Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NV021136
(805 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 217 2e-55
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 151 3e-35
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 125 1e-27
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 121 2e-26
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 118 2e-25
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 117 3e-25
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 113 6e-24
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 112 9e-24
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 109 8e-23
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 109 1e-22
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 101 3e-20
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 99 1e-19
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 92 2e-17
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 91 4e-17
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 89 2e-16
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 81 3e-14
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 79 1e-13
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 76 9e-13
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 74 5e-12
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 69 1e-10
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 67 4e-10
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 63 7e-09
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 62 2e-08
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 58 2e-07
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 56 1e-06
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 56 1e-06
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 55 2e-06
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 55 2e-06
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 50 7e-05
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 47 5e-04
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 46 8e-04
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 46 0.001
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 46 0.001
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 43 0.010
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 43 0.010
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 42 0.014
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 42 0.024
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 41 0.032
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 41 0.042
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 40 0.097
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 40 0.097
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 37 0.52
UniRef50_Q5D2M9 Cluster: Eisenstasin I; n=1; Eisenia andrei|Rep:... 37 0.68
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 36 1.2
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 36 1.2
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 36 1.6
UniRef50_Q9KIZ5 Cluster: EpoF; n=2; Sorangium cellulosum|Rep: Ep... 35 2.1
UniRef50_A7EJZ1 Cluster: Putative uncharacterized protein; n=1; ... 35 2.8
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 35 2.8
UniRef50_A5E2P5 Cluster: Putative uncharacterized protein; n=1; ... 34 4.8
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 33 6.4
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 33 6.4
UniRef50_A7H6Q2 Cluster: N-acetyl-gamma-glutamyl-phosphate reduc... 33 8.4
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 217 bits (531), Expect = 2e-55
Identities = 115/192 (59%), Positives = 137/192 (71%), Gaps = 7/192 (3%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 430
G+R CTLIPGDGVGPELV +QEVFK+A +PVDFE +F SEVNP LSA LEDV+ SI
Sbjct: 37 GNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAKLEDVIASIRK 96
Query: 431 NKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHH--- 601
NK+CIKG+LATPD+S+ GELQ+LNMK L Y+ V+ R + PG +
