Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmnc11a11
(687 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P04818 Cluster: Thymidylate synthase; n=129; root|Rep: ... 232 5e-60
UniRef50_Q2TA32 Cluster: Thymidylate synthase; n=4; cellular org... 231 9e-60
UniRef50_Q4PBV6 Cluster: Thymidylate synthase; n=1; Ustilago may... 230 2e-59
UniRef50_Q9UTI7 Cluster: Thymidylate synthase; n=3; Eukaryota|Re... 227 3e-58
UniRef50_O96650 Cluster: Thymidylate synthase; n=14; root|Rep: T... 226 3e-58
UniRef50_P07382 Cluster: Bifunctional dihydrofolate reductase-th... 219 5e-56
UniRef50_P12461 Cluster: Thymidylate synthase; n=14; Ascomycota|... 216 4e-55
UniRef50_Q4A320 Cluster: Bifunctional dihydrofolate reductase-th... 212 8e-54
UniRef50_Q27828 Cluster: Bifunctional dihydrofolate reductase-th... 209 4e-53
UniRef50_Q4U9G5 Cluster: Bifunctional dihydrofolate reductase/th... 206 5e-52
UniRef50_Q07422 Cluster: Bifunctional dihydrofolate reductase-th... 205 7e-52
UniRef50_Q27713 Cluster: Bifunctional dihydrofolate reductase-th... 204 2e-51
UniRef50_Q8MVZ9 Cluster: Bifunctional dihydrofolate reductase-th... 194 1e-48
UniRef50_Q5CPQ4 Cluster: Dihydrofolate reductase-thymidylate syn... 183 4e-45
UniRef50_Q8WYK3 Cluster: Thymidylate synthase; n=4; Eutheria|Rep... 179 5e-44
UniRef50_Q8MVZ8 Cluster: Bifunctional dihydrofolate reductase-th... 172 8e-42
UniRef50_Q8MVZ5 Cluster: Bifunctional dihydrofolate reductase-th... 163 4e-39
UniRef50_A3QU09 Cluster: Thymidylate synthase; n=1; Oryctes rhin... 162 8e-39
UniRef50_Q5UQG3 Cluster: Bifunctional dihydrofolate reductase-th... 162 8e-39
UniRef50_Q0INI0 Cluster: Os12g0446900 protein; n=11; cellular or... 159 4e-38
UniRef50_Q8MVZ6 Cluster: Bifunctional dihydrofolate reductase-th... 159 4e-38
UniRef50_Q8MW00 Cluster: Bifunctional dihydrofolate reductase-th... 151 2e-35
UniRef50_Q9Z671 Cluster: Thymidylate synthase; n=9; Alphaproteob... 126 5e-28
UniRef50_O33380 Cluster: Thymidylate synthase; n=116; cellular o... 117 3e-25
UniRef50_Q8G3T9 Cluster: Thymidylate synthase; n=287; root|Rep: ... 113 3e-24
UniRef50_Q0FG99 Cluster: Thymidylate synthase; n=3; root|Rep: Th... 108 1e-22
UniRef50_Q6QGJ5 Cluster: Putative thymidylate synthase; n=1; Ent... 100 4e-20
UniRef50_P00471 Cluster: Thymidylate synthase; n=17; Viruses|Rep... 99 5e-20
UniRef50_Q2S5G7 Cluster: Thymidylate synthase; n=8; Bacteria|Rep... 98 2e-19
UniRef50_A5KSZ1 Cluster: Thymidylate synthase; n=1; candidate di... 96 6e-19
UniRef50_Q76YC2 Cluster: DTMP synthase; n=1; Aeromonas phage Aeh... 96 6e-19
UniRef50_Q67JQ1 Cluster: Thymidylate synthase; n=1; Symbiobacter... 91 2e-17
UniRef50_P78029 Cluster: Thymidylate synthase; n=20; Bacteria|Re... 88 2e-16
UniRef50_Q8SCS7 Cluster: PHIKZ235; n=1; Pseudomonas phage phiKZ|... 85 1e-15
UniRef50_Q934U8 Cluster: Putative thymidylate synthase; n=1; Sal... 84 3e-15
UniRef50_Q81R23 Cluster: Thymidylate synthase; n=68; cellular or... 78 2e-13
UniRef50_Q6WIC0 Cluster: DTMP (Thymidylate) synthase; n=1; Vibri... 77 5e-13
UniRef50_Q7WP13 Cluster: Thymidylate synthase; n=43; Proteobacte... 76 7e-13
UniRef50_Q7Y427 Cluster: DTMP (Thymidylate) synthase; n=1; Enter... 72 2e-11
UniRef50_Q87SA0 Cluster: Thymidylate synthase; n=76; Proteobacte... 70 6e-11
UniRef50_P42326 Cluster: Thymidylate synthase A; n=9; root|Rep: ... 70 6e-11
UniRef50_Q6KGF1 Cluster: Putative thymidylate synthase; n=1; Ent... 69 8e-11
UniRef50_Q3IQP2 Cluster: Thymidylate synthase; n=4; Halobacteria... 62 9e-09
UniRef50_Q8VBA7 Cluster: Wsv068; n=2; Shrimp white spot syndrome... 61 3e-08
UniRef50_Q97EV3 Cluster: Thymidylate synthase; n=2; Clostridium|... 61 3e-08
UniRef50_Q8WYK4 Cluster: Thymidylate synthase; n=12; Deuterostom... 60 7e-08
UniRef50_A5Z9U8 Cluster: Thymidylate synthase; n=9; Bacteria|Rep... 45 0.002
UniRef50_Q5D6W4 Cluster: Thymidylate synthase-like protein; n=2;... 42 0.011
UniRef50_Q3F0X9 Cluster: Thymidylate synthase; n=1; Bacillus thu... 42 0.014
UniRef50_A2SMX7 Cluster: Putative thymidylate synthase; n=1; Met... 42 0.014
UniRef50_A0BWG9 Cluster: Chromosome undetermined scaffold_132, w... 37 0.40
UniRef50_A5BNR8 Cluster: Putative uncharacterized protein; n=1; ... 34 2.8
UniRef50_Q6IIS4 Cluster: HDC17231; n=1; Drosophila melanogaster|... 34 2.8
UniRef50_A7TG56 Cluster: Putative uncharacterized protein; n=1; ... 34 2.8
UniRef50_Q5KB76 Cluster: Putative uncharacterized protein; n=3; ... 34 3.7
UniRef50_Q5GYH6 Cluster: Putative uncharacterized protein; n=6; ... 33 4.9
UniRef50_A1ZKR9 Cluster: Putative uncharacterized protein; n=1; ... 33 8.6
UniRef50_Q8LLN8 Cluster: OAJNBa0031O09.10; n=1; Oryza sativa (ja... 33 8.6
UniRef50_A5DAN5 Cluster: Putative uncharacterized protein; n=1; ... 33 8.6
>UniRef50_P04818 Cluster: Thymidylate synthase; n=129; root|Rep:
Thymidylate synthase - Homo sapiens (Human)
Length = 313
Score = 232 bits (568), Expect = 5e-60
Identities = 104/157 (66%), Positives = 128/157 (81%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
H E QYL I I++ G ++ DRTG GTLS+FG RYSL + PLLTTKRVF +GV+E
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDE-FPLLTTKRVFWKGVLE 86
Query: 391 ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKY 570
ELLW I GST++K L++KGV IWDANGSR+FLD+LGF+ REEGDLGPVYGFQWRH GA+Y
Sbjct: 87 ELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEY 146
Query: 571 IDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
D ++DY+GQG+DQLQ VID+IK NP DRR+++CAWN
Sbjct: 147 RDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWN 183
>UniRef50_Q2TA32 Cluster: Thymidylate synthase; n=4; cellular
organisms|Rep: Thymidylate synthase - Bos taurus
(Bovine)
Length = 354
Score = 231 bits (566), Expect = 9e-60
Identities = 103/157 (65%), Positives = 127/157 (80%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
H E QYL I+ I++ G +R DRTG GTLS+FG RY+L + PLLTTKRVF +GV+E
Sbjct: 31 HGELQYLGQIEHILRCGFRRDDRTGTGTLSVFGMQARYNLRDE-FPLLTTKRVFWKGVLE 89
Query: 391 ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKY 570
ELLW I GST++K L++KGV IWDANGSR+FLD LGF+DR EGDLGPVYGFQWRH GA+Y
Sbjct: 90 ELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDGLGFSDRAEGDLGPVYGFQWRHFGAEY 149
Query: 571 IDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
D ++Y+GQG+DQLQ VID+IK NP DRR+++CAWN
