Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte4h06
(663 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P34896 Cluster: Serine hydroxymethyltransferase, cytoso... 251 1e-65
UniRef50_A4SBB9 Cluster: Serine hydroxymethyltransferase; n=11; ... 250 3e-65
UniRef50_Q5BJF5 Cluster: Serine hydroxymethyltransferase; n=3; E... 241 1e-62
UniRef50_P34897 Cluster: Serine hydroxymethyltransferase, mitoch... 241 1e-62
UniRef50_A2EAE3 Cluster: Serine hydroxymethyltransferase; n=1; T... 189 6e-47
UniRef50_Q9U638 Cluster: SHMT; n=5; Aconoidasida|Rep: SHMT - Pla... 183 3e-45
UniRef50_Q9LM59 Cluster: Serine hydroxymethyltransferase; n=21; ... 181 1e-44
UniRef50_Q7RQX7 Cluster: Serine hydroxymethyltransferase; n=4; P... 181 1e-44
UniRef50_O62585 Cluster: Serine hydroxymethyltransferase, cytoso... 180 2e-44
UniRef50_Q23KJ4 Cluster: Serine hydroxymethyltransferase family ... 169 7e-41
UniRef50_Q5C0V4 Cluster: SJCHGC07535 protein; n=1; Schistosoma j... 165 1e-39
UniRef50_A6PKY7 Cluster: Serine hydroxymethyltransferase; n=2; B... 159 7e-38
UniRef50_Q72IH2 Cluster: Serine hydroxymethyltransferase; n=6; B... 159 7e-38
UniRef50_Q9A8J6 Cluster: Serine hydroxymethyltransferase; n=42; ... 154 2e-36
UniRef50_Q8KC36 Cluster: Serine hydroxymethyltransferase; n=103;... 152 6e-36
UniRef50_Q9RYB2 Cluster: Serine hydroxymethyltransferase; n=43; ... 150 3e-35
UniRef50_Q6LHN7 Cluster: Serine hydroxymethyltransferase 2; n=27... 149 4e-35
UniRef50_Q11NZ7 Cluster: Serine hydroxymethyltransferase; n=6; B... 148 1e-34
UniRef50_Q98A81 Cluster: Serine hydroxymethyltransferase 2; n=4;... 144 1e-33
UniRef50_Q6G3L3 Cluster: Serine hydroxymethyltransferase; n=163;... 142 9e-33
UniRef50_Q62I16 Cluster: Serine hydroxymethyltransferase 1; n=45... 141 1e-32
UniRef50_Q89HS7 Cluster: Serine hydroxymethyltransferase; n=2; R... 139 5e-32
UniRef50_Q5CM80 Cluster: Serine hydroxymethyltransferase; n=2; C... 134 2e-30
UniRef50_UPI0000E49DF3 Cluster: PREDICTED: similar to serine hyd... 134 2e-30
UniRef50_Q8FQR1 Cluster: Serine hydroxymethyltransferase; n=37; ... 128 1e-28
UniRef50_Q8EWD1 Cluster: Serine hydroxymethyltransferase; n=14; ... 126 4e-28
UniRef50_Q9PJW0 Cluster: Serine hydroxymethyltransferase; n=8; C... 125 8e-28
UniRef50_A7D249 Cluster: Glycine hydroxymethyltransferase; n=1; ... 125 1e-27
UniRef50_Q9HPY5 Cluster: Serine hydroxymethyltransferase; n=79; ... 124 3e-27
UniRef50_Q057P9 Cluster: Serine hydroxymethyltransferase; n=3; G... 123 3e-27
UniRef50_Q183S3 Cluster: Serine hydroxymethyltransferase; n=1; C... 121 2e-26
UniRef50_A0CF19 Cluster: Chromosome undetermined scaffold_174, w... 111 1e-23
UniRef50_Q05FV9 Cluster: Serine hydroxymethyltransferase; n=1; C... 107 2e-22
UniRef50_A6MJY3 Cluster: Mitochondrial serine hydroxymethyltrans... 103 4e-21
UniRef50_O83349 Cluster: Serine hydroxymethyltransferase; n=18; ... 103 5e-21
UniRef50_Q12RK5 Cluster: Glycine hydroxymethyltransferase; n=2; ... 100 4e-20
UniRef50_O29406 Cluster: Serine hydroxymethyltransferase; n=6; E... 94 2e-18
UniRef50_Q8ZYF9 Cluster: Serine hydroxymethyltransferase; n=5; T... 87 4e-16
UniRef50_O23984 Cluster: Expressed sequence tag; n=7; Poaceae|Re... 83 6e-15
UniRef50_Q8TZ19 Cluster: Serine hydroxymethyltransferase; n=8; E... 83 6e-15
UniRef50_Q9YAH7 Cluster: Serine hydroxymethyltransferase; n=9; A... 82 1e-14
UniRef50_Q5CM83 Cluster: Serine hydroxymethyltransferase 2; n=2;... 79 7e-14
UniRef50_Q9HI38 Cluster: Serine hydroxymethyltransferase; n=5; T... 78 2e-13
UniRef50_Q883D8 Cluster: Serine hydroxymethyltransferase, putati... 76 7e-13
UniRef50_A6TST7 Cluster: Glycine hydroxymethyltransferase; n=1; ... 76 9e-13
UniRef50_A0RYP2 Cluster: Glycine/serine hydroxymethyltransferase... 72 1e-11
UniRef50_A0GN01 Cluster: Glycine hydroxymethyltransferase; n=1; ... 68 2e-10
UniRef50_Q2GRC5 Cluster: Putative uncharacterized protein; n=1; ... 68 2e-10
UniRef50_Q7XZ78 Cluster: Hydromethyl transferase; n=1; Griffiths... 62 2e-08
UniRef50_Q8IKR8 Cluster: Putative uncharacterized protein; n=1; ... 62 2e-08
UniRef50_A5K3J5 Cluster: Serine hydroxymethyltransferase, putati... 56 8e-07
UniRef50_Q7RRP9 Cluster: Serine hydroxymethyltransferase, mitoch... 51 2e-05
UniRef50_Q0GPG8 Cluster: BZIP transcription factor bZIP94; n=1; ... 49 1e-04
UniRef50_UPI00006DBC17 Cluster: hypothetical protein BdolA_01004... 46 0.001
UniRef50_A5P5T2 Cluster: Putative uncharacterized protein; n=3; ... 46 0.001
UniRef50_Q3JGP6 Cluster: Putative uncharacterized protein; n=10;... 37 0.38
UniRef50_Q0FXL6 Cluster: Serine hydroxymethyltransferase; n=1; F... 36 0.66
UniRef50_A0HCN5 Cluster: Putative uncharacterized protein; n=1; ... 36 0.66
UniRef50_Q7UVI4 Cluster: Putative deoxyribonuclease yabD; n=3; P... 35 1.5
UniRef50_Q8GGQ5 Cluster: Serine hydroxymethyltransferase; n=1; S... 35 1.5
UniRef50_Q0S5S0 Cluster: Glycine hydroxymethyltransferase; n=1; ... 34 3.5
UniRef50_Q9VEP4 Cluster: CG5225-PA; n=2; Drosophila melanogaster... 34 3.5
UniRef50_Q6ZT39 Cluster: CDNA FLJ44991 fis, clone BRAWH3008867; ... 34 3.5
UniRef50_Q97AK0 Cluster: Serine hydroxymethyltransferase; n=3; T... 34 3.5
UniRef50_O15026 Cluster: KIAA0309 protein; n=17; Eutheria|Rep: K... 33 4.6
UniRef50_UPI00006CE5B4 Cluster: hypothetical protein TTHERM_0014... 33 8.1
UniRef50_A6PKY5 Cluster: Putative uncharacterized protein; n=1; ... 33 8.1
UniRef50_Q5BWM4 Cluster: SJCHGC08526 protein; n=1; Schistosoma j... 33 8.1
UniRef50_Q6C6R0 Cluster: Similar to DEHA0C07986g Debaryomyces ha... 33 8.1
UniRef50_Q9NZR2 Cluster: Low-density lipoprotein receptor-relate... 33 8.1
>UniRef50_P34896 Cluster: Serine hydroxymethyltransferase,
cytosolic; n=86; root|Rep: Serine
hydroxymethyltransferase, cytosolic - Homo sapiens
(Human)
Length = 483
Score = 251 bits (615), Expect = 1e-65
Identities = 122/207 (58%), Positives = 147/207 (71%), Gaps = 1/207 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKAN-GQKVMYDLESKINQA 178
VAAGV+PSPFE+C +VTTTTHKTLRG RAG+IF+RKGV+SV G++++Y+LES IN A
Sbjct: 236 VAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSA 295
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTD 358
VFPGLQGGPHNH EF YQ QV+ N + L E L GY I TGG+D
Sbjct: 296 VFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSD 355
Query: 359 VHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKE 538
HL LVDLR G G AE+VLE CS+ACNKNT PGD SAL PSG+RLGTPALT+RGL E
Sbjct: 356 NHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLE 415
Query: 539 ADIDKVVDFIDRALKIGLEIIKVSGLK 619
D KV FI R +++ L+I +G++
Sbjct: 416 KDFQKVAHFIHRGIELTLQIQSDTGVR 442
>UniRef50_A4SBB9 Cluster: Serine hydroxymethyltransferase; n=11;
Viridiplantae|Rep: Serine hydroxymethyltransferase -
Ostreococcus lucimarinus CCE9901
Length = 525
Score = 250 bits (611), Expect = 3e-65
Identities = 117/216 (54%), Positives = 149/216 (68%), Gaps = 1/216 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VAAG +PSPF+Y D+VTTTTHK+LRGPR +IF+RKG + G +MYDLESKI+ AV
Sbjct: 273 VAAGEVPSPFDYADVVTTTTHKSLRGPRGAMIFYRKGEKGKDKKGNPIMYDLESKIDFAV 332
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPGLQGGPHNH EF YQ+QV+ N Q + L+ G + +GGTD
Sbjct: 333 FPGLQGGPHNHTIAGLAVALKQAASPEFKAYQRQVMSNMQAMANRLVQHGIKLVSGGTDN 392
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
HLAL+DLR +G+ G+ ERVLEL +ACNKNTVPGD+SA+ P G+R+GTPALT+RG E
Sbjct: 393 HLALLDLRPMGVDGSRVERVLELAHIACNKNTVPGDVSAMVPGGLRIGTPALTSRGFTEK 452
Query: 542 DIDKVVDFIDRALKIGLEI-IKVSGLKLVDFNKAIE 646
D ++V +FI R +KI ++ K G KL DF A+E
Sbjct: 453 DFEQVAEFIVRGIKIAQDVKSKSEGTKLKDFRAALE 488
>UniRef50_Q5BJF5 Cluster: Serine hydroxymethyltransferase; n=3;
Euarchontoglires|Rep: Serine hydroxymethyltransferase -
Homo sapiens (Human)
Length = 480
Score = 241 bits (590), Expect = 1e-62
Identities = 121/220 (55%), Positives = 151/220 (68%), Gaps = 1/220 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKAN-GQKVMYDLESKINQA 178
VAA VIPSPF++ DIVTTTTHKTLRG R+G+IF+RKGV++V G+++ Y E +IN A
Sbjct: 235 VAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFA 294
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTD 358
