Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte5m14
(691 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B6095 Cluster: PREDICTED: similar to tryptophan... 267 2e-70
UniRef50_P20351 Cluster: Tryptophan 2,3-dioxygenase; n=47; Eumet... 255 6e-67
UniRef50_Q1EG62 Cluster: Tryptophan oxygenase; n=1; Heliconius m... 241 9e-63
UniRef50_Q8I7L6 Cluster: Putative uncharacterized protein; n=1; ... 196 6e-49
UniRef50_Q09474 Cluster: Putative tryptophan 2,3-dioxygenase; n=... 196 6e-49
UniRef50_P48775 Cluster: Tryptophan 2,3-dioxygenase; n=38; Coelo... 194 1e-48
UniRef50_Q55DB4 Cluster: Tryptophan 2,3-dioxygenase; n=1; Dictyo... 168 1e-40
UniRef50_Q6MM37 Cluster: Tryptophan 2,3-dioxygenase; n=1; Bdello... 155 1e-36
UniRef50_A4B6L1 Cluster: Tryptophan 2,3-dioxygenase; n=1; Altero... 151 2e-35
UniRef50_UPI0000E478ED Cluster: PREDICTED: similar to tryptophan... 130 3e-29
UniRef50_Q1VLY0 Cluster: Putative tryptophan-2,3-dioxygenase oxi... 124 2e-27
UniRef50_A1SG03 Cluster: Tryptophan 2,3-dioxygenase; n=1; Nocard... 114 2e-24
UniRef50_Q1ITW3 Cluster: Tryptophan 2,3-dioxygenase; n=9; Bacter... 112 9e-24
UniRef50_Q2IEC3 Cluster: Tryptophan 2,3-dioxygenase; n=3; Bacter... 111 1e-23
UniRef50_Q81PQ0 Cluster: Tryptophan 2,3-dioxygenase family prote... 103 4e-21
UniRef50_Q6W756 Cluster: Tryptophan 2,3-dioxygenase; n=1; Gemmat... 101 1e-20
UniRef50_Q0SFS2 Cluster: Tryptophan 2,3-dioxygenase; n=7; Bacter... 99 9e-20
UniRef50_A3RQV6 Cluster: Tryptophan 2,3-dioxygenase; n=2; Ralsto... 99 1e-19
UniRef50_A0JUV5 Cluster: Tryptophan 2,3-dioxygenase; n=17; Bacte... 97 3e-19
UniRef50_Q126P7 Cluster: Tryptophan 2,3-dioxygenase; n=14; Bacte... 96 8e-19
UniRef50_Q62M99 Cluster: Tryptophan 2,3-dioxygenase family prote... 89 9e-17
UniRef50_Q333W0 Cluster: Tryptophan 2,3-dioxygenase; n=2; Actino... 86 9e-16
UniRef50_Q1GTB7 Cluster: Tryptophan 2,3-dioxygenase; n=2; Proteo... 85 2e-15
UniRef50_Q5PT47 Cluster: TrsC; n=1; Streptomyces triostinicus|Re... 80 4e-14
UniRef50_Q15YU8 Cluster: Tryptophan 2 3-dioxygenase (Vermilion)-... 66 1e-09
UniRef50_A1ZKV2 Cluster: Tryptophan 2,3-dioxygenase; n=2; Sphing... 64 2e-09
UniRef50_A3U5U4 Cluster: Tryptophan 2,3-dioxygenase family prote... 64 3e-09
UniRef50_Q50EC4 Cluster: Putative oxidoreductase; n=1; Streptomy... 64 4e-09
UniRef50_Q4VPT1 Cluster: Tryptophan 2,3-dioxygenase; n=2; Myxoco... 62 2e-08
UniRef50_Q11V86 Cluster: Tryptophan 2,3-dioxygenase; n=1; Cytoph... 62 2e-08
UniRef50_A3XQC2 Cluster: Tryptophan 2,3-dioxygenase; n=9; Bacter... 62 2e-08
UniRef50_A0M172 Cluster: Tryptophan 2,3-dioxygenase; n=3; Flavob... 61 3e-08
UniRef50_Q47RF8 Cluster: Putative tryptophan 2,3-dioxygenase; n=... 55 1e-06
UniRef50_Q7NIX4 Cluster: Glr2058 protein; n=2; Cyanobacteria|Rep... 55 2e-06
UniRef50_Q82ET7 Cluster: Putative tryptophan 2,3-dioxygenase; n=... 54 2e-06
UniRef50_A1G3A0 Cluster: Putative uncharacterized protein; n=1; ... 53 6e-06
UniRef50_A1GDT5 Cluster: Tryptophan 2,3-dioxygenase; n=2; Salini... 52 1e-05
UniRef50_A1G3A1 Cluster: Putative uncharacterized protein; n=1; ... 51 2e-05
UniRef50_Q7N6V3 Cluster: Similarities with putative oxidoreducta... 51 3e-05
UniRef50_Q0LUG5 Cluster: Tryptophan 2,3-dioxygenase; n=1; Caulob... 50 7e-05
UniRef50_Q4US93 Cluster: Tryptophan 2,3-dioxygenase; n=3; Proteo... 44 0.003
UniRef50_Q82Y87 Cluster: Putative dioxygenase; n=1; Streptomyces... 40 0.076
UniRef50_Q03WD2 Cluster: Phosphoglycerol transferase related pro... 37 0.40
UniRef50_Q4Q0S9 Cluster: Putative uncharacterized protein; n=3; ... 35 1.6
UniRef50_Q389X9 Cluster: Putative uncharacterized protein; n=1; ... 35 1.6
UniRef50_A1Z9H0 Cluster: CG6280-PA; n=2; Sophophora|Rep: CG6280-... 35 2.2
UniRef50_Q54X30 Cluster: Putative uncharacterized protein; n=1; ... 33 5.0
UniRef50_Q2IZV6 Cluster: Generic methyltransferase; n=1; Rhodops... 33 6.6
UniRef50_Q08VX1 Cluster: Tryptophan 2,3-dioxygenase; n=1; Stigma... 33 6.6
UniRef50_A3VH76 Cluster: Putative uncharacterized protein; n=1; ... 33 6.6
>UniRef50_UPI00015B6095 Cluster: PREDICTED: similar to tryptophan
oxygenase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to tryptophan oxygenase - Nasonia vitripennis
Length = 423
Score = 267 bits (655), Expect = 2e-70
Identities = 132/191 (69%), Positives = 158/191 (82%)
Frame = +1
Query: 118 MACPMRSAIDEINGQEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFII 297
MACP+ + D+ + Q G L G+LYGEYL LDK+LSAQR+LS+E K VHDEHLFI+
Sbjct: 1 MACPVGNGTDDAS-QVGTCLTEGPGLLYGEYLRLDKILSAQRLLSSECDKEVHDEHLFIV 59
Query: 298 THQAYELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETM 477
THQAYELWFKQII+E+DSVRA E +DES T+EILKRLNRIVLILKLLVDQV ILETM
Sbjct: 60 THQAYELWFKQIIYELDSVRAFS--EAIDESRTLEILKRLNRIVLILKLLVDQVSILETM 117
Query: 478 TPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQK 657
TPLDFM FR YL PASGFQSLQFRLLENKLG+KQ RVKY+Q+Y VFG DP+A++++++
Sbjct: 118 TPLDFMAFRDYLCPASGFQSLQFRLLENKLGVKQEHRVKYSQSYTRVFGRDPQAIEAIKR 177
Query: 658 SEQEPALLALI 690
SE+EP+L L+
Sbjct: 178 SEEEPSLSHLV 188
>UniRef50_P20351 Cluster: Tryptophan 2,3-dioxygenase; n=47;
Eumetazoa|Rep: Tryptophan 2,3-dioxygenase - Drosophila
melanogaster (Fruit fly)
Length = 379
Score = 255 bits (625), Expect = 6e-67
Identities = 125/191 (65%), Positives = 150/191 (78%)
Frame = +1
Query: 118 MACPMRSAIDEINGQEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFII 297
M+CP ++ + L E G +YGEYLMLDKLL AQ MLS E +PVHDEHLFII
Sbjct: 1 MSCPYAGNGND-HDDSAVPLTTEVGKIYGEYLMLDKLLDAQCMLSEEDKRPVHDEHLFII 59
Query: 298 THQAYELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETM 477
THQAYELWFKQIIFE DS+R +L+ E +DE+ T+EI+KRLNR+VLILKLLVDQV ILETM
