Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte29d02
(702 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-depend... 233 2e-60
UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 230 2e-59
UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 216 4e-55
UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila pseudoobscu... 215 9e-55
UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5; Euka... 207 2e-52
UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent In... 199 5e-50
UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3, mi... 196 6e-49
UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putati... 194 2e-48
UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information... 191 2e-47
UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1; ... 190 3e-47
UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2; ... 190 4e-47
UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1; ... 190 4e-47
UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2; O... 185 1e-45
UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family ... 184 2e-45
UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU005... 183 3e-45
UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome s... 182 6e-45
UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n... 181 2e-44
UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona intesti... 180 3e-44
UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1; ... 180 4e-44
UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=... 178 9e-44
UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella ve... 172 8e-42
UniRef50_Q750H1 Cluster: AGL018Cp; n=1; Eremothecium gossypii|Re... 172 8e-42
UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase, puta... 172 8e-42
UniRef50_P53686 Cluster: NAD-dependent deacetylase HST2; n=4; Sa... 171 2e-41
UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces cere... 170 2e-41
UniRef50_O94066 Cluster: Transcription regulatory protein; n=6; ... 170 3e-41
UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1; Dict... 169 4e-41
UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional regu... 167 3e-40
UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2; ... 166 4e-40
UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1; ... 165 1e-39
UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putati... 160 3e-38
UniRef50_UPI00005A356B Cluster: PREDICTED: similar to NAD-depend... 159 5e-38
UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family ... 159 6e-38
UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family ... 159 8e-38
UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional regu... 157 2e-37
UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putati... 156 6e-37
UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 153 5e-36
UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent in... 151 1e-35
UniRef50_Q4DP02 Cluster: Silent information regulator 2, putativ... 145 8e-34
UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=... 145 8e-34
UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;... 145 8e-34
UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1; Fil... 145 1e-33
UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona intesti... 144 1e-33
UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152, w... 144 1e-33
UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA... 144 2e-33
UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2 ... 143 4e-33
UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;... 141 2e-32
UniRef50_Q5BVF7 Cluster: SJCHGC03105 protein; n=2; Schistosoma j... 140 2e-32
UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;... 140 2e-32
UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-depend... 140 3e-32
UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lambl... 139 7e-32
UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein NCU047... 138 1e-31
UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 - Droso... 136 4e-31
UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtui... 136 6e-31
UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18... 136 6e-31
UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;... 135 1e-30
UniRef50_UPI0001555321 Cluster: PREDICTED: similar to sirtuin (s... 132 1e-29
UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;... 128 1e-28
UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of s... 126 4e-28
UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1; ... 126 5e-28
UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1; ... 126 7e-28
UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family ... 125 1e-27
UniRef50_Q7QZ37 Cluster: GLP_464_19573_21615; n=1; Giardia lambl... 124 2e-27
UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family ... 124 3e-27
UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family ... 122 6e-27
UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1; ... 122 6e-27
UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;... 122 9e-27
UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1; ... 122 1e-26
UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1; ... 121 2e-26
UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;... 121 2e-26
UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145, w... 119 6e-26
UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1... 118 1e-25
UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;... 117 3e-25
UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;... 117 3e-25
UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetyla... 116 6e-25
UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;... 115 1e-24
UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1; ... 114 2e-24
UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of str... 114 2e-24
UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1; ... 113 4e-24
UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family ... 93 5e-18
UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR... 91 2e-17
UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family ... 91 3e-17
UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4; Thermot... 90 6e-17
UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2; Filobasidi... 85 2e-15
UniRef50_A6DC77 Cluster: Silent information regulator protein Si... 83 5e-15
UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family ... 83 5e-15
UniRef50_Q54LF0 Cluster: Ankyrin repeat-containing protein; n=1;... 83 6e-15
UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2; ... 81 2e-14
UniRef50_A4M603 Cluster: Silent information regulator protein Si... 81 2e-14
UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7; Bacteri... 80 6e-14
UniRef50_Q6BPA4 Cluster: Debaryomyces hansenii chromosome E of s... 79 1e-13
UniRef50_A6LP94 Cluster: Silent information regulator protein Si... 79 1e-13
UniRef50_UPI000049979A Cluster: Sir2 family transcriptional regu... 77 3e-13
UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1; S... 77 3e-13
UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1; Therm... 77 3e-13
UniRef50_A7HL19 Cluster: Silent information regulator protein Si... 76 1e-12
UniRef50_A4J646 Cluster: Silent information regulator protein Si... 76 1e-12
UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3; Bacte... 75 2e-12
UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellul... 75 2e-12
UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacill... 74 3e-12
UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Trepone... 73 9e-12
UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;... 72 2e-11
UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces cere... 71 2e-11
UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3; Pyrob... 71 4e-11
UniRef50_Q2HG51 Cluster: Putative uncharacterized protein; n=2; ... 70 5e-11
UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14; Bacill... 69 1e-10
UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2 ... 69 1e-10
UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8; Thermop... 68 3e-10
UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3; Bacillu... 68 3e-10
UniRef50_UPI000049971A Cluster: Sir2 family transcriptional regu... 66 6e-10
UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1; Symbiob... 66 6e-10
UniRef50_Q9UR39 Cluster: NAD-dependent deacetylase hst4; n=1; Sc... 66 8e-10
UniRef50_Q0UMU7 Cluster: Putative uncharacterized protein; n=1; ... 66 1e-09
UniRef50_Q12Y78 Cluster: Silent information regulator protein Si... 66 1e-09
UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17; Staphy... 65 1e-09
UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1; ... 65 2e-09
UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putati... 65 2e-09
UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7; Bacil... 64 2e-09
UniRef50_A5UYK2 Cluster: Silent information regulator protein Si... 64 4e-09
UniRef50_Q4WT50 Cluster: SIR2 family histone deacetylase (Hst4),... 64 4e-09
UniRef50_A6R1B0 Cluster: Predicted protein; n=2; Onygenales|Rep:... 64 4e-09
UniRef50_A4RMS1 Cluster: Putative uncharacterized protein; n=2; ... 64 4e-09
UniRef50_UPI000023E2DA Cluster: hypothetical protein FG00460.1; ... 63 6e-09
UniRef50_A0LG97 Cluster: Silent information regulator protein Si... 62 1e-08
UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC... 62 1e-08
UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 62 1e-08
UniRef50_A0NQ49 Cluster: Silent information regulator protein Si... 62 1e-08
UniRef50_A6PTK3 Cluster: Silent information regulator protein Si... 62 2e-08
UniRef50_Q4P2A5 Cluster: Putative uncharacterized protein; n=1; ... 61 2e-08
UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3; Fusobac... 61 2e-08
UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2... 60 4e-08
UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 60 5e-08
UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4; Leptosp... 60 7e-08
UniRef50_Q5KG84 Cluster: Hst4 protein, putative; n=2; Filobasidi... 54 7e-08
UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3; Actin... 59 1e-07
UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4; Pseud... 59 1e-07
UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1; ... 58 2e-07
UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin ... 58 2e-07
UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6; Coryn... 58 2e-07
UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep: ... 58 3e-07
UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140... 58 3e-07
UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida albic... 58 3e-07
UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1; ... 57 4e-07
UniRef50_Q6CB00 Cluster: Similarities with tr|Q9UR39 Schizosacch... 57 4e-07
UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellul... 57 4e-07
UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|R... 56 6e-07
UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona intesti... 56 6e-07
UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces ha... 56 6e-07
UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1; Microsc... 56 1e-06
UniRef50_Q7R0R8 Cluster: GLP_79_6121_4343; n=1; Giardia lamblia ... 56 1e-06
UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12; Prot... 56 1e-06
UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2... 55 1e-06
UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6; Pseud... 55 1e-06
UniRef50_Q3E2I1 Cluster: Silent information regulator protein Si... 55 2e-06
UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellu... 55 2e-06
UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gamb... 54 3e-06
UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=... 54 3e-06
UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4 CG31... 54 3e-06
UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5; Catarrhini... 54 3e-06
UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candida... 54 3e-06
UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6; ... 54 3e-06
UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9; Bacteri... 54 3e-06
UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4; Lactoba... 54 3e-06
UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetyla... 54 4e-06
UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella ve... 54 4e-06
UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1; No... 53 6e-06
UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-P... 53 6e-06
UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=... 53 6e-06
UniRef50_A1FG80 Cluster: Silent information regulator protein Si... 53 8e-06
UniRef50_Q7SB01 Cluster: Putative uncharacterized protein NCU076... 53 8e-06
UniRef50_A6TNA0 Cluster: Silent information regulator protein Si... 52 1e-05
UniRef50_A1HLU5 Cluster: Silent information regulator protein Si... 52 1e-05
UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:... 52 1e-05
UniRef50_Q5CYK0 Cluster: Bacterial-like Sir2 family protein; n=2... 52 1e-05
UniRef50_Q7S223 Cluster: Putative uncharacterized protein NCU059... 52 1e-05
UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2; Cae... 52 2e-05
UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2... 52 2e-05
UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14; Mycoba... 52 2e-05
UniRef50_Q4RA56 Cluster: Chromosome undetermined SCAF24448, whol... 51 2e-05
UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus thur... 51 2e-05
UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP ribosyltransf... 51 2e-05
UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2; ... 51 2e-05
UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2; Microsc... 50 4e-05
UniRef50_Q62HT8 Cluster: Transcriptional regulator, Sir2 family;... 50 6e-05
UniRef50_Q0LN22 Cluster: Silent information regulator protein Si... 50 7e-05
UniRef50_A6G0H3 Cluster: Silent information regulator protein Si... 50 7e-05
UniRef50_A1HU63 Cluster: Silent information regulator protein Si... 50 7e-05
UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.... 50 7e-05
UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family ... 50 7e-05
UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8; Actin... 50 7e-05
UniRef50_P53688 Cluster: NAD-dependent histone deacetylase HST4;... 50 7e-05
UniRef50_A5USR3 Cluster: Silent information regulator protein Si... 49 1e-04
UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putati... 49 1e-04
UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3; ... 49 1e-04
UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to... 49 1e-04
UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4; Prote... 48 2e-04
UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1; Myco... 48 2e-04
UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent in... 48 2e-04
UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11; Bacter... 48 2e-04
UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305... 48 2e-04
UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Re... 48 2e-04
UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12; Magnoliophyt... 48 3e-04
UniRef50_A7DQD6 Cluster: Silent information regulator protein Si... 48 3e-04
UniRef50_A5WD15 Cluster: Silent information regulator protein Si... 47 4e-04
UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins... 47 4e-04
UniRef50_A6RSV6 Cluster: Putative uncharacterized protein; n=2; ... 47 4e-04
UniRef50_A6WG46 Cluster: Silent information regulator protein Si... 47 5e-04
UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13; Campyl... 47 5e-04
UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9; Coryn... 47 5e-04
UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family ... 46 7e-04
UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=... 46 7e-04
UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5 ... 46 9e-04
UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family ... 46 9e-04
UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2; Halobac... 46 9e-04
UniRef50_A0JXS0 Cluster: Silent information regulator protein Si... 46 0.001
UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lambli... 46 0.001
UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;... 46 0.001
UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4; Deinoco... 46 0.001
UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5; Pseud... 46 0.001
UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family ... 45 0.002
UniRef50_Q2GZ88 Cluster: Putative uncharacterized protein; n=1; ... 45 0.002
UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9; Prote... 45 0.002
UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA... 45 0.002
UniRef50_Q7S386 Cluster: Putative uncharacterized protein NCU048... 45 0.002
UniRef50_A4UCE7 Cluster: Putative uncharacterized protein; n=1; ... 45 0.002
UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein... 44 0.004
UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus xa... 44 0.004
UniRef50_A7H7B6 Cluster: Silent information regulator protein Si... 44 0.004
UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin (s... 44 0.005
UniRef50_UPI000023F1DF Cluster: hypothetical protein FG02466.1; ... 44 0.005
UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2; Bifi... 44 0.005
UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis ... 43 0.006
UniRef50_A5DW75 Cluster: Putative uncharacterized protein; n=1; ... 43 0.008
UniRef50_A6Q946 Cluster: Transcriptional regulator, Sir2 family;... 42 0.011
UniRef50_A6Q178 Cluster: Transcription regulator, Sir2 family; n... 42 0.011
UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2; Bifi... 42 0.011
UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to ENSANGP000... 42 0.015
UniRef50_A4JJP4 Cluster: Silent information regulator protein Si... 42 0.015
UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the Si... 42 0.015
UniRef50_Q6QGI5 Cluster: Putative Sir2-like protein; n=2; Entero... 42 0.019
UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1; Methylo... 42 0.019
UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma p... 41 0.034
UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10; Bact... 41 0.034
UniRef50_A4A8B4 Cluster: Silent information regulator protein Si... 40 0.045
UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thalia... 40 0.045
UniRef50_Q1MT39 Cluster: Novel protein similar to vertebratesirt... 40 0.059
UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococ... 40 0.059
UniRef50_A3U6J8 Cluster: Beta-ketoacyl synthase; n=3; Flavobacte... 40 0.078
UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11; Bacter... 40 0.078
UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2; A... 39 0.10
UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;... 39 0.10
UniRef50_A7HID4 Cluster: Silent information regulator protein Si... 39 0.14
UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellu... 39 0.14
UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1; ... 38 0.18
UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2; Marinob... 38 0.24
UniRef50_Q5BVX8 Cluster: SJCHGC08739 protein; n=1; Schistosoma j... 38 0.24
UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative... 38 0.24
UniRef50_A1ZMS1 Cluster: Silent information regulator protein Si... 38 0.32
UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1; ... 38 0.32
UniRef50_Q1EP52 Cluster: Transcriptional regulator Sir2 family p... 37 0.42
UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium (Vin... 37 0.42
UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1; ... 37 0.55
UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4; ... 36 0.73
UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35; Bacter... 36 0.96
UniRef50_Q23A43 Cluster: Transcriptional regulator, Sir2 family ... 35 1.7
UniRef50_Q8N6T7-3 Cluster: Isoform 3 of Q8N6T7 ; n=2; Catarrhini... 35 2.2
UniRef50_A4A980 Cluster: NAD-dependent deacetylase; n=5; Gammapr... 35 2.2
UniRef50_A4A8M6 Cluster: Putative uncharacterized protein; n=1; ... 34 2.9
UniRef50_UPI000155CCB0 Cluster: PREDICTED: similar to NREBP; n=1... 34 3.9
UniRef50_Q4T320 Cluster: Chromosome undetermined SCAF10132, whol... 34 3.9
UniRef50_A0YUL1 Cluster: Peptidase C14, caspase catalytic subuni... 34 3.9
UniRef50_Q56EG8 Cluster: Gp31.1; n=2; unclassified T4-like virus... 34 3.9
UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, wh... 34 3.9
UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein d... 33 5.1
UniRef50_UPI000023E8EE Cluster: hypothetical protein FG03153.1; ... 33 5.1
UniRef50_Q4HM93 Cluster: Regulatory SIR2 family protein, putativ... 33 5.1
UniRef50_Q23YS7 Cluster: Transcriptional regulator, Sir2 family ... 33 5.1
UniRef50_A0DQW0 Cluster: Chromosome undetermined scaffold_6, who... 33 5.1
UniRef50_Q2GRB1 Cluster: Predicted protein; n=1; Chaetomium glob... 33 5.1
UniRef50_Q6CHN4 Cluster: Similar to tr|Q96QF7 Homo sapiens NAAR1... 33 6.8
UniRef50_Q4DNW3 Cluster: DNA repair protein BRCA2, putative; n=1... 33 9.0
UniRef50_A4YD01 Cluster: Triphosphoribosyl-dephospho-CoA protein... 33 9.0
UniRef50_Q27115 Cluster: Glucose transporter HT1; n=13; Trypanos... 33 9.0
>UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog - Strongylocentrotus
purpuratus
Length = 400
Score = 233 bits (571), Expect = 2e-60
Identities = 107/172 (62%), Positives = 138/172 (80%), Gaps = 1/172 (0%)
Frame = +2
Query: 188 DLDVDDVRMYLALKLGLFSPQDLEPAEP-PEKVLDEVSLDGIVRWIKSDRCKKIITLSGA 364
D V+ +R +L + L + + +P PE++L E++L+GI +IK +CKK+I +SGA
Sbjct: 24 DSQVESLRNFLG-RFHLSAGSSGQEEKPKPEQLLKELTLEGIADFIKEGKCKKVIVMSGA 82
Query: 365 GISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKP 544
GISTSAGIPDFR+P TGLY NLQKY LP PQAIFEI FF+QNP+PFFTL+KELFPG+F P
Sbjct: 83 GISTSAGIPDFRTPGTGLYDNLQKYNLPNPQAIFEIGFFKQNPEPFFTLSKELFPGAFYP 142
Query: 545 TISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
T SH+FI LLHEKG+LLRHYTQNID L+R AG+P+E ++EAHG+F+T HCL+
Sbjct: 143 TPSHFFIHLLHEKGILLRHYTQNIDGLDRMAGVPDELIMEAHGSFHTGHCLN 194
>UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=31;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Homo sapiens (Human)
Length = 389
Score = 230 bits (563), Expect = 2e-59
Identities = 104/154 (67%), Positives = 131/154 (85%)
Frame = +2
Query: 236 LFSPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETG 415
LFS Q L E++LDE++L+G+ R+++S+RC+++I L GAGISTSAGIPDFRSP TG
Sbjct: 44 LFS-QTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTG 102
Query: 416 LYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLL 595
LY NL+KY LP P+AIFEI++F+++P+PFF LAKEL+PG FKPTI HYF+RLL +KGLLL
Sbjct: 103 LYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLL 162
Query: 596 RHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
R YTQNIDTLER AG+ +E LVEAHGTFYTSHC+
Sbjct: 163 RCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 196
>UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=12;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 379
Score = 216 bits (528), Expect = 4e-55
Identities = 95/143 (66%), Positives = 121/143 (84%)
Frame = +2
Query: 269 PPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELP 448
P +KVLDE++LD + R+I S +CK II + GAGISTSAGIPDFRSP TGLY NLQKY LP
Sbjct: 52 PGDKVLDELTLDSVARYILSGKCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLP 111
Query: 449 QPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
P+AIF+I++F+++P+PFF LA+EL+PG FKPT+ HYFI++L +KGLL R Y+QNIDTLE
Sbjct: 112 YPEAIFQIDYFKKHPEPFFALARELYPGQFKPTVYHYFIKMLKDKGLLRRCYSQNIDTLE 171
Query: 629 RGAGIPEEKLVEAHGTFYTSHCL 697
R AG+ E L+EAHGTF+TSHC+
Sbjct: 172 RVAGLEGEDLIEAHGTFHTSHCV 194
>UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila
pseudoobscura|Rep: GA18650-PA - Drosophila pseudoobscura
(Fruit fly)
Length = 381
Score = 215 bits (525), Expect = 9e-55
Identities = 102/169 (60%), Positives = 129/169 (76%)
Frame = +2
Query: 191 LDVDDVRMYLALKLGLFSPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGI 370
L VD + LA L + P + EKV+ +++ G+ + + KKIIT+ GAGI
Sbjct: 31 LTVDGISRLLASTLNV-GPSS---TKEKEKVIADLTFKGLADHWRENGFKKIITMVGAGI 86
Query: 371 STSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTI 550
STSAGIPDFRSP +GLY NL KY+LP P AIFE+ +F++ P PFF LAKEL+PGSF+PT
Sbjct: 87 STSAGIPDFRSPGSGLYDNLAKYKLPYPTAIFELGYFKKKPAPFFALAKELYPGSFEPTT 146
Query: 551 SHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+HYFIRLLHEKGLLLRHYTQNIDTL+R AGIP+EKL+EAHG+F+T+HC+
Sbjct: 147 AHYFIRLLHEKGLLLRHYTQNIDTLDRLAGIPDEKLIEAHGSFHTNHCI 195
>UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5;
Eukaryota|Rep: Zn finger-containing protein -
Dictyostelium discoideum AX4
Length = 512
Score = 207 bits (506), Expect = 2e-52
Identities = 94/155 (60%), Positives = 123/155 (79%), Gaps = 1/155 (0%)
Frame = +2
Query: 236 LFSPQDLEPAEPPEK-VLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPET 412
+ +P + E +E E VL + +++ I ++I S +CK II ++GAGIS +AGIPDFRSP+T
Sbjct: 216 IVAPSEQEESEEDESCVLKKPTIEEIAKYINSAKCKNIIVMTGAGISVAAGIPDFRSPKT 275
Query: 413 GLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLL 592
GLY L KY+LP +AIF+I +F++NPKPF+ L+KELFPGSF PT HYFI+LL +KGLL
Sbjct: 276 GLYEKLDKYDLPYREAIFDIEYFKKNPKPFYVLSKELFPGSFNPTTVHYFIKLLSDKGLL 335
Query: 593 LRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
LR++TQNIDTLER AGIP KLVEAHG+F TSHC+
Sbjct: 336 LRNFTQNIDTLERIAGIPANKLVEAHGSFATSHCV 370
>UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p; n=6;
Pezizomycotina|Rep: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p -
Aspergillus niger
Length = 378
Score = 199 bits (486), Expect = 5e-50
Identities = 82/143 (57%), Positives = 117/143 (81%)
Frame = +2
Query: 272 PEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQ 451
P VL+ +++ I +++K K+++ + GAGISTSAGIPDFRSP+TG+Y NL +LP
Sbjct: 14 PPSVLEARTIEAIAKYVKQKPVKRVVVMVGAGISTSAGIPDFRSPDTGIYSNLAHLDLPD 73
Query: 452 PQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLER 631
P+A+F+I+FFRQNP+PF+ LA+EL PG F+PTI+H FI+LL++KG+LL+H++QNID LER
Sbjct: 74 PEAVFDISFFRQNPRPFYALARELAPGQFRPTIAHSFIKLLYDKGMLLKHFSQNIDCLER 133
Query: 632 GAGIPEEKLVEAHGTFYTSHCLD 700
AG+P +K+VEAHG+F T HC+D
Sbjct: 134 LAGVPGDKIVEAHGSFATQHCID 156
>UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3,
mitochondrial precursor; n=22; Euteleostomi|Rep:
NAD-dependent deacetylase sirtuin-3, mitochondrial
precursor - Homo sapiens (Human)
Length = 399
Score = 196 bits (477), Expect = 6e-49
Identities = 85/135 (62%), Positives = 111/135 (82%)
Frame = +2
Query: 290 EVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFE 469
++SL + I++ C++++ + GAGIST +GIPDFRSP +GLY NLQ+Y+LP P+AIFE
Sbjct: 122 KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFE 181
Query: 470 INFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPE 649
+ FF NPKPFFTLAKEL+PG++KP ++HYF+RLLH+KGLLLR YTQNID LER +GIP
Sbjct: 182 LPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPA 241
Query: 650 EKLVEAHGTFYTSHC 694
KLVEAHGTF ++ C
Sbjct: 242 SKLVEAHGTFASATC 256
>UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putative;
n=3; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Neosartorya fischeri (strain
ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 425
Score = 194 bits (473), Expect = 2e-48
Identities = 80/140 (57%), Positives = 116/140 (82%)
Frame = +2
Query: 281 VLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQA 460
VL+ +++ + ++IK ++I+ + GAGISTSAGIPDFRSP+TGLY NL +LP+P+
Sbjct: 17 VLEVRNIESVAKYIKEKDVRRIVVMVGAGISTSAGIPDFRSPDTGLYSNLAFLDLPEPED 76
Query: 461 IFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAG 640
+F+I++FR+NP+PF+ LA+EL PG ++PTI+H F++LLH+KGLLL+H+TQNID LER AG
Sbjct: 77 VFDISYFRENPRPFYALARELAPGRYRPTIAHSFVKLLHDKGLLLKHFTQNIDCLERLAG 136
Query: 641 IPEEKLVEAHGTFYTSHCLD 700
+P EK+VEAHG+F + HC+D
Sbjct: 137 VPGEKIVEAHGSFASQHCID 156
>UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information
regulation 2 homolog) 3; n=3; Xenopus|Rep: Sirtuin
(Silent mating type information regulation 2 homolog) 3
- Xenopus tropicalis (Western clawed frog) (Silurana
tropicalis)
Length = 401
Score = 191 bits (465), Expect = 2e-47
Identities = 85/133 (63%), Positives = 108/133 (81%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
+L+ I+ I + C II ++GAGIST++GIPDFR+P +GLY NLQKY++P P+AIF+IN
Sbjct: 113 NLEDILDLITKNCCTNIIVMAGAGISTASGIPDFRTPGSGLYDNLQKYDIPYPEAIFDIN 172
Query: 476 FFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
+F NP PFF LAKELFPG +KP + HYFI+LLH+KGLLLR YTQNID LER AGIP EK
Sbjct: 173 YFVCNPNPFFHLAKELFPGKYKPNLVHYFIKLLHDKGLLLRCYTQNIDGLERLAGIPVEK 232
Query: 656 LVEAHGTFYTSHC 694
+VE HGTF+++ C
Sbjct: 233 IVEVHGTFFSASC 245
>UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 446
Score = 190 bits (463), Expect = 3e-47
Identities = 85/153 (55%), Positives = 114/153 (74%)
Frame = +2
Query: 242 SPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLY 421
S + P +PP L S++G+ +IK+ + K I+ L+GAGISTSAGIPDFRSPETG+Y
Sbjct: 6 SHAQINPDDPPH-TLPARSIEGVAEFIKNGQAKNIVVLTGAGISTSAGIPDFRSPETGIY 64
Query: 422 HNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRH 601
NL + +LP +A+F+I+FFR+NP PF+ LAKEL+PG F PTISH F+ L+ +KGLL
Sbjct: 65 ANLAELDLPYAEAVFDIDFFRENPAPFYVLAKELYPGQFYPTISHAFVALIEKKGLLRML 124
Query: 602 YTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
+TQNID LER AG+ EK++EAHG+F T C+D
Sbjct: 125 FTQNIDCLERRAGVSSEKVIEAHGSFATQRCID 157
>UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 446
Score = 190 bits (462), Expect = 4e-47
Identities = 84/153 (54%), Positives = 113/153 (73%)
Frame = +2
Query: 242 SPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLY 421
S + P +PP L S++G+ +IKS + K I+ ++GAGISTSAGIPDFRSPETG+Y
Sbjct: 6 SQPQINPNDPPH-TLSARSIEGVADFIKSGKAKNIVVMTGAGISTSAGIPDFRSPETGIY 64
Query: 422 HNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRH 601
NL + LP +A+F+I+FFR+NP PF+ LAKEL+PG F PT+SH F+ L+ +KGLL
Sbjct: 65 ANLAELNLPYAEAVFDIDFFRENPAPFYVLAKELYPGQFYPTVSHAFVALIEKKGLLRML 124
Query: 602 YTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
+TQNID LER AG+ EK++EAHG+F T C+D
Sbjct: 125 FTQNIDCLERRAGVSSEKVIEAHGSFATQRCID 157
>UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 460
Score = 190 bits (462), Expect = 4e-47
Identities = 85/148 (57%), Positives = 116/148 (78%)
Frame = +2
Query: 257 EPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQK 436
EPA P + L+ +L+ + IKS + K+I ++GAGIST+AGIPDFRSP TGLY NL++
Sbjct: 15 EPAAP--QTLESRTLEAVADHIKSGKVKRITVMTGAGISTAAGIPDFRSPGTGLYSNLER 72
Query: 437 YELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNI 616
+LP+P+A+F+I+FFR P+PF+ LAKEL+PG F+PTISH FI LL +KGLL ++TQNI
Sbjct: 73 LKLPEPEAVFDISFFRDRPEPFYVLAKELYPGKFQPTISHAFIALLSKKGLLQMNFTQNI 132
Query: 617 DTLERGAGIPEEKLVEAHGTFYTSHCLD 700
D LER AG+P EK++EAHG+F T C++
Sbjct: 133 DCLERQAGVPGEKVIEAHGSFATQSCIE 160
>UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2;
Ostreococcus|Rep: NAD-dependent deacetylase SIRT2 -
Ostreococcus tauri
Length = 394
Score = 185 bits (450), Expect = 1e-45
Identities = 80/141 (56%), Positives = 109/141 (77%)
Frame = +2
Query: 275 EKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQP 454
+K L+ L G+ ++KS R K ++ ++GAGIS SAGIPDFRS E+GLY L +Y+LP P
Sbjct: 83 DKALESFDLAGVASYVKSGRAKNVVVMTGAGISVSAGIPDFRS-ESGLYARLGEYDLPYP 141
Query: 455 QAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERG 634
QA+FE+ +F+ P PF+ LAKEL+PG+F PT +HYFI+LLH+KG+L R +TQNID+LER
Sbjct: 142 QAVFELGYFKDRPGPFYRLAKELYPGAFAPTPTHYFIKLLHDKGILRRCFTQNIDSLERA 201
Query: 635 AGIPEEKLVEAHGTFYTSHCL 697
G+P+EK+V AHG F +HCL
Sbjct: 202 TGLPKEKVVPAHGNFDGAHCL 222
>UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 304
Score = 184 bits (447), Expect = 2e-45
Identities = 81/142 (57%), Positives = 106/142 (74%)
Frame = +2
Query: 275 EKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQP 454
++ L +DG+V +IKS + KKII L+GAGIST+AGIPDFRS TG Y NLQKY LP+P
Sbjct: 4 DRKLKSFDMDGVVDYIKSGKAKKIIFLTGAGISTAAGIPDFRSIGTGFYSNLQKYNLPEP 63
Query: 455 QAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERG 634
+F I +F++N +PF+ L L PG +KPT HYF + +KG+LL+ YTQNID LER
Sbjct: 64 SDVFNIKYFKENQEPFYDLCPSLLPGKYKPTFIHYFGAYMAKKGILLKQYTQNIDGLERI 123
Query: 635 AGIPEEKLVEAHGTFYTSHCLD 700
AG+PE+KLVE+HGTF T+HC +
Sbjct: 124 AGVPEDKLVESHGTFSTAHCTE 145
>UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU00523.1;
n=2; Pezizomycotina|Rep: Putative uncharacterized protein
NCU00523.1 - Neurospora crassa
Length = 1220
Score = 183 bits (446), Expect = 3e-45
Identities = 83/143 (58%), Positives = 108/143 (75%)
Frame = +2
Query: 272 PEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQ 451
PE L E SL + +IKS + +K++ L+GAGIST+AGIPDFRSPETGLY NL EL +
Sbjct: 857 PEN-LSERSLPAVADYIKSGKARKVVVLTGAGISTAAGIPDFRSPETGLYANLAALELEE 915
Query: 452 PQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLER 631
P+ +F + FF++NPKPF+ LAK+L+PG F PTISH FI LL KGLL + +TQNID LER
Sbjct: 916 PEDVFSLPFFKENPKPFYVLAKDLYPGKFHPTISHVFISLLATKGLLYQLFTQNIDCLER 975
Query: 632 GAGIPEEKLVEAHGTFYTSHCLD 700
AG+P + +VEAHG+F + C+D
Sbjct: 976 AAGVPADLIVEAHGSFASQRCID 998
>UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome
shotgun sequence; n=6; Clupeocephala|Rep: Chromosome 13
SCAF14715, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 327
Score = 182 bits (444), Expect = 6e-45
Identities = 78/132 (59%), Positives = 104/132 (78%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
L + R +K RC+ ++ ++GAGIST++GIPDFR+P TGLY NL++Y+LP P+A+F I++
Sbjct: 36 LASVARLVKLGRCRNVVVVAGAGISTASGIPDFRTPGTGLYANLEQYKLPYPEAVFSIDY 95
Query: 479 FRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKL 658
F +P PFF+LAK L+PG +P HYF+R+LH KGLLLR YTQNID LER GIPE+KL
Sbjct: 96 FSDDPLPFFSLAKALYPGHHRPNYIHYFVRMLHHKGLLLRVYTQNIDGLERLCGIPEDKL 155
Query: 659 VEAHGTFYTSHC 694
VEAHG+F T+ C
Sbjct: 156 VEAHGSFRTASC 167
>UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n=1;
Schizosaccharomyces pombe|Rep: Sir2 family histone
deacetylase Hst2 - Schizosaccharomyces pombe (Fission
yeast)
Length = 332
Score = 181 bits (440), Expect = 2e-44
Identities = 77/134 (57%), Positives = 107/134 (79%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
L+ + IK + KKI + GAGIST+AGIPDFRSPETG+Y+NLQ++ LP +A+F++++
Sbjct: 15 LEKVASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSY 74
Query: 479 FRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKL 658
FR+NP+PF+ LA EL P ++PT +HYFIRLLH+K LL + YTQNIDTLER AG+P++ L
Sbjct: 75 FRKNPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKAL 134
Query: 659 VEAHGTFYTSHCLD 700
+EAHG+F S C++
Sbjct: 135 IEAHGSFQYSRCIE 148
>UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 523
Score = 180 bits (438), Expect = 3e-44
Identities = 83/134 (61%), Positives = 101/134 (75%), Gaps = 1/134 (0%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
S+ + I S + II ++GAGIST +GIPDFR+P TGLY NL KY++P P A+F+ +
Sbjct: 106 SIKDVAELISSGGVRNIIVMAGAGISTGSGIPDFRTPGTGLYDNLHKYKIPAPTAVFDRD 165
Query: 476 FFRQNPKPFFTLAKELFP-GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEE 652
+F NPKPFF LAKEL+P G ++P I HYF+R LHEKGLLLR YTQNID LER AGIP
Sbjct: 166 YFNVNPKPFFELAKELYPSGKYRPNIVHYFVRCLHEKGLLLRMYTQNIDGLERLAGIPPS 225
Query: 653 KLVEAHGTFYTSHC 694
KLVEAHGTF T+ C
Sbjct: 226 KLVEAHGTFSTASC 239
>UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 387
Score = 180 bits (437), Expect = 4e-44
Identities = 79/146 (54%), Positives = 112/146 (76%), Gaps = 1/146 (0%)
Frame = +2
Query: 266 EPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYEL 445
+ P L E SL + +IKS + ++I+ ++GAGIST+AGIPDFRSP TGLY NL L
Sbjct: 11 DTPPLTLRERSLTAVADFIKSGQARRIVVMTGAGISTAAGIPDFRSPTTGLYANLSALNL 70
Query: 446 PQPQAIFEINFFRQNPKPFFTLAKELFPGS-FKPTISHYFIRLLHEKGLLLRHYTQNIDT 622
P+P+A+F+++FFRQNP+PF+ LA+EL+PG+ ++PTISH F+ LL +GLL +TQNID
Sbjct: 71 PEPEAVFDLSFFRQNPQPFYVLARELYPGARYRPTISHAFLALLARRGLLHMLFTQNIDC 130
Query: 623 LERGAGIPEEKLVEAHGTFYTSHCLD 700
LER AG+P +++VEAHG+F + C+D
Sbjct: 131 LERAAGVPADRIVEAHGSFASQRCVD 156
>UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=8;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-3 -
Mus musculus (Mouse)
Length = 257
Score = 178 bits (434), Expect = 9e-44
Identities = 78/112 (69%), Positives = 94/112 (83%)
Frame = +2
Query: 359 GAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSF 538
GAGIST +GIPDFRSP +GLY NLQ+Y++P P+AIFE+ FF NPKPFF LAKEL+PG +
Sbjct: 3 GAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHY 62
Query: 539 KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+P ++HYF+RLLH+K LLLR YTQNID LER +GIP KLVEAHGTF T+ C
Sbjct: 63 RPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATC 114
>UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 335
Score = 172 bits (418), Expect = 8e-42
Identities = 74/115 (64%), Positives = 95/115 (82%)
Frame = +2
Query: 353 LSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPG 532
++GAGIST +GIPDFR+P TGLY NLQ+Y +P+P AIF+I +F +P+PFF LAK L+PG
Sbjct: 1 MAGAGISTPSGIPDFRTPGTGLYDNLQEYNIPEPTAIFDIEYFWYDPRPFFCLAKTLYPG 60
Query: 533 SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+++P HYF++LLH+KG LLR YTQNID LER AG+P EKLVEAHGTF T+ C+
Sbjct: 61 NYQPNYVHYFVKLLHDKGFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCI 115
>UniRef50_Q750H1 Cluster: AGL018Cp; n=1; Eremothecium gossypii|Rep:
AGL018Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 340
Score = 172 bits (418), Expect = 8e-42
Identities = 73/135 (54%), Positives = 104/135 (77%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
S++ + ++IK+ K++ L GAGISTS GIPDFRSP TGLYHNL K++LP +A+F I+
Sbjct: 8 SINKVAKYIKNHPKAKVVFLVGAGISTSCGIPDFRSPNTGLYHNLSKFKLPYAEAVFAID 67
Query: 476 FFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
+F+++PKPF+TLA+E++PG + P+ HY ++L KG L YTQNIDTLER AGI +
Sbjct: 68 YFQRDPKPFYTLAREMYPGKYIPSRFHYLMKLFESKGYLKAVYTQNIDTLEREAGIAADY 127
Query: 656 LVEAHGTFYTSHCLD 700
++EAHG+F T+HC+D
Sbjct: 128 IIEAHGSFATNHCID 142
>UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase,
putative; n=2; Filobasidiella neoformans|Rep:
NAD-dependent histone deacetylase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 413
Score = 172 bits (418), Expect = 8e-42
Identities = 78/127 (61%), Positives = 98/127 (77%)
Frame = +2
Query: 317 WIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK 496
+IKS K +I L GAGISTSAGIPDFRSP TGLYHNLQ ELP P+A+FE+ FF++ P+
Sbjct: 66 FIKSGNAKDVIFLLGAGISTSAGIPDFRSPSTGLYHNLQALELPFPEAVFELGFFQRRPE 125
Query: 497 PFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGT 676
PF+TLAKE++PG PT +HY ++L + LL R +TQNIDTLE AG+P +VEAHG+
Sbjct: 126 PFWTLAKEIYPGRHFPTPTHYLLQLFNRHNLLKRVFTQNIDTLETLAGLPPHLIVEAHGS 185
Query: 677 FYTSHCL 697
F T+HCL
Sbjct: 186 FATAHCL 192
>UniRef50_P53686 Cluster: NAD-dependent deacetylase HST2; n=4;
Saccharomyces cerevisiae|Rep: NAD-dependent deacetylase
HST2 - Saccharomyces cerevisiae (Baker's yeast)
Length = 357
Score = 171 bits (415), Expect = 2e-41
Identities = 74/136 (54%), Positives = 105/136 (77%)
Frame = +2
Query: 290 EVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFE 469
E+S+ I +KS+ K+I + GAGISTS GIPDFRSP TGLYHNL + +LP P+A+F+
Sbjct: 9 EMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFD 68
Query: 470 INFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPE 649
++FF+ +P PF+TLAKEL+PG+F+P+ HY ++L +K +L R YTQNIDTLER AG+ +
Sbjct: 69 VDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKD 128
Query: 650 EKLVEAHGTFYTSHCL 697
+ ++EAHG+F HC+
Sbjct: 129 DLIIEAHGSFAHCHCI 144
>UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces
cerevisiae YPL015c; n=3; Saccharomycetales|Rep: Similar
to sp|P53686 Saccharomyces cerevisiae YPL015c - Candida
glabrata (Yeast) (Torulopsis glabrata)
Length = 364
Score = 170 bits (414), Expect = 2e-41
Identities = 74/130 (56%), Positives = 101/130 (77%)
Frame = +2
Query: 308 IVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQ 487
+ +K K+I L GAGISTS+GIPDFRSP+TGLYHNL K +LP +A+F+I ++++
Sbjct: 7 VAEHLKKYPSSKVIFLVGAGISTSSGIPDFRSPKTGLYHNLSKLKLPYAEAVFDIEYYQE 66
Query: 488 NPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEA 667
NP+PF+ LA EL+PG+FKP+ HY +++L + G L R YTQNIDTLER AGIP++ LVEA
Sbjct: 67 NPQPFYLLADELYPGNFKPSKFHYLMKVLEKNGRLRRVYTQNIDTLEREAGIPDDYLVEA 126
Query: 668 HGTFYTSHCL 697
HG+F +HC+
Sbjct: 127 HGSFAKNHCI 136
>UniRef50_O94066 Cluster: Transcription regulatory protein; n=6;
Saccharomycetales|Rep: Transcription regulatory protein
- Candida albicans (Yeast)
Length = 331
Score = 170 bits (413), Expect = 3e-41
Identities = 78/137 (56%), Positives = 107/137 (78%), Gaps = 2/137 (1%)
Frame = +2
Query: 296 SLDGIVRWIKS--DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFE 469
SLD I++ + KK+ +GAGIST AGIPDFRSP+TGLY NL K LP +A+F+
Sbjct: 3 SLDDILKPVAEAVKNGKKVTFFNGAGISTGAGIPDFRSPDTGLYANLAKLNLPFAEAVFD 62
Query: 470 INFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPE 649
I+FF+++PKPF+TLA+EL+PG+F PT H+FI+LL ++G L R YTQNIDTLER AG+ +
Sbjct: 63 IDFFKEDPKPFYTLAEELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVED 122
Query: 650 EKLVEAHGTFYTSHCLD 700
+ +VEAHG+F ++HC+D
Sbjct: 123 KYIVEAHGSFASNHCVD 139
>UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Zn finger-containing
protein - Dictyostelium discoideum AX4
Length = 456
Score = 169 bits (412), Expect = 4e-41
Identities = 78/131 (59%), Positives = 106/131 (80%), Gaps = 3/131 (2%)
Frame = +2
Query: 311 VRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHN--LQKYELPQPQAIFEINFFR 484
++ IK+D+CK II L+GAGIS ++GIPDFRS ETGLY+N + K++LP +A+F+I++F+
Sbjct: 172 IKLIKNDKCKNIIVLTGAGISVASGIPDFRSVETGLYNNENVSKFKLPFKEAVFDIDYFK 231
Query: 485 QNPKPFFTLAKELFP-GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLV 661
NP+PF+ L+K+L+P G FK T HYFI+LL +KGLLLR+Y QN DTLER AGIP +KL+
Sbjct: 232 FNPEPFYQLSKDLYPSGKFKCTPVHYFIKLLSDKGLLLRNYAQNADTLERIAGIPLDKLI 291
Query: 662 EAHGTFYTSHC 694
EAHG+F S C
Sbjct: 292 EAHGSFAVSRC 302
>UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 383
Score = 167 bits (405), Expect = 3e-40
Identities = 74/133 (55%), Positives = 101/133 (75%), Gaps = 2/133 (1%)
Frame = +2
Query: 305 GIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFR 484
G+ ++I+ + K II L GAG+ST+AGIPDFRSP TGLY NLQKY LP P+A+F++N+F
Sbjct: 124 GVAKYIRKNHVKNIIALVGAGMSTTAGIPDFRSPRTGLYFNLQKYNLPYPEAVFDMNYFP 183
Query: 485 QNPKPFFTLAKELFP--GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKL 658
NP PF+ + K +FP G++ PT H F++LL++KG+L YTQNID LE AGIP +K+
Sbjct: 184 SNPAPFYEVMKVMFPGQGTYFPTKCHRFLKLLNDKGILKMVYTQNIDGLESVAGIPNDKV 243
Query: 659 VEAHGTFYTSHCL 697
+ +HGTF +SHCL
Sbjct: 244 ICSHGTFRSSHCL 256
>UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 534
Score = 166 bits (404), Expect = 4e-40
Identities = 78/137 (56%), Positives = 102/137 (74%), Gaps = 2/137 (1%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKK--IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFE 469
+LD I R+I ++ II L+GAGISTSAGIPDFRSP+TGLY NL ++ L P +F+
Sbjct: 20 TLDQIARYILANPGSPPGIIILAGAGISTSAGIPDFRSPKTGLYDNLARFSLDSPTDVFD 79
Query: 470 INFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPE 649
INFFR NP+PF++LA EL+PG + PTISH F+ LL KGLL +TQNID LE+ AG+P
Sbjct: 80 INFFRTNPQPFYSLAPELYPGRYAPTISHAFVALLARKGLLAMLFTQNIDGLEKAAGVPP 139
Query: 650 EKLVEAHGTFYTSHCLD 700
+ +VEAHG+F + C+D
Sbjct: 140 DLVVEAHGSFDSQRCID 156
>UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 434
Score = 165 bits (400), Expect = 1e-39
Identities = 76/136 (55%), Positives = 101/136 (74%), Gaps = 2/136 (1%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAG--IPDFRSPETGLYHNLQKYELPQPQAIFE 469
+L G+ + S + +I L+GAGISTSA IPDFRSP TGLY NL Y LP +AIF+
Sbjct: 35 TLSGVASLLASPTTRNVIVLAGAGISTSASPPIPDFRSPGTGLYANLAAYNLPYAEAIFD 94
Query: 470 INFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPE 649
I +F+++P+PFFTLAK L+PG+FKP ++HYF+ LL K L R +TQN+DTLER AG+
Sbjct: 95 IGYFQRHPQPFFTLAKHLYPGNFKPALAHYFLTLLQRKQKLKRVFTQNVDTLERIAGVEA 154
Query: 650 EKLVEAHGTFYTSHCL 697
+K+VEAHG+F TS C+
Sbjct: 155 DKVVEAHGSFATSTCI 170
>UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 403
Score = 160 bits (389), Expect = 3e-38
Identities = 73/132 (55%), Positives = 95/132 (71%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
++ I IKS + KI+ L GAGIST+AGIPDFRSPETG+Y L+ LP P+AIF IN+
Sbjct: 80 IENIANLIKSGQVHKIVVLVGAGISTAAGIPDFRSPETGIYDRLKPLHLPYPEAIFHINY 139
Query: 479 FRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKL 658
FR P+PF+ +A+ P S KPTI+H F+ LL +KGLL +TQNID LER GIPE+K+
Sbjct: 140 FRHTPEPFYAIARARHPRSLKPTITHAFLALLEKKGLLHFVFTQNIDGLERDVGIPEDKI 199
Query: 659 VEAHGTFYTSHC 694
+ AHG++ T C
Sbjct: 200 LNAHGSWRTQRC 211
>UniRef50_UPI00005A356B Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin-3, mitochondrial precursor
(SIR2-like protein 3) (hSIRT3) isoform 1; n=2; Canis
lupus familiaris|Rep: PREDICTED: similar to
NAD-dependent deacetylase sirtuin-3, mitochondrial
precursor (SIR2-like protein 3) (hSIRT3) isoform 1 -
Canis familiaris
Length = 248
Score = 159 bits (387), Expect = 5e-38
Identities = 70/112 (62%), Positives = 90/112 (80%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
L I I++ C++++ + GAGIST +GIPDFRSP +GLY NLQ+Y+LP P+A+FE+ F
Sbjct: 98 LQDIAELIRARACQRVLVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAVFELAF 157
Query: 479 FRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERG 634
F NPKPFFTLAKEL+ +++P I HYF+RLLH+KGLLLR YTQNID LERG
Sbjct: 158 FSHNPKPFFTLAKELYLKNYRPNIIHYFLRLLHDKGLLLRLYTQNIDGLERG 209
>UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 312
Score = 159 bits (386), Expect = 6e-38
Identities = 72/144 (50%), Positives = 100/144 (69%)
Frame = +2
Query: 263 AEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYE 442
A P K L+E + DG+V++IKS + L+GAG S ++GIPDFR+P+ GLY NL KY+
Sbjct: 9 APPLVKGLEEATFDGLVKYIKSGHATNTVFLTGAGTSVASGIPDFRTPKIGLYANLDKYK 68
Query: 443 LPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDT 622
LP P+A+F+I FF NP PFF + + + PG+FKP+ +HY L + LL R YTQNID+
Sbjct: 69 LPYPEAVFDIEFFDTNPGPFFDVCRNILPGTFKPSPAHYLPVLFDKHKLLTRLYTQNIDS 128
Query: 623 LERGAGIPEEKLVEAHGTFYTSHC 694
L+ AG+P +K+VEAHG+F C
Sbjct: 129 LDISAGLPLDKIVEAHGSFTYLTC 152
>UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 320
Score = 159 bits (385), Expect = 8e-38
Identities = 70/139 (50%), Positives = 97/139 (69%)
Frame = +2
Query: 278 KVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQ 457
K L + LDGIV +I KKI+ SGAG S ++GIPDFRSP+ GLY L+KY LP+P+
Sbjct: 17 KGLSSLDLDGIVSFINEGNAKKILIFSGAGTSVASGIPDFRSPKIGLYSQLKKYNLPRPE 76
Query: 458 AIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGA 637
+IF ++F+ +P+PFF+L K PG +KP+ +H+ +L G+LLRHY+QNID L++ A
Sbjct: 77 SIFTRDYFKYHPEPFFSLIKFFLPGKYKPSPAHFLAKLFENHGILLRHYSQNIDGLDKAA 136
Query: 638 GIPEEKLVEAHGTFYTSHC 694
G+ EE LVE HGT + C
Sbjct: 137 GLSEEHLVEWHGTLSKATC 155
>UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional
regulator; n=2; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 346
Score = 157 bits (381), Expect = 2e-37
Identities = 75/154 (48%), Positives = 103/154 (66%), Gaps = 8/154 (5%)
Frame = +2
Query: 260 PAEPPEKVLDEVSL------DGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLY 421
P E +K+ D + L G ++K + ++ ++GAGISTSAGIPDFR+P TGLY
Sbjct: 71 PKEKVQKLYDTLPLFLPKNAKGFGLFMKYRKPSNVVVMAGAGISTSAGIPDFRTPGTGLY 130
Query: 422 HNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFP--GSFKPTISHYFIRLLHEKGLLL 595
NL+ Y LP P A+F+IN+F+ NPKPF+T+A EL P G + PT +HYF+ L++ G +
Sbjct: 131 DNLEAYNLPFPTAVFDINYFKSNPKPFYTIASELMPGLGKYFPTPTHYFLTYLNKLGYIS 190
Query: 596 RHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+TQNID LE +G P EKLV AHG +Y+ HCL
Sbjct: 191 MLFTQNIDGLEIQSGFPNEKLVMAHGNYYSGHCL 224
>UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putative;
n=2; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 329
Score = 156 bits (378), Expect = 6e-37
Identities = 70/132 (53%), Positives = 95/132 (71%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
++ I IKS + ++I+ L GAGIST+AGIPDFRSPETG+Y L+ LP P+AIF IN+
Sbjct: 4 IEKIATLIKSGQIRRIVVLVGAGISTAAGIPDFRSPETGIYDRLKPLGLPYPEAIFHINY 63
Query: 479 FRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKL 658
FR P+PF+ +A+ P + KPTI+H F+ LL +K LL +TQNID LER G+PE K+
Sbjct: 64 FRHTPEPFYAIARARHPRTLKPTITHAFLALLAKKNLLHFLFTQNIDGLERDTGVPENKI 123
Query: 659 VEAHGTFYTSHC 694
+ AHG++ T HC
Sbjct: 124 LNAHGSWRTQHC 135
>UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 306
Score = 153 bits (370), Expect = 5e-36
Identities = 76/143 (53%), Positives = 105/143 (73%), Gaps = 2/143 (1%)
Frame = +2
Query: 275 EKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KY-ELP 448
+K+ + +LD +VR IK +CK II L+GAG+S S GIPDFRS + G+Y L +Y +LP
Sbjct: 51 QKLPNVNTLDDVVRLIK--KCKNIIVLTGAGVSVSCGIPDFRSRD-GIYAKLSVEYPDLP 107
Query: 449 QPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
PQA+F+I +F QNPKPFF AKE++PG FKP++ H FI L E G LLR+Y+QNIDTLE
Sbjct: 108 DPQAMFDITYFNQNPKPFFKFAKEIYPGQFKPSLCHRFIHQLEEHGHLLRNYSQNIDTLE 167
Query: 629 RGAGIPEEKLVEAHGTFYTSHCL 697
+ AGI ++++ HG+F T+ C+
Sbjct: 168 QVAGI--TRVIQCHGSFSTASCM 188
>UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 542
Score = 151 bits (367), Expect = 1e-35
Identities = 69/121 (57%), Positives = 93/121 (76%), Gaps = 1/121 (0%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQK-YELPQPQAIFEINFFRQNPKPFFTLA 514
K I+ ++GAG+S S GIPDFRS + G+Y ++K Y LP+P+++F+I++ R NP PFF A
Sbjct: 301 KNIVIITGAGVSVSCGIPDFRS-KGGVYETIEKKYNLPRPESLFDIHYLRANPLPFFEFA 359
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
KE+FPG+ KP+ +H FI+LL EKG LLR+YTQNIDTLE AGI EKLV HG+F T+ C
Sbjct: 360 KEIFPGNHKPSPTHSFIKLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSFSTATC 419
Query: 695 L 697
+
Sbjct: 420 I 420
>UniRef50_Q4DP02 Cluster: Silent information regulator 2, putative;
n=4; Trypanosoma|Rep: Silent information regulator 2,
putative - Trypanosoma cruzi
Length = 359
Score = 145 bits (352), Expect = 8e-34
Identities = 68/142 (47%), Positives = 97/142 (68%), Gaps = 2/142 (1%)
Frame = +2
Query: 281 VLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQA 460
V+ E + + + R+I+ + KI+ ++GAGIS +AGIPDFRSP TG+Y L KY L P
Sbjct: 11 VVGEPTFEALARYIERNNVTKILVMAGAGISVAAGIPDFRSPHTGIYARLGKYNLNSPTD 70
Query: 461 IFEINFFRQNPKPFFTLAKE--LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERG 634
F I R+ P F+++ +E L+PG F PT+ H+FI+LL ++G LLR TQNID LER
Sbjct: 71 AFSITLLRERPDVFYSIVREMDLWPGHFWPTLVHHFIKLLADEGRLLRCCTQNIDGLERA 130
Query: 635 AGIPEEKLVEAHGTFYTSHCLD 700
+G+P LVEAHG+F T+ C++
Sbjct: 131 SGLPMSFLVEAHGSFSTASCIE 152
>UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=29;
Euteleostomi|Rep: NAD-dependent deacetylase sirtuin-1 -
Homo sapiens (Human)
Length = 747
Score = 145 bits (352), Expect = 8e-34
Identities = 73/149 (48%), Positives = 108/149 (72%), Gaps = 4/149 (2%)
Frame = +2
Query: 263 AEPPE--KVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQK 436
+EPP+ K D +++ V+ ++ CKKII L+GAG+S S GIPDFRS + G+Y L
Sbjct: 229 SEPPKRKKRKDINTIEDAVKLLQE--CKKIIVLTGAGVSVSCGIPDFRSRD-GIYARLAV 285
Query: 437 Y--ELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQ 610
+LP PQA+F+I +FR++P+PFF AKE++PG F+P++ H FI L ++G LLR+YTQ
Sbjct: 286 DFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQ 345
Query: 611 NIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
NIDTLE+ AGI +++++ HG+F T+ CL
Sbjct: 346 NIDTLEQVAGI--QRIIQCHGSFATASCL 372
>UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=6; Leishmania|Rep: NAD-dependent deacetylase SIR2
homolog - Leishmania major
Length = 381
Score = 145 bits (352), Expect = 8e-34
Identities = 68/144 (47%), Positives = 98/144 (68%), Gaps = 2/144 (1%)
Frame = +2
Query: 275 EKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQP 454
E L E +++G+ R+I+ ++I+ L GAG S +AGIPDFRS +TG+Y L KY L P
Sbjct: 11 EHALGEPTVEGLARYIREKDVRRILVLVGAGASVAAGIPDFRSSDTGIYAKLGKYNLDDP 70
Query: 455 QAIFEINFFRQNPKPFFTLAKE--LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
F + R+ P+ F+++A+E L+PG F+PT H+FIRLL ++G LLR TQNID LE
Sbjct: 71 TDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLE 130
Query: 629 RGAGIPEEKLVEAHGTFYTSHCLD 700
+ AG+ E LVEAHG+F + C++
Sbjct: 131 KAAGVSPELLVEAHGSFAAAACIE 154
>UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1;
Filobasidiella neoformans|Rep: Histone deacetylase,
putative - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 596
Score = 145 bits (351), Expect = 1e-33
Identities = 74/144 (51%), Positives = 104/144 (72%), Gaps = 3/144 (2%)
Frame = +2
Query: 275 EKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ---KYEL 445
E++ D SLD V + + KKII LSGAGISTS GIPDFRS TGLY LQ KYEL
Sbjct: 138 ERLRDISSLDDAVSLLA--KSKKIIVLSGAGISTSCGIPDFRS-STGLYAQLQEEGKYEL 194
Query: 446 PQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTL 625
PQ +F+I +FR+ P+ F++ AK+++P +F P+ H +I++L ++G+LLR+YTQNIDTL
Sbjct: 195 DDPQQMFDIRYFREKPEVFYSFAKQIYPSNFVPSPCHRWIKMLEDRGVLLRNYTQNIDTL 254
Query: 626 ERGAGIPEEKLVEAHGTFYTSHCL 697
E AG+ E++++ HG+F T+ CL
Sbjct: 255 ESLAGV--ERVLQCHGSFKTASCL 276
>UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 737
Score = 144 bits (350), Expect = 1e-33
Identities = 77/148 (52%), Positives = 105/148 (70%), Gaps = 4/148 (2%)
Frame = +2
Query: 263 AEPPE-KVLDEVS-LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQK 436
+EP K LD V+ L +R IK+ KKI+ L+GAG+S S GIPDFRS + G+Y L
Sbjct: 164 SEPKRRKKLDTVNTLSDAIRLIKTS--KKILVLTGAGVSVSCGIPDFRSRD-GIYSRLSV 220
Query: 437 Y--ELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQ 610
+LP PQA+F+I++F+ +P+PFF AKE++PG FKP+ +H FI LL + G LLR+YTQ
Sbjct: 221 DFPDLPNPQAMFDIHYFKHDPRPFFKFAKEIYPGQFKPSRAHRFISLLEKTGRLLRNYTQ 280
Query: 611 NIDTLERGAGIPEEKLVEAHGTFYTSHC 694
NIDTLE+ AGI K+V+ HG+F T+ C
Sbjct: 281 NIDTLEQVAGI--SKVVQCHGSFATASC 306
>UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_152,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 449
Score = 144 bits (350), Expect = 1e-33
Identities = 62/139 (44%), Positives = 100/139 (71%), Gaps = 1/139 (0%)
Frame = +2
Query: 287 DEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIF 466
DE + +V +K+ + +++ L+GAG+S +AGIPDFR+P TGLY +QKY LP P+++F
Sbjct: 193 DEFTYAKLVDGLKNKKFQRVCVLAGAGMSVAAGIPDFRTPGTGLYSQIQKYNLPSPESVF 252
Query: 467 EINFFRQNPKPFFTLAKE-LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
EI +F++NP+ F+ +AKE L KPT++H F++ L +G LL+ +TQNID LE AG+
Sbjct: 253 EIEYFKKNPEAFYCVAKEFLLSFDAKPTLAHKFLKFLDSRGQLLKCFTQNIDGLELDAGV 312
Query: 644 PEEKLVEAHGTFYTSHCLD 700
++K+++AHG T+ C++
Sbjct: 313 SQDKVIQAHGHMRTARCIE 331
>UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA18743-PA - Nasonia vitripennis
Length = 871
Score = 144 bits (348), Expect = 2e-33
Identities = 74/148 (50%), Positives = 105/148 (70%), Gaps = 4/148 (2%)
Frame = +2
Query: 263 AEPP--EKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNL-Q 433
+EPP +K+ ++ +V IK+ K II L+GAG+S S GIPDFRS + G+Y L Q
Sbjct: 180 SEPPKRQKLTHVNTMSDVVELIKNS--KNIIVLTGAGVSVSCGIPDFRSRD-GIYSRLAQ 236
Query: 434 KY-ELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQ 610
+ +LP PQA+F+IN+F Q+P+PFF A+E++PG FKP+ H FI++L ++ LLR+Y+Q
Sbjct: 237 DFPDLPDPQAMFDINYFSQDPRPFFKFAREIYPGQFKPSPCHQFIKMLEKQKKLLRNYSQ 296
Query: 611 NIDTLERGAGIPEEKLVEAHGTFYTSHC 694
NIDTLER AGI L+E HG+F T+ C
Sbjct: 297 NIDTLERVAGI--NNLIECHGSFATASC 322
>UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 471
Score = 143 bits (346), Expect = 4e-33
Identities = 66/120 (55%), Positives = 89/120 (74%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
+I+ L+GAGIS SAGIPDFR+P +GLY LQKY+LP P+AIFEIN+F+ +P+PF+TL KE
Sbjct: 213 RIVFLTGAGISVSAGIPDFRTPGSGLYSQLQKYKLPYPEAIFEINYFKHHPQPFYTLCKE 272
Query: 521 LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
T SH+FI + + LL +++QNID LE AG+PE KLV+AHG F T+ C++
Sbjct: 273 FSSCGSHFTSSHFFIAETNRRNRLLINFSQNIDGLELEAGLPESKLVQAHGHFRTAKCVN 332
>UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG5216-PA - Tribolium castaneum
Length = 722
Score = 141 bits (341), Expect = 2e-32
Identities = 81/180 (45%), Positives = 116/180 (64%), Gaps = 6/180 (3%)
Frame = +2
Query: 173 RNMFRDL--DVDDVRMYLALKLGLFSPQDLEPAEPPE--KVLDEVSLDGIVRWIKSDRCK 340
R + DL D+D V Y+ ++ L+ AEPP K+ +LD +VR +K +
Sbjct: 156 RTLLSDLGVDLDQVPQYVD-EITLWKLIINMLAEPPRRNKLRHVNTLDDVVRLVKG--AQ 212
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNL--QKYELPQPQAIFEINFFRQNPKPFFTLA 514
II L+GAG+S S GIPDFRS + G+Y L +LP PQA+F+I++F Q+P+PFF A
Sbjct: 213 NIIVLTGAGVSVSCGIPDFRSRD-GIYVRLAIDFPDLPDPQAMFDISYFSQDPRPFFKFA 271
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
++++PG F P+ H FI++L G LLR+YTQNIDTLE+ A I EK++E HG+F T+ C
Sbjct: 272 RDIYPGKFTPSPCHRFIKMLENYGKLLRNYTQNIDTLEKVANI--EKVIECHGSFATATC 329
>UniRef50_Q5BVF7 Cluster: SJCHGC03105 protein; n=2; Schistosoma
japonicum|Rep: SJCHGC03105 protein - Schistosoma
japonicum (Blood fluke)
Length = 181
Score = 140 bits (340), Expect = 2e-32
Identities = 60/114 (52%), Positives = 86/114 (75%)
Frame = +2
Query: 269 PPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELP 448
PP+ L ++G+ + I+ + KI+T+ GAGIST+AGIPDFRSP +G+Y NL+++ LP
Sbjct: 41 PPK--LKSFDIEGVSQLIQDGKINKIVTMVGAGISTAAGIPDFRSPSSGVYDNLEEFNLP 98
Query: 449 QPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQ 610
P IF I +F+ +P+PFF +A+ L+ KPT++HYFI+LLH+KGLLLRHYTQ
Sbjct: 99 TPTTIFSIEYFQHDPRPFFEIARRLYRPEAKPTLAHYFIKLLHDKGLLLRHYTQ 152
>UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;
n=2; Pezizomycotina|Rep: NAD-dependent histone
deacetylase SIR2 - Aspergillus terreus (strain NIH 2624)
Length = 1068
Score = 140 bits (340), Expect = 2e-32
Identities = 66/134 (49%), Positives = 94/134 (70%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
S+D V+ ++ K I+ L+GAGISTS GIPDFRS +TGLY L+ L PQ +F+I+
Sbjct: 165 SIDDAVKLLQES--KNIVVLTGAGISTSLGIPDFRSKDTGLYSQLEHLGLSDPQEVFDIH 222
Query: 476 FFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
FR++P FF++AK++ P K + +H FIRLL +KG LL +YTQNID +E AG+ EK
Sbjct: 223 VFREDPSIFFSIAKDILPTEKKYSPTHGFIRLLQDKGKLLTNYTQNIDNIEANAGVVPEK 282
Query: 656 LVEAHGTFYTSHCL 697
+V+ HG+F T+ C+
Sbjct: 283 IVQCHGSFATATCV 296
>UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like
protein 1); n=1; Apis mellifera|Rep: PREDICTED: similar
to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2)
(SIR2-like protein 1) - Apis mellifera
Length = 868
Score = 140 bits (339), Expect = 3e-32
Identities = 72/148 (48%), Positives = 107/148 (72%), Gaps = 4/148 (2%)
Frame = +2
Query: 263 AEPP--EKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNL-Q 433
+EPP +K+ +L +VR I++ +II L+GAG+S S GIPDFRS + G+Y L Q
Sbjct: 179 SEPPRRQKLRHINTLTDVVRLIRNSN--RIIVLTGAGVSVSCGIPDFRSRD-GIYSRLAQ 235
Query: 434 KY-ELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQ 610
+ +LP PQA+F+IN+F Q+P+PF+ A+E++PG FKP+ H FI++L ++ LLR+Y+Q
Sbjct: 236 DFPDLPDPQAMFDINYFSQDPRPFYKFAREIYPGQFKPSPCHRFIKMLDKQKKLLRNYSQ 295
Query: 611 NIDTLERGAGIPEEKLVEAHGTFYTSHC 694
NIDTLE+ AGI E ++E HG+F T+ C
Sbjct: 296 NIDTLEQVAGI--ENVIECHGSFATASC 321
>UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_464_21655_23334 - Giardia lamblia
ATCC 50803
Length = 559
Score = 139 bits (336), Expect = 7e-32
Identities = 69/150 (46%), Positives = 99/150 (66%), Gaps = 1/150 (0%)
Frame = +2
Query: 254 LEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ 433
LE P +++ S + + ++ R +K+I L GAGIS SAGIPDFRS + G+Y+ LQ
Sbjct: 138 LEVKLPRKRITSCTSPEAFIYQLR--RARKVIFLVGAGISVSAGIPDFRS-KNGIYNRLQ 194
Query: 434 KYELPQPQAIFEINFFRQNPKPFFTLAKELFPG-SFKPTISHYFIRLLHEKGLLLRHYTQ 610
+Y L +P +F ++FFR NP PF+ E+FPG FKPT+ H F+RLL ++G L R YTQ
Sbjct: 195 QYNLQKPTDMFNLDFFRGNPIPFYRFCPEIFPGPQFKPTVVHLFMRLLEKRGQLQRIYTQ 254
Query: 611 NIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
NID LE A I ++ ++ HG+F+T C+D
Sbjct: 255 NIDCLEVQAQITQKYIINCHGSFHTFTCID 284
>UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein
NCU04737.1; n=3; Sordariomycetes|Rep: Putative
uncharacterized protein NCU04737.1 - Neurospora crassa
Length = 670
Score = 138 bits (334), Expect = 1e-31
Identities = 68/140 (48%), Positives = 96/140 (68%)
Frame = +2
Query: 278 KVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQ 457
K++ ++D V +K R K II L+GAGISTS GIPDFRS TGLY L+ L PQ
Sbjct: 189 KLMKYNTIDDAVELLK--RSKNIIVLTGAGISTSLGIPDFRSKGTGLYSKLEHLGLSDPQ 246
Query: 458 AIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGA 637
+F+IN FRQ+P F+++A+++ P + + + +H FI LL +KG LL +Y+QNID LE A
Sbjct: 247 EVFDINIFRQDPNIFYSVARDILPNTERFSPTHAFIALLQQKGKLLTNYSQNIDNLEAKA 306
Query: 638 GIPEEKLVEAHGTFYTSHCL 697
GI +KLV+ HG+F T+ C+
Sbjct: 307 GIHPDKLVQCHGSFATATCV 326
>UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 -
Drosophila melanogaster (Fruit fly)
Length = 823
Score = 136 bits (330), Expect = 4e-31
Identities = 67/137 (48%), Positives = 99/137 (72%), Gaps = 4/137 (2%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKY--ELPQPQAIFE 469
+ D ++ +K + +KII L+GAG+S S GIPDFRS G+Y L +LP PQA+F+
Sbjct: 208 TFDDVISLVK--KSQKIIVLTGAGVSVSCGIPDFRSTN-GIYARLAHDFPDLPDPQAMFD 264
Query: 470 INFFRQNPKPFFTLAKELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
IN+F+++P+PF+ A+E++PG F+P+ H FI++L KG LLR+YTQNIDTLER AGI
Sbjct: 265 INYFKRDPRPFYKFAREIYPGEFQFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI 324
Query: 644 PEEKLVEAHGTFYTSHC 694
++++E HG+F T+ C
Sbjct: 325 --QRVIECHGSFSTASC 339
>UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtuin 1
- Schistosoma mansoni (Blood fluke)
Length = 568
Score = 136 bits (328), Expect = 6e-31
Identities = 72/148 (48%), Positives = 103/148 (69%), Gaps = 4/148 (2%)
Frame = +2
Query: 263 AEP-PEKVLDEV-SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQK 436
AEP P + L + SL+ ++ + + C I+ ++GAGIS S GIPDFRS + G+Y L +
Sbjct: 130 AEPAPRRRLRRINSLEKVLSLLST--CTSILVITGAGISVSCGIPDFRSRD-GIYARLSR 186
Query: 437 -Y-ELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQ 610
Y +L PQA+F++++F++NP PFF AKELFPG F P+I+H I LL K LLR+YTQ
Sbjct: 187 DYPDLSSPQAMFDMSYFKRNPIPFFKFAKELFPGQFSPSITHRMIALLESKDKLLRNYTQ 246
Query: 611 NIDTLERGAGIPEEKLVEAHGTFYTSHC 694
NIDTLE+ AGI +L++ HG+F ++ C
Sbjct: 247 NIDTLEQAAGI--TRLIQCHGSFASATC 272
>UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18;
Pezizomycotina|Rep: Contig An01c0250, complete genome -
Aspergillus niger
Length = 495
Score = 136 bits (328), Expect = 6e-31
Identities = 64/134 (47%), Positives = 91/134 (67%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
++D V+ +K K I+ L+GAGISTS GIPDFRS +TGLY L L PQ +F+I
Sbjct: 167 TIDDAVKLLKES--KNIVVLTGAGISTSLGIPDFRSKDTGLYSQLAHLGLSDPQEVFDIQ 224
Query: 476 FFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
FR++P FF++AK++ P K + +H FIR+L +KG LL +YTQNID +E AG+ E
Sbjct: 225 VFREDPSIFFSIAKDILPTEKKFSPTHAFIRVLQDKGKLLTNYTQNIDNIEANAGVLPEN 284
Query: 656 LVEAHGTFYTSHCL 697
+V+ HG+F T+ C+
Sbjct: 285 IVQCHGSFATATCV 298
>UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=2; Caenorhabditis|Rep: NAD-dependent deacetylase SIR2
homolog - Caenorhabditis elegans
Length = 607
Score = 135 bits (326), Expect = 1e-30
Identities = 71/149 (47%), Positives = 97/149 (65%), Gaps = 2/149 (1%)
Frame = +2
Query: 254 LEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ 433
LE A +K+ + SL V K+ K I+ L+GAG+S S GIPDFRS + G+Y L+
Sbjct: 120 LERAPVRQKLTNYNSLADAVELFKTK--KHILVLTGAGVSVSCGIPDFRSKD-GIYARLR 176
Query: 434 KY--ELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYT 607
+LP P A+F+I +FR+NP PF+ A+E+FPG F P++SH FI+ L G LLR+YT
Sbjct: 177 SEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYT 236
Query: 608 QNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
QNIDTLE GI +++VE HG+F C
Sbjct: 237 QNIDTLEHQTGI--KRVVECHGSFSKCTC 263
>UniRef50_UPI0001555321 Cluster: PREDICTED: similar to sirtuin
(silent mating type information regulation 2 homolog) 3
(S. cerevisiae), partial; n=1; Ornithorhynchus
anatinus|Rep: PREDICTED: similar to sirtuin (silent
mating type information regulation 2 homolog) 3 (S.
cerevisiae), partial - Ornithorhynchus anatinus
Length = 148
Score = 132 bits (318), Expect = 1e-29
Identities = 57/89 (64%), Positives = 72/89 (80%)
Frame = +2
Query: 365 GISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKP 544
G +AG RSP +GLY NLQ+Y +P P+AIFE+ FF ++PKPFFTLAKEL+PG+++P
Sbjct: 60 GTEQAAGTRGLRSPGSGLYSNLQQYAIPYPEAIFELAFFHRDPKPFFTLAKELYPGNYRP 119
Query: 545 TISHYFIRLLHEKGLLLRHYTQNIDTLER 631
+HYF+RLLH+KGLLLR YTQNID LER
Sbjct: 120 NFAHYFLRLLHDKGLLLRLYTQNIDGLER 148
>UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;
Tetrahymena thermophila SB210|Rep: Chromatin regulatory
protein sir2 - Tetrahymena thermophila SB210
Length = 279
Score = 128 bits (310), Expect = 1e-28
Identities = 62/131 (47%), Positives = 89/131 (67%), Gaps = 1/131 (0%)
Frame = +2
Query: 311 VRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKY-ELPQPQAIFEINFFRQ 487
V ++K R KKII L+GAGIST+AGIPDFRS +TGLY L+K + P+ IF I++++Q
Sbjct: 22 VNFLKERRFKKIIVLTGAGISTNAGIPDFRSKDTGLYARLKKSGQFSYPEQIFTIDYYQQ 81
Query: 488 NPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEA 667
N KPF+ + +E ++P SH FI L ++ LL + TQNID LE AG+ ++ L++A
Sbjct: 82 NHKPFYEICREFVQKEYEPQQSHKFITELAKQNLLYLNITQNIDGLELKAGLDKKYLIQA 141
Query: 668 HGTFYTSHCLD 700
HG SHC++
Sbjct: 142 HGNLEKSHCIE 152
>UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 573
Score = 126 bits (305), Expect = 4e-28
Identities = 65/140 (46%), Positives = 89/140 (63%)
Frame = +2
Query: 278 KVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQ 457
K+ D ++ +V IK + KKI+ ++GAGISTS GIPDFRS + G Y LQ L PQ
Sbjct: 243 KLDDFYCVEHVVDQIK--KAKKILVVTGAGISTSLGIPDFRSSK-GFYSQLQYLGLSDPQ 299
Query: 458 AIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGA 637
+F+++FF +P F+ +A + P T H FI+LL KG LLR+YTQNID LE
Sbjct: 300 EVFDLDFFHSDPNIFYLIAYMILPPEKSYTPLHAFIKLLQNKGKLLRNYTQNIDNLESNV 359
Query: 638 GIPEEKLVEAHGTFYTSHCL 697
GI EKL++ HG+F T+ C+
Sbjct: 360 GIKPEKLIQCHGSFATASCV 379
>UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 596
Score = 126 bits (304), Expect = 5e-28
Identities = 62/124 (50%), Positives = 89/124 (71%), Gaps = 3/124 (2%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQ---KYELPQPQAIFEINFFRQNPKPFFT 508
K+I+ LSGAGIS S GIPDFRS + G+Y LQ +YEL PQ +F+ FF NP F++
Sbjct: 191 KRIMILSGAGISVSCGIPDFRSKD-GIYAILQSEGQYELDDPQDMFDKTFFLSNPSMFYS 249
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
A ++FP +F P+ +H FI+L+ E+G LLR+Y+QNIDTLE+ GI E++++ HG+F ++
Sbjct: 250 FAHKIFPSNFVPSSAHRFIKLIEERGQLLRNYSQNIDTLEQLVGI--ERVLQCHGSFASA 307
Query: 689 HCLD 700
C D
Sbjct: 308 SCTD 311
>UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 533
Score = 126 bits (303), Expect = 7e-28
Identities = 64/139 (46%), Positives = 91/139 (65%)
Frame = +2
Query: 278 KVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQ 457
K+ D ++D + IK+ KKII ++GAGISTS GIPDFRS GLY L+ L PQ
Sbjct: 190 KLPDYNTVDDAIVLIKN--AKKIIVITGAGISTSLGIPDFRSAN-GLYAQLEDTGLSDPQ 246
Query: 458 AIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGA 637
+F I+ FR++P FF +AK + P + + +H FI++L +KG LL +YTQNID +E A
Sbjct: 247 EVFNIDLFREDPTIFFQIAKNILPSVVRFSPTHQFIKVLQDKGKLLTNYTQNIDGIESAA 306
Query: 638 GIPEEKLVEAHGTFYTSHC 694
GI E +++ HG+F T+ C
Sbjct: 307 GILPENVIQCHGSFATATC 325
>UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 331
Score = 125 bits (301), Expect = 1e-27
Identities = 62/132 (46%), Positives = 84/132 (63%), Gaps = 5/132 (3%)
Frame = +2
Query: 320 IKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ---KYELPQPQAIFEINFFRQN 490
I S K +I L+GAGIST+AGIPDFRSP G+Y L+ + + P +F+I+ F +
Sbjct: 14 IISGNYKNVIVLTGAGISTAAGIPDFRSPAIGIYATLKSASRLKFRDPTFVFDIDVFMDD 73
Query: 491 PKPFFTLAKELFPGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVE 664
PKPF+ + L+P +PT HYFI L++ G+L R YTQN+D LE G+PE+KLV+
Sbjct: 74 PKPFWWIFSHLWPKDLWPRPTEMHYFIGYLNQLGVLKRVYTQNVDGLEIPGGLPEDKLVQ 133
Query: 665 AHGTFYTSHCLD 700
HG T HC D
Sbjct: 134 CHGALPTCHCCD 145
>UniRef50_Q7QZ37 Cluster: GLP_464_19573_21615; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_464_19573_21615 - Giardia lamblia
ATCC 50803
Length = 680
Score = 124 bits (300), Expect = 2e-27
Identities = 56/136 (41%), Positives = 93/136 (68%), Gaps = 2/136 (1%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
+L +V I + + I+ L+GAGIS +AGIPDFRS TGLY L++Y LP P ++F+++
Sbjct: 8 TLKRLVESISRAKKESIVILAGAGISVAAGIPDFRSKGTGLYSQLERYNLPTPTSMFDLS 67
Query: 476 FFRQNPKPFFTLAKELFPG-SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEE 652
++ P+PF +L+ +FP +KPT++H+F ++L ++GL+ YTQNID LE AG+
Sbjct: 68 YYCLRPRPFSSLSVSIFPSYKYKPTMAHHFFKILEDRGLVRFIYTQNIDELEIFAGVSPR 127
Query: 653 KLVEAHGTFYTS-HCL 697
++++ HG++ +CL
Sbjct: 128 RILQCHGSYCKGLYCL 143
>UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 1348
Score = 124 bits (298), Expect = 3e-27
Identities = 62/139 (44%), Positives = 90/139 (64%), Gaps = 2/139 (1%)
Frame = +2
Query: 284 LDEVSLD--GIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQ 457
++EV+L +V IK+ + I+ L+GAGISTS+GIPDFRSP GLY +QKY+L P+
Sbjct: 1 MEEVNLSYKEVVEKIKNKQINNILFLTGAGISTSSGIPDFRSPN-GLYSKVQKYKLEYPE 59
Query: 458 AIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGA 637
IFEI +F +N PF+ + KE F T +HYF+ ++ + LL ++QN+D LE A
Sbjct: 60 QIFEIKYFTKNQMPFYEMDKEFFSNKPHFTSAHYFMAEVNRREQLLFVFSQNVDGLELEA 119
Query: 638 GIPEEKLVEAHGTFYTSHC 694
G+P EKL + HG + + C
Sbjct: 120 GLPPEKLCQVHGNYRGARC 138
>UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 308
Score = 122 bits (295), Expect = 6e-27
Identities = 57/135 (42%), Positives = 86/135 (63%), Gaps = 1/135 (0%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQK-YELPQPQAIFEIN 475
++ + + + K+I L+GAGIS SAGIPDFRSPETGLY ++K Y++ PQ IF I
Sbjct: 55 IENFAEKLLAKKYKQIAFLTGAGISVSAGIPDFRSPETGLYAQIKKEYDISDPQKIFSIR 114
Query: 476 FFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
+++ NP PF + ++ F + PT +H I ++++ LL + TQNID LE GI K
Sbjct: 115 YYQDNPLPFMQVIRDFFSREYHPTYAHKLIHQIYKRKQLLINITQNIDGLELKTGINPSK 174
Query: 656 LVEAHGTFYTSHCLD 700
+V+AHG +HC++
Sbjct: 175 VVQAHGHMRKAHCVN 189
>UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 602
Score = 122 bits (295), Expect = 6e-27
Identities = 62/124 (50%), Positives = 79/124 (63%)
Frame = +2
Query: 323 KSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF 502
K KKII L+GAGISTS GIPDFRS E G Y L+ L PQ +F + FR+NP F
Sbjct: 262 KLKSAKKIIVLTGAGISTSLGIPDFRSSE-GFYSKLRNLGLDDPQDVFNLQIFRENPSVF 320
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
+ +A + P + H F++LL +K LLR+YTQNID LE AGI EK+V+ HG+F
Sbjct: 321 YNIAYMVLPPENIFSPLHSFLKLLQDKDKLLRNYTQNIDNLESYAGIKPEKMVQCHGSFA 380
Query: 683 TSHC 694
T+ C
Sbjct: 381 TASC 384
>UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;
n=3; Candida albicans|Rep: NAD-dependent histone
deacetylase SIR2 - Candida albicans (Yeast)
Length = 515
Score = 122 bits (294), Expect = 9e-27
Identities = 59/122 (48%), Positives = 84/122 (68%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R KKI+ ++GAGISTS GIPDFRS + GLY+ L K L PQ +F++ F + + F+T+
Sbjct: 233 RAKKIMVVTGAGISTSLGIPDFRSFK-GLYNQLSKLNLSDPQKVFDLQTFMREGRLFYTI 291
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
A + P K ++ H F++LL +K LLR+YTQNID LE+ AG+ EKLV+ HG+F +
Sbjct: 292 AHLVLPPDGKFSLLHAFLKLLQDKHKLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAK 351
Query: 692 CL 697
C+
Sbjct: 352 CV 353
>UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 522
Score = 122 bits (293), Expect = 1e-26
Identities = 60/134 (44%), Positives = 86/134 (64%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
SL+ ++ ++S KKI+ LSGAGISTS GIPDFRS + G Y L+ L PQ +F++
Sbjct: 198 SLEHVIDGLQS--AKKILVLSGAGISTSLGIPDFRSSQ-GFYAKLEHLGLSDPQDVFDLG 254
Query: 476 FFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
F +P F+ +A + P T H FI+ L +KG+LLR+YTQNID LE GI ++
Sbjct: 255 IFHTDPTVFYLIAHMILPPEHSFTPMHAFIKTLDDKGILLRNYTQNIDNLESNVGINSDR 314
Query: 656 LVEAHGTFYTSHCL 697
+V+ HG+F T+ C+
Sbjct: 315 VVQCHGSFATATCV 328
>UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 479
Score = 121 bits (291), Expect = 2e-26
Identities = 56/119 (47%), Positives = 82/119 (68%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
K I+ ++GAGISTS GIPDFRS TG Y L + +P+ +F+I+ F ++P+ F+ LA
Sbjct: 174 KNIMIITGAGISTSLGIPDFRSKNTGFYSRLLQMGYEEPEQVFDIHNFDEDPRTFYALAG 233
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
++ P K T +H FIRLL +K LL +YTQNID +E AGI ++KL++ HG++ T+ C
Sbjct: 234 DIIPDLEKWTPTHEFIRLLQDKEKLLTNYTQNIDNVEANAGILKDKLIQCHGSWATATC 292
>UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Pichia stipitis|Rep: NAD-dependent histone
deacetylase SIR2 - Pichia stipitis (Yeast)
Length = 391
Score = 121 bits (291), Expect = 2e-26
Identities = 58/120 (48%), Positives = 84/120 (70%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
KKI+ +SGAGISTS GIPDFRS + GLY L+ L PQ +F++ F+++P F+++A
Sbjct: 111 KKIMVISGAGISTSLGIPDFRSFK-GLYAQLEHLNLKDPQKVFDMGAFQKDPSIFYSIAH 169
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+ P + ++ H FI+LL +KG LLR+YTQNID LE GI +KL++ HG+F ++ CL
Sbjct: 170 LVLPPEGRFSMLHSFIKLLQDKGKLLRNYTQNIDNLESRVGIHPDKLIQCHGSFGSASCL 229
>UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_145,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 258
Score = 119 bits (287), Expect = 6e-26
Identities = 56/138 (40%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 293 VSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEI 472
++L+ ++R +K+ KKI +GAGIS +AG+ D+RS +TGLY L+K+ L P+ +++I
Sbjct: 3 LTLNELIRKLKAKEFKKITIAAGAGISVAAGLSDYRSKDTGLYDQLKKFNLSNPEQVYDI 62
Query: 473 NFFRQNPKPFFTLAKELFPGS--FKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIP 646
N FR+NP +++++KE + +PT +H FI L LL +TQNID LE AG+
Sbjct: 63 NVFRKNPSLYYSVSKEFGTHNLDLQPTFAHQFIYHLDRNDQLLNCFTQNIDGLELVAGVR 122
Query: 647 EEKLVEAHGTFYTSHCLD 700
E K+++ HG T+ C+D
Sbjct: 123 ESKVIQVHGHRRTASCID 140
>UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1 -
Saccharomyces kluyveri (Yeast) (Saccharomyces
silvestris)
Length = 414
Score = 118 bits (285), Expect = 1e-25
Identities = 57/125 (45%), Positives = 80/125 (64%)
Frame = +2
Query: 323 KSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF 502
K ++++ L+GAGISTS GIPDFRS E G Y ++ L PQ +F + F Q+P F
Sbjct: 79 KLKTARRVLVLTGAGISTSLGIPDFRSSE-GFYSKIKHLGLDDPQDVFNYDIFMQDPSVF 137
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
+ +A + P + H FIR++ +KG LLR+YTQNID LE AGI EK+V+ HG+F
Sbjct: 138 YNIAHMVLPPENLYSPLHSFIRMIQDKGKLLRNYTQNIDNLESYAGIQAEKMVQCHGSFA 197
Query: 683 TSHCL 697
T+ C+
Sbjct: 198 TASCV 202
>UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;
n=13; Saccharomycetales|Rep: NAD-dependent histone
deacetylase SIR2 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 562
Score = 117 bits (281), Expect = 3e-25
Identities = 58/125 (46%), Positives = 78/125 (62%)
Frame = +2
Query: 323 KSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF 502
K +KI+ L+GAG+STS GIPDFRS E G Y ++ L PQ +F N F +P F
Sbjct: 250 KLHTARKILVLTGAGVSTSLGIPDFRSSE-GFYSKIKHLGLDDPQDVFNYNIFMHDPSVF 308
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
+ +A + P + H FI++L KG LLR+YTQNID LE AGI +KLV+ HG+F
Sbjct: 309 YNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFA 368
Query: 683 TSHCL 697
T+ C+
Sbjct: 369 TATCV 373
>UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;
n=1; Schizosaccharomyces pombe|Rep: NAD-dependent
histone deacetylase sir2 - Schizosaccharomyces pombe
(Fission yeast)
Length = 475
Score = 117 bits (281), Expect = 3e-25
Identities = 56/134 (41%), Positives = 88/134 (65%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
+ + +V +K + K ++ L GAGISTS GI DFRS + G Y L ++ L +P +F+I+
Sbjct: 145 TFEDVVNLLK--KAKNVVVLVGAGISTSLGILDFRS-DNGFYARLARHGLSEPSEMFDIH 201
Query: 476 FFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
FR+NP+ F+T A++L P + + SH FIRLL +K L +TQNID LE+ G+ + K
Sbjct: 202 TFRENPEIFYTFARDLLPETNHYSPSHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNK 261
Query: 656 LVEAHGTFYTSHCL 697
+++ HG+F T+ C+
Sbjct: 262 IIQCHGSFATATCI 275
>UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetylase;
n=2; Candida albicans|Rep: Potential Sir2 family histone
deacetylase - Candida albicans (Yeast)
Length = 657
Score = 116 bits (279), Expect = 6e-25
Identities = 55/123 (44%), Positives = 81/123 (65%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT 508
+ K I+ ++GAGISTS GIPDFRS + G Y +Q L PQ +F+++ F +P F++
Sbjct: 299 ENSKNIMVITGAGISTSLGIPDFRSSQ-GFYSMIQHLGLSDPQEVFDLDLFLNDPNIFYS 357
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
+A + P + + H FI+LL +K LLR+YTQNID LE AGI +E L++ HG+F T+
Sbjct: 358 IAHMILPPNHIYSPLHSFIKLLQDKNKLLRNYTQNIDNLESYAGIHKENLIQCHGSFATA 417
Query: 689 HCL 697
C+
Sbjct: 418 SCI 420
>UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Lodderomyces elongisporus NRRL YB-4239|Rep:
NAD-dependent histone deacetylase SIR2 - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 568
Score = 115 bits (276), Expect = 1e-24
Identities = 59/121 (48%), Positives = 80/121 (66%), Gaps = 2/121 (1%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
KI+ ++GAGISTS GIPDFRS + G Y +Q L PQ +F++ F +P F+++A
Sbjct: 258 KILVITGAGISTSLGIPDFRSSQ-GFYSMVQHLGLSDPQEVFDLLIFNSDPSLFYSIAHM 316
Query: 521 LFP--GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+ P +F P H FI LL +KG LLR+YTQNID LE AGI EK+V+ HG+F T+ C
Sbjct: 317 VLPPENTFSPL--HSFIYLLQQKGKLLRNYTQNIDNLESYAGIVPEKMVQCHGSFATATC 374
Query: 695 L 697
+
Sbjct: 375 V 375
>UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 403
Score = 114 bits (275), Expect = 2e-24
Identities = 58/123 (47%), Positives = 79/123 (64%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT 508
++ KKI+ ++GAGISTS GIPDFRS + G+Y L + L Q +F I+ F ++P F+
Sbjct: 114 EKAKKILVVTGAGISTSLGIPDFRSFQ-GIYSQLSRSGLENAQQVFHIDRFCKDPTLFYL 172
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
+A ++ P K + H F+RLL +K LLR YTQNID LE AGI ++V HGT TS
Sbjct: 173 VAHKILPQGDKVSDFHRFLRLLEQKNKLLRVYTQNIDNLELAAGIDPSRIVHCHGTLSTS 232
Query: 689 HCL 697
CL
Sbjct: 233 TCL 235
>UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 320
Score = 114 bits (274), Expect = 2e-24
Identities = 59/125 (47%), Positives = 81/125 (64%), Gaps = 3/125 (2%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNL--QKYELPQPQAIFEINFFRQNPKPF 502
+ + I+ L GAGISTS GIPDFRS + GLY +L + L PQ +F++ F Q+P PF
Sbjct: 58 ETAQNIVVLCGAGISTSLGIPDFRSAD-GLYKSLDLESLGLSDPQEVFDLEVFDQDPTPF 116
Query: 503 FTLA-KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTF 679
+ +A K + P + +H F++LL +KG LLR YTQNID LE AGI E K+V+ HG F
Sbjct: 117 YRVASKVMMPTQALISPTHAFLKLLQDKGKLLRIYTQNIDDLEHIAGIEESKMVQCHGAF 176
Query: 680 YTSHC 694
+ + C
Sbjct: 177 HMATC 181
>UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 526
Score = 113 bits (272), Expect = 4e-24
Identities = 58/119 (48%), Positives = 75/119 (63%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
KKII ++GAGISTS GIPDFRS GLY L PQ IF I F+++P FF +AK
Sbjct: 204 KKIIVITGAGISTSLGIPDFRSAN-GLYAQFGHLNLNDPQEIFNIEKFKEDPSIFFGVAK 262
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+ P + + +H FI LL G LL +YTQNID +E AGI +K++ HG+F T+ C
Sbjct: 263 VILPEIRRFSPTHQFIALLQAHGKLLTNYTQNIDNIESMAGISPDKIIHCHGSFATATC 321
>UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 180
Score = 93.5 bits (222), Expect = 5e-18
Identities = 50/132 (37%), Positives = 73/132 (55%), Gaps = 5/132 (3%)
Frame = +2
Query: 320 IKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQ---PQAIFEINFFRQN 490
+KS K ++ ++G+GI + GIPD S L ++ P +F+I FFR+N
Sbjct: 12 LKSGNYKNVVVMTGSGICNACGIPDLHSIIPDLNKKAEETGFTPYMTPPFVFDIRFFREN 71
Query: 491 PKPFFTLAKELFPGSFKP--TISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVE 664
PKPF+ + E++P + P T H IRL+ E GLL R YT N D LE A + K+V+
Sbjct: 72 PKPFWWVFSEIWPWNEMPLPTDFHILIRLIEEMGLLRRWYTTNTDCLELDAIKDKSKVVQ 131
Query: 665 AHGTFYTSHCLD 700
HG+ HC+D
Sbjct: 132 CHGSVKHCHCID 143
>UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR2
family; n=2; Pelobacter|Rep: NAD-dependent protein
deacetylases, SIR2 family - Pelobacter carbinolicus
(strain DSM 2380 / Gra Bd 1)
Length = 278
Score = 91.1 bits (216), Expect = 2e-17
Identities = 50/128 (39%), Positives = 81/128 (63%), Gaps = 2/128 (1%)
Frame = +2
Query: 320 IKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKP 499
I+ RC ++TLSGAGIST+AGIPDFR P+ GLY ++Y+ P+ +F+I++F + P+
Sbjct: 29 IRRSRC--VVTLSGAGISTAAGIPDFRGPQ-GLYVT-RRYD---PEKVFDIDWFHREPRY 81
Query: 500 FFTLAKELFP--GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHG 673
F+ ++ + +PT +H F+ L + G L TQNID L + AG K+++ HG
Sbjct: 82 FYEFTRDFVSTVKAIRPTFTHRFLAGLEKAGGLAGLITQNIDMLHQLAG--SRKVIDLHG 139
Query: 674 TFYTSHCL 697
++ ++ CL
Sbjct: 140 SYRSAQCL 147
>UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 347
Score = 90.6 bits (215), Expect = 3e-17
Identities = 56/137 (40%), Positives = 82/137 (59%), Gaps = 3/137 (2%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYE-LPQPQAIFEI 472
S++ I++ I++ K II + GAG S PDFRSP GLY ++ K L P +F++
Sbjct: 57 SMEDIIKLIENS--KHIIVIIGAGASIG---PDFRSPG-GLYDSIAKEGCLEDPYQVFDL 110
Query: 473 NFFRQNPKPFFTLAKELFPGSFKPTIS--HYFIRLLHEKGLLLRHYTQNIDTLERGAGIP 646
++F+++P F+ A ++FP P S HYFI L G L R Y+QN+DTLE G+P
Sbjct: 111 DYFKKDPTIFWRFAHKIFPDK-NPAHSDTHYFIAELENHGKLQRLYSQNVDTLE--CGVP 167
Query: 647 EEKLVEAHGTFYTSHCL 697
E KL HG++ S+CL
Sbjct: 168 ESKLRCVHGSWRNSYCL 184
>UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4;
Thermotoga|Rep: NAD-dependent deacetylase - Thermotoga
maritima
Length = 246
Score = 89.8 bits (213), Expect = 6e-17
Identities = 52/119 (43%), Positives = 74/119 (62%), Gaps = 2/119 (1%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE-L 523
+TL+GAGIST +GIPDFR P G+Y +KY Q +F+I+FF +P+ F+ AKE +
Sbjct: 17 VTLTGAGISTPSGIPDFRGP-NGIY---KKYS----QNVFDIDFFYSHPEEFYRFAKEGI 68
Query: 524 FPG-SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
FP KP ++H + L EKGL+ TQNID L + AG +K++E HG +C+
Sbjct: 69 FPMLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAG--SKKVIELHGNVEEYYCV 125
>UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2;
Filobasidiella neoformans|Rep: Hst3 protein, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 389
Score = 85.0 bits (201), Expect = 2e-15
Identities = 53/112 (47%), Positives = 70/112 (62%), Gaps = 8/112 (7%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQP----QAIFEINFFR--QNP 493
+ ++I+T+SGAGIS S+GIPDFRS E GLY +L K + P + +F F Q+
Sbjct: 34 KARRIVTVSGAGISCSSGIPDFRS-EGGLY-SLVKEKYPDAFFTGKDLFSAGTFANPQST 91
Query: 494 KPFFTLAKELFP--GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
F+T ELF S +PT +H+FIR L +KG LLR YTQNID ER G+
Sbjct: 92 SIFYTFIAELFHCCASAQPTRTHHFIRKLEQKGKLLRSYTQNIDGFERRMGL 143
>UniRef50_A6DC77 Cluster: Silent information regulator protein Sir2;
n=1; Caminibacter mediatlanticus TB-2|Rep: Silent
information regulator protein Sir2 - Caminibacter
mediatlanticus TB-2
Length = 243
Score = 83.4 bits (197), Expect = 5e-15
Identities = 52/124 (41%), Positives = 72/124 (58%), Gaps = 3/124 (2%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
K ++ +GAGIS +GIP FR P TGL+ KY+ P+ I +I+FF QNPK + K
Sbjct: 15 KNLVAFTGAGISVESGIPTFRGP-TGLW---SKYD---PK-ILDIDFFIQNPKESWKYIK 66
Query: 518 ELFPG---SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
E+F KP +HYF+ L +KG+L TQNID L + AG + ++E HGT
Sbjct: 67 EIFYDYMQDIKPNEAHYFLADLEKKGILKAVITQNIDNLHQKAG--SKNVIEFHGTANKL 124
Query: 689 HCLD 700
CL+
Sbjct: 125 ECLN 128
>UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family
protein; n=4; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 375
Score = 83.4 bits (197), Expect = 5e-15
Identities = 51/134 (38%), Positives = 77/134 (57%), Gaps = 2/134 (1%)
Frame = +2
Query: 302 DGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKY-ELPQPQAIFEINF 478
D I+R I D+ KI+ + GAG S PDFRSP GLY ++ K P +F+++
Sbjct: 81 DSIIRLI--DQASKIVVILGAGGSVG---PDFRSPG-GLYDSIAKEGAFEDPCQVFDLDT 134
Query: 479 FRQNPKPFFTLAKELFPGSF-KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
F +P F+ A +FP + + + +HYF+ L ++G LLR YTQN+D L+ GI E
Sbjct: 135 FMDDPSVFWRFAHTIFPERYPRHSQAHYFLENLEKRGKLLRLYTQNVDALD--VGILPEH 192
Query: 656 LVEAHGTFYTSHCL 697
L HG++ S+C+
Sbjct: 193 LRCVHGSWRESYCM 206
>UniRef50_Q54LF0 Cluster: Ankyrin repeat-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Ankyrin
repeat-containing protein - Dictyostelium discoideum AX4
Length = 778
Score = 83.0 bits (196), Expect = 6e-15
Identities = 51/141 (36%), Positives = 72/141 (51%), Gaps = 9/141 (6%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ---KYELPQPQAIFE 469
L ++ IK K +I LSGAGIS +AGIP +R+ + L N Q E+ +
Sbjct: 476 LKNVINGIKKGEFKNVIVLSGAGISANAGIPPYRTKDGLLAKNKQFSFSMEILEKHPDVF 535
Query: 470 INFFRQNPKPFFTLAKEL-----FPGSFKPTISHYFIRLLHEK-GLLLRHYTQNIDTLER 631
R + P + + K T SHYFI L+EK G LLR+YTQN+D L+
Sbjct: 536 YQAIRDHFYPIIKASNDNDRDDGISAGIKSTKSHYFINDLNEKYGCLLRNYTQNVDPLQE 595
Query: 632 GAGIPEEKLVEAHGTFYTSHC 694
G P +K++ AHG+F +C
Sbjct: 596 RTGTPTDKIIHAHGSFDQWYC 616
>UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2;
Bacteria|Rep: Putative uncharacterized protein -
Bacteroides capillosus ATCC 29799
Length = 262
Score = 81.4 bits (192), Expect = 2e-14
Identities = 50/129 (38%), Positives = 73/129 (56%), Gaps = 2/129 (1%)
Frame = +2
Query: 314 RWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNP 493
RWI D +I+ GAG+ST +GIPDFRS + GLY+ Q+Y+ P P+ I F+ P
Sbjct: 30 RWI--DESSRIVFFGGAGVSTESGIPDFRSVD-GLYN--QQYDYP-PETILSHTFYEARP 83
Query: 494 KPFFTL--AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEA 667
+ FF K LFP + +P +H + L + G L TQNID L + AG + ++E
Sbjct: 84 EEFFRFYRNKMLFPDA-QPNAAHKKLAELEQAGKLTAMVTQNIDGLHQKAG--SKNVLEL 140
Query: 668 HGTFYTSHC 694
HG+ ++C
Sbjct: 141 HGSVLRNYC 149
>UniRef50_A4M603 Cluster: Silent information regulator protein Sir2;
n=1; Petrotoga mobilis SJ95|Rep: Silent information
regulator protein Sir2 - Petrotoga mobilis SJ95
Length = 256
Score = 81.4 bits (192), Expect = 2e-14
Identities = 46/119 (38%), Positives = 71/119 (59%), Gaps = 2/119 (1%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKEL 523
I LSGAG+ST+AGIPDFR P G+Y K + P+ IF++++F +P F+ K+
Sbjct: 18 IAVLSGAGMSTNAGIPDFRGP-NGIY---TKANIENPERIFDLDYFYLDPSLFYKFHKKF 73
Query: 524 --FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+ +PT +H F+ L ++G L TQNID+L + AG +K+ E HG + ++C
Sbjct: 74 LEYITKAEPTFTHKFLVQLEKEGKLKGIVTQNIDSLHQKAG--SKKVYEIHGGCWKNYC 130
>UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7;
Bacteria|Rep: NAD-dependent deacetylase - Clostridium
acetobutylicum
Length = 245
Score = 79.8 bits (188), Expect = 6e-14
Identities = 44/121 (36%), Positives = 68/121 (56%), Gaps = 2/121 (1%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE- 520
I+ GAG+ST + IPDFRS E GLY + P P+ + FF+ + + FF +E
Sbjct: 20 IVFFGGAGVSTESNIPDFRS-ENGLYKTKNNFSYP-PEVMLSHTFFKNHTEDFFEFYREK 77
Query: 521 -LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+F + KP +HY + + E+G L TQNID L + AG + + E HG+ + ++C+
Sbjct: 78 MIFKDA-KPNAAHYSLAKIEEQGKLKAIVTQNIDGLHQLAG--SKNVYELHGSIHRNYCM 134
Query: 698 D 700
D
Sbjct: 135 D 135
>UniRef50_Q6BPA4 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=6;
Saccharomycetales|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 438
Score = 79.0 bits (186), Expect = 1e-13
Identities = 50/107 (46%), Positives = 67/107 (62%), Gaps = 8/107 (7%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQP----QAIFEINFFRQNP-- 493
+ +K + L+GAGIS +AGIPDFRS + GLY N+ K + P+ Q +F+I+ FR
Sbjct: 27 KSRKAVVLTGAGISCNAGIPDFRSSD-GLY-NMVKSKFPKKIVKGQDLFDISIFRDEVTL 84
Query: 494 KPFFTLAKELFPGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
F T + L+ S KPT +H FI++L EK LLR YTQNID LE
Sbjct: 85 SLFCTFMESLYLSSIDAKPTETHRFIKILKEKKKLLRCYTQNIDGLE 131
>UniRef50_A6LP94 Cluster: Silent information regulator protein Sir2;
n=1; Thermosipho melanesiensis BI429|Rep: Silent
information regulator protein Sir2 - Thermosipho
melanesiensis BI429
Length = 234
Score = 78.6 bits (185), Expect = 1e-13
Identities = 52/122 (42%), Positives = 65/122 (53%), Gaps = 5/122 (4%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKEL 523
++ L+GAGISTS+GIPDFRS E GLY YEL F FF+ +P F+ K+
Sbjct: 14 VVALTGAGISTSSGIPDFRS-EDGLYKE-YGYEL------FSYEFFKNHPDIFYEYIKKE 65
Query: 524 FPGSFKP--TISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGT---FYTS 688
FP +K +SH + L E G LL TQNID L AG ++E HG FY
Sbjct: 66 FPKMYKANYNMSHKLLAELEEMGYLLGVITQNIDDLHNKAG--SRNVIELHGNATHFYCE 123
Query: 689 HC 694
C
Sbjct: 124 EC 125
>UniRef50_UPI000049979A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 319
Score = 77.4 bits (182), Expect = 3e-13
Identities = 55/138 (39%), Positives = 78/138 (56%), Gaps = 2/138 (1%)
Frame = +2
Query: 290 EVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFE 469
E S + R I R K+++ L+GAGIS SAGIPDFRS G++ ++YE P+ A +E
Sbjct: 14 EFSCKSLARIIS--RSKRLVVLTGAGISVSAGIPDFRS-RNGMW---KRYE-PKVYASYE 66
Query: 470 INFFRQNPKPFFTLAKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
NF + P+ F+ + EL KPT +H+ +R L E G L TQN+D L + AG
Sbjct: 67 -NFVNK-PEMFWKMCNELRNCTEGKKPTKAHFALRKLEEIGKLEEIITQNVDNLHQLAG- 123
Query: 644 PEEKLVEAHGTFYTSHCL 697
K++E HGT C+
Sbjct: 124 -SRKVIELHGTGKICQCI 140
>UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1;
Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
Regulatory protein, sir2 family - Syntrophomonas wolfei
subsp. wolfei (strain Goettingen)
Length = 253
Score = 77.4 bits (182), Expect = 3e-13
Identities = 47/130 (36%), Positives = 73/130 (56%), Gaps = 2/130 (1%)
Frame = +2
Query: 290 EVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFE 469
E ++D +V + DR + ++GAGIST AGIPDFR PE G+Y L + + I
Sbjct: 2 EKNIDRVVEIL--DRSHNTVVVTGAGISTEAGIPDFRGPE-GIYRKLGENRV---MKIIN 55
Query: 470 INFFRQNPKPFFTLAKE--LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
I+FFR NP F+ ++ +FP +P +H + + + G++ TQNID L + AG
Sbjct: 56 IDFFRNNPLEFYKFYRQYFIFP-PVEPGKAHQVLAEMEKAGIIKAIVTQNIDNLHQKAG- 113
Query: 644 PEEKLVEAHG 673
+K++ HG
Sbjct: 114 -SQKVIPIHG 122
>UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1;
Thermoanaerobacter tengcongensis|Rep: NAD-dependent
deacetylase 2 - Thermoanaerobacter tengcongensis
Length = 250
Score = 77.4 bits (182), Expect = 3e-13
Identities = 42/122 (34%), Positives = 69/122 (56%), Gaps = 2/122 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
+K + L+GAGIST +GIPDFRSP TGL+ N+ E+ + +F +P+ F+ +
Sbjct: 21 QKTMVLTGAGISTESGIPDFRSPGTGLWENMDPTEVLSTKVLF------NSPEEFYRVGF 74
Query: 518 ELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
++ + +P +HY + + ++G++ TQNID L + AG +K+ E HG
Sbjct: 75 KILSSMRNAEPNEAHYILSEMEKEGIIAGVITQNIDNLHQKAG--SKKVYEVHGNTREGS 132
Query: 692 CL 697
CL
Sbjct: 133 CL 134
>UniRef50_A7HL19 Cluster: Silent information regulator protein Sir2;
n=1; Fervidobacterium nodosum Rt17-B1|Rep: Silent
information regulator protein Sir2 - Fervidobacterium
nodosum Rt17-B1
Length = 244
Score = 75.8 bits (178), Expect = 1e-12
Identities = 50/132 (37%), Positives = 72/132 (54%), Gaps = 2/132 (1%)
Frame = +2
Query: 308 IVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQ 487
+V W+K+ + ++T GAG+S +GIPDFRS + G+Y K+ Q IF+I+ F Q
Sbjct: 7 LVSWLKNSKFTTVLT--GAGVSVPSGIPDFRS-KNGVY---SKW----GQEIFDIDLFHQ 56
Query: 488 NPKPFFTLAK-ELFPG-SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLV 661
NP F+ AK EL +P HY + L + ++ TQNID L + AG +K+
Sbjct: 57 NPDRFYEFAKQELIKMLDVEPNEIHYLLAYLEKLNIVKGVITQNIDNLHKKAG--SQKVA 114
Query: 662 EAHGTFYTSHCL 697
E HG T CL
Sbjct: 115 EIHGNVRTWSCL 126
>UniRef50_A4J646 Cluster: Silent information regulator protein Sir2;
n=2; Peptococcaceae|Rep: Silent information regulator
protein Sir2 - Desulfotomaculum reducens MI-1
Length = 256
Score = 75.8 bits (178), Expect = 1e-12
Identities = 47/121 (38%), Positives = 68/121 (56%), Gaps = 2/121 (1%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
K I L+GAGIST +GIPDFRS TGL++ +Y+ PQ + I ++NP+ F+ L +
Sbjct: 19 KTIALTGAGISTESGIPDFRSKNTGLWN---QYD---PQEVASIQALKKNPESFYALNFQ 72
Query: 521 LFPGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+ KP +H+ + L + G LL TQNID L + AG +++ E HG C
Sbjct: 73 WWDVCLKAKPNNAHFALARLEKMGWLLGVITQNIDGLHQHAG--SKRVWEVHGNLKGCSC 130
Query: 695 L 697
L
Sbjct: 131 L 131
>UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3;
Bacteria|Rep: NAD-dependent deacetylase 2 - Geobacillus
kaustophilus
Length = 247
Score = 74.9 bits (176), Expect = 2e-12
Identities = 49/133 (36%), Positives = 67/133 (50%), Gaps = 4/133 (3%)
Frame = +2
Query: 308 IVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQ 487
+ +WIK I L+GAG+ST +GIPDFRS E GLY E + ++++
Sbjct: 7 LAQWIKE--ANTIAVLTGAGMSTESGIPDFRS-ENGLYAQEDNVEYYLSEY-----YYKK 58
Query: 488 NPKPFFTLAKELFP----GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK 655
+P F+ K +F G F P H F+R L E G + TQNID L AG
Sbjct: 59 DPVDFWRRFKRMFSLKMMGGFAPNDGHRFLRWLEEMGKTVTILTQNIDGLHTKAG--STN 116
Query: 656 LVEAHGTFYTSHC 694
++E HGT T+ C
Sbjct: 117 VIELHGTLQTATC 129
>UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Clostridium
tetani
Length = 247
Score = 74.5 bits (175), Expect = 2e-12
Identities = 42/120 (35%), Positives = 66/120 (55%), Gaps = 1/120 (0%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKEL 523
I+ GAG+ST + IPDFRS E GLY + P+ + +FF+++ + FF KE
Sbjct: 17 IVFFGGAGVSTESNIPDFRS-EEGLYKTKSNFSY-SPEVMLSHSFFKEHTEDFFDFYKEK 74
Query: 524 FPGSF-KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
+ KP ++H+ + L + G L TQNID L + AG + ++E HG ++C+D
Sbjct: 75 MIYKYAKPNLAHHALAKLEKVGKLKAIITQNIDGLHQLAG--SKNVIELHGGVGRNYCMD 132
>UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacillus
cereus group|Rep: NAD-dependent deacetylase - Bacillus
anthracis
Length = 242
Score = 74.1 bits (174), Expect = 3e-12
Identities = 45/126 (35%), Positives = 67/126 (53%), Gaps = 4/126 (3%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT 508
++ KKI L+GAG ST +GIPDFRS GLY + + ++ ++PK F+
Sbjct: 12 EKAKKITVLTGAGASTESGIPDFRS-ANGLYAD------ANVEMYLSRGYYNRSPKEFWK 64
Query: 509 LAKELFP----GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGT 676
KE+F +KP H F+ L E+G + TQNID L + G + +++ HGT
Sbjct: 65 HYKEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGG--SKHVIDLHGT 122
Query: 677 FYTSHC 694
T+HC
Sbjct: 123 LQTAHC 128
>UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Treponema
denticola|Rep: NAD-dependent deacetylase - Treponema
denticola
Length = 251
Score = 72.5 bits (170), Expect = 9e-12
Identities = 42/125 (33%), Positives = 71/125 (56%), Gaps = 2/125 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
+ + ++ +GAGIST AGI DFR + GL Y+ P + +F+I+ F ++P ++ +
Sbjct: 17 KARHLVAFTGAGISTLAGIKDFRGKD-GL------YKQPNTEKMFDIDVFYRDPSVYYGM 69
Query: 512 AKELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
AKE G +P I H + L ++G+L TQNID L + AG + ++E HG+
Sbjct: 70 AKEFIYGLEEKQPAIVHTVLADLEKRGILKAVITQNIDLLHQKAG--SKNVIEVHGSPSV 127
Query: 686 SHCLD 700
+C++
Sbjct: 128 HYCIN 132
>UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;
n=6; Saccharomycetales|Rep: NAD-dependent histone
deacetylase HST3 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 447
Score = 71.7 bits (168), Expect = 2e-11
Identities = 53/145 (36%), Positives = 79/145 (54%), Gaps = 14/145 (9%)
Frame = +2
Query: 251 DLEPAEPPEKVLDEVSLDG---IVRWIKSD--RCKKIITLSGAGISTSAGIPDFRSPETG 415
DL + EK+ + LD ++R + R ++I L+GAGIS +AGIPDFRS + G
Sbjct: 19 DLPSSLQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSD-G 77
Query: 416 LYHNLQK-----YELPQPQAIFEINFFRQNPKP--FFTLAKELFPGS--FKPTISHYFIR 568
LY ++K + + + +F+I+ FR + K F + L+ KPT +H FI
Sbjct: 78 LYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIA 137
Query: 569 LLHEKGLLLRHYTQNIDTLERGAGI 643
L ++ LLR YTQNID LE G+
Sbjct: 138 HLKDRNKLLRCYTQNIDGLEESIGL 162
>UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces
cerevisiae HST3 protein; n=1; Yarrowia lipolytica|Rep:
Similar to sp|P53687 Saccharomyces cerevisiae HST3
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 385
Score = 71.3 bits (167), Expect = 2e-11
Identities = 45/137 (32%), Positives = 71/137 (51%), Gaps = 15/137 (10%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELP----------QPQAIFEINFF 481
+CK+++ ++GAGIS SAGIPDFRS + + +K E + + +F+ +
Sbjct: 23 KCKRVVCVTGAGISCSAGIPDFRSQQIAIGKGKKKDESQGLYFQQFGNLKGRELFDASIL 82
Query: 482 RQNPKP-----FFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIP 646
++ F T K+ S +PT H F+ L G LL YTQNID+LE +
Sbjct: 83 KREDTTLTFMSFMTALKQQCQAS-RPTRVHEFVAKLDTAGKLLSCYTQNIDSLEHKTEVS 141
Query: 647 EEKLVEAHGTFYTSHCL 697
+K+V+ HG T +C+
Sbjct: 142 AKKIVQLHGHLDTLNCI 158
>UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3;
Pyrobaculum|Rep: NAD-dependent deacetylase 1 -
Pyrobaculum aerophilum
Length = 254
Score = 70.5 bits (165), Expect = 4e-11
Identities = 46/134 (34%), Positives = 70/134 (52%), Gaps = 2/134 (1%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
LD + I C + L+GAG+ST++GIPDFR P+ G++ + P+ FEI++
Sbjct: 10 LDEVASLIARSSCN--VALTGAGVSTASGIPDFRGPQ-GVWRRVD----PEK---FEISY 59
Query: 479 FRQNPKPFFTL-AKELFPG-SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEE 652
F NP + L K L P + KP +HY + + G L TQN+D L + AG +
Sbjct: 60 FYNNPDEVWDLFVKYLLPAFNVKPNPAHYALAEMERLGKLCAVITQNVDRLHQAAG--SK 117
Query: 653 KLVEAHGTFYTSHC 694
++E HG + C
Sbjct: 118 NVIELHGALEYAVC 131
>UniRef50_Q2HG51 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Chaetomium globosum (Soil fungus)
Length = 594
Score = 70.1 bits (164), Expect = 5e-11
Identities = 41/103 (39%), Positives = 66/103 (64%), Gaps = 6/103 (5%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KYEL-PQPQAIFEINFFR--QNPKPFF 505
KKI+ ++GAGIS SAGIPDFRS TGL+ L+ +++L + +F+ + ++ + + F
Sbjct: 50 KKIVVIAGAGISVSAGIPDFRS-STGLFATLRGQHKLKASGKHLFDASVYKHDSSTESFH 108
Query: 506 TLAKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
T+ +EL KPT H+ + + +G L+R Y+QNIDTL+
Sbjct: 109 TMVRELAQMTSDAKPTPFHHMLASIAAEGRLMRMYSQNIDTLD 151
>UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14;
Bacilli|Rep: NAD-dependent deacetylase - Enterococcus
faecalis (Streptococcus faecalis)
Length = 237
Score = 68.9 bits (161), Expect = 1e-10
Identities = 42/139 (30%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
Frame = +2
Query: 284 LDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAI 463
+ +++ + W+ + + KI L+GAGIST++G+PD+RS + G+Y +Q QP+ +
Sbjct: 1 MQDITQAEAIHWLATQQ--KITFLTGAGISTASGVPDYRSLK-GVYQGIQ-----QPEYL 52
Query: 464 FEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHE--KGLLLRHYTQNIDTLERGA 637
+ P+ F+ K L+ +P I H + L + +G ++ +QNID L R A
Sbjct: 53 LSRTCLKTEPEKFYQFVKTLYHPDAQPNIIHQKMAQLEQMKRGKIV---SQNIDGLHRKA 109
Query: 638 GIPEEKLVEAHGTFYTSHC 694
G +++V+ HG Y +C
Sbjct: 110 G--SQEVVDFHGNLYECYC 126
>UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 442
Score = 68.5 bits (160), Expect = 1e-10
Identities = 49/157 (31%), Positives = 81/157 (51%), Gaps = 4/157 (2%)
Frame = +2
Query: 236 LFSPQ---DLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRS- 403
LF+P+ E + PE++ + ++ ++ ++ + K + L+GAG+ST++GIPD+RS
Sbjct: 36 LFNPRLKDTQEHQDSPEQI--DTKVNQLIELLQ--KSKNAVILTGAGVSTASGIPDYRSG 91
Query: 404 PETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEK 583
T L K+EL + + F + KP LA FP PT H I L+++
Sbjct: 92 ANTILKTGPGKWELEENKK----KFLEEKGKPQIILAINAFPS---PT--HMAISKLYKE 142
Query: 584 GLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
L+ TQN+D L +GIP + + E HG + C
Sbjct: 143 NLIKSVITQNVDNLHHQSGIPRKDIHELHGNIISERC 179
>UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8;
Thermoprotei|Rep: NAD-dependent deacetylase - Sulfolobus
tokodaii
Length = 250
Score = 67.7 bits (158), Expect = 3e-10
Identities = 44/120 (36%), Positives = 67/120 (55%), Gaps = 2/120 (1%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELF 526
I +GAGIST++GIPDFR P GL+ +KY P+ + I +F+++PK F+ +
Sbjct: 17 IAFTGAGISTASGIPDFRGP-NGLW---KKYS-PE---LATIEYFKKDPKGFWEFYRLRM 68
Query: 527 PGSFK--PTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
G F P +HY + L + GL+ TQNID L + AG ++E HG +C++
Sbjct: 69 RGLFTALPNRAHYALAELEKMGLIRAIITQNIDGLHQLAG--SRNVIELHGNMRKCYCVN 126
>UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3;
Bacillus|Rep: NAD-dependent deacetylase - Bacillus
subtilis
Length = 247
Score = 67.7 bits (158), Expect = 3e-10
Identities = 43/123 (34%), Positives = 70/123 (56%), Gaps = 4/123 (3%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
++I+ L+GAG+ST +GIPDFRS G++ + + +A+ +++F P+ F+ K
Sbjct: 12 QRIVVLTGAGMSTESGIPDFRS-AGGIWTE----DASRMEAM-SLDYFLSYPRLFWPKFK 65
Query: 518 ELF----PGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
ELF GSF+P H + L ++G + +TQNID L + AG + E HG+ T
Sbjct: 66 ELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAG--SRHVYELHGSIQT 123
Query: 686 SHC 694
+ C
Sbjct: 124 AAC 126
>UniRef50_UPI000049971A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 285
Score = 66.5 bits (155), Expect = 6e-10
Identities = 44/149 (29%), Positives = 78/149 (52%)
Frame = +2
Query: 254 LEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ 433
LE E + D + +D + ++ K + L+GAGIS +GIPDFRS GL+ +
Sbjct: 8 LEELELYNSLDDSIDIDIEMIARSMEKSKNVTVLTGAGISVESGIPDFRS-SNGLW---K 63
Query: 434 KYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQN 613
+Y+ P + F+++P+ F+ + +E+ + P H + L + G++ TQN
Sbjct: 64 RYD---PSVYGSYSNFKKHPELFWKMTEEIHKITAYPNHVHEALAELEKIGVVKTIVTQN 120
Query: 614 IDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
+D L + AG + +VE HG+ +C+D
Sbjct: 121 VDGLHQQAG--SKNVVEMHGSGRACYCID 147
>UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1;
Symbiobacterium thermophilum|Rep: NAD-dependent
deacetylase - Symbiobacterium thermophilum
Length = 251
Score = 66.5 bits (155), Expect = 6e-10
Identities = 40/119 (33%), Positives = 63/119 (52%), Gaps = 2/119 (1%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELF 526
+ L+GAG ST +G+PDFRS TGL+ ++ P ++ + R+ P F+ + F
Sbjct: 19 VALTGAGASTESGLPDFRS-NTGLWKDVD------PVSLISMTALRRRPVDFYRFYRMRF 71
Query: 527 PGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+ +P H + L +GLL R TQN+D L + AG P+ ++E HG+ CL
Sbjct: 72 SHLWGAQPNPVHKVLAALQREGLLKRLITQNVDGLHQAAGSPD--VIELHGSLRECQCL 128
>UniRef50_Q9UR39 Cluster: NAD-dependent deacetylase hst4; n=1;
Schizosaccharomyces pombe|Rep: NAD-dependent deacetylase
hst4 - Schizosaccharomyces pombe (Fission yeast)
Length = 415
Score = 66.1 bits (154), Expect = 8e-10
Identities = 45/120 (37%), Positives = 73/120 (60%), Gaps = 6/120 (5%)
Frame = +2
Query: 287 DEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KYELP-QPQA 460
+ V L +V I+ + K+I+ ++GAGIS AGIPDFRS E GL+ +L+ +Y+L +
Sbjct: 43 ENVDLSPLVSAIR--KAKRIVVVTGAGISCDAGIPDFRSSE-GLFSSLRAEYKLNCSGKE 99
Query: 461 IFEINFFR--QNPKPFFTLAKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
+F+ + +R ++ F + ++L + +PT H F+ L ++ LLR YTQNID LE
Sbjct: 100 LFDGSVYRDLKSVNIFHAMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLE 159
>UniRef50_Q0UMU7 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 670
Score = 65.7 bits (153), Expect = 1e-09
Identities = 38/103 (36%), Positives = 66/103 (64%), Gaps = 6/103 (5%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQK-YELPQP-QAIFEINFFR--QNPKPFF 505
+KI+ ++GAGIS SAGIPDFRS TGL+++L+K ++L + +F+ + ++ + F
Sbjct: 125 RKIVVIAGAGISVSAGIPDFRS-ATGLFNSLKKEHKLKSSGKDLFDASVYQDDNSTSTFH 183
Query: 506 TLAKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
+ + L S +PT H+ + L ++G L+R YTQN+D ++
Sbjct: 184 DMVRTLSQHTKSAQPTAFHHLLATLAQEGRLMRLYTQNVDGID 226
>UniRef50_Q12Y78 Cluster: Silent information regulator protein Sir2;
n=1; Methanococcoides burtonii DSM 6242|Rep: Silent
information regulator protein Sir2 - Methanococcoides
burtonii (strain DSM 6242)
Length = 245
Score = 65.7 bits (153), Expect = 1e-09
Identities = 42/119 (35%), Positives = 66/119 (55%), Gaps = 2/119 (1%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELF 526
+ L+GAG+ST +GIPDFR +G+Y+ K++ IF I+ F ++P F+ +K
Sbjct: 15 VVLTGAGVSTFSGIPDFRG-RSGVYN---KFDA---DLIFSIDHFNKDPAYFYAHSKSFI 67
Query: 527 PG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+P+I H + L EKG++ TQNID L + AG + ++E HG+ CL
Sbjct: 68 YDLEHRQPSIVHSVLSKLEEKGIIKAIITQNIDMLHQKAG--SKNVIEVHGSPQEHVCL 124
>UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17;
Staphylococcus|Rep: NAD-dependent deacetylase -
Staphylococcus epidermidis (strain ATCC 12228)
Length = 246
Score = 65.3 bits (152), Expect = 1e-09
Identities = 42/121 (34%), Positives = 60/121 (49%), Gaps = 1/121 (0%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
+I+ +GAG+S ++GIPDFRS GLY + K + P+ + I+ N + F E
Sbjct: 18 QIVFFTGAGVSVASGIPDFRS-MGGLYDEISK-DGQSPEYLLSIDHLHDNKESFINFYHE 75
Query: 521 -LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
L KP I H +I L + L TQNID L AG + E HGT +C+
Sbjct: 76 RLLIADKKPNIVHQWIAQLENQQKSLGVITQNIDGLHEDAG--SHNIDELHGTLNRFYCI 133
Query: 698 D 700
+
Sbjct: 134 N 134
>UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1;
uncultured delta proteobacterium|Rep: Putative
uncharacterized protein - uncultured delta
proteobacterium
Length = 254
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/123 (33%), Positives = 63/123 (51%), Gaps = 2/123 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
+ K +I ++GAGIS +GIPDFRSP GL+ +E I+ F+++P + +
Sbjct: 14 KSKYVIAMTGAGISVESGIPDFRSP-GGLWSRFDPFEYA------HIDAFKRDPAKVWKM 66
Query: 512 AKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
E+ KP +HY + L G+L TQNID + + AG + ++E HG T
Sbjct: 67 LLEIDEVLNQAKPNRAHYALAKLEAAGILKAIITQNIDNMHQRAG--SKNVIEFHGNAET 124
Query: 686 SHC 694
C
Sbjct: 125 LTC 127
>UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putative;
n=8; Eurotiomycetidae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 320
Score = 64.9 bits (151), Expect = 2e-09
Identities = 44/138 (31%), Positives = 69/138 (50%)
Frame = +2
Query: 281 VLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQA 460
V+ L ++K CK+II L GAG+S S+G+P FR GL+ + + +L P+A
Sbjct: 5 VIPAADLRSFTEYLKG--CKRIIALCGAGLSASSGLPTFRGAG-GLWRSYEAMDLATPEA 61
Query: 461 IFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAG 640
FE N F++ + + + KP +HY + L + TQN+D L + A
Sbjct: 62 -FEAN--PDLVWHFYSYRRHMALKA-KPNRAHYALAELARRNRDFITLTQNVDDLSQRAN 117
Query: 641 IPEEKLVEAHGTFYTSHC 694
P E+L HG+ +T C
Sbjct: 118 HPSEQLHLLHGSLFTVKC 135
>UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7;
Bacillaceae|Rep: NAD-dependent deacetylase 1 -
Geobacillus kaustophilus
Length = 242
Score = 64.5 bits (150), Expect = 2e-09
Identities = 39/129 (30%), Positives = 63/129 (48%)
Frame = +2
Query: 308 IVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQ 487
I W+ + R + L+GAG+ST +G+PDFRSP TGL+ EL A++ R+
Sbjct: 3 ITSWLAASR--HTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATIDALYH---RRE 57
Query: 488 NPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEA 667
+ F+ +P H + +G++ TQN+D + AG +++E
Sbjct: 58 SFVEFYQYRIRTLQ-QCQPHDGHRLLADWERRGIVQTIVTQNVDGFHQEAG--SRRVIEL 114
Query: 668 HGTFYTSHC 694
HG+ T HC
Sbjct: 115 HGSLRTVHC 123
>UniRef50_A5UYK2 Cluster: Silent information regulator protein Sir2;
n=2; Roseiflexus|Rep: Silent information regulator
protein Sir2 - Roseiflexus sp. RS-1
Length = 261
Score = 63.7 bits (148), Expect = 4e-09
Identities = 39/125 (31%), Positives = 60/125 (48%), Gaps = 2/125 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R + ++GAGIST +GIPDFR P+ H P + ++ F +NP+ F+
Sbjct: 20 RAHSAVAITGAGISTPSGIPDFRGPDGAWKH-------VDPSEVASLHNFLRNPRAFYDW 72
Query: 512 AKELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
+ L + P +HY + L + L TQN D L + AG ++ E HG T
Sbjct: 73 FRPLLDRVLAAAPNAAHYALAALEQHRTLRAIITQNFDGLHQRAG--SREVYELHGHLRT 130
Query: 686 SHCLD 700
+ CL+
Sbjct: 131 ATCLE 135
>UniRef50_Q4WT50 Cluster: SIR2 family histone deacetylase (Hst4),
putative; n=7; Trichocomaceae|Rep: SIR2 family histone
deacetylase (Hst4), putative - Aspergillus fumigatus
(Sartorya fumigata)
Length = 614
Score = 63.7 bits (148), Expect = 4e-09
Identities = 43/119 (36%), Positives = 70/119 (58%), Gaps = 6/119 (5%)
Frame = +2
Query: 290 EVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KYEL-PQPQAI 463
+ +D +V+ ++ R +KI+ ++GAGISTSAGIPDFRS + GL+ +LQ K+ L + +
Sbjct: 120 QAQVDLLVKTLR--RHRKIVVIAGAGISTSAGIPDFRSTD-GLFKSLQKKHNLKASGKLL 176
Query: 464 FEINFFRQN--PKPFFTLAKELFPGSFK--PTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
F+ ++ F + + L + K PT H+ + L ++ L R YTQNID +E
Sbjct: 177 FDAAVYQDESLTASFQDMVRSLSEEAAKTCPTAFHHMLARLAQENRLTRLYTQNIDGIE 235
>UniRef50_A6R1B0 Cluster: Predicted protein; n=2; Onygenales|Rep:
Predicted protein - Ajellomyces capsulatus NAm1
Length = 547
Score = 63.7 bits (148), Expect = 4e-09
Identities = 38/103 (36%), Positives = 62/103 (60%), Gaps = 6/103 (5%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQK-YEL-PQPQAIFEINFFRQN--PKPFF 505
+KI+ ++GAGIS SAGIPDFRS GL+ L+K ++L + +F+ + ++ + F
Sbjct: 103 RKIVVIAGAGISVSAGIPDFRSAH-GLFKTLKKDHKLKTSGKQLFDASVYQDDTMTSSFH 161
Query: 506 TLAKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
+ + L S +PT H+ + L + G L+R YTQN+D +E
Sbjct: 162 DMVRSLSGMAASAQPTAFHHLLARLAKDGRLMRLYTQNVDGIE 204
>UniRef50_A4RMS1 Cluster: Putative uncharacterized protein; n=2;
Sordariomycetes|Rep: Putative uncharacterized protein -
Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 666
Score = 63.7 bits (148), Expect = 4e-09
Identities = 39/103 (37%), Positives = 62/103 (60%), Gaps = 4/103 (3%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQN--PKPFFTL 511
K+I+ ++GAGIS SAGIPDFRS ++GL+ + K+ +F+++ + + F +
Sbjct: 140 KRIVIIAGAGISVSAGIPDFRS-QSGLFKSNGKH-------LFDVSVYHDDSLTSAFHKM 191
Query: 512 AKELFPGS--FKPTISHYFIRLLHEKGLLLRHYTQNIDTLERG 634
+EL S PT H+ + + ++G LLR YTQNID L+ G
Sbjct: 192 VRELATKSQAASPTPFHHMMASIAQEGRLLRLYTQNIDCLDTG 234
>UniRef50_UPI000023E2DA Cluster: hypothetical protein FG00460.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG00460.1 - Gibberella zeae PH-1
Length = 607
Score = 63.3 bits (147), Expect = 6e-09
Identities = 38/103 (36%), Positives = 65/103 (63%), Gaps = 6/103 (5%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KYELP-QPQAIFEINFFRQN--PKPFF 505
KKI+ ++GAGIS +AGIPDFRS TGL+ +++ ++ L + +F+ + ++ + + F
Sbjct: 131 KKIVVIAGAGISVAAGIPDFRS-STGLFASVKNQHNLKGSGKHLFDASVYKHDDTTESFH 189
Query: 506 TLAKELF--PGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
+ +E+ S KPT H+ + L +G LLR Y+QNID ++
Sbjct: 190 AMVREMAAKTKSAKPTPFHHLLASLAHEGRLLRLYSQNIDCID 232
>UniRef50_A0LG97 Cluster: Silent information regulator protein Sir2;
n=1; Syntrophobacter fumaroxidans MPOB|Rep: Silent
information regulator protein Sir2 - Syntrophobacter
fumaroxidans (strain DSM 10017 / MPOB)
Length = 248
Score = 62.5 bits (145), Expect = 1e-08
Identities = 42/123 (34%), Positives = 65/123 (52%), Gaps = 2/123 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R + + L+GAGIS +GIPDFRS + GL+ KY+ P I FR NP +T+
Sbjct: 13 RSRYTVVLTGAGISVESGIPDFRSKD-GLW---SKYD---PAEYGYIGSFRANPAKVWTM 65
Query: 512 AKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
E+ +P +H + L ++G++ TQNID+L + AG + ++E HG +
Sbjct: 66 LTEMDAVLRQARPNFAHLALADLEKRGIVKELVTQNIDSLHQRAG--SKNVIEFHGHNRS 123
Query: 686 SHC 694
C
Sbjct: 124 LRC 126
>UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC
SILENCING; n=1; Encephalitozoon cuniculi|Rep: SIR2-LIKE
PROTEIN INVOLVED IN TELOMERIC SILENCING -
Encephalitozoon cuniculi
Length = 425
Score = 62.5 bits (145), Expect = 1e-08
Identities = 43/135 (31%), Positives = 71/135 (52%), Gaps = 9/135 (6%)
Frame = +2
Query: 320 IKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIF--EINFFRQNP 493
IK ++++ ++GAGIS S+GIPDFRS ++GL+++++K +F ++ ++
Sbjct: 80 IKMFAKRRVVVITGAGISVSSGIPDFRS-KSGLFNDIKKDLGVSGNDLFTYSLSMSKELR 138
Query: 494 KPFFTLAKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK---- 655
K + +L +P+ +H F+ L + R YTQNID LE AG+ K
Sbjct: 139 KGYLRYISKLKNMVDKAQPSATHEFLSLYSDISRRFRIYTQNIDGLEEKAGLAATKDRST 198
Query: 656 -LVEAHGTFYTSHCL 697
LV HG + CL
Sbjct: 199 RLVYLHGNMKSLGCL 213
>UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=7;
cellular organisms|Rep: NAD-dependent deacetylase
sirtuin-4 - Mus musculus (Mouse)
Length = 333
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/148 (31%), Positives = 71/148 (47%), Gaps = 4/148 (2%)
Frame = +2
Query: 269 PPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELP 448
PP LD + + R+I KK++ ++GAGIST + IPD+RS + GLY +
Sbjct: 31 PPSPPLDPEKIKELQRFISLS--KKLLVMTGAGISTESSIPDYRSEKVGLYARTDR---- 84
Query: 449 QPQAIFEINFFRQNPKPFFTLAKEL--FP--GSFKPTISHYFIRLLHEKGLLLRHYTQNI 616
+ I I+F R P A+ +P S +P +H+ + G L TQN+
Sbjct: 85 --RPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKLHWLVTQNV 142
Query: 617 DTLERGAGIPEEKLVEAHGTFYTSHCLD 700
D L AG ++L E HG + CL+
Sbjct: 143 DALHSKAG--SQRLTELHGCMHRVLCLN 168
>UniRef50_A0NQ49 Cluster: Silent information regulator protein Sir2;
n=1; Stappia aggregata IAM 12614|Rep: Silent information
regulator protein Sir2 - Stappia aggregata IAM 12614
Length = 260
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/123 (31%), Positives = 67/123 (54%), Gaps = 3/123 (2%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQ--KYELPQPQAIFEINFFRQNPKPFFTL 511
++I+ L+GAGIST +GIPDFRSP G++ Q +Y+ + + + + +
Sbjct: 23 RQIVALTGAGISTESGIPDFRSPG-GIWSKRQPVQYQDFVDDEDSRLEDWDRRLEDWDRR 81
Query: 512 AKEL-FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
++ + + +P +H+ + L G L+ TQN+D L + AG P++ LVE HG +
Sbjct: 82 SEMMDYFCKAEPNAAHFALTTLARSGKLVCLITQNVDGLHQRAGFPDDLLVEIHGNSTFA 141
Query: 689 HCL 697
CL
Sbjct: 142 SCL 144
>UniRef50_A6PTK3 Cluster: Silent information regulator protein Sir2;
n=1; Victivallis vadensis ATCC BAA-548|Rep: Silent
information regulator protein Sir2 - Victivallis
vadensis ATCC BAA-548
Length = 248
Score = 61.7 bits (143), Expect = 2e-08
Identities = 42/122 (34%), Positives = 60/122 (49%), Gaps = 2/122 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
++ + +GAGIST +GI DFR + G+Y L+ + + I ++ F P F+ A
Sbjct: 13 RRTLAFTGAGISTLSGIRDFRG-KNGVY--LEPWHGKSVEEILSLDCFLAEPALFYGWAA 69
Query: 518 ELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
E F P H + L + GLL YTQNID L + AG + E HG+ H
Sbjct: 70 EFLYRLEEFHPAAVHRALAGLEQSGLLRGVYTQNIDLLHQQAG--SRHVYELHGSPARHH 127
Query: 692 CL 697
CL
Sbjct: 128 CL 129
>UniRef50_Q4P2A5 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 1036
Score = 61.3 bits (142), Expect = 2e-08
Identities = 52/151 (34%), Positives = 73/151 (48%), Gaps = 10/151 (6%)
Frame = +2
Query: 221 ALKLGLFSPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSA--GIPD 394
ALK L + P P K +D L + + R +I + GAGIS SA IPD
Sbjct: 94 ALKYDLPADITAPPFAQPSKDVDR-DLARLYEAVSGAR--RIAVICGAGISVSAPANIPD 150
Query: 395 FRSPETGLYHNLQKYE----LPQPQAIFEINFFRQNPKP--FFTLAKEL--FPGSFKPTI 550
FRS GL+ L++ L + +F+ F F+++ EL +PTI
Sbjct: 151 FRSAH-GLFKKLKEKHPTAGLSSGKDLFDARLFSSESTSALFYSMVAELKRLADEAEPTI 209
Query: 551 SHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
H F++ L ++G L R YTQNID LE AG+
Sbjct: 210 FHRFLKRLDDEGRLQRVYTQNIDGLEEKAGL 240
>UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3;
Fusobacterium nucleatum|Rep: NAD-dependent deacetylase -
Fusobacterium nucleatum subsp. nucleatum
Length = 252
Score = 61.3 bits (142), Expect = 2e-08
Identities = 45/138 (32%), Positives = 72/138 (52%), Gaps = 1/138 (0%)
Frame = +2
Query: 287 DEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIF 466
DE L+ +V+ +K+ K ++ GAG ST +G+ DFR + GLY L K + +P+ +
Sbjct: 6 DEKILE-LVKILKNT--KYLVFFGGAGTSTDSGVKDFRGKD-GLYKTLYK-DKYRPEEVL 60
Query: 467 EINFFRQNPKPFFT-LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
+FF + F + KEL KP H + L + G+L TQNID L + +G
Sbjct: 61 SSDFFYSHRDIFMKYVEKELNIKGLKPNKGHMALVELEKIGILKAVITQNIDDLHQVSG- 119
Query: 644 PEEKLVEAHGTFYTSHCL 697
+ ++E HG+ +CL
Sbjct: 120 -NKNVLELHGSLKRWYCL 136
>UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=3; Leuconostocaceae|Rep: NAD-dependent protein
deacetylase, SIR2 family - Leuconostoc mesenteroides
subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 234
Score = 60.5 bits (140), Expect = 4e-08
Identities = 40/120 (33%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNP-KPF- 502
D K I+ ++GAG+ST +GIPD+RS + G+Y + QP+ + F P K +
Sbjct: 12 DNAKNIVFMTGAGVSTLSGIPDYRS-KGGIYDGISL----QPEYLLSATAFHNEPEKQYQ 66
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
F + FP + P + H + L +G + TQN+D L A EKL+ HG+ Y
Sbjct: 67 FMIDNMYFPEAV-PNVIHKKMAALTRQG-KAKIITQNVDDLHVKAASDPEKLIRFHGSLY 124
>UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=23;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-4 -
Homo sapiens (Human)
Length = 314
Score = 60.1 bits (139), Expect = 5e-08
Identities = 44/147 (29%), Positives = 68/147 (46%)
Frame = +2
Query: 260 PAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKY 439
PA PP LD + + R+I K+++ ++GAGIST +GIPD+RS + GLY +
Sbjct: 34 PASPP---LDPEKVKELQRFITLS--KRLLVMTGAGISTESGIPDYRSEKVGLYARTDRR 88
Query: 440 ELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNID 619
+ + ++ F + S +P +H+ + + G L TQN+D
Sbjct: 89 PIQHGDFVRSAPIRQRYWARNFVGWPQF--SSHQPNPAHWALSTWEKLGKLYWLVTQNVD 146
Query: 620 TLERGAGIPEEKLVEAHGTFYTSHCLD 700
L AG +L E HG CLD
Sbjct: 147 ALHTKAG--SRRLTELHGCMDRVLCLD 171
>UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4;
Leptospira|Rep: NAD-dependent deacetylase - Leptospira
interrogans
Length = 246
Score = 59.7 bits (138), Expect = 7e-08
Identities = 43/125 (34%), Positives = 62/125 (49%), Gaps = 2/125 (1%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT 508
D+ +KI +SGAGIS +GIP FR E GL+ N + +L PQA F +NPK +
Sbjct: 10 DKFQKISAISGAGISAESGIPTFRGSE-GLWKNFRAEDLATPQA------FSKNPKLVWE 62
Query: 509 --LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
L + + +P H+ + L TQN+D L AG +KL E HG +
Sbjct: 63 WYLWRRNIIETKRPNPGHFALVELERIHPDFFLITQNVDGLHSQAG--SKKLTEIHGNIF 120
Query: 683 TSHCL 697
+ C+
Sbjct: 121 INRCI 125
>UniRef50_Q5KG84 Cluster: Hst4 protein, putative; n=2;
Filobasidiella neoformans|Rep: Hst4 protein, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 478
Score = 54.4 bits (125), Expect(2) = 7e-08
Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 5/107 (4%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQK-----YELPQPQAIFEINFFRQNPKPF 502
K+I+ +SGAG+ST A IPDFRS +GL+ K +L + + ++ +
Sbjct: 44 KRIVVVSGAGVSTGAAIPDFRS-ASGLFSGKTKGGHSVKDLFHVRCLAHPTLLAKHHELI 102
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
+L+ + PT H ++ L +G LLR YTQNID LE G+
Sbjct: 103 TSLSS--LSTAAPPTPFHTYLSSLDNEGRLLRCYTQNIDGLEEKTGL 147
Score = 25.0 bits (52), Expect(2) = 7e-08
Identities = 10/26 (38%), Positives = 13/26 (50%)
Frame = +2
Query: 617 DTLERGAGIPEEKLVEAHGTFYTSHC 694
DT E PE +++ HG T HC
Sbjct: 175 DTPETSLEPPEPRVIPLHGLLSTLHC 200
>UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3;
Actinomycetales|Rep: NAD-dependent deacetylase 2 -
Streptomyces coelicolor
Length = 241
Score = 58.8 bits (136), Expect = 1e-07
Identities = 34/114 (29%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNP---KPFFTLA 514
+ LSGAG+ST +GIPD+R P GL+ P+ + + ++ +P + + +
Sbjct: 7 VAILSGAGVSTDSGIPDYRGPN-GLWRRD-----PEAEKLVTYEYYMGDPEIRRRSWLMR 60
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGT 676
++ +P +H + L +G+ +R TQN+D L + AG+ K++E HGT
Sbjct: 61 RDSAALHAEPNAAHRAVADLERRGVPVRVLTQNVDGLHQLAGVSARKVLELHGT 114
>UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4;
Pseudomonas|Rep: NAD-dependent deacetylase 2 -
Pseudomonas syringae pv. tomato
Length = 248
Score = 58.8 bits (136), Expect = 1e-07
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 2/121 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
K+I+ ++GAG+S +G+P +R GLY+ + LP A+ R++P+ +
Sbjct: 12 KRILVITGAGLSADSGLPTYRGVG-GLYNGETEDGLPIEMALSG-PMLRRDPELCWKYIA 69
Query: 518 ELFPGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
EL +P ++HY I L TQN+D R AG P E+L+E HG
Sbjct: 70 ELGKACLGGEPNVAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEIHGQLSPLF 129
Query: 692 C 694
C
Sbjct: 130 C 130
>UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 343
Score = 58.4 bits (135), Expect = 2e-07
Identities = 42/121 (34%), Positives = 61/121 (50%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
+ K ++ +GAGISTS GIPDFR P+ G++ LQ+ PQA + F R
Sbjct: 74 KSKHLVVFTGAGISTSCGIPDFRGPK-GIW-TLQREGKALPQA--SLPFHRA-------- 121
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
P+++H + L + G+L +QNID L +GIP +KL E HG +
Sbjct: 122 ---------MPSMTHMALVELEKAGILKFVISQNIDGLHLRSGIPRDKLAELHGNSFMEI 172
Query: 692 C 694
C
Sbjct: 173 C 173
>UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin
regulatory protein sir2; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to chromatin regulatory protein sir2
- Nasonia vitripennis
Length = 736
Score = 58.0 bits (134), Expect = 2e-07
Identities = 37/121 (30%), Positives = 63/121 (52%), Gaps = 2/121 (1%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
KI ++GAGIST +GIPD+RS GL+ + +P + + + + ++
Sbjct: 476 KICVITGAGISTESGIPDYRSEGVGLFATSDR----RPVSYQDFCKSDKTRRRYWARNYA 531
Query: 521 LFP--GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+P F+P ++H +++ + + G + TQN+D L AG + +VE HGT Y C
Sbjct: 532 AWPRFSLFQPNVTHKWLKNMEDIGKVSCVITQNVDNLHIKAG--SKNVVELHGTGYRVVC 589
Query: 695 L 697
L
Sbjct: 590 L 590
>UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6;
Corynebacterium|Rep: NAD-dependent deacetylase 1 -
Corynebacterium efficiens
Length = 281
Score = 58.0 bits (134), Expect = 2e-07
Identities = 46/139 (33%), Positives = 66/139 (47%), Gaps = 5/139 (3%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEIN 475
+L+G+V+ +++ ++ ++GAG+ST +GIPD+RSP L +P E
Sbjct: 6 ALEGVVKLLEAG---SVLAVTGAGVSTDSGIPDYRSPRGSLNQG-------RPMTYQE-- 53
Query: 476 FFRQNPKPFFTLAKELFPG-----SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAG 640
FR +P F G +P +HY + L GLL TQN+D L R AG
Sbjct: 54 -FRFDPVASHRYWARSFVGWRVMADAQPNRTHYALVELERAGLLSGIVTQNVDGLHRRAG 112
Query: 641 IPEEKLVEAHGTFYTSHCL 697
E LV HG T CL
Sbjct: 113 --SENLVALHGDLATIVCL 129
>UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 273
Score = 57.6 bits (133), Expect = 3e-07
Identities = 43/128 (33%), Positives = 64/128 (50%), Gaps = 7/128 (5%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK---PF 502
+ K I+ L+GAGIS +GIP FR GL+ +L P A F NP F
Sbjct: 24 KAKNILFLTGAGISAESGIPTFRG-AGGLWRTFSATDLATPGA------FHTNPSLVWEF 76
Query: 503 FTLAKELFPGSFKPTISHY----FIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAH 670
++ +E+ S KP +H+ F + + +G + TQNID L + AG E ++E H
Sbjct: 77 YSYRREVVL-SKKPNPAHFAIAEFQKKMRNEGKQVWVVTQNIDELHKTAG--AEDVIELH 133
Query: 671 GTFYTSHC 694
GT + + C
Sbjct: 134 GTLFKTRC 141
>UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140
chromosome D of strain NRRL Y- 1140 of Kluyveromyces
lactis; n=1; Kluyveromyces lactis|Rep: Kluyveromyces
lactis strain NRRL Y-1140 chromosome D of strain NRRL Y-
1140 of Kluyveromyces lactis - Kluyveromyces lactis
(Yeast) (Candida sphaerica)
Length = 399
Score = 57.6 bits (133), Expect = 3e-07
Identities = 45/134 (33%), Positives = 67/134 (50%), Gaps = 14/134 (10%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKY--ELPQPQAIFEIN-FFRQNPK--PF 502
K+I+ + GAG+S +AGIPDFRS GL+ L+ + + +F+ N + N F
Sbjct: 113 KRIVVVQGAGVSVAAGIPDFRS-ANGLFTTLKSSSPNVKSGKDLFDFNHVYSSNSMSISF 171
Query: 503 FTLAKELFPGS--FKPTISHYFIRLLHEKGLLLRHYTQNIDTLE-------RGAGIPEEK 655
+L +L S KPT H FI L EK + R Y+QNID LE +
Sbjct: 172 NSLMSKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQ 231
Query: 656 LVEAHGTFYTSHCL 697
+V+ HG+ + C+
Sbjct: 232 VVQLHGSIHHMSCM 245
>UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida
albicans; n=2; Saccharomycetaceae|Rep: Similar to
CA4170|IPF7784 Candida albicans - Debaryomyces hansenii
(Yeast) (Torulaspora hansenii)
Length = 301
Score = 57.6 bits (133), Expect = 3e-07
Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 2/123 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIF-EINFFRQNPKPFFT 508
+ K+I+ L GAG+S S+G+P FR + GL+ N +L P A + + Q F
Sbjct: 14 KSKRIVALVGAGLSVSSGLPTFRGSQ-GLWKNFNMIDLATPDAFYIDPGLVWQ-----FY 67
Query: 509 LAKELFPGSFKPTISHYFIRLLHE-KGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
+ + KP H + L + + TQN+D L AG P+EKL E HG+ +
Sbjct: 68 SWRRINASKAKPNKGHLALAKLSKLSNIEFMTITQNVDGLLIRAGHPKEKLHEIHGSLFD 127
Query: 686 SHC 694
C
Sbjct: 128 LRC 130
>UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 251
Score = 57.2 bits (132), Expect = 4e-07
Identities = 40/129 (31%), Positives = 63/129 (48%)
Frame = +2
Query: 308 IVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQ 487
+ WI + + GAG+ST +GIPDFR G Y Q+ E+P + + I+FF +
Sbjct: 8 LAAWIAAS--PSTVFFGGAGVSTESGIPDFRG-ANGFY--FQEREIPL-ETVLSIDFFER 61
Query: 488 NPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEA 667
+P+ ++ E++ +P +H + L G L TQNID L + AG + E
Sbjct: 62 HPQAYWEWFHEIY-RPVEPNGAHRALASLEAAGRLDAVITQNIDGLHQRAG--SRAVWEL 118
Query: 668 HGTFYTSHC 694
HG + C
Sbjct: 119 HGNWERLVC 127
>UniRef50_Q6CB00 Cluster: Similarities with tr|Q9UR39
Schizosaccharomyces pombe HST4P; n=1; Yarrowia
lipolytica|Rep: Similarities with tr|Q9UR39
Schizosaccharomyces pombe HST4P - Yarrowia lipolytica
(Candida lipolytica)
Length = 721
Score = 57.2 bits (132), Expect = 4e-07
Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 15/135 (11%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KYELPQP-QAIFEINFFRQ--NPKPFF 505
++++ ++GAGIS AGIPDFRS + GL+ +L+ +Y L +A+F+ + FR+ F
Sbjct: 176 QRLVVITGAGISVHAGIPDFRS-DKGLFVSLKDEYNLKTTGKALFDASVFREPATTMHFH 234
Query: 506 TLAKEL--FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLER-----GAGIPEEK--- 655
+ L K T H+F+ + E+ L R Y+QNID L+ +P +K
Sbjct: 235 SAINGLQKLCQDAKHTPFHHFLNSISEQNRLARLYSQNIDCLDTSLPHLSTSVPLQKPWP 294
Query: 656 -LVEAHGTFYTSHCL 697
V+ HG+ +C+
Sbjct: 295 TTVQLHGSISKMNCM 309
>UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Pyrococcus
furiosus
Length = 250
Score = 57.2 bits (132), Expect = 4e-07
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 2/118 (1%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELF 526
I +GAGIS +GIP FR + GL+ + EL P+A F+++PK + K
Sbjct: 16 IAFTGAGISAESGIPTFRGKD-GLWRKYRAEELATPEA------FKRDPKLVWEFYKWRI 68
Query: 527 PGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
KP +H + L + G++ TQN+D L R AG + ++E HG + C
Sbjct: 69 KKILEAKPNPAHIALAELEKMGIIKAVITQNVDDLHREAG--SKNVIELHGNIFRVKC 124
>UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|Rep:
Sir2-like protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 473
Score = 56.4 bits (130), Expect = 6e-07
Identities = 41/121 (33%), Positives = 60/121 (49%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
+ K ++ +GAGISTS GIPDFR P+ G++ LQ+ P+A + F R
Sbjct: 43 KSKHLVVFTGAGISTSCGIPDFRGPK-GIW-TLQREGKDLPKA--SLPFHRA-------- 90
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
P+++H + L G+L +QN+D L +GIP EKL E HG +
Sbjct: 91 ---------MPSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEM 141
Query: 692 C 694
C
Sbjct: 142 C 142
>UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 320
Score = 56.4 bits (130), Expect = 6e-07
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 1/121 (0%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFR-QNPKPFFTLA 514
+K+ LSGAG+ST +GIPD+RS + GLY + + + + + + A
Sbjct: 63 RKLFVLSGAGLSTESGIPDYRSKDVGLYARTNHKPMQHQDFVKSADKRKIYWARSYLGWA 122
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
K ++KP +H + + + G + H TQN+D L AG E+L E HG C
Sbjct: 123 KY---NAWKPNAAHVKLAAMEKDGRVDWHTTQNVDGLMVKAG--AEQLTELHGQMRRVVC 177
Query: 695 L 697
+
Sbjct: 178 M 178
>UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces
hansenii IPF 2468.1; n=2; Ascomycota|Rep: Similar to
DEHA0C01507g Debaryomyces hansenii IPF 2468.1 - Yarrowia
lipolytica (Candida lipolytica)
Length = 303
Score = 56.4 bits (130), Expect = 6e-07
Identities = 41/123 (33%), Positives = 58/123 (47%), Gaps = 4/123 (3%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTL 511
+KI+ L GAG+S S+G+P FR E G++ N EL P+A F +P F
Sbjct: 17 RKILALVGAGLSQSSGLPTFRG-EGGIWRNYDAAELATPEA------FHNDPSTVWQFYA 69
Query: 512 AKELFPGSFKPTISHYFIRLLHE--KGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
+ KP HY + L +G L TQN+D L A P+E L++ HG +
Sbjct: 70 HRRHMSLKAKPNPGHYALAELARRLRGRFLT-LTQNVDGLSSRAEHPQEALLKLHGDLFA 128
Query: 686 SHC 694
C
Sbjct: 129 LKC 131
>UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 278
Score = 55.6 bits (128), Expect = 1e-06
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 6/124 (4%)
Frame = +2
Query: 341 KIIT-LSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTL 511
K+IT L+GAGIS +G+P +R + + Y+ P+ + FF++NP F L
Sbjct: 20 KLITFLTGAGISAESGVPTYRGTDGIWVEGSRNYK---PEEFATLRFFKENPAEVWKFVL 76
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHY---TQNIDTLERGAGIPEEKLVEAHGTFY 682
+++ +P H + L + LL ++ TQNID L AG + K++E HG
Sbjct: 77 YRKVSFRDLQPNAGH--LALASTEVLLPNNFRLITQNIDRLHIKAGNTQAKVLEIHGNME 134
Query: 683 TSHC 694
T C
Sbjct: 135 TVRC 138
>UniRef50_Q7R0R8 Cluster: GLP_79_6121_4343; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_79_6121_4343 - Giardia lamblia ATCC
50803
Length = 592
Score = 55.6 bits (128), Expect = 1e-06
Identities = 43/134 (32%), Positives = 70/134 (52%), Gaps = 22/134 (16%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGL-----YHNLQKYELPQPQAI-FEINFFR------ 484
K + GAG+ST+ G+ FRS + ++ L Y L Q A + +FF
Sbjct: 75 KAYCILGAGVSTAVGLSAFRSSGSIFRRVQHFYPLLVYALQQEVADPSDDDFFLRYALGL 134
Query: 485 ----QNPKPFFTLAKE-----LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGA 637
QNP +++ +E +F + +P+++HYF+R L ++G+L TQNID LERG
Sbjct: 135 RGIIQNPIVVYSVLREYHESIMFISNIRPSLTHYFLRFLADEGILKLILTQNIDELERGV 194
Query: 638 GIPE-EKLVEAHGT 676
G+ E + + HG+
Sbjct: 195 GLSEVVDVKQVHGS 208
>UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12;
Proteobacteria|Rep: NAD-dependent deacetylase 1 -
Bradyrhizobium japonicum
Length = 254
Score = 55.6 bits (128), Expect = 1e-06
Identities = 37/120 (30%), Positives = 60/120 (50%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
K I+ +GAGIST GIPDFRSP G++ + +P + ++ + F + +
Sbjct: 23 KTIVPFTGAGISTECGIPDFRSP-GGIW--TRNRPIPFDGFVASQEARDESWRRRFAM-E 78
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
E F + +P H + L+ G + TQNID L + +G E ++E HG + C+
Sbjct: 79 ETFAAA-RPGRGHRALASLYRAGKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYARCV 137
>UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=6; Lactobacillus|Rep: NAD-dependent protein
deacetylase, SIR2 family - Lactobacillus gasseri (strain
ATCC 33323 / DSM 20243)
Length = 237
Score = 55.2 bits (127), Expect = 1e-06
Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 2/116 (1%)
Frame = +2
Query: 353 LSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK-PFFTLAKELFP 529
L+GAG+ST + IPD+RS + G+Y+ + E P+ Q + E F + K F + FP
Sbjct: 23 LTGAGVSTPSHIPDYRS-KNGIYNGIS--ESPE-QILSEDTLFHEPAKFHHFVMENMYFP 78
Query: 530 GSFKPTISHYFIRL-LHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+ +P I H I ++ G L+ TQN+D L++ AG + ++E HG Y C
Sbjct: 79 NA-QPNIIHQKIAASCNKNGTLI---TQNVDGLDKKAG--NKHVIEFHGNLYNIFC 128
>UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6;
Pseudomonadaceae|Rep: NAD-dependent deacetylase 2 -
Pseudomonas aeruginosa
Length = 256
Score = 55.2 bits (127), Expect = 1e-06
Identities = 38/123 (30%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R ++I+ ++GAG+S +G+P +R GLY+ + LP +A R++P +
Sbjct: 16 RAERILVITGAGLSADSGMPTYRGLG-GLYNGRTEEGLPI-EAALSGPMLRRDPALCWKY 73
Query: 512 AKELFPGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
EL +P H I L + TQNID R AG P E+L+E HG
Sbjct: 74 LAELGKACLAARPNAGHEAIAELQKHKPECWVLTQNIDGFHRQAGSPAERLIEIHGELAP 133
Query: 686 SHC 694
+C
Sbjct: 134 LYC 136
>UniRef50_Q3E2I1 Cluster: Silent information regulator protein Sir2;
n=7; Bacteria|Rep: Silent information regulator protein
Sir2 - Chloroflexus aurantiacus J-10-fl
Length = 254
Score = 54.8 bits (126), Expect = 2e-06
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 2/121 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT--L 511
+ + L+GAG+S +GIP FR +TGL+ + EL P F +NP +
Sbjct: 19 RHVTVLTGAGVSAESGIPTFRDAQTGLWSHFDPEELASPAG------FARNPALVWRWYA 72
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
+ + + +P +H+ + L L TQNID L + AG P+ ++E HG + +
Sbjct: 73 ERRVKACTAQPNPAHHALADLATLVPRLTLVTQNIDGLHQRAGSPQ--VIELHGNIHRAR 130
Query: 692 C 694
C
Sbjct: 131 C 131
>UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellular
organisms|Rep: NAD-dependent deacetylase 2 - Pyrobaculum
aerophilum
Length = 249
Score = 54.8 bits (126), Expect = 2e-06
Identities = 37/120 (30%), Positives = 62/120 (51%), Gaps = 3/120 (2%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK---PFFTLAK 517
+ +GAGIS +G+P FR P GL+ + EL P+A F ++P ++ +
Sbjct: 14 VVFTGAGISAESGVPTFRGP-GGLWERYKPEELATPEA------FARDPALVWRWYKWRQ 66
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
E+ + +P+ HY I L G++ TQN+D L + AG +VE HG+ + + C+
Sbjct: 67 EVIYNA-RPSPGHYAIAELEAMGVVRGVITQNVDGLHQRAG--SRLVVELHGSIWRARCV 123
>UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025231 - Anopheles gambiae
str. PEST
Length = 182
Score = 54.4 bits (125), Expect = 3e-06
Identities = 36/112 (32%), Positives = 55/112 (49%), Gaps = 1/112 (0%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAI-FEINFFRQNPKPFFTLAKE 520
I+ L+GAGIST +GIPD+RS GLY + + E R + + K
Sbjct: 1 ILVLTGAGISTESGIPDYRSEGVGLYARSNHKPIQHGDFVKSEATRKRYWARNYVGWPKF 60
Query: 521 LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGT 676
S P ++HY + L +G + TQN+D L AG ++++E HG+
Sbjct: 61 ---SSIAPNVTHYTLARLEREGRISGIVTQNVDRLHGKAG--SKQVIELHGS 107
>UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=28;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-5 -
Homo sapiens (Human)
Length = 310
Score = 54.4 bits (125), Expect = 3e-06
Identities = 42/128 (32%), Positives = 62/128 (48%), Gaps = 7/128 (5%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK---PF 502
+ K I+ +SGAG+S +G+P FR G + Q +L P A F NP F
Sbjct: 49 KAKHIVIISGAGVSAESGVPTFRG-AGGYWRKWQAQDLATPLA------FAHNPSRVWEF 101
Query: 503 FTLAKELFPGSFKPTISHYFI----RLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAH 670
+ +E+ GS +P H I L ++G + TQNID L R AG + L+E H
Sbjct: 102 YHYRREVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAG--TKNLLEIH 158
Query: 671 GTFYTSHC 694
G+ + + C
Sbjct: 159 GSLFKTRC 166
>UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4
CG3187-PC, isoform C isoform 2; n=2; Endopterygota|Rep:
PREDICTED: similar to Sirt4 CG3187-PC, isoform C isoform
2 - Apis mellifera
Length = 302
Score = 54.0 bits (124), Expect = 3e-06
Identities = 39/124 (31%), Positives = 57/124 (45%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT 508
D I L+GAGIST +GIPD+RS GLY ++ + + R+
Sbjct: 38 DSHDNICVLTGAGISTESGIPDYRSEGVGLYAR-SNHKPVLYKDFCNSDAIRRRYWARNY 96
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
+ F S KP +H + L + TQN+D L AG +K++E HGT +
Sbjct: 97 IGWPRF-SSIKPNNTHKILTKLENANKIRYIITQNVDNLHTKAG--SKKVIELHGTAFRV 153
Query: 689 HCLD 700
CL+
Sbjct: 154 MCLN 157
>UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5;
Catarrhini|Rep: Isoform 2 of Q8N6T7 - Homo sapiens
(Human)
Length = 328
Score = 54.0 bits (124), Expect = 3e-06
Identities = 43/143 (30%), Positives = 66/143 (46%)
Frame = +2
Query: 266 EPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYEL 445
+PPE++ +V + W S ++ +GAGIST++GIPDFR P G++ ++
Sbjct: 25 DPPEELERKVWELARLVWQSSS----VVFHTGAGISTASGIPDFRGPH-GVWTMEERGLA 79
Query: 446 PQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTL 625
P+ FE S +PT +H + L GLL +QN+D L
Sbjct: 80 PKFDTTFE---------------------SARPTQTHMALVQLERVGLLRFLVSQNVDGL 118
Query: 626 ERGAGIPEEKLVEAHGTFYTSHC 694
+G P +KL E HG + C
Sbjct: 119 HVRSGFPRDKLAELHGNMFVEEC 141
>UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: NAD-dependent
deacetylase - Candidatus Desulfococcus oleovorans Hxd3
Length = 273
Score = 54.0 bits (124), Expect = 3e-06
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Frame = +2
Query: 356 SGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFP-- 529
SGAG+S +GIP FR P G++ L E+ Q + + +NP+ + EL
Sbjct: 24 SGAGVSAESGIPTFRDP-GGVWDRLNPAEVGDTQGL--LASLEKNPEKLVAMFMELLAVF 80
Query: 530 GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+ P H + L G+L TQNID L + AG +++E HG + CL
Sbjct: 81 DAAIPNPGHRALFDLERMGILQAVITQNIDNLHQEAG--NTQVIEMHGNGFRFRCL 134
>UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6;
n=22; Euteleostomi|Rep: Mono-ADP-ribosyltransferase
sirtuin-6 - Homo sapiens (Human)
Length = 355
Score = 54.0 bits (124), Expect = 3e-06
Identities = 43/143 (30%), Positives = 66/143 (46%)
Frame = +2
Query: 266 EPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYEL 445
+PPE++ +V + W S ++ +GAGIST++GIPDFR P G++ ++
Sbjct: 25 DPPEELERKVWELARLVWQSSS----VVFHTGAGISTASGIPDFRGPH-GVWTMEERGLA 79
Query: 446 PQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTL 625
P+ FE S +PT +H + L GLL +QN+D L
Sbjct: 80 PKFDTTFE---------------------SARPTQTHMALVQLERVGLLRFLVSQNVDGL 118
Query: 626 ERGAGIPEEKLVEAHGTFYTSHC 694
+G P +KL E HG + C
Sbjct: 119 HVRSGFPRDKLAELHGNMFVEEC 141
>UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9;
Bacteria|Rep: NAD-dependent deacetylase - Pseudomonas
putida (strain KT2440)
Length = 262
Score = 54.0 bits (124), Expect = 3e-06
Identities = 41/123 (33%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT- 508
R K ++ +GAGIS +GIP FR TGL+ K++ PQ + + FR NP ++
Sbjct: 13 RSKTVVFFTGAGISADSGIPTFRDKLTGLW---AKHD---PQRLETADAFRANPTLVWSW 66
Query: 509 -LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
L + KP +H I L + G + TQNID L AG +V HG+
Sbjct: 67 YLWRRHQVSQAKPNSAHLSIPQLADAGWDVSVVTQNIDDLHERAG--SSPVVHLHGSLMD 124
Query: 686 SHC 694
C
Sbjct: 125 VKC 127
>UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4;
Lactobacillus|Rep: NAD-dependent deacetylase -
Lactobacillus plantarum
Length = 234
Score = 54.0 bits (124), Expect = 3e-06
Identities = 41/124 (33%), Positives = 63/124 (50%), Gaps = 3/124 (2%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLY--HNLQKYELPQPQAIFEINFFRQNPKPFF 505
+ + I+ ++GAG+ST +GIPD+RS + GLY H+ +Y L F ++P F+
Sbjct: 13 QAQHIVFMTGAGVSTPSGIPDYRS-KNGLYTEHHNAEYYLSHA-------FLAEHPLEFY 64
Query: 506 T-LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
L L+ +P + H + L ++G TQNID L A +LVE HG Y
Sbjct: 65 QYLQSNLYYPDAQPNVIHQKMAALTQQG-RASVITQNIDNLYGVA--KTAQLVEFHGNLY 121
Query: 683 TSHC 694
+C
Sbjct: 122 QVYC 125
>UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetylase;
n=2; Syntrophus aciditrophicus SB|Rep: Sir2 family of
NAD+-dependent deacetylase - Syntrophus aciditrophicus
(strain SB)
Length = 271
Score = 53.6 bits (123), Expect = 4e-06
Identities = 38/119 (31%), Positives = 55/119 (46%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
+++ +GAG+ST +GIPDFRSP GL+ + + + R K + L
Sbjct: 27 RVVVFTGAGVSTESGIPDFRSP-GGLWDRFDPDDFTIGKFLRSAQTRR---KQWRILIAG 82
Query: 521 LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+P +H + L + G L TQNID L + AG EK+ E HG CL
Sbjct: 83 GALAEAQPNRAHLAVAELEKIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCL 141
>UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 323
Score = 53.6 bits (123), Expect = 4e-06
Identities = 39/123 (31%), Positives = 60/123 (48%), Gaps = 4/123 (3%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLY----HNLQKYELPQPQAIFEINFFRQNPKPFFT 508
KI ++GAGIST +GI D+RS GLY +Y++ A+ ++ +N +
Sbjct: 62 KIFVITGAGISTESGIRDYRSEGKGLYAITNDRPMEYQVFLKSAVMRQRYWARN----YV 117
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
E GS +P +HY + L G + TQN+D L AG + ++E HG +
Sbjct: 118 GWPEF--GSRQPNEAHYALAKLETLGSVHSLVTQNVDALHTKAG--SKNVIELHGCSHRV 173
Query: 689 HCL 697
CL
Sbjct: 174 ICL 176
>UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1;
Nocardia farcinica|Rep: Putative Sir2 family regulator -
Nocardia farcinica
Length = 248
Score = 53.2 bits (122), Expect = 6e-06
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 1/123 (0%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R +I L+GAGIST +GIPDFR P G++ EL + ++ + + L
Sbjct: 8 RSGRIGVLTGAGISTDSGIPDFRGPR-GVWTEDPIAEL---MSTYDQYLSDPDLRRRSWL 63
Query: 512 AKELFPG-SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
A+ P +P H + L G + TQN+D L + AG +++VE HG +
Sbjct: 64 ARRANPAWQAEPNAGHLALVDLERAGRAVTIITQNVDRLHQRAGSSPQRVVEIHGNMFEV 123
Query: 689 HCL 697
C+
Sbjct: 124 VCV 126
>UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-PA -
Drosophila melanogaster (Fruit fly)
Length = 317
Score = 53.2 bits (122), Expect = 6e-06
Identities = 40/117 (34%), Positives = 56/117 (47%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKEL 523
++ +GAGISTSAGIPDFR P+ G++ +K E P F ++F
Sbjct: 47 VVLHTGAGISTSAGIPDFRGPK-GVWTLEEKGEKPD----FNVSF--------------- 86
Query: 524 FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+PT +H I L E G + +QNID L +G+ + L E HG Y C
Sbjct: 87 --DEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQC 141
>UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=24;
Eumetazoa|Rep: NAD-dependent deacetylase sirtuin-7 -
Homo sapiens (Human)
Length = 400
Score = 53.2 bits (122), Expect = 6e-06
Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Frame = +2
Query: 275 EKVLDEVS-LDGIVRWIKSD--RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYEL 445
E+V D+ L G VR + S K ++ +GAGIST+A IPD+R P G++ LQK
Sbjct: 76 EEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPN-GVWTLLQKGRS 134
Query: 446 PQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTL 625
+ E +PT++H I LHE+ L+ +QN D L
Sbjct: 135 VSAADLSEA----------------------EPTLTHMSITRLHEQKLVQHVVSQNCDGL 172
Query: 626 ERGAGIPEEKLVEAHGTFYTSHC 694
+G+P + E HG Y C
Sbjct: 173 HLRSGLPRTAISELHGNMYIEVC 195
>UniRef50_A1FG80 Cluster: Silent information regulator protein Sir2;
n=3; Pseudomonas|Rep: Silent information regulator
protein Sir2 - Pseudomonas putida W619
Length = 252
Score = 52.8 bits (121), Expect = 8e-06
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTLAK 517
I+ +GAG+S +GIP FR TGL +E PQ + FR+NP + L +
Sbjct: 17 IMVFTGAGVSAGSGIPTFRDELTGL------WERQDPQRLETAQAFRENPALVWGWYLWR 70
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
KP +H I L G + TQNID L AG ++++ HG+ C
Sbjct: 71 RQQVMQAKPNAAHQAIHRLSGSGRSVTVVTQNIDDLHERAG--NQEVLHLHGSLMRPKC 127
>UniRef50_Q7SB01 Cluster: Putative uncharacterized protein
NCU07624.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU07624.1 - Neurospora crassa
Length = 437
Score = 52.8 bits (121), Expect = 8e-06
Identities = 39/121 (32%), Positives = 58/121 (47%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
+ K + +GAG+STSAGIPDFR PE G++ + + RQ K +
Sbjct: 33 KSKHFVVFTGAGVSTSAGIPDFRGPE-GVWTLMAQ--------------GRQATKKSVDV 77
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
+ + PT +H + L E+G+L +QN D L R +GI + + E HG H
Sbjct: 78 LQAI------PTKTHMALVELQERGILKGLISQNCDGLHRRSGIRADMISELHGNTNIEH 131
Query: 692 C 694
C
Sbjct: 132 C 132
>UniRef50_A6TNA0 Cluster: Silent information regulator protein Sir2;
n=1; Alkaliphilus metalliredigens QYMF|Rep: Silent
information regulator protein Sir2 - Alkaliphilus
metalliredigens QYMF
Length = 249
Score = 52.4 bits (120), Expect = 1e-05
Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 4/135 (2%)
Frame = +2
Query: 302 DGIVRWIKS-DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
DG+++ + K + L+GAG+ T + IPDFRS E G + ++ P+ + I+
Sbjct: 12 DGVIKLASLIKKSKDTVILTGAGMDTESNIPDFRS-EKGWWRSI------DPRTVANIDT 64
Query: 479 FRQNPK---PFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPE 649
F +N F+ + L G +P HY + L +KG++ TQN+ L AG
Sbjct: 65 FYENYSLFHEFYDMRLRLLVG-IQPHKGHYILSDLEKKGMIRSIATQNVAGLHVMAG--S 121
Query: 650 EKLVEAHGTFYTSHC 694
+ + E HG C
Sbjct: 122 QNVYELHGNIRKIRC 136
>UniRef50_A1HLU5 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 261
Score = 52.4 bits (120), Expect = 1e-05
Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 2/120 (1%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKEL 523
I+ +GAG+ST +G+PDFRS + GL+ + +P+ + + + P F+ +
Sbjct: 19 IVVFTGAGMSTESGLPDFRSKQ-GLWKD-------RPETLATLAALKAKPDEFYFFYQWR 70
Query: 524 FP--GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+P H + L + G + + TQN+D L + AG + + E HGT T C+
Sbjct: 71 IARLWEVQPNPGHLALAELAQAGFVTKLVTQNVDGLHQRAG--SQGVAELHGTLRTVSCI 128
>UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:
CG3187-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 312
Score = 52.4 bits (120), Expect = 1e-05
Identities = 35/118 (29%), Positives = 56/118 (47%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKEL 523
++ L+GAGIST +GIPD+RS GLY ++ Q + + R+ +
Sbjct: 48 VLVLTGAGISTESGIPDYRSEGVGLYAR-SNHKPVQHMEFVKSSAVRKRYWARNFVGWPK 106
Query: 524 FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
F + +P +H+ + + + TQN+D L AG +VE HG+ Y CL
Sbjct: 107 FSAT-QPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVHGSGYVVKCL 161
>UniRef50_Q5CYK0 Cluster: Bacterial-like Sir2 family protein; n=2;
Cryptosporidium|Rep: Bacterial-like Sir2 family protein
- Cryptosporidium parvum Iowa II
Length = 299
Score = 52.4 bits (120), Expect = 1e-05
Identities = 41/129 (31%), Positives = 65/129 (50%), Gaps = 7/129 (5%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHN-LQKYELPQPQAIFEINFFRQNPKPFF 505
D KKI+ ++GAG+S +GIP FRS G + + EL +A I FR++P ++
Sbjct: 20 DSGKKILFITGAGLSLDSGIPLFRSESDGGDGSAIWNSEL---EAWATIGSFRKDPIKWY 76
Query: 506 TLAKELFP--GSF---KPTISHYFI-RLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEA 667
++ + F SF KP H + +L + ++ TQNID L + P E ++E
Sbjct: 77 SIFQNNFKFWSSFLTAKPNEGHRVLSKLCSDFPNRIKVITQNIDGLMQQTNCPRENIIEI 136
Query: 668 HGTFYTSHC 694
HG + C
Sbjct: 137 HGRIHYLRC 145
>UniRef50_Q7S223 Cluster: Putative uncharacterized protein
NCU05973.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU05973.1 - Neurospora crassa
Length = 334
Score = 52.4 bits (120), Expect = 1e-05
Identities = 35/127 (27%), Positives = 61/127 (48%), Gaps = 3/127 (2%)
Frame = +2
Query: 323 KSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKP- 499
K + +I+ + GAG+S ++G+P FR GL+ N + +L P+A F +P
Sbjct: 14 KLAKADRILAICGAGLSAASGLPTFRGVG-GLWRNYEATDLATPEA------FASDPGLV 66
Query: 500 --FFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHG 673
F+ + + + P H+ + L +K TQN+D L AG +++L HG
Sbjct: 67 WLFYAYRRHMALQAL-PNAGHHALAALAKKNPNFLCLTQNVDNLSSRAGHQQQQLHTLHG 125
Query: 674 TFYTSHC 694
+ +T C
Sbjct: 126 SLFTLQC 132
>UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2;
Caenorhabditis|Rep: Yeast sir related protein 2.4 -
Caenorhabditis elegans
Length = 299
Score = 51.6 bits (118), Expect = 2e-05
Identities = 38/119 (31%), Positives = 54/119 (45%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
K I L GAG+ST + +PDFR + G++ LQ F++
Sbjct: 56 KPIFVLIGAGVSTGSKLPDFRGKQ-GVW-TLQAEGKHAEGVDFQVA-------------- 99
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+P +SH I LH+ G + TQN+D L+R GIP E L+E HG + C
Sbjct: 100 -------RPGVSHKSILALHKAGYIKTIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVC 151
>UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2;
Saccharomycetales|Rep: Transcriptional regulatory
protein - Pichia stipitis (Yeast)
Length = 311
Score = 51.6 bits (118), Expect = 2e-05
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 7/127 (5%)
Frame = +2
Query: 335 CKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIF-EINFFRQNPKPFFTL 511
C+KI+ L GAG+S S+G+P FR + GL+ N +L P A + + Q F
Sbjct: 15 CRKIVALVGAGLSVSSGLPTFRGSQ-GLWKNFNMIDLATPDAFYIDPGLVWQ-----FYS 68
Query: 512 AKELFPGSFKPTISHYFIRLL------HEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHG 673
+ KP H + L + L TQN+D L +G +E L E HG
Sbjct: 69 WRRYNALQAKPNKGHLALSALSNLATRKDSNLEYITITQNVDGLSSRSGHAKENLYEIHG 128
Query: 674 TFYTSHC 694
+ + +C
Sbjct: 129 SLFNLNC 135
>UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14;
Mycobacterium|Rep: NAD-dependent deacetylase -
Mycobacterium leprae
Length = 237
Score = 51.6 bits (118), Expect = 2e-05
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 3/121 (2%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTLA 514
+++ LSGAGIS + +P FR + GL+ Y+L Q +++NP+ + L
Sbjct: 2 RVVVLSGAGISAESDVPTFRDDKNGLWARFDPYQLSSTQG------WQRNPERVWGWYLW 55
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTL-ERGAGIPEEKLVEAHGTFYTSH 691
+ + KP H I E+ + + TQN+D L ER P L HG+ + H
Sbjct: 56 RHYLVANVKPNDGHRAIAAWQEQ-IEVSVITQNVDDLHERAGSTPVHHL---HGSLFKFH 111
Query: 692 C 694
C
Sbjct: 112 C 112
>UniRef50_Q4RA56 Cluster: Chromosome undetermined SCAF24448, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF24448,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 85
Score = 51.2 bits (117), Expect = 2e-05
Identities = 21/35 (60%), Positives = 30/35 (85%)
Frame = +2
Query: 272 PEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGIST 376
P+KVLDE++L+G+ ++IKS +CK II + GAGIST
Sbjct: 51 PDKVLDELTLEGVAQYIKSGKCKNIICMVGAGIST 85
>UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus
thuringiensis serovar israelensis ATCC 35646|Rep: SIR2
family protein - Bacillus thuringiensis serovar
israelensis ATCC 35646
Length = 241
Score = 51.2 bits (117), Expect = 2e-05
Identities = 39/125 (31%), Positives = 62/125 (49%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
LD IK + I+ L+GAGIST +G+PD+RS GL+ + E+ A+ + F
Sbjct: 2 LDRAAELIK--KSNHIVVLTGAGISTDSGLPDYRS-NGGLWDGKKPEEISHFSAVGKPEF 58
Query: 479 FRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKL 658
K F ++ + KP +H + E+G + TQNID+ + AG + +
Sbjct: 59 V----KFFADRMNDI--SNCKPNKAHEILAKWEEQGKVKSVITQNIDSYHKDAG--SKNV 110
Query: 659 VEAHG 673
+E HG
Sbjct: 111 IEMHG 115
>UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP
ribosyltransferase; n=1; Blastopirellula marina DSM
3645|Rep: Sir2 family, possible ADP ribosyltransferase -
Blastopirellula marina DSM 3645
Length = 252
Score = 51.2 bits (117), Expect = 2e-05
Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 2/140 (1%)
Frame = +2
Query: 287 DEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQK--YELPQPQA 460
+++SL + RW+ + T GAGIST +GIPDFRSP G++ + ++ + A
Sbjct: 5 EDISL--VARWLAESESTVLFT--GAGISTESGIPDFRSP-GGVWTKYRTIYFDEFRQSA 59
Query: 461 IFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAG 640
++RQ + + + P H + G+ TQNID L + AG
Sbjct: 60 EARREYWRQKSEAHVEFS------AAAPNAGHQILAAWEAHGVARGLITQNIDGLHQIAG 113
Query: 641 IPEEKLVEAHGTFYTSHCLD 700
+++E HGT + CLD
Sbjct: 114 --SRQVLELHGTAREATCLD 131
>UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea 70-15
Length = 449
Score = 51.2 bits (117), Expect = 2e-05
Identities = 46/151 (30%), Positives = 70/151 (46%)
Frame = +2
Query: 242 SPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLY 421
+P P+ P E+ L ++ ++S R + + SGAGIS SAGIP F +
Sbjct: 73 TPDRSRPSSPQPA---EIDLVDAMQLLRSHR--QTVVFSGAGISVSAGIPTFADSQ---- 123
Query: 422 HNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRH 601
L++ + Q + + + F+ + + L ++ KPT H LL E+ ++ H
Sbjct: 124 --LKRSDF-QASTVDD-DAFQHDMTDLWHLTQQA-----KPTPFHV---LLEEQPSIVLH 171
Query: 602 YTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
TQNID LER E K V HG T C
Sbjct: 172 ITQNIDCLERSLPAAERKTVRLHGCLDTVRC 202
>UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 279
Score = 50.4 bits (115), Expect = 4e-05
Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT--LA 514
K++ L+GAGIS +GIP FR E Y + QPQ I + F+QNP+ + L
Sbjct: 20 KMVVLTGAGISAESGIPTFRGKEG--YWKIGSVNY-QPQEIGTMKMFKQNPQEVWKWYLF 76
Query: 515 KELFPGSFKPTISHYFIRLLHE--KGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
+ + +P HY + + + G TQN+D L AG + + HG
Sbjct: 77 RHTVCNNSQPNPGHYAVAEMEKILGGKRFTLVTQNVDGLHFRAGSTFKNTLLIHGDLTHV 136
Query: 689 HC 694
C
Sbjct: 137 RC 138
>UniRef50_Q62HT8 Cluster: Transcriptional regulator, Sir2 family;
n=39; Bacteria|Rep: Transcriptional regulator, Sir2
family - Burkholderia mallei (Pseudomonas mallei)
Length = 450
Score = 50.0 bits (114), Expect = 6e-05
Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 11/149 (7%)
Frame = +2
Query: 284 LDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPE------TGLYH-NLQKYE 442
+D +D VR + R ++ +GAGI +G+PDFR E GL H +E
Sbjct: 178 VDAERIDAAVRALS--RADALLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHE 235
Query: 443 LPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRH----YTQ 610
+ P+A FR+ P+ + ++ T+ H +L +RH +T
Sbjct: 236 IASPRA------FRERPRLAWGFYGHRL-AMYRATVPHEGFGILRRWIGAMRHGGFVFTS 288
Query: 611 NIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
N+D + AG E++VE HG+ + C+
Sbjct: 289 NVDGQFQKAGFDPERIVEVHGSIHAMQCM 317
>UniRef50_Q0LN22 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 243
Score = 49.6 bits (113), Expect = 7e-05
Identities = 32/121 (26%), Positives = 58/121 (47%), Gaps = 2/121 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL-- 511
+ ++ L+G+GIS +GIP +RS ++ P + F ++P F +
Sbjct: 16 QSLVVLTGSGISAPSGIPTYRSAAADA-----RWTAYDPDKVATFAGFERDPVGVFQVYQ 70
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
A + + +P HY + L + G + +TQNID+L + AG ++ E HG+ +
Sbjct: 71 AMKRQCEAAQPNAGHYALAQLEQLGTQFKLFTQNIDSLHQRAG--SSQVYEVHGSLARTI 128
Query: 692 C 694
C
Sbjct: 129 C 129
>UniRef50_A6G0H3 Cluster: Silent information regulator protein Sir2;
n=1; Plesiocystis pacifica SIR-1|Rep: Silent information
regulator protein Sir2 - Plesiocystis pacifica SIR-1
Length = 288
Score = 49.6 bits (113), Expect = 7e-05
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 3/114 (2%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT--LA 514
K++ +GAGIS +GIP FR PE ++Y +PQ + F + PK + L
Sbjct: 30 KVVVTTGAGISAESGIPTFRGPEGYWTVGAKEY---RPQELATREAFGKLPKEVWRWYLY 86
Query: 515 KELFPGSFKPTISH-YFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHG 673
++ + P +H +RL G TQN+D L AG E+ +E HG
Sbjct: 87 RKGVCNAAAPNPAHEALVRLEQALGERFCLVTQNVDGLHLRAGNSRERTIEVHG 140
>UniRef50_A1HU63 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 243
Score = 49.6 bits (113), Expect = 7e-05
Identities = 40/118 (33%), Positives = 56/118 (47%), Gaps = 2/118 (1%)
Frame = +2
Query: 353 LSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPG 532
L+GAGIST++GIPDFR G+ N +L Q F R+ P + L +
Sbjct: 23 LTGAGISTASGIPDFR----GI--NRINADLSQ----LTSTFMRRQPAKAYELLRPFIQT 72
Query: 533 --SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLD 700
+ P +H + L KG+L TQNID L AG + E HG Y +C++
Sbjct: 73 ILAASPNAAHIGLARLLAKGVLRGLMTQNIDGLHSRAG--AGVVWELHGNLYRGYCME 128
>UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.2;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein sir-2.2 - Caenorhabditis elegans
Length = 289
Score = 49.6 bits (113), Expect = 7e-05
Identities = 40/120 (33%), Positives = 54/120 (45%), Gaps = 2/120 (1%)
Frame = +2
Query: 341 KIITLSGAGISTSA--GIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLA 514
K++ +SGAGIST + GIPD+RS + GLY + + Q N RQ LA
Sbjct: 29 KLLVISGAGISTESVPGIPDYRSKDVGLYARIAHKPI-YFQDYMRSNRCRQRYWSRNFLA 87
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
F G P I+HY + TQN+D L AG + + E HG+ C
Sbjct: 88 WPRF-GQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAG--SKMVTELHGSALQVKC 144
>UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family
domain containing protein; n=2; Babesia bovis|Rep:
Transcriptional regulator, Sir2 family domain containing
protein - Babesia bovis
Length = 656
Score = 49.6 bits (113), Expect = 7e-05
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 5/127 (3%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPE---TGLYH-NLQKYELPQPQAIFEINFFRQNPKP 499
R K ++ SGAG+ST+AGIPDFR P T + H + + +
Sbjct: 46 RAKNVVLHSGAGMSTAAGIPDFRGPSGVWTVMSHKRVGNKKRKMTDGDCTVKDTSNTCVE 105
Query: 500 FFTLAKELFPGSFK-PTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGT 676
F T E S P+ +H L G + TQNID L +G+ + +E HG
Sbjct: 106 FGTTKLEPVEFSHALPSEAHLATLALLRAGYIRTVITQNIDGLHAISGMKHSECIELHGN 165
Query: 677 FYTSHCL 697
+ C+
Sbjct: 166 VFIERCI 172
>UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8;
Actinomycetales|Rep: NAD-dependent deacetylase 1 -
Streptomyces coelicolor
Length = 299
Score = 49.6 bits (113), Expect = 7e-05
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGL-YHNLQKYE--LPQPQAIFEINFFRQNPKPF 502
R ++ LSGAGIST +GIPD+R L H Y+ P+A ++ ++ +
Sbjct: 30 RAGGVLVLSGAGISTESGIPDYRGEGGSLSRHTPMTYQDFTAHPEA--RRRYWARSHLGW 87
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
T G +P H + GLL TQN+D L + AG E +VE HG+
Sbjct: 88 RTF------GRARPNAGHRSVAAFGRHGLLTGVITQNVDGLHQAAG--SEGVVELHGSLD 139
Query: 683 TSHCL 697
CL
Sbjct: 140 RVVCL 144
>UniRef50_P53688 Cluster: NAD-dependent histone deacetylase HST4;
n=5; Saccharomycetales|Rep: NAD-dependent histone
deacetylase HST4 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 370
Score = 49.6 bits (113), Expect = 7e-05
Identities = 37/102 (36%), Positives = 53/102 (51%), Gaps = 5/102 (4%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK---PFFT 508
K+++ +SGAGIS +AGIPDFRS E G++ + + +F+ N + F
Sbjct: 93 KRMVVVSGAGISVAAGIPDFRSSE-GIFSTVNG---GSGKDLFDYNRVYGDESMSLKFNQ 148
Query: 509 LAKELF--PGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
L LF + +PT H + G LLR YTQNID L+
Sbjct: 149 LMVSLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQNIDGLD 190
>UniRef50_A5USR3 Cluster: Silent information regulator protein Sir2;
n=3; Chloroflexi (class)|Rep: Silent information
regulator protein Sir2 - Roseiflexus sp. RS-1
Length = 259
Score = 49.2 bits (112), Expect = 1e-04
Identities = 33/123 (26%), Positives = 57/123 (46%), Gaps = 2/123 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT--L 511
++++ L+G G++ +GIP FR TG + EL PQA F +NP+ +
Sbjct: 17 RRVVALTGGGVAAESGIPSFREAHTGHWAQYDVSELATPQA------FVRNPRLVWEWYA 70
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
+ + +P ++HY + L + TQ+ID L AG L+E +G+
Sbjct: 71 YRRMLAERAQPGVTHYALVDLEQHYPAFTLITQSIDGLHWRAG--SRDLIELNGSLRRCR 128
Query: 692 CLD 700
C +
Sbjct: 129 CFE 131
>UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Pezizomycotina|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 381
Score = 49.2 bits (112), Expect = 1e-04
Identities = 38/123 (30%), Positives = 60/123 (48%), Gaps = 2/123 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R + + L+GAGIS ++G+ D+R E G Y + Y +P E ++ K ++
Sbjct: 53 RHSQAVLLTGAGISVASGLSDYRG-EKGTYVTNKFY---RPIYFHEFLSRHESRKRYWAR 108
Query: 512 AKELFPGSFK--PTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
+ +PG K P +H+ IR L KG + TQN+D+ A PE +E HG +
Sbjct: 109 SFVGWPGLLKAEPNSTHWAIRDLAAKGFVSSVVTQNVDSFHSIAH-PELPTIELHGHLKS 167
Query: 686 SHC 694
C
Sbjct: 168 VVC 170
>UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1040
Score = 49.2 bits (112), Expect = 1e-04
Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 3/124 (2%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK---PF 502
+ + I+ + GAG+S S+G+ FR P GL+ N + L P F +P F
Sbjct: 32 KSRNIVAIIGAGLSASSGLATFRGPG-GLWQNQDVFVLASPAG------FVNDPGLVWQF 84
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFY 682
++ +E + +P +H + L K TQN+D L AG P ++L+E HG +
Sbjct: 85 YSYRREEALKA-QPNKAHRALAELARKVPGFTMLTQNVDNLSPRAGHPADQLLELHGNLF 143
Query: 683 TSHC 694
C
Sbjct: 144 DLKC 147
>UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins; n=1; Aspergillus
niger|Rep: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins - Aspergillus niger
Length = 357
Score = 49.2 bits (112), Expect = 1e-04
Identities = 37/132 (28%), Positives = 65/132 (49%), Gaps = 2/132 (1%)
Frame = +2
Query: 311 VRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQN 490
+R + R + + L+GAGIS ++G+ D+R E G Y + Y +P E +
Sbjct: 46 LRGVDVGRHSQTVLLTGAGISVASGLSDYRG-ENGTYITNKTY---RPIYYHEFVARHEF 101
Query: 491 PKPFFTLAKELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVE 664
K ++ + +PG KP +H+ I+ + KG + TQN+D+ A PE +E
Sbjct: 102 RKRYWARSFIGWPGLLKAKPNSTHWAIKDIGTKGYISSVVTQNVDSFHSVAH-PELPTLE 160
Query: 665 AHGTFYTSHCLD 700
HG ++ C++
Sbjct: 161 LHGYLRSAVCIN 172
>UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
(strain EbN1))
Length = 260
Score = 48.4 bits (110), Expect = 2e-04
Identities = 37/136 (27%), Positives = 59/136 (43%), Gaps = 2/136 (1%)
Frame = +2
Query: 299 LDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINF 478
LD + R I +I+ ++GAGIS +G+P +R GLYH + +
Sbjct: 7 LDAVARLIAG--APRILFITGAGISADSGLPTYRG-IGGLYHERLTDDGLTIEEALSGEM 63
Query: 479 FRQNPKPFFTLAKELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEE 652
+P+ + E+ P I+H I L + + TQN+D L R AG
Sbjct: 64 MEAHPEVAWKYIAEIEANCRGAAPNIAHRIIAALEHERPGVWVLTQNVDGLHRAAG--SR 121
Query: 653 KLVEAHGTFYTSHCLD 700
L+E HG+ + C +
Sbjct: 122 NLIEIHGSVHRLRCTE 137
>UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1;
Mycobacterium ulcerans Agy99|Rep: Sir2-like regulatory
protein - Mycobacterium ulcerans (strain Agy99)
Length = 283
Score = 48.4 bits (110), Expect = 2e-04
Identities = 33/119 (27%), Positives = 55/119 (46%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
+I L+GAGIST +GIPD+R P++ + + + +F ++ +N + +
Sbjct: 14 RIAVLTGAGISTDSGIPDYRGPDSPPSNPMTIRQFTS-DPVFRQRYWARNHVGWRHM--- 69
Query: 521 LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
P H + L G++ TQN+D L AG + +V HGT+ CL
Sbjct: 70 ---DDTAPNAGHRALAALERAGVVTGVITQNVDLLHTKAG--SKNVVNLHGTYAQVTCL 123
>UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 346
Score = 48.4 bits (110), Expect = 2e-04
Identities = 39/126 (30%), Positives = 63/126 (50%), Gaps = 6/126 (4%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNL-----QKYELPQPQAIFEINFF-RQNPKP 499
KKI+ ++GAG+S ++GI +R+ +T ++ N + + Q A F +F+ R + K
Sbjct: 45 KKILFITGAGLSINSGISAYRNTKTSVWSNFITEWGTRKKFEQDPAQFWNHFWLRTHEKQ 104
Query: 500 FFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTF 679
+ + P S IS+ F+ L + TQN+D L A +P EKLVE HG
Sbjct: 105 EYL---DALPNSGHLAISN-FVEYLGSNVI-----TQNVDALHLKAKVPIEKLVEVHGRI 155
Query: 680 YTSHCL 697
C+
Sbjct: 156 SLYKCI 161
>UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Ralstonia
solanacearum (Pseudomonas solanacearum)
Length = 246
Score = 48.4 bits (110), Expect = 2e-04
Identities = 38/145 (26%), Positives = 67/145 (46%), Gaps = 2/145 (1%)
Frame = +2
Query: 272 PEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQ 451
P V D + WI++ ++++ L+GAG+S +G+P FR TGL+ +L
Sbjct: 2 PTAVSDAAAPAQARAWIEA--AERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLAT 59
Query: 452 PQAIFEINFFRQNPKPFFTLAKE--LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTL 625
A +R++P+ + +E +P +H I L + + TQN+D L
Sbjct: 60 EAA------YREHPRMVWDWYQERRARVSQVQPNPAHLAIAALATRKTVAL-VTQNVDGL 112
Query: 626 ERGAGIPEEKLVEAHGTFYTSHCLD 700
+ AG ++E HG + + LD
Sbjct: 113 HQRAG--SVGVIELHGNLFANKWLD 135
>UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305-PA
- Drosophila melanogaster (Fruit fly)
Length = 771
Score = 48.0 bits (109), Expect = 2e-04
Identities = 39/121 (32%), Positives = 55/121 (45%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
+ K ++ +GAGIST+A IPD+R + G++ LQK Q I E + NP
Sbjct: 122 QAKHLVCYTGAGISTAALIPDYRGSQ-GIWTLLQK-----GQDIGEHDLSSANP------ 169
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
T +H + LH + LL +QN D L +G+P L E HG Y
Sbjct: 170 -----------TYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEV 218
Query: 692 C 694
C
Sbjct: 219 C 219
>UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Rep:
ABL004Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 319
Score = 48.0 bits (109), Expect = 2e-04
Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 7/128 (5%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTL 511
+KI+ + GAG+S S+G+ F++ G + EL P+A F++NP+ F
Sbjct: 19 RKILCIVGAGLSASSGLTTFQAAH-GEWRGHSALELATPEA------FQENPELVWVFYS 71
Query: 512 AKELFPGSFKPTISHYFI-----RLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGT 676
A+ +P H+ + R+ ++ + TQN+D L AG PE VE HG+
Sbjct: 72 ARRYTAMKARPNNGHFALAELCRRVAADERREILLVTQNVDGLHWRAGQPEASTVELHGS 131
Query: 677 FYTSHCLD 700
+ C +
Sbjct: 132 VFDYRCTE 139
>UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12;
Magnoliophyta|Rep: SIR2-family protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 451
Score = 47.6 bits (108), Expect = 3e-04
Identities = 37/124 (29%), Positives = 58/124 (46%)
Frame = +2
Query: 329 DRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT 508
++ ++ L+GAG+ST GIPD+RSP G Y + ++ Q + R+
Sbjct: 166 EQSSRLTILTGAGVSTECGIPDYRSP-NGAYSS--GFKPITHQEFTRSSRARRRYWARSY 222
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
F + +P +H + L + G + TQN+D L AG +E HGT YT
Sbjct: 223 AGWRRFTAA-QPGPAHTALASLEKAGRINFMITQNVDRLHHRAG---SDPLELHGTVYTV 278
Query: 689 HCLD 700
CL+
Sbjct: 279 MCLE 282
>UniRef50_A7DQD6 Cluster: Silent information regulator protein Sir2;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Silent information regulator protein Sir2 - Candidatus
Nitrosopumilus maritimus SCM1
Length = 242
Score = 47.6 bits (108), Expect = 3e-04
Identities = 42/121 (34%), Positives = 57/121 (47%), Gaps = 2/121 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
KKI+ ++GAGIS +GIP FR + GL+ N +L I+ F +PK +
Sbjct: 15 KKIVFVTGAGISQESGIPTFRGKD-GLWRNYDAMKLA------TIDAFYDDPKLVWEWYN 67
Query: 518 ELFPGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
E F P H I L EK + TQNID L + AG K++E HG+
Sbjct: 68 ERRHNIFSANPNQGHKAIAEL-EKFADVVSLTQNIDGLHQKAG--STKVLELHGSIVKIK 124
Query: 692 C 694
C
Sbjct: 125 C 125
>UniRef50_A5WD15 Cluster: Silent information regulator protein Sir2;
n=2; Psychrobacter|Rep: Silent information regulator
protein Sir2 - Psychrobacter sp. PRwf-1
Length = 249
Score = 47.2 bits (107), Expect = 4e-04
Identities = 37/129 (28%), Positives = 61/129 (47%), Gaps = 8/129 (6%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
+ +I L+GAGIS +GIP FR +TGL+ N + +L IN F+++P+ ++
Sbjct: 14 KANRIFLLTGAGISAESGIPTFRDKQTGLWENYRAEDLA------NINAFKKDPQTVWSW 67
Query: 512 A--KELFPGSFKPTISHYFIRLLHE------KGLLLRHYTQNIDTLERGAGIPEEKLVEA 667
+ +P +HY + L + K L TQN+D L AG + +
Sbjct: 68 YQWRRGLVQDKQPNPAHYALANLQQWATDNHKDCSL--ITQNVDDLHEQAG---SQAIHL 122
Query: 668 HGTFYTSHC 694
HG + + C
Sbjct: 123 HGHLWKNKC 131
>UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins;
n=10; Pezizomycotina|Rep: Sirtuin 4 and related class II
sirtuins - Aspergillus oryzae
Length = 407
Score = 47.2 bits (107), Expect = 4e-04
Identities = 40/133 (30%), Positives = 63/133 (47%), Gaps = 4/133 (3%)
Frame = +2
Query: 311 VRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQN 490
+R + R + + L+GAGIS ++G+ D+R E G Y + Y +P E +
Sbjct: 73 LRGVDVGRYSQTVLLTGAGISVASGLSDYRG-ENGTYVTNKTY---RPIYFHEFLKRHEF 128
Query: 491 PKPFFTLAKELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKL-- 658
K ++ + +PG KP +H+ IR L KG L TQN+D+ I KL
Sbjct: 129 RKRYWARSFVGWPGLVKAKPNSTHWAIRDLGAKGYLSSVVTQNVDSFH---PIAHSKLST 185
Query: 659 VEAHGTFYTSHCL 697
+E HG + C+
Sbjct: 186 IELHGYLRSVVCI 198
>UniRef50_A6RSV6 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 1195
Score = 47.2 bits (107), Expect = 4e-04
Identities = 24/57 (42%), Positives = 38/57 (66%), Gaps = 1/57 (1%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KYELPQPQAIFEINFFRQNPKP 499
+ +K++ ++GAGIST+ GIPDFRS E GLY +Q +Y+ +EIN + + +P
Sbjct: 23 KSRKVVVVTGAGISTNVGIPDFRS-EHGLYSMIQAQYDAALENPPWEINDYDIDDRP 78
Score = 41.1 bits (92), Expect = 0.026
Identities = 18/33 (54%), Positives = 23/33 (69%)
Frame = +2
Query: 545 TISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
T +H FIR L + G L+R+YTQNID LE G+
Sbjct: 618 TTTHQFIRSLRDNGRLVRNYTQNIDCLEEREGL 650
>UniRef50_A6WG46 Cluster: Silent information regulator protein Sir2;
n=4; Actinomycetales|Rep: Silent information regulator
protein Sir2 - Kineococcus radiotolerans SRS30216
Length = 279
Score = 46.8 bits (106), Expect = 5e-04
Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 1/120 (0%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLY-HNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
+++ L GAG+ST +GIPD+R P L H Y+ A ++ ++ +
Sbjct: 15 RVVVLEGAGMSTGSGIPDYRGPGGSLQRHTPMTYQEFTGSAEARRRYWGRS-----HVGW 69
Query: 518 ELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
E F + +P +H + L G++ TQN+D L+ AG E +VE HG CL
Sbjct: 70 EHFRRA-RPNDAHRAVAALEGAGVVTGVITQNVDGLDLAAGTRE--VVELHGNLDRVVCL 126
>UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13;
Campylobacter|Rep: NAD-dependent deacetylase -
Campylobacter jejuni
Length = 233
Score = 46.8 bits (106), Expect = 5e-04
Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTL 511
K I+ LSGAG+S +G+ FR + GL+ ++Y++ + + FR+NPK F
Sbjct: 2 KNIMILSGAGLSAPSGLKTFRDND-GLW---EEYDVME---VCSATGFRKNPKKVLDFYD 54
Query: 512 AKELFPGSFKPTISHYFIRLLHEK-GLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
A+ + KP +H I L EK G L TQN+D L AG + +V HG
Sbjct: 55 ARRAQLQNVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKD--VVHLHGFLPEL 112
Query: 689 HCL 697
CL
Sbjct: 113 RCL 115
>UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9;
Corynebacterineae|Rep: NAD-dependent deacetylase 2 -
Corynebacterium efficiens
Length = 254
Score = 46.8 bits (106), Expect = 5e-04
Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 4/123 (3%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
+ I +GAG+S +G+ +R PETG++ + PQA+ I+ + ++P+P + +
Sbjct: 17 RNIEVFTGAGMSADSGLETYRDPETGVWSKV------DPQAMASIDAWARDPEPMWAWYR 70
Query: 518 ELFPGSFK--PTISHYFIRLLHEKGLL--LRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
+ K P H I L+ + TQNID L AG E + HG+ +
Sbjct: 71 WRAGQAMKARPNAGHETIAYWEGSHLVDAVHVTTQNIDNLHERAGSTE--VTHLHGSLFE 128
Query: 686 SHC 694
C
Sbjct: 129 FRC 131
>UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Epsilonproteobacteria|Rep: Transcriptional
regulator, Sir2 family protein - Caminibacter
mediatlanticus TB-2
Length = 264
Score = 46.4 bits (105), Expect = 7e-04
Identities = 39/125 (31%), Positives = 60/125 (48%), Gaps = 6/125 (4%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPET--GLYHNLQKYELPQPQAIFEINFFRQNPK---PF 502
K ++ +GAG+ +G+PDFR E Y +K L QA+ +F NPK F
Sbjct: 15 KYLLITAGAGMGVDSGLPDFRGNEGFWRAYPIAKKLGL-NFQALANPTWFDINPKLAWAF 73
Query: 503 FTLAKELFPGSFKPTISHYFIRLL-HEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTF 679
+ L+ + P Y ++ L HEK + +T N+D + AG E K+VE HG+
Sbjct: 74 YGHRLNLYRNT-TPHKGFYILKKLPHEKFV----FTSNVDGQFQKAGFSEMKIVEIHGSI 128
Query: 680 YTSHC 694
+ C
Sbjct: 129 HYLQC 133
>UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=5;
Plasmodium|Rep: NAD-dependent deacetylase, putative -
Plasmodium vivax
Length = 306
Score = 46.4 bits (105), Expect = 7e-04
Identities = 33/140 (23%), Positives = 65/140 (46%), Gaps = 1/140 (0%)
Frame = +2
Query: 278 KVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQ 457
+V ++L+ + I+ C ++ L+G+G S + IP FR + ++ KY+ P+
Sbjct: 11 RVTKSITLEDLACMIRG--CTYVVALTGSGTSAESNIPSFRGANSSIW---SKYD---PK 62
Query: 458 AIFEINFFRQNPKPFFTLAKELFPG-SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERG 634
I F ++P+ + + +++ + H + L G L TQNID L
Sbjct: 63 IYGTIWGFWKSPEKIWEVIRDISSDYEIELNPGHTALSKLESLGYLKTVITQNIDGLHEE 122
Query: 635 AGIPEEKLVEAHGTFYTSHC 694
+G K++ HG+ + + C
Sbjct: 123 SG--NSKVIPLHGSVFEARC 140
>UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5
(silent mating type information regulation 2 homolog) 5;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
sirtuin 5 (silent mating type information regulation 2
homolog) 5 - Tribolium castaneum
Length = 254
Score = 46.0 bits (104), Expect = 9e-04
Identities = 37/122 (30%), Positives = 61/122 (50%), Gaps = 7/122 (5%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPK---PF 502
+ + I+ L+GAG+S +GIP FR GL+ + +L P A FR NP F
Sbjct: 18 QARSIVALTGAGVSAESGIPVFRG-AGGLWRTHRATDLATPTA------FRANPALVWEF 70
Query: 503 FTLAKELFPGSFKPTISH----YFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAH 670
+ +++ S +P +H + ++ E+G TQN+D L + AG E ++E H
Sbjct: 71 YHYRRDVAFNS-QPNNAHKALAKYEKICKEQGRQFHVITQNVDGLHKRAG--SENVLELH 127
Query: 671 GT 676
G+
Sbjct: 128 GS 129
>UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family
protein; n=3; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 386
Score = 46.0 bits (104), Expect = 9e-04
Identities = 37/117 (31%), Positives = 53/117 (45%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELF 526
+ +GAGISTSAGI DFRS + L ++E + +P ++
Sbjct: 39 VCFTGAGISTSAGIADFRSGVNTV--------LKTGPGLWEKMAQKVGNQP---KKHKVI 87
Query: 527 PGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
PT SH + L+++G+L +QNID L R +G L E HG CL
Sbjct: 88 MSRAVPTKSHMALVKLNQEGILKYLISQNIDGLHRRSGFNPNSLSELHGNTNLEKCL 144
>UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2;
Halobacteriaceae|Rep: NAD-dependent deacetylase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 260
Score = 46.0 bits (104), Expect = 9e-04
Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 5/144 (3%)
Frame = +2
Query: 284 LDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAI 463
+D +LD + +++ + + L+GAG+ST++GIP FR + G+ +E P A
Sbjct: 11 IDGETLDAVAEALRT--AETAVALTGAGVSTASGIPSFRG-DDGI------WERHDP-AD 60
Query: 464 FEINFFRQNPKPFFT---LAKELFPGSF--KPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
F +P F+ +E G +P +H + L G L TQNID L
Sbjct: 61 FHRRRLDADPAGFWADRLSLREAIYGDIDPEPNAAHEALAALEADGHLDAVLTQNIDGLH 120
Query: 629 RGAGIPEEKLVEAHGTFYTSHCLD 700
AG +++VE HGT C D
Sbjct: 121 DAAG--TDRVVELHGTHRRVVCDD 142
>UniRef50_A0JXS0 Cluster: Silent information regulator protein Sir2
precursor; n=11; Actinomycetales|Rep: Silent information
regulator protein Sir2 precursor - Arthrobacter sp.
