Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte4o21
(719 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 200 5e-51
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 200 5e-51
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 200 5e-51
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 197 4e-50
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 189 1e-47
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 188 1e-47
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 188 2e-47
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 188 2e-47
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 187 4e-47
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 187 4e-47
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 180 3e-45
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 140 5e-33
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 140 5e-33
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 140 5e-33
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 140 5e-33
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 123 6e-28
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 122 1e-27
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 116 6e-26
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 116 6e-26
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 77 5e-14
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 73 1e-12
AL139410-3|CAI12718.1| 902|Homo sapiens RUN and SH3 domain cont... 31 3.1
AL139410-2|CAI12719.1| 796|Homo sapiens RUN and SH3 domain cont... 31 3.1
X90568-1|CAA62188.1|26926|Homo sapiens titin protein. 31 4.1
AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein. 31 4.1
AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein. 31 4.1
M81601-1|AAA61138.1| 301|Homo sapiens transcription elongation ... 30 9.6
BC105696-1|AAI05697.1| 376|Homo sapiens KLHL30 protein protein. 30 9.6
AK098479-1|BAC05314.1| 353|Homo sapiens protein ( Homo sapiens ... 30 9.6
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 200 bits (487), Expect = 5e-51
Identities = 100/195 (51%), Positives = 134/195 (68%), Gaps = 3/195 (1%)
Frame = +3
Query: 138 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 314
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 315 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 488
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 489 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 668
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 669 PTHACKEHNHVFPLL 713
THAC E+NH+FPLL
Sbjct: 199 KTHACYEYNHIFPLL 213
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 200 bits (487), Expect = 5e-51
Identities = 100/195 (51%), Positives = 134/195 (68%), Gaps = 3/195 (1%)
Frame = +3
Query: 138 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 314
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 315 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 488
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 489 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 668
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 669 PTHACKEHNHVFPLL 713
THAC E+NH+FPLL
Sbjct: 199 KTHACYEYNHIFPLL 213
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 200 bits (487), Expect = 5e-51
Identities = 100/195 (51%), Positives = 134/195 (68%), Gaps = 3/195 (1%)
Frame = +3
Query: 138 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 314
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 315 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 488
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 489 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 668
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 669 PTHACKEHNHVFPLL 713
THAC E+NH+FPLL
Sbjct: 199 KTHACYEYNHIFPLL 213
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 197 bits (480), Expect = 4e-50
Identities = 99/195 (50%), Positives = 133/195 (68%), Gaps = 3/195 (1%)
Frame = +3
Query: 138 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 314
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 315 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 488
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 489 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 668
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +E TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLY 198
Query: 669 PTHACKEHNHVFPLL 713
THAC E+NH+FPLL
Sbjct: 199 KTHACYEYNHIFPLL 213
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 189 bits (460), Expect = 1e-47
Identities = 99/226 (43%), Positives = 138/226 (61%), Gaps = 5/226 (2%)
Frame = +3
Query: 51 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARY 230
E+ + + + +P SG DK +G N RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGN--KGSNK-REAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 231 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 401
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 402 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 575
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 576 YKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLL 713
YK+G+P+P VEYT+EE TWGVVFR+L++LYPTHAC+E+ FPLL
Sbjct: 201 YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLL 246
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 188 bits (459), Expect = 1e-47
Identities = 89/175 (50%), Positives = 117/175 (66%), Gaps = 5/175 (2%)
Frame = +3
Query: 204 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 380
+E G L + L IF VNL HIESR S RR +E V+C+ L LK +
Sbjct: 24 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDILHLLKSHTN 83
Query: 381 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 548
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 84 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 143
Query: 549 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLL 713
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF++L +LYPTHAC+E+ PLL
Sbjct: 144 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLL 198
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 188 bits (458), Expect = 2e-47
Identities = 98/220 (44%), Positives = 135/220 (61%), Gaps = 5/220 (2%)
Frame = +3
Query: 69 TAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSS 248
T ++ +P SG DK G+ RE + T ++ S +E G L + L +F
Sbjct: 38 TFLKLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQE 92
Query: 249 HGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISRNYKDNR 419
VN+ HIESR S RR E V+CE G +F ++ LK + LN + +
Sbjct: 93 KRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEE 152
Query: 420 SA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEP 593
VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A YK+G+P
Sbjct: 153 ELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQP 212
Query: 594 LPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLL 713
+P VEYT+EE TWGVVFR+L++LYPTHAC+E+ FPLL
Sbjct: 213 IPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLL 252
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 188 bits (458), Expect = 2e-47
Identities = 98/226 (43%), Positives = 137/226 (60%), Gaps = 5/226 (2%)
Frame = +3
Query: 51 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARY 230
E+ + + + +P SG DK G+ RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 231 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 401
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 402 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 575
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 576 YKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLL 713
YK+G+P+P VEYT+EE TWGVVFR+L++LYPTHAC+E+ FPLL
