Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NV021238
(743 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
M36067-1|AAA59518.1| 919|Homo sapiens LIG1 protein. 121 2e-27
BC110622-1|AAI10623.1| 801|Homo sapiens LIG1 protein protein. 121 2e-27
BC108318-1|AAI08319.1| 919|Homo sapiens ligase I, DNA, ATP-depe... 121 2e-27
AF527418-1|AAM77697.1| 919|Homo sapiens ligase I, DNA, ATP-depe... 121 2e-27
AB208791-1|BAD92028.1| 832|Homo sapiens DNA ligase I variant pr... 121 2e-27
X84740-1|CAA59230.1| 922|Homo sapiens DNA ligase III protein. 60 8e-09
U40671-1|AAA85022.1| 862|Homo sapiens DNA ligase III protein. 60 8e-09
BC068005-1|AAH68005.1| 1009|Homo sapiens ligase III, DNA, ATP-de... 60 8e-09
AF491645-1|AAL91592.1| 862|Homo sapiens ligase III, DNA, ATP-de... 60 8e-09
X83441-1|CAA58467.1| 844|Homo sapiens DNA ligase IV protein. 59 2e-08
BC037491-1|AAH37491.1| 911|Homo sapiens ligase IV, DNA, ATP-dep... 59 2e-08
AL157762-1|CAH70629.1| 911|Homo sapiens ligase IV, DNA, ATP-dep... 59 2e-08
AF479264-1|AAL77435.1| 844|Homo sapiens ligase IV, DNA, ATP-dep... 59 2e-08
X52079-1|CAA36298.1| 622|Homo sapiens ITF-2 DNA binding protein... 31 5.8
M74719-1|AAA60311.1| 667|Homo sapiens SEF2-1B protein protein. 31 5.8
M74718-1|AAA60310.1| 495|Homo sapiens SEF2-1A protein protein. 31 5.8
BC125085-1|AAI25086.1| 667|Homo sapiens transcription factor 4 ... 31 5.8
BC125084-1|AAI25085.1| 671|Homo sapiens TCF4 protein protein. 31 5.8
AB209741-1|BAD92978.1| 435|Homo sapiens transcription factor 4 ... 31 5.8
>M36067-1|AAA59518.1| 919|Homo sapiens LIG1 protein.
Length = 919
Score = 121 bits (292), Expect = 2e-27
Identities = 55/76 (72%), Positives = 67/76 (88%)
Frame = -3
Query: 738 FLEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGK 559
FLE++VK+SCEGLMVK L D + Y+IA+RSHNWLKLK+DYL+GVGDT+D V+IGAY G+
Sbjct: 710 FLEQSVKDSCEGLMVKTLDVD-ATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGR 768
Query: 558 GKRAGVYGGFLVACYD 511
GKRAG YGGFL+A YD
Sbjct: 769 GKRAGRYGGFLLASYD 784
Score = 63.7 bits (148), Expect = 7e-10
Identities = 33/88 (37%), Positives = 46/88 (52%)
Frame = -2
Query: 508 ESEQFQSLCKLGTGFSDEDLQALSDMLKEHIIDSPRNYYNYDSSHSADVWTSAAVVVEVP 329
+SE+ Q++CKLGTGFSDE+L+ LK ++ SPR Y D + D W + V EV
Sbjct: 786 DSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVK 845
Query: 328 AQTCPSRSAHRAAIARLHPHKGVSLASP 245
+ AA + KG+SL P
Sbjct: 846 CADLSLSPIYPAARGLVDSDKGISLRFP 873
>BC110622-1|AAI10623.1| 801|Homo sapiens LIG1 protein protein.
Length = 801
Score = 121 bits (292), Expect = 2e-27
Identities = 55/76 (72%), Positives = 67/76 (88%)
Frame = -3
Query: 738 FLEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGK 559
FLE++VK+SCEGLMVK L D + Y+IA+RSHNWLKLK+DYL+GVGDT+D V+IGAY G+
Sbjct: 710 FLEQSVKDSCEGLMVKTLDVD-ATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGR 768
Query: 558 GKRAGVYGGFLVACYD 511
GKRAG YGGFL+A YD
Sbjct: 769 GKRAGRYGGFLLASYD 784
>BC108318-1|AAI08319.1| 919|Homo sapiens ligase I, DNA,
ATP-dependent protein.