(strain FB24)
Length = 306
Score = 45.6 bits (103), Expect = 0.001
Identities = 44/157 (28%), Positives = 67/157 (42%), Gaps = 1/157 (0%)
Frame = +2
Query: 230 LGLFSPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRC-KKIITLSGAGISTSAGIPDFRSP 406
LG+ L P DE+ G++R I+ + L+GAG+ST +GIPD+R P
Sbjct: 8 LGMTGFASLPPVGAAAPAPDEL---GVLRGIRDAIAGTRFALLTGAGLSTDSGIPDYRGP 64
Query: 407 ETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKG 586
+ + Y+ A ++ +N + L + P H L ++G
Sbjct: 65 DAAPRAPM-TYQEFIGHAGNRQRYWARNHIGWSHLRRA------DPNDGHAAAARLEQRG 117
Query: 587 LLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
LL TQN+D L AG +V+ HG F CL
Sbjct: 118 LLTGLITQNVDRLHEDAG--SVNVVDLHGRFDRVACL 152
>UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_29_33086_34261 - Giardia lamblia
ATCC 50803
Length = 391
Score = 45.6 bits (103), Expect = 0.001
Identities = 40/141 (28%), Positives = 66/141 (46%), Gaps = 6/141 (4%)
Frame = +2
Query: 296 SLDGIVRWIKSDRC-KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEI 472
SL+ I++ ++ R + +I ++GAG+S ++GI +R ++ N A E
Sbjct: 44 SLNAILQLARTLRAGRAVIFVTGAGLSYASGITPYRYSNKAIWSNFV-------MASGER 96
Query: 473 NFFRQNPKPF---FTLAKELFPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGA 637
F+++P + F L P + KP H I + K + TQNIDTL +
Sbjct: 97 RTFKEDPDQYWNSFWLRTHEIPSFINAKPNQGHIAIAKIMRKADVFV-ITQNIDTLHTKS 155
Query: 638 GIPEEKLVEAHGTFYTSHCLD 700
G E +LVE HG C++
Sbjct: 156 GALENRLVEIHGRLGLYKCVN 176
>UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;
Coelomata|Rep: Chromatin regulatory protein sir2 - Aedes
aegypti (Yellowfever mosquito)
Length = 720
Score = 45.6 bits (103), Expect = 0.001
Identities = 39/121 (32%), Positives = 56/121 (46%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R ++ +GAGISTSA IPD+R + G++ L Q + I E + +L
Sbjct: 79 RSNHLMVYTGAGISTSAKIPDYRGSQ-GIWTLLA-----QGKDIGEYDL---------SL 123
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
A PT +H + LH +G+L +QN D L +G+P L E HG Y
Sbjct: 124 AD--------PTYTHMALSELHRRGILKHVVSQNCDGLHLRSGLPRFCLSEVHGNMYVEV 175
Query: 692 C 694
C
Sbjct: 176 C 176
>UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4;
Deinococci|Rep: NAD-dependent deacetylase - Deinococcus
radiodurans
Length = 246
Score = 45.6 bits (103), Expect = 0.001
Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 9/121 (7%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAK 517
+++ L+GAGIS +GIP FR +TG + + +L P A +R++P L
Sbjct: 14 RRVAVLTGAGISAESGIPTFRDAQTGHWARFRPEDLASPDA------YRRDP----DLVW 63
Query: 518 ELFPGSFK------PTISHYFI-RLLHEKGLLLRHYTQNIDTL--ERGAGIPEEKLVEAH 670
E + G ++ P H + L KG TQN+D L G+G +LVE H
Sbjct: 64 EWYAGRYRDVLAAQPNRGHELLAELERRKGPGFFLATQNVDGLHARAGSGSAGGELVELH 123
Query: 671 G 673
G
Sbjct: 124 G 124
>UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5;
Pseudomonas|Rep: NAD-dependent deacetylase 3 -
Pseudomonas syringae pv. tomato
Length = 281
Score = 45.6 bits (103), Expect = 0.001
Identities = 38/142 (26%), Positives = 67/142 (47%), Gaps = 2/142 (1%)
Frame = +2
Query: 281 VLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQA 460
+LD +LD + ++ K + ++GAGIST++GIPD+R + G+ QP
Sbjct: 1 MLDSPTLDLLDSLRRTMAEKSFLVVTGAGISTASGIPDYRDKD-GVRRG------AQPMM 53
Query: 461 IFEINFFRQNPKPFFTLAKELFP--GSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERG 634
E + ++ A +P + + +H + L + L+ TQN+D L
Sbjct: 54 YQEFVGNPAARQRYWARAMLGWPRISASQANAAHRALAALQAENLIKGLITQNVDALHTQ 113
Query: 635 AGIPEEKLVEAHGTFYTSHCLD 700
AG + ++E HG+ + CLD
Sbjct: 114 AG--SQDVIELHGSLHRVLCLD 133
>UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 281
Score = 45.2 bits (102), Expect = 0.002
Identities = 38/131 (29%), Positives = 68/131 (51%), Gaps = 5/131 (3%)
Frame = +2
Query: 296 SLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPE-TGLYHNLQKYELPQPQAIFEI 472
+++ ++ IK+++ K + ++GAGIS +P FRS + +GL+ L+ +L +
Sbjct: 27 NIETVINLIKNNKGKTCV-ITGAGISAPQ-LPTFRSRDNSGLWDVLKAPDLSK------- 77
Query: 473 NFFRQNPKPFFTLAKEL----FPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAG 640
+ F QNP P + LA + + K T++H + + G + TQN D+L
Sbjct: 78 SVFYQNPLPSWRLAANIRNLQLNKTLKHTLAHNVLHQMVIDGYVSDLLTQNCDSLHSYDD 137
Query: 641 IPEEKLVEAHG 673
+EK+VE HG
Sbjct: 138 EYDEKVVELHG 148
>UniRef50_Q2GZ88 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 895
Score = 45.2 bits (102), Expect = 0.002
Identities = 22/49 (44%), Positives = 35/49 (71%), Gaps = 1/49 (2%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ-KYELPQPQAIFEIN 475
+ +K++ ++GAGIST++GIPDFRS E GLY +Q +++ Q Q + N
Sbjct: 23 KSRKVVVITGAGISTNSGIPDFRS-ENGLYSLIQAQFDEAQQQQATDSN 70
Score = 38.7 bits (86), Expect = 0.14
Identities = 17/35 (48%), Positives = 23/35 (65%)
Frame = +2
Query: 539 KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
+PT SH F+ +L + L+R YTQNID LE G+
Sbjct: 265 EPTSSHRFVSVLRDSRKLVRCYTQNIDQLEERVGL 299
>UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Bradyrhizobium japonicum
Length = 273
Score = 45.2 bits (102), Expect = 0.002
Identities = 32/122 (26%), Positives = 56/122 (45%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R +++ L+GAG ST++GIPD+R + N ++ + QA R+ +
Sbjct: 17 RHQRLFVLTGAGCSTNSGIPDYRDS----HGNWKRTQPVNFQAFMSEEHTRRRYWARSLI 72
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
F G +P +H+ + L G TQN+D L + AG ++++ HG
Sbjct: 73 GWRRF-GQARPNDAHHALARLEANGRCGMLLTQNVDRLHQSAG--HRQVIDLHGRLDLVR 129
Query: 692 CL 697
C+
Sbjct: 130 CM 131
>UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG11305-PA - Tribolium castaneum
Length = 627
Score = 44.8 bits (101), Expect = 0.002
Identities = 44/147 (29%), Positives = 68/147 (46%)
Frame = +2
Query: 254 LEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ 433
LE E P +VL E L + + I + + ++ +GAGIST+A IPD+R P G++ LQ
Sbjct: 95 LEEFEEPPEVLKEKCLI-LAQAIA--QAQHLVVYTGAGISTAAKIPDYRGP-NGIWTRLQ 150
Query: 434 KYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQN 613
+ + +I A +L +PT +H + L+ +L +QN
Sbjct: 151 QGK--------DIG------------AHDL--SMAEPTYTHMALSELYRNKILKYVVSQN 188
Query: 614 IDTLERGAGIPEEKLVEAHGTFYTSHC 694
D L +G+P L E HG Y C
Sbjct: 189 CDGLHLRSGLPRTALSELHGNMYIEVC 215
>UniRef50_Q7S386 Cluster: Putative uncharacterized protein
NCU04859.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU04859.1 - Neurospora crassa
Length = 1327
Score = 44.8 bits (101), Expect = 0.002
Identities = 19/34 (55%), Positives = 28/34 (82%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQ 433
+ +K++ ++GAGIST++GIPDFRS E GLY +Q
Sbjct: 23 KARKVVVITGAGISTNSGIPDFRS-ENGLYSLIQ 55
Score = 40.7 bits (91), Expect = 0.034
Identities = 17/35 (48%), Positives = 24/35 (68%)
Frame = +2
Query: 539 KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
+PT SH+F+ +L + L+R YTQNID LE G+
Sbjct: 254 EPTTSHHFVSVLRDSRKLVRCYTQNIDQLEERVGL 288
>UniRef50_A4UCE7 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1122
Score = 44.8 bits (101), Expect = 0.002
Identities = 19/35 (54%), Positives = 26/35 (74%)
Frame = +2
Query: 539 KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
KPT +H+FI L +KG L+R YTQNID +E+ G+
Sbjct: 266 KPTSTHHFISHLRDKGKLVRCYTQNIDEIEKRVGL 300
>UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein;
n=2; Acinetobacter|Rep: Putative cobalamin biosynthetic
protein - Acinetobacter sp. (strain ADP1)
Length = 233
Score = 44.0 bits (99), Expect = 0.004
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNP---KPFFT 508
KK++ SGAG+S +GI FR + GL+ N + E+ P+A ++QNP + F+
Sbjct: 2 KKLVVFSGAGMSAESGIHTFRDHD-GLWENYRIEEVATPEA------WQQNPSLVQHFYN 54
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAG 640
++ + +P ++H I L E ++ TQNID L AG
Sbjct: 55 ERRKNILAA-QPNLAHQIIAQL-ESCYQVQVITQNIDDLHERAG 96
>UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus
xanthus DK 1622|Rep: Sir2 family protein - Myxococcus
xanthus (strain DK 1622)
Length = 287
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPET--GLYHNLQKYE-LPQPQAIFEINFFRQNPKPFFT 508
+ + L+GAG ST +GIPD+R P T + +Q E L +P+ ++ ++
Sbjct: 27 RSTVVLTGAGCSTESGIPDYRGPGTRARARNPIQHREFLTRPEV--RARYWARS-----L 79
Query: 509 LAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTS 688
+ F S +P +H + L + G + TQN+D L AG +++E HG
Sbjct: 80 MGWPRF-SSARPNAAHAALAELEQAGHVRGLITQNVDGLHHAAG--SSRVIELHGALAQV 136
Query: 689 HCL 697
CL
Sbjct: 137 RCL 139
>UniRef50_A7H7B6 Cluster: Silent information regulator protein Sir2;
n=2; Anaeromyxobacter|Rep: Silent information regulator
protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 270
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/123 (30%), Positives = 55/123 (44%), Gaps = 3/123 (2%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
+++ L+GAG+S +GIP FR E G + + +PQ A E+ F + P+ +
Sbjct: 18 RVVALTGAGVSAESGIPTFRGRE-GFWVVGSRNYMPQEMATHEM--FARAPEEVWRWYLH 74
Query: 521 LFP--GSFKPTISH-YFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
F +P H + L G TQNID L R AG E+++ HG
Sbjct: 75 RFGVCRDARPNAGHAALVALERALGERFTLVTQNIDGLHRRAG--SERVLCIHGDAAYVR 132
Query: 692 CLD 700
C D
Sbjct: 133 CAD 135
>UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin
(silent mating type information regulation 2 homolog) 6
(S. cerevisiae); n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Sirtuin (silent mating type
information regulation 2 homolog) 6 (S. cerevisiae) -
Strongylocentrotus purpuratus
Length = 521
Score = 43.6 bits (98), Expect = 0.005
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Frame = +2
Query: 482 RQNPKPFFTLAKE-------LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAG 640
R+ PK +TL K+ + + KPT +H + L +G L +QNID L +G
Sbjct: 10 RRGPKGVWTLEKQGKKPEANVTFDTAKPTATHMALVELERRGKLQYLISQNIDGLHLRSG 69
Query: 641 IPEEKLVEAHGTFYTSHC 694
P+++L E HG + C
Sbjct: 70 FPKDRLAELHGNMFVEQC 87
>UniRef50_UPI000023F1DF Cluster: hypothetical protein FG02466.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG02466.1 - Gibberella zeae PH-1
Length = 1569
Score = 43.6 bits (98), Expect = 0.005
Identities = 19/30 (63%), Positives = 26/30 (86%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLY 421
+ +K+I ++GAGIST++GIPDFRS E GLY
Sbjct: 640 KARKVIVVTGAGISTNSGIPDFRS-ENGLY 668
Score = 40.7 bits (91), Expect = 0.034
Identities = 18/35 (51%), Positives = 24/35 (68%)
Frame = +2
Query: 539 KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGI 643
+PT SH FI L ++G L+R YTQNID +E G+
Sbjct: 912 EPTSSHRFISHLRDRGKLVRCYTQNIDQIEEKVGL 946
>UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium longum|Rep: Sir2-type regulatory protein
- Bifidobacterium longum
Length = 216
Score = 43.6 bits (98), Expect = 0.005
Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Frame = +2
Query: 458 AIFEINFFRQNPKP---FFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLE 628
++++I+ F +N + + KE + +P +H + L + G+L TQN D L
Sbjct: 2 SVYDIDLFLRNKEDREYSWRWQKESPVWNAQPGTAHKALVKLEQAGMLTLLATQNFDALH 61
Query: 629 RGAGIPEEKLVEAHGTFYTSHCL 697
AG + +V HGT TSHC+
Sbjct: 62 EKAGNSDNVIVNLHGTIGTSHCM 84
>UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis
pacifica SIR-1|Rep: Sir2 family protein - Plesiocystis
pacifica SIR-1
Length = 297
Score = 43.2 bits (97), Expect = 0.006
Identities = 32/121 (26%), Positives = 53/121 (43%), Gaps = 1/121 (0%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPET-GLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLA 514
++++ L+GAG ST +GIPD+R T N ++ ++ + + L+
Sbjct: 34 RRVVALTGAGCSTESGIPDYRGEGTRARARNPIRFSAYVEDPEARARYWSRAVVGWPKLS 93
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHC 694
+ +P +H + L G+L TQN+D L AG +VE HG C
Sbjct: 94 RA------RPNAAHRVLAQLEAAGVLSGLITQNVDRLHHQAG--SRAVVELHGALAEVRC 145
Query: 695 L 697
L
Sbjct: 146 L 146
>UniRef50_A5DW75 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 379
Score = 42.7 bits (96), Expect = 0.008
Identities = 19/45 (42%), Positives = 28/45 (62%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIF 466
+CKKI+ L GAG+ S+G+P FR + GL+ N +L P A +
Sbjct: 14 KCKKIVALVGAGLLASSGLPVFRGSQ-GLWKNYNMIDLATPDAFY 57
>UniRef50_A6Q946 Cluster: Transcriptional regulator, Sir2 family;
n=1; Sulfurovum sp. NBC37-1|Rep: Transcriptional
regulator, Sir2 family - Sulfurovum sp. (strain NBC37-1)
Length = 271
Score = 42.3 bits (95), Expect = 0.011
Identities = 35/125 (28%), Positives = 61/125 (48%), Gaps = 6/125 (4%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKY-ELP-QPQAIFEINFFRQNPKPFFTLAK 517
+ ++GAG+ +G+PDFR E G ++ K EL + + + +F +P +
Sbjct: 19 LFIMAGAGMGVDSGLPDFRGVE-GFWNAYPKVRELGLRFEEMANPEWFENDPHLAWAFYG 77
Query: 518 ELFPGSFKPTISHY-FIRLLH---EKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
++ T H FI+LL+ K +T N+D + AG EE+++E HG+ +
Sbjct: 78 HRLH-LYRETEPHEGFIKLLYLANTKKYGSFVFTSNVDGQFQKAGFAEERIMECHGSIHH 136
Query: 686 SHCLD 700
CLD
Sbjct: 137 LQCLD 141
>UniRef50_A6Q178 Cluster: Transcription regulator, Sir2 family; n=1;
Nitratiruptor sp. SB155-2|Rep: Transcription regulator,
Sir2 family - Nitratiruptor sp. (strain SB155-2)
Length = 234
Score = 42.3 bits (95), Expect = 0.011
Identities = 38/121 (31%), Positives = 54/121 (44%), Gaps = 2/121 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTL 511
K I LSGAG+S +GIP FR + GL+ N+ E+ +A + +NPK F
Sbjct: 9 KNIYILSGAGLSAPSGIPTFR--DGGLWDNINIDEVATHEA------WLKNPKKVIAFFD 60
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
+ + +P +HYF L H TQN+D L AG + + HG
Sbjct: 61 QRRIELAHCQPNRAHYFFASLPN----AIHLTQNVDDLCEKAG---DNPIHLHGKLTEIR 113
Query: 692 C 694
C
Sbjct: 114 C 114
>UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium adolescentis|Rep: Sir2-type regulatory
protein - Bifidobacterium adolescentis (strain ATCC
15703 / DSM 20083)
Length = 218
Score = 42.3 bits (95), Expect = 0.011
Identities = 21/53 (39%), Positives = 27/53 (50%)
Frame = +2
Query: 539 KPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+P +H + L + GLL TQN D L AG +V HGT TSHC+
Sbjct: 32 QPGTAHKALVKLEQAGLLTLLATQNFDALHEKAGNSSNVIVNLHGTIGTSHCM 84
>UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to
ENSANGP00000025716; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000025716 - Nasonia
vitripennis
Length = 581
Score = 41.9 bits (94), Expect = 0.015
Identities = 36/121 (29%), Positives = 52/121 (42%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTL 511
R + +GAGIST+A IPD+R G++ LQ Q + I + + P
Sbjct: 109 RATSLAVYTGAGISTAASIPDYRG-TNGVWTRLQ-----QGKDIGNHDLSQAEP------ 156
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
TI+H + L++ +L +QN D L +GIP L E HG Y
Sbjct: 157 -----------TITHMALYALYKARMLKHIVSQNCDGLHLRSGIPRPLLSEVHGNMYVEV 205
Query: 692 C 694
C
Sbjct: 206 C 206
>UniRef50_A4JJP4 Cluster: Silent information regulator protein Sir2;
n=1; Burkholderia vietnamiensis G4|Rep: Silent
information regulator protein Sir2 - Burkholderia
vietnamiensis (strain G4 / LMG 22486)
(Burkholderiacepacia (strain R1808))
Length = 273
Score = 41.9 bits (94), Expect = 0.015
Identities = 37/128 (28%), Positives = 57/128 (44%), Gaps = 11/128 (8%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPE----TGLYHNLQKYELPQPQAIFEINFFRQNPKP---F 502
+I +GAG+S +G+PDFR + T L H L + ++P + + F P F
Sbjct: 21 LIIAAGAGMSVDSGLPDFRGSQGIWTTLLPHGLHERDVP---SFAQGRCFSDTPHKAWQF 77
Query: 503 FTLAKELFPGSFKPTISHYFIRLLHEKGLLLRH----YTQNIDTLERGAGIPEEKLVEAH 670
+ A E+ + T H +L + RH YT N+D + AG E +VE H
Sbjct: 78 YGRALEIC----RSTAPHAGYGILLDWARSTRHGAFVYTSNVDGQFQAAGFSEACIVECH 133
Query: 671 GTFYTSHC 694
G+ C
Sbjct: 134 GSILHFQC 141
>UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the
Sir2-like proteins precursor; n=1; Aspergillus
niger|Rep: Function: human SIRT5 belongs to the
Sir2-like proteins precursor - Aspergillus niger
Length = 258
Score = 41.9 bits (94), Expect = 0.015
Identities = 29/95 (30%), Positives = 49/95 (51%)
Frame = +2
Query: 335 CKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLA 514
C+++I L GAGIS S+G+P FR GL+ + +L P+A F+ N F++
Sbjct: 21 CRRVIALLGAGISASSGLPTFRG-AGGLWRSYDATDLATPEA-FDAN--PDLVWQFYSYR 76
Query: 515 KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNID 619
+ + + +P +HY + L K +QN+D
Sbjct: 77 RHMALKA-QPNRAHYALAELARKNKDFITLSQNVD 110
>UniRef50_Q6QGI5 Cluster: Putative Sir2-like protein; n=2;
Enterobacteria phage T5|Rep: Putative Sir2-like protein
- Bacteriophage T5
Length = 272
Score = 41.5 bits (93), Expect = 0.019
Identities = 31/116 (26%), Positives = 58/116 (50%), Gaps = 4/116 (3%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAI--FEINFFRQNPKPFFTL 511
+++I +SGAG+S +G+ FR+ Y+L + I F NF+ + +
Sbjct: 2 RRLIIISGAGLSVESGVRAFRTDTASGKALWDDYDLEEVCNIHAFRGNFYHKTHMFYNKR 61
Query: 512 AKELFPGSFKPTISHYFIRLLHEK--GLLLRHYTQNIDTLERGAGIPEEKLVEAHG 673
+EL + +P ++H I ++K G ++ + T N+D L AG+P ++ HG
Sbjct: 62 REEL--KTVEPNLAHLRIGEWYKKYPGQVV-NLTTNVDDLIERAGVPHSDILHIHG 114
>UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1;
Methylococcus capsulatus|Rep: NAD-dependent deacetylase
- Methylococcus capsulatus
Length = 255
Score = 41.5 bits (93), Expect = 0.019
Identities = 33/121 (27%), Positives = 49/121 (40%), Gaps = 2/121 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLA- 514
+ I +GAG+S +GIP FR TG + N L P+ F +P +
Sbjct: 15 RHIAVFTGAGVSAESGIPTFRDALTGFWENYDASTLASPEG------FAADPALVWGWYE 68
Query: 515 -KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
+ +P +HY I L L TQN+D L AG + + HG+ +
Sbjct: 69 WRRTRVLRAEPNPAHYAIAALAADCPRLTLITQNVDDLHERAGSADP--IRLHGSLHHPR 126
Query: 692 C 694
C
Sbjct: 127 C 127
>UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma
proteobacterium HTCC2207|Rep: NAD-dependent deacetylase
- gamma proteobacterium HTCC2207
Length = 270
Score = 40.7 bits (91), Expect = 0.034
Identities = 32/119 (26%), Positives = 57/119 (47%), Gaps = 2/119 (1%)
Frame = +2
Query: 347 ITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFF--TLAKE 520
+ L+GAG+S +G+P +R+ + G +++ P E Q + F+ L
Sbjct: 15 LVLTGAGVSAESGVPTYRN-QRG------EWQRKPPVTHQEFTGNHQARQRFWARNLVGW 67
Query: 521 LFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
F S +P +H + L + G + TQN+D L + AG +K+++ HG + CL
Sbjct: 68 RFMSSARPNGAHSALASLEKAGAVSCLVTQNVDGLHQRAG--SQKVIDLHGRVDSVSCL 124
>UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10;
Bacteria|Rep: NAD-dependent deacetylase 1 - Pseudomonas
aeruginosa
Length = 250
Score = 40.7 bits (91), Expect = 0.034
Identities = 32/121 (26%), Positives = 51/121 (42%), Gaps = 2/121 (1%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLA- 514
++++ +GAG+S +GIP FR GL+ L P A F +P +
Sbjct: 12 RRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAA------FADDPALVWGWYE 65
Query: 515 -KELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSH 691
+ L +P +H I L + R TQN+D L AG ++ HG+ +
Sbjct: 66 WRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAG--SRDVLHLHGSLHAPR 123
Query: 692 C 694
C
Sbjct: 124 C 124
>UniRef50_A4A8B4 Cluster: Silent information regulator protein Sir2;
n=1; Congregibacter litoralis KT71|Rep: Silent
information regulator protein Sir2 - Congregibacter
litoralis KT71
Length = 297
Score = 40.3 bits (90), Expect = 0.045
Identities = 32/120 (26%), Positives = 56/120 (46%), Gaps = 2/120 (1%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKEL 523
++ ++GAGIS S GIP +R E G + L+ + + + + R+ + ++ +
Sbjct: 23 VLVITGAGISVSTGIPTYRD-EKGAW--LRSNPITHQEFVAD----RRQRQRYWGRSLLG 75
Query: 524 FPG--SFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCL 697
+P KP H + L GL+ TQN+D L + AG ++ + HG CL
Sbjct: 76 WPAVRDAKPAKGHRLLAQLEHHGLVSHIVTQNVDRLHQRAG--SIRVTDLHGRLDRVRCL 133
>UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thaliana
SIR2-family protein; n=1; Yarrowia lipolytica|Rep:
Similar to tr|Q9FY91 Arabidopsis thaliana SIR2-family
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 411
Score = 40.3 bits (90), Expect = 0.045
Identities = 41/141 (29%), Positives = 59/141 (41%), Gaps = 22/141 (15%)
Frame = +2
Query: 341 KIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKE 520
K L+GAGIST++G+PD+R P TG Y + QP E K +++ A
Sbjct: 49 KTAILTGAGISTASGLPDYRGP-TGTYTTNPNH---QPTLYHEFVSDEHKRKRYWSRAWI 104
Query: 521 LFPGSFK---PTISHYFIRLLHEKGLLLRHYTQNIDTLER-------------------G 634
+ + K P ++H + G + TQN+D L +
Sbjct: 105 GYEQALKWARPNVAHEVLTGWLRGGHISGLITQNVDGLHKLSQVSGGDIVDNVNVSADLR 164
Query: 635 AGIPEEKLVEAHGTFYTSHCL 697
AG LVE HG+ Y HCL
Sbjct: 165 AGREVPALVELHGSAYRVHCL 185
>UniRef50_Q1MT39 Cluster: Novel protein similar to vertebratesirtuin
(Silent mating type information regulation 2 homolog) 7;
n=2; Danio rerio|Rep: Novel protein similar to
vertebratesirtuin (Silent mating type information
regulation 2 homolog) 7 - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 376
Score = 39.9 bits (89), Expect = 0.059
Identities = 18/35 (51%), Positives = 25/35 (71%)
Frame = +2
Query: 332 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQK 436
R K ++ +GAGIST+A IPD+R P G++ LQK
Sbjct: 95 RAKHLVIYTGAGISTAASIPDYRGP-NGVWTQLQK 128
>UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococcus
xanthus DK 1622|Rep: NAD-dependent deacetylase -
Myxococcus xanthus (strain DK 1622)
Length = 245
Score = 39.9 bits (89), Expect = 0.059
Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 6/123 (4%)
Frame = +2
Query: 344 IITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPF--FTLAK 517
++ L+GAG+S +G+P FR +GL+ + + P+ FR++P F +
Sbjct: 12 LLVLTGAGVSAESGVPTFRG-MSGLWEDQPVEAVASPEG------FRKDPALVWRFYSER 64
Query: 518 ELFPGSFKPTISHYFI----RLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYT 685
+ P H + R L ++ LL TQN+D L AG +++VE HG +
Sbjct: 65 RKAAAAVHPNPGHEALVAWERHLGDRFLLA---TQNVDGLHTRAG--SQRVVEMHGNLFK 119
Query: 686 SHC 694
+ C
Sbjct: 120 TRC 122
>UniRef50_A3U6J8 Cluster: Beta-ketoacyl synthase; n=3;
Flavobacteriaceae|Rep: Beta-ketoacyl synthase -
Croceibacter atlanticus HTCC2559
Length = 381
Score = 39.5 bits (88), Expect = 0.078
Identities = 30/121 (24%), Positives = 60/121 (49%), Gaps = 8/121 (6%)
Frame = +2
Query: 353 LSGAGISTSAGIPDFRSPETGL--YHNLQKYELPQ-----PQAIFEINFFRQNPKPFFTL 511
+S G S+ A + + ++ +GL H+ + ++ P + I E +F + N K +T+
Sbjct: 12 ISSLGFSSKAVVSNIKNEVSGLKKLHDKELFQEPFYTSVINKEILETSFSKLNAKHDYTV 71
Query: 512 AKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEK-LVEAHGTFYTS 688
+++ S + TI+ + L + G+++ NID L+ PEE+ + + G TS
Sbjct: 72 LEKMMIVSLQDTINTANLNLDEKVGIIISTTKGNIDVLDNANPFPEERAYLSSLGKTITS 131
Query: 689 H 691
H
Sbjct: 132 H 132
>UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Helicobacter
pylori (Campylobacter pylori)
Length = 229
Score = 39.5 bits (88), Expect = 0.078
Identities = 34/119 (28%), Positives = 56/119 (47%), Gaps = 7/119 (5%)
Frame = +2
Query: 338 KKIITLSGAGISTSAGIPDFRSPETGLY--HNLQKYELP-----QPQAIFEINFFRQNPK 496
K ++ LSGAGIS +GI FR + GL+ H++ + P PQ + ++F+ Q +
Sbjct: 2 KNLVILSGAGISAESGIKTFRDAD-GLWEGHDIMEVASPYGWKKNPQKV--LDFYNQRRR 58
Query: 497 PFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHG 673
F E++P ++ EK + TQN+D L AG +++ HG
Sbjct: 59 QLF----EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAG--SSRILHLHG 105
>UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2;
Actinobacteria (class)|Rep: Regulatory protein, Sir2
family - Leifsonia xyli subsp. xyli
Length = 283
Score = 39.1 bits (87), Expect = 0.10
Identities = 36/144 (25%), Positives = 62/144 (43%)
Frame = +2
Query: 266 EPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYEL 445
EP L G+ + ++ ++ L+GAG+ST +GIPD+R ++ +
Sbjct: 4 EPSGSALSAELARGLDQTVEVLSGRRFAVLTGAGVSTDSGIPDYRGEGAP-----KRTPM 58
Query: 446 PQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTL 625
Q + E + R+ L F + +P H + L + G TQN+D L
Sbjct: 59 TFQQFLAE-DRHRKRYWAGSHLGYRRFSAA-RPNDGHRALAALEDAGAAAGVVTQNVDGL 116
Query: 626 ERGAGIPEEKLVEAHGTFYTSHCL 697
+ AG ++V+ HG+ CL
Sbjct: 117 HKKAG--SRRVVDLHGSVDRVLCL 138
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 734,327,158
Number of Sequences: 1657284
Number of extensions: 15852020
Number of successful extensions: 42514
Number of sequences better than 10.0: 284
Number of HSP's better than 10.0 without gapping: 40844
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 42350
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 55785129165
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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