Sbjct: 97 NKVCIKGVLATPDYSNVGELQSLNMKLRN----ELDLYANVVHARSL--PGVKTRYQDID 150
Query: 602 ----QRTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKA 769
+ EYSALEHESVPG+VECLKIITA KS RIAKFAFDYA+K+ ++ KA
Sbjct: 151 IVVIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTSVHKA 210
Query: 770 NIMKLGDGLFLR 805
NIMKLGDGLFL+
Sbjct: 211 NIMKLGDGLFLK 222
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 151 bits (365), Expect = 3e-35
Identities = 88/187 (47%), Positives = 119/187 (63%), Gaps = 8/187 (4%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICI 445
T++PGDGVGPEL++AV+EVFKAA++PV+F+ SEV N LE V++S+ NK+ I
Sbjct: 52 TMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAI 111
Query: 446 KGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHH-------Q 604
G + TP + GEL + +M+ L ++ V+ + + PG H+ +
Sbjct: 112 IGKIHTP-MEYKGELASYDMRLRRK----LDLFANVVHVKSL--PGYMTRHNNLDLVIIR 164
Query: 605 RTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKL 784
EYS+LEHES GV+ECLKI+T AKS+RIAKFAFDYA K G + KANIMKL
Sbjct: 165 EQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKL 224
Query: 785 GDGLFLR 805
GDGLFL+
Sbjct: 225 GDGLFLQ 231
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 125 bits (302), Expect = 1e-27
Identities = 79/184 (42%), Positives = 108/184 (58%), Gaps = 1/184 (0%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 430
G R TLIPGDGVG E+ +V ++F+ +IP+D+E+ S + T + ++ V S+
Sbjct: 27 GGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTEN--VQRAVESLKR 84
Query: 431 NKICIKGILATP-DFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQR 607
NK+ +KGI TP D + G L K + IF + I + + + +
Sbjct: 85 NKVGLKGIWHTPADQTGHGSLNVALRKQLD--IFANVALFKSIPGVKTRLNNIDMVIIRE 142
Query: 608 TDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLG 787
EYS LEHESVPGVVE LKI+T AKSERIA+FAFD+A+K+ + KANIMKLG
Sbjct: 143 NTEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKANIMKLG 202
Query: 788 DGLF 799
DGLF
Sbjct: 203 DGLF 206
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 121 bits (291), Expect = 2e-26
Identities = 74/184 (40%), Positives = 105/184 (57%), Gaps = 1/184 (0%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 430
G R TLIPGDGVG E+ +V+ +F+A +IP+D+E+ + + + + V S+
Sbjct: 26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDH--KEGVYEAVESLKR 83
Query: 431 NKICIKGILATP-DFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQR 607
NKI +KG+ TP D + G L K + I+ + + + + P L +
Sbjct: 84 NKIGLKGLWHTPADQTGHGSLNVALRKQLD--IYANVALFKSLKGVKTRIPDIDLIVIRE 141
Query: 608 TDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLG 787
E+S LEHESVPGVVE LK++T K+ERIA+FAFD+A K + KANIMKLG
Sbjct: 142 NTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLG 201
Query: 788 DGLF 799
DGLF
Sbjct: 202 DGLF 205
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 118 bits (283), Expect = 2e-25
Identities = 81/195 (41%), Positives = 113/195 (57%), Gaps = 10/195 (5%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 430
G R T+IPGDG+GPEL+ V+ VF+ A +PVDFE EV+ + +A ED+ N+I
Sbjct: 52 GGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSSNADEEDIRNAIMA 106
Query: 431 ---NKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHH 601
N++ +KG + T +H + +++ +L Y+ VI + + PG H
Sbjct: 107 IRRNRVALKGNIET---NHNLPPSHKSRNNILRT--SLDLYANVIHCKSL--PGVVTRHK 159
Query: 602 -------QRTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRR 760
+ EYS+LEHESV GVVE LKIIT AKS RIA++AF A + G ++
Sbjct: 160 DIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAV 219
Query: 761 PKANIMKLGDGLFLR 805
KANIMKLGDGLFL+
Sbjct: 220 HKANIMKLGDGLFLQ 234
Score = 36.3 bits (80), Expect = 0.90
Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 1/72 (1%)
Frame = +3
Query: 549 KSLPNVKCRHQDVDCIIIREQTE-ESTQLWNMNPFPAWWSV*RSSPQRNPSVLRNSLSTT 725
KSLP V RH+D+D +I+RE TE E + L + + S+ + ++ + +
Sbjct: 149 KSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLA 208
Query: 726 P*KMGRKKVTAV 761
+ GRKKVTAV
Sbjct: 209 Q-ESGRKKVTAV 219