Sbjct: 60 THQAYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETM 119
Query: 478 TPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQK 657
TPLDFMDFR YL PASGFQSLQFRL+ENKLG+ RV+YNQ Y VF D+ EA +S++
Sbjct: 120 TPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQKYSDVFSDE-EARNSIRN 178
Query: 658 SEQEPALLALI 690
SE++P+LL L+
Sbjct: 179 SEKDPSLLELV 189
>UniRef50_Q1EG62 Cluster: Tryptophan oxygenase; n=1; Heliconius
melpomene rosina|Rep: Tryptophan oxygenase - Heliconius
melpomene rosina
Length = 195
Score = 241 bits (591), Expect = 9e-63
Identities = 117/126 (92%), Positives = 124/126 (98%)
Frame = +1
Query: 313 ELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDF 492
ELWFKQIIFEVDSVR+LL+VEGLDESHTMEILKRLNR+VLILKLLVDQVMILETMTPLD
Sbjct: 1 ELWFKQIIFEVDSVRSLLDVEGLDESHTMEILKRLNRVVLILKLLVDQVMILETMTPLDL 60
Query: 493 MDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEP 672
MDFR YLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAM++L+KSE+EP
Sbjct: 61 MDFRTYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMEALKKSEEEP 120
Query: 673 ALLALI 690
ALLALI
Sbjct: 121 ALLALI 126
>UniRef50_Q8I7L6 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 245
Score = 196 bits (477), Expect = 6e-49
Identities = 95/168 (56%), Positives = 128/168 (76%), Gaps = 1/168 (0%)
Frame = +1
Query: 190 GMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLN 369
G Y EYL LDK+L+AQR+ S + V DEHLFI+ HQA+ELWFKQIIF++D+VR LLN
Sbjct: 36 GQTYSEYLQLDKILTAQRLKSEADGQRVDDEHLFIVIHQAHELWFKQIIFDLDNVRKLLN 95
Query: 370 VEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFR 549
+DE+ T++I+ L+R+ IL LL +Q+ +L+TM+PLDF+DFR YL PASGFQSLQFR
Sbjct: 96 NTIVDETKTLKIVSGLDRMTKILSLLTEQITLLDTMSPLDFVDFRKYLTPASGFQSLQFR 155
Query: 550 LLENKLGLKQALRVKYN-QNYQTVFGDDPEAMDSLQKSEQEPALLALI 690
+LENKLG++Q R+KYN Q+Y+ VF D + +L +E+E +LL LI
Sbjct: 156 VLENKLGVRQERRIKYNAQHYKNVFNDTD--LKTLNVTEEEKSLLTLI 201
>UniRef50_Q09474 Cluster: Putative tryptophan 2,3-dioxygenase; n=3;
Caenorhabditis|Rep: Putative tryptophan 2,3-dioxygenase
- Caenorhabditis elegans
Length = 403
Score = 196 bits (477), Expect = 6e-49
Identities = 95/168 (56%), Positives = 128/168 (76%), Gaps = 1/168 (0%)
Frame = +1
Query: 190 GMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLN 369
G Y EYL LDK+L+AQR+ S + V DEHLFI+ HQA+ELWFKQIIF++D+VR LLN
Sbjct: 36 GQTYSEYLQLDKILTAQRLKSEADGQRVDDEHLFIVIHQAHELWFKQIIFDLDNVRKLLN 95
Query: 370 VEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFR 549
+DE+ T++I+ L+R+ IL LL +Q+ +L+TM+PLDF+DFR YL PASGFQSLQFR
Sbjct: 96 NTIVDETKTLKIVSGLDRMTKILSLLTEQITLLDTMSPLDFVDFRKYLTPASGFQSLQFR 155
Query: 550 LLENKLGLKQALRVKYN-QNYQTVFGDDPEAMDSLQKSEQEPALLALI 690
+LENKLG++Q R+KYN Q+Y+ VF D + +L +E+E +LL LI
Sbjct: 156 VLENKLGVRQERRIKYNAQHYKNVFNDTD--LKTLNVTEEEKSLLTLI 201
>UniRef50_P48775 Cluster: Tryptophan 2,3-dioxygenase; n=38;
Coelomata|Rep: Tryptophan 2,3-dioxygenase - Homo sapiens
(Human)
Length = 406
Score = 194 bits (474), Expect = 1e-48
Identities = 99/184 (53%), Positives = 131/184 (71%), Gaps = 2/184 (1%)
Frame = +1
Query: 145 DEINGQEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWF 324
+E Q G + ++ G++YG YL L+K+L+AQ + S +HDEHLFIITHQAYELWF
Sbjct: 24 EEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWF 83
Query: 325 KQIIFEVDSVRALL-NVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDF 501
KQI++E+DSVR + N DE + ++++ R++R+ +ILKLLV Q ILETMT LDF DF
Sbjct: 84 KQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDF 143
Query: 502 RHYLRPASGFQSLQFRLLENKLGLKQALRVKYN-QNYQTVFGDDPEAMDSLQKSEQEPAL 678
R YL PASGFQSLQFRLLENK+G+ Q +RV YN ++Y+ F E + L KSEQE L
Sbjct: 144 REYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNF--KGEENELLLKSEQEKTL 201
Query: 679 LALI 690
L L+
Sbjct: 202 LELV 205
>UniRef50_Q55DB4 Cluster: Tryptophan 2,3-dioxygenase; n=1;
Dictyostelium discoideum AX4|Rep: Tryptophan
2,3-dioxygenase - Dictyostelium discoideum AX4
Length = 400
Score = 168 bits (408), Expect = 1e-40
Identities = 90/193 (46%), Positives = 125/193 (64%)
Frame = +1
Query: 112 IEMACPMRSAIDEINGQEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLF 291
IE A M +ID + Q+G + YG YL LD+LL+ Q S + P H+E LF
Sbjct: 24 IEKATLMEPSIDAQSAQKGVY--------YGSYLKLDELLNIQECESVKVGAPAHEEMLF 75
Query: 292 IITHQAYELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILE 471
II HQ YELWFKQ+I E+DS+R++++ E I+ RL RI I KLLVDQ+ ILE
Sbjct: 76 IIIHQTYELWFKQMIHEIDSIRSIMSTPPTPERLNGVIVNRLGRITEIQKLLVDQISILE 135
Query: 472 TMTPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSL 651
TMT +DF++FR+ L PASGFQS+QFR++ENKLG+ RV+Y Q++ F ++ + +L
Sbjct: 136 TMTSVDFLEFRNLLVPASGFQSVQFRMIENKLGILPNTRVQYQQHHYHSFFNEKD-RKAL 194
Query: 652 QKSEQEPALLALI 690
Q +E E +LL L+
Sbjct: 195 QATENEVSLLQLV 207
>UniRef50_Q6MM37 Cluster: Tryptophan 2,3-dioxygenase; n=1;
Bdellovibrio bacteriovorus|Rep: Tryptophan
2,3-dioxygenase - Bdellovibrio bacteriovorus
Length = 359
Score = 155 bits (375), Expect = 1e-36
Identities = 79/136 (58%), Positives = 95/136 (69%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
Y +YL L+ LL+AQ S E KP HDE LFII HQ YELWFKQI+FE+DSV +
Sbjct: 8 YHDYLGLNPLLNAQHPKSTEYGKPAHDELLFIIVHQTYELWFKQILFELDSVLSTFQKPT 67
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
+ ES RL RIV ILKL++ QV +LETMTPLDF+DFR L PASGFQS Q+RL+E
Sbjct: 68 VAESEMGIASARLERIVSILKLIIGQVDVLETMTPLDFLDFRDMLYPASGFQSYQWRLIE 127
Query: 559 NKLGLKQALRVKYNQN 606
KLGL+ R+ YNQ+
Sbjct: 128 TKLGLRIGDRLAYNQS 143
>UniRef50_A4B6L1 Cluster: Tryptophan 2,3-dioxygenase; n=1;
Alteromonas macleodii 'Deep ecotype'|Rep: Tryptophan
2,3-dioxygenase - Alteromonas macleodii 'Deep ecotype'
Length = 362
Score = 151 bits (365), Expect = 2e-35
Identities = 74/165 (44%), Positives = 107/165 (64%), Gaps = 1/165 (0%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
YG+YL LDK+L AQ + S + H+E LFII HQ YELWFKQ++ E+++V N E
Sbjct: 10 YGDYLQLDKILGAQDLQSEKYGDGAHEEMLFIIVHQVYELWFKQVLHELNAVIDTFNQEA 69
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
+ + +++ RL RI+ I KL+ DQ+ I+ETMTP F+ FR YL PASGFQS+QF+ LE
Sbjct: 70 VKDQQLTQVVHRLQRIIQIQKLMNDQIAIMETMTPQQFLSFRDYLVPASGFQSIQFKRLE 129
Query: 559 NKLGLKQALRVKYN-QNYQTVFGDDPEAMDSLQKSEQEPALLALI 690
LGLK+ R+ ++ Q++ D A+ L+ E +P+L L+
Sbjct: 130 ISLGLKREFRIDFDKQSFYNRLTDKDRAL--LENLENKPSLFELV 172
>UniRef50_UPI0000E478ED Cluster: PREDICTED: similar to tryptophan
2,3-dioxygenase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to tryptophan 2,3-dioxygenase -
Strongylocentrotus purpuratus
Length = 413
Score = 130 bits (314), Expect = 3e-29
Identities = 65/129 (50%), Positives = 88/129 (68%), Gaps = 1/129 (0%)
Frame = +1
Query: 307 AYELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPL 486
AYELWFKQ I EVDS+R +LN DE + + R++RI+LILKL++DQ+ ILETM+PL
Sbjct: 100 AYELWFKQTIHEVDSIREILNERPFDEKKMLMVNNRMDRIILILKLMLDQLTILETMSPL 159
Query: 487 DFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKY-NQNYQTVFGDDPEAMDSLQKSE 663
F +FR YL PASGFQS QFR+ ENK+G+K R++Y Q+Y +P +QK+
Sbjct: 160 SFFNFRDYLAPASGFQSAQFRVFENKMGIKPDNRIQYMKQDYAAQC--NPIKHGDIQKAV 217
Query: 664 QEPALLALI 690
+E L L+
Sbjct: 218 EEDTLFQLV 226
>UniRef50_Q1VLY0 Cluster: Putative tryptophan-2,3-dioxygenase
oxidoreductase protein; n=1; Psychroflexus torquis ATCC
700755|Rep: Putative tryptophan-2,3-dioxygenase
oxidoreductase protein - Psychroflexus torquis ATCC
700755
Length = 351
Score = 124 bits (300), Expect = 2e-27
Identities = 62/133 (46%), Positives = 85/133 (63%)
Frame = +1
Query: 193 MLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNV 372
M Y YL LD+LL Q S P +DE FIITHQA+ELWFKQ+ E+D+V L+
Sbjct: 11 MTYSGYLRLDELLQLQAGPEGHSPSPSNDEMHFIITHQAFELWFKQVRAELDAVHDYLSQ 70
Query: 373 EGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRL 552
E +DE H +I+ L R++ I +LL +Q ++ET++P F+ FR L +SGF+S Q R
Sbjct: 71 ESVDEKHLPQIVHHLERVIEIFRLLANQWKVMETLSPQGFLAFRDRLGTSSGFESWQMRA 130
Query: 553 LENKLGLKQALRV 591
+E +LGLKQ RV
Sbjct: 131 MEMRLGLKQESRV 143
>UniRef50_A1SG03 Cluster: Tryptophan 2,3-dioxygenase; n=1;
Nocardioides sp. JS614|Rep: Tryptophan 2,3-dioxygenase -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 267
Score = 114 bits (275), Expect = 2e-24
Identities = 65/131 (49%), Positives = 83/131 (63%), Gaps = 1/131 (0%)
Frame = +1
Query: 187 AGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVR-AL 363
A + YG YL L +LL AQ + ES P HDE LFI HQ YELWFKQ++ EV + R A+
Sbjct: 13 AQLTYGSYLRLPQLLEAQHL---ESDPPAHDELLFITIHQVYELWFKQLLHEVSAARDAM 69
Query: 364 LNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQ 543
L E + L L R+ +I ++LV Q+ +LETMTP +F++FR L PASGFQS+Q
Sbjct: 70 LGGEAGGRLWWAQHL--LTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPASGFQSVQ 127
Query: 544 FRLLENKLGLK 576
FR LE G K
Sbjct: 128 FRELEFLSGAK 138
>UniRef50_Q1ITW3 Cluster: Tryptophan 2,3-dioxygenase; n=9;
Bacteria|Rep: Tryptophan 2,3-dioxygenase - Acidobacteria
bacterium (strain Ellin345)
Length = 629
Score = 112 bits (269), Expect = 9e-24
Identities = 67/174 (38%), Positives = 94/174 (54%), Gaps = 3/174 (1%)
Frame = +1
Query: 166 GAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEV 345
G G+E + YG YL + +LLS Q++ +S P HDE LFI+ HQ YELWFK+++ ++
Sbjct: 352 GNGAGDEHKLTYGSYLKIPELLSLQQL---QSEPPRHDELLFIVIHQTYELWFKELLHDL 408
Query: 346 DSVRALLNVEGLD---ESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLR 516
++V L D E + L R +L++LV Q ILETM P F+ FR L
Sbjct: 409 EAVVRCLQAVARDPRARDEVYEAARLLRRCTEVLRVLVSQFTILETMLPTHFLAFRDKLE 468
Query: 517 PASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPAL 678
PASGFQS QFR +E GL+ ++ V +P+ L K EP+L
Sbjct: 469 PASGFQSQQFRQIEFLCGLR-------DEKLMRVHEPEPKEHAELVKRLHEPSL 515
>UniRef50_Q2IEC3 Cluster: Tryptophan 2,3-dioxygenase; n=3;
Bacteria|Rep: Tryptophan 2,3-dioxygenase -
Anaeromyxobacter dehalogenans (strain 2CP-C)
Length = 265
Score = 111 bits (268), Expect = 1e-23
Identities = 64/130 (49%), Positives = 83/130 (63%)
Frame = +1
Query: 181 NEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRA 360
+ A + YG YL LD+LL+AQR S E HDE LFI+ HQ YELWFKQ++ E+ ++
Sbjct: 7 HSAALTYGSYLALDELLAAQRPRSEE-----HDELLFIVVHQVYELWFKQVVHELTWLQE 61
Query: 361 LLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSL 540
L+ G + H + LKR ++ ILK +V QV ++ETMTP F FR L ASGFQS
Sbjct: 62 RLH-RG-EGGHALATLKR---VLTILKTVVAQVDVIETMTPRQFTAFRSRLEAASGFQSA 116
Query: 541 QFRLLENKLG 570
QFR+LE LG
Sbjct: 117 QFRVLEAMLG 126
>UniRef50_Q81PQ0 Cluster: Tryptophan 2,3-dioxygenase family protein;
n=16; Bacteria|Rep: Tryptophan 2,3-dioxygenase family
protein - Bacillus anthracis
Length = 279
Score = 103 bits (247), Expect = 4e-21
Identities = 63/173 (36%), Positives = 92/173 (53%)
Frame = +1
Query: 160 QEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIF 339
++G H + M YGEYL LD LLS+Q+ LS HDE LFI+ HQA ELW K I+
Sbjct: 10 EKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDH-----HDEMLFIVIHQASELWMKLILH 64
Query: 340 EVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRP 519
E+++ +E + + K L R+ I ++ IL T+TP ++++FR L
Sbjct: 65 ELNAA-----IESIKQDKLQPAFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQ 119
Query: 520 ASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPAL 678
ASGFQS Q+R++E LG K +K ++ DPE L + P+L
Sbjct: 120 ASGFQSYQYRMIEYALGYKTPHALK-------IYEKDPELHARLHTALHAPSL 165
>UniRef50_Q6W756 Cluster: Tryptophan 2,3-dioxygenase; n=1; Gemmata
sp. Wa1-1|Rep: Tryptophan 2,3-dioxygenase - Gemmata sp.