Sbjct: 201 YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLL 246
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 187 bits (455), Expect = 4e-47
Identities = 88/175 (50%), Positives = 116/175 (66%), Gaps = 5/175 (2%)
Frame = +3
Query: 204 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 380
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 381 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 548
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 549 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLL 713
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF++L +LYPTHAC+E+ PLL
Sbjct: 146 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLL 200
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 187 bits (455), Expect = 4e-47
Identities = 88/175 (50%), Positives = 116/175 (66%), Gaps = 5/175 (2%)
Frame = +3
Query: 204 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 380
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 381 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 548
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 549 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLL 713
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF++L +LYPTHAC+E+ PLL
Sbjct: 146 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLL 200
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 180 bits (439), Expect = 3e-45
Identities = 86/175 (49%), Positives = 115/175 (65%), Gaps = 5/175 (2%)
Frame = +3
Query: 204 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 380
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQLNDIFHLLKSHTN 85
Query: 381 YLNIISR-NY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 548
L++ N+ ++ +VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVTPPDNFTMKEEGMESVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 549 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLL 713
KYFAD A +YK+G+P+P VE+T+EE+ TWG VFR+L +LYPTHAC+E+ PLL
Sbjct: 146 KYFADSAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLL 200
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 140 bits (339), Expect = 5e-33
Identities = 73/183 (39%), Positives = 106/183 (57%), Gaps = 5/183 (2%)
Frame = +3
Query: 180 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 347
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 111 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 169
Query: 348 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 524
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 170 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 222
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 704
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 223 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 282
Query: 705 PLL 713
LL
Sbjct: 283 ALL 285
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 140 bits (339), Expect = 5e-33
Identities = 73/183 (39%), Positives = 106/183 (57%), Gaps = 5/183 (2%)
Frame = +3
Query: 180 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 347
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 348 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 524
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 704
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 255
Query: 705 PLL 713
LL
Sbjct: 256 ALL 258
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 140 bits (339), Expect = 5e-33
Identities = 73/183 (39%), Positives = 106/183 (57%), Gaps = 5/183 (2%)
Frame = +3
Query: 180 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 347
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 115 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 173
Query: 348 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 524
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 174 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 226
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 704
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 227 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 286
Query: 705 PLL 713
LL
Sbjct: 287 ALL 289
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 140 bits (339), Expect = 5e-33
Identities = 73/183 (39%), Positives = 106/183 (57%), Gaps = 5/183 (2%)
Frame = +3
Query: 180 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 347
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 348 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 524
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 704
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 255
Query: 705 PLL 713
LL
Sbjct: 256 ALL 258
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 123 bits (297), Expect = 6e-28
Identities = 71/187 (37%), Positives = 102/187 (54%), Gaps = 5/187 (2%)
Frame = +3
Query: 51 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARY 230
E+ + + + +P SG DK G+ RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 231 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 401
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 402 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 575
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 576 YKHGEPL 596
YK+G L
Sbjct: 201 YKYGPRL 207
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 122 bits (295), Expect = 1e-27
Identities = 62/131 (47%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
Frame = +3
Query: 204 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 380
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 381 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 548
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLNEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 549 KYFADIAYNYK 581
KYFAD+A NYK
Sbjct: 146 KYFADLAMNYK 156
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 116 bits (280), Expect = 6e-26
Identities = 60/157 (38%), Positives = 92/157 (58%), Gaps = 5/157 (3%)
Frame = +3
Query: 180 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 347
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 88 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 146
Query: 348 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 524
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 147 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 199
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 635
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 200 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 236
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 116 bits (280), Expect = 6e-26
Identities = 60/157 (38%), Positives = 92/157 (58%), Gaps = 5/157 (3%)
Frame = +3
Query: 180 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 347
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 348 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 524
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 635
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 232
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 77.4 bits (182), Expect = 5e-14
Identities = 30/45 (66%), Positives = 37/45 (82%)
Frame = +3
Query: 501 DSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 635
D DHPGF+D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 45
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 72.9 bits (171), Expect = 1e-12
Identities = 29/44 (65%), Positives = 36/44 (81%)
Frame = +3
Query: 501 DSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVAT 632
D DHPGF+D VYR RRK A+IA+ Y+HG+P+P VEYT EE+AT
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
>AL139410-3|CAI12718.1| 902|Homo sapiens RUN and SH3 domain
containing 1 protein.