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 117 bits (282), Expect = 3e-25
Identities = 77/185 (41%), Positives = 105/185 (56%), Gaps = 7/185 (3%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIK 448
TLIPGDG+GP + AV++V +A PV FE + EV + E+V+ S+ NK+C+K
Sbjct: 42 TLIPGDGIGPLVTGAVEQVMEAMHAPVHFERY---EVLGNMRKVPEEVIESVKRNKVCLK 98
Query: 449 GILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHH-------QR 607
G LATP G + +LNM+ L ++ ++ + PG H +
Sbjct: 99 GGLATPV---GGGVSSLNMQLRKE----LDIFASLV--NCINVPGLVTRHENVDIVVIRE 149
Query: 608 TDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLG 787
EYS LEHE VPGVVE LK+IT SERIA++AF+YA + ++ KANIMKL
Sbjct: 150 NTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLA 209
Query: 788 DGLFL 802
DGLFL
Sbjct: 210 DGLFL 214
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 113 bits (271), Expect = 6e-24
Identities = 69/178 (38%), Positives = 99/178 (55%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIK 448
TLIPGDG+GP + AV++V +A P+ FE + +V+ +S +V+ SI NK+C+K
Sbjct: 41 TLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKY---DVHGEMSRVPPEVMESIRKNKVCLK 97
Query: 449 GILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRTDRREYS 628
G L TP L K + + + ++ + + + + EY+
Sbjct: 98 GGLKTPVGGGVSSLNVQLRKELDLFASLVNCFN--LPGLPTRHENVDIVVIRENTEGEYA 155
Query: 629 ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLFL 802
LEHE VPGVVE LK+IT SERIAK+AF+YA + ++ KANIMKL DGLFL
Sbjct: 156 GLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFL 213
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 112 bits (270), Expect = 9e-24
Identities = 71/196 (36%), Positives = 110/196 (56%), Gaps = 11/196 (5%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVN----PTLSAPLEDVVN 418
G R TLIPGDG+GPE+V AVQ++F+ +PVDFE S ++ + + +
Sbjct: 48 GGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107
Query: 419 SIAVNKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHH 598
SI N + +KG + TP + G ++LN++ + L ++ ++ + + PG H
Sbjct: 108 SIKRNGVAMKGNIFTPLDAIPG-FRSLNLELRVH----LDLFANIVRCKSI--PGIQTRH 160
Query: 599 H-------QRTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDR 757
+ ++ EYS LEHE+V GV+E LK+ T +IA++AFD+A K ++
Sbjct: 161 NNVDLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQYAFDFAEKHDRKKVTA 220
Query: 758 RPKANIMKLGDGLFLR 805
KANIMK+GDGLFLR
Sbjct: 221 VHKANIMKMGDGLFLR 236
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 109 bits (262), Expect = 8e-23
Identities = 69/194 (35%), Positives = 108/194 (55%), Gaps = 10/194 (5%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--PLEDVVNSI 424
G R T++PG G+GPEL+ V+E+F+ P+DFE +++P+ L+ + SI
Sbjct: 55 GGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVI---DIDPSTEGNDDLDYAITSI 111
Query: 425 AVNKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHH- 601
N + +KG + T S T + + +++ L Y V+ + PG HH
Sbjct: 112 KRNGVALKGNIETKSQSLTEVSRNVAIRN------ELDLYVNVVHCKSY--PGIPARHHD 163
Query: 602 -------QRTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRR 760
Q TD EY+ LEHESVPG+VE +K++T +ER+A++AF++A ++ ++
Sbjct: 164 IDVVLIRQNTDG-EYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQNNRKKVTTI 222
Query: 761 PKANIMKLGDGLFL 802
KANIMKL DGLFL
Sbjct: 223 HKANIMKLSDGLFL 236
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 109 bits (261), Expect = 1e-22
Identities = 71/184 (38%), Positives = 102/184 (55%), Gaps = 2/184 (1%)
Frame = +2
Query: 260 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDF-ESFFFSEVNPTLSAPLE-DVVNSIAVN 433
IK TL PGDG+GPE+ +V++VF AA + +D+ E F +EV+P ++ L D + S+ N
Sbjct: 44 IKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKN 103
Query: 434 KICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRTD 613
K+ +KG +ATP L K + + YS + + + L +
Sbjct: 104 KVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYS--LPGYKTRYDDVDLITIRENT 161
Query: 614 RREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDG 793
EYS LEH+ V GVVE LKIIT S R+A++AF YA G ++ KANIM+ DG