Wa1-1
Length = 303
Score = 101 bits (243), Expect = 1e-20
Identities = 55/137 (40%), Positives = 81/137 (59%)
Frame = +1
Query: 193 MLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNV 372
+ Y +YL ++ LL+ Q+ S HDE LFI+ HQAYELWFK ++ E+D V+
Sbjct: 46 LTYADYLHVEDLLALQK---PRSDPAEHDELLFIVVHQAYELWFKLLLHELDKVKV---- 98
Query: 373 EGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRL 552
+ T + R+ ++K+ V+QV I+ET+TP+ F FR L ASGFQS QFR
Sbjct: 99 -DFIANRTYPAISTFKRVRTVMKVAVEQVDIVETLTPMSFNSFRDRLDKASGFQSSQFRE 157
Query: 553 LENKLGLKQALRVKYNQ 603
+E LG K+A +K+ +
Sbjct: 158 MEFLLGYKRAEMLKHQK 174
>UniRef50_Q0SFS2 Cluster: Tryptophan 2,3-dioxygenase; n=7;
Bacteria|Rep: Tryptophan 2,3-dioxygenase - Rhodococcus
sp. (strain RHA1)
Length = 284
Score = 99.1 bits (236), Expect = 9e-20
Identities = 66/162 (40%), Positives = 85/162 (52%)
Frame = +1
Query: 193 MLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNV 372
M Y YL LD LLSAQ+ +S HDE LFII HQ ELW K ++ E + RA
Sbjct: 22 MSYASYLDLDTLLSAQKPVSRPEH---HDELLFIIQHQTTELWLKLVLHETLAARA---- 74
Query: 373 EGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRL 552
DE LK + R+ I K L +Q +L T+TP ++ +FR +L +SGFQS Q+R
Sbjct: 75 -AFDEDDIGRALKCVARVKHIQKTLTEQWSVLATLTPTEYSEFRRFLGNSSGFQSYQYRA 133
Query: 553 LENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPAL 678
+E LG K N VF DP A D L + EP+L
Sbjct: 134 VEFVLGNK-------NAGMLAVFEADPAAHDLLGRLLAEPSL 168
>UniRef50_A3RQV6 Cluster: Tryptophan 2,3-dioxygenase; n=2; Ralstonia
solanacearum|Rep: Tryptophan 2,3-dioxygenase - Ralstonia
solanacearum UW551
Length = 366
Score = 98.7 bits (235), Expect = 1e-19
Identities = 52/133 (39%), Positives = 76/133 (57%)
Frame = +1
Query: 193 MLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNV 372
M Y +Y+ ++ LLS Q + ++ +DE LFII HQ YELWFK I+ E+ S R LL
Sbjct: 1 MNYWDYIKVEALLSLQSGSDEDETQVGNDETLFIIVHQIYELWFKLILRELTSARDLLRQ 60
Query: 373 EGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRL 552
+ + ++ L R + + + ++ETMT DF++FR L PASGFQS Q R
Sbjct: 61 DPVPGHQITAGVRSLRRAIAVFEQANQHFRVMETMTTRDFLEFRERLTPASGFQSAQMRE 120
Query: 553 LENKLGLKQALRV 591
+E LGL+ R+
Sbjct: 121 IEILLGLEDEERI 133
>UniRef50_A0JUV5 Cluster: Tryptophan 2,3-dioxygenase; n=17;
Bacteria|Rep: Tryptophan 2,3-dioxygenase - Arthrobacter
sp. (strain FB24)
Length = 284
Score = 97.5 bits (232), Expect = 3e-19
Identities = 63/162 (38%), Positives = 85/162 (52%)
Frame = +1
Query: 193 MLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNV 372
M Y YL L LLSAQ+ +S HDE LFII HQ ELW K ++ E+ S A L
Sbjct: 22 MSYASYLQLPTLLSAQQPVSNPEH---HDEMLFIIQHQTTELWLKLVLHELRSAAAWLRS 78
Query: 373 EGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRL 552
+ L + LK + R+ I K L +Q +L T+TP ++ FR +L +SGFQS Q+R
Sbjct: 79 DDLGSA-----LKAIARVKHIQKTLTEQWSVLATLTPTEYSQFRRFLGNSSGFQSSQYRA 133
Query: 553 LENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPAL 678
+E LG K N+ VF DPEA L + P++
Sbjct: 134 VEFVLGNK-------NRKMLPVFESDPEAYQQLSNVLEAPSI 168
>UniRef50_Q126P7 Cluster: Tryptophan 2,3-dioxygenase; n=14;
Bacteria|Rep: Tryptophan 2,3-dioxygenase - Polaromonas
sp. (strain JS666 / ATCC BAA-500)
Length = 294
Score = 95.9 bits (228), Expect = 8e-19
Identities = 64/180 (35%), Positives = 96/180 (53%)
Frame = +1
Query: 145 DEINGQEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWF 324
+ I E A L M YG+YL LD +L+AQ+ LS P HDE LFII HQ ELW
Sbjct: 20 ERIVHDEKAQLDFSRDMSYGDYLQLDAILNAQKPLS-----PAHDEMLFIIQHQTSELWM 74
Query: 325 KQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFR 504
K ++ E+ + A+ NV + ++L R++RI ++ LV +L TMTP ++ R
Sbjct: 75 KLMLHELRA--AIANVAADELGSAFKMLARVSRI---MEQLVHAWDVLATMTPPEYSAMR 129
Query: 505 HYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPALLA 684
YL +SGFQS Q+R +E LG K A ++ + + + A ++ ++ LLA
Sbjct: 130 PYLGASSGFQSYQYRCIEFALGNKNAAMLQPHAHRSDLLAQVQAAYEAPSLYDEALRLLA 189
>UniRef50_Q62M99 Cluster: Tryptophan 2,3-dioxygenase family protein;
n=60; Proteobacteria|Rep: Tryptophan 2,3-dioxygenase
family protein - Burkholderia mallei (Pseudomonas
mallei)
Length = 315
Score = 89.0 bits (211), Expect = 9e-17
Identities = 59/150 (39%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Frame = +1
Query: 136 SAIDEIN-GQEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAY 312
+A D++ G A L M YG+YL LD +L AQ S P H+E LFII HQ
Sbjct: 37 AAGDDVQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRS-----PDHNEMLFIIQHQTS 91
Query: 313 ELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDF 492
ELW K ++E+ + A + + L + K L R+ +L+ LV +L TMTP ++
Sbjct: 92 ELWMKLALYELRAALASIRDDALPPA-----FKMLARVSRVLEQLVQAWNVLATMTPSEY 146
Query: 493 MDFRHYLRPASGFQSLQFRLLENKLGLKQA 582
R YL +SGFQS Q+R LE LG K A
Sbjct: 147 SAMRPYLGASSGFQSYQYRELEFILGNKNA 176
>UniRef50_Q333W0 Cluster: Tryptophan 2,3-dioxygenase; n=2;
Actinomycetales|Rep: Tryptophan 2,3-dioxygenase -
Micromonospora sp. ML1
Length = 242
Score = 85.8 bits (203), Expect = 9e-16
Identities = 51/128 (39%), Positives = 71/128 (55%), Gaps = 2/128 (1%)
