Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte3d03
(773 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AJ133727-1|CAB42630.1| 889|Homo sapiens hyperpolarization-activ... 64 5e-10
AJ012582-1|CAB42602.1| 889|Homo sapiens hyperpolarization-activ... 64 5e-10
AF065164-1|AAC28444.2| 889|Homo sapiens hyperpolarization-activ... 64 5e-10
AF064877-1|AAC39760.1| 597|Homo sapiens ion channel BCNG-2 prot... 64 5e-10
AJ238850-1|CAB52754.1| 1203|Homo sapiens hyperpolarization-activ... 58 5e-08
AJ132429-1|CAB42604.1| 1203|Homo sapiens hyperpolarization-activ... 58 5e-08
AF064876-1|AAC39759.1| 749|Homo sapiens ion channel BCNG-1 prot... 55 2e-07
BC028024-1|AAH28024.2| 450|Homo sapiens HCN3 protein protein. 53 1e-06
BC000066-1|AAH00066.1| 571|Homo sapiens Unknown (protein for IM... 53 1e-06
AL713999-31|CAI95100.1| 774|Homo sapiens hyperpolarization acti... 53 1e-06
AF488550-1|AAO49470.1| 774|Homo sapiens hyperpolarization activ... 53 1e-06
AB040968-1|BAA96059.2| 711|Homo sapiens KIAA1535 protein protein. 53 1e-06
AY563507-1|AAT67985.1| 1516|Homo sapiens KIAA2022 protein. 32 2.6
AL139395-1|CAI39510.1| 1516|Homo sapiens novel protein protein. 32 2.6
AB095942-1|BAC23118.1| 1520|Homo sapiens KIAA2022 protein protein. 32 2.6
>AJ133727-1|CAB42630.1| 889|Homo sapiens hyperpolarization-activated
cyclic nucleotide-gated channel hHCN2 protein.
Length = 889
Score = 64.1 bits (149), Expect = 5e-10
Identities = 51/209 (24%), Positives = 91/209 (43%), Gaps = 2/209 (0%)
Frame = +2
Query: 146 PRNCSWMTVGNLWNATSEIRFTFALNRAVG-MLRTNSNLHIIEQIDLCSQSFYIVSWLIA 322
PRNC W+++ + N + ++FAL +A+ ML E + + + + +I
Sbjct: 395 PRNC-WVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESM---TDIWLTMLSMIV 450
Query: 323 KLLIYHSCLKYIVSLFGSESASARYYIMT-KQVVNYMNQXXXXXXXXXXXXXXYNIRFQS 499
Y + + +L S +S R Y KQV YM+ Y R+Q
Sbjct: 451 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG 510
Query: 500 NFLMESRMIDCVSGQLREDIIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDI 679
E ++ ++G LRE+I+ R+LV + + + KL +F GD
Sbjct: 511 KMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDY 570
Query: 680 IFKINSVGDCVYFIDKGTVAIYSESGKEV 766
I + ++G +YFI G V++ ++ KE+
Sbjct: 571 IIREGTIGKKMYFIQHGVVSVLTKGNKEM 599
>AJ012582-1|CAB42602.1| 889|Homo sapiens hyperpolarization-activated
cation channel HCN2 protein.
Length = 889
Score = 64.1 bits (149), Expect = 5e-10
Identities = 51/209 (24%), Positives = 91/209 (43%), Gaps = 2/209 (0%)
Frame = +2
Query: 146 PRNCSWMTVGNLWNATSEIRFTFALNRAVG-MLRTNSNLHIIEQIDLCSQSFYIVSWLIA 322
PRNC W+++ + N + ++FAL +A+ ML E + + + + +I
Sbjct: 395 PRNC-WVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESM---TDIWLTMLSMIV 450
Query: 323 KLLIYHSCLKYIVSLFGSESASARYYIMT-KQVVNYMNQXXXXXXXXXXXXXXYNIRFQS 499
Y + + +L S +S R Y KQV YM+ Y R+Q
Sbjct: 451 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG 510
Query: 500 NFLMESRMIDCVSGQLREDIIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDI 679
E ++ ++G LRE+I+ R+LV + + + KL +F GD
Sbjct: 511 KMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDY 570
Query: 680 IFKINSVGDCVYFIDKGTVAIYSESGKEV 766
I + ++G +YFI G V++ ++ KE+
Sbjct: 571 IIREGTIGKKMYFIQHGVVSVLTKGNKEM 599
>AF065164-1|AAC28444.2| 889|Homo sapiens hyperpolarization-activated,
cyclic nucleotide-gated channel 2 protein.