Length = 919
Score = 121 bits (292), Expect = 2e-27
Identities = 55/76 (72%), Positives = 67/76 (88%)
Frame = -3
Query: 738 FLEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGK 559
FLE++VK+SCEGLMVK L D + Y+IA+RSHNWLKLK+DYL+GVGDT+D V+IGAY G+
Sbjct: 710 FLEQSVKDSCEGLMVKTLDVD-ATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGR 768
Query: 558 GKRAGVYGGFLVACYD 511
GKRAG YGGFL+A YD
Sbjct: 769 GKRAGRYGGFLLASYD 784
Score = 63.7 bits (148), Expect = 7e-10
Identities = 33/88 (37%), Positives = 46/88 (52%)
Frame = -2
Query: 508 ESEQFQSLCKLGTGFSDEDLQALSDMLKEHIIDSPRNYYNYDSSHSADVWTSAAVVVEVP 329
+SE+ Q++CKLGTGFSDE+L+ LK ++ SPR Y D + D W + V EV
Sbjct: 786 DSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVK 845
Query: 328 AQTCPSRSAHRAAIARLHPHKGVSLASP 245
+ AA + KG+SL P
Sbjct: 846 CADLSLSPIYPAARGLVDSDKGISLRFP 873
>AF527418-1|AAM77697.1| 919|Homo sapiens ligase I, DNA,
ATP-dependent protein.
Length = 919
Score = 121 bits (292), Expect = 2e-27
Identities = 55/76 (72%), Positives = 67/76 (88%)
Frame = -3
Query: 738 FLEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGK 559
FLE++VK+SCEGLMVK L D + Y+IA+RSHNWLKLK+DYL+GVGDT+D V+IGAY G+
Sbjct: 710 FLEQSVKDSCEGLMVKTLDVD-ATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGR 768
Query: 558 GKRAGVYGGFLVACYD 511
GKRAG YGGFL+A YD
Sbjct: 769 GKRAGRYGGFLLASYD 784
Score = 63.7 bits (148), Expect = 7e-10
Identities = 33/88 (37%), Positives = 46/88 (52%)
Frame = -2
Query: 508 ESEQFQSLCKLGTGFSDEDLQALSDMLKEHIIDSPRNYYNYDSSHSADVWTSAAVVVEVP 329
+SE+ Q++CKLGTGFSDE+L+ LK ++ SPR Y D + D W + V EV
Sbjct: 786 DSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVK 845
Query: 328 AQTCPSRSAHRAAIARLHPHKGVSLASP 245
+ AA + KG+SL P
Sbjct: 846 CADLSLSPIYPAARGLVDSDKGISLRFP 873
>AB208791-1|BAD92028.1| 832|Homo sapiens DNA ligase I variant
protein.
Length = 832
Score = 121 bits (292), Expect = 2e-27
Identities = 55/76 (72%), Positives = 67/76 (88%)
Frame = -3
Query: 738 FLEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGK 559
FLE++VK+SCEGLMVK L D + Y+IA+RSHNWLKLK+DYL+GVGDT+D V+IGAY G+
Sbjct: 741 FLEQSVKDSCEGLMVKTLDVD-ATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGR 799
Query: 558 GKRAGVYGGFLVACYD 511
GKRAG YGGFL+A YD
Sbjct: 800 GKRAGRYGGFLLASYD 815
>X84740-1|CAA59230.1| 922|Homo sapiens DNA ligase III protein.
