Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmmt5c07
(610 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
L07033-1|AAA92733.1| 325|Homo sapiens hydroxymethylglutaryl-CoA... 190 2e-48
CR456884-1|CAG33165.1| 325|Homo sapiens HMGCL protein. 190 2e-48
BT009792-1|AAP88794.1| 325|Homo sapiens 3-hydroxymethyl-3-methy... 190 2e-48
BC010570-1|AAH10570.1| 325|Homo sapiens 3-hydroxymethyl-3-methy... 190 2e-48
U49719-1|AAB19099.1| 305|Homo sapiens hydroxymethylglutaryl-CoA... 189 8e-48
AL031295-19|CAI23161.1| 300|Homo sapiens 3-hydroxymethyl-3-meth... 189 8e-48
BC024194-1|AAH24194.2| 340|Homo sapiens 3-hydroxymethyl-3-methy... 180 3e-45
AK127587-1|BAC87045.1| 297|Homo sapiens protein ( Homo sapiens ... 180 3e-45
AL590406-2|CAI40662.1| 241|Homo sapiens protein ( Human DNA seq... 116 9e-26
AL590406-1|CAI40661.1| 157|Homo sapiens protein ( Human DNA seq... 70 4e-21
AL590290-1|CAI39775.1| 157|Homo sapiens protein ( Human DNA seq... 70 4e-21
AL137605-1|CAB70838.1| 157|Homo sapiens hypothetical protein pr... 70 4e-21
AF131827-1|AAD20054.1| 191|Homo sapiens Unknown protein. 61 3e-09
>L07033-1|AAA92733.1| 325|Homo sapiens hydroxymethylglutaryl-CoA
lyase protein.
Length = 325
Score = 190 bits (464), Expect = 2e-48
Identities = 82/163 (50%), Positives = 112/163 (68%)
Frame = +2
Query: 122 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 301
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 302 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 481
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 482 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
E +RF + A + VRGY+SC +GCPY+G I P +A+
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 187
>CR456884-1|CAG33165.1| 325|Homo sapiens HMGCL protein.
Length = 325
Score = 190 bits (464), Expect = 2e-48
Identities = 82/163 (50%), Positives = 112/163 (68%)
Frame = +2
Query: 122 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 301
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 302 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 481
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 482 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
E +RF + A + VRGY+SC +GCPY+G I P +A+
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 187
>BT009792-1|AAP88794.1| 325|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduri protein.
Length = 325
Score = 190 bits (464), Expect = 2e-48
Identities = 82/163 (50%), Positives = 112/163 (68%)
Frame = +2
Query: 122 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 301
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 302 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 481
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 482 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
E +RF + A + VRGY+SC +GCPY+G I P +A+
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 187
>BC010570-1|AAH10570.1| 325|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduri protein.
Length = 325
Score = 190 bits (464), Expect = 2e-48
Identities = 82/163 (50%), Positives = 112/163 (68%)
Frame = +2
Query: 122 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 301
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 302 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 481
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 482 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
E +RF + A + VRGY+SC +GCPY+G I P +A+
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 187
>U49719-1|AAB19099.1| 305|Homo sapiens hydroxymethylglutaryl-CoA
lyase protein.
Length = 305
Score = 189 bits (460), Expect = 8e-48
Identities = 81/163 (49%), Positives = 112/163 (68%)
Frame = +2
Query: 122 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 301
S+ T+ ++I EVGP+DGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 5 SMGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 64
Query: 302 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 481
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 65 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 124
Query: 482 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
E +RF + A + VRGY+SC +GCPY+G I P +A+
Sbjct: 125 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 167
>AL031295-19|CAI23161.1| 300|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyaseclass T
protein.
Length = 300
Score = 189 bits (460), Expect = 8e-48
Identities = 81/162 (50%), Positives = 111/162 (68%)
Frame = +2
Query: 125 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 304
+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV QM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 305 SDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEE 484
D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+EE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 485 GLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
+RF + A + VRGY+SC +GCPY+G I P +A+
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 162
>BC024194-1|AAH24194.2| 340|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
protein.