Length = 889
Score = 64.1 bits (149), Expect = 5e-10
Identities = 51/209 (24%), Positives = 91/209 (43%), Gaps = 2/209 (0%)
Frame = +2
Query: 146 PRNCSWMTVGNLWNATSEIRFTFALNRAVG-MLRTNSNLHIIEQIDLCSQSFYIVSWLIA 322
PRNC W+++ + N + ++FAL +A+ ML E + + + + +I
Sbjct: 395 PRNC-WVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESM---TDIWLTMLSMIV 450
Query: 323 KLLIYHSCLKYIVSLFGSESASARYYIMT-KQVVNYMNQXXXXXXXXXXXXXXYNIRFQS 499
Y + + +L S +S R Y KQV YM+ Y R+Q
Sbjct: 451 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG 510
Query: 500 NFLMESRMIDCVSGQLREDIIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDI 679
E ++ ++G LRE+I+ R+LV + + + KL +F GD
Sbjct: 511 KMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDY 570
Query: 680 IFKINSVGDCVYFIDKGTVAIYSESGKEV 766
I + ++G +YFI G V++ ++ KE+
Sbjct: 571 IIREGTIGKKMYFIQHGVVSVLTKGNKEM 599
>AF064877-1|AAC39760.1| 597|Homo sapiens ion channel BCNG-2
protein.
Length = 597
Score = 64.1 bits (149), Expect = 5e-10
Identities = 51/209 (24%), Positives = 91/209 (43%), Gaps = 2/209 (0%)
Frame = +2
Query: 146 PRNCSWMTVGNLWNATSEIRFTFALNRAVG-MLRTNSNLHIIEQIDLCSQSFYIVSWLIA 322
PRNC W+++ + N + ++FAL +A+ ML E + + + + +I
Sbjct: 249 PRNC-WVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESM---TDIWLTMLSMIV 304
Query: 323 KLLIYHSCLKYIVSLFGSESASARYYIMT-KQVVNYMNQXXXXXXXXXXXXXXYNIRFQS 499
Y + + +L S +S R Y KQV YM+ Y R+Q
Sbjct: 305 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG 364
Query: 500 NFLMESRMIDCVSGQLREDIIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDI 679
E ++ ++G LRE+I+ R+LV + + + KL +F GD
Sbjct: 365 KMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDY 424
Query: 680 IFKINSVGDCVYFIDKGTVAIYSESGKEV 766
I + ++G +YFI G V++ ++ KE+
Sbjct: 425 IIREGTIGKKMYFIQHGVVSVLTKGNKEM 453
>AJ238850-1|CAB52754.1| 1203|Homo sapiens hyperpolarization-activated
channel type 4 protein.
Length = 1203
Score = 57.6 bits (133), Expect = 5e-08
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 2/208 (0%)
Frame = +2
Query: 146 PRNCSWMTVGNLWNATSEIRFTFALNRAVGMLRTNSNLHIIEQIDLCSQSFYIVSW-LIA 322
P +C W+++ N+ N + ++++AL +A+ + + Q + ++ +I
Sbjct: 446 PDDC-WVSINNMVNNSWGKQYSYALFKAMSHMLC---IGYGRQAPVGMSDVWLTMLSMIV 501
Query: 323 KLLIYHSCLKYIVSLFGSESASARYYIMT-KQVVNYMNQXXXXXXXXXXXXXXYNIRFQS 499
Y + + +L S +S R Y KQV YM+ Y R+Q
Sbjct: 502 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQG 561
Query: 500 NFLMESRMIDCVSGQLREDIIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDI 679
E ++ +S LRE+II R+LV + + + KL +F GD
Sbjct: 562 KMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDY 621
Query: 680 IFKINSVGDCVYFIDKGTVAIYSESGKE 763
I + ++G +YFI G V++ ++ KE
Sbjct: 622 IIREGTIGKKMYFIQHGVVSVLTKGNKE 649
>AJ132429-1|CAB42604.1| 1203|Homo sapiens hyperpolarization-activated
cyclic nucleotide gated cation channel hHCN4 protein.
