Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmte22e07
(769 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16I97 Cluster: Putative uncharacterized protein; n=4; ... 115 1e-24
UniRef50_Q9H300 Cluster: Presenilins-associated rhomboid-like pr... 102 9e-21
UniRef50_Q3B8P0 Cluster: Presenilins-associated rhomboid-like pr... 99 6e-20
UniRef50_Q9H300-2 Cluster: Isoform 2 of Q9H300 ; n=10; Eutheria|... 92 1e-17
UniRef50_UPI00015B5442 Cluster: PREDICTED: similar to conserved ... 89 8e-17
UniRef50_Q4SB14 Cluster: Chromosome undetermined SCAF14677, whol... 81 2e-14
UniRef50_Q8MQY3 Cluster: RH66343p; n=4; Diptera|Rep: RH66343p - ... 79 9e-14
UniRef50_Q58EK4 Cluster: Presenilins-associated rhomboid-like pr... 69 1e-10
UniRef50_UPI000155573E Cluster: PREDICTED: hypothetical protein,... 48 2e-04
UniRef50_Q8I2Y1 Cluster: Putative uncharacterized protein PFI084... 35 1.9
UniRef50_Q4P592 Cluster: Putative uncharacterized protein; n=1; ... 34 4.5
UniRef50_A5E2I4 Cluster: Predicted protein; n=1; Lodderomyces el... 33 5.9
UniRef50_A6PV62 Cluster: Putative glycosyl hydrolase precursor; ... 33 7.8
UniRef50_Q22WI6 Cluster: Rhomboid family protein; n=1; Tetrahyme... 33 7.8
>UniRef50_Q16I97 Cluster: Putative uncharacterized protein; n=4;
Coelomata|Rep: Putative uncharacterized protein - Aedes
aegypti (Yellowfever mosquito)
Length = 362
Score = 115 bits (276), Expect = 1e-24
Identities = 68/189 (35%), Positives = 94/189 (49%), Gaps = 15/189 (7%)
Frame = +2
Query: 188 NICKPPLFNQVWLPPKNG-----RLIRNSFHNSKRGSRQALKPDPLENLHIETGP-LHAK 349
N C+ PL N ++ R +RN+ +Q + P L+ IE+G +
Sbjct: 22 NFCQRPLLNPSQFAHRSSLLRYSRQMRNNTRGESFAPKQTIVPTGLQGAAIESGGYIDPS 81
Query: 350 GLVKPLIFTVGVSAASLLGCVIWEYENLRVHASSLLRRPGT--WLTAQQKKSKSEPGPLK 523
L K +FTV SA S +G IWEYE +R A LR W + K + E +
Sbjct: 82 RLWKSFVFTVAFSAGSFVGVTIWEYETVRSRAMDALRAKLNLNWFRERMKDKRREVEQWR 141
Query: 524 K----WWNSLRDNEKVFYPILAANLLVFGAWRIRALQPFMVKYFCSNPSGGAVCLPMVL- 688
K WW+ L E++F PI A N++VFG WRI LQP M++ F SNP+ AVC PM L
Sbjct: 142 KDVNGWWSKLSPGERIFAPICALNVVVFGLWRIPQLQPMMLRLFASNPAAKAVCWPMFLS 201
Query: 689 --SHSAIIH 709
SH ++ H
Sbjct: 202 TFSHYSLFH 210
Score = 37.5 bits (83), Expect = 0.36
Identities = 16/26 (61%), Positives = 20/26 (76%)
Frame = +1
Query: 691 TFSHYSPLHLAANMYVLYSXXPAALS 768
TFSHYS H+AANMYVL+S A++
Sbjct: 202 TFSHYSLFHIAANMYVLHSFCHGAVA 227
>UniRef50_Q9H300 Cluster: Presenilins-associated rhomboid-like
protein, mitochondrial precursor (EC 3.4.21.105)
(Mitochondrial intramembrane cleaving protease PARL)