VFP LQGGPHNH F EY QV+KNA+ + + L+ RGYS+ +GGTD
Sbjct: 295 VFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTD 354
Query: 359 VHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKE 538
HL LVDLR GL GA AERVLEL S+ NKNT PGD SA+ P G+RLG PALT+R +E
Sbjct: 355 NHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFRE 414
Query: 539 ADIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEENAE 658
D +VVDFID + IGLE +K KL DF + +++E
Sbjct: 415 DDFRRVVDFIDEGVNIGLE-VKSKTAKLQDFKSFLLKDSE 453
>UniRef50_P34897 Cluster: Serine hydroxymethyltransferase,
mitochondrial precursor; n=160; Eukaryota|Rep: Serine
hydroxymethyltransferase, mitochondrial precursor - Homo
sapiens (Human)
Length = 504
Score = 241 bits (590), Expect = 1e-62
Identities = 121/220 (55%), Positives = 151/220 (68%), Gaps = 1/220 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKAN-GQKVMYDLESKINQA 178
VAA VIPSPF++ DIVTTTTHKTLRG R+G+IF+RKGV++V G+++ Y E +IN A
Sbjct: 259 VAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFA 318
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTD 358
VFP LQGGPHNH F EY QV+KNA+ + + L+ RGYS+ +GGTD
Sbjct: 319 VFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTD 378
Query: 359 VHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKE 538
HL LVDLR GL GA AERVLEL S+ NKNT PGD SA+ P G+RLG PALT+R +E
Sbjct: 379 NHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFRE 438
Query: 539 ADIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEENAE 658
D +VVDFID + IGLE +K KL DF + +++E
Sbjct: 439 DDFRRVVDFIDEGVNIGLE-VKSKTAKLQDFKSFLLKDSE 477
>UniRef50_A2EAE3 Cluster: Serine hydroxymethyltransferase; n=1;
Trichomonas vaginalis G3|Rep: Serine
hydroxymethyltransferase - Trichomonas vaginalis G3
Length = 451
Score = 189 bits (460), Expect = 6e-47
Identities = 100/217 (46%), Positives = 128/217 (58%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+AAG+ PSPFEY DIVTTTTHKTLRGPR ++FF+K + E KIN A+
Sbjct: 230 IAAGLYPSPFEYSDIVTTTTHKTLRGPRGALVFFKK--------------EYEKKINSAI 275
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FP LQGGPH H +F YQKQV+KN + LC+ L I +GGTD
Sbjct: 276 FPTLQGGPHLHQIAAIAVALKEAKSEDFRNYQKQVLKNIKALCDYLQQNNIDIVSGGTDS 335
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
H+AL+DLR + GA E VL+ + NKNT+PG G+R+G+PA+T+RGL E
Sbjct: 336 HMALIDLRRYNVDGARVEFVLDQMGITTNKNTIPG-----GSVGLRVGSPAMTSRGLDEN 390
Query: 542 DIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEEN 652
D K+ +FI + +KI EI SG KL DF K + N
Sbjct: 391 DFKKIAEFIVKGVKISKEIKSKSGKKLSDFKKLAKNN 427
>UniRef50_Q9U638 Cluster: SHMT; n=5; Aconoidasida|Rep: SHMT -
Plasmodium falciparum
Length = 442
Score = 183 bits (446), Expect = 3e-45
Identities = 93/217 (42%), Positives = 129/217 (59%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VA ++ +PF Y D+VTTTTHK LRGPR+ +IFF K K N ++ KIN +V
Sbjct: 216 VACNLLNNPFTYADVVTTTTHKILRGPRSALIFFNK-----KRNP-----GIDQKINSSV 265
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FP QGGPHN+ F EY KQV+ N++ L E L+ R + T GTD
Sbjct: 266 FPSFQGGPHNNKIAAVACQLKEVNTPFFKEYTKQVLLNSKALAECLLKRNLDLVTNGTDN 325
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
HL +VDLR + G+ + ++A NKNT+P D+ ++PSGIR+GTPALTTRG KE
Sbjct: 326 HLIVVDLRKYNITGSKLQETCNAINIALNKNTIPSDVDCVSPSGIRIGTPALTTRGCKEK 385
Query: 542 DIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEEN 652
D++ + D + +A+ + E+ + G KLVDF K + N
Sbjct: 386 DMEFIADMLLKAILLTDELQQKYGKKLVDFKKGLVNN 422
>UniRef50_Q9LM59 Cluster: Serine hydroxymethyltransferase; n=21;
Eukaryota|Rep: Serine hydroxymethyltransferase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 599
Score = 181 bits (441), Expect = 1e-44
Identities = 89/201 (44%), Positives = 125/201 (62%), Gaps = 6/201 (2%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVR----SVKANG--QKVMYDLES 163
VAA P+PF+YCDIVT+TTHK+LRGPR G+IF+++G++ S+ N + YD E
Sbjct: 353 VAAKESPNPFDYCDIVTSTTHKSLRGPRGGIIFYKRGLKPKKQSINLNHCESNIQYDFEE 412
Query: 164 KINQAVFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIA 343
KIN +VFP LQGGPHN+ E+ Y +QV KNA+ L LISR +
Sbjct: 413 KINFSVFPSLQGGPHNNHIAALAIALKQAASPEYKLYMRQVKKNAKALASALISRKCKLI 472
Query: 344 TGGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTT 523
TGGTD HL L DL +GL G E+V E+C + NK + + ++P G+R+G+PA+T+
Sbjct: 473 TGGTDNHLLLWDLTPLGLTGKVYEKVCEMCHITVNKVAIFSENGVISPGGVRIGSPAMTS 532
Query: 524 RGLKEADIDKVVDFIDRALKI 586
RG E + + + DF+ RA +I
Sbjct: 533 RGCLEPEFETMADFLYRAAQI 553
>UniRef50_Q7RQX7 Cluster: Serine hydroxymethyltransferase; n=4;
Plasmodium|Rep: Serine hydroxymethyltransferase -
Plasmodium yoelii yoelii
Length = 446
Score = 181 bits (441), Expect = 1e-44
Identities = 91/219 (41%), Positives = 129/219 (58%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+A G + +PF Y D+VTTTTHK LRGPR+ +IFF K K N +E KIN +V
Sbjct: 220 IACGNLNNPFLYADVVTTTTHKILRGPRSAMIFFNK-----KRNP-----GIEQKINSSV 269
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FP QGGPHN+ F Y KQV++N++ L + LI+ + T GTD
Sbjct: 270 FPSFQGGPHNNKIAAVACQLKEVQTESFKNYTKQVLENSKALAKFLINNNIDLVTNGTDN 329
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
H+ L+DLR G+ G+ + V +++ NKNT+P D ++P+G RLGTPA+TTRG KE
Sbjct: 330 HIVLIDLRKYGITGSKLQEVCNTINISINKNTIPSDNDCVSPNGARLGTPAMTTRGAKEN 389
Query: 542 DIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEENAE 658
D+ + D + +A+KI + + G KLV+F K + N E
Sbjct: 390 DMKFIADTLLKAIKIAASLQEKYGKKLVEFKKGLTNNPE 428
>UniRef50_O62585 Cluster: Serine hydroxymethyltransferase,
cytosolic; n=1; Encephalitozoon cuniculi|Rep: Serine
hydroxymethyltransferase, cytosolic - Encephalitozoon
cuniculi
Length = 460
Score = 180 bits (439), Expect = 2e-44
Identities = 93/216 (43%), Positives = 132/216 (61%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VA+G++ SPFE+CDIV TTT K LRGPR +IF+R R+V NG+ V DL+++IN AV
Sbjct: 223 VASGLMNSPFEHCDIVMTTTQKGLRGPRGALIFYR---RAVTKNGETV--DLDARINFAV 277
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FP LQGGPHNH EF EY ++V++N++ LC L S G I TGGTD
Sbjct: 278 FPMLQGGPHNHTIAGIASALLHAGTPEFAEYTRRVVENSRELCSRLQSLGLDILTGGTDN 337
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
H+ LVDLR G+ GA E + + ++ N+N + G+ S L+PSGIR+GT A+T RG
Sbjct: 338 HMLLVDLRSTGVDGAAVEHMCDALGISLNRNAIVGNSSPLSPSGIRVGTYAVTARGFGPE 397
Query: 542 DIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEE 649
++ +V D I +K+ E+ + D ++ +
Sbjct: 398 EMREVGDIIGGVVKLCREMTGGRKMSKADLHRVTSD 433
>UniRef50_Q23KJ4 Cluster: Serine hydroxymethyltransferase family
protein; n=1; Tetrahymena thermophila SB210|Rep: Serine
hydroxymethyltransferase family protein - Tetrahymena
thermophila SB210
Length = 515
Score = 169 bits (410), Expect = 7e-41
Identities = 78/191 (40%), Positives = 111/191 (58%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VA ++P PF+Y DIVT+ THK+LRGPR ++F+++GV+ V G ++ YD ++KI A+
Sbjct: 271 VATKILPDPFKYADIVTSATHKSLRGPRGALVFYKQGVKGVDKKGNEIKYDFKNKIENAI 330
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG QGGPHNH F EYQ+QV+KNAQ L + + Y+I T GT+
Sbjct: 331 FPGSQGGPHNHTIAGIAVALKEAQQQNFKEYQQQVVKNAQALFQSFSQKQYNILTNGTEN 390
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
HL LVD + G+ +LE + ++T+P S + LGT +TTRG E
Sbjct: 391 HLVLVDFKSKGINTLQLIHLLEQVHIDTYRSTLPNGKETFISSFLALGTHPMTTRGCTEN 450
Query: 542 DIDKVVDFIDR 574
D + +FIDR
Sbjct: 451 DFKTIAEFIDR 461
>UniRef50_Q5C0V4 Cluster: SJCHGC07535 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC07535 protein - Schistosoma
japonicum (Blood fluke)
Length = 218
Score = 165 bits (400), Expect = 1e-39
Identities = 77/170 (45%), Positives = 110/170 (64%), Gaps = 1/170 (0%)
Frame = +2
Query: 152 DLESKINQAVFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRG 331
D E +IN+AVFPGLQGGPHN+ E+ YQ+QV+KN ++LC+ L G
Sbjct: 23 DFERRINEAVFPGLQGGPHNNTIAAMAVCLKEAASPEYRVYQEQVLKNMKQLCKSLTDYG 82
Query: 332 YSIATGGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTP 511
Y + TGG+D HL L+DLR + + GA AE++LEL +A NKNT PGD+SAL P G+R G+
Sbjct: 83 YELVTGGSDTHLCLIDLRPLKIDGARAEKILELVRIAANKNTCPGDLSALRPGGLRFGSA 142
Query: 512 ALTTRGLKEADIDKVVDFIDRALKIGLEIIKVSGLKLV-DFNKAIEENAE 658
ALT+R +E D KV +FI ++I ++ +++ KL+ D+ +E N E
Sbjct: 143 ALTSRNFREKDFIKVAEFIHTGIQIAVKANELANSKLLKDYEVVVETNVE 192