Sbjct: 162 EGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDG 221
Query: 794 LFLR 805
LFL+
Sbjct: 222 LFLQ 225
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 101 bits (241), Expect = 3e-20
Identities = 70/195 (35%), Positives = 106/195 (54%), Gaps = 11/195 (5%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--PLEDVVNSI 424
G R T++PG G+GPEL+ V+EVF+ A +PVDFE +++P LE + SI
Sbjct: 47 GGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVV---DIDPASEGNDDLEYAITSI 103
Query: 425 AVNKICIKGILATPDFSHTGEL-QTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHH 601
N + +KG + T + TG + + + +++ L Y V+ + A HH
Sbjct: 104 KRNGVALKGNIETKSEA-TGIISRNVALRN------ELDLYVNVLHCKSFNAIPA---HH 153
Query: 602 QRTD--------RREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDR 757
Q D EY+ LEHESV GVVE +K++T + R+A++AF++A + ++
Sbjct: 154 QNVDVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFARANNRKKVTT 213
Query: 758 RPKANIMKLGDGLFL 802
KANIMKL DGLFL
Sbjct: 214 IHKANIMKLADGLFL 228
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 99.1 bits (236), Expect = 1e-19
Identities = 69/184 (37%), Positives = 98/184 (53%), Gaps = 3/184 (1%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF-SEVNPTLSAPLEDVVN-SIAVNK 436
K TLIPGDG+GPE+ A V +A + ++ESF +E + +N SI +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 437 ICIKGILATPDFSHTGELQTLNMKSVMPW-IFTLTWYSEVIAQREVQAPGRGLHHHQRTD 613
I +KG + TP G ++N++ + ++ + + PG L +
Sbjct: 64 IGLKGPVTTPI---GGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENT 120
Query: 614 RREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDG 793
YS +EHE VPGVVE LKIIT S RI+KFAF+YA K G ++ KANIMK+ DG
Sbjct: 121 EGLYSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIHSIHKANIMKMSDG 180
Query: 794 LFLR 805
LF+R
Sbjct: 181 LFIR 184
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 91.9 bits (218), Expect = 2e-17
Identities = 66/195 (33%), Positives = 101/195 (51%), Gaps = 9/195 (4%)
Frame = +2
Query: 245 NKGSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV---NPTLSAPLEDVV 415
+ G + TLIPGDG+GPE+ +VQ++F+AA P+ ++ + V + P +
Sbjct: 20 SSGDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSR-CI 78
Query: 416 NSIAVNKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLH 595
+ NK+ +KG L TP L K F+L Y+ V R ++ + L+
Sbjct: 79 ELMHANKVGLKGPLETPIGKGHRSLNLAVRKE-----FSL--YANVRPCRSLEGH-KTLY 130
Query: 596 HH------QRTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDR 757
+ + EYS +EHE VPGVV+ +K+IT S +A FAF+YA ++G +
Sbjct: 131 DNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTA 190
Query: 758 RPKANIMKLGDGLFL 802
KANIM+ DGLFL
Sbjct: 191 VHKANIMRQSDGLFL 205
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 90.6 bits (215), Expect = 4e-17
Identities = 63/192 (32%), Positives = 94/192 (48%), Gaps = 2/192 (1%)
Frame = +2
Query: 236 TEGNKGSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--ED 409
T G G TLIPGDG+GPE+ AV ++F AA P+ +E + + + +
Sbjct: 24 TRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSE 83
Query: 410 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRG 589
S+ NK+ +KG L TP + + L K+ + S I +
Sbjct: 84 AKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVS--IEGYKTPYTDVN 141
Query: 590 LHHHQRTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKA 769
+ + EYS +EH V GVV+ +K+IT S+RIA+FAF+YA + KA
Sbjct: 142 IVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKA 201
Query: 770 NIMKLGDGLFLR 805
NIM++ DGLFL+
Sbjct: 202 NIMRMSDGLFLQ 213
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 88.6 bits (210), Expect = 2e-16
Identities = 60/180 (33%), Positives = 93/180 (51%), Gaps = 2/180 (1%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE--VNPTLSAPLEDVVNSIAVNKIC 442
+ I GDG+GPE+ +V+++F AA++P+++ES S VN + P + V SI N +
Sbjct: 40 SFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIP-DPAVQSITKNLVA 98
Query: 443 IKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRTDRRE 622
+KG LATP L K+ +F ++ I + L + E
Sbjct: 99 LKGPLATPIGKGHRSLNLTLRKTF--GLFANVRPAKSIEGFKTTYENVDLVLIRENTEGE 156
Query: 623 YSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLFL 802
YS +EH PGVV+ +K+IT SER+ ++AF+YA G K+ I +L DGLF+
Sbjct: 157 YSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFV 216
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 81.0 bits (191), Expect = 3e-14
Identities = 53/140 (37%), Positives = 79/140 (56%), Gaps = 8/140 (5%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICI 445
T++PGDGVGPEL++AV+EVFKAA++PV+F+ SEV N LE V++S+ NK+ I
Sbjct: 52 TMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAI 111
Query: 446 KGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHH-------Q 604
G + TP + GEL + +M+ L ++ V+ + + PG H+ +
Sbjct: 112 IGKIHTP-MEYKGELASYDMRLRR----KLDLFANVVHVKSL--PGYMTRHNNLDLVIIR 164
Query: 605 RTDRREYSALEHESVPGVVE 664
EYS+LEHE V E
Sbjct: 165 EQTEGEYSSLEHECCEEVAE 184
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 79.4 bits (187), Expect = 1e-13
Identities = 40/81 (49%), Positives = 57/81 (70%), Gaps = 1/81 (1%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICI 445
T++PGDGVGPEL++AV+EVFKAAS+PV+F+ SEV N LE V++S+ NK+ I
Sbjct: 20 TMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAI 79
Query: 446 KGILATPDFSHTGELQTLNMK 508
G + TP + GEL + +M+
Sbjct: 80 IGKIHTP-MEYKGELASYDMR 99
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 76.2 bits (179), Expect = 9e-13
Identities = 60/180 (33%), Positives = 91/180 (50%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 442
K TLI G+GVG EL+ AVQEV A P++++ + + E V+ S+ NK+
Sbjct: 71 KVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPE-VLKSLRANKVG 129
Query: 443 IKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRTDRRE 622
IKG P S + Q + ++ +L + E + + D
Sbjct: 130 IKG----PVDSRHWQRQIRKQFAQFAYV-SLCSHIEGLDSPYGDFDVVIIRDQMEGD--- 181
Query: 623 YSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLFL 802
YS +EH VPGV++ +K+ T A + RIA+F F+YAVK+ + KANIM++ DG FL
Sbjct: 182 YSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFL 241
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 73.7 bits (173), Expect = 5e-12
Identities = 62/189 (32%), Positives = 99/189 (52%), Gaps = 10/189 (5%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFE--SFFFSEVNPTLSAPL-EDVVNSIAVNKI 439
T+IPGDG+GPE V A +V +AA P+ +E S +++ + ++ + SI ++
Sbjct: 23 TVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKTRV 82
Query: 440 CIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQRE---VQAP--GRGLHHHQ 604
+KG L TP GE ++ N+ + +F Y+ V RE V P GRG+
Sbjct: 83 VLKGPLETP--VGYGE-KSANV--TLRKLFET--YANVRPVREFPNVPTPYAGRGIDLVV 135
Query: 605 RTDRRE--YSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIM 778
+ E Y+ +EH P V + LK+I+ SE+I +FAF+ A +G ++ K+NIM
Sbjct: 136 VRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIM 195
Query: 779 KLGDGLFLR 805
KL +G R
Sbjct: 196 KLAEGTLKR 204
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 68.9 bits (161), Expect = 1e-10
Identities = 50/183 (27%), Positives = 85/183 (46%), Gaps = 3/183 (1%)
Frame = +2
Query: 260 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE--VNPTLSAPL-EDVVNSIAV 430
I T+ GDG+GPE++ AV V K A++P+ E+ E N + + ED + I
Sbjct: 5 IPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFR 64
Query: 431 NKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRT 610
K +KG + TP L + ++ + + AP + +
Sbjct: 65 TKALLKGPVTTPQGGGYKSLN-VTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIREN 123
Query: 611 DRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGD 790
+ Y+ +E+ E +K+I+ + SE+I +FAF+YA+K+ + K NIMK D
Sbjct: 124 EEDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTD 183
Query: 791 GLF 799
G+F
Sbjct: 184 GIF 186
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 67.3 bits (157), Expect = 4e-10
Identities = 37/62 (59%), Positives = 43/62 (69%)
Frame = +2
Query: 620 EYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLF 799
EYS LEHESV GV E LKI+T AKS RIA++AF A K G ++ K NI KLGDG F
