Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= bmmt26o01
(711 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC109320-1|AAI09321.1| 314|Homo sapiens sirtuin (silent mating ... 156 8e-38
BC109319-1|AAI09320.1| 314|Homo sapiens sirtuin (silent mating ... 156 8e-38
AF083109-1|AAD40852.1| 314|Homo sapiens sirtuin type 4 protein. 156 8e-38
AC003982-1|AAB95634.1| 326|Homo sapiens WUGSC:H_166H1.1 protein. 144 3e-34
BC000126-1|AAH00126.1| 310|Homo sapiens sirtuin (silent mating ... 71 3e-12
AL441883-2|CAI19838.1| 310|Homo sapiens sirtuin (silent mating ... 71 3e-12
AL441883-1|CAI19837.1| 299|Homo sapiens sirtuin (silent mating ... 71 3e-12
AK000355-1|BAA91107.1| 299|Homo sapiens protein ( Homo sapiens ... 71 3e-12
AF083110-1|AAD40853.1| 310|Homo sapiens sirtuin type 5 protein. 71 3e-12
BC012499-1|AAH12499.1| 555|Homo sapiens SIRT1 protein protein. 61 3e-09
DQ278604-1|ABB72675.1| 747|Homo sapiens sirtuin (silent mating ... 58 2e-08
AL133551-8|CAI16036.1| 747|Homo sapiens sirtuin (silent mating ... 58 2e-08
AF235040-1|AAG38486.1| 747|Homo sapiens SIR2alpha protein protein. 58 2e-08
AF083106-1|AAD40849.2| 747|Homo sapiens sirtuin type 1 protein. 58 2e-08
AC006930-1|AAD15478.1| 377|Homo sapiens R33423_1 protein. 57 5e-08
BC003547-1|AAH03547.1| 352|Homo sapiens sirtuin (silent mating ... 51 4e-06
BC003012-1|AAH03012.1| 352|Homo sapiens sirtuin (silent mating ... 51 4e-06
AY030277-1|AAK51133.1| 352|Homo sapiens SIRT2 protein. 51 4e-06
AF095714-1|AAD45971.1| 352|Homo sapiens silencing information r... 51 4e-06
AF083107-1|AAD40850.2| 389|Homo sapiens sirtuin type 2 protein. 51 4e-06
BC001042-1|AAH01042.1| 399|Homo sapiens sirtuin (silent mating ... 49 1e-05
AF131800-1|AAD20046.1| 254|Homo sapiens Similar to rat 5E5 anti... 49 1e-05
AF083108-1|AAD40851.1| 399|Homo sapiens sirtuin type 3 protein. 49 1e-05
AJ505014-1|CAD43717.1| 369|Homo sapiens sirtuin type 2 protein. 48 3e-05
CR457200-1|CAG33481.1| 355|Homo sapiens SIRT6 protein. 46 2e-04
BC005026-1|AAH05026.1| 355|Homo sapiens sirtuin (silent mating ... 46 2e-04
AK074992-1|BAC11340.1| 134|Homo sapiens protein ( Homo sapiens ... 46 2e-04
AK074810-1|BAC11222.1| 355|Homo sapiens protein ( Homo sapiens ... 46 2e-04
AF233396-1|AAF43432.1| 355|Homo sapiens sir2-related protein ty... 46 2e-04
AF160214-1|AAF67015.1| 373|Homo sapiens silent information regu... 46 2e-04
BC028220-1|AAH28220.1| 328|Homo sapiens SIRT6 protein protein. 41 0.005
BC004218-1|AAH04218.1| 256|Homo sapiens SIRT6 protein protein. 41 0.005
AL137276-1|CAB70674.1| 118|Homo sapiens hypothetical protein pr... 36 0.14
AY960861-1|AAX57561.1| 117|Homo sapiens anti-oxLDL immunoglobul... 30 9.4
>BC109320-1|AAI09321.1| 314|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 4 (S. cerevisiae)
protein.
Length = 314
Score = 156 bits (378), Expect = 8e-38
Identities = 81/157 (51%), Positives = 99/157 (63%)
Frame = +1
Query: 241 GKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMES 420
GK+ +VTQNVD LH KAGS ++ ELHG V CL C + R LQE NP +
Sbjct: 135 GKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSA 194
Query: 421 SFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVTSSD 600
+ PDGDV LS EQV F+ P C +C G LKPD+VFFGD V +V+ V K V +D
Sbjct: 195 EAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEAD 254
Query: 601 AVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGPTR 711
++ V+GSSL VYS YR IL A ++ IAILNIGPTR
Sbjct: 255 SLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTR 291
Score = 91.1 bits (216), Expect = 4e-18
Identities = 37/64 (57%), Positives = 49/64 (76%)
Frame = +2
Query: 2 IPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPNVTHLCIRE 181
IPDYRSE VGLYAR++ +PIQ+ +FV+ +RQRYWARN++GWP+FS QPN H +
Sbjct: 71 IPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALST 130
Query: 182 LEKV 193
EK+
Sbjct: 131 WEKL 134
>BC109319-1|AAI09320.1| 314|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 4 (S. cerevisiae)
protein.
Length = 314
Score = 156 bits (378), Expect = 8e-38
Identities = 81/157 (51%), Positives = 99/157 (63%)
Frame = +1
Query: 241 GKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMES 420
GK+ +VTQNVD LH KAGS ++ ELHG V CL C + R LQE NP +
Sbjct: 135 GKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSA 194
Query: 421 SFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVTSSD 600
+ PDGDV LS EQV F+ P C +C G LKPD+VFFGD V +V+ V K V +D
Sbjct: 195 EAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEAD 254
Query: 601 AVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGPTR 711
++ V+GSSL VYS YR IL A ++ IAILNIGPTR
Sbjct: 255 SLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTR 291
Score = 91.1 bits (216), Expect = 4e-18
Identities = 37/64 (57%), Positives = 49/64 (76%)
Frame = +2
Query: 2 IPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPNVTHLCIRE 181
IPDYRSE VGLYAR++ +PIQ+ +FV+ +RQRYWARN++GWP+FS QPN H +
Sbjct: 71 IPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALST 130
Query: 182 LEKV 193
EK+
Sbjct: 131 WEKL 134
>AF083109-1|AAD40852.1| 314|Homo sapiens sirtuin type 4 protein.
Length = 314
Score = 156 bits (378), Expect = 8e-38
Identities = 81/157 (51%), Positives = 99/157 (63%)
Frame = +1
Query: 241 GKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMES 420
GK+ +VTQNVD LH KAGS ++ ELHG V CL C + R LQE NP +
Sbjct: 135 GKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSA 194
Query: 421 SFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVTSSD 600
+ PDGDV LS EQV F+ P C +C G LKPD+VFFGD V +V+ V K V +D
Sbjct: 195 EAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEAD 254
Query: 601 AVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGPTR 711
++ V+GSSL VYS YR IL A ++ IAILNIGPTR
Sbjct: 255 SLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTR 291
Score = 91.1 bits (216), Expect = 4e-18
Identities = 37/64 (57%), Positives = 49/64 (76%)
Frame = +2
Query: 2 IPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPNVTHLCIRE 181
IPDYRSE VGLYAR++ +PIQ+ +FV+ +RQRYWARN++GWP+FS QPN H +
Sbjct: 71 IPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALST 130
Query: 182 LEKV 193
EK+
Sbjct: 131 WEKL 134
>AC003982-1|AAB95634.1| 326|Homo sapiens WUGSC:H_166H1.1 protein.
Length = 326
Score = 144 bits (349), Expect = 3e-34
Identities = 82/169 (48%), Positives = 101/169 (59%), Gaps = 12/169 (7%)
Frame = +1
Query: 241 GKVTSIVTQNVDRLHHKAGSEKVIELHGT---SYL---------VQCLKCPYEIDRHELQ 384
GK+ +VTQNVD LH KAGS ++ ELHG +Y V CL C + R LQ
Sbjct: 135 GKLYWLVTQNVDALHTKAGSRRLTELHGCMDRAYCSVSVFLGSRVLCLDCGEQTPRGVLQ 194
Query: 385 EILTENNPDMESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYR 564
E NP + + PDGDV LS EQV F+ P C +C G LKPD+VFFGD V +
Sbjct: 195 ERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDK 254
Query: 565 VEQVRKEVTSSDAVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGPTR 711
V+ V K V +D++ V+GSSL VYS YR IL A ++ IAILNIGPTR
Sbjct: 255 VDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTR 303
Score = 91.1 bits (216), Expect = 4e-18
Identities = 37/64 (57%), Positives = 49/64 (76%)
Frame = +2
Query: 2 IPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPNVTHLCIRE 181
IPDYRSE VGLYAR++ +PIQ+ +FV+ +RQRYWARN++GWP+FS QPN H +
Sbjct: 71 IPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALST 130
Query: 182 LEKV 193
EK+
Sbjct: 131 WEKL 134
>BC000126-1|AAH00126.1| 310|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 5 (S. cerevisiae)
protein.
Length = 310
Score = 71.3 bits (167), Expect = 3e-12
Identities = 39/136 (28%), Positives = 73/136 (53%), Gaps = 2/136 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++G+ ++TQN+D LH KAG++ ++E+HG+ + +C C + ++ +P
Sbjct: 130 KQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYK--------SPIC 181
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPK--CEGPLKPDIVFFGDNVPKYRVEQVRKEV 588
+ P+ + + VEK P C + C G L+P +V+FG+N+ +E+V +E+
Sbjct: 182 PALSGKGAPEPGTQDASIPVEKL--PRCEEAGCGGLLRPHVVWFGENLDPAILEEVDREL 239
Query: 589 TSSDAVFVMGSSLTVY 636
D V+G+S VY
Sbjct: 240 AHCDLCLVVGTSSVVY 255
>AL441883-2|CAI19838.1| 310|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 5 (S. cerevisiae)
protein.
Length = 310
Score = 71.3 bits (167), Expect = 3e-12
Identities = 39/136 (28%), Positives = 73/136 (53%), Gaps = 2/136 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++G+ ++TQN+D LH KAG++ ++E+HG+ + +C C + ++ +P
Sbjct: 130 KQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYK--------SPIC 181
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPK--CEGPLKPDIVFFGDNVPKYRVEQVRKEV 588
+ P+ + + VEK P C + C G L+P +V+FG+N+ +E+V +E+
Sbjct: 182 PALSGKGAPEPGTQDASIPVEKL--PRCEEAGCGGLLRPHVVWFGENLDPAILEEVDREL 239
Query: 589 TSSDAVFVMGSSLTVY 636
D V+G+S VY
Sbjct: 240 AHCDLCLVVGTSSVVY 255
>AL441883-1|CAI19837.1| 299|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 5 (S. cerevisiae)
protein.
Length = 299
Score = 71.3 bits (167), Expect = 3e-12
Identities = 39/136 (28%), Positives = 73/136 (53%), Gaps = 2/136 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++G+ ++TQN+D LH KAG++ ++E+HG+ + +C C + ++ +P
Sbjct: 130 KQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYK--------SPIC 181
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPK--CEGPLKPDIVFFGDNVPKYRVEQVRKEV 588
+ P+ + + VEK P C + C G L+P +V+FG+N+ +E+V +E+
Sbjct: 182 PALSGKGAPEPGTQDASIPVEKL--PRCEEAGCGGLLRPHVVWFGENLDPAILEEVDREL 239
Query: 589 TSSDAVFVMGSSLTVY 636
D V+G+S VY
Sbjct: 240 AHCDLCLVVGTSSVVY 255
>AK000355-1|BAA91107.1| 299|Homo sapiens protein ( Homo sapiens
cDNA FLJ20348 fis, clone HEP13915. ).
Length = 299
Score = 71.3 bits (167), Expect = 3e-12
Identities = 39/136 (28%), Positives = 73/136 (53%), Gaps = 2/136 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++G+ ++TQN+D LH KAG++ ++E+HG+ + +C C + ++ +P
Sbjct: 130 KQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYK--------SPIC 181
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPK--CEGPLKPDIVFFGDNVPKYRVEQVRKEV 588
+ P+ + + VEK P C + C G L+P +V+FG+N+ +E+V +E+
Sbjct: 182 PALSGKGAPEPGTQDASIPVEKL--PRCEEAGCGGLLRPHVVWFGENLDPAILEEVDREL 239
Query: 589 TSSDAVFVMGSSLTVY 636
D V+G+S VY
Sbjct: 240 AHCDLCLVVGTSSVVY 255
>AF083110-1|AAD40853.1| 310|Homo sapiens sirtuin type 5 protein.
Length = 310
Score = 71.3 bits (167), Expect = 3e-12
Identities = 39/136 (28%), Positives = 73/136 (53%), Gaps = 2/136 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++G+ ++TQN+D LH KAG++ ++E+HG+ + +C C + ++ +P
Sbjct: 130 KQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYK--------SPIC 181
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPK--CEGPLKPDIVFFGDNVPKYRVEQVRKEV 588
+ P+ + + VEK P C + C G L+P +V+FG+N+ +E+V +E+
Sbjct: 182 PALSGKGAPEPGTQDASIPVEKL--PRCEEAGCGGLLRPHVVWFGENLDPAILEEVDREL 239
Query: 589 TSSDAVFVMGSSLTVY 636
D V+G+S VY
Sbjct: 240 AHCDLCLVVGTSSVVY 255
>BC012499-1|AAH12499.1| 555|Homo sapiens SIRT1 protein protein.
Length = 555
Score = 61.3 bits (142), Expect = 3e-09
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 2/135 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++GK+ TQN+D L AG +++I+ HG+ CL C Y++D ++ L
Sbjct: 143 KEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGAL------- 195
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPKCE--GPLKPDIVFFGDNVPKYRVEQVRKEV 588
FS + P R P CP E +KP+IVFFG+N+P+ ++ +
Sbjct: 196 ---FSQVVP--------------RCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDK 238
Query: 589 TSSDAVFVMGSSLTV 633
D + V+GSSL V
Sbjct: 239 DEVDLLIVIGSSLKV 253
>DQ278604-1|ABB72675.1| 747|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 1 (S. cerevisiae)
protein.
Length = 747
Score = 58.4 bits (135), Expect = 2e-08
Identities = 40/135 (29%), Positives = 66/135 (48%), Gaps = 2/135 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++GK+ TQN+D L AG +++I+ HG+ CL C Y++D ++ +
Sbjct: 335 KEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDI------- 387
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPKCE--GPLKPDIVFFGDNVPKYRVEQVRKEV 588
F+ + P R P CP E +KP+IVFFG+N+P+ ++ +
Sbjct: 388 ---FNQVVP--------------RCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDK 430
Query: 589 TSSDAVFVMGSSLTV 633
D + V+GSSL V
Sbjct: 431 DEVDLLIVIGSSLKV 445
>AL133551-8|CAI16036.1| 747|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 1 (S. cerevisiae)
protein.
Length = 747
Score = 58.4 bits (135), Expect = 2e-08
Identities = 40/135 (29%), Positives = 66/135 (48%), Gaps = 2/135 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++GK+ TQN+D L AG +++I+ HG+ CL C Y++D ++ +
Sbjct: 335 KEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDI------- 387
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPKCE--GPLKPDIVFFGDNVPKYRVEQVRKEV 588
F+ + P R P CP E +KP+IVFFG+N+P+ ++ +
Sbjct: 388 ---FNQVVP--------------RCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDK 430
Query: 589 TSSDAVFVMGSSLTV 633
D + V+GSSL V
Sbjct: 431 DEVDLLIVIGSSLKV 445
>AF235040-1|AAG38486.1| 747|Homo sapiens SIR2alpha protein protein.
Length = 747
Score = 58.4 bits (135), Expect = 2e-08
Identities = 40/135 (29%), Positives = 66/135 (48%), Gaps = 2/135 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++GK+ TQN+D L AG +++I+ HG+ CL C Y++D ++ +
Sbjct: 335 KEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDI------- 387
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPKCE--GPLKPDIVFFGDNVPKYRVEQVRKEV 588
F+ + P R P CP E +KP+IVFFG+N+P+ ++ +
Sbjct: 388 ---FNQVVP--------------RCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDK 430
Query: 589 TSSDAVFVMGSSLTV 633
D + V+GSSL V
Sbjct: 431 DEVDLLIVIGSSLKV 445
>AF083106-1|AAD40849.2| 747|Homo sapiens sirtuin type 1 protein.
Length = 747
Score = 58.4 bits (135), Expect = 2e-08
Identities = 40/135 (29%), Positives = 66/135 (48%), Gaps = 2/135 (1%)
Frame = +1
Query: 235 RKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDM 414
++GK+ TQN+D L AG +++I+ HG+ CL C Y++D ++ +
Sbjct: 335 KEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDI------- 387
Query: 415 ESSFSMIRPDGDVELSREQVEKFRAPLCPKCE--GPLKPDIVFFGDNVPKYRVEQVRKEV 588
F+ + P R P CP E +KP+IVFFG+N+P+ ++ +
Sbjct: 388 ---FNQVVP--------------RCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDK 430
Query: 589 TSSDAVFVMGSSLTV 633
D + V+GSSL V
Sbjct: 431 DEVDLLIVIGSSLKV 445
>AC006930-1|AAD15478.1| 377|Homo sapiens R33423_1 protein.
Length = 377
Score = 57.2 bits (132), Expect = 5e-08
Identities = 44/182 (24%), Positives = 80/182 (43%), Gaps = 2/182 (1%)
Frame = +1
Query: 172 YSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 345
+ T E T +L R G + +V+QNVD LH ++G +K+ ELHG ++ +C
Sbjct: 82 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
Query: 346 LKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKP 525
KC + R + + + + R E E +P P C G L+
Sbjct: 142 AKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGGCEAPED--SPQLPHCRGELRD 199
Query: 526 DIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGP 705
I+ + D++P + + ++D +G+SL + S + L + + I+N+ P
Sbjct: 200 TILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQP 259
Query: 706 TR 711
T+
Sbjct: 260 TK 261
>BC003547-1|AAH03547.1| 352|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 2 (S. cerevisiae)
protein.
Length = 352
Score = 51.2 bits (117), Expect = 4e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + TQN+D L AG E+ ++E HGT Y C+ RHE
Sbjct: 121 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYP--------- 168
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ +E++ P C C+ +KPDIVFFG+++P ++ +
Sbjct: 169 -------------LSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFL 215
Query: 592 SSDAVFVMGSSLTVYSSYRIILQA 663
D + VMG+SL V +I +A
Sbjct: 216 KVDLLLVMGTSLQVQPFASLISKA 239
>BC003012-1|AAH03012.1| 352|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 2 (S. cerevisiae)
protein.
Length = 352
Score = 51.2 bits (117), Expect = 4e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + TQN+D L AG E+ ++E HGT Y C+ RHE
Sbjct: 121 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYP--------- 168
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ +E++ P C C+ +KPDIVFFG+++P ++ +
Sbjct: 169 -------------LSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFL 215
Query: 592 SSDAVFVMGSSLTVYSSYRIILQA 663
D + VMG+SL V +I +A
Sbjct: 216 KVDLLLVMGTSLQVQPFASLISKA 239
>AY030277-1|AAK51133.1| 352|Homo sapiens SIRT2 protein.
Length = 352
Score = 51.2 bits (117), Expect = 4e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + TQN+D L AG E+ ++E HGT Y C+ RHE
Sbjct: 121 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYP--------- 168
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ +E++ P C C+ +KPDIVFFG+++P ++ +
Sbjct: 169 -------------LSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFL 215
Query: 592 SSDAVFVMGSSLTVYSSYRIILQA 663
D + VMG+SL V +I +A
Sbjct: 216 KVDLLLVMGTSLQVQPFASLISKA 239
>AF095714-1|AAD45971.1| 352|Homo sapiens silencing information
regulator 2-like protein protein.
Length = 352
Score = 51.2 bits (117), Expect = 4e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + TQN+D L AG E+ ++E HGT Y C+ RHE
Sbjct: 121 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYP--------- 168
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ +E++ P C C+ +KPDIVFFG+++P ++ +
Sbjct: 169 -------------LSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFL 215
Query: 592 SSDAVFVMGSSLTVYSSYRIILQA 663
D + VMG+SL V +I +A
Sbjct: 216 KVDLLLVMGTSLQVQPFASLISKA 239
>AF083107-1|AAD40850.2| 389|Homo sapiens sirtuin type 2 protein.
Length = 389
Score = 51.2 bits (117), Expect = 4e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + TQN+D L AG E+ ++E HGT Y C+ RHE
Sbjct: 158 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYP--------- 205
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ +E++ P C C+ +KPDIVFFG+++P ++ +
Sbjct: 206 -------------LSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFL 252
Query: 592 SSDAVFVMGSSLTVYSSYRIILQA 663
D + VMG+SL V +I +A
Sbjct: 253 KVDLLLVMGTSLQVQPFASLISKA 276
>BC001042-1|AAH01042.1| 399|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 3 (S. cerevisiae)
protein.
Length = 399
Score = 49.2 bits (112), Expect = 1e-05
Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + + TQN+D L +G + K++E HGT C C
Sbjct: 219 KGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVC------------------- 259
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ F P D+ R V R P CP C G +KPDIVFFG+ +P+ + V +
Sbjct: 260 -QRPF----PGEDI---RADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHV-VDFP 310
Query: 592 SSDAVFVMGSSLTV 633
+D + ++G+SL V
Sbjct: 311 MADLLLILGTSLEV 324
>AF131800-1|AAD20046.1| 254|Homo sapiens Similar to rat 5E5 antigen
protein.
Length = 254
Score = 49.2 bits (112), Expect = 1e-05
Identities = 38/132 (28%), Positives = 58/132 (43%), Gaps = 2/132 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + TQN+D L AG E+ ++E HGT Y C+ RHE
Sbjct: 141 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYP--------- 188
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ +E++ P C C+ +KPDIVFFG+++P ++ +
Sbjct: 189 -------------LSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFL 235
Query: 592 SSDAVFVMGSSL 627
D + VMG+SL
Sbjct: 236 KVDLLLVMGTSL 247
>AF083108-1|AAD40851.1| 399|Homo sapiens sirtuin type 3 protein.
Length = 399
Score = 49.2 bits (112), Expect = 1e-05
Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + + TQN+D L +G + K++E HGT C C
Sbjct: 219 KGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVC------------------- 259
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
+ F P D+ R V R P CP C G +KPDIVFFG+ +P+ + V +
Sbjct: 260 -QRPF----PGEDI---RADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHV-VDFP 310
Query: 592 SSDAVFVMGSSLTV 633
+D + ++G+SL V
Sbjct: 311 MADLLLILGTSLEV 324
>AJ505014-1|CAD43717.1| 369|Homo sapiens sirtuin type 2 protein.
Length = 369
Score = 48.0 bits (109), Expect = 3e-05
Identities = 44/144 (30%), Positives = 64/144 (44%), Gaps = 2/144 (1%)
Frame = +1
Query: 238 KGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPD 411
KG + TQN+D L AG E+ ++E HGT Y C+ RHE +
Sbjct: 138 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYPLSWMK---- 190
Query: 412 MESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVT 591
E FS +V L C C+ +KPDIVFFG+++P ++ +
Sbjct: 191 -EKIFS------EVTLK-----------CEDCQSLVKPDIVFFGESLPARFFSCMQSDFL 232
Query: 592 SSDAVFVMGSSLTVYSSYRIILQA 663
D + VMG+SL V +I +A
Sbjct: 233 KVDLLLVMGTSLQVQPFASLISKA 256
>CR457200-1|CAG33481.1| 355|Homo sapiens SIRT6 protein.
Length = 355
Score = 45.6 bits (103), Expect = 2e-04
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 2/182 (1%)
Frame = +1
Query: 172 YSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 345
+ T E T +L R G + +V+QNVD LH ++G +K+ ELHG ++ +C
Sbjct: 82 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
Query: 346 LKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKP 525
KC + R D ++ G + + + RA C G L+
Sbjct: 142 AKCKTQYVR------------DTVVGTMGLKATGRL-CTVAKARGLRA-----CRGELRD 183
Query: 526 DIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGP 705
I+ + D++P + + ++D +G+SL + S + L + + I+N+ P
Sbjct: 184 TILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQP 243
Query: 706 TR 711
T+
Sbjct: 244 TK 245
>BC005026-1|AAH05026.1| 355|Homo sapiens sirtuin (silent mating
type information regulation 2 homolog) 6 (S. cerevisiae)
protein.
Length = 355
Score = 45.6 bits (103), Expect = 2e-04
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 2/182 (1%)
Frame = +1
Query: 172 YSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 345
+ T E T +L R G + +V+QNVD LH ++G +K+ ELHG ++ +C
Sbjct: 82 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
Query: 346 LKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKP 525
KC + R D ++ G + + + RA C G L+
Sbjct: 142 AKCKTQYVR------------DTVVGTMGLKATGRL-CTVAKARGLRA-----CRGELRD 183
Query: 526 DIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGP 705
I+ + D++P + + ++D +G+SL + S + L + + I+N+ P
Sbjct: 184 TILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQP 243
Query: 706 TR 711
T+
Sbjct: 244 TK 245
>AK074992-1|BAC11340.1| 134|Homo sapiens protein ( Homo sapiens
cDNA FLJ90511 fis, clone NT2RP3004321. ).
Length = 134
Score = 45.6 bits (103), Expect = 2e-04
Identities = 21/50 (42%), Positives = 32/50 (64%)
Frame = +1
Query: 484 RAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTV 633
R P CP C G +KPDIVFFG+ +P+ + V + +D + ++G+SL V
Sbjct: 52 RVPRCPVCTGVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILGTSLEV 100
>AK074810-1|BAC11222.1| 355|Homo sapiens protein ( Homo sapiens
cDNA FLJ90329 fis, clone NT2RP2001948, weakly similar to
HST2 PROTEIN. ).
Length = 355
Score = 45.6 bits (103), Expect = 2e-04
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 2/182 (1%)
Frame = +1
Query: 172 YSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 345
+ T E T +L R G + +V+QNVD LH ++G +K+ ELHG ++ +C
Sbjct: 82 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
Query: 346 LKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKP 525
KC + R D ++ G + + + RA C G L+
Sbjct: 142 AKCKTQYVR------------DTVVGTMGLKATGRL-CTVAKARGLRA-----CRGELRD 183
Query: 526 DIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGP 705
I+ + D++P + + ++D +G+SL + S + L + + I+N+ P
Sbjct: 184 TILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQP 243
Query: 706 TR 711
T+
Sbjct: 244 TK 245
>AF233396-1|AAF43432.1| 355|Homo sapiens sir2-related protein type
6 protein.
Length = 355
Score = 45.6 bits (103), Expect = 2e-04
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 2/182 (1%)
Frame = +1
Query: 172 YSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 345
+ T E T +L R G + +V+QNVD LH ++G +K+ ELHG ++ +C
Sbjct: 82 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
Query: 346 LKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVELSREQVEKFRAPLCPKCEGPLKP 525
KC + R D ++ G + + + RA C G L+
Sbjct: 142 AKCKTQYVR------------DTVVGTMGLKATGRL-CTVAKARGLRA-----CRGELRD 183
Query: 526 DIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTVYSSYRIILQARDEHKNIAILNIGP 705
I+ + D++P + + ++D +G+SL + S + L + + I+N+ P
Sbjct: 184 TILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQP 243
Query: 706 TR 711
T+
Sbjct: 244 TK 245
>AF160214-1|AAF67015.1| 373|Homo sapiens silent information
regulator 2 homolog protein.
Length = 373
Score = 45.6 bits (103), Expect = 2e-04
Identities = 22/67 (32%), Positives = 37/67 (55%)
Frame = +1
Query: 463 REQVEKFRAPLCPKCEGPLKPDIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTVYSS 642
+E++ P C C+ +KPDIVFFG+++P ++ + D + VMG+SL V
Sbjct: 194 KEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPF 253
Query: 643 YRIILQA 663
+I +A
Sbjct: 254 ASLISKA 260
>BC028220-1|AAH28220.1| 328|Homo sapiens SIRT6 protein protein.
Length = 328
Score = 40.7 bits (91), Expect = 0.005
Identities = 22/63 (34%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Frame = +1
Query: 172 YSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 345
+ T E T +L R G + +V+QNVD LH ++G +K+ ELHG ++ +C
Sbjct: 82 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
Query: 346 LKC 354
KC
Sbjct: 142 AKC 144
>BC004218-1|AAH04218.1| 256|Homo sapiens SIRT6 protein protein.
Length = 256
Score = 40.7 bits (91), Expect = 0.005
Identities = 22/63 (34%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Frame = +1
Query: 172 YSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 345
+ T E T +L R G + +V+QNVD LH ++G +K+ ELHG ++ +C
Sbjct: 10 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 69
Query: 346 LKC 354
KC
Sbjct: 70 AKC 72
>AL137276-1|CAB70674.1| 118|Homo sapiens hypothetical protein
protein.
Length = 118
Score = 35.9 bits (79), Expect = 0.14
Identities = 17/43 (39%), Positives = 28/43 (65%)
Frame = +1
Query: 505 CEGPLKPDIVFFGDNVPKYRVEQVRKEVTSSDAVFVMGSSLTV 633
C G +KPDIVFFG+ +P+ + V + +D + ++G+SL V
Sbjct: 2 CTGVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILGTSLEV 43
>AY960861-1|AAX57561.1| 117|Homo sapiens anti-oxLDL immunoglobulin
heavy chain variable region protein.
Length = 117
Score = 29.9 bits (64), Expect = 9.4
Identities = 20/77 (25%), Positives = 37/77 (48%)
Frame = +1
Query: 109 GKKLYRLAEIQLCATERHTSLYSRTREGILKESTTSSLFINIRKGKVTSIVTQNVDRLHH 288
GK L +A I+ +E++ + R I +++ +SLF+ + +V R+H+
Sbjct: 37 GKGLEWVANIKQDESEKYYVDSVKGRFTISRDNAKNSLFLQMNSLRVEDTAVYYCARIHY 96
Query: 289 KAGSEKVIELHGTSYLV 339
+GS I+ G LV
Sbjct: 97 GSGSSPHIDYWGQGTLV 113
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 109,691,086
Number of Sequences: 237096
Number of extensions: 2522480
Number of successful extensions: 13328
Number of sequences better than 10.0: 34
Number of HSP's better than 10.0 without gapping: 13076
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 13322
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8287202872
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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