>UniRef50_A6PKY7 Cluster: Serine hydroxymethyltransferase; n=2;
Bacteria|Rep: Serine hydroxymethyltransferase -
Victivallis vadensis ATCC BAA-548
Length = 572
Score = 159 bits (385), Expect = 7e-38
Identities = 86/196 (43%), Positives = 111/196 (56%), Gaps = 1/196 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VAAG P+P YCD+VTTTTHKTLRGPR G+I ++ + IN V
Sbjct: 365 VAAGEHPNPVPYCDVVTTTTHKTLRGPRGGLILCKE--------------EYLKSINSKV 410
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG+QGGP H F YQ QV NA +L E L+ RG+ I +GGTD
Sbjct: 411 FPGMQGGPLEHVIAAKAICFGEALTPAFKAYQHQVKLNAAKLAEELVKRGFRIVSGGTDN 470
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGD-ISALNPSGIRLGTPALTTRGLKE 538
HL L+DLR G L++ + NKN +P D SGIR+GTPA+TTRGLKE
Sbjct: 471 HLMLIDLRPKHATGKAVANALDIAHITANKNMIPFDPEKPFVTSGIRVGTPAITTRGLKE 530
Query: 539 ADIDKVVDFIDRALKI 586
A++ +V DFI+R +++
Sbjct: 531 AEMVRVADFIERGVEL 546
>UniRef50_Q72IH2 Cluster: Serine hydroxymethyltransferase; n=6;
Bacteria|Rep: Serine hydroxymethyltransferase - Thermus
thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Length = 407
Score = 159 bits (385), Expect = 7e-38
Identities = 89/197 (45%), Positives = 113/197 (57%), Gaps = 1/197 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VAAG+ P+P Y +VT+TTHKTLRGPR G+I +N +L +I++ +
Sbjct: 205 VAAGLHPNPLPYAHVVTSTTHKTLRGPRGGLIL---------SNDP----ELGKRIDKLI 251
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG+QGGP H EF EY + V++NA+RL E L RGY I TGGTD
Sbjct: 252 FPGIQGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEALARRGYRIVTGGTDN 311
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALN-PSGIRLGTPALTTRGLKE 538
HL LVDLR GL G AE L+ + NKN +P D SGIR+GTPA+TTRG
Sbjct: 312 HLFLVDLRPKGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIGTPAITTRGFTP 371
Query: 539 ADIDKVVDFIDRALKIG 589
++ V + IDRAL G
Sbjct: 372 EEMPLVAELIDRALLEG 388
>UniRef50_Q9A8J6 Cluster: Serine hydroxymethyltransferase; n=42;
Bacteria|Rep: Serine hydroxymethyltransferase -
Caulobacter crescentus (Caulobacter vibrioides)
Length = 429
Score = 154 bits (373), Expect = 2e-36
Identities = 87/200 (43%), Positives = 111/200 (55%), Gaps = 1/200 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+A G +P + IVTTTTHKTLRGPR G++ N + ++ K+N AV
Sbjct: 216 IAGGAYANPIPHAHIVTTTTHKTLRGPRGGLVL---------TNDEAII----KKVNSAV 262
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPGLQGGP H F +Y +QV+ NA+ L E L+ G +I +GGTD
Sbjct: 263 FPGLQGGPLEHVIAAKAVAFGEALQPSFKDYARQVVANARALAEALLKSGVNIVSGGTDS 322
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALN-PSGIRLGTPALTTRGLKE 538
HL LVDLR G+ G AE LE + CNKN VP D + SGIRLGTPA TTRG KE
Sbjct: 323 HLMLVDLRPKGVTGRDAEHSLERAYMTCNKNGVPFDTAPFTITSGIRLGTPAGTTRGFKE 382
Query: 539 ADIDKVVDFIDRALKIGLEI 598
A+ +V + I + GL +
Sbjct: 383 AEFTRVGELIGEVVN-GLAV 401
>UniRef50_Q8KC36 Cluster: Serine hydroxymethyltransferase; n=103;
cellular organisms|Rep: Serine hydroxymethyltransferase
- Chlorobium tepidum
Length = 440
Score = 152 bits (369), Expect = 6e-36
Identities = 84/200 (42%), Positives = 111/200 (55%), Gaps = 7/200 (3%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRK------GVRSVKANGQKVMYDLES 163
VAAG+ +P +C VTTTTHKTLRGPR G+I K G+ NG +V +
Sbjct: 207 VAAGLSANPMPHCHFVTTTTHKTLRGPRGGMIMMGKDFENPLGLTINTKNGSRVKM-MSE 265
Query: 164 KINQAVFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIA 343
I+ V PG+QGGP H EF Y +Q+ NA + ++ GY I
Sbjct: 266 VIDAEVMPGIQGGPLMHIIAGKAVAFGEALQPEFKAYAQQIKDNAAAMAAKFLAAGYHIV 325
Query: 344 TGGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVP-GDISALNPSGIRLGTPALT 520
+GGT HL L+DLR + G AE +L + NKN VP D S SGIR+GTPA+T
Sbjct: 326 SGGTKNHLMLLDLRNKNVNGKVAENLLHEAGITVNKNMVPFDDKSPFVTSGIRIGTPAMT 385
Query: 521 TRGLKEADIDKVVDFIDRAL 580
TRG+K A+ +K+V+FIDR +
Sbjct: 386 TRGMKVAEAEKIVEFIDRVI 405
>UniRef50_Q9RYB2 Cluster: Serine hydroxymethyltransferase; n=43;
Bacteria|Rep: Serine hydroxymethyltransferase -
Deinococcus radiodurans
Length = 408
Score = 150 bits (363), Expect = 3e-35
Identities = 83/195 (42%), Positives = 112/195 (57%), Gaps = 1/195 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+AAG P+ + +V +TTHKTLRGPR G+I AN ++ L+ + V
Sbjct: 209 IAAGEHPNALPHAHVVASTTHKTLRGPRGGIIL---------ANDPEIAKQLD----RTV 255
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG QGGP H EF +Y +Q+IKNAQ L +GY + +GGTD
Sbjct: 256 FPGYQGGPLEHVIAAKAVAFGEALRPEFKDYARQIIKNAQALAGEFQQKGYRVVSGGTDN 315
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGLKE 538
HL L+DLR GL G A R+L+ + +K+T+P D L+ GIR+GTPA+TTRG+ E
Sbjct: 316 HLFLLDLRPQGLNGTKATRLLDANHITISKSTLPYDTEKILHGGGIRIGTPAVTTRGMTE 375
Query: 539 ADIDKVVDFIDRALK 583
A + +V D IDRALK
Sbjct: 376 AHMTQVADLIDRALK 390
>UniRef50_Q6LHN7 Cluster: Serine hydroxymethyltransferase 2; n=27;
Bacteria|Rep: Serine hydroxymethyltransferase 2 -
Photobacterium profundum (Photobacterium sp. (strain
SS9))
Length = 431
Score = 149 bits (362), Expect = 4e-35
Identities = 86/194 (44%), Positives = 106/194 (54%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+AAG PSP + ++TTTTHKTLRGPR G+I + D+ KIN AV
Sbjct: 219 IAAGEHPSPIPHAHVITTTTHKTLRGPRGGMILTN-------------LEDINKKINSAV 265
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPGLQGGP H +F Y K VI NA+ L E L +RG I T GTD
Sbjct: 266 FPGLQGGPLMHVIAGKAVAFGEALEPDFKIYIKNVISNAKVLAEVLQNRGCDIVTNGTDT 325
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGLKE 538
HL LVDLR GL+G AE LE + CNKN +P D + SGIRLGTPA T+RG
Sbjct: 326 HLMLVDLRPKGLKGNAAENALERAGITCNKNGIPFDTEKPMVTSGIRLGTPAGTSRGFGN 385
Query: 539 ADIDKVVDFIDRAL 580
+ ++ ++I L
Sbjct: 386 DEFKQIGEWIGDVL 399
>UniRef50_Q11NZ7 Cluster: Serine hydroxymethyltransferase; n=6;
Bacteria|Rep: Serine hydroxymethyltransferase -
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Length = 431
Score = 148 bits (358), Expect = 1e-34
Identities = 80/198 (40%), Positives = 112/198 (56%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRS---VKA-NGQKVMYDLESKI 169
+A G++ P +C IV+TTTHKTLRGPR GVI K + +K G+ M + + +
Sbjct: 209 IAKGLLNDPIPHCHIVSTTTHKTLRGPRGGVIMMGKDFENPFGLKTPKGETRM--MSNVL 266
Query: 170 NQAVFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATG 349
+ VFPG QGGP H ++++Y KQ+ KNAQ + E + +GY I +G
Sbjct: 267 DMGVFPGTQGGPLEHVIAAKAVAFQEALSTDYLQYAKQIQKNAQIMAEAFLKKGYDIISG 326
Query: 350 GTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVP-GDISALNPSGIRLGTPALTTR 526
GTD HL L+DLR L G AE L + NKN VP D S SG+R+GT A+T+R
Sbjct: 327 GTDNHLMLIDLRSKNLTGKEAENALIRADITINKNMVPFDDKSPFVTSGMRVGTAAITSR 386
Query: 527 GLKEADIDKVVDFIDRAL 580
G+ D+ ++V+ ID L
Sbjct: 387 GMVGDDMIRIVEMIDTVL 404
>UniRef50_Q98A81 Cluster: Serine hydroxymethyltransferase 2; n=4;
Bacteria|Rep: Serine hydroxymethyltransferase 2 -
Rhizobium loti (Mesorhizobium loti)
Length = 437
Score = 144 bits (350), Expect = 1e-33
Identities = 78/192 (40%), Positives = 112/192 (58%), Gaps = 2/192 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+ AG P+P +CD+VT+T+HK++RGPR G I + R ++L +I++AV
Sbjct: 213 IVAGAHPNPVVHCDVVTSTSHKSIRGPRGGFILSKNEDRYQALYHSTSKHNLAKRIDRAV 272
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FP LQGGPH + F Y Q++KNA+ L E L+ RGY + TGGTD
Sbjct: 273 FPQLQGGPHMNTIAALAVALQEAATPSFRTYGHQIVKNAKALAEALLGRGYYLVTGGTDN 332
Query: 362 HLALVDLRGVGLRG-APAERVLELCSVACNKNTVPGD-ISALNPSGIRLGTPALTTRGLK 535
H+ ++DLR L G A AER L + N + VPGD SGIRLG+PA+T+ G++
Sbjct: 333 HMLILDLRDRPLSGKAYAER-LARAGIITNFDMVPGDPRDPTVTSGIRLGSPAVTSMGMR 391
Query: 536 EADIDKVVDFID 571
EA++ ++ FID
Sbjct: 392 EAEMVQIAAFID 403
>UniRef50_Q6G3L3 Cluster: Serine hydroxymethyltransferase; n=163;
cellular organisms|Rep: Serine hydroxymethyltransferase
- Bartonella henselae (Rochalimaea henselae)
Length = 437
Score = 142 bits (343), Expect = 9e-33
Identities = 82/194 (42%), Positives = 103/194 (53%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VA GV PSP + IVTTTTHK+LRGPR G+I + L KIN A+
Sbjct: 218 VAGGVHPSPVPHAHIVTTTTHKSLRGPRGGLILTNDEI-------------LAKKINSAI 264
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPGLQGGP H F +Y V+ NA+ L + L S G+ I +GGTD
Sbjct: 265 FPGLQGGPLMHVIAAKAVAFEEALQPVFKDYSANVVANAKTLAKTLQSNGFDIVSGGTDN 324