Sbjct: 40 EYSNLEHESVKGVTESLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPF 99
Query: 800 LR 805
L+
Sbjct: 100 LQ 101
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 63.3 bits (147), Expect = 7e-09
Identities = 63/193 (32%), Positives = 91/193 (47%), Gaps = 11/193 (5%)
Frame = +2
Query: 257 RIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIAV 430
+I TLIPGDG+GPE+V V VF A P +E+ S L + ++SI
Sbjct: 9 QIPVTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQTTLDSIGR 68
Query: 431 NKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGR----GLHH 598
+ +KG L+TP G +++N++ + F L Y+ V R + GR L
Sbjct: 69 TGLALKGPLSTP---IGGGFRSVNVR--LRETFQL--YANVRPARTIVPGGRYEKIDLVL 121
Query: 599 HQRTDRREYSALEH-----ESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRP 763
+ Y EH + V I T A S RI+KFAFDYAV++ ++
Sbjct: 122 VRENLEGLYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRKVTIVH 181
Query: 764 KANIMKLGDGLFL 802
KAN++K GLFL
Sbjct: 182 KANVLKALTGLFL 194
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 62.1 bits (144), Expect = 2e-08
Identities = 61/201 (30%), Positives = 95/201 (47%), Gaps = 20/201 (9%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFS-EVNPTLSAPL-EDVVNSIAVNK 436
+ TLIPGDG+GPE+ A+ V +A+ + +++ EV PL V+ SI +
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEAGVEVIEKYGTPLPPQVLESIRETR 63
Query: 437 ICIKGILATP--------DFSHTGELQ---TLNMKSVMPWIFTLTWYSEVIAQRE-VQAP 580
+ IKG + TP + + EL L +P I + +++ RE +
Sbjct: 64 VAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENTEDL 123
Query: 581 GRGLHHHQRTD-----RREYSALEHESV-PGVVECLKIITAAKSERIAKFAFDYAVKDGP 742
G+ + T R E L + + G +K I+ S RI KFAF+YA ++G
Sbjct: 124 YAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYARQNGR 183
Query: 743 QEGDRRPKANIMKLGDGLFLR 805
++ KANIMK DGLFL+
Sbjct: 184 KKVTAVHKANIMKFTDGLFLQ 204
Score = 33.9 bits (74), Expect = 4.8
Identities = 12/24 (50%), Positives = 18/24 (75%)
Frame = +3
Query: 549 KSLPNVKCRHQDVDCIIIREQTEE 620
KSLP +K QD+D +++RE TE+
Sbjct: 99 KSLPGIKSPFQDIDLVVVRENTED 122
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 58.4 bits (135), Expect = 2e-07
Identities = 52/186 (27%), Positives = 84/186 (45%), Gaps = 9/186 (4%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV---NPTLSAPLEDVVNSIAVNKI 439
T+ GDG+GPE++ AV + + A + E+ E S E+ SI I
Sbjct: 8 TIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTGI 67
Query: 440 CIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQR-TDR 616
+K + TP G ++LN+ TL ++ + LH H T
Sbjct: 68 ILKAPITTPQ---GGGYKSLNVTIRK----TLQLFANIRPSVSFHPFTMTLHPHLNLTII 120
Query: 617 RE-----YSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMK 781
RE Y+ +E+ + E +K+I+ E+I ++AF+YAVK+ ++ K NIMK
Sbjct: 121 RENEEDLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMK 180
Query: 782 LGDGLF 799
DG+F
Sbjct: 181 FSDGVF 186
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 56.0 bits (129), Expect = 1e-06
Identities = 30/62 (48%), Positives = 42/62 (67%)
Frame = +2
Query: 620 EYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLF 799
EYS LE ES+ VVE L+ +T AK R+A++AF A + G ++ KANIM+LGD LF
Sbjct: 50 EYSNLEDESMNRVVESLRTVTKAKCLRLAEYAFQLAHRMGCKKVTATYKANIMRLGDCLF 109
Query: 800 LR 805
++
Sbjct: 110 IQ 111
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 56.0 bits (129), Expect = 1e-06
Identities = 30/69 (43%), Positives = 44/69 (63%), Gaps = 3/69 (4%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 430
G R T+IPGDG+GPEL+ V+ VF+ A +PVDFE EV+ + +A ED+ N+I
Sbjct: 25 GGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSSNADEEDICNAIMA 79
Query: 431 ---NKICIK 448
N++ +K
Sbjct: 80 IRRNRVALK 88
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 55.2 bits (127), Expect = 2e-06
Identities = 27/71 (38%), Positives = 43/71 (60%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 430
G R TLIPGDG+GPEL+ V+E+F+ + +PVDFE + + T + + + +I
Sbjct: 48 GGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS-SSTSEDDISNAIMAIRR 106
Query: 431 NKICIKGILAT 463