Sbjct: 150 KDMDSEYSGQGVDQLQKVIDTIKTNPNDRRIILCAWN 186
>UniRef50_Q4PBV6 Cluster: Thymidylate synthase; n=1; Ustilago
maydis|Rep: Thymidylate synthase - Ustilago maydis (Smut
fungus)
Length = 554
Score = 230 bits (563), Expect = 2e-59
Identities = 102/159 (64%), Positives = 121/159 (76%), Gaps = 2/159 (1%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQ--RYSLHNNTLPLLTTKRVFTRGV 384
H+E QYL+L+ ++I +G+ R DRTG GTL++F R+ L N TLPLLTTKRVF RGV
Sbjct: 256 HEESQYLELVQRVISTGESRPDRTGTGTLALFAPQPSLRFDLTNGTLPLLTTKRVFFRGV 315
Query: 385 IEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGA 564
+EELLW + G TD+K L K VHIWD NGSR FLD+ G + R EGDLGPVYGFQWRH GA
Sbjct: 316 LEELLWFVGGKTDAKLLTEKSVHIWDGNGSRAFLDSRGLSHRREGDLGPVYGFQWRHFGA 375
Query: 565 KYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
Y DC TDY GQG+DQL SVID I+NNP DRR+L+ AWN
Sbjct: 376 TYKDCDTDYAGQGVDQLASVIDKIRNNPTDRRILLSAWN 414
>UniRef50_Q9UTI7 Cluster: Thymidylate synthase; n=3; Eukaryota|Rep:
Thymidylate synthase - Schizosaccharomyces pombe
(Fission yeast)
Length = 625
Score = 227 bits (554), Expect = 3e-58
Identities = 100/162 (61%), Positives = 125/162 (77%), Gaps = 1/162 (0%)
Frame = +1
Query: 199 EIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQ-RYSLHNNTLPLLTTKRVFT 375
E ++ +E QYL LI I+++G R DRTG GT S+F Q R+SL NNTLPLLTTKRVF
Sbjct: 324 EYRNTEEEQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFL 383
Query: 376 RGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRH 555
RGV+EELLW I G T++ L+ KG+HIWD NGSR FLD+ G TDR+ GDLGP+YGFQWRH
Sbjct: 384 RGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRH 443
Query: 556 SGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
GA+Y+DC TDYT +G+DQL VI ++K NP DRR+++ AWN
Sbjct: 444 FGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWN 485
>UniRef50_O96650 Cluster: Thymidylate synthase; n=14; root|Rep:
Thymidylate synthase - Ascaris suum (Pig roundworm)
(Ascaris lumbricoides)
Length = 294
Score = 226 bits (553), Expect = 3e-58
Identities = 101/158 (63%), Positives = 120/158 (75%)
Frame = +1
Query: 208 SHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVI 387
+ DE +YL+ I II GDK +DRTGVGTLS+FG YSL N +PLLTTKRV+ +GV+
Sbjct: 7 NEDERKYLRQIKHIIDEGDKVIDRTGVGTLSLFGLHSTYSLRNGVIPLLTTKRVYWKGVV 66
Query: 388 EELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAK 567
EELLW I G TD+K L+AKGV IWDANGSR FLD+ GF DR EGDLGP+YGFQWRH GA+
Sbjct: 67 EELLWFIKGDTDAKRLSAKGVKIWDANGSREFLDSQGFKDRPEGDLGPIYGFQWRHFGAE 126
Query: 568 YIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
Y DY GQG+DQL VI+ IKNNP RR+++ AWN
Sbjct: 127 YHGTDADYKGQGVDQLADVIEQIKNNPNSRRIILNAWN 164
>UniRef50_P07382 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=28; Trypanosomatidae|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Leishmania major
Length = 520
Score = 219 bits (535), Expect = 5e-56
Identities = 94/159 (59%), Positives = 125/159 (78%)
Frame = +1
Query: 205 KSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGV 384
++H+E QYL+LID+I+K+G + DRTGVGT+S+FGA R+SL +N LPLLTTKRVF RGV
Sbjct: 230 RNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGV 289
Query: 385 IEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGA 564
EELLW + G T ++ LA K +HIWD NGSR FLD+ G T+ +E DLGPVYGFQWRH GA
Sbjct: 290 CEELLWFLRGETSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGA 349
Query: 565 KYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
Y + +Y G+G+DQ++ ++++IK NP DRR+L+ AWN
Sbjct: 350 DYKGFEANYDGEGVDQIKLIVETIKTNPNDRRLLVTAWN 388
>UniRef50_P12461 Cluster: Thymidylate synthase; n=14;
Ascomycota|Rep: Thymidylate synthase - Candida albicans
(Yeast)
Length = 315
Score = 216 bits (528), Expect = 4e-55
Identities = 97/156 (62%), Positives = 117/156 (75%), Gaps = 1/156 (0%)
Frame = +1
Query: 217 EYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQ-RYSLHNNTLPLLTTKRVFTRGVIEE 393
E YL L +II G+ R DRTG GT S+F Q R+ L N+T PLLTTK+VF++G+I E
Sbjct: 9 EQAYLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHE 68
Query: 394 LLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYI 573
LLW ++GSTD+K L+ KGV IW+ NGSR FLD LG T R EGDLGPVYGFQWRH GA+Y
Sbjct: 69 LLWFVAGSTDAKILSEKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYK 128
Query: 574 DCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
DC +DYTGQG DQLQ VI +K NP DRR+++ AWN
Sbjct: 129 DCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAWN 164
>UniRef50_Q4A320 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Emiliania huxleyi
virus 86|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Emiliania huxleyi virus
86
Length = 480
Score = 212 bits (517), Expect = 8e-54
Identities = 93/157 (59%), Positives = 118/157 (75%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
H+EYQYL+LI ++++ G+ R DRTG GT+S+FG R++L + PLLTTKR + +G++E
Sbjct: 195 HEEYQYLQLISKVLEHGEYRSDRTGTGTVSLFGETMRFNLSTH-FPLLTTKRTYWKGIVE 253
Query: 391 ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKY 570
ELLW I GST++ LAAK V IWD NGSR+FLD++G D EEGDLGPVYGFQWRH GA Y
Sbjct: 254 ELLWFIRGSTNANELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADY 313
Query: 571 IDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
Y QG DQLQ+VID IKNNP RR+++ AWN
Sbjct: 314 KTMHDSYDSQGTDQLQNVIDQIKNNPTSRRIIMSAWN 350
>UniRef50_Q27828 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=15; Paramecium|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Paramecium tetraurelia
Length = 462
Score = 209 bits (511), Expect = 4e-53
Identities = 92/167 (55%), Positives = 121/167 (72%)
Frame = +1
Query: 181 THNNDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTT 360
+H + H E QYL +I +I+K G + DRTGVGT+SIFG R++L + PLLTT
Sbjct: 168 SHEQSYIDEEHQENQYLDMITKIMKEGVSKDDRTGVGTMSIFGQTMRFNLAQS-FPLLTT 226
Query: 361 KRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYG 540
K+VF RGV+EELLW + G+T+ K L KGV IW+ NG+R +LD +G R+E DLGPVYG
Sbjct: 227 KKVFFRGVVEELLWFLRGNTNGKLLLDKGVKIWEGNGTREYLDTIGLQHRQEHDLGPVYG 286
Query: 541 FQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
FQWRH GAKY DCQTDY+ QG+DQ++ +I +KNNP RR+++ AWN
Sbjct: 287 FQWRHFGAKYKDCQTDYSNQGVDQVKEIIQLLKNNPDSRRIILSAWN 333
>UniRef50_Q4U9G5 Cluster: Bifunctional dihydrofolate
reductase/thymidilate synthase, putative; n=4;
Piroplasmida|Rep: Bifunctional dihydrofolate
reductase/thymidilate synthase, putative - Theileria
annulata
Length = 523
Score = 206 bits (502), Expect = 5e-52
Identities = 91/162 (56%), Positives = 120/162 (74%)
Frame = +1
Query: 196 VEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFT 375
++++ E QYL+++ I+ +G + +RTGV ++ FG R+ L + + PLLTTK+VF
Sbjct: 233 LKVRYSQELQYLEILADILNNGYHKKNRTGVDCIAKFGYQMRFDL-SQSFPLLTTKKVFL 291
Query: 376 RGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRH 555
RG+IEEL+W I GST+ L K V IW+ NG+R+FLDNLGF DREE DLGPVYGFQWRH
Sbjct: 292 RGIIEELIWFIRGSTNGNELLKKNVRIWELNGARSFLDNLGFYDREEQDLGPVYGFQWRH 351
Query: 556 SGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
GAKYID DYT QGIDQL VI+ IKNNP +RR+++C+WN
Sbjct: 352 FGAKYIDMHADYTDQGIDQLSLVIERIKNNPDNRRLIVCSWN 393
>UniRef50_Q07422 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=1; Toxoplasma gondii|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Toxoplasma gondii
Length = 610
Score = 205 bits (501), Expect = 7e-52
Identities = 97/177 (54%), Positives = 120/177 (67%)
Frame = +1
Query: 151 RKLERKKYIMTHNNDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSL 330
RK +K ++ V + H+E+QYL LI II +G DRTGVG +S FG RYSL
Sbjct: 302 RKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSL 361
Query: 331 HNNTLPLLTTKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDR 510
+ PLLTTKRVF +GV+EELLW I G T++ L+ KGV IWD N +R FLD+ R
Sbjct: 362 -DQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHR 420
Query: 511 EEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
E GD+GP YGFQWRH GA Y D TDYTGQG+DQL++VI ++ NP DRRML+ AWN
Sbjct: 421 EVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWN 477
>UniRef50_Q27713 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=49; Plasmodium|Rep:
Bifunctional dihydrofolate reductase-thymidylate
synthase (DHFR-TS) [Includes: Dihydrofolate reductase
(EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] -
Plasmodium berghei (strain Anka)
Length = 587
Score = 204 bits (498), Expect = 2e-51
Identities = 93/188 (49%), Positives = 130/188 (69%)
Frame = +1
Query: 118 FTYHRNRKP*FRKLERKKYIMTHNNDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTL 297
F++++N++ + E +N+ ++ K+H EYQYL +I II G+K+ DRTGVG L
Sbjct: 272 FSFNKNKENIKKNSEHAHNFKIYNS-IKYKNHPEYQYLNIIYDIIMHGNKQDDRTGVGVL 330
Query: 298 SIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSR 477
S FG M +++L N PLLTTK++F RG+IEELLW I G T+ L K V IW+ANG+R
Sbjct: 331 SKFGYMMKFNL-NEYFPLLTTKKLFIRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTR 389
Query: 478 NFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADR 657
FLDN RE DLGP+YGFQWRH GA+Y D +Y +G+DQL+++I+ IKN+P R
Sbjct: 390 EFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTDMHDNYKDKGVDQLKNIINLIKNDPTCR 449
Query: 658 RMLICAWN 681
R+++CAWN
Sbjct: 450 RIILCAWN 457
>UniRef50_Q8MVZ9 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Cercomonas
longicauda|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Cercomonas longicauda
Length = 314
Score = 194 bits (474), Expect = 1e-48
Identities = 86/165 (52%), Positives = 117/165 (70%), Gaps = 1/165 (0%)
Frame = +1
Query: 190 NDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRV 369
++V + +E +Y+ LI +I G+ R DRTGVG +FG M ++SL N +PLLT +++
Sbjct: 137 DNVGNNNKEESEYIDLIRRIRDQGEIRTDRTGVGIKCVFGNMMKFSLENGQIPLLTIRKI 196
Query: 370 FTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQW 549
F +GV+EELLWM+ G T S+ L KGV+IW ANGSR LD LG DRE GDLGP+YG+QW
Sbjct: 197 FWKGVVEELLWMLRGKTHSRDLEEKGVNIWRANGSREALDRLGMVDREVGDLGPIYGWQW 256
Query: 550 RHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNP-ADRRMLICAWN 681
RHSGA Y TDY+G G+DQ++ VI ++N P +RR+L C+WN
Sbjct: 257 RHSGAXYTTAHTDYSGFGVDQIKDVISQLQNQPQKNRRILFCSWN 301
>UniRef50_Q5CPQ4 Cluster: Dihydrofolate reductase-thymidylate
synthase; n=14; cellular organisms|Rep: Dihydrofolate
reductase-thymidylate synthase - Cryptosporidium parvum
Iowa II
Length = 531
Score = 183 bits (445), Expect = 4e-45
Identities = 78/161 (48%), Positives = 109/161 (67%)
Frame = +1
Query: 205 KSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGV 384
+ H E+QYL L+ +++++G R +RTG+ T SIFG M R+ + + PLLTTK+V R +
Sbjct: 243 REHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRES-FPLLTTKKVAIRSI 301
Query: 385 IEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGA 564
EEL+W I G T+ L K V+IW NGS+ +L+ +G REE DLGP+YGFQWRH
Sbjct: 302 FEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNG 361
Query: 565 KYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSS 687
+Y DYTG G+DQL +I+++KNNP DRR ++ AWN S
Sbjct: 362 EYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPS 402
>UniRef50_Q8WYK3 Cluster: Thymidylate synthase; n=4; Eutheria|Rep:
Thymidylate synthase - Homo sapiens (Human)
Length = 279
Score = 179 bits (436), Expect = 5e-44
Identities = 82/126 (65%), Positives = 100/126 (79%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
H E QYL I I++ G ++ DRTG GTLS+FG RYSL + PLLTTKRVF +GV+E
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDE-FPLLTTKRVFWKGVLE 86
Query: 391 ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKY 570
ELLW I GST++K L++KGV IWDANGSR+FLD+LGF+ REEGDLGPVYGFQWRH GA+Y
Sbjct: 87 ELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEY 146
Query: 571 IDCQTD 588
D ++D
Sbjct: 147 RDMESD 152
>UniRef50_Q8MVZ8 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Chlamydaster
sterni|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Chlamydaster sterni
Length = 260
Score = 172 bits (418), Expect = 8e-42
Identities = 78/125 (62%), Positives = 95/125 (76%)
Frame = +1
Query: 190 NDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRV 369
ND + + +E QYL L+D+II SG +R DRTG GTLSIFG R+S ++TLPLLTTK+V
Sbjct: 136 NDDTLVNAEEKQYLDLVDRIITSGTQRGDRTGTGTLSIFGTQMRFSPRDDTLPLLTTKKV 195
Query: 370 FTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQW 549
F RGV EE+LW + G TD++ L+AK +HIWD N SR FLD G + REEGDLGPVYGFQW
Sbjct: 196 FWRGVAEEMLWFMKGCTDARVLSAKKIHIWDDNASRKFLDENGLSHREEGDLGPVYGFQW 255
Query: 550 RHSGA 564
RH GA
Sbjct: 256 RHFGA 260
>UniRef50_Q8MVZ5 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Tetrahymena
sp.|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Tetrahymena sp
Length = 311
Score = 163 bits (396), Expect = 4e-39
Identities = 71/122 (58%), Positives = 87/122 (71%)
Frame = +1
Query: 199 EIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTR 378
+++SH+E+QYL L+ +++ +G R DRTG GTLSIFGAM R+ L + PLLTTK+ F R
Sbjct: 190 KLRSHEEFQYLDLVQRVVSTGVSRGDRTGTGTLSIFGAMMRFDLSSGAFPLLTTKKTFLR 249
Query: 379 GVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHS 558
G+ EEL W + G T LAAK VHIWDAN +R FLD G DR EGDLGPVYG QW H
Sbjct: 250 GIAEELFWFLKGDTSQTRLAAKDVHIWDANATRAFLDARGLPDRPEGDLGPVYGCQWSHF 309
Query: 559 GA 564
GA
Sbjct: 310 GA 311
>UniRef50_A3QU09 Cluster: Thymidylate synthase; n=1; Oryctes
rhinoceros virus|Rep: Thymidylate synthase - Oryctes
rhinoceros virus
Length = 321
Score = 162 bits (393), Expect = 8e-39
Identities = 73/153 (47%), Positives = 99/153 (64%), Gaps = 1/153 (0%)
Frame = +1
Query: 226 YLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWM 405
YL L+ ++K+ +RTG+ S FG R+ L N LPLLTTK + + ++ EL W
Sbjct: 32 YLSLVRTVLKAPSSP-NRTGIDARSSFGHQLRFDLRNGVLPLLTTKPMPFKTILRELFWF 90
Query: 406 ISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGD-LGPVYGFQWRHSGAKYIDCQ 582
+ G T+ K L + VHIW N SR +LD+ G D E + LGP+YGFQWRH GA Y+DC
Sbjct: 91 LRGETNQKILERQNVHIWKGNSSREYLDSRGLYDYTEYESLGPIYGFQWRHFGASYVDCN 150
Query: 583 TDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
TDYT +G+DQLQ VI +IK +P RR+++ AWN
Sbjct: 151 TDYTNKGVDQLQQVIRTIKEDPTSRRIIMSAWN 183
>UniRef50_Q5UQG3 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)]; n=1; Acanthamoeba polyphaga
mimivirus|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase (DHFR-TS) [Includes:
Dihydrofolate reductase (EC 1.5.1.3); Thymidylate
synthase (EC 2.1.1.45)] - Mimivirus
Length = 563
Score = 162 bits (393), Expect = 8e-39
Identities = 81/180 (45%), Positives = 112/180 (62%), Gaps = 3/180 (1%)
Frame = +1
Query: 157 LERKKY-IMTHNNDVEIKSHD--EYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYS 327
+ RK + + +N++ I S + E QY++L+ I++ G + R + T SIFG +Y
Sbjct: 249 ITRKVFDLFNSSNEISIPSEECPENQYIELVKTIMEKGIVKQTRNSI-TKSIFGYQLKYD 307
Query: 328 LHNNTLPLLTTKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTD 507
L P+ T KR + + + EEL+WMI G TD L KGVH+WD N S++FL
Sbjct: 308 LSKG-YPIQTIKRSYPKAIFEELMWMIRGQTDVSILQKKGVHVWDKNSSKDFLSKYNLP- 365
Query: 508 REEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSS 687
EEGD+GP YGFQ R+ GA+Y DC+T Y GQGIDQL I+SI+NNP DRR++I WN S
Sbjct: 366 YEEGDIGPGYGFQMRYWGAEYTDCKTSYQGQGIDQLNKCIESIQNNPHDRRIMINLWNCS 425
>UniRef50_Q0INI0 Cluster: Os12g0446900 protein; n=11; cellular
organisms|Rep: Os12g0446900 protein - Oryza sativa
subsp. japonica (Rice)
Length = 571
Score = 159 bits (387), Expect = 4e-38
Identities = 81/157 (51%), Positives = 99/157 (63%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
H+EYQYL L+ II++G K+ DRTG GT+S FG R++L N PLLTTKRVF RGV+E
Sbjct: 305 HEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKFGCQMRFNLRRN-FPLLTTKRVFWRGVLE 363
Query: 391 ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKY 570
ELLW ISGST++K L KG+HIWD N SR +LD +Y
Sbjct: 364 ELLWFISGSTNAKVLQEKGIHIWDGNASRQYLD-------------------------RY 398
Query: 571 IDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
D DY G+G DQL VID IKNNP DRR+++ AWN
Sbjct: 399 TDMHADYVGKGFDQLMDVIDKIKNNPDDRRIILSAWN 435
>UniRef50_Q8MVZ6 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Diplonema
ambulator|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Diplonema ambulator
Length = 255
Score = 159 bits (387), Expect = 4e-38
Identities = 76/132 (57%), Positives = 91/132 (68%)
Frame = +1
Query: 169 KYIMTHNNDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLP 348
K M H + V + +E QYL L+D IIK+G + DRTGVGT+S FGA R+SL + +P
Sbjct: 127 KMTMYHYSKV---NKEEQQYLDLVDDIIKNGFTKGDRTGVGTISKFGAQMRFSLRDGVIP 183
Query: 349 LLTTKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLG 528
LLTTKRVF +GV EEL W I G T+ K L KGVHIWD NG+R FLD+ G DR E DLG
Sbjct: 184 LLTTKRVFWKGVAEELFWFIKGCTNGKDLKDKGVHIWDGNGTRAFLDSRGLPDRAEDDLG 243
Query: 529 PVYGFQWRHSGA 564
P+YG QW H GA
Sbjct: 244 PIYGLQWSHFGA 255
>UniRef50_Q8MW00 Cluster: Bifunctional dihydrofolate
reductase-thymidylate synthase; n=1; Amastigomonas
debruynei|Rep: Bifunctional dihydrofolate
reductase-thymidylate synthase - Amastigomonas debruynei
Length = 259
Score = 151 bits (366), Expect = 2e-35
Identities = 70/116 (60%), Positives = 85/116 (73%)
Frame = +1
Query: 217 EYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEEL 396
E YL LI +++ G +R DRTGVGT S+FG + L + PLLTTKRVF RGV EEL
Sbjct: 145 ELGYLDLIRRVLADGFERDDRTGVGTFSLFGEKLEFDLGDG-FPLLTTKRVFWRGVAEEL 203
Query: 397 LWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGA 564
LW +SGST++ LAAKG+ IWD N SR +LD++G T+RE GDLGPVYGFQW H GA
Sbjct: 204 LWFVSGSTNANELAAKGIRIWDGNSSREYLDSIGLTEREVGDLGPVYGFQWSHFGA 259
>UniRef50_Q9Z671 Cluster: Thymidylate synthase; n=9;
Alphaproteobacteria|Rep: Thymidylate synthase -
Zymomonas mobilis
Length = 296
Score = 126 bits (304), Expect = 5e-28
Identities = 71/171 (41%), Positives = 99/171 (57%), Gaps = 16/171 (9%)
Frame = +1
Query: 217 EYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEEL 396
E+QYL+L+ I++ GD+R DRTGVGTLS+FGAM R+ L +P+LTTK+V R I E+
Sbjct: 3 EHQYLRLVSDILEKGDQRHDRTGVGTLSLFGAMMRFDLSKGRIPILTTKKVSYRLAIREM 62
Query: 397 LWMISGSTDSKALAAKGVHIW-DANGSRNFLDNLGFTDREE---------------GDLG 528
LW +SG T+ + L +GV IW D +R + ++E GDLG
Sbjct: 63 LWFLSGDTNIRPLVEQGVSIWSDWPLARYQAETGALLSKKEFEAKILADTEFAKKWGDLG 122
Query: 529 PVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
PVYG QWR GQ DQ+ ++I+++K+NP+ RRML WN
Sbjct: 123 PVYGRQWRRWQGS--------DGQVYDQIATLIETLKSNPSSRRMLFHGWN 165
>UniRef50_O33380 Cluster: Thymidylate synthase; n=116; cellular
organisms|Rep: Thymidylate synthase - Neisseria
gonorrhoeae
Length = 265
Score = 117 bits (281), Expect = 3e-25
Identities = 64/152 (42%), Positives = 86/152 (56%)
Frame = +1
Query: 226 YLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWM 405
YL L+ ++ +G + DRTG GTLS+FG R+ L PLLTTK++ R +I ELLW
Sbjct: 4 YLDLMRHVLDNGTDKSDRTGTGTLSVFGYQMRFDLGKG-FPLLTTKKLHLRSIIHELLWF 62
Query: 406 ISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQT 585
+ G T+ K L V IWD + D E GDLGPVYG+QWR A
Sbjct: 63 LKGDTNIKYLKDNNVSIWDDE----------WAD-ENGDLGPVYGYQWRSWPAP------ 105
Query: 586 DYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