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGLKE 538
HL LVDLR + G AE L + CNKN++P D+ + SGIRLG+PA TTRG E
Sbjct: 325 HLLLVDLRSKKVTGKCAELALGRAHITCNKNSIPFDLETPFITSGIRLGSPAATTRGFAE 384
Query: 539 ADIDKVVDFIDRAL 580
+ ++ I L
Sbjct: 385 NEFIEIAHMISEIL 398
>UniRef50_Q62I16 Cluster: Serine hydroxymethyltransferase 1; n=454;
root|Rep: Serine hydroxymethyltransferase 1 -
Burkholderia mallei (Pseudomonas mallei)
Length = 415
Score = 141 bits (342), Expect = 1e-32
Identities = 78/195 (40%), Positives = 107/195 (54%), Gaps = 1/195 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+AAGV P+P + D VTTTTHK+LRGPR GVI + + E +IN A+
Sbjct: 209 IAAGVYPNPVPHADFVTTTTHKSLRGPRGGVILMKA--------------EYEKQINSAI 254
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG+QGGP H EF EYQ++V++NA+ L + L+ RG I +G T+
Sbjct: 255 FPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTLVKRGLRIVSGRTES 314
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGD-ISALNPSGIRLGTPALTTRGLKE 538
H+ LVDLR + G AE L + NKN +P D SG+RLG+PA+TTRG
Sbjct: 315 HVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGP 374
Query: 539 ADIDKVVDFIDRALK 583
+ + V + I L+
Sbjct: 375 QEAELVGNLIADVLE 389
>UniRef50_Q89HS7 Cluster: Serine hydroxymethyltransferase; n=2;
Rhizobiales|Rep: Serine hydroxymethyltransferase -
Bradyrhizobium japonicum
Length = 460
Score = 139 bits (337), Expect = 5e-32
Identities = 83/209 (39%), Positives = 118/209 (56%), Gaps = 3/209 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEY-CDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
VAA V+ +P + D++TTT+HKTLRGPR G+I RK + +I+ +
Sbjct: 241 VAANVMRNPLDAGFDVMTTTSHKTLRGPRGGIILCRK--------------ENAGRIDAS 286
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTD 358
VFPGLQGGPH + +F Y +QV++NA+ L L+ RG + T GTD
Sbjct: 287 VFPGLQGGPHMNVVAGIAVTLKKAATSDFQVYARQVLRNAKVLAGALMERGMKLVTDGTD 346
Query: 359 VHLALVDLRG-VGLRGAPAERVLELCSVACNKNTVPGDISA-LNPSGIRLGTPALTTRGL 532
H+ +VD VGL G AE VL+ ++ NK +P D L PSGIRLGTPA TTRG+
Sbjct: 347 NHMMVVDTAASVGLDGRAAEDVLDAIAITTNKQVIPDDPRPPLRPSGIRLGTPAATTRGM 406
Query: 533 KEADIDKVVDFIDRALKIGLEIIKVSGLK 619
E ++ ++ +FI AL+ + V+ L+
Sbjct: 407 GEPEMRRIGEFIAAALQANGNDVVVARLR 435
>UniRef50_Q5CM80 Cluster: Serine hydroxymethyltransferase; n=2;
Cryptosporidium|Rep: Serine hydroxymethyltransferase -
Cryptosporidium hominis
Length = 445
Score = 134 bits (324), Expect = 2e-30
Identities = 76/210 (36%), Positives = 115/210 (54%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
V AG PSP +Y D +TTT+HKTLRGPR+ +IF+RK V S + KI+++V
Sbjct: 214 VVAGKYPSPKDYADFITTTSHKTLRGPRSAIIFYRKEVES----------KIRVKIDESV 263
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
+Q H + +V+Y +V++++Q LC+ L G I T GTD
Sbjct: 264 SKEIQSSIHFNQVAALCFQLKQVVSASWVKYASRVLESSQLLCKLLEESGIKILTNGTDS 323
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
H L+D R + + GA AE+ LE+C ++ +++++P D +N SG+RLGT AL +RG++
Sbjct: 324 HKILIDTRSLNISGAKAEKALEVCEISTSRSSLPCDGRTMNCSGVRLGTAALASRGMELD 383
Query: 542 DIDKVVDFIDRALKIGLEIIKVSGLKLVDF 631
D V I L +I K G L +F
Sbjct: 384 DFKFVSRIIVEVLTTARDIQK-DGETLAEF 412
>UniRef50_UPI0000E49DF3 Cluster: PREDICTED: similar to serine
hydroxymethyltransferase isoform 1; n=4; Coelomata|Rep:
PREDICTED: similar to serine hydroxymethyltransferase
isoform 1 - Strongylocentrotus purpuratus
Length = 496
Score = 134 bits (323), Expect = 2e-30
Identities = 68/135 (50%), Positives = 87/135 (64%), Gaps = 1/135 (0%)
Frame = +2
Query: 260 EFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDVHLALVDLRGVGLRGAPAERVLELCSV 439
EF Y + V+ NAQ + E L+ RGY+I++GGTD HL L+DLR +GL GA E VLE +
Sbjct: 336 EFKLYARDVVTNAQAMAEELMKRGYTISSGGTDTHLLLLDLRPLGLDGARGEFVLERVGI 395
Query: 440 ACNKNTVPGDISALNPSGIRLGTPALTTRGLKEADIDKVVDFIDRALKIGLEI-IKVSGL 616
NKNT PGD SAL P G+R+GTPALT+R K D VVD+IDR LK+ E K S
Sbjct: 396 VLNKNTCPGDKSALKPGGLRIGTPALTSRNFKVTDFMMVVDYIDRGLKLTAEANKKCSST 455
Query: 617 KLVDFNKAIEENAEF 661
L DF + +++F
Sbjct: 456 TLRDFKAYVTSDSDF 470
Score = 75.4 bits (177), Expect = 1e-12
Identities = 31/38 (81%), Positives = 37/38 (97%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGV 115
VAAGV+ +PFEYCDIVT+TTHKTLRGPR+G+IFFR+GV
Sbjct: 288 VAAGVVANPFEYCDIVTSTTHKTLRGPRSGIIFFRRGV 325
>UniRef50_Q8FQR1 Cluster: Serine hydroxymethyltransferase; n=37;
Bacteria|Rep: Serine hydroxymethyltransferase -
Corynebacterium efficiens
Length = 434
Score = 128 bits (309), Expect = 1e-28
Identities = 79/202 (39%), Positives = 103/202 (50%), Gaps = 6/202 (2%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VAAG+ PSP Y D+V++T HKTL GPR+G+I ++ D K+N +V
Sbjct: 216 VAAGLHPSPVPYADVVSSTVHKTLGGPRSGIILAKQ--------------DYAKKLNSSV 261
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLI-----SRGYSIAT 346
FPG QGGP H +F E Q + I+ A+ L E L + G + T
Sbjct: 262 FPGQQGGPLMHAIAAKATALKIAGTDQFAERQARTIEGARILAERLTASDAKAAGIDVLT 321
Query: 347 GGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGD-ISALNPSGIRLGTPALTT 523
GGTDVHL L DLR + G AE +L + N+N VP D + SG+R+GTPAL T
Sbjct: 322 GGTDVHLVLADLRNSEMDGQQAEDLLHEVGITVNRNAVPFDPRPPMVTSGLRIGTPALAT 381
Query: 524 RGLKEADIDKVVDFIDRALKIG 589
RG +V D I AL G
Sbjct: 382 RGFDATAFTEVADIIGTALAQG 403
>UniRef50_Q8EWD1 Cluster: Serine hydroxymethyltransferase; n=14;
cellular organisms|Rep: Serine hydroxymethyltransferase
- Mycoplasma penetrans
Length = 412
Score = 126 bits (305), Expect = 4e-28
Identities = 78/187 (41%), Positives = 99/187 (52%), Gaps = 2/187 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+ AG P+P Y DIVTTTTHKTLRGPR+G+I N ++++ KIN AV
Sbjct: 200 IVAGYHPNPLPYADIVTTTTHKTLRGPRSGLIL---------TNNEELI----KKINSAV 246
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG QGGP H EF Y K VI N L + L GY I G+D
Sbjct: 247 FPGSQGGPLMHVIAAKYLCFDEASKPEFKTYIKNVIDNIAILSQTLKELGYKIIADGSDN 306
Query: 362 HLALVDL-RGVGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGLK 535
HL VDL + G E+ LE + NKN +P DI SA +PSGIR+G+ A+TTRG
Sbjct: 307 HLLSVDLYSSKQITGDLVEQWLEQAKIVVNKNLIPYDINSAKSPSGIRIGSAAMTTRGFT 366
Query: 536 EADIDKV 556
+ ++
Sbjct: 367 TKEFKQI 373
>UniRef50_Q9PJW0 Cluster: Serine hydroxymethyltransferase; n=8;
Chlamydiaceae|Rep: Serine hydroxymethyltransferase -
Chlamydia muridarum
Length = 497
Score = 125 bits (302), Expect = 8e-28
Identities = 75/198 (37%), Positives = 106/198 (53%), Gaps = 4/198 (2%)
Frame = +2
Query: 2 VAAGVI---PSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKIN 172
VA GV +P Y DIVTTTTHKTLRGPR G++ +K + +N
Sbjct: 265 VAGGVFIGEENPIPYADIVTTTTHKTLRGPRGGLVLAKK--------------EYSDTLN 310
Query: 173 QAVFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGG 352
+A P + GGP H F +Y QV++NA+ L E G + TGG
Sbjct: 311 KAC-PLMMGGPLPHVIAAKAVALKEAMTINFRKYAHQVVENARTLAEIFQRNGLRLLTGG 369
Query: 353 TDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISA-LNPSGIRLGTPALTTRG 529
TD H+ ++DL +G+ G AE +L +A N+N++P D S SGIRLGTPALTT G
Sbjct: 370 TDNHMLIIDLTSLGVPGRIAEDMLTSVGIAVNRNSIPSDASGQWKTSGIRLGTPALTTLG 429
Query: 530 LKEADIDKVVDFIDRALK 583
+ A++++V + I + L+
Sbjct: 430 MGSAEMEEVANIIAKVLR 447
>UniRef50_A7D249 Cluster: Glycine hydroxymethyltransferase; n=1;
Halorubrum lacusprofundi ATCC 49239|Rep: Glycine
hydroxymethyltransferase - Halorubrum lacusprofundi ATCC
49239
Length = 460
Score = 125 bits (301), Expect = 1e-27
Identities = 78/196 (39%), Positives = 101/196 (51%), Gaps = 3/196 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VAAGV PSP D VT +THKT+R R G++ + + I++AV
Sbjct: 252 VAAGVHPSPVGVADFVTGSTHKTIRAGRGGIVMCDE--------------EFADDIDKAV 297
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG QGGP H F EY + V+ NA+ L E L G+S+ +GGTD
Sbjct: 298 FPGGQGGPLMHNIAGKAVGFKEALDPSFDEYAQNVVDNAEVLAETLQDHGFSLVSGGTDN 357
Query: 362 HLALVDLRG--VGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGL 532
HL LVDLR L G A L ++ N NTVPG+ S NPSGIR+GT +TTRG
Sbjct: 358 HLVLVDLRDSHPDLPGGDAADALAAANIVLNGNTVPGETRSPFNPSGIRVGTAGVTTRGF 417
Query: 533 KEADIDKVVDFIDRAL 580
+++V D I R +
Sbjct: 418 DADVMEEVGDLIHRVV 433
>UniRef50_Q9HPY5 Cluster: Serine hydroxymethyltransferase; n=79;
cellular organisms|Rep: Serine hydroxymethyltransferase