Length = 922
Score = 60.1 bits (139), Expect = 8e-09
Identities = 31/77 (40%), Positives = 50/77 (64%), Gaps = 2/77 (2%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYL-EG-VGDTVDAVIIGAYRG 562
+ ++E EGL++K + G Y+ +R +WLK+K+DYL EG + DT D V++GA+ G
Sbjct: 559 ITRVIQEGLEGLVLKDVKGT---YEPGKR--HWLKVKKDYLNEGAMADTADLVVLGAFYG 613
Query: 561 KGKRAGVYGGFLVACYD 511
+G + G+ FL+ CYD
Sbjct: 614 QGSKGGMMSIFLMGCYD 630
>U40671-1|AAA85022.1| 862|Homo sapiens DNA ligase III protein.
Length = 862
Score = 60.1 bits (139), Expect = 8e-09
Identities = 31/77 (40%), Positives = 50/77 (64%), Gaps = 2/77 (2%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYL-EG-VGDTVDAVIIGAYRG 562
+ ++E EGL++K + G Y+ +R +WLK+K+DYL EG + DT D V++GA+ G
Sbjct: 559 ITRVIQEGLEGLVLKDVKGT---YEPGKR--HWLKVKKDYLNEGAMADTADLVVLGAFYG 613
Query: 561 KGKRAGVYGGFLVACYD 511
+G + G+ FL+ CYD
Sbjct: 614 QGSKGGMMSIFLMGCYD 630
>BC068005-1|AAH68005.1| 1009|Homo sapiens ligase III, DNA,
ATP-dependent protein.
Length = 1009
Score = 60.1 bits (139), Expect = 8e-09
Identities = 31/77 (40%), Positives = 50/77 (64%), Gaps = 2/77 (2%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYL-EG-VGDTVDAVIIGAYRG 562
+ ++E EGL++K + G Y+ +R +WLK+K+DYL EG + DT D V++GA+ G
Sbjct: 646 ITRVIQEGLEGLVLKDVKGT---YEPGKR--HWLKVKKDYLNEGAMADTADLVVLGAFYG 700
Query: 561 KGKRAGVYGGFLVACYD 511
+G + G+ FL+ CYD
Sbjct: 701 QGSKGGMMSIFLMGCYD 717
>AF491645-1|AAL91592.1| 862|Homo sapiens ligase III, DNA,
ATP-dependent protein.
Length = 862
Score = 60.1 bits (139), Expect = 8e-09
Identities = 31/77 (40%), Positives = 50/77 (64%), Gaps = 2/77 (2%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYL-EG-VGDTVDAVIIGAYRG 562
+ ++E EGL++K + G Y+ +R +WLK+K+DYL EG + DT D V++GA+ G
Sbjct: 559 ITRVIQEGLEGLVLKDVKGT---YEPGKR--HWLKVKKDYLNEGAMADTADLVVLGAFYG 613
Query: 561 KGKRAGVYGGFLVACYD 511
+G + G+ FL+ CYD
Sbjct: 614 QGSKGGMMSIFLMGCYD 630
>X83441-1|CAA58467.1| 844|Homo sapiens DNA ligase IV protein.
Length = 844
Score = 58.8 bits (136), Expect = 2e-08
Identities = 30/72 (41%), Positives = 42/72 (58%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGKG 556
L EA+ + EG+MVK S Y +R WLK+K +Y+ G+ D +D +I+G Y GKG
Sbjct: 351 LNEAIDKREEGIMVKQPL---SIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKG 407
Query: 555 KRAGVYGGFLVA 520
R G+ FL A
Sbjct: 408 SRGGMMSHFLCA 419
>BC037491-1|AAH37491.1| 911|Homo sapiens ligase IV, DNA,
ATP-dependent protein.
Length = 911
Score = 58.8 bits (136), Expect = 2e-08
Identities = 30/72 (41%), Positives = 42/72 (58%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGKG 556
L EA+ + EG+MVK S Y +R WLK+K +Y+ G+ D +D +I+G Y GKG
Sbjct: 418 LNEAIDKREEGIMVKQPL---SIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKG 474
Query: 555 KRAGVYGGFLVA 520
R G+ FL A
Sbjct: 475 SRGGMMSHFLCA 486
>AL157762-1|CAH70629.1| 911|Homo sapiens ligase IV, DNA,
ATP-dependent protein.
Length = 911
Score = 58.8 bits (136), Expect = 2e-08
Identities = 30/72 (41%), Positives = 42/72 (58%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGKG 556
L EA+ + EG+MVK S Y +R WLK+K +Y+ G+ D +D +I+G Y GKG
Sbjct: 418 LNEAIDKREEGIMVKQPL---SIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKG 474
Query: 555 KRAGVYGGFLVA 520
R G+ FL A
Sbjct: 475 SRGGMMSHFLCA 486
>AF479264-1|AAL77435.1| 844|Homo sapiens ligase IV, DNA,
ATP-dependent protein.
Length = 844
Score = 58.8 bits (136), Expect = 2e-08
Identities = 30/72 (41%), Positives = 42/72 (58%)
Frame = -3
Query: 735 LEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKQDYLEGVGDTVDAVIIGAYRGKG 556
L EA+ + EG+MVK S Y +R WLK+K +Y+ G+ D +D +I+G Y GKG
Sbjct: 351 LNEAIDKREEGIMVKQPL---SIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKG 407
Query: 555 KRAGVYGGFLVA 520
R G+ FL A
Sbjct: 408 SRGGMMSHFLCA 419
>X52079-1|CAA36298.1| 622|Homo sapiens ITF-2 DNA binding protein
protein.
Length = 622
Score = 30.7 bits (66), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Frame = -2
Query: 406 PRNYYNYDSSHSADVWTSAAVVVEVPAQTCPSRSAH---RAAIARLHPHKGVSLASPGS 239
P +++ D HS+D W+S++ + + S+H ++ LHPH+ +S S S
Sbjct: 167 PSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS 225
>M74719-1|AAA60311.1| 667|Homo sapiens SEF2-1B protein protein.
Length = 667
Score = 30.7 bits (66), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Frame = -2
Query: 406 PRNYYNYDSSHSADVWTSAAVVVEVPAQTCPSRSAH---RAAIARLHPHKGVSLASPGS 239
P +++ D HS+D W+S++ + + S+H ++ LHPH+ +S S S
Sbjct: 212 PSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS 270
>M74718-1|AAA60310.1| 495|Homo sapiens SEF2-1A protein protein.
Length = 495
Score = 30.7 bits (66), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Frame = -2
Query: 406 PRNYYNYDSSHSADVWTSAAVVVEVPAQTCPSRSAH---RAAIARLHPHKGVSLASPGS 239
P +++ D HS+D W+S++ + + S+H ++ LHPH+ +S S S
Sbjct: 36 PSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS 94
>BC125085-1|AAI25086.1| 667|Homo sapiens transcription factor 4
protein.
Length = 667
Score = 30.7 bits (66), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Frame = -2
Query: 406 PRNYYNYDSSHSADVWTSAAVVVEVPAQTCPSRSAH---RAAIARLHPHKGVSLASPGS 239
P +++ D HS+D W+S++ + + S+H ++ LHPH+ +S S S
Sbjct: 212 PSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS 270
>BC125084-1|AAI25085.1| 671|Homo sapiens TCF4 protein protein.
Length = 671
Score = 30.7 bits (66), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Frame = -2
Query: 406 PRNYYNYDSSHSADVWTSAAVVVEVPAQTCPSRSAH---RAAIARLHPHKGVSLASPGS 239
P +++ D HS+D W+S++ + + S+H ++ LHPH+ +S S S
Sbjct: 212 PSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS 270
>AB209741-1|BAD92978.1| 435|Homo sapiens transcription factor 4
isoform b variant protein.
Length = 435
Score = 30.7 bits (66), Expect = 5.8
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Frame = -2
Query: 406 PRNYYNYDSSHSADVWTSAAVVVEVPAQTCPSRSAH---RAAIARLHPHKGVSLASPGS 239
P +++ D HS+D W+S++ + + S+H ++ LHPH+ +S S S
Sbjct: 97 PSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS 155
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 76,249,640
Number of Sequences: 237096
Number of extensions: 1155309
Number of successful extensions: 3400
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 3235
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3388
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8903143626
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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