Length = 902
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/50 (34%), Positives = 25/50 (50%)
Frame = +3
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPT 674
+PV F ++A K G LP V K++ + W +VF TEL P+
Sbjct: 306 EPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPS 355
>AL139410-2|CAI12719.1| 796|Homo sapiens RUN and SH3 domain
containing 1 protein.
Length = 796
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/50 (34%), Positives = 25/50 (50%)
Frame = +3
Query: 525 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPT 674
+PV F ++A K G LP V K++ + W +VF TEL P+
Sbjct: 306 EPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPS 355
>X90568-1|CAA62188.1|26926|Homo sapiens titin protein.
Length = 26926
Score = 31.1 bits (67), Expect = 4.1
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 117 PKLMEGG----NYIREGRDSTKSTWLLIS 191
P L++GG NY+ E RD+TK TW ++S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
>AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein.
Length = 30000
Score = 31.1 bits (67), Expect = 4.1
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 117 PKLMEGG----NYIREGRDSTKSTWLLIS 191
P L++GG NY+ E RD+TK TW ++S
Sbjct: 28315 PPLIDGGSPIINYVIEKRDATKRTWSVVS 28343
>AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein.
Length = 26926
Score = 31.1 bits (67), Expect = 4.1
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 117 PKLMEGG----NYIREGRDSTKSTWLLIS 191
P L++GG NY+ E RD+TK TW ++S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
>M81601-1|AAA61138.1| 301|Homo sapiens transcription elongation
factor SII protein.
Length = 301
Score = 29.9 bits (64), Expect = 9.6
Identities = 17/61 (27%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Frame = +3
Query: 42 PATEKEMDITAKQIEQPTSGSPPDKPKLMEGGNYI-REGRDSTKSTWLLISPVAPDEAGS 218
P+TEK++D K+ + SP + + GN R+ + + T+L P AP + S
Sbjct: 80 PSTEKDLDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYLSSFPRAPSTSDS 139
Query: 219 L 221
+
Sbjct: 140 V 140
>BC105696-1|AAI05697.1| 376|Homo sapiens KLHL30 protein protein.
Length = 376
Score = 29.9 bits (64), Expect = 9.6
Identities = 15/36 (41%), Positives = 21/36 (58%)
Frame = -3
Query: 222 LTSQPRRVRLVKSEAKLIW*NHDPRGCSCHLPSILA 115
L QP + RL EA + W HDP+ + HLP +L+
Sbjct: 170 LQVQPEQSRL---EALMRWVRHDPQARAVHLPELLS 202
>AK098479-1|BAC05314.1| 353|Homo sapiens protein ( Homo sapiens
cDNA FLJ25613 fis, clone STM01546. ).
Length = 353
Score = 29.9 bits (64), Expect = 9.6
Identities = 21/88 (23%), Positives = 36/88 (40%)
Frame = +3
Query: 3 FYISHSR*EHTPLPATEKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWL 182
F S + TPL A D+ Q+ T P ++ GNYI G + L
Sbjct: 32 FLPSQDQERRTPLHAAAYVGDVPILQLLLITGFLHTSSPPSIKIGNYIPTGANVNAKDTL 91
Query: 183 LISPVAPDEAGSLARYLGIFSSHGVNLS 266
++P+ A + LG+ +H +++
Sbjct: 92 WLAPLHRAAASRNEKVLGLLLAHSADVN 119
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 125,134,858
Number of Sequences: 237096
Number of extensions: 3053670
Number of successful extensions: 8658
Number of sequences better than 10.0: 29
Number of HSP's better than 10.0 without gapping: 7941
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8643
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8455186714
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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