- Halobacterium salinarium (Halobacterium halobium)
Length = 415
Score = 124 bits (298), Expect = 3e-27
Identities = 80/196 (40%), Positives = 100/196 (51%), Gaps = 3/196 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VAAG SP D VT +THKT+R R G++ + D++S AV
Sbjct: 207 VAAGEHASPVGVADFVTGSTHKTIRAGRGGIVMCDEAFAD----------DIDS----AV 252
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG QGGP H F EY QV++NA L E L G+S+ +GGTD
Sbjct: 253 FPGAQGGPLMHNIAGKAVGFNEALDPAFEEYAAQVVENAAVLGERLQEHGFSLVSGGTDT 312
Query: 362 HLALVDLR--GVGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGL 532
HL LVDLR + G E LE + N NTVP + SA +PSGIR+GTPALTTRG
Sbjct: 313 HLVLVDLRESHPDISGGDVEGELEDVGIVLNANTVPDETRSAFDPSGIRIGTPALTTRGF 372
Query: 533 KEADIDKVVDFIDRAL 580
++ V D I R +
Sbjct: 373 DADAMETVADCIARVI 388
>UniRef50_Q057P9 Cluster: Serine hydroxymethyltransferase; n=3;
Gammaproteobacteria|Rep: Serine hydroxymethyltransferase
- Buchnera aphidicola subsp. Cinara cedri
Length = 417
Score = 123 bits (297), Expect = 3e-27
Identities = 70/203 (34%), Positives = 109/203 (53%), Gaps = 1/203 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+ AG+ P+P +Y +V+TTTHKTL GPR G+I + G K +Y SK++ +V
Sbjct: 206 IVAGIYPNPLKYAHVVSTTTHKTLGGPRGGLI--------ISNCGNKKIY---SKLDSSV 254
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG QGGP H +F QK ++ ++++ + + R +S+ +G T+
Sbjct: 255 FPGSQGGPLMHVIAAKAISFKEALEPKFFLLQKNILFFSKKMVKIFLKRNFSVISGKTNN 314
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGLKE 538
HL L+DL + G A +L L + NKNT+P D S SGIR+GTPA+ RG+
Sbjct: 315 HLFLIDLSEKKISGKEASNILALARIIVNKNTIPNDSQSPYITSGIRIGTPAIVKRGISI 374
Query: 539 ADIDKVVDFIDRALKIGLEIIKV 607
+ K+ ++I L +IK+
Sbjct: 375 KYVIKITNWICDILNEPNNLIKI 397
>UniRef50_Q183S3 Cluster: Serine hydroxymethyltransferase; n=1;
Clostridium difficile 630|Rep: Serine
hydroxymethyltransferase - Clostridium difficile (strain
630)
Length = 418
Score = 121 bits (291), Expect = 2e-26
Identities = 70/192 (36%), Positives = 103/192 (53%), Gaps = 1/192 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VAA VIPSP Y D V+++T KT GPR+G++ KA K K+++ V
Sbjct: 206 VAAKVIPSPVPYADFVSSSTTKTFCGPRSGIVL-------CKAEHAK-------KLDKGV 251
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG G H + +F + +QV+ NAQ L LIS G+SI +GGTD
Sbjct: 252 FPGTLGSIHLNTVAAKAFSLLYLSTDKFKKIMEQVVVNAQTLASELISHGFSIVSGGTDN 311
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGD-ISALNPSGIRLGTPALTTRGLKE 538
H+ +VDLR L G E+ LE + NKN +P D S SG+R+G +++ RGLKE
Sbjct: 312 HIVMVDLRSKNLTGKQFEKALEYVGITVNKNVIPDDPQSPFVTSGVRIGLTSISQRGLKE 371
Query: 539 ADIDKVVDFIDR 574
++ ++ +++
Sbjct: 372 KEVIQIAGIMNK 383
>UniRef50_A0CF19 Cluster: Chromosome undetermined scaffold_174,
whole genome shotgun sequence; n=4; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_174,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 439
Score = 111 bits (268), Expect = 1e-23
Identities = 63/195 (32%), Positives = 99/195 (50%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
++AGVIPSPF Y DIV TTTHK+LRGPR +I++ K+ Y +++I+++V
Sbjct: 222 MSAGVIPSPFPYADIVMTTTHKSLRGPRGSLIYY------------KLQY--KNRIDESV 267
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
PGL G H H +++ QK V+ N + G+ + GGT+
Sbjct: 268 APGLVAGAHFHTITGIAVALKETQSPSYIQLQKDVVDNNKHFAAEFQRLGFDLIAGGTEN 327
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEA 541
HL LVDLR + E +L ++ CNK VP D + P +R+G+ L+ R +
Sbjct: 328 HLILVDLRKFNVDAVKMEYILSQINIQCNKQLVPFD-TVPQPRALRVGSIPLSVRQASKE 386
Query: 542 DIDKVVDFIDRALKI 586
+V I ++++
Sbjct: 387 HFTRVAQIIKESVEL 401
>UniRef50_Q05FV9 Cluster: Serine hydroxymethyltransferase; n=1;
Candidatus Carsonella ruddii PV|Rep: Serine
hydroxymethyltransferase - Carsonella ruddii (strain PV)
Length = 398
Score = 107 bits (257), Expect = 2e-22
Identities = 66/203 (32%), Positives = 105/203 (51%), Gaps = 1/203 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+A+G+ PSP Y +VTTTTHKTLRG + G+I K++ KIN +V
Sbjct: 199 IASGLYPSPLNYSSLVTTTTHKTLRGIKGGIIL---------TQNSKII----KKINLSV 245
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FPG QGG ++ F+ Y KQ+I N++ + + + RGY T+
Sbjct: 246 FPGQQGGCISNNVLGKLITFKEANNINFLNYTKQIIINSKIMLKTFLYRGYKTIDLKTEN 305
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDIS-ALNPSGIRLGTPALTTRGLKE 538
H+ ++ V E+ LE + N+N +P D + +LNPSGIR+GT +TTR +K+
Sbjct: 306 HMFIIK---VNNNSFYLEKKLEKYGILINRNFIPNDKNKSLNPSGIRIGTSCITTRKIKK 362
Query: 539 ADIDKVVDFIDRALKIGLEIIKV 607
+ + ++I ++ IIK+
Sbjct: 363 KGSELISNYICDLIEFNNNIIKI 385
>UniRef50_A6MJY3 Cluster: Mitochondrial serine
hydroxymethyltransferase-like protein; n=5;
Euteleostomi|Rep: Mitochondrial serine
hydroxymethyltransferase-like protein - Callithrix
jacchus (Common marmoset)
Length = 122
Score = 103 bits (247), Expect = 4e-21
Identities = 53/96 (55%), Positives = 66/96 (68%)
Frame = +2
Query: 371 LVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEADID 550
LVDLR GL GA AERVLEL S+ NKNT PGD SA+ P G+RLG PALT+R +E D
Sbjct: 1 LVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFR 60
Query: 551 KVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEENAE 658
+VVDFID + IGL+ +K KL DF + +++E
Sbjct: 61 RVVDFIDEGVNIGLD-VKSKTAKLQDFKSFLLKDSE 95
>UniRef50_O83349 Cluster: Serine hydroxymethyltransferase; n=18;
Bacteria|Rep: Serine hydroxymethyltransferase -
Treponema pallidum
Length = 574
Score = 103 bits (246), Expect = 5e-21
Identities = 70/197 (35%), Positives = 93/197 (47%), Gaps = 4/197 (2%)
Frame = +2
Query: 2 VAAGVIPS---PFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKIN 172
VA GV P + IVT+TTHKTLRGPR I +K G
Sbjct: 264 VAGGVFTGDEDPVRWSHIVTSTTHKTLRGPRGAFILCKKEFAEAVDKG------------ 311
Query: 173 QAVFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGG 352
P + GGP H F Y V NA+ L + I +G + TGG
Sbjct: 312 ---CPLVLGGPLPHVMAAKAVAFREARNAAFKTYAHAVRDNARALADACIQQGMQLQTGG 368
Query: 353 TDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDIS-ALNPSGIRLGTPALTTRG 529
TD HL L+D+R GL G AER L C V N+N++P D + A SG+R+GTPA+T+ G
Sbjct: 369 TDNHLLLLDVRPFGLTGRQAERALIDCGVTLNRNSLPFDPNGAWLTSGLRIGTPAVTSLG 428
Query: 530 LKEADIDKVVDFIDRAL 580
+ ++ ++ I R L
Sbjct: 429 MGPEEMKRIARLIARVL 445
>UniRef50_Q12RK5 Cluster: Glycine hydroxymethyltransferase; n=2;
Gammaproteobacteria|Rep: Glycine
hydroxymethyltransferase - Shewanella denitrificans
(strain OS217 / ATCC BAA-1090 / DSM 15013)
Length = 451
Score = 100 bits (239), Expect = 4e-20
Identities = 64/194 (32%), Positives = 89/194 (45%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
VA G PSP + TT THK L GPR G+I + + K + + Q+V
Sbjct: 222 VATGRHPSPINAAHVTTTCTHKQLAGPRGGLIMSGRDANEMVPGRNKT---FAASLEQSV 278
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
FP +QG P + EF Y +++ A + + Y + ++
Sbjct: 279 FPWMQGAPAVNIIAAKAAAFGYAMSPEFDAYMERIRTAADTVAMAFQQKDYEVVGRKSEN 338
Query: 362 HLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDI-SALNPSGIRLGTPALTTRGLKE 538
H L+ LRG L GA AE LE C + NKN VPG+ SA SG+R+GT +L R L
Sbjct: 339 HTVLIRLRG-DLTGAIAESALEKCGIIVNKNRVPGETRSAFVTSGLRIGTGSLAQRNLDP 397
Query: 539 ADIDKVVDFIDRAL 580
+VVD I + L
Sbjct: 398 EGCLRVVDLICKIL 411
>UniRef50_O29406 Cluster: Serine hydroxymethyltransferase; n=6;
Euryarchaeota|Rep: Serine hydroxymethyltransferase -
Archaeoglobus fulgidus
Length = 438
Score = 94.3 bits (224), Expect = 2e-18
Identities = 67/201 (33%), Positives = 99/201 (49%), Gaps = 7/201 (3%)
Frame = +2
Query: 2 VAAGVIPSPF-EYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+A +P E D++T +THKT GP+ +I RK +L K+++A
Sbjct: 217 IAGKAFQNPLKEGADVMTGSTHKTFFGPQRAIIASRK--------------ELAEKVDRA 262
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVE-YQKQVIKNAQRLCEGLISRGYSIA---T 346
VFPG+ ++H EF E Y KQV++NA+ L E L S GY +
Sbjct: 263 VFPGVVS--NHHLNTLAGYVVAAMEMLEFGEDYAKQVVRNAKALAEELYSLGYKVLGEKR 320
Query: 347 GGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDI--SALNPSGIRLGTPALT 520
G T+ H VD+R G G +VLE + NKN +P D NPSGIR+G +T
Sbjct: 321 GFTETHQVAVDVREFG-GGERVAKVLENAGIILNKNLLPWDSLEKTANPSGIRIGVQEVT 379
Query: 521 TRGLKEADIDKVVDFIDRALK 583
G+KE ++ + + +D A+K
Sbjct: 380 RIGMKEEEMRAIAEIMDAAIK 400
>UniRef50_Q8ZYF9 Cluster: Serine hydroxymethyltransferase; n=5;
Thermoproteaceae|Rep: Serine hydroxymethyltransferase -
Pyrobaculum aerophilum
Length = 430
Score = 87.0 bits (206), Expect = 4e-16
Identities = 68/220 (30%), Positives = 102/220 (46%), Gaps = 4/220 (1%)
Frame = +2
Query: 2 VAAGVIPSPF-EYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+ GV P+P E ++T++THKT GP+ G+I SV +L + I +A
Sbjct: 204 IIGGVFPNPLKEGAHVITSSTHKTFPGPQGGLI------ASVTDE------ELNNAIQRA 251
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIA---TG 349
VFP H H EY ++++NA+ L E L G + G
Sbjct: 252 VFPVFTSNYHLHRYAATYVTLIEMEHFG-AEYGARIVENAKALAEALAEEGVTPVGERLG 310
Query: 350 GTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRG 529
T H VD+ G G R+LE ++ NKN +P D S L PSGIR+G +T G
Sbjct: 311 YTKTHQVAVDVSKFG-GGDKVARLLEEANIIVNKNALPWDKSVLKPSGIRMGVQEMTRFG 369
Query: 530 LKEADIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEE 649
+ + ++ ++ FI R LK G + V ++V+F K E
Sbjct: 370 MGKGEMKEIAKFIARVLK-GEDPTAVK-REVVEFRKTFIE 407
>UniRef50_O23984 Cluster: Expressed sequence tag; n=7; Poaceae|Rep:
Expressed sequence tag - Hordeum vulgare (Barley)
Length = 111
Score = 83.0 bits (196), Expect = 6e-15
Identities = 37/82 (45%), Positives = 56/82 (68%)
Frame = +2
Query: 413 ERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEADIDKVVDFIDRALKIGL 592
E++ +LCS+ NKN V GD SAL+P G+R+G PA+T+RGL E D +++ +F+ +A+ I L
Sbjct: 2 EKMCDLCSITLNKNAVFGDSSALSPGGVRIGAPAMTSRGLVEKDFEQIAEFLHQAVTICL 61
Query: 593 EIIKVSGLKLVDFNKAIEENAE 658
I K G L DF+K + N +
Sbjct: 62 NIQKEHGKLLKDFSKGLVNNKD 83
>UniRef50_Q8TZ19 Cluster: Serine hydroxymethyltransferase; n=8;
Euryarchaeota|Rep: Serine hydroxymethyltransferase -
Methanopyrus kandleri
Length = 428
Score = 83.0 bits (196), Expect = 6e-15
Identities = 62/196 (31%), Positives = 94/196 (47%), Gaps = 7/196 (3%)
Frame = +2
Query: 2 VAAGVIPSPF-EYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+A G P E +VT +THKT GP+ G++ ++ DL I++A
Sbjct: 204 IAGGQFQDPIREGAHVVTGSTHKTFPGPQGGIVLCQR--------------DLADDIDEA 249
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVE-YQKQVIKNAQRLCEGLISRGYSIAT--- 346
VFPGL H H E+ E Y + ++NA+ L E L + G +
Sbjct: 250 VFPGLVSNHHLHHVAALAVALAEFK--EYGERYARDTVRNAKALAEALYAEGLRVLCEHR 307
Query: 347 GGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALN--PSGIRLGTPALT 520
G T+ H VD+R G AE+ LE ++ CNKN +P D + + PSGIRLGT LT
Sbjct: 308 GFTESHQIAVDVREQGGGAVIAEK-LESANILCNKNLLPWDDESKSHDPSGIRLGTQELT 366
Query: 521 TRGLKEADIDKVVDFI 568
G+ ++++ + + I
Sbjct: 367 RLGMGLSEMEYIAELI 382
>UniRef50_Q9YAH7 Cluster: Serine hydroxymethyltransferase; n=9;
Archaea|Rep: Serine hydroxymethyltransferase - Aeropyrum
pernix
Length = 439
Score = 82.2 bits (194), Expect = 1e-14
Identities = 59/199 (29%), Positives = 91/199 (45%), Gaps = 6/199 (3%)
Frame = +2
Query: 2 VAAGVIPSPFEY-CDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+ G P+P E D VT +THKT GP+ G +FFR L K+++
Sbjct: 211 IMGGAWPNPLERGADAVTGSTHKTFPGPQGGAVFFRD-------------EQLYKKVSKT 257
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIA---TG 349
+FP H H +Y QV NA++L E L + G + G
Sbjct: 258 IFPWWVSNHHLHRIPATAITAVEMKLYG-RDYASQVTSNARKLAEALAAEGLKVIGEHLG 316
Query: 350 GTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGD--ISALNPSGIRLGTPALTT 523
T H +VD+R +G GA +LE ++ NKN +P D + +PSGIR+G +T
Sbjct: 317 YTRSHQVVVDVRDLG-GGAKCASLLEESNIIVNKNLLPWDPPEAVKDPSGIRIGVQEVTR 375
Query: 524 RGLKEADIDKVVDFIDRAL 580
G+K +++++ I + L
Sbjct: 376 LGMKHGEMEEIAKLIRKVL 394
>UniRef50_Q5CM83 Cluster: Serine hydroxymethyltransferase 2; n=2;
Cryptosporidium|Rep: Serine hydroxymethyltransferase 2 -
Cryptosporidium hominis
Length = 438
Score = 79.4 bits (187), Expect = 7e-14
Identities = 54/197 (27%), Positives = 83/197 (42%)
Frame = +2
Query: 23 SPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAVFPGLQGG 202
+P+ YCDI+ + T +L GP+ G + K G L K+N AVFPGLQGG
Sbjct: 214 NPYRYCDIIYSNTQSSLGGPKGGFLMLNNS----KNPG------LFQKVNSAVFPGLQGG 263
Query: 203 PHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDVHLALVDL 382
PHNH E+ + N+ L + ++ G + GTD HL VD
Sbjct: 264 PHNHQIGSFAVQIQGMLTSRTSEFVAAALDNSAVLAQTMLDSGIPLLGDGTDTHLVSVDC 323
Query: 383 RGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKEADIDKVVD 562
+G+ ++L C + G+ N S + GT T R + + + +
Sbjct: 324 ERLGIPCELISKILTECKIRHTYRKF-GE----NRSSLMFGTLVYTFREGSVSQMAILGN 378
Query: 563 FIDRALKIGLEIIKVSG 613
I + +G+EI G
Sbjct: 379 LISDCINVGVEIFNKVG 395
>UniRef50_Q9HI38 Cluster: Serine hydroxymethyltransferase; n=5;
Thermoplasmatales|Rep: Serine hydroxymethyltransferase -
Thermoplasma acidophilum
Length = 426
Score = 77.8 bits (183), Expect = 2e-13
Identities = 62/200 (31%), Positives = 92/200 (46%), Gaps = 7/200 (3%)
Frame = +2
Query: 2 VAAGVIPSPF-EYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+A G P E DIVT +THKT GP+ GVI + KA + +A
Sbjct: 203 IAGGRFQDPLREGADIVTGSTHKTFPGPQHGVILGNTDDETWKA------------VRRA 250
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEF-VEYQKQVIKNAQRLCEGLISRGYSIAT--- 346
VFPG+ ++H EF Y +I NA+ L E L + G+++
Sbjct: 251 VFPGVLS--NHHLNAMAALGITAAEELEFGKRYADDIISNAKVLAEELYANGFNVLAEKR 308
Query: 347 GGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDIS--ALNPSGIRLGTPALT 520
G T+ H VD+ G G LE C + NKN +P D + + NPSGIR+G T
Sbjct: 309 GFTESHTMAVDVSKNG-GGKYVAETLEKCGIILNKNLLPWDDNKKSQNPSGIRIGVQEAT 367
Query: 521 TRGLKEADIDKVVDFIDRAL 580
G+ ++++ ++ I RA+
Sbjct: 368 RVGMGKSEMKEIASLITRAI 387
>UniRef50_Q883D8 Cluster: Serine hydroxymethyltransferase, putative;
n=1; Pseudomonas syringae pv. tomato|Rep: Serine
hydroxymethyltransferase, putative - Pseudomonas
syringae pv. tomato
Length = 364
Score = 76.2 bits (179), Expect = 7e-13
Identities = 56/196 (28%), Positives = 88/196 (44%), Gaps = 3/196 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+A G IP+P D+ T + KT+RG +I + KI++ V
Sbjct: 151 IACGAIPNPVPLADVATMSMDKTMRGAHGAIILCTAKIAQ--------------KIDKGV 196
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
PG Q EF EY +V+ NA L + + + TGGTD
Sbjct: 197 HPGTQSSFPISRLTQTAQALLHSQTAEFREYANRVLDNALLLEQHFLCIPNLLVTGGTDK 256
Query: 362 HLALVDLRGV-GLRGAPAERVLELCSVACNKNTVPGDISAL--NPSGIRLGTPALTTRGL 532
H +++ + G+ G AE+ LE SV ++ T+PGD ++ + GIRLGT +T+RG
Sbjct: 257 HYLVLNTKAAFGIDGVLAEQRLEAISVLSSRQTLPGDRTSRIDDAGGIRLGTAWITSRGY 316
Query: 533 KEADIDKVVDFIDRAL 580
+ ++ + I AL
Sbjct: 317 ELDEVSALATIIIEAL 332
>UniRef50_A6TST7 Cluster: Glycine hydroxymethyltransferase; n=1;
Alkaliphilus metalliredigens QYMF|Rep: Glycine
hydroxymethyltransferase - Alkaliphilus metalliredigens
QYMF
Length = 368
Score = 75.8 bits (178), Expect = 9e-13
Identities = 62/198 (31%), Positives = 95/198 (47%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 VAAGVIPSPFEY-CDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+A+G+ P+P E DI+ +THK+ GP+ G + + DL K+
Sbjct: 167 IASGMFPNPLEEGADIMFGSTHKSFPGPQGGFVVSNRE-------------DLIKKVGNT 213
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEF-VEYQKQVIKNAQRLCEGLISRGYSI---AT 346
+ P L +H EF EY KQV+ N++ L + L G+++ A
Sbjct: 214 LAPSLVTS--HHLNRLPALAASILEMKEFGEEYGKQVVNNSKALAKALNESGFNVLGKAK 271
Query: 347 GGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTR 526
G TD HL LVD+ G + AP + LE + C+ D S +P IR+GTP T R
Sbjct: 272 GYTDSHLLLVDV-GAYVDVAPGKE-LEKARILCSD-----DFSGNSPE-IRVGTPEATRR 323
Query: 527 GLKEADIDKVVDFIDRAL 580
G+KE ++ ++ +F RAL
Sbjct: 324 GMKEEEMKQIAEFFKRAL 341
>UniRef50_A0RYP2 Cluster: Glycine/serine hydroxymethyltransferase;
n=2; Thermoprotei|Rep: Glycine/serine
hydroxymethyltransferase - Cenarchaeum symbiosum
Length = 441
Score = 72.1 bits (169), Expect = 1e-11
Identities = 61/202 (30%), Positives = 93/202 (46%), Gaps = 9/202 (4%)
Frame = +2
Query: 2 VAAGVIPSPF-EYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+A G P E D +T +THKTL GP+ G++ R+ A G I +A
Sbjct: 217 IAGGQFQDPIREGADTMTMSTHKTLFGPQGGLVL----GRNEHAEG----------IKKA 262
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEF-VEYQKQVIKNAQRLCEGLISRGYSI--ATG 349
+FPGL H H EF +Y K V++NA+ L E L G+ + G
Sbjct: 263 MFPGLTSSHHIH--HMAAKAVAFTEALEFGKKYAKDVVRNAKALAESLSGLGFKVLGEDG 320
Query: 350 G-TDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISA----LNPSGIRLGTPA 514
G T H V++ G E LE ++ N+ +PGDI A L+P GIRLG
Sbjct: 321 GFTKSHQVAVNVLEYS-DGGKIEARLEKANIIVNRQLIPGDIKAGRHYLHPGGIRLGVSE 379
Query: 515 LTTRGLKEADIDKVVDFIDRAL 580
+T G+ ++ ++ + + +A+
Sbjct: 380 VTRLGMGTGEMAEIAELMKQAV 401
>UniRef50_A0GN01 Cluster: Glycine hydroxymethyltransferase; n=1;
Burkholderia phytofirmans PsJN|Rep: Glycine
hydroxymethyltransferase - Burkholderia phytofirmans
PsJN
Length = 358
Score = 68.1 bits (159), Expect = 2e-10
Identities = 59/199 (29%), Positives = 90/199 (45%), Gaps = 6/199 (3%)
Frame = +2
Query: 2 VAAGVIPSPF-EYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
++AG+ P E D++T ++ KT GP+ G+I + N + L I +
Sbjct: 142 ISAGLFQDPLGEGADVMTGSSGKTFSGPQGGIICW---------NTDR----LADTIAET 188
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIA---TG 349
+FP L G H Y +QV+ NAQ L E L RG ++ G
Sbjct: 189 IFPVLTGS-HQINRVAALAVAASEMLEYGPVYMRQVVANAQALAEFLHDRGINVLYAERG 247
Query: 350 GTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALN--PSGIRLGTPALTT 523
T H +VD R G G A R LE ++ CN+ +P D +GIRLGT +T
Sbjct: 248 YTQTHQIVVDSRPAG-SGRTAVRRLEAANIICNEMPLPWDSVETGGVETGIRLGTVEVTR 306
Query: 524 RGLKEADIDKVVDFIDRAL 580
RG+ A+++ + + I + L
Sbjct: 307 RGMGVAEMEWIAERIAKVL 325
>UniRef50_Q2GRC5 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 176
Score = 67.7 bits (158), Expect = 2e-10
Identities = 36/105 (34%), Positives = 59/105 (56%), Gaps = 1/105 (0%)
Frame = +2
Query: 275 QKQVIKNAQRLCEGLISRGYSIATGGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKN 454
Q+ + A L L+S+GY + TGGTD H+ L+D R + G E VL ++ N+N
Sbjct: 17 QQLYLDTAATLSRELLSKGYHLLTGGTDSHIMLLDHRKDRISGFEVESVLRQVNIIANQN 76
Query: 455 TVPGDISALNPSGIRLGTPALTTRGLKEA-DIDKVVDFIDRALKI 586
+PGD L SG+RL T + RGL+++ +V + + R +++
Sbjct: 77 PLPGD-KGLRFSGLRLATTPMVIRGLQDSKGFVQVAELVHRGIEL 120
>UniRef50_Q7XZ78 Cluster: Hydromethyl transferase; n=1; Griffithsia
japonica|Rep: Hydromethyl transferase - Griffithsia
japonica (Red alga)
Length = 100
Score = 61.7 bits (143), Expect = 2e-08
Identities = 28/68 (41%), Positives = 43/68 (63%), Gaps = 2/68 (2%)
Frame = +2
Query: 458 VPGDISALNPSGIRLGTPALTTRGLKEADIDKVVDFIDRALKIGLEIIK--VSGLKLVDF 631
VPGD+SA NP GIR+GT A+TTRG + D + +++DR + I ++ G K+V F
Sbjct: 1 VPGDVSAFNPGGIRMGTHAMTTRGCESGDFKAIAEYLDRGIAIASKVKADLGPGSKIVAF 60
Query: 632 NKAIEENA 655
+A++ A
Sbjct: 61 REALDSGA 68
>UniRef50_Q8IKR8 Cluster: Putative uncharacterized protein; n=1;
Plasmodium falciparum 3D7|Rep: Putative uncharacterized
protein - Plasmodium falciparum (isolate 3D7)
Length = 462
Score = 61.7 bits (143), Expect = 2e-08
Identities = 58/222 (26%), Positives = 97/222 (43%), Gaps = 4/222 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
++ +I SPF + DIV T ++ R + VIF++KG + V +G + YD E K+ A
Sbjct: 228 ISQNLINSPFTHSDIVFTYFNENFRAHNSFVIFYKKGYKCVNTDGHIIEYDYEKKLKYA- 286
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
F + N+ EF EY KQ+ +N L + I+R Y
Sbjct: 287 FDDIY---LNNIFFSFFTSFKLMKNEEFKEYVKQIKENTYILYK-YINRKY--------F 334
Query: 362 HLALVDLRG-VGLRGAPAERVLELCSVACNKNTVPGDI---SALNPSGIRLGTPALTTRG 529
H+ L + ++ + CNK + DI + N +GT LT+ G
Sbjct: 335 HIQYSQNNSFFNLNPSSCTFNIQEFYLLCNKLNIYFDILKDKSSNQKSFNIGTNNLTSLG 394
Query: 530 LKEADIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEENA 655
L DI V +F + ++ + + + S L + F + IE+N+
Sbjct: 395 LLTHDIKNVAEFFNESVVLYFYLKEKSKLTNMSFIQYIEDNS 436
>UniRef50_A5K3J5 Cluster: Serine hydroxymethyltransferase, putative;
n=1; Plasmodium vivax|Rep: Serine
hydroxymethyltransferase, putative - Plasmodium vivax
Length = 470
Score = 56.0 bits (129), Expect = 8e-07
Identities = 54/204 (26%), Positives = 85/204 (41%), Gaps = 7/204 (3%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
++ IPSPF + D+V T ++ +R VIF+++G + V G+ + Y+ E K+
Sbjct: 237 ISQDFIPSPFNHSDVVYTYFNENMRAHNCHVIFYKRGYKQVDKEGKLIHYEYEKKLKNQF 296
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSI--ATGGT 355
P N+ EF EY Q +N + L L ++I A G
Sbjct: 297 LPIRV----NNTIFSFLTSFKMMKNAEFKEYVIQSKENTRALLSHLNKNFFNIQYAQNGN 352
Query: 356 DVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNP-----SGIRLGTPALT 520
++L P V E C + + DI LNP +G LT
Sbjct: 353 FLNLNCT---------VPPFNVYEFHEF-CKQLNIFFDI--LNPFKYTQKSFNVGANYLT 400
Query: 521 TRGLKEADIDKVVDFIDRALKIGL 592
+ GL E D+ V +F++RAL + L
Sbjct: 401 SMGLLEGDMKTVAEFLNRALSLYL 424
>UniRef50_Q7RRP9 Cluster: Serine hydroxymethyltransferase,
mitochondrial; n=4; Plasmodium (Vinckeia)|Rep: Serine
hydroxymethyltransferase, mitochondrial - Plasmodium
yoelii yoelii
Length = 484
Score = 51.2 bits (117), Expect = 2e-05
Identities = 52/224 (23%), Positives = 93/224 (41%), Gaps = 7/224 (3%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQAV 181
+ I SPF DIV + ++ +R +IF+RKG +++ G+ + Y+ E + +
Sbjct: 251 IIGNFISSPFSQADIVFSYLNENIRANNCYIIFYRKGFKNISTQGKLICYEYEDNLKKTY 310
Query: 182 FPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTDV 361
F N+ EF EY Q+ KN L L + ++I
Sbjct: 311 FQ----NNVNNIICSLSTSFKCIQNCEFKEYIYQINKNINILFLYLNKKYFNI------- 359
Query: 362 HLALVDLRGVGLRGAPAERVLEL--CSVACNKNTVPGDISALNPS-----GIRLGTPALT 520
H D L A + + + + C K + DI +N S +GT LT
Sbjct: 360 HF---DQNNNFLNTACSNSLFNIQEYHIFCKKLNIFFDIININKSTYVQKSFNIGTNYLT 416
Query: 521 TRGLKEADIDKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIEEN 652
G++E D+ V +FI++++ + L + S + F + +E +
Sbjct: 417 ALGMEEHDMKYVSEFINQSILLYLYTKQKSANSNLTFLEYLESS 460
>UniRef50_Q0GPG8 Cluster: BZIP transcription factor bZIP94; n=1;
Glycine max|Rep: BZIP transcription factor bZIP94 -
Glycine max (Soybean)
Length = 230
Score = 48.8 bits (111), Expect = 1e-04
Identities = 19/26 (73%), Positives = 23/26 (88%)
Frame = +2
Query: 137 QKVMYDLESKINQAVFPGLQGGPHNH 214
Q+V+YD + KINQ VFPGLQGGP+NH
Sbjct: 157 QQVLYDYKDKINQPVFPGLQGGPYNH 182
>UniRef50_UPI00006DBC17 Cluster: hypothetical protein
BdolA_01004192; n=1; Burkholderia dolosa AUO158|Rep:
hypothetical protein BdolA_01004192 - Burkholderia
dolosa AUO158
Length = 122
Score = 45.6 bits (103), Expect = 0.001
Identities = 32/69 (46%), Positives = 35/69 (50%)
Frame = -1
Query: 210 LCGPPCRPGNTAWFIFDSKSYMTFCPFALTDLTPLRKNMTPARGPRSVL*VVVVTISQYS 31
+ GPPCRPGNTA IF FA++ K P RGPRSVL VV VT S
Sbjct: 23 ISGPPCRPGNTAELIF----------FAISSSLVSTK---PPRGPRSVLCVVDVTTCACS 69
Query: 30 NGLGITPAA 4
G PAA
Sbjct: 70 TGFAWRPAA 78
>UniRef50_A5P5T2 Cluster: Putative uncharacterized protein; n=3;
Methylobacterium|Rep: Putative uncharacterized protein -
Methylobacterium sp. 4-46
Length = 498
Score = 45.6 bits (103), Expect = 0.001
Identities = 44/133 (33%), Positives = 57/133 (42%)
Frame = -3
Query: 424 EHALGRRAPQPDAAQIHEREVHVGXXXXXXXXXXX*TLAQPLRVLYHLFLIFDEFSSCSL 245
E LGR A Q +H+ +V VG + Q L VL+HL + E L
Sbjct: 77 EGRLGRLAGQVLGPHVHQHQVVVGAAGGDVEAARDDRVGQRLGVLHHLLGVDLEVGRERL 136
Query: 244 FHGRGYGRYCVVVRSALQAREHSLVYLRFQIVHDLLSVRLDGPHALAEEYDTGTRTTQRL 65
G V R+AL+AREH R ++ L VR D HA A R QRL
Sbjct: 137 AEGHRLAGDDVHQRAALEAREHG----RVDLLGQSLVVRQD--HAAA-------RAAQRL 183
Query: 64 MSGGGHNIAVFER 26
+ G G ++ V ER
Sbjct: 184 VRGRGDDVGVRER 196
>UniRef50_Q3JGP6 Cluster: Putative uncharacterized protein; n=10;
Burkholderia|Rep: Putative uncharacterized protein -
Burkholderia pseudomallei (strain 1710b)
Length = 1031
Score = 37.1 bits (82), Expect = 0.38
Identities = 42/136 (30%), Positives = 56/136 (41%)
Frame = -3
Query: 427 LEHALGRRAPQPDAAQIHEREVHVGXXXXXXXXXXX*TLAQPLRVLYHLFLIFDEFSSCS 248
LE L RA Q AQI E+++ VG +A+ LRV H + E
Sbjct: 686 LERLLDLRALQALRAQIDEQQMVVGAARHEIDAARLQHVAERLRVREHAIDVGLEIVCQR 745
Query: 247 LFHGRGYGRYCVVVRSALQAREHSLVYLRFQIVHDLLSVRLDGPHALAEEYDTGTRTTQR 68
L V R+ALQA EH R ++ DLL V G H + R QR
Sbjct: 746 LAERHRLAGDHVHQRAALQAGEHR----RVDLLRDLLVV---GQH------EAAARAAQR 792
Query: 67 LMSGGGHNIAVFERAR 20
L+ ++ VF+R R
Sbjct: 793 LVRRRRDDVRVFDRVR 808
>UniRef50_Q0FXL6 Cluster: Serine hydroxymethyltransferase; n=1;
Fulvimarina pelagi HTCC2506|Rep: Serine
hydroxymethyltransferase - Fulvimarina pelagi HTCC2506
Length = 417
Score = 36.3 bits (80), Expect = 0.66
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Frame = +2
Query: 2 VAAGVIPSPFEY-CDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+A GV +P E D++TT+T+KTL GP ++ R + V+ + + +L + N A
Sbjct: 217 IAGGVFLNPLEVGVDLITTSTYKTLAGPTGAIVMGRDPEQGVRF-AEFLDANLLANQNAA 275
Query: 179 VFPGLQG 199
P L G
Sbjct: 276 RLPSLCG 282
>UniRef50_A0HCN5 Cluster: Putative uncharacterized protein; n=1;
Comamonas testosteroni KF-1|Rep: Putative
uncharacterized protein - Comamonas testosteroni KF-1
Length = 626
Score = 36.3 bits (80), Expect = 0.66
Identities = 44/178 (24%), Positives = 63/178 (35%), Gaps = 1/178 (0%)
Frame = -3
Query: 532 ETSCGQRWCTESDAAGVERXXXXXXXXXXXXXXA-ELEHALGRRAPQPDAAQIHEREVHV 356
ET+ G ++DAAG ER + + G A AQ+H+ V
Sbjct: 237 ETTGGHGGRADTDAAGHERLFGVIGDGVLVHGDVSQTQGRFGSLAGNALGAQVHQHHVAF 296
Query: 355 GXXXXXXXXXXX*TLAQPLRVLYHLFLIFDEFSSCSLFHGRGYGRYCVVVRSALQAREHS 176
G + L +L+ LFL+ E S G + +ALQA E
Sbjct: 297 GAAGDDAQTALGQRFGKHLGILHDLFLVGLELGSQGFLECHGLAGDDMHQGAALQAGEDG 356
Query: 175 LVYLRFQIVHDLLSVRLDGPHALAEEYDTGTRTTQRLMSGGGHNIAVFERARYYTCSN 2
V LL + L HA T TQ L+ GGG ++ + + C N
Sbjct: 357 -------AVDGLLVLGLHQDHA-------ATGATQALVGGGGDHVGMGHGVGVHACGN 400
>UniRef50_Q7UVI4 Cluster: Putative deoxyribonuclease yabD; n=3;
Planctomycetaceae|Rep: Putative deoxyribonuclease yabD -
Rhodopirellula baltica
Length = 277
Score = 35.1 bits (77), Expect = 1.5
Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
Frame = +2
Query: 470 ISALNPSGIRLGTPALTTRGLKEADI-DKVVDFIDRALKIGLEIIKVSGLKLVDFNKAIE 646
+SA +PS R+ T L D D V + +DRA + G+ I V G+ L +A+E
Sbjct: 10 VSAFDPSEPRMNPLFDTHAHLNSKDFNDNVAEVVDRARQAGVVGIGVIGIDLATSRRAVE 69
Query: 647 ENAEF 661
AEF
Sbjct: 70 LAAEF 74
>UniRef50_Q8GGQ5 Cluster: Serine hydroxymethyltransferase; n=1;
Streptomyces atroolivaceus|Rep: Serine
hydroxymethyltransferase - Streptomyces atroolivaceus
Length = 447
Score = 35.1 bits (77), Expect = 1.5
Identities = 26/107 (24%), Positives = 47/107 (43%), Gaps = 3/107 (2%)
Frame = +2
Query: 272 YQKQVIKNAQRLCEGLISRGYSIAT---GGTDVHLALVDLRGVGLRGAPAERVLELCSVA 442
Y + V+++ R L RG ++ G + H +D G+ AP + L + +
Sbjct: 285 YTRAVLEHTGRFGRLLTERGLTVVAADRGYSAGHQLWLDTEADGI--APKDAAARLSAAS 342
Query: 443 CNKNTVPGDISALNPSGIRLGTPALTTRGLKEADIDKVVDFIDRALK 583
N + G + G+R+G T +GL DID++ D A++
Sbjct: 343 LKVNFMAG-LPGFTGQGVRIGLNEATYQGLSGDDIDELADIFVAAVR 388
>UniRef50_Q0S5S0 Cluster: Glycine hydroxymethyltransferase; n=1;
Rhodococcus sp. RHA1|Rep: Glycine
hydroxymethyltransferase - Rhodococcus sp. (strain RHA1)
Length = 453
Score = 33.9 bits (74), Expect = 3.5
Identities = 46/188 (24%), Positives = 67/188 (35%), Gaps = 1/188 (0%)
Frame = +2
Query: 2 VAAGVIPSPF-EYCDIVTTTTHKTLRGPRAGVIFFRKGVRSVKANGQKVMYDLESKINQA 178
+AAG P E D+VT +T+KT GP G + + L +
Sbjct: 233 IAAGYYQDPLAEGADVVTFSTYKTFAGPAGGAAVTHSAEHAERLAAAAYPTMLSN----- 287
Query: 179 VFPGLQGGPHNHXXXXXXXXXXXXXXXEFVEYQKQVIKNAQRLCEGLISRGYSIATGGTD 358
+ + GP +EY ++ N L GL+ G + G T
Sbjct: 288 -YDPARLGPLAVAAGEAVDQSPPWAAVT-IEYAGELAANLNAL--GLVVVGRRL--GYTR 341
Query: 359 VHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISALNPSGIRLGTPALTTRGLKE 538
H ++D +G+G G A R LE + +P P G+RLG G
Sbjct: 342 SHQVVIDAQGIG-GGPAAVRRLEADGIYTGACRLPWQSPGTPPEGVRLGVQEFIRCG--- 397
Query: 539 ADIDKVVD 562
A D V D
Sbjct: 398 AGFDTVTD 405
>UniRef50_Q9VEP4 Cluster: CG5225-PA; n=2; Drosophila
melanogaster|Rep: CG5225-PA - Drosophila melanogaster
(Fruit fly)
Length = 594
Score = 33.9 bits (74), Expect = 3.5
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 2/48 (4%)
Frame = +1
Query: 103 PQGREVRQGERTEGHVR--FGIEDKPGCVPGPAGRTAQPRNSGHSHGH 240
P+G +GER E R +G+ +PG PGP G P GH GH
Sbjct: 93 PKGHTGSKGERGEKGERGHYGLPGQPG-EPGPIGPPGLPGPPGHKSGH 139
>UniRef50_Q6ZT39 Cluster: CDNA FLJ44991 fis, clone BRAWH3008867;
n=2; Homo sapiens|Rep: CDNA FLJ44991 fis, clone
BRAWH3008867 - Homo sapiens (Human)
Length = 145
Score = 33.9 bits (74), Expect = 3.5
Identities = 30/107 (28%), Positives = 50/107 (46%)
Frame = +2
Query: 302 RLCEGLISRGYSIATGGTDVHLALVDLRGVGLRGAPAERVLELCSVACNKNTVPGDISAL 481
+LC + G +A T + L V L GL L+LCSVA + + AL
Sbjct: 14 KLCSEALLSGGLVALEVTALKLCSVTLASGGLVALEVT-ALKLCSVALMSD----GLVAL 68
Query: 482 NPSGIRLGTPALTTRGLKEADIDKVVDFIDRALKIGLEIIKVSGLKL 622
+ ++L + AL + GL ++ + +L +GL ++V+ LKL
Sbjct: 69 EVTSLKLCSVALLSGGLVALEVTSLKLCSVASLSVGLVALEVTSLKL 115
>UniRef50_Q97AK0 Cluster: Serine hydroxymethyltransferase; n=3;
Thermoplasma|Rep: Serine hydroxymethyltransferase -
Thermoplasma volcanium
Length = 389
Score = 33.9 bits (74), Expect = 3.5
Identities = 13/32 (40%), Positives = 18/32 (56%)
Frame = +2
Query: 2 VAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVI 97
+A G CD+V +THKT GP+ G+I
Sbjct: 199 IAGGTFQKDIGLCDVVFGSTHKTFFGPQGGII 230
>UniRef50_O15026 Cluster: KIAA0309 protein; n=17; Eutheria|Rep:
KIAA0309 protein - Homo sapiens (Human)
Length = 3053
Score = 33.5 bits (73), Expect = 4.6
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = -1
Query: 633 LKSTSFSPETLMISRPIFNALSIKSTTLSISASLRPLVVNA-GVPSLMPLGLSALMSPGT 457
L + + +P T+ IS P+ + S + S++ L P+V A G PSL P G S S T
Sbjct: 1270 LPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALT 1329
Query: 456 VFLLQATLQSSS 421
+ L A SSS
Sbjct: 1330 LGLATAPSLSSS 1341
>UniRef50_UPI00006CE5B4 Cluster: hypothetical protein
TTHERM_00145660; n=1; Tetrahymena thermophila SB210|Rep:
hypothetical protein TTHERM_00145660 - Tetrahymena
thermophila SB210
Length = 2713
Score = 32.7 bits (71), Expect = 8.1
Identities = 14/42 (33%), Positives = 23/42 (54%)
Frame = -3
Query: 622 KFQPGNLNDF*TYFQCSINKIDNFINISFLETSCGQRWCTES 497
+F P + N+F ++ C IN ID+ N S G ++ TE+
Sbjct: 751 EFDPSSQNNFQEFYNCFINNIDDLKNESHKNFKLGMQFLTEN 792
>UniRef50_A6PKY5 Cluster: Putative uncharacterized protein; n=1;
Victivallis vadensis ATCC BAA-548|Rep: Putative
uncharacterized protein - Victivallis vadensis ATCC
BAA-548
Length = 1107
Score = 32.7 bits (71), Expect = 8.1
Identities = 33/133 (24%), Positives = 54/133 (40%), Gaps = 1/133 (0%)
Frame = -3
Query: 574 SINKIDNFINISFLETSCGQRWCTESDAAGVERXXXXXXXXXXXXXXA-ELEHALGRRAP 398
+++++ + ++ LE + G R ++DAAG E +++ R A
Sbjct: 531 ALDEVGDPDHLRLLEAAGGDRRGADADAAGHEGFLGIERDHVLIGGDMRDIQRVRHRLAG 590
Query: 397 QPDAAQIHEREVHVGXXXXXXXXXXX*TLAQPLRVLYHLFLIFDEFSSCSLFHGRGYGRY 218
+ AQ+ + +V VG L Q R+ HL LI E S GR
Sbjct: 591 RVLRAQVDQHQVVVGAAGNDPEAALDQLLRQLGRIQLHLMLIGLERRSQRFAEADRLGRD 650
Query: 217 CVVVRSALQAREH 179
++ R AL A EH
Sbjct: 651 HMLKRPALHAGEH 663
>UniRef50_Q5BWM4 Cluster: SJCHGC08526 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC08526 protein - Schistosoma
japonicum (Blood fluke)
Length = 301
Score = 32.7 bits (71), Expect = 8.1
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Frame = -1
Query: 609 ETLMISRPIFNALSIKSTTLS-ISASLRPLVVNAGVPSLMPLGLSALMSPGTVFLLQATL 433
E ++ +R I NA+++ TLS +S S R V++ VP + + T+ LQ T
Sbjct: 157 ENILCNRSIHNAMTVSPLTLSTLSTSSRTSVMSTTVPVGVAVITDTFYPTTTIITLQVTS 216
Query: 432 QSSST 418
++ST
Sbjct: 217 ANTST 221
>UniRef50_Q6C6R0 Cluster: Similar to DEHA0C07986g Debaryomyces
hansenii; n=1; Yarrowia lipolytica|Rep: Similar to
DEHA0C07986g Debaryomyces hansenii - Yarrowia lipolytica
(Candida lipolytica)
Length = 1518
Score = 32.7 bits (71), Expect = 8.1
Identities = 17/37 (45%), Positives = 21/37 (56%)
Frame = +2
Query: 455 TVPGDISALNPSGIRLGTPALTTRGLKEADIDKVVDF 565
T+P D++A P I LGT TTR + D VVDF
Sbjct: 1177 TLPTDVTADIPKPIALGTDPATTRAVSAIDRIPVVDF 1213
>UniRef50_Q9NZR2 Cluster: Low-density lipoprotein receptor-related
protein 1B precursor; n=65; Euteleostomi|Rep: Low-density
lipoprotein receptor-related protein 1B precursor - Homo
sapiens (Human)
Length = 4599
Score = 32.7 bits (71), Expect = 8.1
Identities = 11/17 (64%), Positives = 15/17 (88%)
Frame = +3
Query: 348 AAPTCTSRSWICAASGC 398
A+PTC+SR +ICA+ GC
Sbjct: 3590 ASPTCSSREYICASDGC 3606
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 586,663,775
Number of Sequences: 1657284
Number of extensions: 11311661
Number of successful extensions: 38749
Number of sequences better than 10.0: 70
Number of HSP's better than 10.0 without gapping: 37047
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 38642
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 50413227838
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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