H
Sbjct: 93 LRKELGLFANIRPVKIFDSLKDYSPLKADRLDGVDLVMVRELTGGIY-FGKHILETYQAS 151
Query: 572 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 673
A+ ERV R AF+ A+K +K + +
Sbjct: 152 DSNTYQAEEIERVVRSAFDLAQKRQKKSPALISR 185
>UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2;
Roseovarius|Rep: SCO1/SenC family protein - Roseovarius
sp. 217
Length = 217
Score = 33.5 bits (73), Expect = 5.1
Identities = 18/56 (32%), Positives = 29/56 (51%)
Frame = +2
Query: 218 MGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEA 385
M ++ + G + ++ IDP +D + + A+T I + VGL GN E SEA
Sbjct: 90 MADAAEVLERRGISVSPVLITIDPVLDTVETMGPALTKISADLVGLTGNREALSEA 145
>UniRef50_Q8IC48 Cluster: Putative uncharacterized protein
PF07_0004; n=1; Plasmodium falciparum 3D7|Rep: Putative
uncharacterized protein PF07_0004 - Plasmodium
falciparum (isolate 3D7)
Length = 964
Score = 33.5 bits (73), Expect = 5.1
Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Frame = +2
Query: 260 IDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNE-LDMY 436
I++E+++++ D+D+DV+Y + I+ + +E K E N L+ E L+
Sbjct: 172 IEYEIIEVEVDDDDDEDVEYEVIEIEVDDDEEVELLEDKEEKIEEVKENKQLKVESLEKK 231
Query: 437 AY-ILNCKSYPGVATRHKDID 496
I YP V K+ID
Sbjct: 232 PLEIKTTPKYPFVTDEQKEID 252
>UniRef50_Q6C705 Cluster: Similar to DEHA0E18414g Debaryomyces
hansenii; n=1; Yarrowia lipolytica|Rep: Similar to
DEHA0E18414g Debaryomyces hansenii - Yarrowia lipolytica
(Candida lipolytica)
Length = 383
Score = 33.5 bits (73), Expect = 5.1
Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 4/80 (5%)
Frame = +2
Query: 401 RNVALRNELDMY---AYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 571
+ ++LR ++ Y A+I K GVAT HK+I V ++Q + Y ++ ES N ++
Sbjct: 241 QKLSLREHVESYLNEAHIYVDKK--GVATTHKEITVSSLQQIKDTPYLLVNVESTNAII- 297
Query: 572 SMKVVTADNSERVAR-FAFE 628
+K+V DN VA FA E
Sbjct: 298 VLKIV--DNKLEVASVFATE 315
>UniRef50_A3BGI7 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (japonica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. japonica
(Rice)
Length = 377
Score = 33.1 bits (72), Expect = 6.7
Identities = 16/42 (38%), Positives = 27/42 (64%), Gaps = 1/42 (2%)
Frame = +2
Query: 533 AMLEHESVNGVV-ESMKVVTADNSERVARFAFEFAKKNGRKK 655
AML+ +V V+ + ++ N+E+V RFA E K++GR+K
Sbjct: 312 AMLQQRNVEAVMFQGRRLAGETNAEKVERFARELIKEHGRRK 353
>UniRef50_UPI000065D57A Cluster: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik; n=1; Takifugu
rubripes|Rep: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik - Takifugu rubripes
Length = 605
Score = 32.7 bits (71), Expect = 8.8
Identities = 20/59 (33%), Positives = 29/59 (49%)
Frame = +3
Query: 240 SNTSVLLLTSKWWTLTQRWTMMMMSNML*RPLRGTVWG*RATLKPKVRQPM*RHAMWLS 416
S+ V +LTS W +T+ M+MSN L R W R LK R P+ +W++
Sbjct: 115 SSYGVAILTSAWLKVTEEKKKMLMSNFLKR----LTWPFRECLKTLKRLPLCTWIIWMN 169
>UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces
pombe|Rep: Cullin-4 - Schizosaccharomyces pombe (Fission
yeast)
Length = 734
Score = 32.7 bits (71), Expect = 8.8
Identities = 16/51 (31%), Positives = 27/51 (52%)
Frame = +2
Query: 293 MDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYI 445
M +DD VQY I +K G+ L +++T E + + R + D+Y Y+
Sbjct: 685 MKHDDLVQYVINNVKDRGIPLVSDVKTAIEK--LLEKEYLEREDNDIYTYV 733
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 740,245,709
Number of Sequences: 1657284
Number of extensions: 16079810
Number of successful extensions: 49990
Number of sequences better than 10.0: 115
Number of HSP's better than 10.0 without gapping: 47694
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 49869
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 54958682807
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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