Length = 340
Score = 180 bits (439), Expect = 3e-45
Identities = 79/162 (48%), Positives = 110/162 (67%)
Frame = +2
Query: 125 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 304
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV QM
Sbjct: 41 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQM 100
Query: 305 SDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEE 484
+D +VMK I + PGV YPVL PNL+G+ A EI++F A SE FS+KN+NCS+EE
Sbjct: 101 ADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEE 160
Query: 485 GLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
+ +F++V A + RGY+SC +GCPY+G I P+ + +
Sbjct: 161 SMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTE 202
>AK127587-1|BAC87045.1| 297|Homo sapiens protein ( Homo sapiens
cDNA FLJ45682 fis, clone FCBBF3001018, moderately
similar to Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4).
).
Length = 297
Score = 180 bits (439), Expect = 3e-45
Identities = 79/162 (48%), Positives = 110/162 (67%)
Frame = +2
Query: 125 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 304
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV QM
Sbjct: 71 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQM 130
Query: 305 SDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEE 484
+D +VMK I + PGV YPVL PNL+G+ A EI++F A SE FS+KN+NCS+EE
Sbjct: 131 ADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEE 190
Query: 485 GLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
+ +F++V A + RGY+SC +GCPY+G I P+ + +
Sbjct: 191 SMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTE 232
>AL590406-2|CAI40662.1| 241|Homo sapiens protein ( Human DNA
sequence from clone RP11-418P12 on chromosome 6. ).
Length = 241
Score = 116 bits (278), Expect = 9e-26
Identities = 48/103 (46%), Positives = 69/103 (66%)
Frame = +2
Query: 302 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 481
M+D +VMK I + PGV YPVL PNL+G+ A EI++F A SE FS+KN+NCS+E
Sbjct: 1 MADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIE 60
Query: 482 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
E + +F++V A + RGY+SC +GCPY+G I P+ + +
Sbjct: 61 ESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTE 103
>AL590406-1|CAI40661.1| 157|Homo sapiens protein ( Human DNA
sequence from clone RP11-418P12 on chromosome 6. ).
Length = 157
Score = 69.7 bits (163), Expect(2) = 4e-21
Identities = 31/61 (50%), Positives = 43/61 (70%)
Frame = +2
Query: 125 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 304
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV Q+
Sbjct: 47 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQV 106
Query: 305 S 307
+
Sbjct: 107 A 107
Score = 51.6 bits (118), Expect(2) = 4e-21
Identities = 21/46 (45%), Positives = 32/46 (69%)
Frame = +2
Query: 416 EIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYI 553
EI++F A SE FS+KN+NCS+EE + +F++V A + RGY+
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYL 157
>AL590290-1|CAI39775.1| 157|Homo sapiens protein ( Human DNA
sequence from clone RP11-228O6 on chromosome 6. ).
Length = 157
Score = 69.7 bits (163), Expect(2) = 4e-21
Identities = 31/61 (50%), Positives = 43/61 (70%)
Frame = +2
Query: 125 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 304
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV Q+
Sbjct: 47 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQV 106
Query: 305 S 307
+
Sbjct: 107 A 107
Score = 51.6 bits (118), Expect(2) = 4e-21
Identities = 21/46 (45%), Positives = 32/46 (69%)
Frame = +2
Query: 416 EIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYI 553
EI++F A SE FS+KN+NCS+EE + +F++V A + RGY+
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYL 157
>AL137605-1|CAB70838.1| 157|Homo sapiens hypothetical protein
protein.
Length = 157
Score = 69.7 bits (163), Expect(2) = 4e-21
Identities = 31/61 (50%), Positives = 43/61 (70%)
Frame = +2
Query: 125 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 304
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV Q+
Sbjct: 47 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQV 106
Query: 305 S 307
+
Sbjct: 107 A 107
Score = 51.6 bits (118), Expect(2) = 4e-21
Identities = 21/46 (45%), Positives = 32/46 (69%)
Frame = +2
Query: 416 EIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYI 553
EI++F A SE FS+KN+NCS+EE + +F++V A + RGY+
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYL 157
>AF131827-1|AAD20054.1| 191|Homo sapiens Unknown protein.
Length = 191
Score = 61.3 bits (142), Expect = 3e-09
Identities = 22/51 (43%), Positives = 35/51 (68%)
Frame = +2
Query: 458 KNLNCSVEEGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAK 610
KN+NCS+EE + +F++V A + RGY+SC +GCPY+G I P+ + +
Sbjct: 3 KNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTE 53
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 80,296,941
Number of Sequences: 237096
Number of extensions: 1661264
Number of successful extensions: 3329
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 3229
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3329
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 6466646650
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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