Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte22j03
(748 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
M23294-1|AAA52645.1| 556|Homo sapiens beta-hexosaminidase beta-... 68 4e-11
M19735-1|AAA68620.1| 544|Homo sapiens beta-hexosaminidase beta-... 68 4e-11
M13519-1|AAA51828.1| 572|Homo sapiens HEXB protein. 68 4e-11
BT009919-1|AAP88921.1| 556|Homo sapiens hexosaminidase B (beta ... 68 4e-11
BC017378-1|AAH17378.1| 556|Homo sapiens hexosaminidase B (beta ... 68 4e-11
AF378118-1|AAM46114.1| 556|Homo sapiens cervical cancer proto-o... 68 4e-11
S62076-1|AAD13932.1| 529|Homo sapiens HEXA protein. 47 8e-05
M16424-1|AAB00965.1| 529|Homo sapiens HEXA protein. 47 8e-05
BC084537-1|AAH84537.1| 529|Homo sapiens hexosaminidase A (alpha... 47 8e-05
BC018927-1|AAH18927.1| 529|Homo sapiens hexosaminidase A (alpha... 47 8e-05
AK222502-1|BAD96222.1| 529|Homo sapiens hexosaminidase A prepro... 47 8e-05
M13520-1|AAA51827.1| 490|Homo sapiens HEXA protein. 46 1e-04
BC001138-1|AAH01138.2| 409|Homo sapiens HEXA protein protein. 43 0.001
>M23294-1|AAA52645.1| 556|Homo sapiens beta-hexosaminidase
beta-subunit protein.
Length = 556
Score = 67.7 bits (158), Expect = 4e-11
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 1/176 (0%)
Frame = +2
Query: 182 GPQLWPYPIGYTLFSKNL-VAMSILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKI 358
GP LWP P+ + L +A + + S + L EAF+ + G + K
Sbjct: 53 GPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTL-LEEAFRRYHGYIFGFYKW 111
Query: 359 GREMKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCG 538
E V+++ + I ++++ D +++DE+YT+ V + + L ++ G
Sbjct: 112 HHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEP---VAV-LKANRVWG 167
Query: 539 ARHGLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLMK 706
A GLET +Q++ D + I S II D+P +RG++IDT R+Y+P+ ++K
Sbjct: 168 ALRGLETFSQLVYQDSYGTFTINESTII--DSPRFSHRGILIDTSRHYLPVKIILK 221
>M19735-1|AAA68620.1| 544|Homo sapiens beta-hexosaminidase
beta-subunit protein.
Length = 544
Score = 67.7 bits (158), Expect = 4e-11
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 1/176 (0%)
Frame = +2
Query: 182 GPQLWPYPIGYTLFSKNL-VAMSILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKI 358
GP LWP P+ + L +A + + S + L EAF+ + G + K
Sbjct: 41 GPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTL-LEEAFRRYHGYIFGFYKW 99
Query: 359 GREMKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCG 538
E V+++ + I ++++ D +++DE+YT+ V + + L ++ G
Sbjct: 100 HHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEP---VAV-LKANRVWG 155
Query: 539 ARHGLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLMK 706
A GLET +Q++ D + I S II D+P +RG++IDT R+Y+P+ ++K
Sbjct: 156 ALRGLETFSQLVYQDSYGTFTINESTII--DSPRFSHRGILIDTSRHYLPVKIILK 209
>M13519-1|AAA51828.1| 572|Homo sapiens HEXB protein.
Length = 572
Score = 67.7 bits (158), Expect = 4e-11
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 1/176 (0%)
Frame = +2
Query: 182 GPQLWPYPIGYTLFSKNL-VAMSILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKI 358
GP LWP P+ + L +A + + S + L EAF+ + G + K
Sbjct: 69 GPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTL-LEEAFRRYHGYIFGFYKW 127
Query: 359 GREMKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCG 538
E V+++ + I ++++ D +++DE+YT+ V + + L ++ G
Sbjct: 128 HHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEP---VAV-LKANRVWG 183
Query: 539 ARHGLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLMK 706
A GLET +Q++ D + I S II D+P +RG++IDT R+Y+P+ ++K
Sbjct: 184 ALRGLETFSQLVYQDSYGTFTINESTII--DSPRFSHRGILIDTSRHYLPVKIILK 237
>BT009919-1|AAP88921.1| 556|Homo sapiens hexosaminidase B (beta
polypeptide) protein.
Length = 556
Score = 67.7 bits (158), Expect = 4e-11
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 1/176 (0%)
Frame = +2
Query: 182 GPQLWPYPIGYTLFSKNL-VAMSILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKI 358
GP LWP P+ + L +A + + S + L EAF+ + G + K
Sbjct: 53 GPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTL-LEEAFRRYHGYIFGFYKW 111
Query: 359 GREMKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCG 538
E V+++ + I ++++ D +++DE+YT+ V + + L ++ G
Sbjct: 112 HHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEP---VAV-LKANRVWG 167
Query: 539 ARHGLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLMK 706
A GLET +Q++ D + I S II D+P +RG++IDT R+Y+P+ ++K
Sbjct: 168 ALRGLETFSQLVYQDSYGTFTINESTII--DSPRFSHRGILIDTSRHYLPVKIILK 221
>BC017378-1|AAH17378.1| 556|Homo sapiens hexosaminidase B (beta
polypeptide) protein.
Length = 556
Score = 67.7 bits (158), Expect = 4e-11
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 1/176 (0%)
Frame = +2
Query: 182 GPQLWPYPIGYTLFSKNL-VAMSILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKI 358
GP LWP P+ + L +A + + S + L EAF+ + G + K
Sbjct: 53 GPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTL-LEEAFRRYHGYIFGFYKW 111
Query: 359 GREMKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCG 538
E V+++ + I ++++ D +++DE+YT+ V + + L ++ G
Sbjct: 112 HHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEP---VAV-LKANRVWG 167
Query: 539 ARHGLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLMK 706
A GLET +Q++ D + I S II D+P +RG++IDT R+Y+P+ ++K
Sbjct: 168 ALRGLETFSQLVYQDSYGTFTINESTII--DSPRFSHRGILIDTSRHYLPVKIILK 221
>AF378118-1|AAM46114.1| 556|Homo sapiens cervical cancer
proto-oncogene 7 protein.
Length = 556
Score = 67.7 bits (158), Expect = 4e-11
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 1/176 (0%)
Frame = +2
Query: 182 GPQLWPYPIGYTLFSKNL-VAMSILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKI 358
GP LWP P+ + L +A + + S + L EAF+ + G + K
Sbjct: 53 GPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTL-LEEAFRRYHGYIFGFYKW 111
Query: 359 GREMKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCG 538
E V+++ + I ++++ D +++DE+YT+ V + + L ++ G
Sbjct: 112 HHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEP---VAV-LKANRVWG 167
Query: 539 ARHGLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLMK 706
A GLET +Q++ D + I S II D+P +RG++IDT R+Y+P+ ++K
Sbjct: 168 ALRGLETFSQLVYQDSYGTFTINESTII--DSPRFSHRGILIDTSRHYLPVKIILK 221
>S62076-1|AAD13932.1| 529|Homo sapiens HEXA protein.
Length = 529
Score = 46.8 bits (106), Expect = 8e-05
Identities = 41/172 (23%), Positives = 74/172 (43%), Gaps = 1/172 (0%)
Frame = +2
Query: 191 LWPYPIGYTLFSKNLVAM-SILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKIGRE 367
LWP+P + + V + + +Y S L EAF+ + L R
Sbjct: 23 LWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV-LDEAFQRYRDLLFGSGSWPRP 81
Query: 368 MKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCGARH 547
G K + ++ + + L + E YT+++N + L S + GA
Sbjct: 82 YLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDD----QCLLLSETVWGALR 137
Query: 548 GLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLM 703
GLET +Q++ + I + I +D P +RGL++DT R+Y+P+ ++
Sbjct: 138 GLETFSQLVWKSAEGTFFINKTEI--EDFPRFPHRGLLLDTSRHYLPLSSIL 187
>M16424-1|AAB00965.1| 529|Homo sapiens HEXA protein.
Length = 529
Score = 46.8 bits (106), Expect = 8e-05
Identities = 41/172 (23%), Positives = 74/172 (43%), Gaps = 1/172 (0%)
Frame = +2
Query: 191 LWPYPIGYTLFSKNLVAM-SILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKIGRE 367
LWP+P + + V + + +Y S L EAF+ + L R
Sbjct: 23 LWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV-LDEAFQRYRDLLFGSGSWPRP 81
Query: 368 MKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCGARH 547
G K + ++ + + L + E YT+++N + L S + GA
Sbjct: 82 YLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDD----QCLLLSETVWGALR 137
Query: 548 GLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLM 703
GLET +Q++ + I + I +D P +RGL++DT R+Y+P+ ++
Sbjct: 138 GLETFSQLVWKSAEGTFFINKTEI--EDFPRFPHRGLLLDTSRHYLPLSSIL 187
>BC084537-1|AAH84537.1| 529|Homo sapiens hexosaminidase A (alpha
polypeptide) protein.
