Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NV120210.Seq
(733 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000F33553 Cluster: phosphoribosylaminoimidazole car... 140 2e-32
UniRef50_P22234 Cluster: Multifunctional protein ADE2 [Includes:... 140 4e-32
UniRef50_Q9VK80 Cluster: CG17024-PA; n=1; Drosophila melanogaste... 139 7e-32
UniRef50_A5UWC5 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 100 3e-20
UniRef50_Q6NRP1 Cluster: LOC431975 protein; n=2; Xenopus|Rep: LO... 81 3e-14
UniRef50_Q8ZCD2 Cluster: Phosphoribosylaminoimidazole-succinocar... 68 2e-10
UniRef50_Q5FIU8 Cluster: Phosphoribosylaminoimidazole-succinocar... 67 4e-10
UniRef50_P0A7E0 Cluster: Phosphoribosylaminoimidazole-succinocar... 66 8e-10
UniRef50_Q8ES99 Cluster: Phosphoribosylaminoimidazole-succinocar... 66 8e-10
UniRef50_Q87Y59 Cluster: Phosphoribosylaminoimidazole-succinocar... 65 1e-09
UniRef50_Q466M0 Cluster: Phosphoribosylaminoimidazole carboxylas... 63 8e-09
UniRef50_Q4J8G0 Cluster: Phosphoribosylaminoimidazole-succinocar... 62 1e-08
UniRef50_Q7M9X5 Cluster: Phosphoribosylaminoimidazole-succinocar... 61 2e-08
UniRef50_O57978 Cluster: Phosphoribosylaminoimidazole-succinocar... 59 1e-07
UniRef50_P12046 Cluster: Phosphoribosylaminoimidazole-succinocar... 58 2e-07
UniRef50_Q58987 Cluster: Phosphoribosylaminoimidazole-succinocar... 57 4e-07
UniRef50_Q49WJ0 Cluster: Phosphoribosylaminoimidazole-succinocar... 56 7e-07
UniRef50_A6QAA3 Cluster: Phosphoribosylaminoimidazole-succinocar... 56 7e-07
UniRef50_Q92AN6 Cluster: Phosphoribosylaminoimidazole-succinocar... 56 1e-06
UniRef50_Q3YRB0 Cluster: SAICAR synthetase; n=2; Anaplasmataceae... 55 2e-06
UniRef50_Q8TX83 Cluster: Phosphoribosylaminoimidazole-succinocar... 55 2e-06
UniRef50_A3H6Y2 Cluster: Phosphoribosylaminoimidazole-succinocar... 54 3e-06
UniRef50_UPI00015BB105 Cluster: phosphoribosylaminoimidazole-suc... 54 4e-06
UniRef50_Q7VAN8 Cluster: Phosphoribosylaminoimidazole-succinocar... 54 4e-06
UniRef50_Q8G5A9 Cluster: Phosphoribosylaminoimidazole-succinocar... 54 4e-06
UniRef50_Q7V5X1 Cluster: Phosphoribosylaminoimidazole-succinocar... 52 1e-05
UniRef50_A4M8A0 Cluster: Phosphoribosylaminoimidazole-succinocar... 51 3e-05
UniRef50_Q03Y92 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 50 4e-05
UniRef50_P73471 Cluster: Phosphoribosylaminoimidazole-succinocar... 50 6e-05
UniRef50_Q88U22 Cluster: Phosphoribosylaminoimidazole-succinocar... 50 8e-05
UniRef50_Q98NM8 Cluster: Phosphoribosylaminoimidazole-succinocar... 49 1e-04
UniRef50_Q6LZT3 Cluster: Phosphoribosylaminoimidazole-succinocar... 48 2e-04
UniRef50_Q9X0X0 Cluster: Phosphoribosylaminoimidazole-succinocar... 48 3e-04
UniRef50_Q8ZZK5 Cluster: Phosphoribosylaminoimidazole-succinocar... 48 3e-04
UniRef50_Q9RXT0 Cluster: Phosphoribosylaminoimidazole-succinocar... 47 4e-04
UniRef50_A4SAQ9 Cluster: Phosphoribosylaminoimidazole-succinocar... 46 0.001
UniRef50_O28997 Cluster: Phosphoribosylaminoimidazole carboxylas... 46 0.001
UniRef50_Q5JD27 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 44 0.004
UniRef50_Q73PW0 Cluster: Phosphoribosylaminoimidazole-succinocar... 44 0.005
UniRef50_Q73PV9 Cluster: Phosphoribosylaminoimidazole carboxylas... 43 0.009
UniRef50_Q8TIS9 Cluster: Phosphoribosylaminoimidazole-succinocar... 42 0.016
UniRef50_A7CZ13 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 42 0.021
UniRef50_A0RW02 Cluster: Phosphoribosylaminoimidazole-succinocar... 42 0.021
UniRef50_Q3WE59 Cluster: SAICAR synthetase; n=5; Bacteria|Rep: S... 41 0.036
UniRef50_Q7UJ19 Cluster: Phosphoribosylaminoimidazole-succinocar... 39 0.11
UniRef50_P38025 Cluster: Phosphoribosylaminoimidazole-succinocar... 39 0.11
UniRef50_Q1MRH1 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 39 0.15
UniRef50_A1G3E0 Cluster: SAICAR synthetase; n=1; Salinispora are... 38 0.19
UniRef50_P43060 Cluster: Phosphoribosylaminoimidazole-succinocar... 38 0.19
UniRef50_Q648Z8 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 38 0.25
UniRef50_Q9C1J4 Cluster: Phosphoribosylaminoimidazole-succinocar... 38 0.33
UniRef50_P46970 Cluster: Nonsense-mediated mRNA decay protein 5;... 37 0.44
UniRef50_Q1IPE1 Cluster: Phosphoribosylaminoimidazole-succinocar... 37 0.59
UniRef50_Q98I23 Cluster: Putative phosphoribosylaminoimidazole-s... 36 0.77
UniRef50_Q3Z881 Cluster: Phosphoribosylaminoimidazole-succinocar... 36 1.4
UniRef50_Q1MPV1 Cluster: Phosphoribosylcarboxyaminoimidazole (NC... 36 1.4
UniRef50_Q8F0I0 Cluster: Phosphoribosylaminoimidazole-succinocar... 36 1.4
UniRef50_Q8AAD6 Cluster: Indole-3-glycerol phosphate synthase; n... 35 1.8
UniRef50_Q2NEA3 Cluster: PurE; n=3; Archaea|Rep: PurE - Methanos... 35 2.4
UniRef50_Q4UML8 Cluster: Phosphoribosylaminoimidazole-succinocar... 35 2.4
UniRef50_Q0AXN6 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 34 3.1
UniRef50_A0Q508 Cluster: Phosphoribosylaminoimidazole-succinocar... 34 3.1
UniRef50_P41654 Cluster: Probable phosphoribosylaminoimidazole c... 34 3.1
UniRef50_Q9YBE5 Cluster: PqqE homolog; n=4; Thermoprotei|Rep: Pq... 33 9.5
UniRef50_A7DSW8 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 33 9.5
UniRef50_Q895U7 Cluster: Phosphoribosylaminoimidazole-succinocar... 33 9.5
>UniRef50_UPI0000F33553 Cluster: phosphoribosylaminoimidazole
carboxylase, phosphoribosylaminoimidazole
succinocarboxamide synthetase; n=2; Coelomata|Rep:
phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoimidazole succinocarboxamide
synthetase - Bos Taurus
Length = 402
Score = 140 bits (340), Expect = 2e-32
Identities = 62/83 (74%), Positives = 71/83 (85%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ AGIKTAF K ETAF++ KCEMIPIEWV RR+ATGSFLKRNPGV EG++F PPK E
Sbjct: 71 LQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVE 130
Query: 181 TFFKDDANHDPQWSEEQIISAKF 249
FFKDDAN+DPQWSEEQ+I+A F
Sbjct: 131 MFFKDDANNDPQWSEEQLIAANF 153
Score = 113 bits (271), Expect = 6e-24
Identities = 55/85 (64%), Positives = 64/85 (75%), Gaps = 1/85 (1%)
Frame = +3
Query: 258 GLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDT-EGSIVLADVIDSDS 434
GL+IG+ EVD M AT IFEILEK+W ++C L+DMKIEFGVD IVLADVID+DS
Sbjct: 157 GLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVITREIVLADVIDNDS 216
Query: 435 WRLWPSGDKRLMVDKQVYRNLTTVT 509
WRLWPSGD+ DKQ YR+L VT
Sbjct: 217 WRLWPSGDRSQQKDKQSYRDLKEVT 241
>UniRef50_P22234 Cluster: Multifunctional protein ADE2 [Includes:
Phosphoribosylaminoimidazole- succinocarboxamide
synthase (EC 6.3.2.6) (SAICAR synthetase);
Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21)
(AIR carboxylase) (AIRC)]; n=60; Eumetazoa|Rep:
Multifunctional protein ADE2 [Includes:
Phosphoribosylaminoimidazole- succinocarboxamide
synthase (EC 6.3.2.6) (SAICAR synthetase);
Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21)
(AIR carboxylase) (AIRC)] - Homo sapiens (Human)
Length = 425
Score = 140 bits (338), Expect = 4e-32
Identities = 61/83 (73%), Positives = 72/83 (86%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ AGIKTAF + ETAF++ +CEMIPIEWV RR+ATGSFLKRNPGV EG++F PPK E
Sbjct: 68 LQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVE 127
Query: 181 TFFKDDANHDPQWSEEQIISAKF 249
FFKDDAN+DPQWSEEQ+I+AKF
Sbjct: 128 LFFKDDANNDPQWSEEQLIAAKF 150
Score = 116 bits (279), Expect = 6e-25
Identities = 57/85 (67%), Positives = 65/85 (76%), Gaps = 1/85 (1%)
Frame = +3
Query: 258 GLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVD-TEGSIVLADVIDSDS 434
GLLIG+ EVD M AT IFEILEK+W ++C L+DMKIEFGVD T IVLADVID+DS
Sbjct: 154 GLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDS 213
Query: 435 WRLWPSGDKRLMVDKQVYRNLTTVT 509
WRLWPSGD+ DKQ YR+L VT
Sbjct: 214 WRLWPSGDRSQQKDKQSYRDLKEVT 238
Score = 73.3 bits (172), Expect = 6e-12
Identities = 36/71 (50%), Positives = 47/71 (66%), Gaps = 1/71 (1%)
Frame = +2
Query: 518 LDTVKRNFAWVKDQLDFL-KPTIHHKVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTS 694
L VK+NF WV ++++ L K +VVV MGS +D HC+KI KA G+ +LRVTS
Sbjct: 242 LQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTS 301
Query: 695 AHKATEETLRI 727
AHK +ETLRI
Sbjct: 302 AHKGPDETLRI 312
>UniRef50_Q9VK80 Cluster: CG17024-PA; n=1; Drosophila
melanogaster|Rep: CG17024-PA - Drosophila melanogaster
(Fruit fly)
Length = 395
Score = 139 bits (336), Expect = 7e-32
Identities = 57/90 (63%), Positives = 77/90 (85%)
Frame = +3
Query: 240 SQIQLNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADV 419
S + NGL+IG DEV MR+ ++++FE+LE+AW ++CAL+DMK+EFGVD +G+I+LAD+
Sbjct: 150 SNFECNGLIIGADEVQIMRRTSLVVFEVLERAWKTKNCALVDMKVEFGVDEDGNILLADI 209
Query: 420 IDSDSWRLWPSGDKRLMVDKQVYRNLTTVT 509
IDSD+WR+WP+GDKRLMVDK VY NL TVT
Sbjct: 210 IDSDTWRIWPAGDKRLMVDKTVYINLDTVT 239
Score = 127 bits (306), Expect = 3e-28
Identities = 53/83 (63%), Positives = 68/83 (81%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L AGI+TA+V + AF+++KC+M+ IEWVTRRLATGSF+K NP VPEG+RF PPKQE
Sbjct: 70 LNEAGIRTAYVDQCGDNAFIARKCQMVHIEWVTRRLATGSFIKLNPEVPEGYRFAPPKQE 129
Query: 181 TFFKDDANHDPQWSEEQIISAKF 249
T FKDD++HDP W +EQI+S+ F
Sbjct: 130 TCFKDDSSHDPLWCDEQILSSNF 152
Score = 37.1 bits (82), Expect = 0.44
Identities = 15/30 (50%), Positives = 22/30 (73%)
Frame = +2
Query: 512 ADLDTVKRNFAWVKDQLDFLKPTIHHKVVV 601
+DL+TVKRN++WV +QL + P H VV+
Sbjct: 241 SDLNTVKRNYSWVIEQLSSIAPPQDHLVVI 270
>UniRef50_A5UWC5 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=5; Chloroflexi (class)|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Roseiflexus sp. RS-1
Length = 249
Score = 100 bits (240), Expect = 3e-20
Identities = 43/78 (55%), Positives = 58/78 (74%)
Frame = +3
Query: 276 DEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSG 455
DEV+ M + +F ++E+AWA +D L D+KIEFG DT G +++ADVID+DSWR+WP G
Sbjct: 148 DEVEQMASESRRVFLLIEEAWAAQDVVLCDLKIEFGRDTSGRLLVADVIDNDSWRIWPGG 207
Query: 456 DKRLMVDKQVYRNLTTVT 509
K M+DKQVYRN+ VT
Sbjct: 208 VKERMLDKQVYRNMPVVT 225
Score = 89.0 bits (211), Expect = 1e-16
Identities = 40/80 (50%), Positives = 53/80 (66%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L AG+ T FV + + +C MIP+E V RR+ATGS+++RNP V EG RF PP E
Sbjct: 62 LNRAGVATHFVAAPEPSVMVVYRCAMIPLEVVNRRIATGSYIRRNPDVAEGTRFDPPLLE 121
Query: 181 TFFKDDANHDPQWSEEQIIS 240
F KDDA HDPQ + ++II+
Sbjct: 122 FFLKDDARHDPQMTPDEIIA 141
>UniRef50_Q6NRP1 Cluster: LOC431975 protein; n=2; Xenopus|Rep:
LOC431975 protein - Xenopus laevis (African clawed frog)
Length = 371
Score = 81.0 bits (191), Expect = 3e-14
Identities = 43/83 (51%), Positives = 57/83 (68%), Gaps = 1/83 (1%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ AGIKTAFVK SE AF++ +CEMIPIEW R++ TG RN EG+RF+ PK E
Sbjct: 143 LQEAGIKTAFVKRCSEAAFIATQCEMIPIEWFCRKIPTG----RNTETDEGYRFSQPKVE 198
Query: 181 TFFKDD-ANHDPQWSEEQIISAK 246
+ DD +NH Q S+EQ+++ K
Sbjct: 199 MYKVDDTSNH--QLSKEQLMAVK 219
Score = 80.6 bits (190), Expect = 4e-14
Identities = 40/69 (57%), Positives = 51/69 (73%), Gaps = 1/69 (1%)
Frame = +3
Query: 258 GLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVD-TEGSIVLADVIDSDS 434
GLLIG+ EVD M ++TI IFEI+EKAW +DC L+DM+I+FGVD T+ I+L D I S
Sbjct: 224 GLLIGKMEVDVMTRSTIAIFEIIEKAWRAQDCTLVDMRIKFGVDVTKKEILLTD-IKCGS 282
Query: 435 WRLWPSGDK 461
LWP G+K
Sbjct: 283 QALWPLGNK 291
Score = 46.0 bits (104), Expect = 0.001
Identities = 20/47 (42%), Positives = 31/47 (65%)
Frame = +2
Query: 590 KVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIM 730
+VV+ M S +D HC++I K+ + G+ +LRV SAH +ETL I+
Sbjct: 305 RVVLLMESTSDLAHCEEIKKSCTKYGMKCELRVASAHTGPQETLDIL 351
>UniRef50_Q8ZCD2 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=17; Enterobacteriaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Yersinia pestis
Length = 237
Score = 68.1 bits (159), Expect = 2e-10
Identities = 35/75 (46%), Positives = 45/75 (60%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ AGI T ++ S+T L KK EMIP+E V R A GS +KR G+ EG PP +
Sbjct: 61 LEEAGIPTQMERLLSDTEVLVKKLEMIPVECVIRNRAAGSLVKR-LGIEEGLSLNPPLFD 119
Query: 181 TFFKDDANHDPQWSE 225
F K+DA HDP +E
Sbjct: 120 LFLKNDAMHDPMVNE 134
Score = 38.7 bits (86), Expect = 0.15
Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 2/69 (2%)
Frame = +3
Query: 291 MRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLM 470
M++ + L ++L K + L+D K+EFG+ G +VL D D RLW DK+ +
Sbjct: 151 MKELSYLANDVLSKLFDDAGLILVDFKLEFGL-FNGEVVLGDEFSPDGSRLW---DKKTL 206
Query: 471 --VDKQVYR 491
+DK YR
Sbjct: 207 NKMDKDRYR 215
>UniRef50_Q5FIU8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamidesynthase;
n=6; Lactobacillus|Rep:
Phosphoribosylaminoimidazole-succinocarboxamidesynthase
- Lactobacillus acidophilus
Length = 238
Score = 67.3 bits (157), Expect = 4e-10
Identities = 36/80 (45%), Positives = 46/80 (57%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L GI T F+K S+T L KKCEM P+E VTR +A G F R G+ EG +F P +E
Sbjct: 59 LAKNGIPTHFIKKISDTEELVKKCEMFPLEVVTRNIAAGHFSSRY-GMGEGEKFDTPVEE 117
Query: 181 TFFKDDANHDPQWSEEQIIS 240
F+K D DP +E I+
Sbjct: 118 LFYKSDELDDPIMNESDAIA 137
Score = 50.4 bits (115), Expect = 4e-05
Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 4/75 (5%)
Frame = +3
Query: 294 RKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMV 473
R+ L+ + +KA L+D K+EFG D +G+I+LAD D+ RLW K M
Sbjct: 154 RQVNKLLIPLFDKA----GMELVDFKLEFGKDADGNIILADEFSPDNCRLWDKKTKEHM- 208
Query: 474 DKQVYR----NLTTV 506
DK VYR +LTTV
Sbjct: 209 DKDVYRRDIGDLTTV 223
>UniRef50_P0A7E0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=50; Proteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Shigella flexneri
Length = 237
Score = 66.1 bits (154), Expect = 8e-10
Identities = 33/75 (44%), Positives = 44/75 (58%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L AGI T ++ S+T L KK +M+P+E V R A GS +KR G+ EG PP +
Sbjct: 61 LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFD 119
Query: 181 TFFKDDANHDPQWSE 225
F K+DA HDP +E
Sbjct: 120 LFLKNDAMHDPMVNE 134
Score = 38.3 bits (85), Expect = 0.19
Identities = 22/75 (29%), Positives = 38/75 (50%)
Frame = +3
Query: 267 IGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLW 446
+ ++ + M++ T ++L+K + L+D K+EFG+ +G +VL D D RLW
Sbjct: 143 VSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YKGEVVLGDEFSPDGSRLW 201
Query: 447 PSGDKRLMVDKQVYR 491
M DK +R
Sbjct: 202 DKETLEKM-DKDRFR 215
>UniRef50_Q8ES99 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=10; Firmicutes|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Oceanobacillus iheyensis
Length = 237
Score = 66.1 bits (154), Expect = 8e-10
Identities = 36/79 (45%), Positives = 46/79 (58%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L AGI T F+K T + +K +IP+E V R LATGS KR G+ E FTPP E
Sbjct: 61 LHEAGISTHFIKRLDSTQQIVQKTSIIPLEVVIRNLATGSITKR-LGIKEKVSFTPPLLE 119
Query: 181 TFFKDDANHDPQWSEEQII 237
F+KDDA DP ++E +
Sbjct: 120 LFYKDDALGDPLINDEHAL 138
Score = 40.7 bits (91), Expect = 0.036
Identities = 19/48 (39%), Positives = 30/48 (62%)
Frame = +3
Query: 357 LIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYRNLT 500
L+D K+EFG + +G I+L+D + D+ RLW + +DK V+R T
Sbjct: 173 LVDFKLEFGRNKDGEILLSDEVSPDTCRLWDI-ETNEKLDKDVFRQGT 219
>UniRef50_Q87Y59 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=12; Gammaproteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pseudomonas syringae pv. tomato
Length = 236
Score = 65.3 bits (152), Expect = 1e-09
Identities = 34/80 (42%), Positives = 46/80 (57%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ AGI T F K+ + L KK +MIP+E V R A GS +KR G+ EG + P E
Sbjct: 61 LEEAGIPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKR-LGIEEGTKLNPYTFE 119
Query: 181 TFFKDDANHDPQWSEEQIIS 240
F KDDA DP +E +++
Sbjct: 120 LFLKDDAKGDPFINESHVVA 139
Score = 44.8 bits (101), Expect = 0.002
Identities = 26/67 (38%), Positives = 36/67 (53%)
Frame = +3
Query: 291 MRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLM 470
M++ +I + E+L K + L+D K+EFGV G IVL D D RLW D R
Sbjct: 151 MKELSIKVNEVLTKLFDDAGLLLVDFKLEFGV-FHGEIVLGDEFSPDGCRLWDK-DTRKK 208
Query: 471 VDKQVYR 491
+DK +R
Sbjct: 209 MDKDRFR 215
>UniRef50_Q466M0 Cluster: Phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoribosylaminoimidazole
succinocarboxamide synthetase; n=3; Archaea|Rep:
Phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoribosylaminoimidazole
succinocarboxamide synthetase - Methanosarcina barkeri
(strain Fusaro / DSM 804)
Length = 296
Score = 62.9 bits (146), Expect = 8e-09
Identities = 38/99 (38%), Positives = 59/99 (59%), Gaps = 7/99 (7%)
Frame = +3
Query: 273 RDEVDYMRKATIL-IFEILEKAW-----ALRDCALIDMKIEFGVDTEGS-IVLADVIDSD 431
++E+DY+ +A +L F LE AW L+D+KIE G + + IV+ADVID+D
Sbjct: 195 QEELDYIVQAIMLPTFLALEDAWRKIMTTYGPMELVDLKIEVGRRLDNNRIVIADVIDND 254
Query: 432 SWRLWPSGDKRLMVDKQVYRNLTTVTQLI*TQSNATLLG 548
SWR+W G+ +DKQ +R+ + Q+ ++ ATL G
Sbjct: 255 SWRIWSGGNPEKQLDKQCFRDGNPLDQV--AENYATLAG 291
Score = 54.4 bits (125), Expect = 3e-06
Identities = 30/68 (44%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNP--GVPEG--FRFTP 168
L G+ TAF++ S L +CEM+P+E V RR A GS+L+R+P G EG +RF
Sbjct: 57 LNRKGLPTAFIERTSPNTLLCYQCEMLPLELVVRRYAWGSYLQRHPEYGNQEGTAYRFDE 116
Query: 169 PKQETFFK 192
P E F K
Sbjct: 117 PVWEIFHK 124
>UniRef50_Q4J8G0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Sulfolobaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Sulfolobus acidocaldarius
Length = 235
Score = 62.1 bits (144), Expect = 1e-08
Identities = 32/71 (45%), Positives = 42/71 (59%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ I+T +V + E + K +MIP+E V R +ATGS +KR P + EG F PP E
Sbjct: 59 LEKNDIRTHYVGMYDEKTMIVTKLKMIPVEVVLRNIATGSIVKRLP-IKEGEVFDPPIVE 117
Query: 181 TFFKDDANHDP 213
F KDD HDP
Sbjct: 118 FFLKDDLRHDP 128
Score = 43.6 bits (98), Expect = 0.005
Identities = 23/86 (26%), Positives = 46/86 (53%)
Frame = +3
Query: 234 HFSQIQLNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLA 413
++S +Q LL R E + + + + + +++ R L D+K+EFG D + ++++
Sbjct: 131 NYSHLQYFNLLT-RKEAEIVEEVIVKVNAVMKNFLKERGLVLYDLKLEFGKDKDNNLIVG 189
Query: 414 DVIDSDSWRLWPSGDKRLMVDKQVYR 491
D I DS R+ +++ DK +YR
Sbjct: 190 DEITLDSMRVRDEKTNKIL-DKDLYR 214
>UniRef50_Q7M9X5 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=18; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Wolinella succinogenes
Length = 236
Score = 61.3 bits (142), Expect = 2e-08
Identities = 36/82 (43%), Positives = 47/82 (57%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L++ GIKT F+K E L K+ +IPIE VTR +ATGS KR G+ EG E
Sbjct: 61 LEAEGIKTHFIKQLDEKNMLCKRVSIIPIEVVTRNIATGSLSKR-LGIKEGSVLPFSLVE 119
Query: 181 TFFKDDANHDPQWSEEQIISAK 246
++KDDA DP ++E I K
Sbjct: 120 FYYKDDALGDPIMNDEHAILLK 141
Score = 51.2 bits (117), Expect = 3e-05
Identities = 26/73 (35%), Positives = 42/73 (57%)
Frame = +3
Query: 273 RDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPS 452
++E++++++ I EIL + + L+D K+EFG D EG+I+LAD I DS R W
Sbjct: 146 QEELEFLKETAREINEILRSFFDSKGLNLVDFKLEFGKDIEGNILLADEISPDSCRFWDK 205
Query: 453 GDKRLMVDKQVYR 491
+DK +R
Sbjct: 206 KTNE-KLDKDRFR 217
>UniRef50_O57978 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=6; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pyrococcus horikoshii
Length = 238
Score = 58.8 bits (136), Expect = 1e-07
Identities = 28/71 (39%), Positives = 41/71 (57%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ GIKT F+ +A + +K +M P+E V R + GS KR P +PEG+ P E
Sbjct: 60 LEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVE 118
Query: 181 TFFKDDANHDP 213
++K+D HDP
Sbjct: 119 LYYKNDELHDP 129
Score = 57.6 bits (133), Expect = 3e-07
Identities = 30/75 (40%), Positives = 43/75 (57%)
Frame = +3
Query: 267 IGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLW 446
I DE+ + + + + EIL+ A + L+D K+EFG D G IVLAD I D+ R W
Sbjct: 141 ISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFW 200
Query: 447 PSGDKRLMVDKQVYR 491
+ KR +DK V+R
Sbjct: 201 DAKTKR-SLDKDVFR 214
>UniRef50_P12046 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=61; Bacilli|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Bacillus subtilis
Length = 241
Score = 58.4 bits (135), Expect = 2e-07
Identities = 32/78 (41%), Positives = 44/78 (56%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L + GI F++ SET L KK ++P+E V R + GS KR G+PEG P E
Sbjct: 63 LHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGSMSKR-LGIPEGTELEQPIIE 121
Query: 181 TFFKDDANHDPQWSEEQI 234
++KDDA DP +E+ I
Sbjct: 122 FYYKDDALGDPLITEDHI 139
Score = 53.2 bits (122), Expect = 6e-06
Identities = 28/79 (35%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Frame = +3
Query: 276 DEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSG 455
++V+ ++ T ++ E L+ + LID K+EFG+D EG ++LAD I D+ RLW
Sbjct: 148 EQVETIKSITTIVNEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDK- 206
Query: 456 DKRLMVDKQVY-RNLTTVT 509
+ +DK ++ RNL ++T
Sbjct: 207 ETNEKLDKDLFRRNLGSLT 225
>UniRef50_Q58987 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=5; Euryarchaeota|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanococcus jannaschii
Length = 242
Score = 57.2 bits (132), Expect = 4e-07
Identities = 27/76 (35%), Positives = 49/76 (64%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
L R+E++ +++ + + E+L+K + + L+D KIE G D EG++++AD I D+ RL
Sbjct: 148 LATREELNKIKEIALKVNEVLKKLFDEKGIILVDFKIEIGKDREGNLLVADEISPDTMRL 207
Query: 444 WPSGDKRLMVDKQVYR 491
W + R ++DK V+R
Sbjct: 208 WDK-ETRDVLDKDVFR 222
Score = 49.6 bits (113), Expect = 8e-05
Identities = 26/76 (34%), Positives = 41/76 (53%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ G+KT ++K ++KK E+IPIE + R +A GS +R P EG P +
Sbjct: 67 LEENGVKTHYIKYIEPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYP-FEEGKELPFPIVQ 125
Query: 181 TFFKDDANHDPQWSEE 228
+K+D DP +E+
Sbjct: 126 FDYKNDEYGDPMLNED 141
>UniRef50_Q49WJ0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Staphylococcus saprophyticus subsp.
saprophyticus ATCC 15305|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Staphylococcus saprophyticus subsp. saprophyticus
(strain ATCC 15305 /DSM 20229)
Length = 233
Score = 56.4 bits (130), Expect = 7e-07
Identities = 31/78 (39%), Positives = 45/78 (57%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
LK+ G+ + F++ SET L E+IP+E V R +A GS KR G +G F P E
Sbjct: 58 LKAKGLNSHFIEQISETEQLVNSVEIIPLEVVVRNIAAGSITKR-LGFEKGHTFETPLVE 116
Query: 181 TFFKDDANHDPQWSEEQI 234
F+K+D +DP +E+ I
Sbjct: 117 FFYKNDDLNDPLITEDHI 134
Score = 50.8 bits (116), Expect = 3e-05
Identities = 31/81 (38%), Positives = 42/81 (51%), Gaps = 1/81 (1%)
Frame = +3
Query: 261 LLIGRD-EVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSW 437
L I D E++ +++A I E+L + L+D KIEFG EG I+LAD I D+
Sbjct: 137 LQIANDGEIEKLKEAATEINEVLVNLMDKMNLRLVDFKIEFGRTNEGEILLADEISPDTC 196
Query: 438 RLWPSGDKRLMVDKQVYRNLT 500
R+W DK VYR T
Sbjct: 197 RIWDK-QSDTNFDKDVYREDT 216
>UniRef50_A6QAA3 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=2; Epsilonproteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Sulfurovum sp. (strain NBC37-1)
Length = 244
Score = 56.4 bits (130), Expect = 7e-07
Identities = 28/71 (39%), Positives = 44/71 (61%)
Frame = +3
Query: 279 EVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGD 458
E+DY+R I ++L+ +A R+ L+D K+EFG D +G+I+L D + D++RLW S
Sbjct: 153 ELDYIRYMARRINDLLKAFYAQRNLTLVDFKLEFGRDMDGNIILIDELSPDNFRLWDSVS 212
Query: 459 KRLMVDKQVYR 491
M DK +R
Sbjct: 213 GESM-DKDRFR 222
>UniRef50_Q92AN6 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=17; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Listeria innocua
Length = 237
Score = 55.6 bits (128), Expect = 1e-06
Identities = 30/81 (37%), Positives = 50/81 (61%), Gaps = 1/81 (1%)
Frame = +3
Query: 276 DEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSG 455
+E+D +R+A I ++L++ + + LID K+EFG D G+I+LAD I D+ RLW
Sbjct: 145 NEMDTIRQAARSINKVLQELFNQMNITLIDFKLEFGRDAAGNILLADEISPDTCRLWDK- 203
Query: 456 DKRLMVDKQVY-RNLTTVTQL 515
+ +DK V+ RN+ +T +
Sbjct: 204 ETNQKLDKDVFRRNIGNLTDV 224
Score = 49.2 bits (112), Expect = 1e-04
Identities = 28/79 (35%), Positives = 42/79 (53%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L GI + F++ SET L K+ +IP+E V R + GS KR G EG E
Sbjct: 60 LAKEGISSHFIRAISETEQLVKEVSIIPLEVVVRNVMAGSLAKR-LGKEEGEEIPNAIVE 118
Query: 181 TFFKDDANHDPQWSEEQII 237
++KDDA DP +++ ++
Sbjct: 119 FYYKDDALDDPFINDDHVL 137
>UniRef50_Q3YRB0 Cluster: SAICAR synthetase; n=2;
Anaplasmataceae|Rep: SAICAR synthetase - Ehrlichia canis
(strain Jake)
Length = 258
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/80 (37%), Positives = 45/80 (56%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L + GIKT F+ + ++ L KK +IP+E V R L+ G+F KR + +G F P E
Sbjct: 70 LTNKGIKTHFISLLNQREQLVKKVSIIPLEIVVRNLSAGNFSKRFQ-IADGTSFKSPIIE 128
Query: 181 TFFKDDANHDPQWSEEQIIS 240
++K D DP S+ I+S
Sbjct: 129 FYYKSDKLSDPMVSDGHILS 148
Score = 43.2 bits (97), Expect = 0.007
Identities = 28/82 (34%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
Frame = +3
Query: 279 EVDYMRKATILIFEILEKAWALRDCALIDMKIEFGV---DTEGSIVLADVIDSDSWRLWP 449
E++ ++ ++ I EIL + + L+D K+EFG + ++LAD I D+ RLW
Sbjct: 156 ELEKIKMLSLKINEILSEIFLNVGIKLVDFKLEFGKLYNNKASDLLLADEISPDTCRLWN 215
Query: 450 SGDKRLMVDKQVYR-NLTTVTQ 512
D R +DK +YR NL V +
Sbjct: 216 ISDNR-KLDKDLYRMNLGNVIE 236
>UniRef50_Q8TX83 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=6; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanopyrus kandleri
Length = 247
Score = 54.8 bits (126), Expect = 2e-06
Identities = 26/76 (34%), Positives = 44/76 (57%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
L +EV+ MR+ T+ + E+L + D L+D K+EFGV+ +G +V+ D I D+ R
Sbjct: 143 LATEEEVERMRELTLQVNEVLSEFLKDCDIILVDFKLEFGVNPDGEVVVGDEISPDTCRF 202
Query: 444 WPSGDKRLMVDKQVYR 491
W + +DK ++R
Sbjct: 203 W-DAETEESLDKDIFR 217
Score = 50.8 bits (116), Expect = 3e-05
Identities = 27/78 (34%), Positives = 44/78 (56%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ AGI T +V++A E + ++ +M +E + R +ATGS ++R P EG + PP E
Sbjct: 62 LEDAGIPTHYVELADERRMVVERLDMFNLEVICRNMATGSLVERLP-FEEGEKLDPPIVE 120
Query: 181 TFFKDDANHDPQWSEEQI 234
+K D DP + + I
Sbjct: 121 FDYKSDEYGDPMVNMDHI 138
>UniRef50_A3H6Y2 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Caldivirga maquilingensis IC-167|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Caldivirga maquilingensis IC-167
Length = 241
Score = 54.4 bits (125), Expect = 3e-06
Identities = 28/81 (34%), Positives = 42/81 (51%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L +G++T F+ + ++ MIP+E + R A GSF++R P + +FT P E
Sbjct: 62 LNESGVRTHFINWDGDRRIHVRRLRMIPVEVIVRNYAYGSFIRRMPLIKPLTKFTTPLVE 121
Query: 181 TFFKDDANHDPQWSEEQIISA 243
K+D HDP E II A
Sbjct: 122 FHLKNDELHDPLILIEDIIEA 142
Score = 47.6 bits (108), Expect = 3e-04
Identities = 27/85 (31%), Positives = 50/85 (58%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
L ++V +R ++ + +L + L+D K+EFGV++ G++VLAD + D+ R+
Sbjct: 144 LTSMEQVMEIRSVSLKVNHLLSELLGKYGLTLVDFKLEFGVNSNGALVLADELSGDTMRV 203
Query: 444 WPSGDKRLMVDKQVYRNLTTVTQLI 518
+G K L DK+++R +V +LI
Sbjct: 204 LMNG-KHL--DKELFRMGGSVKELI 225
>UniRef50_UPI00015BB105 Cluster:
phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Ignicoccus hospitalis KIN4/I|Rep:
phosphoribosylaminoimidazole-succinocarboxamide synthase
- Ignicoccus hospitalis KIN4/I
Length = 235
Score = 54.0 bits (124), Expect = 4e-06
Identities = 28/81 (34%), Positives = 46/81 (56%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ G+KT F+ +E ++ K + +P+E++ R A GS LKR P + +G R P E
Sbjct: 56 LEQHGVKTHFLS-RNEDEIVAIKTKPLPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFE 114
Query: 181 TFFKDDANHDPQWSEEQIISA 243
+K D HDP +E+ ++A
Sbjct: 115 VHYKSDELHDPLLAEDDPVAA 135
Score = 46.8 bits (106), Expect = 5e-04
Identities = 22/76 (28%), Positives = 43/76 (56%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
++ +D + +R+ T+ + E+L + + LID K+E+G+ +G +VL D + DS+R
Sbjct: 137 IVSKDVMKTIRETTLKVNELLTELFEKAGFKLIDFKVEYGITEDGRVVLIDELSPDSFRA 196
Query: 444 WPSGDKRLMVDKQVYR 491
G+ DK ++R
Sbjct: 197 HKGGE---AYDKDLFR 209
>UniRef50_Q7VAN8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=9; Prochlorococcus marinus|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Prochlorococcus marinus
Length = 244
Score = 54.0 bits (124), Expect = 4e-06
Identities = 28/78 (35%), Positives = 44/78 (56%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ GI T F+ + + L ++ ++IPIE V R +A+GS K+ P P G + P +
Sbjct: 63 LERNGIATHFLNLEDDCWMLVQRVDVIPIEIVIRNIASGSLCKQTPIAP-GTELSRPLMD 121
Query: 181 TFFKDDANHDPQWSEEQI 234
+ KDD DP +EE+I
Sbjct: 122 LYLKDDVLEDPLLTEERI 139
Score = 37.5 bits (83), Expect = 0.33
Identities = 16/61 (26%), Positives = 34/61 (55%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
L+ + +++ ++ + + L++ D L+D K+E G + G +++AD I DS R+
Sbjct: 144 LLSSSQRKEIQRLSLRVNDCLKEFMKGLDLLLVDFKLEMGFNGSGQLLIADEISPDSCRI 203
Query: 444 W 446
W
Sbjct: 204 W 204
>UniRef50_Q8G5A9 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=5; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Bifidobacterium longum
Length = 250
Score = 54.0 bits (124), Expect = 4e-06
Identities = 29/80 (36%), Positives = 42/80 (52%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
LK GI + +K +T L +K M P+E V R +A G F R GV EG P E
Sbjct: 61 LKKRGIDSHLIKRVDDTGQLVRKVNMFPLEIVLRNVAAGHFCSRL-GVEEGLPLKEPVLE 119
Query: 181 TFFKDDANHDPQWSEEQIIS 240
F K+D HDP +++ +++
Sbjct: 120 YFLKNDDLHDPFVNDDDLVA 139
Score = 45.6 bits (103), Expect = 0.001
Identities = 27/63 (42%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Frame = +3
Query: 312 IFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGD---KRLMVDKQ 482
I E L + +A D L+D KIE G T+G+++LAD I DS RLW D K +DK
Sbjct: 158 INEALIEIFAKIDVKLVDFKIEMGRATDGTLLLADEITPDSCRLWDQKDHSGKVEHLDKD 217
Query: 483 VYR 491
++R
Sbjct: 218 LFR 220
>UniRef50_Q7V5X1 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=15; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Prochlorococcus marinus (strain MIT 9313)
Length = 242
Score = 52.4 bits (120), Expect = 1e-05
Identities = 26/78 (33%), Positives = 45/78 (57%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ G+ T ++ + SET L + ++IP+E V R +ATGS ++ P + G +P +
Sbjct: 63 LEREGVPTHYLDLVSETWMLVQHVDVIPLEVVIRNVATGSLCQQTP-IAAGTELSPALLD 121
Query: 181 TFFKDDANHDPQWSEEQI 234
++KDD DP SE ++
Sbjct: 122 LYYKDDNLGDPLLSESRL 139
Score = 43.6 bits (98), Expect = 0.005
Identities = 25/87 (28%), Positives = 50/87 (57%), Gaps = 3/87 (3%)
Frame = +3
Query: 240 SQIQLNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADV 419
S++QL GL+ + ++ + A + ++L + D L+D K+E G+++ G++++AD
Sbjct: 137 SRLQLLGLISSQQRLEIEQLAR-RVNQLLLSFFESLDLLLVDFKLELGLNSAGTLLVADE 195
Query: 420 IDSDSWRLWP---SGDKRLMVDKQVYR 491
I D+ RLW S + ++DK +R
Sbjct: 196 ISPDTCRLWDHRNSDPQARILDKDRFR 222
>UniRef50_A4M8A0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Petrotoga mobilis SJ95
Length = 238
Score = 50.8 bits (116), Expect = 3e-05
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L + GI T ++ E +F++K ++IP+E + R G F KR GV +G F P E
Sbjct: 63 LNNQGINTHYINDYDENSFVAKWTDLIPLEVIIRNYTAGGFCKRY-GVKKGLMFDYPLVE 121
Query: 181 TFFKDDANHDPQWSEEQIISAKF-N*TVF*SVATRSTT*EKLRF*YLKS 324
K+D DP +++ I+ K V +A+ S + YLKS
Sbjct: 122 FSLKNDELGDPMIAKDAILLLKITTENVLDEIASISKKVNNILSDYLKS 170
>UniRef50_Q03Y92 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase; n=4; Lactobacillales|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase - Leuconostoc mesenteroides subsp.
mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 249
Score = 50.4 bits (115), Expect = 4e-05
Identities = 28/83 (33%), Positives = 44/83 (53%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L GI+ ++ SET L +++PIE VTR A+G F+ + P + TP QE
Sbjct: 72 LTRQGIENHYLSSVSETDELDLALDILPIEVVTRNYASGHFVSKFNATPMQ-KLTPVVQE 130
Query: 181 TFFKDDANHDPQWSEEQIISAKF 249
++K D DP ++ QI++ F
Sbjct: 131 FYYKSDELDDPFMNDSQILALGF 153
Score = 39.1 bits (87), Expect = 0.11
Identities = 18/45 (40%), Positives = 29/45 (64%)
Frame = +3
Query: 357 LIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 491
L+D K+E+G D+EG ++LAD + D+ RL + +DK V+R
Sbjct: 184 LVDFKLEYGRDSEGKLILADELSPDNMRLVDQKTGK-SLDKDVFR 227
>UniRef50_P73471 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=19; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Synechocystis sp. (strain PCC 6803)
Length = 264
Score = 50.0 bits (114), Expect = 6e-05
Identities = 28/79 (35%), Positives = 41/79 (51%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L++ GI T ++ L K +IP+E V R +A GS K+ G+ EG P E
Sbjct: 74 LETLGIPTHYIDCPQNDQMLVKAVNIIPLEVVVRNIAAGSLCKQT-GLKEGLVLPNPLVE 132
Query: 181 TFFKDDANHDPQWSEEQII 237
+FKDDA DP + E+ +
Sbjct: 133 FYFKDDALGDPLLTWERAL 151
Score = 47.6 bits (108), Expect = 3e-04
Identities = 29/83 (34%), Positives = 48/83 (57%), Gaps = 6/83 (7%)
Frame = +3
Query: 261 LLIG-RDE--VDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSD 431
LL+G DE + ++ + I + L++ +A D L+D K+EFG D +G I+LAD I D
Sbjct: 151 LLLGVTDEARLQTLKDLALNINQHLQRFFAQCDITLVDFKLEFGGDRQGKIILADEISPD 210
Query: 432 SWRLWPSGD---KRLMVDKQVYR 491
+ RLW + + ++DK +R
Sbjct: 211 TCRLWDNAQADPQARVLDKDRFR 233
>UniRef50_Q88U22 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=3; Lactobacillales|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Lactobacillus plantarum
Length = 243
Score = 49.6 bits (113), Expect = 8e-05
Identities = 29/78 (37%), Positives = 42/78 (53%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L + GI F++ S+ L ++ MIP+E V R A+GSF +R VP +F P E
Sbjct: 65 LANHGIANHFIEQPSDYVQLVRRVTMIPLETVVRNAASGSF-ERKFAVPHLTKFAEPVLE 123
Query: 181 TFFKDDANHDPQWSEEQI 234
F+K D DP ++ QI
Sbjct: 124 FFYKSDQLDDPFINDSQI 141
Score = 41.5 bits (93), Expect = 0.021
Identities = 28/83 (33%), Positives = 45/83 (54%), Gaps = 4/83 (4%)
Frame = +3
Query: 291 MRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLM 470
+++ + + + L +A L+D KIEFG+ T G ++LAD I DS RL
Sbjct: 155 IKRQALQVNQRLTAIFAAMGVQLVDFKIEFGLTTTGKVLLADEISPDSCRL-VDLKTGAS 213
Query: 471 VDKQVYR----NLTTVTQLI*TQ 527
+DK V+R +LT+V Q + T+
Sbjct: 214 LDKDVFRKDLGDLTSVYQEVLTR 236
>UniRef50_Q98NM8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
1; n=116; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
1 - Rhizobium loti (Mesorhizobium loti)
Length = 264
Score = 48.8 bits (111), Expect = 1e-04
Identities = 31/78 (39%), Positives = 41/78 (52%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L GI T F++ + L K+ E+IP+E V R +A GS KR G+ EG E
Sbjct: 61 LNRMGIPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLSKRL-GIEEGTVLPRSIIE 119
Query: 181 TFFKDDANHDPQWSEEQI 234
++K DA DP SEE I
Sbjct: 120 FYYKADALDDPMVSEEHI 137
>UniRef50_Q6LZT3 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=5; Methanococcus|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanococcus maripaludis
Length = 246
Score = 48.0 bits (109), Expect = 2e-04
Identities = 25/76 (32%), Positives = 43/76 (56%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
L +E+ ++K + + ++L+ + + L+D KIE G +G IV+AD I D+ RL
Sbjct: 151 LATEEELVEIKKLALKVNDVLKGFFDEKGIMLVDFKIEVGKTADGQIVVADEISPDTMRL 210
Query: 444 WPSGDKRLMVDKQVYR 491
W K ++ DK V+R
Sbjct: 211 WDKETKDVL-DKDVFR 225
>UniRef50_Q9X0X0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Thermotogaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Thermotoga maritima
Length = 230
Score = 47.6 bits (108), Expect = 3e-04
Identities = 25/73 (34%), Positives = 44/73 (60%)
Frame = +3
Query: 273 RDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPS 452
+ + + M++A + I L++ + + L D+K EFG+D +G++VL D I D++RL
Sbjct: 138 KKQAEKMKEAAVKITLALKEFFERANFELWDIKYEFGLDKDGNVVLGDEISPDTFRLRKK 197
Query: 453 GDKRLMVDKQVYR 491
G+ + DK VYR
Sbjct: 198 GE---IFDKDVYR 207
Score = 44.4 bits (100), Expect = 0.003
Identities = 27/71 (38%), Positives = 32/71 (45%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L GIKT V+ +M P+E V R GSF++R G EG P E
Sbjct: 54 LSEKGIKTHLVEYIPPRTLKVIPLKMFPLEVVVRLKKAGSFVRRYGGA-EGEDLPVPLVE 112
Query: 181 TFFKDDANHDP 213
F KDD HDP
Sbjct: 113 FFIKDDERHDP 123
>UniRef50_Q8ZZK5 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Pyrobaculum|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pyrobaculum aerophilum
Length = 234
Score = 47.6 bits (108), Expect = 3e-04
Identities = 26/76 (34%), Positives = 40/76 (52%)
Frame = +1
Query: 16 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 195
++T FV+ A E+IP+E + R A GS L+R P + E + P E +KD
Sbjct: 60 VETHFVEYKPPNALAVIPAEVIPVEVIVRFKAYGSQLRRMPRLRELQHLSRPLVEFHYKD 119
Query: 196 DANHDPQWSEEQIISA 243
DA HDP ++++ A
Sbjct: 120 DALHDPLVYPQEVVEA 135
Score = 39.5 bits (88), Expect = 0.083
Identities = 25/85 (29%), Positives = 40/85 (47%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
L EV+ + + + L +A C ID+K EFG G ++L D + D++RL
Sbjct: 137 LAAPQEVEAIEEMAVRAASALRDLYARAGCDFIDVKFEFG-RRGGRLILVDEVSGDTFRL 195
Query: 444 WPSGDKRLMVDKQVYRNLTTVTQLI 518
G+ +DK+ +R V LI
Sbjct: 196 LCRGEH---LDKEYFRKTKDVNGLI 217
>UniRef50_Q9RXT0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=37; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Deinococcus radiodurans
Length = 237
Score = 47.2 bits (107), Expect = 4e-04
Identities = 28/71 (39%), Positives = 39/71 (54%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L++AGI T F++ S+ K ++P+E + R +A GSF KR GV EG P E
Sbjct: 61 LEAAGIPTHFLEKLSDREQRVKAVTIVPVEVIVRNVAAGSFSKR-LGVEEGTPLPRPVVE 119
Query: 181 TFFKDDANHDP 213
+K DA DP
Sbjct: 120 YCYKSDALGDP 130
Score = 44.4 bits (100), Expect = 0.003
Identities = 26/72 (36%), Positives = 37/72 (51%)
Frame = +3
Query: 276 DEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSG 455
D++ +R+ + I + L + R LID K+EFG G IVLAD I D+ R W +
Sbjct: 146 DDLKRIRELALQIRDFLVPYFEKRGVRLIDFKLEFGKLPSGEIVLADEISPDTCRFWDAE 205
Query: 456 DKRLMVDKQVYR 491
M DK +R
Sbjct: 206 TNEKM-DKDRFR 216
>UniRef50_A4SAQ9 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Ostreococcus lucimarinus CCE9901|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Ostreococcus lucimarinus CCE9901
Length = 367
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/86 (32%), Positives = 45/86 (52%), Gaps = 5/86 (5%)
Frame = +3
Query: 210 SPMVRGANHFSQIQLNGLL----IGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIE 377
+P + H I L ++ + +D++DY T+ +F ++ A R L+D K E
Sbjct: 197 TPTTKEKEHDRPISLEDIVKEGWMKQDDLDYCVAKTLEVFAYAQEVAATRGLILVDTKYE 256
Query: 378 FGVDTEGSIVLADVIDS-DSWRLWPS 452
FG D +G+I L D I++ DS R W S
Sbjct: 257 FGRDADGTIRLIDEINTPDSSRYWLS 282
>UniRef50_O28997 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit; n=1; Archaeoglobus fulgidus|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit - Archaeoglobus fulgidus
Length = 180
Score = 46.0 bits (104), Expect = 0.001
Identities = 19/48 (39%), Positives = 31/48 (64%)
Frame = +2
Query: 590 KVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIMQ 733
K V+ MGS +D ++ +KIA + G+D +R+ SAHK E+ L I++
Sbjct: 28 KAVIIMGSKSDLDYSKKIASKLADFGIDAVMRIASAHKTPEKVLEIIK 75
>UniRef50_Q5JD27 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Thermococcus kodakarensis KOD1|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Pyrococcus kodakaraensis (Thermococcus kodakaraensis)
Length = 219
Score = 44.0 bits (99), Expect = 0.004
Identities = 28/79 (35%), Positives = 42/79 (53%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 180
L+ GI+T FV+ E + E IP+E + R LA GSFL+R G + + +
Sbjct: 63 LEEKGIRTHFVERIDERRARFLRAERIPLEVIYRELAYGSFLRRYQGWVKELKPLGIVEF 122
Query: 181 TFFKDDANHDPQWSEEQII 237
T KDD+ DP +EE ++
Sbjct: 123 T-LKDDSLKDPLITEEAVV 140
Score = 35.5 bits (78), Expect = 1.4
Identities = 18/59 (30%), Positives = 33/59 (55%)
Frame = +3
Query: 279 EVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSG 455
EV M++ T + EIL + ++ + L+D K+EFG G +++ D + D+ R+ G
Sbjct: 149 EVREMKEKTRKVAEILREFFSSKGLQLVDFKLEFG-RRNGELIVIDELSGDTMRVIKDG 206
>UniRef50_Q73PW0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Treponema denticola|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Treponema denticola
Length = 316
Score = 43.6 bits (98), Expect = 0.005
Identities = 21/61 (34%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Frame = +3
Query: 267 IGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDS-DSWRL 443
+ +++ D+++KA + +FE +K+ L+D K EFGVD +I+L D + + DS R
Sbjct: 170 LSKEQWDFVQKAALALFERGQKSAKEAGLILVDTKYEFGVDKNNNILLIDEVHTPDSSRY 229
Query: 444 W 446
W
Sbjct: 230 W 230
>UniRef50_Q73PV9 Cluster: Phosphoribosylaminoimidazole carboxylase,
PurE protein; n=1; Treponema denticola|Rep:
Phosphoribosylaminoimidazole carboxylase, PurE protein -
Treponema denticola
Length = 159
Score = 42.7 bits (96), Expect = 0.009
Identities = 16/47 (34%), Positives = 29/47 (61%)
Frame = +2
Query: 593 VVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIMQ 733
V++ MGS +D H +KIA + G++ +R+ SAHK E + +++
Sbjct: 5 VIILMGSSSDMGHAEKIASELKTFGIEYAIRIGSAHKTAEHVVSMLK 51
>UniRef50_Q8TIS9 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=8; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanosarcina acetivorans
Length = 237
Score = 41.9 bits (94), Expect = 0.016
Identities = 26/73 (35%), Positives = 39/73 (53%)
Frame = +3
Query: 273 RDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPS 452
R+E+ +RK + I E+L + L D K+EFG +G I+L+D I D+ R W
Sbjct: 144 REELATLRKLALRINELLVPYLDEKGILLPDFKLEFG-RRDGEIILSDEISCDTCRFWDK 202
Query: 453 GDKRLMVDKQVYR 491
+ M DK V+R
Sbjct: 203 KTGQSM-DKDVFR 214
>UniRef50_A7CZ13 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Opitutaceae bacterium TAV2|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Opitutaceae bacterium TAV2
Length = 306
Score = 41.5 bits (93), Expect = 0.021
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 1/65 (1%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWR 440
++G + ++ A++ ++ + A L D K EFG D G++VL D ++ DS R
Sbjct: 187 IVGPALYEQVKAASLALYSLGHDKAARAGMILADTKFEFGTDAAGNLVLIDEILTPDSSR 246
Query: 441 LWPSG 455
WP+G
Sbjct: 247 YWPAG 251
>UniRef50_A0RW02 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR)
synthase; n=1; Cenarchaeum symbiosum|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR)
synthase - Cenarchaeum symbiosum
Length = 273
Score = 41.5 bits (93), Expect = 0.021
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
L+ E D++ +I ++ + A L D+K+EFG GSI L D I D RL
Sbjct: 143 LVTEKEYDWLSAKSIEVYNAMSVAAEAAGFVLADVKLEFG-RLGGSITLGDSIGPDECRL 201
Query: 444 WPS-----GDKRLMVDKQVYRN 494
WP+ G + DKQ+ R+
Sbjct: 202 WPAEQYSPGAIQEAFDKQILRD 223
>UniRef50_Q3WE59 Cluster: SAICAR synthetase; n=5; Bacteria|Rep:
SAICAR synthetase - Frankia sp. EAN1pec
Length = 354
Score = 40.7 bits (91), Expect = 0.036
Identities = 29/87 (33%), Positives = 40/87 (45%), Gaps = 6/87 (6%)
Frame = +3
Query: 267 IGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWRL 443
+G + + + T+ IF A R L D K EFG D +G + LAD V+ DS R
Sbjct: 226 VGAELAAELERLTLQIFGRASDLAAERGILLADTKFEFGHDADGVLRLADEVLTPDSSRF 285
Query: 444 WPS-----GDKRLMVDKQVYRNLTTVT 509
WP+ G + DKQ R+ T
Sbjct: 286 WPADAWTPGGTQPSYDKQFIRDYLVST 312
>UniRef50_Q7UJ19 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=2; Planctomycetaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Rhodopirellula baltica
Length = 320
Score = 39.1 bits (87), Expect = 0.11
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 6/81 (7%)
Frame = +3
Query: 267 IGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWRL 443
+G ++ +R+ ++ I++ K A R + D K EFGV +G ++L D V+ DS R
Sbjct: 199 LGEEQSSQLRRMSLAIYQDASKIAAERGLLIADTKFEFGV-VDGELMLIDEVLTPDSSRF 257
Query: 444 WPS-----GDKRLMVDKQVYR 491
W + G + DKQ R
Sbjct: 258 WAADEYEPGHSQRSFDKQFVR 278
>UniRef50_P38025 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase, chloroplast precursor; n=13; cellular
organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase, chloroplast precursor - Arabidopsis thaliana
(Mouse-ear cress)
Length = 411
Score = 39.1 bits (87), Expect = 0.11
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 5/87 (5%)
Frame = +3
Query: 210 SPMVRGANHFSQIQLNGLLIG----RDEVDYMRKATILIFEILEKAWALRDCALIDMKIE 377
+P + A+H I N ++ G + E D + +FE + L+D K E
Sbjct: 235 TPTTKAADHDVPISPNEIVEGGFMTQAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYE 294
Query: 378 FGVDTEGSIVLADVIDS-DSWRLWPSG 455
FG ++GSI+L D I + DS R W +G
Sbjct: 295 FGRSSDGSILLIDEIHTPDSSRYWLAG 321
>UniRef50_Q1MRH1 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase; n=7; Proteobacteria|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase - Lawsonia intracellularis (strain PHE/MN1-00)
Length = 298
Score = 38.7 bits (86), Expect = 0.15
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWAL-RDCALIDMKIEFGVDTEGSIVLAD-VIDSDSW 437
L+G+D + ++L+F WA R + D K EFG+ +G ++L D V+ DS
Sbjct: 175 LLGKDTTTLVASLSLLMFNEAS-VWAEDRGIIIADTKFEFGI-LDGQVILIDEVLTPDSS 232
Query: 438 RLWPS-----GDKRLMVDKQVYRN 494
R WP+ G + DKQ R+
Sbjct: 233 RFWPTKNYIPGKSQPSFDKQYLRD 256
>UniRef50_A1G3E0 Cluster: SAICAR synthetase; n=1; Salinispora
arenicola CNS205|Rep: SAICAR synthetase - Salinispora
arenicola CNS205
Length = 236
Score = 38.3 bits (85), Expect = 0.19
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 1/72 (1%)
Frame = +1
Query: 1 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGV-PEGFRFTPPKQ 177
L AG+ T F + +L+ +P E + + ATGS ++ PG+ EG F PP
Sbjct: 65 LAKAGVPTVFRERLGPITYLADYRPAVPFEVIVKNRATGSTTRKYPGLFEEGRVFAPPVV 124
Query: 178 ETFFKDDANHDP 213
+ ++ D P
Sbjct: 125 KFDYRTDPEDQP 136
>UniRef50_P43060 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=11; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Candida albicans (Yeast)
Length = 291
Score = 38.3 bits (85), Expect = 0.19
Identities = 18/75 (24%), Positives = 38/75 (50%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
++G++ D + K I ++ A + + D K EFG+D + +++ +V+ DS R
Sbjct: 169 IVGKELCDRIEKIAIDLYTKARDYAATKGIIIADTKFEFGLDGDKIVLVDEVLTPDSSRF 228
Query: 444 WPSGDKRLMVDKQVY 488
W + +L ++ Y
Sbjct: 229 WSAAKYKLGQSQESY 243
>UniRef50_Q648Z8 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; uncultured archaeon GZfos35D7|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- uncultured archaeon GZfos35D7
Length = 249
Score = 37.9 bits (84), Expect = 0.25
Identities = 31/86 (36%), Positives = 46/86 (53%), Gaps = 7/86 (8%)
Frame = +3
Query: 255 NGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGS--IVLADVIDS 428
NG L E+D +R+ T L EI+ + R L D KIEFG D + I+LAD + +
Sbjct: 146 NGWLTSA-ELDSIRECTRLTNEIMSERLLKRGIILADFKIEFGRDKNAAEKILLADEVGT 204
Query: 429 -DSWRLW--PSGDKRLM--VDKQVYR 491
D R W + ++ ++ +DK VYR
Sbjct: 205 PDGCRFWDRDAYEQGVIESLDKDVYR 230
>UniRef50_Q9C1J4 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=14; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pichia pastoris (Yeast)
Length = 304
Score = 37.5 bits (83), Expect = 0.33
Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 6/90 (6%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWR 440
++G+D + + + ++ + L+ + D K EFG+D +VL D V+ DS R
Sbjct: 182 IVGKDICEKVAVKAVELYSAAKNFALLKGIIIADTKFEFGLDENNELVLVDEVLTPDSSR 241
Query: 441 LWPS-----GDKRLMVDKQVYRNLTTVTQL 515
W G + DKQ R+ T L
Sbjct: 242 FWNQKTYQVGKSQESYDKQFLRDWLTANGL 271
>UniRef50_P46970 Cluster: Nonsense-mediated mRNA decay protein 5;
n=6; Saccharomycetales|Rep: Nonsense-mediated mRNA decay
protein 5 - Saccharomyces cerevisiae (Baker's yeast)
Length = 1048
Score = 37.1 bits (82), Expect = 0.44
Identities = 26/74 (35%), Positives = 40/74 (54%), Gaps = 1/74 (1%)
Frame = +3
Query: 198 RKPRSPMVRGANHFSQIQLNGLLI-GRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 374
RKP S + + F + LN +LI GR+E+ T +IFEI +KA D +L D+++
Sbjct: 724 RKPDSMVSYYLSDF-MLALNNILIYGRNELKKNEFYTKIIFEIYQKAVTAEDNSLDDLRV 782
Query: 375 EFGVDTEGSIVLAD 416
F + E + L D
Sbjct: 783 VFDLSQELVLALDD 796
>UniRef50_Q1IPE1 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=7; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Acidobacteria bacterium (strain Ellin345)
Length = 318
Score = 36.7 bits (81), Expect = 0.59
Identities = 17/60 (28%), Positives = 31/60 (51%)
Frame = +3
Query: 270 GRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWP 449
G D + +R+ +I I++ + + D K EFG+ +G ++ +V+ DS R WP
Sbjct: 198 GGDLSEKLREVSIKIYKAAADYALTKGIIIADTKFEFGMTPKGLVLADEVLTPDSSRFWP 257
>UniRef50_Q98I23 Cluster: Putative
phosphoribosylaminoimidazole-succinocarboxamide synthase
2; n=16; Alphaproteobacteria|Rep: Putative
phosphoribosylaminoimidazole-succinocarboxamide synthase
2 - Rhizobium loti (Mesorhizobium loti)
Length = 313
Score = 36.3 bits (80), Expect = 0.77
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Frame = +3
Query: 240 SQIQLNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADV 419
++I GLL + + D + + +F + A R L D K EFG D G+I+LAD
Sbjct: 159 AEILAQGLLT-QAQWDTVSDYALKLFARGQARAAERGLILADTKYEFGTDKNGTIILADE 217
Query: 420 IDS-DSWRLW 446
I + DS R W
Sbjct: 218 IHTPDSSRYW 227
>UniRef50_Q3Z881 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Dehalococcoides ethenogenes 195|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Dehalococcoides ethenogenes (strain 195)
Length = 304
Score = 35.5 bits (78), Expect = 1.4
Identities = 19/82 (23%), Positives = 41/82 (50%), Gaps = 5/82 (6%)
Frame = +3
Query: 264 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 443
++G++ D + + ++ ++++ + R + D K EFG+D I++ + + DS R
Sbjct: 182 MVGKELADKLAEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSRF 241
Query: 444 WPS-----GDKRLMVDKQVYRN 494
W G+ + DKQ R+
Sbjct: 242 WDEKTYRVGEAQDSYDKQPVRD 263
>UniRef50_Q1MPV1 Cluster: Phosphoribosylcarboxyaminoimidazole
(NCAIR) mutase; n=1; Lawsonia intracellularis
PHE/MN1-00|Rep: Phosphoribosylcarboxyaminoimidazole
(NCAIR) mutase - Lawsonia intracellularis (strain
PHE/MN1-00)
Length = 171
Score = 35.5 bits (78), Expect = 1.4
Identities = 15/49 (30%), Positives = 26/49 (53%)
Frame = +2
Query: 584 HHKVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIM 730
H KV +F+GSP+D+ + +L + V+SAH+ E T ++
Sbjct: 3 HVKVAIFIGSPSDESIVSPCTEILTQLNIPYIFTVSSAHRTPERTAELI 51
>UniRef50_Q8F0I0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Leptospira|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Leptospira interrogans
Length = 285
Score = 35.5 bits (78), Expect = 1.4
Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 10/91 (10%)
Frame = +3
Query: 267 IGRDEVDYMRKATILIF----EILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSD 431
IG++ + +++ +I IF E+++KA + L D K EFG+ +G ++L D ++ D
Sbjct: 161 IGKELFNILKEKSISIFLRASEVVDKAGII----LCDTKFEFGI-LDGQVILIDELLTPD 215
Query: 432 SWRLWPS-----GDKRLMVDKQVYRNLTTVT 509
S R W + G +DKQ+ RN T
Sbjct: 216 SSRYWSTDTYSVGISPPSLDKQILRNYLETT 246
>UniRef50_Q8AAD6 Cluster: Indole-3-glycerol phosphate synthase; n=7;
Bacteroidales|Rep: Indole-3-glycerol phosphate synthase
- Bacteroides thetaiotaomicron
Length = 260
Score = 35.1 bits (77), Expect = 1.8
Identities = 19/63 (30%), Positives = 36/63 (57%)
Frame = +2
Query: 515 DLDTVKRNFAWVKDQLDFLKPTIHHKVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTS 694
D+ ++++F + QL + + V+ + + QE CQ++A+ A ELGL+V L + S
Sbjct: 111 DVPIIRKDFIIDEYQL-YQAKIVGADAVLLIAAALKQEKCQELAEQAHELGLEVLLEIHS 169
Query: 695 AHK 703
A +
Sbjct: 170 AEE 172
>UniRef50_Q2NEA3 Cluster: PurE; n=3; Archaea|Rep: PurE -
Methanosphaera stadtmanae (strain DSM 3091)
Length = 354
Score = 34.7 bits (76), Expect = 2.4
Identities = 16/47 (34%), Positives = 26/47 (55%)
Frame = +2
Query: 590 KVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIM 730
KV++ +GS +D + +K K ++ + DLRV SAH+ IM
Sbjct: 19 KVMIILGSGSDYKIAEKTVKVFEQMKVPYDLRVASAHRTHNRIKDIM 65
>UniRef50_Q4UML8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=8; Rickettsia|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Rickettsia felis (Rickettsia azadi)
Length = 236
Score = 34.7 bits (76), Expect = 2.4
Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 3/68 (4%)
Frame = +3
Query: 252 LNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFG---VDTEGSIVLADVI 422
LN + RDE+ +++ + I++ L + L++ K+EFG E I+L D I
Sbjct: 135 LNFGWLTRDEIKAVKEQALRIYDFLSGLFIGVGIRLVECKLEFGRVFNGEESIIMLTDEI 194
Query: 423 DSDSWRLW 446
D+ RLW
Sbjct: 195 SPDNCRLW 202
>UniRef50_Q0AXN6 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Syntrophomonas wolfei subsp. wolfei (strain
Goettingen)
Length = 225
Score = 34.3 bits (75), Expect = 3.1
Identities = 26/75 (34%), Positives = 42/75 (56%)
Frame = +3
Query: 231 NHFSQIQLNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVL 410
N S IQL GLL R E++ ++ + I++ AL+ L+D+K EFG + IV+
Sbjct: 140 NDESLIQL-GLLTER-ELEIIKALARKVAVIVKNDLALKGLELVDIKFEFGRIGQ-EIVV 196
Query: 411 ADVIDSDSWRLWPSG 455
D I D+ R++ +G
Sbjct: 197 IDDISGDNMRVFKNG 211
>UniRef50_A0Q508 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=14; Gammaproteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Francisella tularensis subsp. novicida (strain U112)
Length = 770
Score = 34.3 bits (75), Expect = 3.1
Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Frame = +3
Query: 285 DYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTE-GSIVLADVIDS-DSWRLW 446
D+ + + +FE +K L D K EFG+D + G I+L D I + DS R W
Sbjct: 180 DFASQKALELFEFGQKKALEHGLILADTKYEFGIDEQTGEIILIDEIHTPDSSRFW 235
>UniRef50_P41654 Cluster: Probable phosphoribosylaminoimidazole
carboxylase; n=2; Methanothermobacter thermautotrophicus
str. Delta H|Rep: Probable phosphoribosylaminoimidazole
carboxylase - Methanobacterium thermoautotrophicum
Length = 334
Score = 34.3 bits (75), Expect = 3.1
Identities = 16/47 (34%), Positives = 27/47 (57%)
Frame = +2
Query: 590 KVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIM 730
+V++ +GS +D +K + EL + DLRV SAH+ E+ I+
Sbjct: 4 RVMILLGSASDFRIAEKAMEIFEELRIPYDLRVASAHRTHEKVKAIV 50
>UniRef50_Q9YBE5 Cluster: PqqE homolog; n=4; Thermoprotei|Rep: PqqE
homolog - Aeropyrum pernix
Length = 389
Score = 32.7 bits (71), Expect = 9.5
Identities = 21/65 (32%), Positives = 34/65 (52%)
Frame = +2
Query: 539 FAWVKDQLDFLKPTIHHKVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEET 718
F++V LD + P +H K F G+P + + A+ A E GLDV R+T ++
Sbjct: 135 FSYVGISLDSVDPGVHDK---FRGAPGAFKAAIRGARNALEEGLDVGFRLTITKYNLDDA 191
Query: 719 LRIMQ 733
RI++
Sbjct: 192 PRIIR 196
>UniRef50_A7DSW8 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Candidatus Nitrosopumilus maritimus SCM1
Length = 274
Score = 32.7 bits (71), Expect = 9.5
Identities = 21/50 (42%), Positives = 25/50 (50%), Gaps = 4/50 (8%)
Frame = +1
Query: 28 FVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKR----NPGVPEGFRFT 165
F+K SE L KK +M+PIE V R GS + R VPEG T
Sbjct: 63 FIKRESENEILVKKMKMLPIECVVRGYFYGSLVSRWKKGEVQVPEGTNTT 112
>UniRef50_Q895U7 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=8; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Clostridium tetani
Length = 227
Score = 32.7 bits (71), Expect = 9.5
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +3
Query: 246 IQLNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFG-VDTEGSIVLADVI 422
+ + G+L R E D ++ T I I++ + + L D+K+EFG +D + I L D I
Sbjct: 144 LDMLGILSLR-EYDILKDLTKKISGIVKDELSKKGIELYDIKLEFGRIDEDNHIALIDEI 202
Query: 423 DSDSWRLWPSGD 458
+ R + G+
Sbjct: 203 SGGNMRAYKDGE 214
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 761,052,863
Number of Sequences: 1657284
Number of extensions: 16054453
Number of successful extensions: 38339
Number of sequences better than 10.0: 66
Number of HSP's better than 10.0 without gapping: 37092
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 38315
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 59265488880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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