Length = 1203
Score = 57.6 bits (133), Expect = 5e-08
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 2/208 (0%)
Frame = +2
Query: 146 PRNCSWMTVGNLWNATSEIRFTFALNRAVGMLRTNSNLHIIEQIDLCSQSFYIVSW-LIA 322
P +C W+++ N+ N + ++++AL +A+ + + Q + ++ +I
Sbjct: 446 PDDC-WVSINNMVNNSWGKQYSYALFKAMSHMLC---IGYGRQAPVGMSDVWLTMLSMIV 501
Query: 323 KLLIYHSCLKYIVSLFGSESASARYYIMT-KQVVNYMNQXXXXXXXXXXXXXXYNIRFQS 499
Y + + +L S +S R Y KQV YM+ Y R+Q
Sbjct: 502 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQG 561
Query: 500 NFLMESRMIDCVSGQLREDIIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDI 679
E ++ +S LRE+II R+LV + + + KL +F GD
Sbjct: 562 KMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDY 621
Query: 680 IFKINSVGDCVYFIDKGTVAIYSESGKE 763
I + ++G +YFI G V++ ++ KE
Sbjct: 622 IIREGTIGKKMYFIQHGVVSVLTKGNKE 649
>AF064876-1|AAC39759.1| 749|Homo sapiens ion channel BCNG-1
protein.
Length = 749
Score = 55.2 bits (127), Expect = 2e-07
Identities = 47/209 (22%), Positives = 89/209 (42%), Gaps = 2/209 (0%)
Frame = +2
Query: 146 PRNCSWMTVGNLWNATSEIRFTFALNRAVGMLRTNSNLHIIEQIDLCSQSFYIVSW-LIA 322
P +C W+++ + N + ++++AL +A+ + + Q + +I +I
Sbjct: 205 PPDC-WVSLNEMVNDSWGKQYSYALFKAMSHMLC---IGYGAQAPVSMSDLWITMLSMIV 260
Query: 323 KLLIYHSCLKYIVSLFGSESASARYYIMT-KQVVNYMNQXXXXXXXXXXXXXXYNIRFQS 499
Y + + +L S +S R Y KQV YM+ Y R+Q
Sbjct: 261 GATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQG 320
Query: 500 NFLMESRMIDCVSGQLREDIIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDI 679
E +++ ++ LRE+I+ R+LV + + + KL +F GD
Sbjct: 321 KIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDY 380
Query: 680 IFKINSVGDCVYFIDKGTVAIYSESGKEV 766
I + +VG +YFI G + ++S KE+
Sbjct: 381 IIREGAVGKKMYFIQHGVAGVITKSSKEM 409
>BC028024-1|AAH28024.2| 450|Homo sapiens HCN3 protein protein.
Length = 450
Score = 53.2 bits (122), Expect = 1e-06
Identities = 33/129 (25%), Positives = 56/129 (43%)
Frame = +2
Query: 377 ESASARYYIMTKQVVNYMNQXXXXXXXXXXXXXXYNIRFQSNFLMESRMIDCVSGQLRED 556
+S+ +Y KQV YM+ Y R+Q E ++ +S LRE+
Sbjct: 30 DSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREE 89
Query: 557 IIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDIIFKINSVGDCVYFIDKGTV 736
II T R LV + + + KL +F GD++ + SVG +YFI G +
Sbjct: 90 IINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLL 149
Query: 737 AIYSESGKE 763
++ + ++
Sbjct: 150 SVLARGARD 158
>BC000066-1|AAH00066.1| 571|Homo sapiens Unknown (protein for
IMAGE:3507934) protein.
Length = 571
Score = 53.2 bits (122), Expect = 1e-06
Identities = 33/129 (25%), Positives = 56/129 (43%)
Frame = +2
Query: 377 ESASARYYIMTKQVVNYMNQXXXXXXXXXXXXXXYNIRFQSNFLMESRMIDCVSGQLRED 556
+S+ +Y KQV YM+ Y R+Q E ++ +S LRE+
Sbjct: 151 DSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREE 210
Query: 557 IIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDIIFKINSVGDCVYFIDKGTV 736
II T R LV + + + KL +F GD++ + SVG +YFI G +
Sbjct: 211 IINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLL 270
Query: 737 AIYSESGKE 763
++ + ++
Sbjct: 271 SVLARGARD 279
>AL713999-31|CAI95100.1| 774|Homo sapiens hyperpolarization
activated cyclic nucleotide-gated potassium channel 3
protein.