Length = 529
Score = 46.8 bits (106), Expect = 8e-05
Identities = 41/172 (23%), Positives = 74/172 (43%), Gaps = 1/172 (0%)
Frame = +2
Query: 191 LWPYPIGYTLFSKNLVAM-SILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKIGRE 367
LWP+P + + V + + +Y S L EAF+ + L R
Sbjct: 23 LWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV-LDEAFQRYRDLLFGSGSWPRP 81
Query: 368 MKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCGARH 547
G K + ++ + + L + E YT+++N + L S + GA
Sbjct: 82 YLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDD----QCLLLSETVWGALR 137
Query: 548 GLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLM 703
GLET +Q++ + I + I +D P +RGL++DT R+Y+P+ ++
Sbjct: 138 GLETFSQLVWKSAEGTFFINKTEI--EDFPRFPHRGLLLDTSRHYLPLSSIL 187
>BC018927-1|AAH18927.1| 529|Homo sapiens hexosaminidase A (alpha
polypeptide) protein.
Length = 529
Score = 46.8 bits (106), Expect = 8e-05
Identities = 41/172 (23%), Positives = 74/172 (43%), Gaps = 1/172 (0%)
Frame = +2
Query: 191 LWPYPIGYTLFSKNLVAM-SILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKIGRE 367
LWP+P + + V + + +Y S L EAF+ + L R
Sbjct: 23 LWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV-LDEAFQRYRDLLFGSGSWPRP 81
Query: 368 MKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCGARH 547
G K + ++ + + L + E YT+++N + L S + GA
Sbjct: 82 YLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDD----QCLLLSETVWGALR 137
Query: 548 GLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLM 703
GLET +Q++ + I + I +D P +RGL++DT R+Y+P+ ++
Sbjct: 138 GLETFSQLVWKSAEGTFFINKTEI--EDFPRFPHRGLLLDTSRHYLPLSSIL 187
>AK222502-1|BAD96222.1| 529|Homo sapiens hexosaminidase A
preproprotein variant protein.
Length = 529
Score = 46.8 bits (106), Expect = 8e-05
Identities = 41/172 (23%), Positives = 74/172 (43%), Gaps = 1/172 (0%)
Frame = +2
Query: 191 LWPYPIGYTLFSKNLVAM-SILKLEYKFQSLPSENVHRHLAEAFKLFIGDLARLEKIGRE 367
LWP+P + + V + + +Y S L EAF+ + L R
Sbjct: 23 LWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV-LDEAFQRYRDLLFGSGSWPRP 81
Query: 368 MKNGTCDLPVKKMNIIIDIETDPDPRLRLNTDEAYTISVNSNFDFITIHLSSSSFCGARH 547
G K + ++ + + L + E YT+++N + L S + GA
Sbjct: 82 YLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDD----QCLLLSETVWGALR 137
Query: 548 GLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLM 703
GLET +Q++ + I + I +D P +RGL++DT R+Y+P+ ++
Sbjct: 138 GLETFSQLVWKSAEGTFFINKTEI--EDFPRFPHRGLLLDTSRHYLPLSSIL 187
>M13520-1|AAA51827.1| 490|Homo sapiens HEXA protein.
Length = 490
Score = 46.4 bits (105), Expect = 1e-04
Identities = 29/104 (27%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Frame = +2
Query: 395 VKKMNIIIDIETDPDPRL-RLNTDEAYTISVNSNFDFITIHLSSSSFCGARHGLETLNQM 571
++K +++ + T +L L + E YT+++N + L S + GA GLET +Q+
Sbjct: 51 LEKNVLVVSVVTPGCNQLPTLESVENYTLTINDD----QCLLLSETVWGALRGLETFSQL 106
Query: 572 ILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMPDLM 703
+ + I + I +D P +RGL++DT R+Y+P+ ++
Sbjct: 107 VWKSAEGTFFINKTEI--EDFPRFPHRGLLLDTSRHYLPLSSIL 148
>BC001138-1|AAH01138.2| 409|Homo sapiens HEXA protein protein.
Length = 409
Score = 42.7 bits (96), Expect = 0.001
Identities = 21/63 (33%), Positives = 36/63 (57%)
Frame = +2
Query: 515 LSSSSFCGARHGLETLNQMILLDQLTGYLITLSHIIVKDAPSHKYRGLMIDTGRNYIPMP 694
L S + GA GLET +Q++ + I + I +D P +RGL++DT R+Y+P+
Sbjct: 7 LLSETVWGALRGLETFSQLVWKSAEGTFFINKTEI--EDFPRFPHRGLLLDTSRHYLPLS 64
Query: 695 DLM 703
++
Sbjct: 65 SIL 67
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 105,968,559
Number of Sequences: 237096
Number of extensions: 2172838
Number of successful extensions: 3823
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 3659
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3805
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8959138240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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