Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NV021816X
(536 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase (oxa... 133 4e-31
BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3, NADP(+)... 133 4e-31
AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial NADP(+)-d... 133 4e-31
AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens ... 133 4e-31
M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+ -de... 131 2e-30
BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein. 131 2e-30
X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase (oxa... 130 4e-30
U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-depende... 130 4e-30
L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzy... 130 4e-30
BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 130 4e-30
AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 130 4e-30
AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1, NADP(+)... 130 4e-30
AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 130 4e-30
AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme ... 130 4e-30
AB045122-1|BAB40980.1| 44|Homo sapiens ME2 protein. 49 1e-05
>X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase
(oxaloacetate decarboxylating) (NADP+) protein.
Length = 604
Score = 133 bits (321), Expect = 4e-31
Identities = 58/86 (67%), Positives = 71/86 (82%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+YI LM L DRNE LFYR + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDK
Sbjct: 106 KYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDK 165
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ +L +WPE +++A+VVTDGERI
Sbjct: 166 GHLATMLNSWPEDNIKAVVVTDGERI 191
Score = 55.6 bits (128), Expect = 1e-07
Identities = 28/61 (45%), Positives = 39/61 (63%)
Frame = +1
Query: 85 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNNTSI 264
G D ++P LNKGMAFT+EER LGIHGL+PP +Q+ Q+ +R ++ L+ I
Sbjct: 50 GYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYII 109
Query: 265 L 267
L
Sbjct: 110 L 110
>BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3,
NADP(+)-dependent, mitochondrial protein.
Length = 604
Score = 133 bits (321), Expect = 4e-31
Identities = 58/86 (67%), Positives = 71/86 (82%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+YI LM L DRNE LFYR + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDK
Sbjct: 106 KYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDK 165
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ +L +WPE +++A+VVTDGERI
Sbjct: 166 GHLATMLNSWPEDNIKAVVVTDGERI 191
Score = 53.6 bits (123), Expect = 4e-07
Identities = 28/61 (45%), Positives = 38/61 (62%)
Frame = +1
Query: 85 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNNTSI 264
G D ++P LNKGMAFT+EER LGIHGL+PP Q+ Q+ +R ++ L+ I
Sbjct: 50 GYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYII 109
Query: 265 L 267
L
Sbjct: 110 L 110
>AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial
NADP(+)-dependent malic enzyme 3 protein.
Length = 259
Score = 133 bits (321), Expect = 4e-31
Identities = 58/86 (67%), Positives = 71/86 (82%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+YI LM L DRNE LFYR + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDK
Sbjct: 44 KYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDK 103
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ +L +WPE +++A+VVTDGERI
Sbjct: 104 GHLATMLNSWPEDNIKAVVVTDGERI 129
Score = 41.1 bits (92), Expect = 0.002
Identities = 21/48 (43%), Positives = 30/48 (62%)
Frame = +1
Query: 124 MAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNNTSIL 267
MAFT+EER LGIHGL+PP +Q+ Q+ +R ++ L+ IL
Sbjct: 1 MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIIL 48
>AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens
cDNA FLJ34862 fis, clone NT2NE2013547, highly similar to
NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL PRECURSOR (EC
1.1.1.40). ).
Length = 252
Score = 133 bits (321), Expect = 4e-31
Identities = 58/86 (67%), Positives = 71/86 (82%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+YI LM L DRNE LFYR + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDK
Sbjct: 44 KYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDK 103
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ +L +WPE +++A+VVTDGERI
Sbjct: 104 GHLATMLNSWPEDNIKAVVVTDGERI 129
Score = 41.1 bits (92), Expect = 0.002
Identities = 21/48 (43%), Positives = 30/48 (62%)
Frame = +1
Query: 124 MAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNNTSIL 267
MAFT+EER LGIHGL+PP +Q+ Q+ +R ++ L+ IL
Sbjct: 1 MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIIL 48
>M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+
-dependent malic enzyme protein.
Length = 584
Score = 131 bits (316), Expect = 2e-30
Identities = 53/86 (61%), Positives = 72/86 (83%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+YIY+MG+ +RNE LFYR + D++ +MPIVYTPTVGLAC ++G ++RRP+GLFI+I D+
Sbjct: 81 KYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDR 140
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GHV ++ NWPE V+A+VVTDGERI
Sbjct: 141 GHVRSIVDNWPENHVKAVVVTDGERI 166
Score = 56.0 bits (129), Expect = 8e-08
Identities = 24/57 (42%), Positives = 38/57 (66%)
Frame = +1
Query: 103 HPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNNTSILWG 273
+P NKGMAFT++ERQ+LG+ GLLPP+++TQ+ Q ++ + +PL + G
Sbjct: 31 NPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMG 87
>BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein.
Length = 479
Score = 131 bits (316), Expect = 2e-30
Identities = 53/86 (61%), Positives = 72/86 (83%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+YIY+MG+ +RNE LFYR + D++ +MPIVYTPTVGLAC ++G ++RRP+GLFI+I D+
Sbjct: 81 KYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDR 140
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GHV ++ NWPE V+A+VVTDGERI
Sbjct: 141 GHVRSIVDNWPENHVKAVVVTDGERI 166
Score = 56.0 bits (129), Expect = 8e-08
Identities = 24/57 (42%), Positives = 38/57 (66%)
Frame = +1
Query: 103 HPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNNTSILWG 273
+P NKGMAFT++ERQ+LG+ GLLPP+++TQ+ Q ++ + +PL + G
Sbjct: 31 NPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMG 87
>X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase
(oxaloacetate decarboxylating) (NADP+) protein.
Length = 572
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 71 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 130
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 131 GHIASVLNAWPEDVIKAIVVTDGERI 156
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 55
>U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-dependent
malic enzyme protein.
Length = 565
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 64 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 123
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 124 GHIASVLNAWPEDVIKAIVVTDGERI 149
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 13 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 48
>L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzyme
protein.
Length = 572
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 71 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 130
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 131 GHIASVLNAWPEDVIKAIVVTDGERI 156
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 55
>BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 71 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 130
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 131 GHIASVLNAWPEDVIKAIVVTDGERI 156
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 55
>AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 71 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 130
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 131 GHIASVLNAWPEDVIKAIVVTDGERI 156
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 55
>AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 71 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 130
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 131 GHIASVLNAWPEDVIKAIVVTDGERI 156
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 55
>AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 71 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 130
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 131 GHIASVLNAWPEDVIKAIVVTDGERI 156
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 55
>AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme 1
variant protein.
Length = 572
Score = 130 bits (313), Expect = 4e-30
Identities = 56/86 (65%), Positives = 70/86 (81%)
Frame = +3
Query: 252 QYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 431
+Y+ LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+
Sbjct: 71 RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDR 130
Query: 432 GHVYDVLKNWPETDVRAIVVTDGERI 509
GH+ VL WPE ++AIVVTDGERI
Sbjct: 131 GHIASVLNAWPEDVIKAIVVTDGERI 156
Score = 51.6 bits (118), Expect = 2e-06
Identities = 23/36 (63%), Positives = 28/36 (77%)
Frame = +1
Query: 100 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV 207
++P LNK +AFT+EERQ L IHGLLPP +QE QV
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV 55
>AB045122-1|BAB40980.1| 44|Homo sapiens ME2 protein.
Length = 44
Score = 48.8 bits (111), Expect = 1e-05
Identities = 20/43 (46%), Positives = 32/43 (74%)
Frame = +1
Query: 121 GMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPL 249
GMAFT++ERQ+LG+ GLLPP+++TQ+ Q ++ + +PL
Sbjct: 1 GMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPL 43
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 93,307,634
Number of Sequences: 237096
Number of extensions: 2265933
Number of successful extensions: 6461
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 6097
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6461
length of database: 76,859,062
effective HSP length: 85
effective length of database: 56,705,902
effective search space used: 5273648886
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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