Length = 774
Score = 53.2 bits (122), Expect = 1e-06
Identities = 33/129 (25%), Positives = 56/129 (43%)
Frame = +2
Query: 377 ESASARYYIMTKQVVNYMNQXXXXXXXXXXXXXXYNIRFQSNFLMESRMIDCVSGQLRED 556
+S+ +Y KQV YM+ Y R+Q E ++ +S LRE+
Sbjct: 354 DSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREE 413
Query: 557 IIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDIIFKINSVGDCVYFIDKGTV 736
II T R LV + + + KL +F GD++ + SVG +YFI G +
Sbjct: 414 IINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLL 473
Query: 737 AIYSESGKE 763
++ + ++
Sbjct: 474 SVLARGARD 482
>AF488550-1|AAO49470.1| 774|Homo sapiens hyperpolarization
activated cyclic nucleotide-gated potassium channel
protein.
Length = 774
Score = 53.2 bits (122), Expect = 1e-06
Identities = 33/129 (25%), Positives = 56/129 (43%)
Frame = +2
Query: 377 ESASARYYIMTKQVVNYMNQXXXXXXXXXXXXXXYNIRFQSNFLMESRMIDCVSGQLRED 556
+S+ +Y KQV YM+ Y R+Q E ++ +S LRE+
Sbjct: 354 DSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREE 413
Query: 557 IIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDIIFKINSVGDCVYFIDKGTV 736
II T R LV + + + KL +F GD++ + SVG +YFI G +
Sbjct: 414 IINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLL 473
Query: 737 AIYSESGKE 763
++ + ++
Sbjct: 474 SVLARGARD 482
>AB040968-1|BAA96059.2| 711|Homo sapiens KIAA1535 protein protein.
Length = 711
Score = 53.2 bits (122), Expect = 1e-06
Identities = 33/129 (25%), Positives = 56/129 (43%)
Frame = +2
Query: 377 ESASARYYIMTKQVVNYMNQXXXXXXXXXXXXXXYNIRFQSNFLMESRMIDCVSGQLRED 556
+S+ +Y KQV YM+ Y R+Q E ++ +S LRE+
Sbjct: 291 DSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREE 350
Query: 557 IIMHTGRQLVREVEFLKQLPRPLLVQIGFKLHVVIFIAGDIIFKINSVGDCVYFIDKGTV 736
II T R LV + + + KL +F GD++ + SVG +YFI G +
Sbjct: 351 IINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLL 410
Query: 737 AIYSESGKE 763
++ + ++
Sbjct: 411 SVLARGARD 419
>AY563507-1|AAT67985.1| 1516|Homo sapiens KIAA2022 protein.
Length = 1516
Score = 31.9 bits (69), Expect = 2.6
Identities = 16/47 (34%), Positives = 23/47 (48%)
Frame = -3
Query: 747 EYIATVPLSMK*TQSPTEFILKIISPAINITTCNLKPICTNKGLGNC 607
E++A V + TQS +++S N+T PIC N G NC
Sbjct: 899 EFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNC 945
>AL139395-1|CAI39510.1| 1516|Homo sapiens novel protein protein.
Length = 1516
Score = 31.9 bits (69), Expect = 2.6
Identities = 16/47 (34%), Positives = 23/47 (48%)
Frame = -3
Query: 747 EYIATVPLSMK*TQSPTEFILKIISPAINITTCNLKPICTNKGLGNC 607
E++A V + TQS +++S N+T PIC N G NC
Sbjct: 899 EFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNC 945
>AB095942-1|BAC23118.1| 1520|Homo sapiens KIAA2022 protein protein.
Length = 1520
Score = 31.9 bits (69), Expect = 2.6
Identities = 16/47 (34%), Positives = 23/47 (48%)
Frame = -3
Query: 747 EYIATVPLSMK*TQSPTEFILKIISPAINITTCNLKPICTNKGLGNC 607
E++A V + TQS +++S N+T PIC N G NC
Sbjct: 903 EFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNC 949
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 106,767,899
Number of Sequences: 237096
Number of extensions: 2179308
Number of successful extensions: 3751
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 3633
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3745
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 9367263024
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -