Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NV120839.seq
(692 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 114 2e-24
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 110 3e-23
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 110 3e-23
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 109 5e-23
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 105 8e-22
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 99 9e-20
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 96 6e-19
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 87 3e-16
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 87 5e-16
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 86 7e-16
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 85 2e-15
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 84 3e-15
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 84 3e-15
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 84 4e-15
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 83 8e-15
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 81 2e-14
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 81 3e-14
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 81 3e-14
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 81 3e-14
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 80 4e-14
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 80 4e-14
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 80 6e-14
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 80 6e-14
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 79 1e-13
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 79 1e-13
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 78 2e-13
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 78 2e-13
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 78 2e-13
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 78 2e-13
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 78 2e-13
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 77 4e-13
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 77 5e-13
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 75 1e-12
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 75 1e-12
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 75 1e-12
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 73 9e-12
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 72 2e-11
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 72 2e-11
UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunction... 70 6e-11
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 70 6e-11
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 69 1e-10
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 69 1e-10
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 69 1e-10
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 67 3e-10
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 67 4e-10
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 67 4e-10
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 66 6e-10
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 66 6e-10
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 66 8e-10
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 66 1e-09
UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate dehydrogenase... 65 1e-09
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 65 2e-09
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 65 2e-09
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 64 3e-09
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 64 4e-09
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 63 5e-09
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 63 7e-09
UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-pro... 62 9e-09
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 62 1e-08
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 62 1e-08
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 62 2e-08
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 62 2e-08
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 61 2e-08
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 61 2e-08
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 61 2e-08
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 61 3e-08
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 60 4e-08
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 60 4e-08
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 60 4e-08
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 60 5e-08
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 59 9e-08
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 58 2e-07
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 57 4e-07
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 57 4e-07
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 57 5e-07
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 56 6e-07
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 56 8e-07
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 56 8e-07
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 56 8e-07
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 56 1e-06
UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes: Me... 56 1e-06
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 54 3e-06
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 54 4e-06
UniRef50_A4M873 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 54 4e-06
UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunction... 53 6e-06
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 52 1e-05
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 52 2e-05
UniRef50_A6LP88 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 51 2e-05
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 48 2e-04
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 48 2e-04
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 47 5e-04
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 46 7e-04
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 46 9e-04
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 46 0.001
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 44 0.004
UniRef50_UPI000023D48A Cluster: hypothetical protein FG10624.1; ... 42 0.014
UniRef50_Q02046 Cluster: Methylenetetrahydrofolate dehydrogenase... 42 0.019
UniRef50_A6RXY2 Cluster: Putative uncharacterized protein; n=1; ... 39 0.13
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 38 0.23
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 36 0.71
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 36 0.94
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 35 2.2
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 35 2.2
UniRef50_UPI000051DDF1 Cluster: ACETYLCHOLINE-BINDING PROTEIN; n... 34 2.9
UniRef50_A6QZK7 Cluster: Putative uncharacterized protein; n=1; ... 34 2.9
UniRef50_Q8ZSG1 Cluster: Alr7549 protein; n=3; Nostocaceae|Rep: ... 34 3.8
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 34 3.8
UniRef50_A0VHR0 Cluster: Polar amino acid ABC transporter, inner... 33 5.0
UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate deh... 33 5.0
UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase... 33 5.0
UniRef50_O74539 Cluster: Peroxide stress-activated histidine kin... 33 5.0
UniRef50_Q18E84 Cluster: ATP-dependent DNA helicase; n=1; Haloqu... 33 6.6
UniRef50_P76339 Cluster: Putative sensor-like histidine kinase y... 33 6.6
UniRef50_Q8YFR7 Cluster: Diguanylate cyclase/phosphodiesterase d... 33 8.8
UniRef50_A5MC89 Cluster: Putative uncharacterized protein; n=1; ... 33 8.8
UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin... 33 8.8
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 114 bits (274), Expect = 2e-24
Identities = 50/81 (61%), Positives = 68/81 (83%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
+DITEEQLL I+ LN+D+SVDGILVQLPVP INER+VC++++ +KD+DGF+ NIGRL
Sbjct: 103 ADITEEQLLKRIEELNQDDSVDGILVQLPVPGHINERKVCNSVSCDKDVDGFNERNIGRL 162
Query: 446 CVDLPTIVPATALAVVEMLKR 508
C+D+ T++P T L V E++KR
Sbjct: 163 CLDMNTLIPCTPLGVQELIKR 183
Score = 74.1 bits (174), Expect = 3e-12
Identities = 33/67 (49%), Positives = 52/67 (77%), Gaps = 1/67 (1%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLG-NRAPTIRCIIVGDDPASHTYVRNKVEAAKF 233
MA+++DGK +A +I+ EL+++I +W+ G NRAP + I++G+DPAS+TYV NK++AA
Sbjct: 32 MAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAAD 91
Query: 234 VGIDALT 254
VGI + T
Sbjct: 92 VGITSKT 98
Score = 66.9 bits (156), Expect = 4e-10
Identities = 29/44 (65%), Positives = 38/44 (86%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKRQ 668
VV+GRSKNVGMPIAM+LH+D R+++ MDATVT+CHR+TP +
Sbjct: 194 VVVGRSKNVGMPIAMLLHADGRNDT-CAMDATVTMCHRFTPPEE 236
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 110 bits (265), Expect = 3e-23
Identities = 51/93 (54%), Positives = 69/93 (74%)
Frame = +2
Query: 230 ICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKD 409
I G + R S +++E+LL I +N D V G+LVQLP+P+ INER VC+AIAPEKD
Sbjct: 64 ILGISSDTVVRPSSVSQEELLELIDKMNRDWRVSGLLVQLPLPEHINERAVCNAIAPEKD 123
Query: 410 IDGFHIINIGRLCVDLPTIVPATALAVVEMLKR 508
+DGFHI+NIG+LC+D ++VPAT AV E++KR
Sbjct: 124 VDGFHIVNIGKLCLDQRSMVPATPAAVWEIIKR 156
Score = 60.9 bits (141), Expect = 3e-08
Identities = 26/66 (39%), Positives = 44/66 (66%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++ G LA +I++E+++ + + V GN P + ++VG+DPAS TYV+NK AA +G
Sbjct: 7 AVVISGTELARQIQREIQRDVEELVAQGNMRPHLGVVLVGEDPASRTYVKNKTRAASILG 66
Query: 240 IDALTL 257
I + T+
Sbjct: 67 ISSDTV 72
Score = 46.8 bits (106), Expect = 5e-04
Identities = 21/40 (52%), Positives = 27/40 (67%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
+V GRSKNVGMPIAM+LH+D++HE G T +T
Sbjct: 167 LVAGRSKNVGMPIAMLLHTDRKHERSGGRHHTQARARAHT 206
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 110 bits (265), Expect = 3e-23
Identities = 46/93 (49%), Positives = 73/93 (78%)
Frame = +2
Query: 230 ICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKD 409
+ G I + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD
Sbjct: 94 VVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKD 153
Query: 410 IDGFHIINIGRLCVDLPTIVPATALAVVEMLKR 508
+DGFH+IN+GR+C+D +++PAT V E++KR
Sbjct: 154 VDGFHVINVGRMCLDQYSMLPATPWGVWEIIKR 186
Score = 72.9 bits (171), Expect = 7e-12
Identities = 30/66 (45%), Positives = 49/66 (74%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++ G+ LA +IK+E++Q++ +WV GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96
Query: 240 IDALTL 257
I++ T+
Sbjct: 97 INSETI 102
Score = 67.7 bits (158), Expect = 3e-10
Identities = 34/47 (72%), Positives = 36/47 (76%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKRQTWK 677
VV GRSKNVGMPIAM+LH+D HE G DATVTI HRYTPK Q K
Sbjct: 197 VVAGRSKNVGMPIAMLLHTDGAHERP-GGDATVTISHRYTPKEQLKK 242
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 109 bits (263), Expect = 5e-23
Identities = 46/85 (54%), Positives = 68/85 (80%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
I + SDI+EE+LL I LN D+ VDG+LVQLP+P+ I+ER +C+A+AP KD+DGFH++N
Sbjct: 95 ILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPLPEHIDERTICNAVAPTKDVDGFHVVN 154
Query: 434 IGRLCVDLPTIVPATALAVVEMLKR 508
+GR+C+D +++PAT V E++KR
Sbjct: 155 VGRMCLDQSSMLPATPWGVWEIIKR 179
Score = 69.7 bits (163), Expect = 6e-11
Identities = 34/44 (77%), Positives = 36/44 (81%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKRQ 668
VV GRSKNVGMPIAM+LH+D RHE G DATVTI HRYTPK Q
Sbjct: 190 VVAGRSKNVGMPIAMLLHTDGRHERP-GGDATVTISHRYTPKEQ 232
Score = 66.5 bits (155), Expect = 6e-10
Identities = 28/66 (42%), Positives = 45/66 (68%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++ G+ LA +I++E + + +WV G+R P + ++VGDDPASH+YV NK AA +G
Sbjct: 30 AVVISGRKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAAADIG 89
Query: 240 IDALTL 257
I + T+
Sbjct: 90 ISSETI 95
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 105 bits (253), Expect = 8e-22
Identities = 48/94 (51%), Positives = 66/94 (70%)
Frame = +2
Query: 227 KICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEK 406
K G + + IT+E+LL E+Q LN+D +VDG+LVQLPVP+ I+ER VC A+ P K
Sbjct: 84 KTVGIESETLRFEDSITQEELLHEVQKLNDDPTVDGLLVQLPVPEHISEREVCQAVTPTK 143
Query: 407 DIDGFHIINIGRLCVDLPTIVPATALAVVEMLKR 508
D+DGFH+ NIG L ++ I+PATAL V E++ R
Sbjct: 144 DVDGFHLSNIGNLALNNKGIIPATALGVKELIVR 177
Score = 62.5 bits (145), Expect = 9e-09
Identities = 28/42 (66%), Positives = 34/42 (80%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPK 662
VVIGRSK+VG PIA++LHSD E+ G+D T TICHRYTP+
Sbjct: 188 VVIGRSKHVGFPIALLLHSDGNGETA-GLDMTTTICHRYTPR 228
Score = 58.0 bits (134), Expect = 2e-07
Identities = 28/71 (39%), Positives = 46/71 (64%)
Frame = +3
Query: 45 NFIIMARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEA 224
N + A I+DG +A ++ +E+K ++ + G + P + I+VG++PAS YV KV+A
Sbjct: 23 NRVCDAAIIDGNGVADQVLEEVKAEVDEMTRNGEKRPKLIAILVGNNPASKAYVGRKVKA 82
Query: 225 AKFVGIDALTL 257
AK VGI++ TL
Sbjct: 83 AKTVGIESETL 93
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 99.1 bits (236), Expect = 9e-20
Identities = 42/85 (49%), Positives = 63/85 (74%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
I + D+TEE+LL+ + LN+D +VDG +VQLP+P I+E+++ +A+ P KD+DGFH IN
Sbjct: 70 IRYEDDVTEEELLACVHRLNQDPTVDGFIVQLPLPKHIDEQKIIEAVDPRKDVDGFHPIN 129
Query: 434 IGRLCVDLPTIVPATALAVVEMLKR 508
+GRL + LP V AT +VE+L+R
Sbjct: 130 VGRLSIGLPGFVSATPKGIVELLRR 154
Score = 48.4 bits (110), Expect = 2e-04
Identities = 22/59 (37%), Positives = 38/59 (64%)
Frame = +3
Query: 63 RILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
++LDGK ++ EIK+E+ + + + G R P + ++VG D S TY+ +KV+A + VG
Sbjct: 6 KLLDGKKISGEIKQEIAAVVNELLEKGGRRPHLAGVLVGHDGGSETYMASKVKACEEVG 64
Score = 35.1 bits (77), Expect = 1.6
Identities = 19/41 (46%), Positives = 26/41 (63%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTP 659
VV+GRS VG P++ +L ++ E G D T+TICH TP
Sbjct: 165 VVLGRSNIVGKPVSQLLL--QKGEPG---DCTITICHSRTP 200
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 96.3 bits (229), Expect = 6e-19
Identities = 43/85 (50%), Positives = 63/85 (74%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
I+ D +++ +++EI NLN+D +VDGILVQLP+ +NE+ VC AI P KD+DGFH+ N
Sbjct: 175 IHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKHMNEQEVCQAIIPSKDVDGFHLEN 234
Query: 434 IGRLCVDLPTIVPATALAVVEMLKR 508
+G L ++ I+PATALAV E++ R
Sbjct: 235 LGNLALNRNGIIPATALAVKELIIR 259
Score = 60.9 bits (141), Expect = 3e-08
Identities = 31/82 (37%), Positives = 49/82 (59%)
Frame = +3
Query: 12 LSTWFENSKNNNFIIMARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPA 191
L T+ NS ++ A I+DGK +A +I+ ELK + W+ + P + I VG++PA
Sbjct: 96 LRTYCRNSNSSRQ--NAIIIDGKKIANKIQNELKITVDNWINDNKKRPKLVAIKVGNNPA 153
Query: 192 SHTYVRNKVEAAKFVGIDALTL 257
S YV K++AA F+GI+ T+
Sbjct: 154 SKIYVEKKIKAANFIGIENYTI 175
Score = 58.8 bits (136), Expect = 1e-07
Identities = 25/47 (53%), Positives = 35/47 (74%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKRQTWK 677
VV+GRSK+VG+PIA++LH D + +G +D T TICHR+TP + K
Sbjct: 270 VVVGRSKHVGLPIALLLHGDSKDRTG-ALDMTTTICHRHTPHTELEK 315
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 87.4 bits (207), Expect = 3e-16
Identities = 43/107 (40%), Positives = 68/107 (63%)
Frame = +2
Query: 185 PSEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDT 364
PSE +++ + + S + G + I E +LL++I+ +NED + DG++VQLP+P
Sbjct: 44 PSESYVKSKIATSG-LAGFESTLLRFPETIRESELLAKIKEVNEDPTTDGLIVQLPLPKH 102
Query: 365 INERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLK 505
IN++ V +AIAPEKDIDGFH N GR+ + PATA + ++L+
Sbjct: 103 INQQHVINAIAPEKDIDGFHPANFGRMTLGQKAFRPATAYGICKLLQ 149
Score = 44.4 bits (100), Expect = 0.003
Identities = 20/64 (31%), Positives = 36/64 (56%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 245
+LDGK A + E+ +K+A + G R P + I+VG+ S +YV++K+ + G +
Sbjct: 3 LLDGKKCAESLVAEIARKVAGYTESGLRTPHMTIILVGEHAPSESYVKSKIATSGLAGFE 62
Query: 246 ALTL 257
+ L
Sbjct: 63 STLL 66
Score = 34.3 bits (75), Expect = 2.9
Identities = 21/42 (50%), Positives = 28/42 (66%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPK 662
VVIGRS VG PI++ML +D + G +ATVT+ H TP+
Sbjct: 161 VVIGRSNIVGKPISIMLSND--FDIG---NATVTLTHIETPR 197
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 86.6 bits (205), Expect = 5e-16
Identities = 43/99 (43%), Positives = 63/99 (63%), Gaps = 4/99 (4%)
Frame = +2
Query: 224 RKICGHRCININRDSDI----TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDA 391
RK+C I+R D+ TE +LL+ I LN D ++DGILVQLP+P+ I+ +V +
Sbjct: 55 RKVCEEVGF-ISRSYDLPITTTESELLALIDQLNADQAIDGILVQLPLPEGIDNTKVIER 113
Query: 392 IAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKR 508
IAP+KD+DGFH N+GRLC P + T ++ +L+R
Sbjct: 114 IAPDKDVDGFHPYNVGRLCQRAPLLRACTPRGIITLLER 152
Score = 56.8 bits (131), Expect = 5e-07
Identities = 24/60 (40%), Positives = 40/60 (66%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A+I+DGK +A ++K E+ ++ Q + G RAP + ++VGD+PAS YV +K + + VG
Sbjct: 3 AKIIDGKTIAQQVKDEVAARVTQRLAEGKRAPGLAVVLVGDNPASQIYVTSKRKVCEEVG 62
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 86.2 bits (204), Expect = 7e-16
Identities = 39/90 (43%), Positives = 56/90 (62%)
Frame = +2
Query: 236 GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 415
G R + D+D++E++LL++I LN + V GILVQLP+P INE RV + I P+KD+D
Sbjct: 69 GIRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVD 128
Query: 416 GFHIINIGRLCVDLPTIVPATALAVVEMLK 505
GFH N+G L + P T + +LK
Sbjct: 129 GFHSENVGGLSQGRDVLTPCTPTGCIRLLK 158
Score = 61.3 bits (142), Expect = 2e-08
Identities = 28/63 (44%), Positives = 44/63 (69%)
Frame = +3
Query: 63 RILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
+I+DGKA+A + +E+K ++ ++ G P + ++VG+DPAS YVRNKV+ A FVGI
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGI 70
Query: 243 DAL 251
+L
Sbjct: 71 RSL 73
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 85.0 bits (201), Expect = 2e-15
Identities = 36/79 (45%), Positives = 57/79 (72%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
+ITE +LLS I++ N D ++ G+LVQLP+P I+ + + +AI P KD+DGFH +NIG+LC
Sbjct: 76 NITEAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLC 135
Query: 449 VDLPTIVPATALAVVEMLK 505
+ +PAT + V+ +L+
Sbjct: 136 TQKESFLPATPMGVMRLLE 154
Score = 56.4 bits (130), Expect = 6e-07
Identities = 28/60 (46%), Positives = 40/60 (66%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 245
+LDG+ALA I+K+LK KI ++ P + I+VG DPAS TYV K++A + VG+D
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMD 67
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 84.2 bits (199), Expect = 3e-15
Identities = 42/79 (53%), Positives = 51/79 (64%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
D+ EE LL I LN D VDGILVQLP+P I +RV +AI P KD+DGFH +N+GRL
Sbjct: 69 DLPEEALLERIAALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFHPLNVGRLW 128
Query: 449 VDLPTIVPATALAVVEMLK 505
+ P T L VV +LK
Sbjct: 129 SGGKGLFPCTPLGVVRLLK 147
Score = 34.7 bits (76), Expect = 2.2
Identities = 19/60 (31%), Positives = 35/60 (58%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A++L G A + +E++ ++ + P++R I +G+DPAS YVR K + A+ +G
Sbjct: 3 AQVLSGHEAAEAVYEEIRARLRSL----SFTPSLRVIRLGEDPASVAYVRLKDKRARALG 58
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 84.2 bits (199), Expect = 3e-15
Identities = 36/84 (42%), Positives = 57/84 (67%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
I +I++++LL I N D+SV GILVQLP+PD ++E+++ AI+P KD+DGFH IN
Sbjct: 66 IELPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQMDEQKIIHAISPAKDVDGFHPIN 125
Query: 434 IGRLCVDLPTIVPATALAVVEMLK 505
+G++ T +P T ++ ML+
Sbjct: 126 VGKMMTGEDTFIPCTPYGILTMLR 149
Score = 47.6 bits (108), Expect = 3e-04
Identities = 24/64 (37%), Positives = 41/64 (64%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
MA +L+GK L+ E+K+++K ++ + G P + I+VGD+PAS +YV+ K +A
Sbjct: 1 MATLLNGKELSEELKQKMKIEVDELKEKG-LTPHLTVILVGDNPASKSYVKGKEKACAVT 59
Query: 237 GIDA 248
GI +
Sbjct: 60 GISS 63
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 83.8 bits (198), Expect = 4e-15
Identities = 42/80 (52%), Positives = 56/80 (70%), Gaps = 2/80 (2%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV- 451
TEE++L+ + N+D +V GILVQLP+P+ INE+RV DAI+ EKD+DGFH NIG L +
Sbjct: 134 TEEEVLAVVAKFNDDPNVHGILVQLPLPEHINEKRVLDAISLEKDVDGFHPNNIGELAMR 193
Query: 452 -DLPTIVPATALAVVEMLKR 508
PT V T +E+LKR
Sbjct: 194 GRSPTYVSCTPKGCLELLKR 213
Score = 46.0 bits (104), Expect = 9e-04
Identities = 23/63 (36%), Positives = 38/63 (60%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++DGK +A I+ ELK ++ + N P + ++VG+ S TYVR+K +A VG
Sbjct: 62 AALIDGKKIAETIRGELKVEVDELRAQYNTVPGLAVVLVGERKDSQTYVRSKKKACDEVG 121
Query: 240 IDA 248
I++
Sbjct: 122 INS 124
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 82.6 bits (195), Expect = 8e-15
Identities = 38/75 (50%), Positives = 50/75 (66%)
Frame = +2
Query: 284 QLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT 463
Q+L I LNED V GIL+QLP+P ++ RVC A+APEKD+DGFH +N G L + P
Sbjct: 78 QVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDVDGFHPLNCGALFLAQPG 137
Query: 464 IVPATALAVVEMLKR 508
VP T +V +L+R
Sbjct: 138 FVPCTPAGIVHLLRR 152
Score = 42.7 bits (96), Expect = 0.008
Identities = 22/55 (40%), Positives = 29/55 (52%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEA 224
AR++DGK A E L ++ AP + ++VGDDPAS TYV K A
Sbjct: 3 ARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRA 57
Score = 37.1 bits (82), Expect = 0.41
Identities = 19/40 (47%), Positives = 26/40 (65%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
V++GRS VG P+A++L S G DATVT+CH +T
Sbjct: 163 VIVGRSAIVGRPLAVLLASP-------GCDATVTLCHSHT 195
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 81.4 bits (192), Expect = 2e-14
Identities = 39/109 (35%), Positives = 68/109 (62%)
Frame = +2
Query: 185 PSEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDT 364
PS+ ++R ++ + ++ G + I + E+ +L +I+ LN+D S+ GILVQLP+P
Sbjct: 44 PSQIYVRMKEKAANEV-GLKSEVIRYPEAVEEKTVLDKIEELNKDESISGILVQLPLPKH 102
Query: 365 INERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRL 511
I++++V + I P KD+DGFH +N+G L + VP T L M+K++
Sbjct: 103 IDKQKVIETILPGKDVDGFHPMNVGNLSSGYESSVPCTPLGCYLMIKKI 151
Score = 47.6 bits (108), Expect = 3e-04
Identities = 20/59 (33%), Positives = 38/59 (64%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
++DGK +A E++++L+Q++ + N+ P + I++G+ S YVR K +AA VG+
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKIPGLTVILIGEMAPSQIYVRMKEKAANEVGL 61
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 81.0 bits (191), Expect = 3e-14
Identities = 38/93 (40%), Positives = 58/93 (62%), Gaps = 2/93 (2%)
Frame = +2
Query: 236 GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 415
G + + D +EE++L + N+D SV GILVQLP+P ++E+ + +A++ EKD+D
Sbjct: 128 GIKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVD 187
Query: 416 GFHIINIGRLCV--DLPTIVPATALAVVEMLKR 508
GFH +NIGRL + P VP T +E+L R
Sbjct: 188 GFHPLNIGRLAMRGREPLFVPCTPKGCIELLHR 220
Score = 44.8 bits (101), Expect = 0.002
Identities = 24/61 (39%), Positives = 37/61 (60%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++DGKA+A +I+ E+ ++++ P + I+VGD S TYVRNK +A VG
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSVG 128
Query: 240 I 242
I
Sbjct: 129 I 129
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 81.0 bits (191), Expect = 3e-14
Identities = 43/105 (40%), Positives = 61/105 (58%)
Frame = +2
Query: 188 SEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 367
SE ++ +Q ++ G +++ D+D E+L I +LNE V GILVQLPVPD +
Sbjct: 55 SETYVSMKQRDCEEV-GIESVHVEIDADAPAEELYETIDDLNEREDVHGILVQLPVPDHV 113
Query: 368 NERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEML 502
++RRV IAP KD+DGFH N+GRL P T V ++L
Sbjct: 114 DKRRVLRQIAPVKDVDGFHPENVGRLVAGDARFKPCTPHGVQKLL 158
Score = 40.3 bits (90), Expect = 0.044
Identities = 20/63 (31%), Positives = 37/63 (58%)
Frame = +3
Query: 63 RILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
RI+DG+A+A +++ ++ + G P + +++ DDPAS TYV K + VGI
Sbjct: 13 RIIDGEAVAADVRDDVAAHVETLEEEGV-TPGLATVLMSDDPASETYVSMKQRDCEEVGI 71
Query: 243 DAL 251
+++
Sbjct: 72 ESV 74
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 81.0 bits (191), Expect = 3e-14
Identities = 35/81 (43%), Positives = 51/81 (62%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 442
D DI +E+L ++I LN D ++DGIL+QLP+P E AI P KD+DGFH IN G+
Sbjct: 69 DKDIKKEELYNKINELNNDQNIDGILLQLPLPIDFIEEDYLQAITPSKDVDGFHYINQGK 128
Query: 443 LCVDLPTIVPATALAVVEMLK 505
+ T+ P T L ++ +L+
Sbjct: 129 MLQGYDTVYPCTPLGIINLLE 149
Score = 56.0 bits (129), Expect = 8e-07
Identities = 28/59 (47%), Positives = 39/59 (66%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
ILDGK +A K+EL KI+++ G R P + I+VG+DPAS YV +K++ A VGI
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLRKPKLVVIMVGNDPASEVYVSHKIKVANEVGI 61
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 80.2 bits (189), Expect = 4e-14
Identities = 36/78 (46%), Positives = 50/78 (64%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV 451
++E +LL+ I LN D + GILVQLP+P I+ +V +AIAPEKD+DGFH+ N G L
Sbjct: 73 LSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLT 132
Query: 452 DLPTIVPATALAVVEMLK 505
P P T V++M +
Sbjct: 133 GKPLFRPCTPYGVMKMFE 150
Score = 49.6 bits (113), Expect = 7e-05
Identities = 24/64 (37%), Positives = 40/64 (62%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++DG AL+ ++ + ++ A G+R P + I+VGD+PAS YVRNK++A + G
Sbjct: 3 ATLIDGNALSKTLRAQAAERAAALAARGHR-PGLAVILVGDNPASEVYVRNKIKACEDNG 61
Query: 240 IDAL 251
+L
Sbjct: 62 FFSL 65
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 80.2 bits (189), Expect = 4e-14
Identities = 33/79 (41%), Positives = 54/79 (68%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV 451
++ LL +++LN N +DGILVQLP+P ++ +++ A++PEKD+DGFH +N+G L
Sbjct: 73 VSTADLLQLVESLNRRNDIDGILVQLPLPKQVDSKKILLAVSPEKDVDGFHPMNVGYLST 132
Query: 452 DLPTIVPATALAVVEMLKR 508
P +VP T +E+L+R
Sbjct: 133 VRPGLVPCTPAGCMEILRR 151
Score = 53.2 bits (122), Expect = 6e-06
Identities = 26/63 (41%), Positives = 40/63 (63%)
Frame = +3
Query: 54 IMARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKF 233
++A ILDG ++ EIK E+ ++A+ G P + ++VG +PAS YVRNKV+A +
Sbjct: 1 MLATILDGNKISAEIKTEVAAEVAELKAKG-LTPGLAVVLVGHNPASEIYVRNKVKACEM 59
Query: 234 VGI 242
GI
Sbjct: 60 TGI 62
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 79.8 bits (188), Expect = 6e-14
Identities = 35/78 (44%), Positives = 53/78 (67%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD 454
+EE LLS ++ LN D +DGILVQLP+P ++ +V ++I PEKD+DGFH N+GRL
Sbjct: 75 SEEALLSLVEELNNDPQIDGILVQLPLPAGMDTTKVLESIHPEKDVDGFHPYNVGRLAQR 134
Query: 455 LPTIVPATALAVVEMLKR 508
+P + T ++ +L+R
Sbjct: 135 IPKLRSCTPKGIITLLER 152
Score = 46.4 bits (105), Expect = 7e-04
Identities = 21/60 (35%), Positives = 36/60 (60%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A+ +DG ++ ++ E+ ++ V G RAP + ++VG+DPAS YV +K A + VG
Sbjct: 3 AQNIDGTLISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVG 62
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 79.8 bits (188), Expect = 6e-14
Identities = 38/82 (46%), Positives = 54/82 (65%), Gaps = 2/82 (2%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
+ TE +LL+ I+ N D+S+ G+LVQLP+P INE+ + AI P+KD+D FH +NIGRL
Sbjct: 73 ETTEAELLALIEKYNNDDSIHGVLVQLPLPKHINEQNIITAIDPDKDVDAFHPVNIGRLM 132
Query: 449 V--DLPTIVPATALAVVEMLKR 508
+ D +P T + EML R
Sbjct: 133 IGGDDVKFLPCTPAGIQEMLVR 154
Score = 38.3 bits (85), Expect = 0.18
Identities = 19/60 (31%), Positives = 32/60 (53%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A+I+ G + EI E+K + + P + I+VG+ PAS +YV K++ A +G
Sbjct: 3 AKIISGTEIRKEILGEIKDAVTEMKDKYGTVPGLVTILVGESPASMSYVSLKIKTALSLG 62
Score = 37.5 bits (83), Expect = 0.31
Identities = 20/37 (54%), Positives = 25/37 (67%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICH 647
VV+GRS VG PIAMM+ + G+G +ATVTI H
Sbjct: 165 VVVGRSNIVGKPIAMMM-----AQKGIGANATVTIVH 196
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 78.6 bits (185), Expect = 1e-13
Identities = 36/82 (43%), Positives = 55/82 (67%), Gaps = 2/82 (2%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
D +EE++L + N+D SV G+LVQLP+P ++E+ + +A++ EKD+DGFH +NIGRL
Sbjct: 89 DSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLA 148
Query: 449 V--DLPTIVPATALAVVEMLKR 508
+ P VP T +E+L R
Sbjct: 149 MRGREPLFVPCTPKGCIELLHR 170
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 78.6 bits (185), Expect = 1e-13
Identities = 36/80 (45%), Positives = 53/80 (66%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
++ +E +LL+ ++ LN D + GILVQLP+P I+ +V +AI+P KD+DGFH N+GRL
Sbjct: 70 AETSEAELLALVELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDGFHPYNVGRL 129
Query: 446 CVDLPTIVPATALAVVEMLK 505
V P P T V+ ML+
Sbjct: 130 SVGKPVFQPCTPYGVMVMLR 149
Score = 48.4 bits (110), Expect = 2e-04
Identities = 25/62 (40%), Positives = 36/62 (58%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
MA I+DGKA+A +I+ E+ + + G G P + ++VGDD AS YV K +A
Sbjct: 1 MAHIIDGKAIAAKIRSEIASGVRELQGKG-VTPGLAVVLVGDDQASRVYVSMKEKACNDA 59
Query: 237 GI 242
GI
Sbjct: 60 GI 61
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 78.2 bits (184), Expect = 2e-13
Identities = 39/82 (47%), Positives = 57/82 (69%), Gaps = 3/82 (3%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVP-DT-INERRVCDAIAPEKDIDGFHIINIGRL 445
ITE +LL +I +LNED V GI+VQ+P+ DT I+ R+ DA++PEKD+DG H +N GRL
Sbjct: 76 ITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRL 135
Query: 446 CV-DLPTIVPATALAVVEMLKR 508
+ DL +P T +E+++R
Sbjct: 136 AIGDLGGFLPCTPWGCLELIRR 157
Score = 46.0 bits (104), Expect = 9e-04
Identities = 24/64 (37%), Positives = 40/64 (62%), Gaps = 1/64 (1%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKI-AQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
A+I+ G A+A I++EL+ ++ A L + P +R + VG S+ Y+R K++AA +
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 237 GIDA 248
GIDA
Sbjct: 64 GIDA 67
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 78.2 bits (184), Expect = 2e-13
Identities = 34/82 (41%), Positives = 57/82 (69%), Gaps = 2/82 (2%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINER--RVCDAIAPEKDIDGFHIINIGR 442
D ++++L+++I LN+D VDGIL+QLP+P + E+ + AI P+KD+DGF ++N GR
Sbjct: 67 DTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVDGFSLVNRGR 126
Query: 443 LCVDLPTIVPATALAVVEMLKR 508
+ D P + ALA +E+++R
Sbjct: 127 MSGDRPGFISCAALACLEVIER 148
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 77.8 bits (183), Expect = 2e-13
Identities = 39/100 (39%), Positives = 60/100 (60%), Gaps = 5/100 (5%)
Frame = +2
Query: 224 RKIC---GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAI 394
RK C G + ++ +++E L+S++ LN + V GILVQLP+P INE + AI
Sbjct: 61 RKACAEVGIKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPKHINEEHILGAI 120
Query: 395 APEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKR 508
+ +KD+DGFH +NIG+L + P +P T +E+L R
Sbjct: 121 SIDKDVDGFHPLNIGKLAMKGREPLFLPCTPKGCLELLAR 160
Score = 43.2 bits (97), Expect = 0.006
Identities = 22/61 (36%), Positives = 34/61 (55%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A+I+DGKA+A I+ E+ +++ + P + +IVG S TYV K +A VG
Sbjct: 9 AKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTKRKACAEVG 68
Query: 240 I 242
I
Sbjct: 69 I 69
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 77.8 bits (183), Expect = 2e-13
Identities = 35/81 (43%), Positives = 56/81 (69%), Gaps = 1/81 (1%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
SDI E+QL+ +I+ +ED SV GI+VQLP+PD +N+ + +I P+KD+DG N+G++
Sbjct: 155 SDIKEDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDAIIQSIDPKKDVDGLTSTNLGQI 214
Query: 446 CVD-LPTIVPATALAVVEMLK 505
+ P +P T L ++E+LK
Sbjct: 215 MISKKPLYIPCTPLGILEILK 235
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 77.8 bits (183), Expect = 2e-13
Identities = 41/106 (38%), Positives = 62/106 (58%)
Frame = +2
Query: 188 SEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 367
S ++R++ RK+ G + +D +EE LL+ I +LN D V GILVQLP+P I
Sbjct: 46 SHIYVRKKIEQCRKV-GMESVEHRLPADCSEEDLLALIASLNADERVHGILVQLPLPAQI 104
Query: 368 NERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLK 505
+ +V D I P KD+DGFH +N+ RL +VP T + + +L+
Sbjct: 105 DSGKVLDTIDPRKDVDGFHPVNVFRLSTGTGGLVPCTPMGCMILLR 150
Score = 58.0 bits (134), Expect = 2e-07
Identities = 26/65 (40%), Positives = 43/65 (66%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
MA I+ G A A + +L + +A++ + APT+ ++VGDDPASH YVR K+E + V
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARFSQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRKV 60
Query: 237 GIDAL 251
G++++
Sbjct: 61 GMESV 65
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 77.0 bits (181), Expect = 4e-13
Identities = 33/84 (39%), Positives = 58/84 (69%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
I ++ +E++L+S+++ LN + V GI+VQLP+P++I++ +V +AI P+KD DG H +N
Sbjct: 67 IELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDADGLHPLN 126
Query: 434 IGRLCVDLPTIVPATALAVVEMLK 505
+G L IVP T +V++L+
Sbjct: 127 LGYLVTGKQGIVPCTPAGIVKLLE 150
Score = 37.9 bits (84), Expect = 0.23
Identities = 20/65 (30%), Positives = 38/65 (58%)
Frame = +3
Query: 54 IMARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKF 233
++A++LDG A++ I + L + + G P + ++VG++PAS +YV +K K
Sbjct: 1 MVAKVLDGLAVSAGIFERLHRACCELENNGV-CPKLATVLVGNNPASRSYVLSKHRDCKN 59
Query: 234 VGIDA 248
+GI +
Sbjct: 60 IGIQS 64
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 76.6 bits (180), Expect = 5e-13
Identities = 36/83 (43%), Positives = 52/83 (62%), Gaps = 2/83 (2%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 442
D D++EE LL EI LN+D V+G+L+QLP+P NE + +A+A EKD+DGF N+G
Sbjct: 113 DEDMSEEDLLEEIDRLNKDPKVNGLLIQLPLPKHFNETLITNAVATEKDVDGFARYNVGE 172
Query: 443 LCV--DLPTIVPATALAVVEMLK 505
L P P T ++E++K
Sbjct: 173 LTKKGGAPMFKPCTPNGIMELIK 195
Score = 36.7 bits (81), Expect = 0.54
Identities = 20/40 (50%), Positives = 25/40 (62%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
VV+GRS VG P+A ML ++ D TVTICHR+T
Sbjct: 207 VVLGRSDIVGTPVAAMLRNE---------DCTVTICHRHT 237
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 75.4 bits (177), Expect = 1e-12
Identities = 41/99 (41%), Positives = 61/99 (61%)
Frame = +2
Query: 206 QEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVC 385
+EQ+ SR G + + + ITE LL++I LN+D VDGIL+QLP+P ++ R +
Sbjct: 57 KEQACSR--VGIQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPHLDPRPLL 114
Query: 386 DAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEML 502
AI P+KD+DG H N+GRL D P + T V+++L
Sbjct: 115 YAIHPDKDVDGLHPENLGRLVRDEPGLRSCTPAGVMQLL 153
Score = 50.0 bits (114), Expect = 5e-05
Identities = 25/63 (39%), Positives = 37/63 (58%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A LDGK+LA I+++L + + R+P + + VG+DPAS YVR K +A VG
Sbjct: 6 ATCLDGKSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRVG 65
Query: 240 IDA 248
I +
Sbjct: 66 IQS 68
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 75.4 bits (177), Expect = 1e-12
Identities = 33/81 (40%), Positives = 54/81 (66%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
+ I E +L++ I+ LN++ +DGIL+QLP+P IN ++ +I P+KD+DGFH N+G L
Sbjct: 72 NQIEEIELINLIKKLNKNKCIDGILIQLPLPIKINYLKIITSIDPKKDVDGFHPYNLGSL 131
Query: 446 CVDLPTIVPATALAVVEMLKR 508
C + P T+ V+ +LK+
Sbjct: 132 CQNNPQFRSCTSKGVITLLKK 152
Score = 42.3 bits (95), Expect = 0.011
Identities = 21/59 (35%), Positives = 35/59 (59%)
Frame = +3
Query: 63 RILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
+ILDG ++ +I K++K+KI + + P + I++G++PAS YV K EA G
Sbjct: 4 KILDGLKISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQAG 62
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 75.4 bits (177), Expect = 1e-12
Identities = 36/82 (43%), Positives = 53/82 (64%), Gaps = 1/82 (1%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 442
+ D ++E+LL I LN D +V GILVQLP+P I++ V +AI+PEKD+DGFH N G+
Sbjct: 70 EHDTSQEELLRIIDELNRDAAVHGILVQLPLPRHIDKELVINAISPEKDVDGFHNANAGK 129
Query: 443 LCV-DLPTIVPATALAVVEMLK 505
L L ++P T + ++K
Sbjct: 130 LATGQLDCMIPCTPQGCIHLIK 151
Score = 44.4 bits (100), Expect = 0.003
Identities = 23/67 (34%), Positives = 36/67 (53%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M I+DGK +A + L+ + + P + +IVGDDPAS YV NK A+ +
Sbjct: 1 MREIIDGKLVARGLLDRLRVSVDRLKAEHGIVPHLVVVIVGDDPASKLYVGNKQRKAEEL 60
Query: 237 GIDALTL 257
G+ + T+
Sbjct: 61 GLQSRTI 67
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 72.5 bits (170), Expect = 9e-12
Identities = 32/86 (37%), Positives = 54/86 (62%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
+N ++I + L+ +I LN D + GI+VQLP+P +I+E ++ A+ P KD DGFH +N
Sbjct: 68 VNLSTNIYTDDLILKINELNLDKGISGIIVQLPLPSSIDENKILSAVLPSKDSDGFHPLN 127
Query: 434 IGRLCVDL-PTIVPATALAVVEMLKR 508
+G L + +P TAL + ++K+
Sbjct: 128 VGYLHSGINQGFIPCTALGCLAVIKK 153
Score = 57.6 bits (133), Expect = 3e-07
Identities = 29/62 (46%), Positives = 41/62 (66%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 245
I+DGKALA EI +LK +I + +P + ++VGD+PAS YV+NK++ A VGID
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEKTKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGID 64
Query: 246 AL 251
L
Sbjct: 65 TL 66
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 71.7 bits (168), Expect = 2e-11
Identities = 42/117 (35%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Frame = +2
Query: 188 SEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 367
S ++R +Q ++ G R I S +E L+ +I LN D++V GILVQLPVP I
Sbjct: 47 SHLYVRNKQR-KAEMLGLRSETILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPKHI 105
Query: 368 NERRVCDAIAPEKDIDGFHIINIGRLCVDLP--TIVPATALAVVEMLKRLTSTHSVA 532
++ + + I P KD+DGFH N+GRL ++P T + ++K T TH+++
Sbjct: 106 DKNLIINTIDPRKDVDGFHNDNVGRLFTGQKRNCLIPCTPRGCLYLIK--TVTHNLS 160
Score = 49.6 bits (113), Expect = 7e-05
Identities = 26/66 (39%), Positives = 39/66 (59%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A I++GKA+A +I L I + P + ++VGDDPASH YVRNK A+ +G
Sbjct: 3 ANIINGKAIAEDITGTLATCINDLKLQYSLVPCLIVVLVGDDPASHLYVRNKQRKAEMLG 62
Query: 240 IDALTL 257
+ + T+
Sbjct: 63 LRSETI 68
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 71.7 bits (168), Expect = 2e-11
Identities = 31/83 (37%), Positives = 51/83 (61%), Gaps = 1/83 (1%)
Frame = +2
Query: 260 RDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIG 439
+ SD T +L+ I LN D ++ GILVQLP+P ++ + + I P+KD+DG H +N+G
Sbjct: 63 KPSDATLSDILALIHQLNNDENIHGILVQLPLPKHLDAQAILSTITPDKDVDGLHPVNVG 122
Query: 440 RLCV-DLPTIVPATALAVVEMLK 505
+L + + +P T +VE+ K
Sbjct: 123 KLLLGETDGFIPCTPAGIVELCK 145
>UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=2; Catarrhini|Rep: PREDICTED:
similar to Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor -
Macaca mulatta
Length = 111
Score = 69.7 bits (163), Expect = 6e-11
Identities = 29/61 (47%), Positives = 45/61 (73%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++ G+ LA EIK+E++Q++ +WV GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQEIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAADVG 96
Query: 240 I 242
+
Sbjct: 97 M 97
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 69.7 bits (163), Expect = 6e-11
Identities = 29/77 (37%), Positives = 48/77 (62%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD 454
T+++LL+ + LN D + G+LVQ PVP I++ V A++P+KD+DG + N GRL
Sbjct: 76 TQDELLAVVAKLNADPKIHGVLVQFPVPPHISQMDVVAALSPDKDVDGLTVTNAGRLASG 135
Query: 455 LPTIVPATALAVVEMLK 505
LP + P T + +++
Sbjct: 136 LPALAPCTPTGCMMLIR 152
Score = 49.6 bits (113), Expect = 7e-05
Identities = 21/61 (34%), Positives = 37/61 (60%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A+++DGKA A +++ ++ +++A P + ++VG+DPAS YVRNK E G
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAEHGVTPGLAVVLVGEDPASQVYVRNKGEQTTAAG 63
Query: 240 I 242
+
Sbjct: 64 M 64
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 68.5 bits (160), Expect = 1e-10
Identities = 31/94 (32%), Positives = 55/94 (58%), Gaps = 3/94 (3%)
Frame = +2
Query: 236 GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDT--INERRVCDAIAPEKD 409
G + ++ + TE +LL+++ LN D GI+VQ+P+ IN + D ++P+KD
Sbjct: 67 GIKATHVKMPNTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKD 126
Query: 410 IDGFHIINIGRLCV-DLPTIVPATALAVVEMLKR 508
+DG + IN GR+ + D+ +P T +E++KR
Sbjct: 127 VDGLNTINEGRVAIGDMSGFLPCTPNGCIELIKR 160
Score = 39.5 bits (88), Expect = 0.076
Identities = 23/62 (37%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQ-WVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
+L G LA EI++ L + +A L N AP + + VG S+ Y+R K++AA +GI
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 243 DA 248
A
Sbjct: 69 KA 70
Score = 33.9 bits (74), Expect = 3.8
Identities = 21/43 (48%), Positives = 27/43 (62%)
Frame = +3
Query: 528 SQRVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
+Q VV+GRSK VG P+A +L K H +ATVT+CH T
Sbjct: 168 AQAVVLGRSKIVGTPVAELL---KWH------NATVTVCHSRT 201
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 68.5 bits (160), Expect = 1e-10
Identities = 35/79 (44%), Positives = 47/79 (59%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 442
D+ T+ QL I+NLN DNSV GILVQLP+P+ ++E I+P KD+DG N G
Sbjct: 70 DASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDVDGLTPHNAGL 129
Query: 443 LCVDLPTIVPATALAVVEM 499
L + +V T V+EM
Sbjct: 130 LAMKKAALVACTPSGVMEM 148
Score = 48.8 bits (111), Expect = 1e-04
Identities = 23/58 (39%), Positives = 36/58 (62%)
Frame = +3
Query: 69 LDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
+DGK ++ +K +K+ + + G P + ++VGD+PAS TYVRNK A + VGI
Sbjct: 6 IDGKVISQSVKDRVKKAVEELKNQGIN-PCLATVLVGDNPASATYVRNKHRACEEVGI 62
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 68.5 bits (160), Expect = 1e-10
Identities = 34/99 (34%), Positives = 60/99 (60%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
+ + D+T+++L+ I+ L+ D V+GI+V+ P+P TI+ + +I KD+D N
Sbjct: 63 LEKYEDLTKQELVRRIEELSADKDVNGIMVENPLPKTIDYYDIVKSIPYYKDVDALSPYN 122
Query: 434 IGRLCVDLPTIVPATALAVVEMLKRLTSTHSVATXRDRS 550
G + ++ +VPATA+AVV++LK + AT +RS
Sbjct: 123 QGSIAINREFLVPATAMAVVDILKYYGYEKTTATIINRS 161
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 68.5 bits (160), Expect = 1e-10
Identities = 36/107 (33%), Positives = 60/107 (56%)
Frame = +2
Query: 188 SEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 367
S+ ++R + S K+ G I + +DI++ +L + I LN + G +VQLP+P +
Sbjct: 49 SQAYVRGKHSDCAKV-GINSIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHL 107
Query: 368 NERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKR 508
+E + I P KD DG H N+GRL ++ P +P T +V +L+R
Sbjct: 108 DENAALERIDPGKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRR 154
Score = 48.8 bits (111), Expect = 1e-04
Identities = 26/61 (42%), Positives = 36/61 (59%)
Frame = +3
Query: 69 LDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 248
LDGKA EI +LK+++A G R P + ++VGDDP S YVR K VGI++
Sbjct: 9 LDGKATRDEIFVDLKERVAALTEQG-RTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINS 67
Query: 249 L 251
+
Sbjct: 68 I 68
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 68.5 bits (160), Expect = 1e-10
Identities = 32/80 (40%), Positives = 50/80 (62%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
+D +E L+ I LNED ++G++VQLP P+ I+ + + I P KD+DG NIGR+
Sbjct: 70 ADTKQEVALNLIDKLNEDPDINGVMVQLPAPEQIDADELLERIDPNKDVDGLTPSNIGRI 129
Query: 446 CVDLPTIVPATALAVVEMLK 505
++ I PATA ++ +LK
Sbjct: 130 WMENHFIEPATAEGIIALLK 149
Score = 44.4 bits (100), Expect = 0.003
Identities = 26/62 (41%), Positives = 36/62 (58%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M +ILDGK +A + ++LK+K+ G P I +GDDPAS YVR K A+ +
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEEGI-TPHFCVINIGDDPASKIYVRTKKRRAEKM 59
Query: 237 GI 242
GI
Sbjct: 60 GI 61
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 68.5 bits (160), Expect = 1e-10
Identities = 42/112 (37%), Positives = 62/112 (55%), Gaps = 8/112 (7%)
Frame = +2
Query: 236 GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP--DTINERRVCDAIAPEKD 409
G + +I TE +++ I +LNED++V G LVQLP+ ++IN V +AIAPEKD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 410 IDGFHIINIGRLC-VDL-PTIVPATALAVVEMLKR----LTSTHSVATXRDR 547
+DG IN GRL DL +P T +E++K + H+V R +
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSK 175
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 67.3 bits (157), Expect = 3e-10
Identities = 33/90 (36%), Positives = 52/90 (57%)
Frame = +2
Query: 236 GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 415
G C +N ITE L+ I +LN ++ +D ILVQLP+P IN +V + I +KD+D
Sbjct: 63 GVTCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVD 122
Query: 416 GFHIINIGRLCVDLPTIVPATALAVVEMLK 505
GF +G L + ++P+T ++ +LK
Sbjct: 123 GFTPKILGNLMLGHYNLLPSTPKGIIALLK 152
Score = 43.2 bits (97), Expect = 0.006
Identities = 21/65 (32%), Positives = 38/65 (58%)
Frame = +3
Query: 63 RILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
+I+DGK ++ IK ++ ++I + R P + I +G++ AS TY++NK A + VG+
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGV 64
Query: 243 DALTL 257
L
Sbjct: 65 TCKVL 69
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 66.9 bits (156), Expect = 4e-10
Identities = 31/81 (38%), Positives = 52/81 (64%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
+D +EE +L+ I +LN + V GI+++LP+P I++ RV A+ P+KD+DG H IN G +
Sbjct: 70 ADSSEESILALIDSLNANPDVHGIMIELPLPKHISKERVMAAVRPDKDVDGVHPINRGYI 129
Query: 446 CVDLPTIVPATALAVVEMLKR 508
+ PAT + +E++ R
Sbjct: 130 LSGEEGLFPATPESCIEIMLR 150
Score = 56.0 bits (129), Expect = 8e-07
Identities = 24/63 (38%), Positives = 43/63 (68%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
MA++LDGK ++ +K+E+K+++ +W G P + ++VGDDPAS Y ++K + + +
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQGVN-PKLAVVLVGDDPASVVYAKSKQKVSDSL 59
Query: 237 GID 245
GID
Sbjct: 60 GID 62
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 66.9 bits (156), Expect = 4e-10
Identities = 30/83 (36%), Positives = 54/83 (65%)
Frame = +2
Query: 197 HLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINER 376
+ R +Q + K+ G + I D+++ ++L I + N+D ++ IL+QLP+P +N+
Sbjct: 48 YTRNKQKNAEKL-GMKSILRKFPKDVSQAEVLQAIHHYNDDPTIHAILIQLPLPKHLNQT 106
Query: 377 RVCDAIAPEKDIDGFHIINIGRL 445
+ +AIAPEKD+DGF+ N+G+L
Sbjct: 107 ELIEAIAPEKDVDGFNSKNVGKL 129
Score = 44.0 bits (99), Expect = 0.004
Identities = 23/65 (35%), Positives = 40/65 (61%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M I++G+ +A ++ +E K ++ + G P I I+VGDDPAS Y RNK + A+ +
Sbjct: 1 MTNIINGRQIAKQLNQETKTRVDKLKEEGI-IPGIVVILVGDDPASVIYTRNKQKNAEKL 59
Query: 237 GIDAL 251
G+ ++
Sbjct: 60 GMKSI 64
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 66.5 bits (155), Expect = 6e-10
Identities = 35/105 (33%), Positives = 54/105 (51%)
Frame = +2
Query: 188 SEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 367
SE ++ +Q ++ G ++ D + + + L + LN V GILVQ P PD +
Sbjct: 45 SETYVSMKQQDCEEV-GIAAEDVRIDPEASADTLFDTVAELNAREDVHGILVQDPTPDHV 103
Query: 368 NERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEML 502
+ RV A+ P KD+DGFH N+G+L P P T V ++L
Sbjct: 104 PDERVLSAVDPAKDVDGFHPENVGKLVGGTPRFKPCTPHGVQKLL 148
Score = 35.5 bits (78), Expect = 1.2
Identities = 19/64 (29%), Positives = 34/64 (53%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M I+DG A+A +++ +L + + + P + +++ D AS TYV K + + V
Sbjct: 1 MTEIIDGDAVAAQLRADLTGAV-ETLETAGVTPRLATVLMNDKQASETYVSMKQQDCEEV 59
Query: 237 GIDA 248
GI A
Sbjct: 60 GIAA 63
Score = 35.5 bits (78), Expect = 1.2
Identities = 19/40 (47%), Positives = 25/40 (62%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
VV+GRS VG P+A +L + G +ATVTICH +T
Sbjct: 161 VVVGRSNIVGKPLANLLA-----QKAAGGNATVTICHSHT 195
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 66.5 bits (155), Expect = 6e-10
Identities = 34/92 (36%), Positives = 53/92 (57%)
Frame = +2
Query: 227 KICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEK 406
K G C ++ + + EQ+ S + L D V GI++Q P+PD + + +AI P K
Sbjct: 57 KRTGILCDIVDLGAAASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALREAINPAK 116
Query: 407 DIDGFHIINIGRLCVDLPTIVPATALAVVEML 502
D+DG + +++GRL LP PATA AV+ +L
Sbjct: 117 DVDGANPVSLGRLVARLPAFAPATAQAVIALL 148
Score = 33.5 bits (73), Expect = 5.0
Identities = 22/62 (35%), Positives = 29/62 (46%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M R L G LA I+ + A LG R P + + DD ++ YVR+ AAK
Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALNDLGTR-PKLAVVQATDDESTAWYVRSIASAAKRT 59
Query: 237 GI 242
GI
Sbjct: 60 GI 61
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 66.1 bits (154), Expect = 8e-10
Identities = 34/74 (45%), Positives = 46/74 (62%)
Frame = +2
Query: 284 QLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT 463
++LS IQ LN D VDGIL+QLP+P+ ++E + AI PEKD DG H +N+GRL
Sbjct: 77 EVLSTIQQLNADPRVDGILLQLPLPEGLDEGPLLMAIDPEKDADGLHTLNLGRLLKGEQG 136
Query: 464 IVPATALAVVEMLK 505
T V+ ML+
Sbjct: 137 PRSCTPAGVMAMLR 150
Score = 50.4 bits (115), Expect = 4e-05
Identities = 26/62 (41%), Positives = 36/62 (58%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
MA LDGKALA ++ L+ +I + R P + + VGDDPAS YV NK +A +
Sbjct: 1 MALRLDGKALAKAVESRLQAQIESNLPQAGRPPGLAVLRVGDDPASAVYVANKEKACARI 60
Query: 237 GI 242
G+
Sbjct: 61 GV 62
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 65.7 bits (153), Expect = 1e-09
Identities = 32/74 (43%), Positives = 46/74 (62%)
Frame = +2
Query: 287 LLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTI 466
+L I + D +V GI+VQ P+P + R V + I KD+DG + ++GRL + LP+
Sbjct: 74 ILDTIDTVAADPTVHGIIVQTPLPGGLTSREVGEHIPTAKDVDGMNPSSLGRLALGLPSF 133
Query: 467 VPATALAVVEMLKR 508
PATA AVVE+L R
Sbjct: 134 APATAAAVVEILTR 147
>UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein, putative; n=1; Trypanosoma
cruzi|Rep: Methylenetetrahydrofolate dehydrogenase-like
protein, putative - Trypanosoma cruzi
Length = 375
Score = 65.3 bits (152), Expect = 1e-09
Identities = 29/74 (39%), Positives = 46/74 (62%)
Frame = +2
Query: 233 CGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 412
CG R ++ ++EE+L E++ +++DN+ DG+L+QLP+P + R I P KD+
Sbjct: 57 CGIRFHLLSLPETVSEERLHQELRRISDDNAFDGVLLQLPIPSHLRVRPALLCIHPGKDV 116
Query: 413 DGFHIINIGRLCVD 454
DG H IN G L +D
Sbjct: 117 DGLHPINAGSLFLD 130
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 64.9 bits (151), Expect = 2e-09
Identities = 27/63 (42%), Positives = 45/63 (71%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ++ G+ LA +IK+E++Q++ +WV G++ P + I+VG+ ASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGDKRPHLSMILVGESSASHSYVLNKTRAAADVG 96
Query: 240 IDA 248
I++
Sbjct: 97 INS 99
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 64.9 bits (151), Expect = 2e-09
Identities = 30/83 (36%), Positives = 48/83 (57%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 442
D I EE+L+ I+ LN DN + GI++QLP+P+ I+ + V I KDID IN G+
Sbjct: 70 DESIREEELIKLIEGLNVDNKIHGIMLQLPLPNHIDAKLVTSKIDANKDIDSLTDINTGK 129
Query: 443 LCVDLPTIVPATALAVVEMLKRL 511
+ +P T +++ ++K L
Sbjct: 130 FYKGEKSFIPCTPRSIINLIKSL 152
Score = 36.7 bits (81), Expect = 0.54
Identities = 21/63 (33%), Positives = 35/63 (55%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M I++GKA + + K ++ + I + G P I I VGDD S YV N+ + ++ +
Sbjct: 1 MGDIINGKAESQKYKDKIIEFINERKKQGLDIPCIASITVGDDGGSLYYVNNQKKVSESL 60
Query: 237 GID 245
GI+
Sbjct: 61 GIE 63
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 64.1 bits (149), Expect = 3e-09
Identities = 30/79 (37%), Positives = 47/79 (59%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
+D TEE++L+ + LNED+ + GIL +P+P + RV A+AP+KD+D H +N G +
Sbjct: 70 ADATEEEVLALVCELNEDDHIHGILPMMPLPPHLATDRVAAALAPDKDVDALHPLNAGLV 129
Query: 446 CVDLPTIVPATALAVVEML 502
P T AV+ +L
Sbjct: 130 ATGKSRWAPCTPRAVMAIL 148
Score = 39.5 bits (88), Expect = 0.076
Identities = 23/65 (35%), Positives = 36/65 (55%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
MA ILDGKA+A K ++K K+ + N + ++VG+D AS Y V+ A +
Sbjct: 1 MALILDGKAVAAAYKAKIKAKV-DALAAQNITCGLAILLVGNDAASRIYADRLVKLATGL 59
Query: 237 GIDAL 251
G+ A+
Sbjct: 60 GVQAV 64
Score = 33.9 bits (74), Expect = 3.8
Identities = 20/40 (50%), Positives = 24/40 (60%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
VVIGRS VG P+A +L LG +ATVT+CH T
Sbjct: 161 VVIGRSNVVGKPLAHLL---------LGQNATVTVCHSKT 191
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 63.7 bits (148), Expect = 4e-09
Identities = 32/82 (39%), Positives = 50/82 (60%), Gaps = 3/82 (3%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRV---CDAIAPEKDIDGFHIINIG 439
D T+E+LL+ I +LN++ V IL+QLP+P + + +AI+P KD DGFH N+G
Sbjct: 78 DATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKDADGFHPYNMG 137
Query: 440 RLCVDLPTIVPATALAVVEMLK 505
+L + +VP T V+ L+
Sbjct: 138 KLMIGDEDLVPCTPHGVIRALE 159
Score = 52.4 bits (120), Expect = 1e-05
Identities = 26/63 (41%), Positives = 38/63 (60%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
+RI+DGK LA ++++E++ + P + I+VGDDPAS YVR K A + VG
Sbjct: 8 SRIIDGKVLAQQVEEEVRSGVEDLESNRGIVPGLATILVGDDPASKMYVRLKHRACERVG 67
Query: 240 IDA 248
I A
Sbjct: 68 IKA 70
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 63.3 bits (147), Expect = 5e-09
Identities = 29/84 (34%), Positives = 49/84 (58%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
+N + E +LL I +LN + + GI++Q P+P ++N + +AI +KD++G H N
Sbjct: 59 VNLPDAVGERELLKTIGDLNNSSEITGIMLQTPLPASLNASHLVNAIDFDKDVEGIHNYN 118
Query: 434 IGRLCVDLPTIVPATALAVVEMLK 505
+G+L + P T AV+ MLK
Sbjct: 119 LGKLISKEEGVRPCTPKAVISMLK 142
Score = 32.7 bits (71), Expect = 8.8
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 1/46 (2%)
Frame = +3
Query: 522 IRSQRV-VIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
I Q+V +IGRS VG P+A+M+ ++ +ATVT+CH T
Sbjct: 148 IEGQKVTIIGRSMTVGSPLALMMTAE---------NATVTVCHTRT 184
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 62.9 bits (146), Expect = 7e-09
Identities = 33/80 (41%), Positives = 49/80 (61%), Gaps = 1/80 (1%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
DIT+E+ + ++ +N+D +V+GIL P+P +NE + IAPEKD+D F IN ++
Sbjct: 77 DITQEEYIDVLKRVNDDKNVNGILCFRPLPKHLNEEVIKYVIAPEKDVDCFSPINSAKVM 136
Query: 449 V-DLPTIVPATALAVVEMLK 505
D P T AVVE+LK
Sbjct: 137 EGDKSGFPPCTPTAVVEILK 156
>UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-prov
protein, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to Mthfd2-prov protein, partial -
Ornithorhynchus anatinus
Length = 161
Score = 62.5 bits (145), Expect = 9e-09
Identities = 24/56 (42%), Positives = 42/56 (75%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAA 227
A ++ G+ LA +I++E++ ++ +WV GN+ P + I+VG++PASH+YV NK +AA
Sbjct: 47 AVVISGRKLARQIREEVRHEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTKAA 102
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 62.1 bits (144), Expect = 1e-08
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
S+ E++ ++ LNED GI++++P+P + +V D I P KD+D N+GRL
Sbjct: 67 SEKEEDKFFDTLEKLNEDKDTHGIMIEMPLPKGFDVDKVYDTINPYKDVDCISNYNMGRL 126
Query: 446 CVDLPTIVPATALAVVEMLKR----LTSTHSVATXRDRSFQK 559
P VP T A++ +L+ L H+V R K
Sbjct: 127 FAGKPLFVPCTPKAIIHILENTGVDLEGKHAVVIGRSNILGK 168
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/61 (36%), Positives = 39/61 (63%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 245
I+DGK ++ IK+E+K++I ++ P + ++ GDD +S Y +KV+A + VGI+
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF----GYKPRLAILMAGDDESSKVYANSKVKACESVGIE 60
Query: 246 A 248
A
Sbjct: 61 A 61
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 62.1 bits (144), Expect = 1e-08
Identities = 30/80 (37%), Positives = 50/80 (62%), Gaps = 1/80 (1%)
Frame = +2
Query: 269 DITEEQLLSEIQN-LNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
D E++ + ++ N LN DN++DG+L+QLP+ +E+R+ I PEKD+DG + NIG+L
Sbjct: 71 DTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVDGLNEQNIGKL 130
Query: 446 CVDLPTIVPATALAVVEMLK 505
+ + T +V +LK
Sbjct: 131 VKNEQAMRSCTPAGIVNLLK 150
Score = 49.2 bits (112), Expect = 9e-05
Identities = 26/62 (41%), Positives = 37/62 (59%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M+ LDGK L++EI++ L+ I + R P + I +G+DPAS YV NK +A V
Sbjct: 1 MSLKLDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRV 60
Query: 237 GI 242
GI
Sbjct: 61 GI 62
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 61.7 bits (143), Expect = 2e-08
Identities = 34/106 (32%), Positives = 60/106 (56%), Gaps = 3/106 (2%)
Frame = +2
Query: 188 SEPHLRQEQS*SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 367
SE ++R + + ++ G R I+ + T E+L+ I+ LNE+ V GIL+Q PVP I
Sbjct: 86 SETYVRMKGNACARL-GIRSERIHMPKETTTEELVKTIEELNENKEVHGILLQHPVPGHI 144
Query: 368 NERRVCDAIAPEKDIDGFHIINIGRLCVDL---PTIVPATALAVVE 496
+ER+ + I+ +KD+DG G+ + P+ PA +A+++
Sbjct: 145 DERKAFETISIDKDVDGVTSHGYGQTALGFGTYPSCTPAAIMAIID 190
Score = 47.2 bits (107), Expect = 4e-04
Identities = 25/59 (42%), Positives = 35/59 (59%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
ILDGK +A ++K+ L ++ G P + I+VGDDP+S TYVR K A +GI
Sbjct: 45 ILDGKRVAADVKEGLMPRVENLTQKGI-TPCLATILVGDDPSSETYVRMKGNACARLGI 102
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 61.7 bits (143), Expect = 2e-08
Identities = 29/80 (36%), Positives = 44/80 (55%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
++ T+ +L + LN DN VDGILVQ P+P ++ V ++ EKD DG ++G
Sbjct: 71 AETTQSELNQILSKLNNDNGVDGILVQFPLPKHLSSDEVLKLVSAEKDADGLTYESLGYF 130
Query: 446 CVDLPTIVPATALAVVEMLK 505
P + P T V+E+LK
Sbjct: 131 FAGKPLVSPCTPAGVMEILK 150
Score = 58.0 bits (134), Expect = 2e-07
Identities = 27/62 (43%), Positives = 40/62 (64%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M ILDGK +A E++ L ++A++ RAP + +IVGDD ASH YV+NK A + +
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETYGRAPQLSVVIVGDDKASHVYVKNKKIACEKI 60
Query: 237 GI 242
G+
Sbjct: 61 GM 62
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 61.3 bits (142), Expect = 2e-08
Identities = 30/64 (46%), Positives = 43/64 (67%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ILDGKALA +I+++L ++ R P++ I+VGDDPAS TYVR K A + VG
Sbjct: 14 ATILDGKALAKQIEQQLSTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACQRVG 73
Query: 240 IDAL 251
+D++
Sbjct: 74 MDSI 77
Score = 52.4 bits (120), Expect = 1e-05
Identities = 28/90 (31%), Positives = 45/90 (50%)
Frame = +2
Query: 236 GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 415
G I + S T +L+++I LN + V GIL+Q PVP I+ER + I KD+D
Sbjct: 73 GMDSIRVEMPSATTTAELMAKIDELNNNPDVHGILLQHPVPAHIDERACFEQIDLAKDVD 132
Query: 416 GFHIINIGRLCVDLPTIVPATALAVVEMLK 505
G + GR+ + T ++ +L+
Sbjct: 133 GVTCLGFGRMAMQQSAYGSCTPQGIMHLLE 162
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 61.3 bits (142), Expect = 2e-08
Identities = 32/79 (40%), Positives = 51/79 (64%), Gaps = 1/79 (1%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV 451
I E++L S I +LN D++V GI+VQLP+P I+ ++ I KD+DG + INIG L +
Sbjct: 73 IEEKKLFSVIDDLNCDSTVHGIIVQLPLPPHIDALKLFARIDSRKDVDGLNPINIGYLNI 132
Query: 452 DL-PTIVPATALAVVEMLK 505
++P TAL +++L+
Sbjct: 133 GANQGLIPCTALGCIDLLQ 151
Score = 35.5 bits (78), Expect = 1.2
Identities = 23/64 (35%), Positives = 32/64 (50%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M I+DGK LA E K + + I+VG++ AS YV NKV AK +
Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAI 60
Query: 237 GIDA 248
G+D+
Sbjct: 61 GMDS 64
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 61.3 bits (142), Expect = 2e-08
Identities = 34/92 (36%), Positives = 50/92 (54%)
Frame = +2
Query: 233 CGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 412
C + C + R+++ E +L+ + LN D V GILV P+P I+E V A+ P KDI
Sbjct: 62 CRYVCERLPREAE--EADVLAVVGKLNADPRVSGILVLRPLPGHISEPAVFSALDPLKDI 119
Query: 413 DGFHIINIGRLCVDLPTIVPATALAVVEMLKR 508
+ H +N G L + P VP+T A +L R
Sbjct: 120 EAVHPVNAGLLALGRPRYVPSTPAACFYLLDR 151
Score = 36.7 bits (81), Expect = 0.54
Identities = 17/50 (34%), Positives = 30/50 (60%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVR 209
AR++DG+ +A E+KK + ++ G R P + ++VG+D A+ Y R
Sbjct: 3 ARVIDGRPIAGELKKRVASEVEGLAARGVR-PGLATVLVGEDYAARAYER 51
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 60.9 bits (141), Expect = 3e-08
Identities = 31/78 (39%), Positives = 46/78 (58%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV 451
IT +L + I LN D V GI++Q PVP I+ + + A+ P KD++G H +IG +
Sbjct: 77 ITSGELEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPLKDVEGMHPASIGNIVY 136
Query: 452 DLPTIVPATALAVVEMLK 505
+ + P TA A VE+LK
Sbjct: 137 NQLDLAPCTAAASVELLK 154
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 60.5 bits (140), Expect = 4e-08
Identities = 27/83 (32%), Positives = 50/83 (60%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
+++ E+++S ++ L D SV+G+ V P P ++E+ + ++ EKD++G + N+G L
Sbjct: 62 NVSPEEIVSTLKKLGSDESVNGVFVARPFPLGLDEKEILSSVPVEKDVEGVNPANLGLLL 121
Query: 449 VDLPTIVPATALAVVEMLKRLTS 517
D P TA A V +L+R T+
Sbjct: 122 YDEEIFPPCTAEAAVRILERETN 144
Score = 35.5 bits (78), Expect = 1.2
Identities = 21/47 (44%), Positives = 28/47 (59%), Gaps = 1/47 (2%)
Frame = +3
Query: 519 HIRSQRV-VIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
++ +RV V+GRS VG P+A+ML G DATVT+CH T
Sbjct: 144 NLSGKRVTVVGRSVTVGKPLALMLLKK-------GRDATVTVCHSRT 183
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 60.5 bits (140), Expect = 4e-08
Identities = 26/77 (33%), Positives = 43/77 (55%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD 454
T+ LL+ +++ N+ VD ++Q P+P + + + PEKD DG H +N+GRL +
Sbjct: 74 TQSDLLAAVRDFNDSPDVDAYIIQYPLPKGFDFNEALNLMLPEKDADGLHPVNLGRLVLQ 133
Query: 455 LPTIVPATALAVVEMLK 505
P VP T + ML+
Sbjct: 134 EPGPVPCTPAGIRAMLQ 150
Score = 40.3 bits (90), Expect = 0.044
Identities = 22/61 (36%), Positives = 37/61 (60%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A++L+GK +A + +++ +++A G +P + I+VGDD S +YV K E K VG
Sbjct: 3 AQLLEGKVVAAAVLEDVARRVAVLKDKGI-SPGLGTILVGDDGPSVSYVNKKRETCKQVG 61
Query: 240 I 242
I
Sbjct: 62 I 62
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 60.5 bits (140), Expect = 4e-08
Identities = 36/110 (32%), Positives = 57/110 (51%), Gaps = 8/110 (7%)
Frame = +2
Query: 236 GHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 415
G I +D T+ Q+ + I LN D + G +VQLP+P ++ + + I P KD D
Sbjct: 63 GMNSIQRELPADATQAQVEALIDELNADPACHGYIVQLPLPKHLDTDAILERIDPAKDAD 122
Query: 416 GFHIINIGRLCV----DLPTIVPATALAVVEMLKR----LTSTHSVATXR 541
G H N+GRL + ++ + +P T V+E+L+R L+ H V R
Sbjct: 123 GLHPTNLGRLVLNVSGEITSPLPCTPRGVIELLERNGYSLSGKHVVVVGR 172
Score = 48.8 bits (111), Expect = 1e-04
Identities = 26/64 (40%), Positives = 40/64 (62%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A+ILDGKA A IK EL +++A+ G P I ++VG DPAS YV K + + +G
Sbjct: 5 AKILDGKAAAAAIKSELAERVAKLKARG-VTPGIATVLVGADPASQLYVSMKHKQSVEIG 63
Query: 240 IDAL 251
++++
Sbjct: 64 MNSI 67
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 60.1 bits (139), Expect = 5e-08
Identities = 28/60 (46%), Positives = 39/60 (65%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 445
++ T +L I LN+D VDGILVQLP+PD ++ + I P+KD DG H +N+GRL
Sbjct: 75 AETTFRELEKVIAALNDDERVDGILVQLPLPDHLDAVALLHQIDPDKDADGLHPVNLGRL 134
Score = 56.0 bits (129), Expect = 8e-07
Identities = 29/61 (47%), Positives = 40/61 (65%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A++LDGKA+A +I++EL I Q R P + ++VGD+PAS YVRNK +A VG
Sbjct: 6 AKLLDGKAIAAKIQQELSVAITQLQPEIGRPPGLAVLMVGDNPASAAYVRNKEKACAKVG 65
Query: 240 I 242
I
Sbjct: 66 I 66
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/84 (38%), Positives = 52/84 (61%), Gaps = 2/84 (2%)
Frame = +2
Query: 257 NRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINI 436
N ++ +EQL+ IQ +N D GILVQLP+P +N+ + +I EKD+D H+ N+
Sbjct: 176 NFSENVGQEQLIKHIQQMNHD----GILVQLPLPSHLNKLDIIHSIPYEKDVDCLHMHNL 231
Query: 437 GRLCV--DLPTIVPATALAVVEML 502
R+ V +L ++P T AV+++L
Sbjct: 232 QRILVYGELCEMLPCTPAAVLQIL 255
Score = 34.7 bits (76), Expect = 2.2
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 2/73 (2%)
Frame = +3
Query: 36 KNNNFIIMARILDGKALAMEIK-KELKQKIAQWVGLGNRA-PTIRCIIVGDDPASHTYVR 209
K F+ +A IL K L M +L I + + + + P + +VGD PAS +YV
Sbjct: 101 KKETFLFLA-ILAVKKLKMIFNGNQLANTILKTLRITSEIKPKLGICLVGDSPASKSYVN 159
Query: 210 NKVEAAKFVGIDA 248
K++A + + +DA
Sbjct: 160 RKLKACQEINVDA 172
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 58.4 bits (135), Expect = 2e-07
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 1/81 (1%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
+I+E LL+ I LN+D VDGI++ LP+P IN +V ++I KD+DGF N+G L
Sbjct: 70 EISEAYLLNLIDKLNKDTEVDGIMINLPLPPQINATKVLNSIKLIKDVDGFKAENLGLLF 129
Query: 449 VDLPTIV-PATALAVVEMLKR 508
+ P+T ++ ++++
Sbjct: 130 QNNEGFTSPSTPAGIMALIEK 150
Score = 49.6 bits (113), Expect = 7e-05
Identities = 23/59 (38%), Positives = 39/59 (66%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
++DGK LA +IK ++K +I + N P + I+VGDDPAS Y+ ++V++ + +GI
Sbjct: 2 LMDGKELARDIKVKIKAEIDNIKKIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGI 60
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 57.2 bits (132), Expect = 4e-07
Identities = 28/80 (35%), Positives = 43/80 (53%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
+ T+ L I L+ D ++ GIL+ LP+P ++ R I P KD+DG H N G L
Sbjct: 73 ETTQAMLEETISALSFDRTIHGILLHLPLPPGLDSARAIAQIDPAKDVDGVHPYNAGLLA 132
Query: 449 VDLPTIVPATALAVVEMLKR 508
+ P ++P T +E+L R
Sbjct: 133 MGRPGLIPNTPAGGMELLLR 152
Score = 40.7 bits (91), Expect = 0.033
Identities = 20/61 (32%), Positives = 34/61 (55%)
Frame = +3
Query: 60 ARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 239
A ILDG+ALA +++EL+ ++ AP++ + + DPAS Y R + + +G
Sbjct: 3 AIILDGRALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEEIG 62
Query: 240 I 242
I
Sbjct: 63 I 63
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 57.2 bits (132), Expect = 4e-07
Identities = 29/80 (36%), Positives = 46/80 (57%), Gaps = 2/80 (2%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV- 451
T++ L+ +I LN D+S+DG ++QLP+P + +C+ I KDIDG I R
Sbjct: 70 TQDDLIKQIHILNNDDSIDGYIIQLPLPKGFDSNVICEHIDVNKDIDGLSSFAISRNLAN 129
Query: 452 -DLPTIVPATALAVVEMLKR 508
+L P TA ++E+LK+
Sbjct: 130 SNLFHPKPCTANGIIEILKQ 149
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 56.8 bits (131), Expect = 5e-07
Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPV--PDTINERRVCDAIAPEKDIDGFHIINIGRL 445
IT+ L EI LN DN +DGI++QLP+ I+ V D I P KD+DG IN GRL
Sbjct: 75 ITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLKDVDGLTRINAGRL 134
Query: 446 C-VDLP-TIVPATALAVVEMLKRLTSTHSVATXRD 544
+L TI P T + ++++ T + + ++
Sbjct: 135 ARGELQRTIFPCTPFGCLYLVQQATGDANFVSGKE 169
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 56.4 bits (130), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 4/90 (4%)
Frame = +2
Query: 251 NINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDT--INERRVCDAIAPEKDIDGFH 424
++ S T+E++L I ++NED SV G++VQLP+ I+ + + ++ +KD+DG
Sbjct: 115 HVRLPSSATQEEVLLNILSINEDQSVHGLIVQLPLDSVHHIDSECITNTVSADKDVDGLS 174
Query: 425 IINIGRLC-VDLPT-IVPATALAVVEMLKR 508
IN GRL DL +P T +E++++
Sbjct: 175 CINAGRLSRGDLDACFLPCTPSGCLELIRQ 204
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 56.0 bits (129), Expect = 8e-07
Identities = 30/83 (36%), Positives = 50/83 (60%), Gaps = 3/83 (3%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF---HIIN 433
D DI++ LL ++ LNE++ DGI+VQLP+P+ I+ + + + I EKD+DG N
Sbjct: 69 DEDISQNSLLKKLDVLNEES--DGIIVQLPLPEHISPKVIMNGIRLEKDVDGLCEKSTFN 126
Query: 434 IGRLCVDLPTIVPATALAVVEML 502
D + PATA A+++++
Sbjct: 127 FYNDKYDELSFTPATAAAIIDLI 149
Score = 51.2 bits (117), Expect = 2e-05
Identities = 25/61 (40%), Positives = 39/61 (63%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 245
IL+GK +A E ELK++ + L R P + I VGD+PAS Y++NK++ A+ +G+
Sbjct: 3 ILNGKIIAEERTVELKKEFEEITKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVK 62
Query: 246 A 248
A
Sbjct: 63 A 63
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 56.0 bits (129), Expect = 8e-07
Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 442
D+ + +L + LN D+S+ GILVQ P+ D I+E ++ +AI P KD DG N G
Sbjct: 66 DNSWKTDDILRLLSKLNMDSSICGILVQSPLGDGIDESKIFNAIDPLKDADGLSAFNQGL 125
Query: 443 LCVDLPT--IVPATALAVVEMLK 505
L + IVPAT V+ +L+
Sbjct: 126 LFENAKENYIVPATPAGVISLLE 148
Score = 32.7 bits (71), Expect = 8.8
Identities = 20/62 (32%), Positives = 35/62 (56%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
M +ILDG++++ +I +E+K K+A+ G + T I ++ S YV K+ A F
Sbjct: 1 MVQILDGRSVSKKILQEVKDKVAK-AGFPVKLAT---IYNEENEGSKMYVGMKIRRATFA 56
Query: 237 GI 242
G+
Sbjct: 57 GL 58
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 56.0 bits (129), Expect = 8e-07
Identities = 27/85 (31%), Positives = 51/85 (60%), Gaps = 1/85 (1%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 433
I ++ + +L I N++ S DGI+VQLP+ ++ + ++I KD+DG +N
Sbjct: 72 IKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDVDGLSFVN 131
Query: 434 IGRLCV-DLPTIVPATALAVVEMLK 505
+G++ + D +P TALAV+++L+
Sbjct: 132 LGKMILGDKKGFIPCTALAVLKILR 156
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 55.6 bits (128), Expect = 1e-06
Identities = 28/79 (35%), Positives = 48/79 (60%), Gaps = 2/79 (2%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV 451
I++++++ I++LN+ S+DGILVQLP+P ++ + + I KDID H+ N L
Sbjct: 77 ISQKEIVHRIKSLNQKGSIDGILVQLPLPPHLSRLEISNEIKLNKDIDCLHMANFQNLLQ 136
Query: 452 --DLPTIVPATALAVVEML 502
+ I+P T AV+ +L
Sbjct: 137 NGEDNDIIPCTPAAVLHIL 155
>UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasmatales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Picrophilus torridus
Length = 276
Score = 55.6 bits (128), Expect = 1e-06
Identities = 29/85 (34%), Positives = 50/85 (58%)
Frame = +2
Query: 248 ININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 427
++++R I+ E L+ ++ ++ + + GI+++ PVP IN V + I KD+DG
Sbjct: 61 VDLDRYDSISREDLIKLLKRYSQSDDIHGIMIETPVPG-INYYDVVNEIPFYKDVDGMTS 119
Query: 428 INIGRLCVDLPTIVPATALAVVEML 502
N+G L + I PATA AVV++L
Sbjct: 120 YNLGNLYLKNEFIAPATARAVVDIL 144
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 54.0 bits (124), Expect = 3e-06
Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
DI E +LS I NLN + +D I+ QLP+P I++ V + I+ EKD DG +N L
Sbjct: 88 DIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSHIDKNNVINMISSEKDADGLK-LNSNNL- 145
Query: 449 VDLPTIVPATALAVVEMLKR----LTSTHSVATXRDR 547
I+P T A +++L+ L H V R R
Sbjct: 146 DPKANILPCTPAACLKILEEHQICLKDKHVVLIGRGR 182
Score = 36.7 bits (81), Expect = 0.54
Identities = 19/62 (30%), Positives = 38/62 (61%), Gaps = 3/62 (4%)
Frame = +3
Query: 66 ILDGKALAMEIKKELKQKIAQWVGLGN---RAPTIRCIIVGDDPASHTYVRNKVEAAKFV 236
+ +G A +I L+++I +W + R P + I+VG++PAS +Y++ K++A + +
Sbjct: 18 VFNGNKSAKKILSSLRKEI-EWFQKQSDLSRKPGLGIILVGNNPASLSYIKKKLQACEAI 76
Query: 237 GI 242
GI
Sbjct: 77 GI 78
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 53.6 bits (123), Expect = 4e-06
Identities = 30/80 (37%), Positives = 48/80 (60%), Gaps = 2/80 (2%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD 454
TEE+++ E+ LN+D+ V GI + LP T + V +AI P+KD+DG +N+GR+ +
Sbjct: 60 TEEEVIEEVLRLNKDSRVHGIFLHLP--QTFLSKSVRNAIKPQKDVDGVCDLNVGRVVLG 117
Query: 455 LPT--IVPATALAVVEMLKR 508
T A AV+E+L +
Sbjct: 118 DKTDGFTSPVAGAVLELLAK 137
>UniRef50_A4M873 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Petrotoga mobilis
SJ95|Rep: Tetrahydrofolate dehydrogenase/cyclohydrolase
- Petrotoga mobilis SJ95
Length = 273
Score = 53.6 bits (123), Expect = 4e-06
Identities = 25/81 (30%), Positives = 43/81 (53%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV 451
+ L ++++ NED+ D I + P+ E + I PEKD++G + NIG +
Sbjct: 61 VESNDLTNDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFY 120
Query: 452 DLPTIVPATALAVVEMLKRLT 514
+ VP TA AVV++++ T
Sbjct: 121 EKELFVPCTAEAVVKIIEDTT 141
Score = 34.3 bits (75), Expect = 2.9
Identities = 20/40 (50%), Positives = 25/40 (62%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
V++GRS VG P A+ML +RH G DATVT+ H T
Sbjct: 149 VILGRSTTVGKPAAIML---QRH----GRDATVTVTHTKT 181
>UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Macaca mulatta|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Macaca mulatta
Length = 198
Score = 53.2 bits (122), Expect = 6e-06
Identities = 23/59 (38%), Positives = 40/59 (67%)
Frame = +2
Query: 332 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKR 508
G LVQLP+ +ER++C+A +P+K +D F ++N+G C+D +++ AT V E +K+
Sbjct: 31 GHLVQLPLAGHTDERKICNAFSPDKGVDDFPVMNVGLKCLDQYSMLLATRWDVRETIKQ 89
Score = 41.5 bits (93), Expect = 0.019
Identities = 25/47 (53%), Positives = 26/47 (55%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKRQTWK 677
VV GRSK V MPI M LH D HE DATV I Y+P Q K
Sbjct: 100 VVAGRSKIVRMPIVMSLHIDGAHERPRD-DATVIISPGYSPNEQLKK 145
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 52.4 bits (120), Expect = 1e-05
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 4/85 (4%)
Frame = +2
Query: 263 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF----HII 430
D +IT+++LL + +NE+ DGIL+QLP+P + + + DA+ EKDIDG I
Sbjct: 67 DENITQKRLLLAMDEINEN--WDGILIQLPLPKHLPKEVILDAVPYEKDIDGLSHRNEFI 124
Query: 431 NIGRLCVDLPTIVPATALAVVEMLK 505
D VPA A AV+E+++
Sbjct: 125 LYNEKNSDDKFFVPAAARAVLELIE 149
Score = 37.1 bits (82), Expect = 0.41
Identities = 23/62 (37%), Positives = 38/62 (61%)
Frame = +3
Query: 63 RILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
+IL G+ A + K+LK+++ + + L NR + I VGD S+ YV K++ AK +GI
Sbjct: 2 KILSGREKAEQDLKQLKKELDE-LNL-NRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGI 59
Query: 243 DA 248
+A
Sbjct: 60 EA 61
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 51.6 bits (118), Expect = 2e-05
Identities = 24/78 (30%), Positives = 45/78 (57%), Gaps = 3/78 (3%)
Frame = +2
Query: 281 EQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLP 460
++ L I++LN + V G+++Q P+P ++E+ + A++PEKD+D N RL D
Sbjct: 82 KEALRLIESLNRRDDVTGVIIQKPLPPFVDEKALFSALSPEKDVDALTPENKKRLLTDFD 141
Query: 461 ---TIVPATALAVVEMLK 505
++P T ++E+ K
Sbjct: 142 LDRDVLPCTPAGILELFK 159
>UniRef50_A6LP88 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Thermosipho
melanesiensis BI429|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase - Thermosipho melanesiensis
BI429
Length = 271
Score = 51.2 bits (117), Expect = 2e-05
Identities = 26/73 (35%), Positives = 41/73 (56%)
Frame = +2
Query: 287 LLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTI 466
+L + L+ DN+V+GI V P+ +NE + + + P KDI+G H N+G L
Sbjct: 69 VLKILAELSRDNNVNGIFVTHPLSQ-VNEMEIFENLVPSKDIEGRHPYNLGMLAYGEEFF 127
Query: 467 VPATALAVVEMLK 505
P TA AVV +++
Sbjct: 128 APCTAEAVVRIME 140
Score = 33.1 bits (72), Expect = 6.6
Identities = 18/40 (45%), Positives = 23/40 (57%)
Frame = +3
Query: 537 VVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 656
V++GRS VG P+A+ML R ATVT+CH T
Sbjct: 151 VIVGRSNTVGKPLAIMLLRRDR-------SATVTVCHTKT 183
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 48.0 bits (109), Expect = 2e-04
Identities = 22/57 (38%), Positives = 35/57 (61%)
Frame = +2
Query: 251 NINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 421
++N S+ TE++ + + + DGI++QLP+PD N R+ I PEKD+DGF
Sbjct: 63 HVNIYSNTTEQKEVECVITDIAKSDADGIIIQLPIPDKYNLERLQHLIPPEKDVDGF 119
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 48.0 bits (109), Expect = 2e-04
Identities = 22/55 (40%), Positives = 37/55 (67%)
Frame = +2
Query: 254 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 418
I + IT+ +L+ +I +LN D +V GI++QLPV +++ + +AI P KD+DG
Sbjct: 58 IKLSNQITQAELIEKIISLNHDVNVTGIILQLPVYPHLDKNSLLEAINPLKDVDG 112
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 46.8 bits (106), Expect = 5e-04
Identities = 26/83 (31%), Positives = 45/83 (54%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV 451
I+E+ L+S I+ E G++VQLP+P ++ ++ +++ KDIDG N L
Sbjct: 68 ISEKDLISIIEE--ESKISHGLIVQLPLPLQFDQSKILNSVPITKDIDGLSEKNSKNLYS 125
Query: 452 DLPTIVPATALAVVEMLKRLTST 520
I PATA +++++K T
Sbjct: 126 GKSCIQPATARGIIDLIKEYNFT 148
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 46.4 bits (105), Expect = 7e-04
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 448
+ +E ++++E+ L+ED V G+ + LP + RV A+ PEKD+DG +N G L
Sbjct: 59 ECSEIEIVTEVLKLSEDPGVHGLYLHLPQASLTS--RVLTALKPEKDVDGLSDLNTGCLI 116
Query: 449 -VDLPT-IVPATALAVVEMLKR 508
DL VP AV+E L +
Sbjct: 117 RGDLSAGFVPPVTSAVLEWLSK 138
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 46.0 bits (104), Expect = 9e-04
Identities = 22/69 (31%), Positives = 36/69 (52%)
Frame = +2
Query: 233 CGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 412
CG ++ + + + +L + +N+D VD +L+QLP+P R I P KD+
Sbjct: 86 CGIEVRLVHLSATVQQIELHRTLAAVNDDVEVDAVLLQLPLPPHQRTRSALVHIHPGKDV 145
Query: 413 DGFHIINIG 439
DG H +N G
Sbjct: 146 DGLHPLNAG 154
Score = 35.1 bits (77), Expect = 1.6
Identities = 18/50 (36%), Positives = 28/50 (56%)
Frame = +3
Query: 96 IKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 245
I K+L+Q+I + R P + ++VGD S YV +K+ AA GI+
Sbjct: 40 ISKQLRQRIRASTSVLRRPPCLVVVLVGDGADSIHYVNHKMRAAADCGIE 89
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/48 (39%), Positives = 32/48 (66%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 418
T+++++ +++LN+ VD IL QLP P I++ V + I P KD+DG
Sbjct: 97 TQKEVIQIVEDLNKREDVDSILTQLPFPAQISKTIVINQIEPSKDVDG 144
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 44.0 bits (99), Expect = 0.004
Identities = 25/79 (31%), Positives = 45/79 (56%), Gaps = 1/79 (1%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN-IGRL 445
D+++++LL+ I+++N D +V G L+ P+P ++E V A+ P KD+D + + L
Sbjct: 71 DVSQDELLAAIKDINADPAVHGCLMFRPLPAGLDEDAVAAALDPAKDVDSMTPASLLTTL 130
Query: 446 CVDLPTIVPATALAVVEML 502
P TA AV+ +L
Sbjct: 131 SGRGEGFAPCTAEAVLALL 149
>UniRef50_UPI000023D48A Cluster: hypothetical protein FG10624.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10624.1 - Gibberella zeae PH-1
Length = 302
Score = 41.9 bits (94), Expect = 0.014
Identities = 17/51 (33%), Positives = 34/51 (66%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 421
D + Q++++++ LN++ + GIL+Q P+P +NE V +I P K+I+ +
Sbjct: 84 DASTTQVMTQVKKLNKNPRIHGILIQRPLPRQLNEPEVMRSINPIKNIEEY 134
>UniRef50_Q02046 Cluster: Methylenetetrahydrofolate dehydrogenase
[NAD+]; n=27; Ascomycota|Rep: Methylenetetrahydrofolate
dehydrogenase [NAD+] - Saccharomyces cerevisiae (Baker's
yeast)
Length = 320
Score = 41.5 bits (93), Expect = 0.019
Identities = 30/113 (26%), Positives = 58/113 (51%), Gaps = 9/113 (7%)
Frame = +2
Query: 248 ININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 427
+ + D D EE ++ N D+SV+GI+V PV ++ + + EKD++G +
Sbjct: 70 LRVIEDKDFLEEAIIQA----NGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVEGLNH 125
Query: 428 I-------NIGRLCVD--LPTIVPATALAVVEMLKRLTSTHSVATXRDRSFQK 559
+ N+ L + L +I+P T LA+V++L+ L +++ +R + K
Sbjct: 126 VYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGK 178
>UniRef50_A6RXY2 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 439
Score = 38.7 bits (86), Expect = 0.13
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 1/65 (1%)
Frame = -3
Query: 522 CVDVNLFSISTTANAVAGTMVGRSTHSLPMLIMWKPSISFSGAIASQTLLSL-IVSGTGN 346
CVD ++ ++ A++V G V + LP+ IMW IS ++ +LSL +++G
Sbjct: 112 CVDSSIVPAASVAHSVIGFTVDWTLGLLPICIMWDSKISMKAKVSISGVLSLGLLAGIAT 171
Query: 345 WTRIP 331
RIP
Sbjct: 172 IIRIP 176
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 37.9 bits (84), Expect = 0.23
Identities = 17/38 (44%), Positives = 24/38 (63%), Gaps = 2/38 (5%)
Frame = +2
Query: 401 EKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKR 508
EKD+DGFH +NIG+L + P +P T +E+L R
Sbjct: 1 EKDVDGFHPLNIGKLAMKGRQPLFLPCTPKGCIELLHR 38
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 36.3 bits (80), Expect = 0.71
Identities = 22/84 (26%), Positives = 43/84 (51%), Gaps = 9/84 (10%)
Frame = +2
Query: 281 EQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD-- 454
E + + ++ N D++V GI V P+ + + D I+P KD++G I +L +
Sbjct: 67 ESVRATLEAANRDSAVHGIFVYYPIWGDKRDAELRDLISPHKDVEGLSPHWIKKLYANER 126
Query: 455 -------LPTIVPATALAVVEMLK 505
+I+P T LA++++L+
Sbjct: 127 FDDTERRFKSILPCTPLAIIKLLE 150
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 35.9 bits (79), Expect = 0.94
Identities = 18/75 (24%), Positives = 40/75 (53%)
Frame = +2
Query: 221 SRKICGHRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAP 400
+RK C ++ + ++ + + + I+ +N +NSV GI+V P+ + + +AP
Sbjct: 53 TRKTCQEIGVHFHL-MKLSPKNVATYIRAINANNSVHGIIVYYPIFGDRRDDEIRQLVAP 111
Query: 401 EKDIDGFHIINIGRL 445
KD++G + + R+
Sbjct: 112 SKDVEGLNHQTLHRI 126
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 34.7 bits (76), Expect = 2.2
Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Frame = +2
Query: 317 DNSVDGILVQLPVPD-TINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVV 493
D DGI++QLPV +NE + I KD+DG + N + I+PATA A+
Sbjct: 82 DKEYDGIILQLPVLHFDVNELLLM--IDKNKDLDGLNPENEKAFYENRECIIPATARAIW 139
Query: 494 EMLK 505
LK
Sbjct: 140 TFLK 143
Score = 33.1 bits (72), Expect = 6.6
Identities = 16/65 (24%), Positives = 40/65 (61%)
Frame = +3
Query: 54 IMARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKF 233
+M ++L + + ++ + ELK+K ++ ++ +++GD+ +S YV+ K+E A+
Sbjct: 1 MMKKLLSNELVQIK-RAELKEKFSKL----DQKVKFAIVLIGDNASSKIYVKKKIEFAQD 55
Query: 234 VGIDA 248
+G++A
Sbjct: 56 IGVEA 60
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 34.7 bits (76), Expect = 2.2
Identities = 17/57 (29%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Frame = +3
Query: 75 GKALAMEIKKELKQKIAQWVGLGNR-APTIRCIIVGDDPASHTYVRNKVEAAKFVGI 242
GK LA + + ++ + W L P + ++ DD AS YV++K + AK +G+
Sbjct: 17 GKPLADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAKRAKKLGV 73
Score = 34.3 bits (75), Expect = 2.9
Identities = 21/79 (26%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
Frame = +2
Query: 275 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV- 451
T+E L ++ L+ D +V GI+++LP+ ++ IA KDI+G N+ +
Sbjct: 85 TQEALEQTLRELSADPAVHGIVLELPLAAGLDADAALLHIAARKDIEGLSPANLALIAAG 144
Query: 452 -DLPTIVPATALAVVEMLK 505
+ ++P T +V +L+
Sbjct: 145 REPEALLPPTPRSVRFLLR 163
>UniRef50_UPI000051DDF1 Cluster: ACETYLCHOLINE-BINDING PROTEIN; n=1;
Bulinus truncatus|Rep: ACETYLCHOLINE-BINDING PROTEIN -
Bulinus truncatus
Length = 203
Score = 34.3 bits (75), Expect = 2.9
Identities = 19/42 (45%), Positives = 26/42 (61%), Gaps = 3/42 (7%)
Frame = -3
Query: 444 SLPMLIMWKPSISFSGAIASQTLLS---LIVSGTGNWTRIPS 328
SLP+ MW P +SF AIA+ LLS ++VS G+ +PS
Sbjct: 74 SLPVSKMWTPDLSFYNAIAAPELLSADRVVVSKDGSVIYVPS 115
>UniRef50_A6QZK7 Cluster: Putative uncharacterized protein; n=1;
Ajellomyces capsulatus NAm1|Rep: Putative
uncharacterized protein - Ajellomyces capsulatus NAm1
Length = 297
Score = 34.3 bits (75), Expect = 2.9
Identities = 26/104 (25%), Positives = 53/104 (50%), Gaps = 10/104 (9%)
Frame = +2
Query: 272 ITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF---HIINIGR 442
++ + + I N D VDGI+V P+ + ++ + + KD++G +I N+ +
Sbjct: 76 VSRDDIEDAILVANSDPDVDGIIVYYPIFNNRQDQYLQQIVDISKDVEGLSHRYIFNMYQ 135
Query: 443 --LCVDLP-----TIVPATALAVVEMLKRLTSTHSVATXRDRSF 553
+D P +I+P T LAV+++L+ L +++ +R F
Sbjct: 136 NIRFLDPPENKQKSILPCTPLAVIKILEYLQIYNTILPYGNRLF 179
>UniRef50_Q8ZSG1 Cluster: Alr7549 protein; n=3; Nostocaceae|Rep:
Alr7549 protein - Anabaena sp. (strain PCC 7120)
Length = 246
Score = 33.9 bits (74), Expect = 3.8
Identities = 17/50 (34%), Positives = 28/50 (56%)
Frame = +2
Query: 266 SDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 415
++I EQ + IQ++NE++ V +VQ P+P + P+KDID
Sbjct: 78 ANIAVEQFDNIIQSINENSKVTAAIVQYPIPAKFTSS--IQLLEPQKDID 125
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 33.9 bits (74), Expect = 3.8
Identities = 25/77 (32%), Positives = 42/77 (54%), Gaps = 10/77 (12%)
Frame = +2
Query: 311 NEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG------FHII-NIGRLCVDLPT-- 463
N D+ V GILV PV + + + D ++P KDI+G F++ NI + + T
Sbjct: 88 NNDSCVHGILVYYPVFGGMMDSYLQDVVSPTKDIEGLSTQNRFNLYHNIRFMDGETATKK 147
Query: 464 -IVPATALAVVEMLKRL 511
++P T LA+V+++ L
Sbjct: 148 CVIPCTPLAMVKIIDNL 164
>UniRef50_A0VHR0 Cluster: Polar amino acid ABC transporter, inner
membrane subunit; n=1; Delftia acidovorans SPH-1|Rep:
Polar amino acid ABC transporter, inner membrane subunit
- Delftia acidovorans SPH-1
Length = 399
Score = 33.5 bits (73), Expect = 5.0
Identities = 16/26 (61%), Positives = 19/26 (73%)
Frame = -1
Query: 527 PNVSMLIFSAFPLQPML*PAQW*VDP 450
P +++L F AF L PML PAQW VDP
Sbjct: 242 PLITLLFFGAFVL-PMLVPAQWRVDP 266
>UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate
dehydrogenase; n=1; Hyaloperonospora parasitica|Rep:
Putative methylene tetrahydrofolate dehydrogenase -
Hyaloperonospora parasitica
Length = 328
Score = 33.5 bits (73), Expect = 5.0
Identities = 27/97 (27%), Positives = 48/97 (49%), Gaps = 16/97 (16%)
Frame = +2
Query: 269 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI-------NERRVCDAIAPEKDIDGFHI 427
++ ++ LL+ +Q NED V GILV P T + + D+I+ +KD++G
Sbjct: 80 EVPKDDLLAALQQANEDPDVHGILVYYPCFGTFPSFFGGTMDDFLRDSISIKKDVEGLGQ 139
Query: 428 INIGRLCVDL---------PTIVPATALAVVEMLKRL 511
G L ++ ++P T LA+V++L+ L
Sbjct: 140 FYRGNLYRNIRYVDDEKTQKCVLPCTPLAIVKILEHL 176
>UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase
(NAD+), putative; n=1; Filobasidiella neoformans|Rep:
Methylenetetrahydrofolate dehydrogenase (NAD+), putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 367
Score = 33.5 bits (73), Expect = 5.0
Identities = 13/42 (30%), Positives = 25/42 (59%)
Frame = +2
Query: 299 IQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 424
I NED VDG++V P+ ++ + ++P+KD++G +
Sbjct: 90 ILEANEDPEVDGMMVYYPIYGGRQDQYLQSVVSPQKDVEGLN 131
>UniRef50_O74539 Cluster: Peroxide stress-activated histidine kinase
mak3; n=1; Schizosaccharomyces pombe|Rep: Peroxide
stress-activated histidine kinase mak3 -
Schizosaccharomyces pombe (Fission yeast)
Length = 2344
Score = 33.5 bits (73), Expect = 5.0
Identities = 14/47 (29%), Positives = 28/47 (59%)
Frame = +2
Query: 278 EEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 418
EEQ+ ++ + +D+S++ +L+ L + D + R C IA E ++ G
Sbjct: 1438 EEQIDDDVSPVAQDSSLEELLISLDIIDLTSVMRSCQTIASEIELTG 1484
>UniRef50_Q18E84 Cluster: ATP-dependent DNA helicase; n=1;
Haloquadratum walsbyi DSM 16790|Rep: ATP-dependent DNA
helicase - Haloquadratum walsbyi (strain DSM 16790)
Length = 2216
Score = 33.1 bits (72), Expect = 6.6
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 3/79 (3%)
Frame = +2
Query: 242 RCININRDSDITEEQLLSEIQN-LNED-NSVDGILVQLPVPDTINERRVCDAIA-PEKDI 412
+ I I R +++ Q ++ + LN D NSV+ ++ PV + + RVCDAI+ +DI
Sbjct: 712 KSITILRTEIVSQYQNIAAAADALNIDVNSVEALITGQPVVSDVID-RVCDAISVSSEDI 770
Query: 413 DGFHIINIGRLCVDLPTIV 469
H+I ++LP ++
Sbjct: 771 TIHHVIGPTGTAIELPEVL 789
>UniRef50_P76339 Cluster: Putative sensor-like histidine kinase
yedV; n=22; Enterobacteriaceae|Rep: Putative sensor-like
histidine kinase yedV - Escherichia coli (strain K12)
Length = 452
Score = 33.1 bits (72), Expect = 6.6
Identities = 24/90 (26%), Positives = 45/90 (50%)
Frame = +2
Query: 239 HRCININRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 418
+R +++++D I +++I +N N DG+L +P +TI+ + +I + +ID
Sbjct: 70 NRMMDVSQDILIIHGDSINKI--VNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDA 127
Query: 419 FHIINIGRLCVDLPTIVPATALAVVEMLKR 508
INI + L V A A ML++
Sbjct: 128 LR-INIDEVSPSLTVTVAKLASARHNMLEQ 156
>UniRef50_Q8YFR7 Cluster: Diguanylate cyclase/phosphodiesterase
domain 2; n=30; Alphaproteobacteria|Rep: Diguanylate
cyclase/phosphodiesterase domain 2 - Brucella melitensis
Length = 964
Score = 32.7 bits (71), Expect = 8.8
Identities = 18/66 (27%), Positives = 33/66 (50%)
Frame = -3
Query: 516 DVNLFSISTTANAVAGTMVGRSTHSLPMLIMWKPSISFSGAIASQTLLSLIVSGTGNWTR 337
D ++F I+ +V + S+H+LP L +W+P ++ + S TL I+ G
Sbjct: 146 DADVFRITLNPGSVITFVAELSSHNLPQLYLWEPE-AYKDMVNSYTLYRGILLGISGLLA 204
Query: 336 IPSTLL 319
+ T+L
Sbjct: 205 LFLTIL 210
>UniRef50_A5MC89 Cluster: Putative uncharacterized protein; n=1;
Streptococcus pneumoniae SP14-BS69|Rep: Putative
uncharacterized protein - Streptococcus pneumoniae
SP14-BS69
Length = 65
Score = 32.7 bits (71), Expect = 8.8
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Frame = +3
Query: 57 MARILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVG-DDPASHTYVRNKVEAAKF 233
M +I+DGKALA +++ +L +K A+ P + I+VG PA T+ + + +
Sbjct: 1 MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGIIQPAKSTFATRRGQLLRL 60
Query: 234 VGI 242
V +
Sbjct: 61 VPV 63
>UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin-1 -
Caenorhabditis elegans
Length = 3674
Score = 32.7 bits (71), Expect = 8.8
Identities = 17/52 (32%), Positives = 26/52 (50%)
Frame = +3
Query: 63 RILDGKALAMEIKKELKQKIAQWVGLGNRAPTIRCIIVGDDPASHTYVRNKV 218
R LD +A +KEL ++ + V L +RA I C + G P H +K+
Sbjct: 1734 RNLDDVDIAKSTRKELAERDSHIVSLTSRATAIHCALPGKGPQLHDVTLDKL 1785
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 733,943,092
Number of Sequences: 1657284
Number of extensions: 15132375
Number of successful extensions: 39772
Number of sequences better than 10.0: 119
Number of HSP's better than 10.0 without gapping: 37869
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 39691
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 54545459628
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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