G+ IDQ+ +V++ IK NP RR+++ AWN
Sbjct: 106 --DGRHIDQIANVVEQIKKNPDSRRLIVSAWN 135
>UniRef50_Q8G3T9 Cluster: Thymidylate synthase; n=287; root|Rep:
Thymidylate synthase - Bifidobacterium longum
Length = 266
Score = 113 bits (273), Expect = 3e-24
Identities = 64/152 (42%), Positives = 87/152 (57%)
Frame = +1
Query: 226 YLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWM 405
Y L+ +I+ G + DRTG GT+S+FG R+ L + PLLTTK VF +G+ ELLW
Sbjct: 3 YEDLVRKILTEGTLKSDRTGTGTISLFGQQMRFDL-SKYFPLLTTKTVFFKGLAYELLWF 61
Query: 406 ISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQT 585
+ GS++ L VHIWD + D E GDLGPVYG QWR A
Sbjct: 62 LKGSSNINWLLEHNVHIWD-----EWAD-------ENGDLGPVYGVQWRSWPAP----TP 105
Query: 586 DYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
+ + IDQ+ +V+D IK++P RRM++ AWN
Sbjct: 106 EDPNRTIDQISNVLDLIKHHPDSRRMIVSAWN 137
>UniRef50_Q0FG99 Cluster: Thymidylate synthase; n=3; root|Rep:
Thymidylate synthase - alpha proteobacterium HTCC2255
Length = 292
Score = 108 bits (260), Expect = 1e-22
Identities = 66/165 (40%), Positives = 92/165 (55%), Gaps = 12/165 (7%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
QYL ++ I+ +G++ DRTGVGTLS+FG R++L P +TTK++ R ++ ELLW
Sbjct: 3 QYLDALNYIMDNGEEVSDRTGVGTLSVFGYQIRFNLQEG-FPAVTTKKLAWRSIVGELLW 61
Query: 403 MISGSTDSKALA--------AKGVH---IWDANGSRNFLDNLGFTDRE-EGDLGPVYGFQ 546
+ GSTD + LA VH IW AN + LG+ + + +LGPVYG Q
Sbjct: 62 FLEGSTDERRLAELTFNKDRTDLVHKKTIWTANADAQGAE-LGYENNDLIKELGPVYGHQ 120
Query: 547 WRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
WRH D DQ+ +I+ IKNNP RRM++ AWN
Sbjct: 121 WRH-----FDGTDKDISLSTDQIIWLINEIKNNPDSRRMILSAWN 160
>UniRef50_Q6QGJ5 Cluster: Putative thymidylate synthase; n=1;
Enterobacteria phage T5|Rep: Putative thymidylate
synthase - Bacteriophage T5
Length = 279
Score = 100 bits (239), Expect = 4e-20
Identities = 60/157 (38%), Positives = 86/157 (54%), Gaps = 4/157 (2%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
QYLK++ +I G+ R DRTG GT+SIF + ++ L P +TTKR+ + V+ ELLW
Sbjct: 3 QYLKILTDVILLGEPRNDRTGTGTVSIFDSYAKFDLREG-FPAVTTKRLAWKSVVGELLW 61
Query: 403 MISGSTDSKALA----AKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKY 570
+SGST+ L + W + N+ D ++G+LGPVYG QWR+ G
Sbjct: 62 FLSGSTNLHDLRVFTFGRDEGQWTI-WTPNYEDQAISMGYDKGNLGPVYGKQWRNFG--- 117
Query: 571 IDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
G DQ+ +I+ +KNNP RR L+ AWN
Sbjct: 118 ----------GRDQILELIEGLKNNPHGRRHLVSAWN 144
>UniRef50_P00471 Cluster: Thymidylate synthase; n=17; Viruses|Rep:
Thymidylate synthase - Bacteriophage T4
Length = 286
Score = 99 bits (238), Expect = 5e-20
Identities = 61/160 (38%), Positives = 86/160 (53%), Gaps = 7/160 (4%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
QY LI I ++G + DRTG GT+++FG+ R+ L P +TTK++ + I EL+W
Sbjct: 3 QYQDLIKDIFENGYETDDRTGTGTIALFGSKLRWDLTKG-FPAVTTKKLAWKACIAELIW 61
Query: 403 MISGSTDSKALAA-------KGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSG 561
+SGST+ L +G +WD N N +LG+ G+LGP+YG QWR G
Sbjct: 62 FLSGSTNVNDLRLIQHDSLIQGKTVWDEN-YENQAKDLGY---HSGELGPIYGKQWRDFG 117
Query: 562 AKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
G+DQ+ VID IK P DRR ++ AWN
Sbjct: 118 -------------GVDQIIEVIDRIKKLPNDRRQIVSAWN 144
>UniRef50_Q2S5G7 Cluster: Thymidylate synthase; n=8; Bacteria|Rep:
Thymidylate synthase - Salinibacter ruber (strain DSM
13855)
Length = 355
Score = 98.3 bits (234), Expect = 2e-19
Identities = 62/171 (36%), Positives = 88/171 (51%), Gaps = 18/171 (10%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
QYL + I+ G + DRTG GT+ +FG R+ L PLLTTKRV+ RGV EELLW
Sbjct: 64 QYLDYLQDILDHGTRHEDRTGTGTIRVFGRQLRFDLTEG-FPLLTTKRVWMRGVTEELLW 122
Query: 403 MISGSTDSKALAAKGVHIWDANGSRNFLDNLG-------FTDR---------EEGDLGPV 534
+ G T+ ++L V IW + + D G F +R GDLGPV
Sbjct: 123 FLRGETNIQSLVQADVSIWTDWPLQRYRDETGDEISQEAFEERIATDDAFAERWGDLGPV 182
Query: 535 YGFQWRHSGAKYIDCQTDYTG-QG-IDQLQSVIDSIKNNPADRRMLICAWN 681
YG QWR D+ G +G +DQ++ ++ ++ P RR ++ AW+
Sbjct: 183 YGTQWR-----------DFEGPEGRVDQIERLVRGLRETPHSRRHVVSAWH 222
>UniRef50_A5KSZ1 Cluster: Thymidylate synthase; n=1; candidate
division TM7 genomosp. GTL1|Rep: Thymidylate synthase -
candidate division TM7 genomosp. GTL1
Length = 280
Score = 96.3 bits (229), Expect = 6e-19
Identities = 59/158 (37%), Positives = 80/158 (50%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
H EYQYL+L+ I+K G + R G +IFG R+ + PLLTTK++ + ++
Sbjct: 3 HPEYQYLQLMADILKDGRSKPSRGIHGLKAIFGYQIRFDMRQG-FPLLTTKKMPFKILLH 61
Query: 391 ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKY 570
EL W ISGS+ L +H WD GF DLG VYG QWRH
Sbjct: 62 ELFWFISGSSSVDYLHEHKIHYWD-----------GFLHEGSDDLGRVYGVQWRHW---- 106
Query: 571 IDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNS 684
+ D G DQLQ I+ IK NP + +++ AWN+
Sbjct: 107 --LRPD--GSQFDQLQWAIEQIKTNPNSKAIIVSAWNA 140
>UniRef50_Q76YC2 Cluster: DTMP synthase; n=1; Aeromonas phage
Aeh1|Rep: DTMP synthase - Aeromonas phage Aeh1
Length = 277
Score = 96.3 bits (229), Expect = 6e-19
Identities = 62/159 (38%), Positives = 89/159 (55%), Gaps = 7/159 (4%)
Frame = +1
Query: 226 YLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWM 405
YL +I+ ++G+ +DRTGVGT S+ G + R+ + + P +TTK + + V E LW
Sbjct: 4 YLDIINYTFENGEDEMDRTGVGTRSVLGQVFRHDMADG-FPAVTTKTLAWKAVRGECLWF 62
Query: 406 ISGSTDSKALAAK--GVH-----IWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGA 564
++G T+ + L A GV IWD N + + LG+TD G+LGPVYG QWR
Sbjct: 63 MNGFTNVEVLRAMTYGVGSSSKTIWDDNFNHQGVA-LGYTD---GELGPVYGKQWR---- 114
Query: 565 KYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
D+ G +DQL I+ IK NP RR ++CAWN
Sbjct: 115 -------DFNG--VDQLAKAIERIKTNPECRRNIVCAWN 144
>UniRef50_Q67JQ1 Cluster: Thymidylate synthase; n=1; Symbiobacterium
thermophilum|Rep: Thymidylate synthase - Symbiobacterium
thermophilum
Length = 283
Score = 91.1 bits (216), Expect = 2e-17
Identities = 58/165 (35%), Positives = 88/165 (53%), Gaps = 10/165 (6%)
Frame = +1
Query: 217 EYQYLKLIDQIIKSGDKRV-------DRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFT 375
E QYL+L +I+ ++ + +RTG+GT+ +FG M ++ P LTTK++F
Sbjct: 4 EIQYLELCREILAENEQEIAEGRWTPNRTGMGTVGVFGRMLKHDFKEG-FPALTTKKLFF 62
Query: 376 RGVIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWR- 552
V ELLW ++G TD + L +G HIWD + +RN G LGP+YG QWR
Sbjct: 63 NSVKAELLWFLAGRTDLEFLHERGCHIWDKDAARN-----------GGKLGPIYGKQWRA 111
Query: 553 HSGAKYIDCQT-DYTGQGIDQLQSV-IDSIKNNPADRRMLICAWN 681
GA D +T D I Q++ + D + +P RR+++ WN
Sbjct: 112 WEGA---DGRTYDQIAWVIQQIREIAADPERPHPNSRRLVVSPWN 153
>UniRef50_P78029 Cluster: Thymidylate synthase; n=20; Bacteria|Rep:
Thymidylate synthase - Mycoplasma pneumoniae
Length = 287
Score = 88.2 bits (209), Expect = 2e-16
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 17/170 (10%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
QYL L +++ G R +RT + +FG + + + PLLTTK+V + ++ ELLW
Sbjct: 3 QYLDLARYVLEHGKYRPNRTDTAGIGVFGYQMHFDISKH-FPLLTTKKVHWKSIVHELLW 61
Query: 403 MISGSTDSKALAAKGVHIWDA------------NG--SRNFLDNL---GFTDREEGDLGP 531
I G T+ K L V+IW+ NG + F++ + ++ G+LGP
Sbjct: 62 FIKGDTNIKYLVDNKVNIWNEWPYESFKKSPHFNGESQKEFIERIRQDAKFAQQFGNLGP 121
Query: 532 VYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
VYG QWR D+ G+DQL+ VI IK NP RR+++ +WN
Sbjct: 122 VYGKQWR-----------DF--NGVDQLKKVIAQIKVNPFSRRLIVSSWN 158
>UniRef50_Q8SCS7 Cluster: PHIKZ235; n=1; Pseudomonas phage
phiKZ|Rep: PHIKZ235 - Pseudomonas phage phiKZ
Length = 488
Score = 85.4 bits (202), Expect = 1e-15
Identities = 40/80 (50%), Positives = 51/80 (63%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
QYL I + + G + DRTG GT S+FG +RYSL NN LP++TTK++ VI EL W
Sbjct: 3 QYLNSIRLVKEHGVHKGDRTGTGTQSMFGQQERYSLRNNRLPVVTTKKIHLASVIHELFW 62
Query: 403 MISGSTDSKALAAKGVHIWD 462
M+SG T L A GV IW+
Sbjct: 63 MLSGDTKVDYLIANGVRIWN 82
Score = 40.3 bits (90), Expect = 0.043
Identities = 13/25 (52%), Positives = 20/25 (80%)
Frame = +1
Query: 604 IDQLQSVIDSIKNNPADRRMLICAW 678
IDQ+Q +ID ++ NP RR+++CAW
Sbjct: 261 IDQIQDIIDQLRTNPDSRRIIVCAW 285
>UniRef50_Q934U8 Cluster: Putative thymidylate synthase; n=1;
Salmonella typhi|Rep: Putative thymidylate synthase -
Salmonella typhi
Length = 371
Score = 84.2 bits (199), Expect = 3e-15
Identities = 61/178 (34%), Positives = 90/178 (50%), Gaps = 26/178 (14%)
Frame = +1
Query: 226 YLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWM 405
Y K+++ ++ SG DRTG GT S+ Y L ++PL++ K V + ++ EL W
Sbjct: 23 YAKVVETVLNSGVHAGDRTGTGTKSVSYVPSYYMLTGGSVPLISGKAVNLKPLLVELEWY 82
Query: 406 ISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRH-------SGA 564
+ G+ + + L GV IWDA + D E GDLGPVYG QWR S +
Sbjct: 83 LKGTGNIQFLKDNGVKIWDA-----------WAD-ENGDLGPVYGKQWRRWEDTRIVSHS 130
Query: 565 KY---IDC--QTDYTGQG--------------IDQLQSVIDSIKNNPADRRMLICAWN 681
+Y ID + Y +G IDQLQ ++ +++ NP DRR+L+ AWN
Sbjct: 131 EYLSKIDTFRERGYKVEGYLGVSEDRVVLSREIDQLQRIVHTLRTNPTDRRILLNAWN 188
>UniRef50_Q81R23 Cluster: Thymidylate synthase; n=68; cellular
organisms|Rep: Thymidylate synthase - Bacillus anthracis
Length = 318
Score = 77.8 bits (183), Expect = 2e-13
Identities = 40/106 (37%), Positives = 62/106 (58%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
H E +YL L +++ G K+ DRTG GT+S+FG R+ L + PLLTTKRV R V
Sbjct: 3 HAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDL-SKGFPLLTTKRVPFRLVAS 61
Query: 391 ELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLG 528
ELLW + G T+ + L +IW+ ++++++ +T + D G
Sbjct: 62 ELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMIDFG 107
Score = 46.4 bits (105), Expect = 7e-04
Identities = 26/69 (37%), Positives = 39/69 (56%)
Frame = +1
Query: 475 RNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPAD 654
+N L++ F+++ G LG VYG QWR G+ +DQL+ VI+ IK P
Sbjct: 129 KNVLEDDEFSNKY-GYLGDVYGKQWR--------AWKTTAGETLDQLKDVIEMIKKTPDS 179
Query: 655 RRMLICAWN 681
RR+++ AWN
Sbjct: 180 RRLIVSAWN 188
>UniRef50_Q6WIC0 Cluster: DTMP (Thymidylate) synthase; n=1; Vibrio
phage KVP40|Rep: DTMP (Thymidylate) synthase -
Bacteriophage KVP40
Length = 300
Score = 76.6 bits (180), Expect = 5e-13
Identities = 57/162 (35%), Positives = 81/162 (50%), Gaps = 10/162 (6%)
Frame = +1
Query: 226 YLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWM 405
YL+L +I+ GD +RTG T+S+ R+ L PLLTTK++ T+ + ELLW
Sbjct: 5 YLQLCTEILNEGDFLENRTGTNTVSVISRELRWDLSKG-FPLLTTKKMATKAIFGELLWF 63
Query: 406 ISGS---TDSK---ALAAKGVHIWDAN-GSRNFLDNLGFTDREEGDLGPVYGFQWRHSGA 564
+SGS +D + L+ + IW N N R E DLG VYG WR +
Sbjct: 64 LSGSGLISDLRKYTELSDEDFCIWQQNLDELNERAKKAGIVRNEDDLGYVYGKVWRKRLS 123
Query: 565 KYIDCQTDYTGQGIDQLQSVIDSIKNNP---ADRRMLICAWN 681
D + Q I QL I ++K +P A RRM++ AW+
Sbjct: 124 VTADKEVTEFDQ-IHQLLCDIAAVKEDPTQSAQRRMIVEAWD 164
>UniRef50_Q7WP13 Cluster: Thymidylate synthase; n=43;
Proteobacteria|Rep: Thymidylate synthase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 323
Score = 76.2 bits (179), Expect = 7e-13
Identities = 57/180 (31%), Positives = 84/180 (46%), Gaps = 27/180 (15%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
QYL L+ I+ G + +RTGV TLS+ GA R+ L P +TTK++ + I E++
Sbjct: 3 QYLDLVQSILDQGAWQENRTGVRTLSLPGAALRFDLQQG-FPAVTTKKLAFKSAIGEMVG 61
Query: 403 MISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDRE-EGDLGPVYGFQW---------- 549
+ + + A G +WD N + N L RE DLGPVYG QW
Sbjct: 62 FLRATRSAAQFRALGCKVWDQNANENE-QWLANPYREGPDDLGPVYGVQWRHWPAYKLLP 120
Query: 550 RHSGAKYIDC---------QTDYTG-------QGIDQLQSVIDSIKNNPADRRMLICAWN 681
R +G + D + G + +DQL+ +D+I +P DRR+L WN
Sbjct: 121 RSAGGQVADALARGYRQVAEVAENGAPHVLLYKAVDQLRQCLDTIHQSPGDRRILFHGWN 180
>UniRef50_Q7Y427 Cluster: DTMP (Thymidylate) synthase; n=1;
Enterobacteria phage RB49|Rep: DTMP (Thymidylate)
synthase - Enterobacteria phage RB49
Length = 410
Score = 71.7 bits (168), Expect = 2e-11
Identities = 37/71 (52%), Positives = 47/71 (66%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLW 402
+YLKL+ ++ +G R DRTGVGTLS FGA R L + PLLTTK++ T VI ELLW
Sbjct: 3 EYLKLLRDVLDNGWPREDRTGVGTLSKFGAEMRIDL-SKGFPLLTTKKMATASVIGELLW 61
Query: 403 MISGSTDSKAL 435
+ GS D + L
Sbjct: 62 FMEGSLDRRRL 72
Score = 43.2 bits (97), Expect = 0.006
Identities = 17/25 (68%), Positives = 22/25 (88%)
Frame = +1
Query: 607 DQLQSVIDSIKNNPADRRMLICAWN 681
DQLQ+VI+ IKNNP DRR++I +WN
Sbjct: 254 DQLQNVIEQIKNNPTDRRIIIDSWN 278
>UniRef50_Q87SA0 Cluster: Thymidylate synthase; n=76;
Proteobacteria|Rep: Thymidylate synthase - Vibrio
parahaemolyticus
Length = 283
Score = 69.7 bits (163), Expect = 6e-11
Identities = 51/156 (32%), Positives = 78/156 (50%), Gaps = 3/156 (1%)
Frame = +1
Query: 223 QYLKLIDQIIKSGD-KRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELL 399
QYL L +I+ G +RTG L++ A Y + NN PL+TT++ F + + ELL
Sbjct: 3 QYLDLCQRIVDQGVWVENERTGKRCLTVINADLTYDVANNQFPLVTTRKSFWKAAVAELL 62
Query: 400 WMISGSTDSKALAAKGVHIWDANGSRN--FLDNLGFTDREEGDLGPVYGFQWRHSGAKYI 573
I G +++ G WDAN + N +L+N + E D+G VYG Q R + AK
Sbjct: 63 GYIRGYDNAEDFRKLGTKTWDANANLNDAWLNNP--YRKGEDDMGRVYGVQGR-AWAK-- 117
Query: 574 DCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
G IDQL+ ++D + DR ++ +N
Sbjct: 118 -----PDGGHIDQLRKIVDDLTRGVDDRGEILNFYN 148
>UniRef50_P42326 Cluster: Thymidylate synthase A; n=9; root|Rep:
Thymidylate synthase A - Bacillus subtilis
Length = 279
Score = 69.7 bits (163), Expect = 6e-11
Identities = 47/137 (34%), Positives = 67/137 (48%), Gaps = 1/137 (0%)
Frame = +1
Query: 274 DRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWMIS-GSTDSKALAAKGV 450
D T TLS+ R+ N+ +P+LTTK+V + I+ELLW+ S D L GV
Sbjct: 34 DGTPAHTLSVISKQMRFD--NSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGV 91
Query: 451 HIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVID 630
HIWD +E+G +G YGFQ G K G+ +DQ+ ++
Sbjct: 92 HIWDQ------------WKQEDGTIGHAYGFQL---GKK----NRSLNGEKVDQVDYLLH 132
Query: 631 SIKNNPADRRMLICAWN 681
+KNNP+ RR + WN
Sbjct: 133 QLKNNPSSRRHITMLWN 149
>UniRef50_Q6KGF1 Cluster: Putative thymidylate synthase; n=1;
Enterobacteria phage Felix 01|Rep: Putative thymidylate
synthase - Enterobacteria phage Felix 01
Length = 299
Score = 69.3 bits (162), Expect = 8e-11
Identities = 52/170 (30%), Positives = 82/170 (48%), Gaps = 10/170 (5%)
Frame = +1
Query: 208 SHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQ-RYSLHNNTLPLLTTKRVFTRGV 384
S + Y +++ ++ G+ R RTG +S F Q R+ + PLLT+K+VFTR V
Sbjct: 2 SQADLSYKNILNHVLSVGELRTTRTG-DVISAFAPPQFRFDMRTG-FPLLTSKQVFTRQV 59
Query: 385 IEELLWMISGSTDSKALAAK--GVH------IWDANGSRNFLDNLGF-TDREEGDLGPVY 537
I E LW ++G L + G + IW + R N D E G +Y
Sbjct: 60 IGEALWFLNGENKLSELRYRTWGENDGERWTIWSDDFKRWLSSNYSSEQDWLEDAGGRIY 119
Query: 538 GFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWNSS 687
G QWR+ + G +DQL++++ +K + DR ML+ AWN++
Sbjct: 120 GVQWRNF--------EGHNGCVVDQLETLVTKMKGDITDRYMLVNAWNAA 161
>UniRef50_Q3IQP2 Cluster: Thymidylate synthase; n=4;
Halobacteriaceae|Rep: Thymidylate synthase -
Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
Length = 342
Score = 62.5 bits (145), Expect = 9e-09
Identities = 51/164 (31%), Positives = 74/164 (45%), Gaps = 11/164 (6%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFT---RGVIEE 393
QY L+ ++ G + +RTGV T++ F L PLLTTKR+ +I E
Sbjct: 3 QYHDLVSDVLAGGTHKPNRTGVDTIASFSHHYEVDLGAG-FPLLTTKRMDGYRWNSLIHE 61
Query: 394 LLWMISGSTDSKALAAKGVHIWDA-NGSRNFLDNL--GFTDREEGDLGPVY--GFQWRHS 558
LLW +SG + L + IWDA LD F R P G W
Sbjct: 62 LLWYLSGEEHIRTLREE-TKIWDAWADDEGHLDTAYGRFWRRFPVPDEPARLPGESWPDD 120
Query: 559 GAKYIDCQTDYTG---QGIDQLQSVIDSIKNNPADRRMLICAWN 681
++ +T G Q DQL V+D+++ NP RR+++ AW+
Sbjct: 121 SHRWTTTETTPDGTERQVFDQLAYVLDTLEENPHSRRLVVNAWH 164
>UniRef50_Q8VBA7 Cluster: Wsv068; n=2; Shrimp white spot syndrome
virus|Rep: Wsv068 - White spot syndrome virus (WSSV)
Length = 77
Score = 60.9 bits (141), Expect = 3e-08
Identities = 36/77 (46%), Positives = 43/77 (55%)
Frame = -2
Query: 455 MCTPLAANAFESVDPEIIHSSSSITPLVNTRLVVRSGSVLL*REYLCIAPNIERVPTPVL 276
MC AN+ SV P + H SSS TPL LVVR+G V RE L P ++RVP PVL
Sbjct: 1 MCIFFLANSLASVLPLMNHKSSSTTPLQKIFLVVRTGIVSSRRENLIWGPKMDRVPVPVL 60
Query: 275 STLLSPDFMIWSISFKY 225
S+ +P I FKY
Sbjct: 61 SSFFTPLSRISLTRFKY 77
>UniRef50_Q97EV3 Cluster: Thymidylate synthase; n=2;
Clostridium|Rep: Thymidylate synthase - Clostridium
acetobutylicum
Length = 263
Score = 60.9 bits (141), Expect = 3e-08
Identities = 48/159 (30%), Positives = 79/159 (49%), Gaps = 1/159 (0%)
Frame = +1
Query: 208 SHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVI 387
S + +YL +I+ I+++G +RTG+ T + + ++ L + P+LTTK V + +
Sbjct: 2 SKADEKYLDIIENILENGYYDNNRTGIETYKLPHQIMQFDL-SKEFPILTTKFVAFKTSV 60
Query: 388 EELLWMISG-STDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSGA 564
+ELLW+ S D + L + V IWD E+G +G YG+Q A
Sbjct: 61 KELLWIYKDQSNDVRKLQNENVTIWDE------------WMLEDGTIGKAYGYQ----VA 104
Query: 565 KYIDCQTDYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
K+ Q+ ++ID++K +P RRMLI WN
Sbjct: 105 KF------------KQIDNLIDTLKTDPQSRRMLISLWN 131
>UniRef50_Q8WYK4 Cluster: Thymidylate synthase; n=12;
Deuterostomia|Rep: Thymidylate synthase - Homo sapiens
(Human)
Length = 230
Score = 59.7 bits (138), Expect = 7e-08
Identities = 23/32 (71%), Positives = 29/32 (90%)
Frame = +1
Query: 586 DYTGQGIDQLQSVIDSIKNNPADRRMLICAWN 681
DY+GQG+DQLQ VID+IK NP DRR+++CAWN
Sbjct: 69 DYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWN 100
Score = 49.6 bits (113), Expect = 7e-05
Identities = 22/42 (52%), Positives = 28/42 (66%)
Frame = +1
Query: 211 HDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHN 336
H E QYL I I++ G ++ DRTG GTLS+FG RYSL +
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRD 69
>UniRef50_A5Z9U8 Cluster: Thymidylate synthase; n=9; Bacteria|Rep:
Thymidylate synthase - Eubacterium ventriosum ATCC 27560
Length = 282
Score = 45.2 bits (102), Expect = 0.002
Identities = 36/130 (27%), Positives = 61/130 (46%)
Frame = +1
Query: 292 TLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWMISGSTDSKALAAKGVHIWDANG 471
T+ FG + RY L P +T ++ + ++ELLW+ +++ + HIWDA
Sbjct: 39 TIKKFGVVNRYDLKKE-FPAITLRKTGFKNCLDELLWIWQKKSNN--VHDLNSHIWDA-- 93
Query: 472 SRNFLDNLGFTDREEGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSVIDSIKNNPA 651
+ D E G +G YG+Q G K+ Y +DQ+ V+ +K+NP
Sbjct: 94 ---------WAD-ETGSIGKAYGYQL---GIKH-----HYKEGDMDQVDRVLYDLKHNPY 135
Query: 652 DRRMLICAWN 681
RR++ +N
Sbjct: 136 SRRIMTNIYN 145
>UniRef50_Q5D6W4 Cluster: Thymidylate synthase-like protein; n=2;
Enterobacteriaceae|Rep: Thymidylate synthase-like
protein - Escherichia coli
Length = 105
Score = 42.3 bits (95), Expect = 0.011
Identities = 21/46 (45%), Positives = 30/46 (65%)
Frame = +1
Query: 226 YLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTK 363
Y L+ ++I +G VDRTGVGT+SI+GAM +++L P T K
Sbjct: 4 YKDLLREVIITGTDSVDRTGVGTVSIWGAMLKFNLQEG-FPATTCK 48
>UniRef50_Q3F0X9 Cluster: Thymidylate synthase; n=1; Bacillus
thuringiensis serovar israelensis ATCC 35646|Rep:
Thymidylate synthase - Bacillus thuringiensis serovar
israelensis ATCC 35646
Length = 286
Score = 41.9 bits (94), Expect = 0.014
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 3/139 (2%)
Frame = +1
Query: 274 DRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWMI-SGSTDSKALAAKGV 450
D + + T IFG + RY L + P TT+ + + + +E+ W+ S + + AK
Sbjct: 30 DGSPIATKRIFGVVNRYDL-SKEFPAPTTRPLPLKTIFDEVDWIYRKRSNNVNDMRAKIW 88
Query: 451 HIWDANGSR-NFLDNLGFTDRE-EGDLGPVYGFQWRHSGAKYIDCQTDYTGQGIDQLQSV 624
+ W +R F F E +G +G YG+Q Y D Q DY V
Sbjct: 89 NQWAFKKTRLRFSKTFPFVRLEKKGSIGEAYGYQVAKPIFGY-DNQMDY----------V 137
Query: 625 IDSIKNNPADRRMLICAWN 681
+ +K +P RR +I WN
Sbjct: 138 LGELKRDPFTRRAVIEMWN 156
>UniRef50_A2SMX7 Cluster: Putative thymidylate synthase; n=1;
Methylibium petroleiphilum PM1|Rep: Putative thymidylate
synthase - Methylibium petroleiphilum (strain PM1)
Length = 316
Score = 41.9 bits (94), Expect = 0.014
Identities = 41/176 (23%), Positives = 76/176 (43%), Gaps = 23/176 (13%)
Frame = +1
Query: 223 QYLKLIDQIIKSGDKRVD-RTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELL 399
Q+ ++ I+ G ++++ RTG L + G R+ + + P +TTK++F + EL
Sbjct: 3 QFHDMLQHILDHGSRQLNARTGEEVLFVPGYTLRFDMADG-FPAITTKQLFFKMAKGELF 61
Query: 400 WMISGSTDSKALAAKGVHIW--DANGSRNFLDNLGFTDREE-GDLGPVYGFQWRHSGAKY 570
G T + G +W +AN ++ +L N ++ G G + WR
Sbjct: 62 GFFRGFTSAAQFREIGCTVWNDNANKTKAWLANPYRQGEDDLGRFGYLQWTDWRDWREAT 121
Query: 571 IDCQTD-YTGQG------------------IDQLQSVIDSIKNNPADRRMLICAWN 681
Q D QG I+QL++ + ++ NP+DR +++ WN
Sbjct: 122 TPAQRDEMLAQGYEVRAHDAERGVWILRRSINQLETSLHAVMTNPSDRGIILSGWN 177
>UniRef50_A0BWG9 Cluster: Chromosome undetermined scaffold_132, whole
genome shotgun sequence; n=1; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_132, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 1004
Score = 37.1 bits (82), Expect = 0.40
Identities = 21/80 (26%), Positives = 40/80 (50%)
Frame = +1
Query: 157 LERKKYIMTHNNDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHN 336
+ R KYI HN + K + E ++L++ Q++ S K ++ T + Y +HN
Sbjct: 850 IRRLKYIQNHNIECVDKDYQEMEFLRMKLQVLLSLQKGLEDT-KEKFETVRQFKFYCVHN 908
Query: 337 NTLPLLTTKRVFTRGVIEEL 396
N +LT + F + +++L
Sbjct: 909 NVDQILTVQNEFYKVKLQQL 928
>UniRef50_A5BNR8 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 534
Score = 34.3 bits (75), Expect = 2.8
Identities = 20/69 (28%), Positives = 34/69 (49%)
Frame = +1
Query: 151 RKLERKKYIMTHNNDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSL 330
++L+RK Y+M E K+ L L++ K RV T +G ++F M+ YS
Sbjct: 200 KELQRKLYMMALKRKFEFKTTKSTTKLLLVECFDKECKWRVRATKLGISNMFQIMKYYST 259
Query: 331 HNNTLPLLT 357
H L +++
Sbjct: 260 HTCRLDMMS 268
>UniRef50_Q6IIS4 Cluster: HDC17231; n=1; Drosophila
melanogaster|Rep: HDC17231 - Drosophila melanogaster
(Fruit fly)
Length = 93
Score = 34.3 bits (75), Expect = 2.8
Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Frame = +1
Query: 442 KGVHIWDANGSRNFLD-NLGFTDREEGDLGPVYGFQWRHSGAKYI 573
KG H+W N +R F+ LGF D+ + P +GF W SG +Y+
Sbjct: 8 KGSHVWKDNATRMFIKFTLGFIDQ----IRPDFGFLWL-SGMRYV 47
>UniRef50_A7TG56 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 877
Score = 34.3 bits (75), Expect = 2.8
Identities = 27/75 (36%), Positives = 40/75 (53%), Gaps = 4/75 (5%)
Frame = +1
Query: 280 TGVGTLSIFGAMQ-RYSLHNNTLPLLTTKRVFTRG--VIEELLWMISGSTDSKALAAKGV 450
+G+G+ S +Q +LH T+P++ K T IEEL M G T+ +A+ A
Sbjct: 804 SGLGSSSQPDVVQGTNTLHTPTVPVIDRKLATTPKSLAIEELCGM--GFTEDEAVKALEK 861
Query: 451 HIWDANGSRNF-LDN 492
H WD + + NF LDN
Sbjct: 862 HNWDLDAATNFLLDN 876
>UniRef50_Q5KB76 Cluster: Putative uncharacterized protein; n=3;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 529
Score = 33.9 bits (74), Expect = 3.7
Identities = 14/44 (31%), Positives = 24/44 (54%)
Frame = +1
Query: 259 GDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIE 390
G ++ D+TG+GT++++G +H N LLT G+ E
Sbjct: 80 GIQQTDKTGLGTMNLYGVQADTGMHGNQYSLLTVVFYTAYGICE 123
>UniRef50_Q5GYH6 Cluster: Putative uncharacterized protein; n=6;
Xanthomonas|Rep: Putative uncharacterized protein -
Xanthomonas oryzae pv. oryzae
Length = 397
Score = 33.5 bits (73), Expect = 4.9
Identities = 20/55 (36%), Positives = 28/55 (50%)
Frame = +1
Query: 283 GVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRGVIEELLWMISGSTDSKALAAKG 447
G G SI GA++ SL LP R +GV LL++ +G + A+ AKG
Sbjct: 214 GAGVFSILGALRSGSLATVALPFSAFYRAMPQGVQWLLLYISAGPYNFGAILAKG 268
>UniRef50_A1ZKR9 Cluster: Putative uncharacterized protein; n=1;
Microscilla marina ATCC 23134|Rep: Putative
uncharacterized protein - Microscilla marina ATCC 23134
Length = 689
Score = 32.7 bits (71), Expect = 8.6
Identities = 12/34 (35%), Positives = 22/34 (64%)
Frame = +1
Query: 361 KRVFTRGVIEELLWMISGSTDSKALAAKGVHIWD 462
K+ F ++EELL+ S+D++ ++ K H+WD
Sbjct: 141 KKKFEDRILEELLYAFDDSSDAQRISVKLSHVWD 174
>UniRef50_Q8LLN8 Cluster: OAJNBa0031O09.10; n=1; Oryza sativa
(japonica cultivar-group)|Rep: OAJNBa0031O09.10 - Oryza
sativa subsp. japonica (Rice)
Length = 391
Score = 32.7 bits (71), Expect = 8.6
Identities = 20/64 (31%), Positives = 33/64 (51%)
Frame = +1
Query: 163 RKKYIMTHNNDVEIKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNT 342
R ++ +H N + E K DQ++ +G RV RTG L + +Q++ LH T
Sbjct: 241 RYQFTASHRNGPPVSRDPEALKAKYSDQLVFTGSIRV-RTGYEILRLTSYLQQH-LHRIT 298
Query: 343 LPLL 354
+P+L
Sbjct: 299 VPML 302
>UniRef50_A5DAN5 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 195
Score = 32.7 bits (71), Expect = 8.6
Identities = 27/105 (25%), Positives = 49/105 (46%), Gaps = 5/105 (4%)
Frame = +1
Query: 148 FRKLERKKYIMTHNNDVEI----KSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAM 315
F+ L ++ + ND+EI K+ D+Y LKL + I + DK V L I G+
Sbjct: 7 FKTLVDQEVTVELKNDIEIRGTLKTVDQYLNLKLDNVICLNEDKYPHMQSVKNLFIRGST 66
Query: 316 QRY-SLHNNTLPLLTTKRVFTRGVIEELLWMISGSTDSKALAAKG 447
RY + +NT+ + RG+ +++ +T+ + + G
Sbjct: 67 VRYVHMSSNTVDCTLLQDASRRGMYNFFALVVATNTNFRGYGSVG 111
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 631,461,572
Number of Sequences: 1657284
Number of extensions: 12261875
Number of successful extensions: 32434
Number of sequences better than 10.0: 59
Number of HSP's better than 10.0 without gapping: 31402
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 32357
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 53719013270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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