Frame = +1
Query: 193 MLYGEYLMLDKLLSAQ--RMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALL 366
+ Y +YL +D LLS Q R S V EH FI+THQA ELW KQ+ +++D+ +
Sbjct: 4 LTYADYLQVDTLLSLQETRAPDTASRSVVLAEHFFIVTHQACELWLKQVTYDLDAAADAM 63
Query: 367 NVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQF 546
E + L+ L R +L++L +QV+ LE + F +FR +L ASG QS QF
Sbjct: 64 TPPYGPEDEELA-LEFLQRTAELLRVLHEQVVALERLPLRHFAEFRPFLDGASGAQSAQF 122
Query: 547 RLLENKLG 570
RLL LG
Sbjct: 123 RLLARLLG 130
>UniRef50_Q1GTB7 Cluster: Tryptophan 2,3-dioxygenase; n=2;
Proteobacteria|Rep: Tryptophan 2,3-dioxygenase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 301
Score = 85.0 bits (201), Expect = 2e-15
Identities = 62/172 (36%), Positives = 90/172 (52%)
Frame = +1
Query: 163 EGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFE 342
+G + + G+ Y ++ +LLSAQ +S KP DE LFII HQ ELW K ++ E
Sbjct: 18 DGETIQWDNGLTYARHIQTAQLLSAQVPVS---DKP--DEMLFIIMHQTMELWLKLVLHE 72
Query: 343 VDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPA 522
V + + L+ + K L+RI I + ++ +L T+TP DF+ FR +LR A
Sbjct: 73 ARLVHDAIKDDRLEIAG-----KGLDRIATIQRHMIHSWEVLATLTPHDFLTFRGFLRRA 127
Query: 523 SGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPAL 678
SGFQS Q+R LE LG K+ + V DD EA L+ + P+L
Sbjct: 128 SGFQSQQYRELEYLLGNKRG-------DMMIVHKDDAEATARLRAVFEAPSL 172
>UniRef50_Q5PT47 Cluster: TrsC; n=1; Streptomyces triostinicus|Rep:
TrsC - Streptomyces triostinicus
Length = 247
Score = 80.2 bits (189), Expect = 4e-14
Identities = 47/133 (35%), Positives = 76/133 (57%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
Y +YL+L+ LL Q+ ++ + HDE LF++ HQ++ELWFK+++ E+D+++ L
Sbjct: 11 YRDYLVLETLLDIQKPITEQ-----HDELLFVVVHQSHELWFKELLHELDALQVTLR--- 62
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
++ + L+ L R I + L Q+ +LETMT F FR L SGF S QFR +E
Sbjct: 63 --KADSGPALRTLRRARAIFRALTAQIDVLETMTADQFDAFRDQL-VGSGFYSAQFREIE 119
Query: 559 NKLGLKQALRVKY 597
LG + ++
Sbjct: 120 VVLGRRDGTAAEH 132
>UniRef50_Q15YU8 Cluster: Tryptophan 2 3-dioxygenase
(Vermilion)-like; n=1; Pseudoalteromonas atlantica
T6c|Rep: Tryptophan 2 3-dioxygenase (Vermilion)-like -
Pseudoalteromonas atlantica (strain T6c / BAA-1087)
Length = 272
Score = 65.7 bits (153), Expect = 1e-09
Identities = 49/162 (30%), Positives = 80/162 (49%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
YG YL +LLSAQ+ L+ + DE F I HQ ELW K I+ + V +E
Sbjct: 27 YGTYLHCQQLLSAQKPLTELCNG---DELQFQIVHQVEELWMKLAIYTLVDV-----LEF 78
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
+ + +T+ ++ + R+ I +++ Q+ +LETM+P ++ R L SG +S FR L
Sbjct: 79 MQQENTLRVVTLMKRVSFIQRMMSQQLDLLETMSPKEYQQIRLQLGNGSGQESPGFRTL- 137
Query: 559 NKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPALLA 684
L + L +N+ Y + E + Q S E ++A
Sbjct: 138 --LKMPTDLWSVFNEQYLVGRNKNIEQVYDSQYSHDESYVVA 177
>UniRef50_A1ZKV2 Cluster: Tryptophan 2,3-dioxygenase; n=2;
Sphingobacteriales|Rep: Tryptophan 2,3-dioxygenase -
Microscilla marina ATCC 23134
Length = 325
Score = 64.5 bits (150), Expect = 2e-09
Identities = 44/127 (34%), Positives = 65/127 (51%), Gaps = 1/127 (0%)
Frame = +1
Query: 181 NEAGMLYGEYLMLDKLLSAQRMLSAESSKP-VHDEHLFIITHQAYELWFKQIIFEVDSVR 357
N G+L+ YL + +LS ++ + DE +FI+ HQ EL+FK I+ E++ +
Sbjct: 35 NLEGLLHANYLKYWNYVHLDTLLSLQNPRTDFPDEMIFIVYHQVTELYFKLILSEIEQIA 94
Query: 358 ALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQS 537
N+ + T + LKR+N IL D ++E M F FR L PASGFQS
Sbjct: 95 TEENITA--DFFTTK-LKRINLFFQILTFSYD--TMIEGMDVKQFRQFRMALLPASGFQS 149
Query: 538 LQFRLLE 558
Q R +E
Sbjct: 150 AQIRKIE 156
>UniRef50_A3U5U4 Cluster: Tryptophan 2,3-dioxygenase family protein;
n=5; Bacteroidetes|Rep: Tryptophan 2,3-dioxygenase
family protein - Croceibacter atlanticus HTCC2559
Length = 323
Score = 64.1 bits (149), Expect = 3e-09
Identities = 46/127 (36%), Positives = 71/127 (55%), Gaps = 1/127 (0%)
Frame = +1
Query: 181 NEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRA 360
+E + Y +Y+ LD LLS Q ++ P DE +FI HQ EL+FK II E +
Sbjct: 35 HERYLTYWDYIHLDTLLSLQ---IPKTHFP--DEEIFIGYHQITELYFKLIIHEQ---KQ 86
Query: 361 LLNVEGLDESHTMEILKRLNRIVLILKLLVDQV-MILETMTPLDFMDFRHYLRPASGFQS 537
+++ +G +E + R+NR ++L+D +++ M F+ FR L PASGFQS
Sbjct: 87 IIDDKGQKAEFFIEKITRINRY---FRILIDSFDVMIRGMEREQFLKFRMSLLPASGFQS 143
Query: 538 LQFRLLE 558
QFR++E
Sbjct: 144 AQFRMIE 150
>UniRef50_Q50EC4 Cluster: Putative oxidoreductase; n=1; Streptomyces
filamentosus|Rep: Putative oxidoreductase - Streptomyces
filamentosus (Streptomyces roseosporus)
Length = 245
Score = 63.7 bits (148), Expect = 4e-09
Identities = 45/126 (35%), Positives = 68/126 (53%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
YGE L L+ LL+ + A + PV LF+ THQ+ E+WF ++ ++ +RA L +
Sbjct: 26 YGELLRLEDLLNVAHLRDAAA--PV----LFLATHQSAEIWFGIVLRHLEEIRAALTDD- 78
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
D + +L RL I +LLV +L T++ +F R L ASGFQS Q+R +E
Sbjct: 79 -DPDTALHLLPRLPE---IFELLVRHFDMLATLSTEEFGKIRAGLGTASGFQSAQYREIE 134
Query: 559 NKLGLK 576
GL+
Sbjct: 135 FLCGLR 140
