Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmmt30e23
(771 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
L07033-1|AAA92733.1| 325|Homo sapiens hydroxymethylglutaryl-CoA... 249 7e-66
CR456884-1|CAG33165.1| 325|Homo sapiens HMGCL protein. 249 7e-66
BT009792-1|AAP88794.1| 325|Homo sapiens 3-hydroxymethyl-3-methy... 249 7e-66
BC010570-1|AAH10570.1| 325|Homo sapiens 3-hydroxymethyl-3-methy... 249 7e-66
BC024194-1|AAH24194.2| 340|Homo sapiens 3-hydroxymethyl-3-methy... 248 2e-65
U49719-1|AAB19099.1| 305|Homo sapiens hydroxymethylglutaryl-CoA... 248 2e-65
AL031295-19|CAI23161.1| 300|Homo sapiens 3-hydroxymethyl-3-meth... 248 2e-65
AK127587-1|BAC87045.1| 297|Homo sapiens protein ( Homo sapiens ... 243 6e-64
AL590406-2|CAI40662.1| 241|Homo sapiens protein ( Human DNA seq... 183 5e-46
AF131827-1|AAD20054.1| 191|Homo sapiens Unknown protein. 128 2e-29
AL590406-1|CAI40661.1| 157|Homo sapiens protein ( Human DNA seq... 70 5e-21
AL590290-1|CAI39775.1| 157|Homo sapiens protein ( Human DNA seq... 70 5e-21
AL137605-1|CAB70838.1| 157|Homo sapiens hypothetical protein pr... 70 5e-21
>L07033-1|AAA92733.1| 325|Homo sapiens hydroxymethylglutaryl-CoA
lyase protein.
Length = 325
Score = 249 bits (610), Expect = 7e-66
Identities = 108/215 (50%), Positives = 149/215 (69%)
Frame = +3
Query: 102 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 281
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 282 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 461
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 462 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGD 641
E +RF + A + VRGY+SC +GCPY+G I P +A++T++ +MGCYE+SLGD
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGD 204
Query: 642 TIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
TIGVGT G ++ +L ++ LA+H HDTYG
Sbjct: 205 TIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 239
>CR456884-1|CAG33165.1| 325|Homo sapiens HMGCL protein.
Length = 325
Score = 249 bits (610), Expect = 7e-66
Identities = 108/215 (50%), Positives = 149/215 (69%)
Frame = +3
Query: 102 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 281
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 282 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 461
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 462 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGD 641
E +RF + A + VRGY+SC +GCPY+G I P +A++T++ +MGCYE+SLGD
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGD 204
Query: 642 TIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
TIGVGT G ++ +L ++ LA+H HDTYG
Sbjct: 205 TIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 239
>BT009792-1|AAP88794.1| 325|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduri protein.
Length = 325
Score = 249 bits (610), Expect = 7e-66
Identities = 108/215 (50%), Positives = 149/215 (69%)
Frame = +3
Query: 102 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 281
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 282 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 461
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 462 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGD 641
E +RF + A + VRGY+SC +GCPY+G I P +A++T++ +MGCYE+SLGD
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGD 204
Query: 642 TIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
TIGVGT G ++ +L ++ LA+H HDTYG
Sbjct: 205 TIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 239
>BC010570-1|AAH10570.1| 325|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduri protein.
Length = 325
Score = 249 bits (610), Expect = 7e-66
Identities = 108/215 (50%), Positives = 149/215 (69%)
Frame = +3
Query: 102 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 281
S+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 25 SMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 84
Query: 282 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 461
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 85 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 144
Query: 462 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGD 641
E +RF + A + VRGY+SC +GCPY+G I P +A++T++ +MGCYE+SLGD
Sbjct: 145 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGD 204
Query: 642 TIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
TIGVGT G ++ +L ++ LA+H HDTYG
Sbjct: 205 TIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 239
>BC024194-1|AAH24194.2| 340|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
protein.
Length = 340
Score = 248 bits (607), Expect = 2e-65
Identities = 108/214 (50%), Positives = 150/214 (70%)
Frame = +3
Query: 105 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 284
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV QM
Sbjct: 41 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQM 100
Query: 285 SDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEE 464
+D +VMK I + PGV YPVL PNL+G+ A EI++F A SE FS+KN+NCS+EE
Sbjct: 101 ADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEE 160
Query: 465 GLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGDT 644
+ +F++V A + RGY+SC +GCPY+G I P+ + +++++L MGCYE+SLGDT
Sbjct: 161 SMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDT 220
Query: 645 IGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
IGVGT GS++R+L ++ P LA+H HDTYG
Sbjct: 221 IGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYG 254
>U49719-1|AAB19099.1| 305|Homo sapiens hydroxymethylglutaryl-CoA
lyase protein.
Length = 305
Score = 248 bits (606), Expect = 2e-65
Identities = 107/215 (49%), Positives = 149/215 (69%)
Frame = +3
Query: 102 SLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQ 281
S+ T+ ++I EVGP+DGLQNE V T +K++LI + AG+ +E+ SFVSPKWV Q
Sbjct: 5 SMGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ 64
Query: 282 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 461
M D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+E
Sbjct: 65 MGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIE 124
Query: 462 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGD 641
E +RF + A + VRGY+SC +GCPY+G I P +A++T++ +MGCYE+SLGD
Sbjct: 125 ESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGD 184
Query: 642 TIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
TIGVGT G ++ +L ++ LA+H HDTYG
Sbjct: 185 TIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 219
>AL031295-19|CAI23161.1| 300|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyaseclass T
protein.