[Contains: P-beta (Pbeta)]; n=12; Euteleostomi|Rep:
Presenilins-associated rhomboid-like protein,
mitochondrial precursor (EC 3.4.21.105) (Mitochondrial
intramembrane cleaving protease PARL) [Contains: P-beta
(Pbeta)] - Homo sapiens (Human)
Length = 379
Score = 102 bits (245), Expect = 9e-21
Identities = 53/147 (36%), Positives = 81/147 (55%), Gaps = 5/147 (3%)
Frame = +2
Query: 284 RQALKPDPLENLHIETGPLHAKGLVKPLIFTVGVSAASLLGCVIWEYENLRVHASSLLRR 463
R AL P P+E P + L+KPL FTVG + + IW+YE+L+ S
Sbjct: 76 RSALIP-PVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDG 134
Query: 464 -PGTWLTAQQKKSKSE-PGPLKKWWNSLRDNEKVFYPILAANLLVFGAWRIRALQPFMVK 637
WL + + + + + + KWWN+L D ++ I+AAN+LVF WR+ +LQ M++
Sbjct: 135 IKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIR 194
Query: 638 YFCSNPSGGAVCLPMVL---SHSAIIH 709
YF SNP+ +C PM+L SH ++ H
Sbjct: 195 YFTSNPASKVLCSPMLLSTFSHFSLFH 221
Score = 35.1 bits (77), Expect = 1.9
Identities = 14/19 (73%), Positives = 17/19 (89%)
Frame = +1
Query: 691 TFSHYSPLHLAANMYVLYS 747
TFSH+S H+AANMYVL+S
Sbjct: 213 TFSHFSLFHMAANMYVLWS 231
>UniRef50_Q3B8P0 Cluster: Presenilins-associated rhomboid-like
protein, mitochondrial precursor (EC 3.4.21.105)
(Mitochondrial intramembrane-cleaving protease PARL)
[Contains: P-beta (Pbeta)]; n=15; Euteleostomi|Rep:
Presenilins-associated rhomboid-like protein,
mitochondrial precursor (EC 3.4.21.105) (Mitochondrial
intramembrane-cleaving protease PARL) [Contains: P-beta
(Pbeta)] - Rattus norvegicus (Rat)
Length = 377
Score = 99 bits (238), Expect = 6e-20
Identities = 54/147 (36%), Positives = 78/147 (53%), Gaps = 5/147 (3%)
Frame = +2
Query: 284 RQALKPDPLENLHIETGPLHAKGLVKPLIFTVGVSAASLLGCVIWEYENLRVHASSLLRR 463
R AL P PLE P + L+KP FTVG + + IW+YE+L+ S
Sbjct: 74 RSALIP-PLEETVFYPSPYPVRTLLKPFFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDG 132
Query: 464 -PGTWLTA-QQKKSKSEPGPLKKWWNSLRDNEKVFYPILAANLLVFGAWRIRALQPFMVK 637
WL + + +K + + KWWNSL D ++ I+AAN LVF WR+ +L M++
Sbjct: 133 IKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLHRTMIR 192
Query: 638 YFCSNPSGGAVCLPMVL---SHSAIIH 709
YF SNP+ +C PM+L SH ++ H
Sbjct: 193 YFTSNPASKVLCSPMLLSTFSHFSLFH 219
Score = 35.1 bits (77), Expect = 1.9
Identities = 14/19 (73%), Positives = 17/19 (89%)
Frame = +1
Query: 691 TFSHYSPLHLAANMYVLYS 747
TFSH+S H+AANMYVL+S
Sbjct: 211 TFSHFSLFHMAANMYVLWS 229
>UniRef50_Q9H300-2 Cluster: Isoform 2 of Q9H300 ; n=10;
Eutheria|Rep: Isoform 2 of Q9H300 - Homo sapiens (Human)
Length = 329
Score = 92.3 bits (219), Expect = 1e-17
Identities = 46/131 (35%), Positives = 71/131 (54%), Gaps = 2/131 (1%)
Frame = +2
Query: 284 RQALKPDPLENLHIETGPLHAKGLVKPLIFTVGVSAASLLGCVIWEYENLRVHASSLLRR 463
R AL P P+E P + L+KPL FTVG + + IW+YE+L+ S
Sbjct: 76 RSALIP-PVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDG 134
Query: 464 -PGTWLTAQQKKSKSE-PGPLKKWWNSLRDNEKVFYPILAANLLVFGAWRIRALQPFMVK 637
WL + + + + + + KWWN+L D ++ I+AAN+LVF WR+ +LQ M++
Sbjct: 135 IKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIR 194
Query: 638 YFCSNPSGGAV 670
YF SNP+ +
Sbjct: 195 YFTSNPASSVI 205
>UniRef50_UPI00015B5442 Cluster: PREDICTED: similar to conserved
hypothetical protein; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to conserved hypothetical protein -
Nasonia vitripennis
Length = 341
Score = 89.4 bits (212), Expect = 8e-17
Identities = 47/140 (33%), Positives = 74/140 (52%), Gaps = 1/140 (0%)
Frame = +2
Query: 305 PLENLHIE-TGPLHAKGLVKPLIFTVGVSAASLLGCVIWEYENLRVHASSLLRRPGTWLT 481
P N+ ++ +GP + + K +IF S A+ +G I EYE +R + + +
Sbjct: 53 PFANVEVQHSGPTNGSKIWKGIIFATAFSGATYVGATILEYERIRANTFKGYKN---FYW 109
Query: 482 AQQKKSKSEPGPLKKWWNSLRDNEKVFYPILAANLLVFGAWRIRALQPFMVKYFCSNPSG 661
+ + + WW++L + E+++Y I AN+LVF AWRI QP M+KYF +NP+
Sbjct: 110 SSKATVIGWRAQTRDWWSNLSEGERMWYFICFANVLVFLAWRIPTWQPIMLKYFSTNPAS 169
Query: 662 GAVCLPMVLSHSAIIHHCTW 721
CLPMVL S H+ W
Sbjct: 170 SVTCLPMVL--SMFSHYNLW 187
Score = 37.1 bits (82), Expect = 0.48
Identities = 17/25 (68%), Positives = 20/25 (80%)
Frame = +1
Query: 694 FSHYSPLHLAANMYVLYSXXPAALS 768
FSHY+ HLAANMYVL+S AA+S
Sbjct: 181 FSHYNLWHLAANMYVLHSFSGAAVS 205
>UniRef50_Q4SB14 Cluster: Chromosome undetermined SCAF14677, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF14677, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 352
Score = 81.4 bits (192), Expect = 2e-14
Identities = 50/144 (34%), Positives = 74/144 (51%), Gaps = 25/144 (17%)
Frame = +2
Query: 353 LVKPLIFTVGVSAAS----------LLGC----------VIWEYENLRVHASSLLRR-PG 469
L++PL+FTVGV S L C IW+YE+L+ S
Sbjct: 57 LLRPLVFTVGVRCCSPRTAAHVPQKLTPCQFTGSAFGSAAIWQYESLKSRVQSYFDEVQA 116
Query: 470 TWLTAQQKKSKSEPG-PLKKWWNSLRDNEKVFYPILAANLLVFGAWRIRALQPFMVKYFC 646
WL + + + + + +WW SL + ++ ILAAN LVF WR+ ALQP M++YF
Sbjct: 117 DWLEKLRPQKRGDVRREINQWWLSLTEGQRTVTGILAANALVFLCWRVPALQPSMIRYFT 176
Query: 647 SNPSGGAVCLPMVL---SHSAIIH 709
SNP+ ++C PM+L SH + +H
Sbjct: 177 SNPASKSLCTPMILSSFSHFSFLH 200
Score = 37.5 bits (83), Expect = 0.36
Identities = 16/26 (61%), Positives = 22/26 (84%)
Frame = +1
Query: 691 TFSHYSPLHLAANMYVLYSXXPAALS 768
+FSH+S LH+AANMYVL+S +A+S
Sbjct: 192 SFSHFSFLHMAANMYVLWSFSTSAVS 217
>UniRef50_Q8MQY3 Cluster: RH66343p; n=4; Diptera|Rep: RH66343p -
Drosophila melanogaster (Fruit fly)
Length = 380
Score = 79.4 bits (187), Expect = 9e-14
Identities = 49/148 (33%), Positives = 70/148 (47%), Gaps = 6/148 (4%)
Frame = +2
Query: 266 NSKRGSRQALKPDPLENLHIETG-PLHAKGLVKPLIFTVGVSAASLLGCVIWEYENLR-- 436
+S R LKP E E P+ ++K + FT + G I EYEN R
Sbjct: 73 HSNRKQSSNLKPTTGEPAAAEQNTPVPVNNVIKAVAFTGAFTVGCFAGATILEYENTRSL 132
Query: 437 VHASSLLRRPGTWLT---AQQKKSKSEPGPLKKWWNSLRDNEKVFYPILAANLLVFGAWR 607
+ + R G W + A + +++ W+SL +K+F PIL NL+ F WR
Sbjct: 133 ILEKARQARFGWWQSRSLADRDYWTQIKQDIRRHWDSLTPGDKMFAPILLCNLVAFAMWR 192
Query: 608 IRALQPFMVKYFCSNPSGGAVCLPMVLS 691
+ AL+ M+ YF SNP+ VC PM LS
Sbjct: 193 VPALKSTMITYFTSNPAAKVVCWPMFLS 220
Score = 37.5 bits (83), Expect = 0.36
Identities = 16/24 (66%), Positives = 19/24 (79%)
Frame = +1
Query: 691 TFSHYSPLHLAANMYVLYSXXPAA 762
TFSHYS +HL ANMYV++S AA
Sbjct: 221 TFSHYSAMHLFANMYVMHSFANAA 244
>UniRef50_Q58EK4 Cluster: Presenilins-associated rhomboid-like
protein, mitochondrial precursor; n=2; Danio rerio|Rep:
Presenilins-associated rhomboid-like protein,
mitochondrial precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 383
Score = 69.3 bits (162), Expect = 1e-10
Identities = 53/167 (31%), Positives = 79/167 (47%), Gaps = 23/167 (13%)
Frame = +2
Query: 278 GSRQALKPDPLENLHIETGPLHAKGLVKPLIFTVGVSAASLLGCVIWEYENLRVHAS--- 448
G +A+ P P+ L P L +PL+FTVG + S I +YE+++
Sbjct: 60 GHNRAVPPKPVPPLP----PRRPHQLFRPLVFTVGFTGCSFGAAAILQYESVKSRVQLAI 115
Query: 449 ---------SLLRRPGT------W--LTAQQKKSKSEPGPLKKWWNSLRDNEKVFYPILA 577
+LL T W L+ QK+ + +W+ L + +K I+A
Sbjct: 116 EEAKEEKRDTLLEGHDTTYWHNWWNQLSNFQKQVILLISAVDDFWSGLSEGQKTVTGIIA 175
Query: 578 ANLLVFGAWRIRALQPFMVKYFCSNPSGGAVCLPMVL---SHSAIIH 709
N +V WR+ A+Q F+VKYF SNP+ CLPMVL SH ++IH
Sbjct: 176 LNTVVLCCWRVPAMQRFLVKYFTSNPASKTRCLPMVLSSFSHYSVIH 222
>UniRef50_UPI000155573E Cluster: PREDICTED: hypothetical protein,
partial; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
hypothetical protein, partial - Ornithorhynchus anatinus
Length = 175
Score = 48.4 bits (110), Expect = 2e-04
Identities = 24/56 (42%), Positives = 31/56 (55%)
Frame = +2
Query: 284 RQALKPDPLENLHIETGPLHAKGLVKPLIFTVGVSAASLLGCVIWEYENLRVHASS 451
R AL P P+E T P K LVKP IFTVG + + IW+YE+L++ S
Sbjct: 97 RSALTP-PVEETVFYTSPCSLKTLVKPFIFTVGFTGCAFGSAAIWQYESLKLRVQS 151
>UniRef50_Q8I2Y1 Cluster: Putative uncharacterized protein PFI0840w;
n=5; Plasmodium|Rep: Putative uncharacterized protein
PFI0840w - Plasmodium falciparum (isolate 3D7)
Length = 324
Score = 35.1 bits (77), Expect = 1.9
Identities = 15/54 (27%), Positives = 28/54 (51%)
Frame = -3
Query: 545 PVVSSTIFSMDQALIYFFFVVQSATFLVFVVVKKREPVDSHIPILHSLVNWLLR 384
P S I+ ++I+F+F+ F +F+V+K PVDS + +N+ +
Sbjct: 262 PDKKSNIYLFSLSIIFFWFITTLVLFTLFIVIKINTPVDSSFIMNEDRLNFFFK 315
>UniRef50_Q4P592 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 484
Score = 33.9 bits (74), Expect = 4.5
Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 8/66 (12%)
Frame = +2
Query: 539 LRDNEKVFYPILAANLLVFGAWRIR------ALQPFMVKYFCSNPSGGAV--CLPMVLSH 694
L +++V P++A N LVFG W + A+ +M F PS + L V SH
Sbjct: 231 LLPSQQVVVPVVAINTLVFGLWTVASARRGGAMWRWMTTNFVHRPSANRMRTMLTSVFSH 290
Query: 695 SAIIHH 712
++H+
Sbjct: 291 QTLLHY 296
>UniRef50_A5E2I4 Cluster: Predicted protein; n=1; Lodderomyces
elongisporus NRRL YB-4239|Rep: Predicted protein -
Lodderomyces elongisporus (Yeast) (Saccharomyces
elongisporus)
Length = 548
Score = 33.5 bits (73), Expect = 5.9
Identities = 14/29 (48%), Positives = 21/29 (72%)
Frame = +2
Query: 233 KNGRLIRNSFHNSKRGSRQALKPDPLENL 319
++G+LIRN N + +RQ LKPDP+ +L
Sbjct: 160 RSGQLIRNKLLNIHQTTRQQLKPDPIPSL 188
>UniRef50_A6PV62 Cluster: Putative glycosyl hydrolase precursor;
n=1; Victivallis vadensis ATCC BAA-548|Rep: Putative
glycosyl hydrolase precursor - Victivallis vadensis ATCC
BAA-548
Length = 203
Score = 33.1 bits (72), Expect = 7.8
Identities = 16/54 (29%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Frame = +2
Query: 380 GVSAASLLGCVIWEYENLRVHASSLLRRPGTWLTAQQKKSKSEPGPLKKW--WN 535
G+S +L WE ++ R A L + PG W + ++ G +K W WN
Sbjct: 88 GISLLPILSGYDWEIQSCRPDAVPLYKHPGEWRNFVRAAAEHYKGRIKVWEIWN 141
>UniRef50_Q22WI6 Cluster: Rhomboid family protein; n=1; Tetrahymena
thermophila SB210|Rep: Rhomboid family protein -
Tetrahymena thermophila SB210
Length = 239
Score = 33.1 bits (72), Expect = 7.8
Identities = 14/28 (50%), Positives = 19/28 (67%)
Frame = +2
Query: 542 RDNEKVFYPILAANLLVFGAWRIRALQP 625
R N V Y +L ANLLVFG ++ R ++P
Sbjct: 49 RMNNPVTYSLLGANLLVFGLYQFRVIKP 76
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 738,915,375
Number of Sequences: 1657284
Number of extensions: 15186444
Number of successful extensions: 36114
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 35003
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 36103
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 64204279620
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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