>UniRef50_Q4VPT1 Cluster: Tryptophan 2,3-dioxygenase; n=2;
Myxococcus xanthus|Rep: Tryptophan 2,3-dioxygenase -
Myxococcus xanthus
Length = 282
Score = 61.7 bits (143), Expect = 2e-08
Identities = 46/130 (35%), Positives = 63/130 (48%), Gaps = 1/130 (0%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
Y YL LLS Q + + + HDE +F + HQA ELW K + S A+ V
Sbjct: 37 YEVYLKTPTLLSLQ---APDGERVAHDELMFQVVHQAQELWLK-----LASREAVEVVAE 88
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
LD RL RI +L+ + ++ ILETMTP + R L SG +S + +L
Sbjct: 89 LDRDALWAASSRLERICRVLQAVKQELAILETMTPDTYQVIRRSLGNGSGQESPGYNMLR 148
Query: 559 N-KLGLKQAL 585
LGL+ AL
Sbjct: 149 RVALGLEGAL 158
>UniRef50_Q11V86 Cluster: Tryptophan 2,3-dioxygenase; n=1; Cytophaga
hutchinsonii ATCC 33406|Rep: Tryptophan 2,3-dioxygenase
- Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB
9469)
Length = 330
Score = 61.7 bits (143), Expect = 2e-08
Identities = 46/140 (32%), Positives = 73/140 (52%), Gaps = 3/140 (2%)
Frame = +1
Query: 148 EINGQEGA-HLGNEAGMLYGEYLMLDKLLSAQRMLSAESSK-PVHDEHLFIITHQAYELW 321
E +GQ+ A HL G+L YL + + +L+ ++ + P DE +FI+ HQ EL+
Sbjct: 24 EKDGQDVATHL---EGLLNSNYLKYWDYIRLESLLTLQNPRTPYPDEMVFIVYHQITELY 80
Query: 322 FKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLD-FMD 498
FK ++ E++ V+ + G LKR+ R L+ I+ D F+
Sbjct: 81 FKLVMHELNQVKTADQLTG------PVFLKRIERCNWYFGQLISSFDIISVGLDQDQFLK 134
Query: 499 FRHYLRPASGFQSLQFRLLE 558
FR L PASGFQS+Q+R++E
Sbjct: 135 FRVALTPASGFQSVQYRMVE 154
>UniRef50_A3XQC2 Cluster: Tryptophan 2,3-dioxygenase; n=9;
Bacteroidetes|Rep: Tryptophan 2,3-dioxygenase -
Leeuwenhoekiella blandensis MED217
Length = 316
Score = 61.7 bits (143), Expect = 2e-08
Identities = 43/121 (35%), Positives = 62/121 (51%), Gaps = 1/121 (0%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
Y +Y+ +D LLS Q + + DE +FI+ HQ EL FK I++E++ V
Sbjct: 42 YWDYIQVDSLLSLQNQRTL-----LPDEMVFIMYHQINELLFKMILWELEQVAYE----- 91
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMIL-ETMTPLDFMDFRHYLRPASGFQSLQFRLL 555
E T ++LNRI +L I+ E M ++ FR L PASGFQS Q+R +
Sbjct: 92 -QELTTAFFSEKLNRISRYFDMLTSSFNIMREGMNMEQYLKFRRTLSPASGFQSAQYRYI 150
Query: 556 E 558
E
Sbjct: 151 E 151
>UniRef50_A0M172 Cluster: Tryptophan 2,3-dioxygenase; n=3;
Flavobacteriales|Rep: Tryptophan 2,3-dioxygenase -
Gramella forsetii (strain KT0803)
Length = 302
Score = 60.9 bits (141), Expect = 3e-08
Identities = 41/120 (34%), Positives = 65/120 (54%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
Y +Y+ ++ LLS QR + DE +FI+ HQ EL K ++ E+ + L+ +
Sbjct: 34 YWDYIGVETLLSLQRPRTN-----FKDEEIFIMYHQMTELLLKMLLHEI---KQLVETDS 85
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
E ++ + R+NR V +L D ++ + M D+ FR L PASGFQS+QFR +E
Sbjct: 86 FSEEIWLDKINRMNRYVSMLINSFD--IMKDGMDYEDYNRFRTALAPASGFQSVQFRYIE 143
>UniRef50_Q47RF8 Cluster: Putative tryptophan 2,3-dioxygenase; n=1;
Thermobifida fusca YX|Rep: Putative tryptophan
2,3-dioxygenase - Thermobifida fusca (strain YX)
Length = 286
Score = 55.2 bits (127), Expect = 1e-06
Identities = 49/160 (30%), Positives = 70/160 (43%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEG 378
Y Y + LLS QR + E + E F++ Q EL F I E + R +
Sbjct: 30 YAHYTAVSTLLSLQRPRTEEPA-----ETTFLVATQVMELLFALIRHEWEQAR-----DA 79
Query: 379 LDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLE 558
+D L L R +L + +L MTP +F FR L ASGFQS +R LE
Sbjct: 80 VDADDVPAALAALRRGHKAQDVLAESWELLAPMTPTEFNRFRDQLGEASGFQSYGYRHLE 139
Query: 559 NKLGLKQALRVKYNQNYQTVFGDDPEAMDSLQKSEQEPAL 678
LG K A ++ ++ DP L+++ EP+L
Sbjct: 140 FLLGNKSAAMIRPHR-------ADPHVSAELERALAEPSL 172
>UniRef50_Q7NIX4 Cluster: Glr2058 protein; n=2; Cyanobacteria|Rep:
Glr2058 protein - Gloeobacter violaceus
Length = 299
Score = 54.8 bits (126), Expect = 2e-06
Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 5/125 (4%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVE- 375
Y Y L+ LL+ ++ ++A DE LFI HQ E+ F Q+I +++ A L +
Sbjct: 24 YWHYHRLEALLACKQPITASQ-----DEDLFIAVHQICEVAFHQMIGDLERTLAALAIAL 78
Query: 376 GLDESH----TMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQ 543
DE T+E L R+V + +++ + IL +M F +FR + P SGFQS Q
Sbjct: 79 DADEERPVGDTVEACYFLERVVRLYEVVNVTMPILVSMRA--FGEFRSAIGPTSGFQSFQ 136
Query: 544 FRLLE 558
FR LE
Sbjct: 137 FRHLE 141
>UniRef50_Q82ET7 Cluster: Putative tryptophan 2,3-dioxygenase; n=3;
Streptomyces|Rep: Putative tryptophan 2,3-dioxygenase -
Streptomyces avermitilis
Length = 281
Score = 54.4 bits (125), Expect = 2e-06
Identities = 44/145 (30%), Positives = 63/145 (43%)
Frame = +1
Query: 148 EINGQEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFK 327
E + E HL Y +Y+ D L Q LS + E +F++T Q ELWF
Sbjct: 9 EASEPETPHLDFAGTTPYEDYVQADVLTHLQHTLSDDPG-----EMVFLVTTQVMELWFT 63
Query: 328 QIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRH 507
I+ E ++ L + + + + L R V L+ L L +TP F +R
Sbjct: 64 VIVHEWETAANALRGDDIPVA-----VAALKRSVRELEALNASWRPLSQLTPAQFNSYRS 118
Query: 508 YLRPASGFQSLQFRLLENKLGLKQA 582
L SGFQS +R +E LG K A
Sbjct: 119 ALGEGSGFQSAMYRRMEFLLGEKAA 143
>UniRef50_A1G3A0 Cluster: Putative uncharacterized protein; n=1;
Salinispora arenicola CNS205|Rep: Putative
uncharacterized protein - Salinispora arenicola CNS205
Length = 236
Score = 53.2 bits (122), Expect = 6e-06
Identities = 39/122 (31%), Positives = 62/122 (50%), Gaps = 1/122 (0%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESSKPVH-DEHLFIITHQAYELWFKQIIFEVDSVRALLNVE 375
Y Y+ LD L QR S++ +H DE LF + HQ+ ELW K E+ A+ VE
Sbjct: 17 YARYMRLDALFDLQR----PSAEMIHRDELLFQVVHQSTELWLKLAATEL--TEAVARVE 70
Query: 376 GLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLL 555
D + E L L R L ++L+ D + + ++P+DF + L SG +S +R +
Sbjct: 71 AGDPA-AAEAL--LGRATLAVRLVTDHLEMFRYLSPVDFQAMQPALGNGSGAESPGWRRI 127
Query: 556 EN 561
++
Sbjct: 128 QS 129
>UniRef50_A1GDT5 Cluster: Tryptophan 2,3-dioxygenase; n=2;
Salinispora|Rep: Tryptophan 2,3-dioxygenase -
Salinispora arenicola CNS205
Length = 298
Score = 52.4 bits (120), Expect = 1e-05
Identities = 46/148 (31%), Positives = 67/148 (45%)
Frame = +1
Query: 241 RMLSAESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLN 420
R+ + SS P E F++ Q EL+F E+ + LL + + E+ L L
Sbjct: 54 RLQAPLSSDP--GEMSFLVISQIMELYFNLTCHELRETQQLLRADRVREA-----LSPLR 106
Query: 421 RIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYN 600
R L L L L MTP DF FR+ L SGFQS +R LE LGL+ ++
Sbjct: 107 RAALHLDGLNAAWRSLRWMTPADFNRFRNLLGEGSGFQSAMYRHLELLLGLRDPALIRPF 166
Query: 601 QNYQTVFGDDPEAMDSLQKSEQEPALLA 684
+ V + A+++ + ALLA
Sbjct: 167 RRQSEVHAELTAALNAPSLWDDVLALLA 194
>UniRef50_A1G3A1 Cluster: Putative uncharacterized protein; n=1;
Salinispora arenicola CNS205|Rep: Putative
uncharacterized protein - Salinispora arenicola CNS205
Length = 409
Score = 51.2 bits (117), Expect = 2e-05
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 1/135 (0%)
Frame = +1
Query: 160 QEGAHLGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVHDEHLFIITHQAYELWFKQIIF 339
QEG + A L+ + LD + + LS HDE+LF+ QAYE F +
Sbjct: 176 QEGEPT-SAAATLHAVAVDLDSVGALPLRLSMLPVHVTHDEYLFLRVLQAYECVFAGV-- 232
Query: 340 EVDSVRALLNVEGLDESH-TMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLR 516
D +RA++ G+D++ + L+ ++L L +L TM P F FR Y
Sbjct: 233 -ADELRAVIAAIGVDDARAAADRLEYARNLILNAGPLFS---LLATMQPKSFQTFRQYTE 288
Query: 517 PASGFQSLQFRLLEN 561
AS QS ++L+E+
Sbjct: 289 GASAIQSRSYKLVES 303
>UniRef50_Q7N6V3 Cluster: Similarities with putative oxidoreductase;
n=1; Photorhabdus luminescens subsp. laumondii|Rep:
Similarities with putative oxidoreductase - Photorhabdus
luminescens subsp. laumondii
Length = 233
Score = 50.8 bits (116), Expect = 3e-05
Identities = 39/130 (30%), Positives = 63/130 (48%), Gaps = 1/130 (0%)
Frame = +1
Query: 175 LGNEAGMLYGEYLMLDKLLSAQRMLSAESSKPVH-DEHLFIITHQAYELWFKQIIFEVDS 351
L E Y +Y+ + LL+ Q K +H DE LF + HQ+ ELW K + +
Sbjct: 12 LSGEGDSDYEKYMRIPTLLNLQ----VTPEKMLHRDELLFQVVHQSTELWLK--LSNNEL 65
Query: 352 VRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGF 531
A+ + D E++KR + + +L+ Q+ + + MTP DF R L SGF
Sbjct: 66 AEAIKKLSKKDFVAATELIKRSSYPI---ELITKQLEMFKYMTPYDFQKVRPALGNGSGF 122
Query: 532 QSLQFRLLEN 561
+S +R L++
Sbjct: 123 ESPGWRRLQS 132
>UniRef50_Q0LUG5 Cluster: Tryptophan 2,3-dioxygenase; n=1;
Caulobacter sp. K31|Rep: Tryptophan 2,3-dioxygenase -
Caulobacter sp. K31
Length = 311
Score = 49.6 bits (113), Expect = 7e-05
Identities = 42/136 (30%), Positives = 66/136 (48%)
Frame = +1
Query: 274 HDEHLFIITHQAYELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVD 453
+DE FI+ Q EL F+ I +E+ +++ + + D + + + RL R L+LLV
Sbjct: 73 YDEFPFIVMTQVKELIFRSIHYELANIQQRIRDD--DLTGALVLAPRLRR---CLELLVK 127
Query: 454 QVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDP 633
+L T+T F FR L +SG QS +R +E LG K + N V+
Sbjct: 128 TWDVLSTITTQGFNAFRDQLGTSSGQQSYAYRHVEFILGNKSRRLAAAHANNPDVYPAIA 187
Query: 634 EAMDSLQKSEQEPALL 681
EA++S + ALL
Sbjct: 188 EALNSPSLYDDAIALL 203
>UniRef50_Q4US93 Cluster: Tryptophan 2,3-dioxygenase; n=3;
Proteobacteria|Rep: Tryptophan 2,3-dioxygenase -
Xanthomonas campestris pv. campestris (strain 8004)
Length = 270
Score = 44.4 bits (100), Expect = 0.003
Identities = 21/39 (53%), Positives = 26/39 (66%)
Frame = +1
Query: 475 MTPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRV 591
MT DF++FR L PASGFQS Q R +E LGL+ R+
Sbjct: 1 MTARDFLEFRERLAPASGFQSAQLREIEILLGLEDTQRI 39
>UniRef50_Q82Y87 Cluster: Putative dioxygenase; n=1; Streptomyces
avermitilis|Rep: Putative dioxygenase - Streptomyces
avermitilis
Length = 281
Score = 39.5 bits (88), Expect = 0.076
Identities = 39/146 (26%), Positives = 64/146 (43%), Gaps = 4/146 (2%)
Frame = +1
Query: 199 YGEYLMLDKLLSAQRMLSAESS--KPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLNV 372
Y EY+ D++L ++SA+++ DE F H EL Q++ ++ L
Sbjct: 58 YSEYVGADQILDLGFVVSADAAGASAKADELHFKRIHMESELSLAQVLTDMHCAVDFLK- 116
Query: 373 EGLDESHTMEILKRLNRIVLILKLLVDQVMILET--MTPLDFMDFRHYLRPASGFQSLQF 546
++ + L+R I+K + ++ +L T F +FR L PASG QS F
Sbjct: 117 ---PQTDVQKARFHLDRTAGIIKGMEAKLNLLRPPYFTQERFEEFRDLLAPASGAQSASF 173
Query: 547 RLLENKLGLKQALRVKYNQNYQTVFG 624
+ + LGL+ Y Q V G
Sbjct: 174 ARVRHFLGLEGTESPIYKQFINAVAG 199
>UniRef50_Q03WD2 Cluster: Phosphoglycerol transferase related
protein, alkaline phosphatase superfamily; n=1;
Leuconostoc mesenteroides subsp. mesenteroides ATCC
8293|Rep: Phosphoglycerol transferase related protein,
alkaline phosphatase superfamily - Leuconostoc
mesenteroides subsp. mesenteroides (strain ATCC 8293
/NCDO 523)
Length = 635
Score = 37.1 bits (82), Expect = 0.40
Identities = 35/118 (29%), Positives = 62/118 (52%), Gaps = 8/118 (6%)
Frame = +1
Query: 361 LLNV--EGLDESHTMEILKRLNRI-VLILKLLVDQVMILETMTPLDFMDFRHYLRPASGF 531
L+NV E + E+ E+ N I +L +KL++ V+IL M L F+ +R F
Sbjct: 105 LINVRQEAITEASLQEVTAFGNLIGMLDIKLVIAFVVILIVMAVLLFIIYRRSKWIV--F 162
Query: 532 QSLQFR---LLENKLGLKQALRVKYNQNYQTVF--GDDPEAMDSLQKSEQEPALLALI 690
+S+++R ++ + L L ++ +QN +T GDDP+ DSL + ++AL+
Sbjct: 163 RSIRWRAVLMIISILALVPFFQINSDQNKETFIKLGDDPKVWDSLYDAVSNGGIVALL 220
>UniRef50_Q4Q0S9 Cluster: Putative uncharacterized protein; n=3;
Leishmania|Rep: Putative uncharacterized protein -
Leishmania major
Length = 1207
Score = 35.1 bits (77), Expect = 1.6
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 2/85 (2%)
Frame = -2
Query: 465 NHHLIHQQFQDEHNPVESLQYLHGVAFVQAFHVK*CPHRIHFKYYLLEPEFVGLV--CDD 292
NH L+ + N + YL GV + + C +H Y L F+ + C
Sbjct: 399 NHELLTNDTPTDPNREVTNWYLSGVRSLGSLKQLRC---LHILYTPLHEAFLQALTTCSS 455
Query: 291 EEMLIVYRFRGLSAEHPLRRQQFIQ 217
E +I++R RG+ + PLRR Q +Q
Sbjct: 456 LECIILHRCRGVRSLEPLRRLQHLQ 480
>UniRef50_Q389X9 Cluster: Putative uncharacterized protein; n=1;
Trypanosoma brucei|Rep: Putative uncharacterized protein
- Trypanosoma brucei
Length = 1024
Score = 35.1 bits (77), Expect = 1.6
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Frame = -3
Query: 395 VWLSSKPSTLS-NALTESTSNIICLNQSS*AWCVMMKRCSSCTGLEDSALSILC 237
VW+S P LS ++L +S +++CL S A V R + +ED A S +C
Sbjct: 128 VWISVHPDALSPHSLAQSLYSLVCLEYSDSASVVCAVRQQLLSAMEDMAASSIC 181
>UniRef50_A1Z9H0 Cluster: CG6280-PA; n=2; Sophophora|Rep: CG6280-PA
- Drosophila melanogaster (Fruit fly)
Length = 1093
Score = 34.7 bits (76), Expect = 2.2
Identities = 18/50 (36%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Frame = -2
Query: 504 PEIHEVERCHRL-QNHHLIHQQFQDEHNPVESLQYL--HGVAFVQAFHVK 364
PE H + H++ Q+HH+IH + Q EH P +L H +Q +HV+
Sbjct: 723 PEQHPEPQIHQIHQDHHIIHHEPQPEHEPHLHQDHLEHHEHPSLQPYHVE 772
>UniRef50_Q54X30 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 919
Score = 33.5 bits (73), Expect = 5.0
Identities = 26/105 (24%), Positives = 46/105 (43%)
Frame = +1
Query: 286 LFIITHQAYELWFKQIIFEVDSVRALLNVEGLDESHTMEILKRLNRIVLILKLLVDQVMI 465
LFII LW K +I E+ SV +++ E +DE + + ++ L + Q I
Sbjct: 435 LFIIWTVTCILWIKPLIKEIRSVESVVLKELVDEENIKDTSSDIDIDTLDKLTIKPQYGI 494
Query: 466 LETMTPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYN 600
++ PL + P +G Q +Q L ++ + + YN
Sbjct: 495 IQPEEPLRIAMRKFNKNPETGIQFIQENNLLSQTPYRDIVTFLYN 539
>UniRef50_Q2IZV6 Cluster: Generic methyltransferase; n=1;
Rhodopseudomonas palustris HaA2|Rep: Generic
methyltransferase - Rhodopseudomonas palustris (strain
HaA2)
Length = 201
Score = 33.1 bits (72), Expect = 6.6
Identities = 13/36 (36%), Positives = 23/36 (63%)
Frame = +1
Query: 259 SSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALL 366
++ P+HD+H+F+ H+ + K + FEV S+ LL
Sbjct: 149 TNHPLHDQHIFVPNHELVGYFLKLVGFEVVSIDYLL 184
>UniRef50_Q08VX1 Cluster: Tryptophan 2,3-dioxygenase; n=1;
Stigmatella aurantiaca DW4/3-1|Rep: Tryptophan
2,3-dioxygenase - Stigmatella aurantiaca DW4/3-1
Length = 307
Score = 33.1 bits (72), Expect = 6.6
Identities = 22/59 (37%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Frame = +1
Query: 412 RLNRIVLILKLLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLENKL-GLKQAL 585
RL R++ ++ LV ++ ILETMTP + R L SG +S + L GL+ AL
Sbjct: 21 RLERMLRAMRCLVAEMNILETMTPDTYQIIRRSLGNGSGQESPGYNALRLAADGLEAAL 79
>UniRef50_A3VH76 Cluster: Putative uncharacterized protein; n=1;
Rhodobacterales bacterium HTCC2654|Rep: Putative
uncharacterized protein - Rhodobacterales bacterium
HTCC2654
Length = 303
Score = 33.1 bits (72), Expect = 6.6
Identities = 20/72 (27%), Positives = 35/72 (48%)
Frame = -2
Query: 489 VERCHRLQNHHLIHQQFQDEHNPVESLQYLHGVAFVQAFHVK*CPHRIHFKYYLLEPEFV 310
+ R HR Q+ L+ + +D + E L++ +A Q F R+H L P+
Sbjct: 166 IRRGHRAQDVPLVIELLEDARHAGEHLEHRRQIAGDQGF-----AGRLHLVQDQLHPKLA 220
Query: 309 GLVCDDEEMLIV 274
+V DDE+ L++
Sbjct: 221 RVVLDDEQQLVM 232
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 620,717,007
Number of Sequences: 1657284
Number of extensions: 11403700
Number of successful extensions: 30819
Number of sequences better than 10.0: 50
Number of HSP's better than 10.0 without gapping: 29762
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 30745
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 54132236449
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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