Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte22l20
(717 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 170 5e-42
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 168 1e-41
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 168 1e-41
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 168 1e-41
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 168 1e-41
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 168 1e-41
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 167 3e-41
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 166 6e-41
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 166 6e-41
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 165 1e-40
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 162 1e-39
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 123 6e-28
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 122 1e-27
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 118 3e-26
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 118 3e-26
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 118 3e-26
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 118 3e-26
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 116 6e-26
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 116 6e-26
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 77 5e-14
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 73 1e-12
X90568-1|CAA62188.1|26926|Homo sapiens titin protein. 31 4.1
AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein. 31 4.1
AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein. 31 4.1
M81601-1|AAA61138.1| 301|Homo sapiens transcription elongation ... 30 9.5
BC105696-1|AAI05697.1| 376|Homo sapiens KLHL30 protein protein. 30 9.5
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 170 bits (413), Expect = 5e-42
Identities = 81/165 (49%), Positives = 109/165 (66%), Gaps = 6/165 (3%)
Frame = +3
Query: 207 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 383
+E G L + L IF VNL HIESR S RR +E V+C+ L LK +
Sbjct: 24 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDILHLLKSHTN 83
Query: 384 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 551
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 84 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 143
Query: 552 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRALP-HSC 683
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF+E+++ P H+C
Sbjct: 144 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHAC 188
Score = 31.1 bits (67), Expect = 4.1
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +1
Query: 655 KLTELYPTHACKEHNHVFPLL 717
+L +LYPTHAC+E+ PLL
Sbjct: 178 ELNKLYPTHACREYLKNLPLL 198
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 168 bits (409), Expect = 1e-41
Identities = 80/165 (48%), Positives = 108/165 (65%), Gaps = 6/165 (3%)
Frame = +3
Query: 207 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 383
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 384 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 551
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 552 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRALP-HSC 683
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF+E+++ P H+C
Sbjct: 146 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHAC 190
Score = 31.1 bits (67), Expect = 4.1
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +1
Query: 655 KLTELYPTHACKEHNHVFPLL 717
+L +LYPTHAC+E+ PLL
Sbjct: 180 ELNKLYPTHACREYLKNLPLL 200
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 168 bits (409), Expect = 1e-41
Identities = 88/187 (47%), Positives = 123/187 (65%), Gaps = 4/187 (2%)
Frame = +3
Query: 141 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 317
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 318 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 491
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 492 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRAL 671
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ +
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 672 -PHSCLQ 689
H+C +
Sbjct: 199 KTHACYE 205
Score = 37.1 bits (82), Expect = 0.063
Identities = 14/20 (70%), Positives = 16/20 (80%)
Frame = +1
Query: 658 LTELYPTHACKEHNHVFPLL 717
L LY THAC E+NH+FPLL
Sbjct: 194 LKSLYKTHACYEYNHIFPLL 213
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 168 bits (409), Expect = 1e-41
Identities = 88/187 (47%), Positives = 123/187 (65%), Gaps = 4/187 (2%)
Frame = +3
Query: 141 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 317
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 318 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 491
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 492 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRAL 671
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ +
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 672 -PHSCLQ 689
H+C +
Sbjct: 199 KTHACYE 205
Score = 37.1 bits (82), Expect = 0.063
Identities = 14/20 (70%), Positives = 16/20 (80%)
Frame = +1
Query: 658 LTELYPTHACKEHNHVFPLL 717
L LY THAC E+NH+FPLL
Sbjct: 194 LKSLYKTHACYEYNHIFPLL 213
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 168 bits (409), Expect = 1e-41
Identities = 80/165 (48%), Positives = 108/165 (65%), Gaps = 6/165 (3%)
Frame = +3
Query: 207 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 383
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 384 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 551
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 552 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRALP-HSC 683
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF+E+++ P H+C
Sbjct: 146 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHAC 190
Score = 31.1 bits (67), Expect = 4.1
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +1
Query: 655 KLTELYPTHACKEHNHVFPLL 717
+L +LYPTHAC+E+ PLL
Sbjct: 180 ELNKLYPTHACREYLKNLPLL 200
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 168 bits (409), Expect = 1e-41
Identities = 88/187 (47%), Positives = 123/187 (65%), Gaps = 4/187 (2%)
Frame = +3
Query: 141 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 317
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 318 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 491
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 492 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRAL 671
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ +
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 672 -PHSCLQ 689
H+C +
Sbjct: 199 KTHACYE 205
Score = 37.1 bits (82), Expect = 0.063
Identities = 14/20 (70%), Positives = 16/20 (80%)
Frame = +1
Query: 658 LTELYPTHACKEHNHVFPLL 717
L LY THAC E+NH+FPLL
Sbjct: 194 LKSLYKTHACYEYNHIFPLL 213
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 167 bits (406), Expect = 3e-41
Identities = 90/216 (41%), Positives = 127/216 (58%), Gaps = 6/216 (2%)
Frame = +3
Query: 54 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARY 233
E+ + + + +P SG DK +G N RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGN--KGSNK-REAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 234 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 404
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 405 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 578
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 579 YKHGEPLPYVEYTKEEVATWGVVFREVDRALP-HSC 683
YK+G+P+P VEYT+EE TWGVVFRE+ + P H+C
Sbjct: 201 YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHAC 236
Score = 33.9 bits (74), Expect = 0.58
Identities = 13/21 (61%), Positives = 18/21 (85%)
Frame = +1
Query: 655 KLTELYPTHACKEHNHVFPLL 717
+L++LYPTHAC+E+ FPLL
Sbjct: 226 ELSKLYPTHACREYLKNFPLL 246
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 166 bits (404), Expect = 6e-41
Identities = 89/210 (42%), Positives = 124/210 (59%), Gaps = 6/210 (2%)
Frame = +3
Query: 72 TAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSS 251
T ++ +P SG DK G+ RE + T ++ S +E G L + L +F
Sbjct: 38 TFLKLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQE 92
Query: 252 HGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISRNYKDNR 422
VN+ HIESR S RR E V+CE G +F ++ LK + LN + +
Sbjct: 93 KRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEE 152
Query: 423 SA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEP 596
VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A YK+G+P
Sbjct: 153 ELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQP 212
Query: 597 LPYVEYTKEEVATWGVVFREVDRALP-HSC 683
+P VEYT+EE TWGVVFRE+ + P H+C
Sbjct: 213 IPRVEYTEEETKTWGVVFRELSKLYPTHAC 242
Score = 33.9 bits (74), Expect = 0.58
Identities = 13/21 (61%), Positives = 18/21 (85%)
Frame = +1
Query: 655 KLTELYPTHACKEHNHVFPLL 717
+L++LYPTHAC+E+ FPLL
Sbjct: 232 ELSKLYPTHACREYLKNFPLL 252
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 166 bits (404), Expect = 6e-41
Identities = 89/216 (41%), Positives = 126/216 (58%), Gaps = 6/216 (2%)
Frame = +3
Query: 54 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARY 233
E+ + + + +P SG DK G+ RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 234 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 404
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 405 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 578
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 579 YKHGEPLPYVEYTKEEVATWGVVFREVDRALP-HSC 683
YK+G+P+P VEYT+EE TWGVVFRE+ + P H+C
Sbjct: 201 YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHAC 236
Score = 33.9 bits (74), Expect = 0.58
Identities = 13/21 (61%), Positives = 18/21 (85%)
Frame = +1
Query: 655 KLTELYPTHACKEHNHVFPLL 717
+L++LYPTHAC+E+ FPLL
Sbjct: 226 ELSKLYPTHACREYLKNFPLL 246
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 165 bits (402), Expect = 1e-40
Identities = 87/187 (46%), Positives = 122/187 (65%), Gaps = 4/187 (2%)
Frame = +3
Query: 141 NYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 317
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 318 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 491
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 492 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRAL 671
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +E TWG VF+ +
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLY 198
Query: 672 -PHSCLQ 689
H+C +
Sbjct: 199 KTHACYE 205
Score = 37.1 bits (82), Expect = 0.063
Identities = 14/20 (70%), Positives = 16/20 (80%)
Frame = +1
Query: 658 LTELYPTHACKEHNHVFPLL 717
L LY THAC E+NH+FPLL
Sbjct: 194 LKSLYKTHACYEYNHIFPLL 213
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 162 bits (393), Expect = 1e-39
Identities = 78/165 (47%), Positives = 107/165 (64%), Gaps = 6/165 (3%)
Frame = +3
Query: 207 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 383
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQLNDIFHLLKSHTN 85
Query: 384 YLNIISR-NY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 551
L++ N+ ++ +VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVTPPDNFTMKEEGMESVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 552 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFREVDRALP-HSC 683
KYFAD A +YK+G+P+P VE+T+EE+ TWG VFRE+++ P H+C
Sbjct: 146 KYFADSAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHAC 190
Score = 31.1 bits (67), Expect = 4.1
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +1
Query: 655 KLTELYPTHACKEHNHVFPLL 717
+L +LYPTHAC+E+ PLL
Sbjct: 180 ELNKLYPTHACREYLKNLPLL 200
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 123 bits (297), Expect = 6e-28
Identities = 71/187 (37%), Positives = 102/187 (54%), Gaps = 5/187 (2%)
Frame = +3
Query: 54 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARY 233
E+ + + + +P SG DK G+ RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 234 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 404
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 405 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 578
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 579 YKHGEPL 599
YK+G L
Sbjct: 201 YKYGPRL 207
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 122 bits (295), Expect = 1e-27
Identities = 62/131 (47%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
Frame = +3
Query: 207 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 383
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 384 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 551
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLNEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 552 KYFADIAYNYK 584
KYFAD+A NYK
Sbjct: 146 KYFADLAMNYK 156
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 118 bits (283), Expect = 3e-26
Identities = 61/161 (37%), Positives = 94/161 (58%), Gaps = 5/161 (3%)
Frame = +3
Query: 183 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 350
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 111 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 169
Query: 351 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 527
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 170 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 222
Query: 528 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVF 650
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+
Sbjct: 223 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVY 263
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 118 bits (283), Expect = 3e-26
Identities = 61/161 (37%), Positives = 94/161 (58%), Gaps = 5/161 (3%)
Frame = +3
Query: 183 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 350
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 351 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 527
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 528 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVF 650
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVY 236
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 118 bits (283), Expect = 3e-26
Identities = 61/161 (37%), Positives = 94/161 (58%), Gaps = 5/161 (3%)
Frame = +3
Query: 183 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 350
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 115 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 173
Query: 351 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 527
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 174 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 226
Query: 528 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVF 650
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+
Sbjct: 227 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVY 267
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 118 bits (283), Expect = 3e-26
Identities = 61/161 (37%), Positives = 94/161 (58%), Gaps = 5/161 (3%)
Frame = +3
Query: 183 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 350
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 351 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 527
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 528 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVF 650
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVY 236
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 116 bits (280), Expect = 6e-26
Identities = 60/157 (38%), Positives = 92/157 (58%), Gaps = 5/157 (3%)
Frame = +3
Query: 183 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 350
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 88 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 146
Query: 351 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 527
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 147 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 199
Query: 528 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 638
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 200 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 236
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 116 bits (280), Expect = 6e-26
Identities = 60/157 (38%), Positives = 92/157 (58%), Gaps = 5/157 (3%)
Frame = +3
Query: 183 LLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 350
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 351 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 527
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 528 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 638
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 232
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 77.4 bits (182), Expect = 5e-14
Identities = 30/45 (66%), Positives = 37/45 (82%)
Frame = +3
Query: 504 DSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 638
D DHPGF+D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 45
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 72.9 bits (171), Expect = 1e-12
Identities = 29/44 (65%), Positives = 36/44 (81%)
Frame = +3
Query: 504 DSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVAT 635
D DHPGF+D VYR RRK A+IA+ Y+HG+P+P VEYT EE+AT
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
>X90568-1|CAA62188.1|26926|Homo sapiens titin protein.
Length = 26926
Score = 31.1 bits (67), Expect = 4.1
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 120 PKLMEGG----NYIREGRDSTKSTWLLIS 194
P L++GG NY+ E RD+TK TW ++S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
>AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein.
Length = 30000
Score = 31.1 bits (67), Expect = 4.1
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 120 PKLMEGG----NYIREGRDSTKSTWLLIS 194
P L++GG NY+ E RD+TK TW ++S
Sbjct: 28315 PPLIDGGSPIINYVIEKRDATKRTWSVVS 28343
>AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein.
Length = 26926
Score = 31.1 bits (67), Expect = 4.1
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 120 PKLMEGG----NYIREGRDSTKSTWLLIS 194
P L++GG NY+ E RD+TK TW ++S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
>M81601-1|AAA61138.1| 301|Homo sapiens transcription elongation
factor SII protein.
Length = 301
Score = 29.9 bits (64), Expect = 9.5
Identities = 17/61 (27%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Frame = +3
Query: 45 PATEKEMDITAKQIEQPTSGSPPDKPKLMEGGNYI-REGRDSTKSTWLLISPVAPDEAGS 221
P+TEK++D K+ + SP + + GN R+ + + T+L P AP + S
Sbjct: 80 PSTEKDLDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYLSSFPRAPSTSDS 139
Query: 222 L 224
+
Sbjct: 140 V 140
>BC105696-1|AAI05697.1| 376|Homo sapiens KLHL30 protein protein.
Length = 376
Score = 29.9 bits (64), Expect = 9.5
Identities = 15/36 (41%), Positives = 21/36 (58%)
Frame = -1
Query: 225 LTSQPRRVRLVKSEAKLIW*NHDPRGCSCHLPSILA 118
L QP + RL EA + W HDP+ + HLP +L+
Sbjct: 170 LQVQPEQSRL---EALMRWVRHDPQARAVHLPELLS 202
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 125,685,221
Number of Sequences: 237096
Number of extensions: 3068409
Number of successful extensions: 8492
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 7860
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8476
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8399192100
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -