Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NV060568.seq
(622 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase (oxa... 69 1e-11
BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3, NADP(+)... 67 4e-11
X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase (oxa... 60 6e-09
U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-depende... 60 6e-09
L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzy... 60 6e-09
BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 60 6e-09
AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 60 6e-09
AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1, NADP(+)... 60 6e-09
AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 60 6e-09
AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme ... 60 6e-09
AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial NADP(+)-d... 58 3e-08
AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens ... 58 3e-08
M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+ -de... 53 7e-07
BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein. 53 7e-07
AB045122-1|BAB40980.1| 44|Homo sapiens ME2 protein. 35 0.20
>X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase
(oxaloacetate decarboxylating) (NADP+) protein.
Length = 604
Score = 69.3 bits (162), Expect = 1e-11
Identities = 35/67 (52%), Positives = 45/67 (67%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG D R+P LNKG+AFTLEER LGIHGL+ F SQ+ QL +R + +L+KY+
Sbjct: 49 RGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYI 108
Query: 488 YLVELQD 508
L+ LQD
Sbjct: 109 ILMTLQD 115
Score = 57.6 bits (133), Expect = 3e-08
Identities = 23/36 (63%), Positives = 30/36 (83%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L +VEK++PIVY P VGLACQ +GL +R
Sbjct: 118 EKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFR 153
>BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3,
NADP(+)-dependent, mitochondrial protein.
Length = 604
Score = 67.3 bits (157), Expect = 4e-11
Identities = 34/67 (50%), Positives = 44/67 (65%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG D R+P LNKG+AFTLEER LGIHGL+ F Q+ QL +R + +L+KY+
Sbjct: 49 RGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYI 108
Query: 488 YLVELQD 508
L+ LQD
Sbjct: 109 ILMTLQD 115
Score = 57.6 bits (133), Expect = 3e-08
Identities = 23/36 (63%), Positives = 30/36 (83%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L +VEK++PIVY P VGLACQ +GL +R
Sbjct: 118 EKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFR 153
>X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase
(oxaloacetate decarboxylating) (NADP+) protein.
Length = 572
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 14 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 73
Query: 488 YLVELQD 508
L++LQD
Sbjct: 74 LLMDLQD 80
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 83 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 118
>U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-dependent
malic enzyme protein.
Length = 565
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 7 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 66
Query: 488 YLVELQD 508
L++LQD
Sbjct: 67 LLMDLQD 73
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 76 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 111
>L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzyme
protein.
Length = 572
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 14 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 73
Query: 488 YLVELQD 508
L++LQD
Sbjct: 74 LLMDLQD 80
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 83 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 118
>BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 14 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 73
Query: 488 YLVELQD 508
L++LQD
Sbjct: 74 LLMDLQD 80
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 83 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 118
>AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 14 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 73
Query: 488 YLVELQD 508
L++LQD
Sbjct: 74 LLMDLQD 80
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 83 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 118
>AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 14 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 73
Query: 488 YLVELQD 508
L++LQD
Sbjct: 74 LLMDLQD 80
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 83 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 118
>AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 14 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 73
Query: 488 YLVELQD 508
L++LQD
Sbjct: 74 LLMDLQD 80
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 83 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 118
>AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme 1
variant protein.
Length = 572
Score = 60.1 bits (139), Expect = 6e-09
Identities = 32/67 (47%), Positives = 41/67 (61%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
RG R+P LNK LAFTLEER L IHGLL F SQE Q+ + + + ++YL
Sbjct: 14 RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYL 73
Query: 488 YLVELQD 508
L++LQD
Sbjct: 74 LLMDLQD 80
Score = 56.8 bits (131), Expect = 6e-08
Identities = 21/36 (58%), Positives = 31/36 (86%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L ++EK++PIVY P VGLACQ++ L++R
Sbjct: 83 EKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFR 118
>AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial
NADP(+)-dependent malic enzyme 3 protein.
Length = 259
Score = 57.6 bits (133), Expect = 3e-08
Identities = 23/36 (63%), Positives = 30/36 (83%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L +VEK++PIVY P VGLACQ +GL +R
Sbjct: 56 EKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFR 91
Score = 50.8 bits (116), Expect = 4e-06
Identities = 26/53 (49%), Positives = 35/53 (66%)
Frame = +2
Query: 350 LAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYLYLVELQD 508
+AFTLEER LGIHGL+ F SQ+ QL +R + +L+KY+ L+ LQD
Sbjct: 1 MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQD 53
>AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens
cDNA FLJ34862 fis, clone NT2NE2013547, highly similar to
NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL PRECURSOR (EC
1.1.1.40). ).
Length = 252
Score = 57.6 bits (133), Expect = 3e-08
Identities = 23/36 (63%), Positives = 30/36 (83%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L +VEK++PIVY P VGLACQ +GL +R
Sbjct: 56 EKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFR 91
Score = 50.8 bits (116), Expect = 4e-06
Identities = 26/53 (49%), Positives = 35/53 (66%)
Frame = +2
Query: 350 LAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYLYLVELQD 508
+AFTLEER LGIHGL+ F SQ+ QL +R + +L+KY+ L+ LQD
Sbjct: 1 MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQD 53
>M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+
-dependent malic enzyme protein.
Length = 584
Score = 53.2 bits (122), Expect = 7e-07
Identities = 25/67 (37%), Positives = 42/67 (62%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
+G + +PR NKG+AFTL+ER LG+ GLL K ++Q+ Q ++ + L KY+
Sbjct: 24 KGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYI 83
Query: 488 YLVELQD 508
Y++ +Q+
Sbjct: 84 YIMGIQE 90
Score = 52.0 bits (119), Expect = 2e-06
Identities = 20/36 (55%), Positives = 29/36 (80%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L +++E +PIVY P VGLAC ++G I+R
Sbjct: 93 EKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFR 128
>BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein.
Length = 479
Score = 53.2 bits (122), Expect = 7e-07
Identities = 25/67 (37%), Positives = 42/67 (62%)
Frame = +2
Query: 308 RGIDHLRDPRLNKGLAFTLEERXALGIHGLLAAKFKSQEEQLDICRISVDRYEDNLNKYL 487
+G + +PR NKG+AFTL+ER LG+ GLL K ++Q+ Q ++ + L KY+
Sbjct: 24 KGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYI 83
Query: 488 YLVELQD 508
Y++ +Q+
Sbjct: 84 YIMGIQE 90
Score = 52.0 bits (119), Expect = 2e-06
Identities = 20/36 (55%), Positives = 29/36 (80%)
Frame = +1
Query: 514 EKLFFRLLAENVEKYLPIVYXPNVGLACQRFGLIYR 621
EKLF+R+L +++E +PIVY P VGLAC ++G I+R
Sbjct: 93 EKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFR 128
>AB045122-1|BAB40980.1| 44|Homo sapiens ME2 protein.
Length = 44
Score = 35.1 bits (77), Expect = 0.20
Identities = 15/28 (53%), Positives = 21/28 (75%)
Frame = +2
Query: 347 GLAFTLEERXALGIHGLLAAKFKSQEEQ 430
G+AFTL+ER LG+ GLL K ++Q+ Q
Sbjct: 1 GMAFTLQERQMLGLQGLLPPKIETQDIQ 28
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 81,700,224
Number of Sequences: 237096
Number of extensions: 1559552
Number of successful extensions: 2913
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 2816
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2912
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 6691573490
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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