Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmmt28d23
(478 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosid... 147 2e-35
BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosid... 143 2e-34
AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosid... 143 2e-34
AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosid... 143 2e-34
AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosid... 143 2e-34
AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic beta-glucosid... 143 2e-34
X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for ... 141 1e-33
M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolas... 141 1e-33
AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin hydro... 141 1e-33
AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein. 141 1e-33
AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein. 134 1e-31
BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein. 121 1e-27
BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein. 121 1e-27
AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protei... 121 1e-27
Z92540-2|CAC94767.1| 273|Homo sapiens 179I15.1 (klotho) protein. 111 1e-24
AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein. 111 1e-24
AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL) pro... 111 1e-24
AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL) pro... 111 1e-24
AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein. 111 1e-24
BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein. 103 2e-22
BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein. 103 2e-22
BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein. 103 4e-22
Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein. 42 8e-04
AY574903-1|AAT81412.1| 1127|Homo sapiens regulated in COPD kinas... 29 8.3
AY574902-1|AAT81411.1| 1215|Homo sapiens regulated in COPD kinas... 29 8.3
AY574901-1|AAT81410.1| 1328|Homo sapiens regulated in COPD kinas... 29 8.3
>AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 147 bits (356), Expect = 2e-35
Identities = 63/134 (47%), Positives = 83/134 (61%), Gaps = 2/134 (1%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFH 433
D++ +LGL YRFSLSW RL+P G + I++ G YYN +ID LL G+ P+VT++H
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH 120
Query: 434 WDLPPXF--AGSWW 469
+DLP G WW
Sbjct: 121 FDLPQTLEDQGGWW 134
>BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 143 bits (347), Expect = 2e-34
Identities = 63/136 (46%), Positives = 83/136 (61%), Gaps = 1/136 (0%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFH 433
D++ +LGL YRFSLSW RL+P G + I++ G YYN +ID LL G+ P+VT++H
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH 120
Query: 434 WDLPPXFAG-SWWLDE 478
+DLP WL E
Sbjct: 121 FDLPQTLEDQGGWLSE 136
>AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosidase
variant protein.
Length = 469
Score = 143 bits (347), Expect = 2e-34
Identities = 63/136 (46%), Positives = 83/136 (61%), Gaps = 1/136 (0%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFH 433
D++ +LGL YRFSLSW RL+P G + I++ G YYN +ID LL G+ P+VT++H
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH 120
Query: 434 WDLPPXFAG-SWWLDE 478
+DLP WL E
Sbjct: 121 FDLPQTLEDQGGWLSE 136
>AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 143 bits (347), Expect = 2e-34
Identities = 63/136 (46%), Positives = 83/136 (61%), Gaps = 1/136 (0%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFH 433
D++ +LGL YRFSLSW RL+P G + I++ G YYN +ID LL G+ P+VT++H
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH 120
Query: 434 WDLPPXFAG-SWWLDE 478
+DLP WL E
Sbjct: 121 FDLPQTLEDQGGWLSE 136
>AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 143 bits (347), Expect = 2e-34
Identities = 63/136 (46%), Positives = 83/136 (61%), Gaps = 1/136 (0%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFH 433
D++ +LGL YRFSLSW RL+P G + I++ G YYN +ID LL G+ P+VT++H
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH 120
Query: 434 WDLPPXFAG-SWWLDE 478
+DLP WL E
Sbjct: 121 FDLPQTLEDQGGWLSE 136
>AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic
beta-glucosidase-like protein-1 protein.
Length = 469
Score = 143 bits (347), Expect = 2e-34
Identities = 63/136 (46%), Positives = 83/136 (61%), Gaps = 1/136 (0%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFH 433
D++ +LGL YRFSLSW RL+P G + I++ G YYN +ID LL G+ P+VT++H
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH 120
Query: 434 WDLPPXFAG-SWWLDE 478
+DLP WL E
Sbjct: 121 FDLPQTLEDQGGWLSE 136
>X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for
lactase-phlorizin hydrolase LPH (EC 3.2.1.23-62). ).
Length = 1927
Score = 141 bits (341), Expect = 1e-33
Identities = 61/132 (46%), Positives = 81/132 (61%), Gaps = 2/132 (1%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TF F +G +S++YQ+EGAW+ KG SIWD HT + D GD+ CDSYH +
Sbjct: 902 TFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDA 961
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHW 436
D+ M L + YRFS+SW R+ PTG ++ I+ G YYN LI+GL+ I P+VT+FHW
Sbjct: 962 DLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHW 1021
Query: 437 DLPPXF--AGSW 466
DLP G W
Sbjct: 1022 DLPQALQDIGGW 1033
Score = 135 bits (326), Expect = 9e-32
Identities = 65/131 (49%), Positives = 79/131 (60%), Gaps = 2/131 (1%)
Frame = +2
Query: 80 FPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWERD 259
FP GF + AASA+YQ+EGAW KG SIWD HT P + + GDV CDSYH D
Sbjct: 1377 FPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHT-PLRVENDAIGDVACDSYHKIAED 1435
Query: 260 IEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHWD 439
+ LG+ YRFS+SW R++P G + I+E G YY LID LL I+P VTI+HWD
Sbjct: 1436 LVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWD 1495
Query: 440 LPPXF--AGSW 466
LP G W
Sbjct: 1496 LPQTLQDVGGW 1506
Score = 112 bits (270), Expect = 5e-25
Identities = 57/136 (41%), Positives = 74/136 (54%), Gaps = 6/136 (4%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNG----DVTCDSYH 244
TFP GF +GA++ ++ VEG W +G SIWD P ++ T G +V DSYH
Sbjct: 381 TFPEGFLWGASTGAFNVEGGWAEGGRGVSIWD------PRRPLNTTEGQATLEVASDSYH 434
Query: 245 LWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVT 424
D+ + L Y+FS+SW R+ P G + S G YYN LID L D GIEP+ T
Sbjct: 435 KVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMAT 494
Query: 425 IFHWDLPPXFA--GSW 466
+FHWDLP G W
Sbjct: 495 LFHWDLPQALQDHGGW 510
Score = 37.1 bits (82), Expect = 0.031
Identities = 16/51 (31%), Positives = 26/51 (50%)
Frame = +2
Query: 293 YRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHWDLP 445
Y+ LSW +L+P G + E + Y L+ L ++P+V + H LP
Sbjct: 87 YKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLP 137
>M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolase
protein.
Length = 1927
Score = 141 bits (341), Expect = 1e-33
Identities = 61/132 (46%), Positives = 81/132 (61%), Gaps = 2/132 (1%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TF F +G +S++YQ+EGAW+ KG SIWD HT + D GD+ CDSYH +
Sbjct: 902 TFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDA 961
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHW 436
D+ M L + YRFS+SW R+ PTG ++ I+ G YYN LI+GL+ I P+VT+FHW
Sbjct: 962 DLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHW 1021
Query: 437 DLPPXF--AGSW 466
DLP G W
Sbjct: 1022 DLPQALQDIGGW 1033
Score = 135 bits (326), Expect = 9e-32
Identities = 65/131 (49%), Positives = 79/131 (60%), Gaps = 2/131 (1%)
Frame = +2
Query: 80 FPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWERD 259
FP GF + AASA+YQ+EGAW KG SIWD HT P + + GDV CDSYH D
Sbjct: 1377 FPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHT-PLRVENDAIGDVACDSYHKIAED 1435
Query: 260 IEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHWD 439
+ LG+ YRFS+SW R++P G + I+E G YY LID LL I+P VTI+HWD
Sbjct: 1436 LVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWD 1495
Query: 440 LPPXF--AGSW 466
LP G W
Sbjct: 1496 LPQTLQDVGGW 1506
Score = 112 bits (270), Expect = 5e-25
Identities = 57/136 (41%), Positives = 74/136 (54%), Gaps = 6/136 (4%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNG----DVTCDSYH 244
TFP GF +GA++ ++ VEG W +G SIWD P ++ T G +V DSYH
Sbjct: 381 TFPEGFLWGASTGAFNVEGGWAEGGRGVSIWD------PRRPLNTTEGQATLEVASDSYH 434
Query: 245 LWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVT 424
D+ + L Y+FS+SW R+ P G + S G YYN LID L D GIEP+ T
Sbjct: 435 KVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMAT 494
Query: 425 IFHWDLPPXFA--GSW 466
+FHWDLP G W
Sbjct: 495 LFHWDLPQALQDHGGW 510
Score = 37.1 bits (82), Expect = 0.031
Identities = 16/51 (31%), Positives = 26/51 (50%)
Frame = +2
Query: 293 YRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHWDLP 445
Y+ LSW +L+P G + E + Y L+ L ++P+V + H LP
Sbjct: 87 YKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLP 137
>AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin
hydrolase-1 protein.
Length = 1003
Score = 141 bits (341), Expect = 1e-33
Identities = 61/132 (46%), Positives = 81/132 (61%), Gaps = 2/132 (1%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TF F +G +S++YQ+EGAW+ KG SIWD HT + D GD+ CDSYH +
Sbjct: 334 TFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDA 393
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHW 436
D+ M L + YRFS+SW R+ PTG ++ I+ G YYN LI+GL+ I P+VT+FHW
Sbjct: 394 DLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHW 453
Query: 437 DLPPXF--AGSW 466
DLP G W
Sbjct: 454 DLPQALQDIGGW 465
Score = 135 bits (326), Expect = 9e-32
Identities = 65/131 (49%), Positives = 79/131 (60%), Gaps = 2/131 (1%)
Frame = +2
Query: 80 FPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWERD 259
FP GF + AASA+YQ+EGAW KG SIWD HT P + + GDV CDSYH D
Sbjct: 809 FPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHT-PLRVENDAIGDVACDSYHKIAED 867
Query: 260 IEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHWD 439
+ LG+ YRFS+SW R++P G + I+E G YY LID LL I+P VTI+HWD
Sbjct: 868 LVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWD 927
Query: 440 LPPXF--AGSW 466
LP G W
Sbjct: 928 LPQTLQDVGGW 938
>AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein.
Length = 1927
Score = 141 bits (341), Expect = 1e-33
Identities = 61/132 (46%), Positives = 81/132 (61%), Gaps = 2/132 (1%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TF F +G +S++YQ+EGAW+ KG SIWD HT + D GD+ CDSYH +
Sbjct: 902 TFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDA 961
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHW 436
D+ M L + YRFS+SW R+ PTG ++ I+ G YYN LI+GL+ I P+VT+FHW
Sbjct: 962 DLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHW 1021
Query: 437 DLPPXF--AGSW 466
DLP G W
Sbjct: 1022 DLPQALQDIGGW 1033
Score = 135 bits (326), Expect = 9e-32
Identities = 65/131 (49%), Positives = 79/131 (60%), Gaps = 2/131 (1%)
Frame = +2
Query: 80 FPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWERD 259
FP GF + AASA+YQ+EGAW KG SIWD HT P + + GDV CDSYH D
Sbjct: 1377 FPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHT-PLRVENDAIGDVACDSYHKIAED 1435
Query: 260 IEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHWD 439
+ LG+ YRFS+SW R++P G + I+E G YY LID LL I+P VTI+HWD
Sbjct: 1436 LVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWD 1495
Query: 440 LPPXF--AGSW 466
LP G W
Sbjct: 1496 LPQTLQDVGGW 1506
Score = 112 bits (270), Expect = 5e-25
Identities = 57/136 (41%), Positives = 74/136 (54%), Gaps = 6/136 (4%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNG----DVTCDSYH 244
TFP GF +GA++ ++ VEG W +G SIWD P ++ T G +V DSYH
Sbjct: 381 TFPEGFLWGASTGAFNVEGGWAEGGRGVSIWD------PRRPLNTTEGQATLEVASDSYH 434
Query: 245 LWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVT 424
D+ + L Y+FS+SW R+ P G + S G YYN LID L D GIEP+ T
Sbjct: 435 KVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMAT 494
Query: 425 IFHWDLPPXFA--GSW 466
+FHWDLP G W
Sbjct: 495 LFHWDLPQALQDHGGW 510
Score = 37.1 bits (82), Expect = 0.031
Identities = 16/51 (31%), Positives = 26/51 (50%)
Frame = +2
Query: 293 YRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHWDLP 445
Y+ LSW +L+P G + E + Y L+ L ++P+V + H LP
Sbjct: 87 YKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLP 137
>AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein.
Length = 567
Score = 134 bits (325), Expect = 1e-31
Identities = 58/124 (46%), Positives = 82/124 (66%), Gaps = 1/124 (0%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TFP GF +G S++YQ EGAW+ KG SIWD H+ ++ DV CD Y+ +
Sbjct: 36 TFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQE 95
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGF-SNKISEDGQKYYNNLIDGLLDKGIEPLVTIFH 433
DI + EL ++ YRFSLSWPRL+PTG + ++++ G ++Y++LID LL I P+VT+ H
Sbjct: 96 DIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHH 155
Query: 434 WDLP 445
WDLP
Sbjct: 156 WDLP 159
>BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 121 bits (292), Expect = 1e-27
Identities = 54/123 (43%), Positives = 77/123 (62%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TFP F +G + + QVEG+W KG SIWD +HT + + TNG + DSY E+
Sbjct: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS-TNG--SSDSYIFLEK 136
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHW 436
D+ +G+ FY+FS+SWPRL P G + G +YY+ L+D L+ + IEP+VT++HW
Sbjct: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196
Query: 437 DLP 445
DLP
Sbjct: 197 DLP 199
Score = 49.6 bits (113), Expect = 6e-06
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 13/145 (8%)
Frame = +2
Query: 80 FPPGFKFGAASASYQVEGAWN---VSDKGESIWD----RLVHTKPEAIMDLTNGDVTCDS 238
FP F +G + + E + SD +W+ RL+H + E + L C
Sbjct: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLH-RVEGVR-LKTRPAQCTD 578
Query: 239 YHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPL 418
+ ++ +EM + + YRF+L W ++PTG + ++ +YY ++ L GI +
Sbjct: 579 FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAM 638
Query: 419 VTIF-----HWDLP-PXFAGSWWLD 475
VT++ H LP P WL+
Sbjct: 639 VTLYYPTHAHLGLPEPLLHADGWLN 663
>BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 121 bits (292), Expect = 1e-27
Identities = 54/123 (43%), Positives = 77/123 (62%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TFP F +G + + QVEG+W KG SIWD +HT + + TNG + DSY E+
Sbjct: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS-TNG--SSDSYIFLEK 136
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHW 436
D+ +G+ FY+FS+SWPRL P G + G +YY+ L+D L+ + IEP+VT++HW
Sbjct: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196
Query: 437 DLP 445
DLP
Sbjct: 197 DLP 199
Score = 49.6 bits (113), Expect = 6e-06
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 13/145 (8%)
Frame = +2
Query: 80 FPPGFKFGAASASYQVEGAWN---VSDKGESIWD----RLVHTKPEAIMDLTNGDVTCDS 238
FP F +G + + E + SD +W+ RL+H + E + L C
Sbjct: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLH-RVEGVR-LKTRPAQCTD 578
Query: 239 YHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPL 418
+ ++ +EM + + YRF+L W ++PTG + ++ +YY ++ L GI +
Sbjct: 579 FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAM 638
Query: 419 VTIF-----HWDLP-PXFAGSWWLD 475
VT++ H LP P WL+
Sbjct: 639 VTLYYPTHAHLGLPEPLLHADGWLN 663
>AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protein
protein.
Length = 1044
Score = 121 bits (292), Expect = 1e-27
Identities = 54/123 (43%), Positives = 77/123 (62%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWER 256
TFP F +G + + QVEG+W KG SIWD +HT + + TNG + DSY E+
Sbjct: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS-TNG--SSDSYIFLEK 136
Query: 257 DIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPLVTIFHW 436
D+ +G+ FY+FS+SWPRL P G + G +YY+ L+D L+ + IEP+VT++HW
Sbjct: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196
Query: 437 DLP 445
DLP
Sbjct: 197 DLP 199
Score = 49.6 bits (113), Expect = 6e-06
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 13/145 (8%)
Frame = +2
Query: 80 FPPGFKFGAASASYQVEGAWN---VSDKGESIWD----RLVHTKPEAIMDLTNGDVTCDS 238
FP F +G + + E + SD +W+ RL+H + E + L C
Sbjct: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLH-RVEGVR-LKTRPAQCTD 578
Query: 239 YHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEPL 418
+ ++ +EM + + YRF+L W ++PTG + ++ +YY ++ L GI +
Sbjct: 579 FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAM 638
Query: 419 VTIF-----HWDLP-PXFAGSWWLD 475
VT++ H LP P WL+
Sbjct: 639 VTLYYPTHAHLGLPEPLLHADGWLN 663
>Z92540-2|CAC94767.1| 273|Homo sapiens 179I15.1 (klotho) protein.
Length = 273
Score = 111 bits (267), Expect = 1e-24
Identities = 56/138 (40%), Positives = 75/138 (54%), Gaps = 15/138 (10%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTN------------- 217
TFP GF + SA+YQ EG W KG SIWD H D N
Sbjct: 60 TFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQP 119
Query: 218 --GDVTCDSYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDG 391
GDV DSY+ RD E ELG+ YRFS+SW R++P G + + +G +YY L++
Sbjct: 120 ATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLER 179
Query: 392 LLDKGIEPLVTIFHWDLP 445
L + G++P+VT++HWDLP
Sbjct: 180 LRELGVQPVVTLYHWDLP 197
>AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 111 bits (267), Expect = 1e-24
Identities = 56/138 (40%), Positives = 75/138 (54%), Gaps = 15/138 (10%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTN------------- 217
TFP GF + SA+YQ EG W KG SIWD H D N
Sbjct: 60 TFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQP 119
Query: 218 --GDVTCDSYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDG 391
GDV DSY+ RD E ELG+ YRFS+SW R++P G + + +G +YY L++
Sbjct: 120 ATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLER 179
Query: 392 LLDKGIEPLVTIFHWDLP 445
L + G++P+VT++HWDLP
Sbjct: 180 LRELGVQPVVTLYHWDLP 197
Score = 42.3 bits (95), Expect = 8e-04
Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWN-VSDKGESIWDRLVHTKPEAIMDLTNGDVT------CD 235
TFP F +G QV+ + +D +WD VH I +G VT C
Sbjct: 518 TFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIK--VDGVVTKKRKSYCV 573
Query: 236 SYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEP 415
+ + I + E+ + +RFSL W ++P G ++++ +YY + L+ I P
Sbjct: 574 DFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITP 633
Query: 416 LVTIF 430
+V ++
Sbjct: 634 VVALW 638
>AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL)
protein.
Length = 549
Score = 111 bits (267), Expect = 1e-24
Identities = 56/138 (40%), Positives = 75/138 (54%), Gaps = 15/138 (10%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTN------------- 217
TFP GF + SA+YQ EG W KG SIWD H D N
Sbjct: 60 TFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQP 119
Query: 218 --GDVTCDSYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDG 391
GDV DSY+ RD E ELG+ YRFS+SW R++P G + + +G +YY L++
Sbjct: 120 ATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLER 179
Query: 392 LLDKGIEPLVTIFHWDLP 445
L + G++P+VT++HWDLP
Sbjct: 180 LRELGVQPVVTLYHWDLP 197
>AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL)
protein.
Length = 1012
Score = 111 bits (267), Expect = 1e-24
Identities = 56/138 (40%), Positives = 75/138 (54%), Gaps = 15/138 (10%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTN------------- 217
TFP GF + SA+YQ EG W KG SIWD H D N
Sbjct: 60 TFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQP 119
Query: 218 --GDVTCDSYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDG 391
GDV DSY+ RD E ELG+ YRFS+SW R++P G + + +G +YY L++
Sbjct: 120 ATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLER 179
Query: 392 LLDKGIEPLVTIFHWDLP 445
L + G++P+VT++HWDLP
Sbjct: 180 LRELGVQPVVTLYHWDLP 197
Score = 42.3 bits (95), Expect = 8e-04
Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWN-VSDKGESIWDRLVHTKPEAIMDLTNGDVT------CD 235
TFP F +G QV+ + +D +WD VH I +G VT C
Sbjct: 518 TFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIK--VDGVVTKKRKSYCV 573
Query: 236 SYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEP 415
+ + I + E+ + +RFSL W ++P G ++++ +YY + L+ I P
Sbjct: 574 DFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITP 633
Query: 416 LVTIF 430
+V ++
Sbjct: 634 VVALW 638
>AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 111 bits (267), Expect = 1e-24
Identities = 56/138 (40%), Positives = 75/138 (54%), Gaps = 15/138 (10%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTN------------- 217
TFP GF + SA+YQ EG W KG SIWD H D N
Sbjct: 60 TFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQP 119
Query: 218 --GDVTCDSYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDG 391
GDV DSY+ RD E ELG+ YRFS+SW R++P G + + +G +YY L++
Sbjct: 120 ATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLER 179
Query: 392 LLDKGIEPLVTIFHWDLP 445
L + G++P+VT++HWDLP
Sbjct: 180 LRELGVQPVVTLYHWDLP 197
Score = 42.3 bits (95), Expect = 8e-04
Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWN-VSDKGESIWDRLVHTKPEAIMDLTNGDVT------CD 235
TFP F +G QV+ + +D +WD VH I +G VT C
Sbjct: 518 TFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIK--VDGVVTKKRKSYCV 573
Query: 236 SYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEP 415
+ + I + E+ + +RFSL W ++P G ++++ +YY + L+ I P
Sbjct: 574 DFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITP 633
Query: 416 LVTIF 430
+V ++
Sbjct: 634 VVALW 638
>BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 103 bits (248), Expect = 2e-22
Identities = 44/94 (46%), Positives = 58/94 (61%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISE 355
D++ +LGL YRFSLSW RL+P G + I++
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQ 94
>BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 103 bits (248), Expect = 2e-22
Identities = 44/94 (46%), Positives = 58/94 (61%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISE 355
D++ +LGL YRFSLSW RL+P G + I++
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQ 94
>BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 103 bits (246), Expect = 4e-22
Identities = 44/94 (46%), Positives = 58/94 (61%)
Frame = +2
Query: 74 LTFPPGFKFGAASASYQVEGAWNVSDKGESIWDRLVHTKPEAIMDLTNGDVTCDSYHLWE 253
+ FP GF + AA+A+YQVEG W+ KG +WD H E + GDV C SY LWE
Sbjct: 1 MAFPAGFGWAAATAAYQVEGGWDADGKGLCVWDTFTHQGGERVFKNQTGDVACGSYTLWE 60
Query: 254 RDIEMATELGLHFYRFSLSWPRLMPTGFSNKISE 355
D++ +LGL YRFSLSW RL+P G + I++
Sbjct: 61 EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQ 94
>Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein.
Length = 739
Score = 42.3 bits (95), Expect = 8e-04
Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Frame = +2
Query: 77 TFPPGFKFGAASASYQVEGAWN-VSDKGESIWDRLVHTKPEAIMDLTNGDVT------CD 235
TFP F +G QV+ + +D +WD VH I +G VT C
Sbjct: 245 TFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIK--VDGVVTKKRKSYCV 300
Query: 236 SYHLWERDIEMATELGLHFYRFSLSWPRLMPTGFSNKISEDGQKYYNNLIDGLLDKGIEP 415
+ + I + E+ + +RFSL W ++P G ++++ +YY + L+ I P
Sbjct: 301 DFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITP 360
Query: 416 LVTIF 430
+V ++
Sbjct: 361 VVALW 365
>AY574903-1|AAT81412.1| 1127|Homo sapiens regulated in COPD kinase
transcript variant 3 protein.
Length = 1127
Score = 29.1 bits (62), Expect = 8.3
Identities = 14/32 (43%), Positives = 17/32 (53%)
Frame = -3
Query: 182 GLADPICFHLCR*HSKLPQLGMKLMLHRT*SP 87
GL DP + L R K+PQ+ K HRT P
Sbjct: 578 GLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKP 609
>AY574902-1|AAT81411.1| 1215|Homo sapiens regulated in COPD kinase
transcript variant 2 protein.
Length = 1215
Score = 29.1 bits (62), Expect = 8.3
Identities = 14/32 (43%), Positives = 17/32 (53%)
Frame = -3
Query: 182 GLADPICFHLCR*HSKLPQLGMKLMLHRT*SP 87
GL DP + L R K+PQ+ K HRT P
Sbjct: 465 GLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKP 496
>AY574901-1|AAT81410.1| 1328|Homo sapiens regulated in COPD kinase
transcript variant 1 protein.
Length = 1328
Score = 29.1 bits (62), Expect = 8.3
Identities = 14/32 (43%), Positives = 17/32 (53%)
Frame = -3
Query: 182 GLADPICFHLCR*HSKLPQLGMKLMLHRT*SP 87
GL DP + L R K+PQ+ K HRT P
Sbjct: 578 GLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKP 609
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 77,821,638
Number of Sequences: 237096
Number of extensions: 1731234
Number of successful extensions: 2979
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 2828
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2963
length of database: 76,859,062
effective HSP length: 84
effective length of database: 56,942,998
effective search space used: 4213781852
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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