Length = 300
Score = 248 bits (606), Expect = 2e-65
Identities = 107/214 (50%), Positives = 148/214 (69%)
Frame = +3
Query: 105 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 284
+ T+ ++I EVGPRDGLQNE V T +K++LI + AG+ +E+ SFVSPKWV QM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 285 SDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEE 464
D +V+K IQ+ PG+NYPVL PNLKG+E A +E+ IF A SE F++KN+NCS+EE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 465 GLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGDT 644
+RF + A + VRGY+SC +GCPY+G I P +A++T++ +MGCYE+SLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 645 IGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
IGVGT G ++ +L ++ LA+H HDTYG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 214
>AK127587-1|BAC87045.1| 297|Homo sapiens protein ( Homo sapiens
cDNA FLJ45682 fis, clone FCBBF3001018, moderately
similar to Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4).
).
Length = 297
Score = 243 bits (594), Expect = 6e-64
Identities = 106/212 (50%), Positives = 148/212 (69%)
Frame = +3
Query: 105 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 284
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV QM
Sbjct: 71 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQM 130
Query: 285 SDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEE 464
+D +VMK I + PGV YPVL PNL+G+ A EI++F A SE FS+KN+NCS+EE
Sbjct: 131 ADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEE 190
Query: 465 GLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGDT 644
+ +F++V A + RGY+SC +GCPY+G I P+ + +++++L MGCYE+SLGDT
Sbjct: 191 SMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDT 250
Query: 645 IGVGTAGSVRRLLHEILTVAKPEQLALHFHDT 740
IGVGT GS++R+L ++ P LA+H HDT
Sbjct: 251 IGVGTPGSMKRMLESVMKEIPPGALAVHCHDT 282
>AL590406-2|CAI40662.1| 241|Homo sapiens protein ( Human DNA
sequence from clone RP11-418P12 on chromosome 6. ).
Length = 241
Score = 183 bits (446), Expect = 5e-46
Identities = 77/155 (49%), Positives = 109/155 (70%)
Frame = +3
Query: 282 MSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVE 461
M+D +VMK I + PGV YPVL PNL+G+ A EI++F A SE FS+KN+NCS+E
Sbjct: 1 MADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIE 60
Query: 462 EGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMGCYEVSLGD 641
E + +F++V A + RGY+SC +GCPY+G I P+ + +++++L MGCYE+SLGD
Sbjct: 61 ESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGD 120
Query: 642 TIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
TIGVGT GS++R+L ++ P LA+H HDTYG
Sbjct: 121 TIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYG 155
>AF131827-1|AAD20054.1| 191|Homo sapiens Unknown protein.
Length = 191
Score = 128 bits (310), Expect = 2e-29
Identities = 51/103 (49%), Positives = 75/103 (72%)
Frame = +3
Query: 438 KNLNCSVEEGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGPIHPKNIAKITEQLIAMG 617
KN+NCS+EE + +F++V A + RGY+SC +GCPY+G I P+ + +++++L MG
Sbjct: 3 KNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMG 62
Query: 618 CYEVSLGDTIGVGTAGSVRRLLHEILTVAKPEQLALHFHDTYG 746
CYE+SLGDTIGVGT GS++R+L ++ P LA+H HDTYG
Sbjct: 63 CYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYG 105
>AL590406-1|CAI40661.1| 157|Homo sapiens protein ( Human DNA
sequence from clone RP11-418P12 on chromosome 6. ).
Length = 157
Score = 69.7 bits (163), Expect(2) = 5e-21
Identities = 31/61 (50%), Positives = 43/61 (70%)
Frame = +3
Query: 105 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 284
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV Q+
Sbjct: 47 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQV 106
Query: 285 S 287
+
Sbjct: 107 A 107
Score = 51.6 bits (118), Expect(2) = 5e-21
Identities = 21/46 (45%), Positives = 32/46 (69%)
Frame = +3
Query: 396 EIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYI 533
EI++F A SE FS+KN+NCS+EE + +F++V A + RGY+
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYL 157
>AL590290-1|CAI39775.1| 157|Homo sapiens protein ( Human DNA
sequence from clone RP11-228O6 on chromosome 6. ).
Length = 157
Score = 69.7 bits (163), Expect(2) = 5e-21
Identities = 31/61 (50%), Positives = 43/61 (70%)
Frame = +3
Query: 105 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 284
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV Q+
Sbjct: 47 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQV 106
Query: 285 S 287
+
Sbjct: 107 A 107
Score = 51.6 bits (118), Expect(2) = 5e-21
Identities = 21/46 (45%), Positives = 32/46 (69%)
Frame = +3
Query: 396 EIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYI 533
EI++F A SE FS+KN+NCS+EE + +F++V A + RGY+
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYL 157
>AL137605-1|CAB70838.1| 157|Homo sapiens hypothetical protein
protein.
Length = 157
Score = 69.7 bits (163), Expect(2) = 5e-21
Identities = 31/61 (50%), Positives = 43/61 (70%)
Frame = +3
Query: 105 LSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESASFVSPKWVKQM 284
LS + ++I EVGPRDGLQNE VPTDIK+E I+++ G+ +E SFVS +WV Q+
Sbjct: 47 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQV 106
Query: 285 S 287
+
Sbjct: 107 A 107
Score = 51.6 bits (118), Expect(2) = 5e-21
Identities = 21/46 (45%), Positives = 32/46 (69%)
Frame = +3
Query: 396 EIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYI 533
EI++F A SE FS+KN+NCS+EE + +F++V A + RGY+
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYL 157
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 108,006,798
Number of Sequences: 237096
Number of extensions: 2404467
Number of successful extensions: 4803
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 4604
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4803
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 9311505506
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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