N + +KG + T
Sbjct: 107 NGVALKGNIET 117
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 55.2 bits (127), Expect = 2e-06
Identities = 48/184 (26%), Positives = 78/184 (42%), Gaps = 5/184 (2%)
Frame = +2
Query: 260 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE---VNPTLSAPLEDVVNSIAV 430
+ T+ GDGVGPE++ AV + K A V E+ S SI+
Sbjct: 8 VPITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISR 67
Query: 431 NKICIKGILATPDFSHTGELQTLNMKSVMPWIFT--LTWYSEVIAQREVQAPGRGLHHHQ 604
++ +K TP S L + + ++ Y V+ + P + +
Sbjct: 68 TRLLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSYFPVVGTKH---PDLDVVIIR 124
Query: 605 RTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKL 784
+ YS +EH+ EC+KI T + SE+I +AF+YA ++ K NIMK+
Sbjct: 125 ENEEDTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKM 184
Query: 785 GDGL 796
DG+
Sbjct: 185 TDGI 188
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 50.0 bits (114), Expect = 7e-05
Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 1/140 (0%)
Frame = +2
Query: 311 AVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGEL 490
AV +V A PV FE++ N ++ +VV+SI NK+C+ G + G
Sbjct: 15 AVHQVMDAMQAPVYFETYIIKGKN--MNHLTWEVVDSIRKNKVCLNGRVNNSLCG--GAR 70
Query: 491 QTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRTDRREYSALEHESVPGVVECL 670
+ L++ + + F L ++ + EY+ EHE VPGV+E
Sbjct: 71 KELDLFASLVDCFNLNGQPSRHENVDIVVI-------RENTEGEYAGREHEVVPGVIESF 123
Query: 671 KI-ITAAKSERIAKFAFDYA 727
++ +T S+RIAK+AF+YA
Sbjct: 124 QVTMTKFWSDRIAKYAFEYA 143
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 47.2 bits (107), Expect = 5e-04
Identities = 26/69 (37%), Positives = 38/69 (55%), Gaps = 1/69 (1%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 439
K TLIPGDGVGPE+ A ++ A + +D++ EV + V++SI NKI
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANKI 62
Query: 440 CIKGILATP 466
+K + TP
Sbjct: 63 ALKAPITTP 71
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 46.4 bits (105), Expect = 8e-04
Identities = 46/181 (25%), Positives = 78/181 (43%), Gaps = 2/181 (1%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 442
K +IPGDG+G E++ A + + +P FE ++ + L + + + + C
Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKLDLP--FEYSYYDAGDEALEKYGKALPDETL--EAC 58
Query: 443 IKGILATPDFSHTGELQTLNMKSVMPWIFTLTWY--SEVIAQREVQAPGRGLHHHQRTDR 616
K F GE + + + T ++ I E PG + +
Sbjct: 59 RKSDAVL--FGAAGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTE 116
Query: 617 REYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGL 796
Y E V E +++IT SERIA++AF+ A ++G ++ KAN+MK GL
Sbjct: 117 CLYMGFEF-GFGDVTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMKKTCGL 175
Query: 797 F 799
F
Sbjct: 176 F 176
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 46.0 bits (104), Expect = 0.001
Identities = 23/55 (41%), Positives = 32/55 (58%)
Frame = +2
Query: 635 EHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLF 799
+ E P +IIT S RI++FAF YA K+G Q+ KAN++K DG+F
Sbjct: 124 DEEYTPEGAVAKRIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIF 178
Score = 35.5 bits (78), Expect = 1.6
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +3
Query: 546 VKSLPNVKCRHQDVDCIIIREQTEE 620
VKSLP V C + D+D +I+RE TE+
Sbjct: 95 VKSLPGVPCLYPDLDFVIVRENTED 119
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 46.0 bits (104), Expect = 0.001
Identities = 20/44 (45%), Positives = 32/44 (72%)
Frame = +2
Query: 671 KIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLFL 802
++IT SERI +FAF+YA+K+ ++ KAN++++ DGLFL
Sbjct: 150 RVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFL 193
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 42.7 bits (96), Expect = 0.010
Identities = 50/192 (26%), Positives = 82/192 (42%), Gaps = 14/192 (7%)
Frame = +2
Query: 272 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTL--SAPLEDVVNSIAVNKICI 445
++ G+G+GPE+ A V +A I +++ ++ L A V+ I K CI
Sbjct: 5 VLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVKFCI 64
Query: 446 KG-ILATPDFSHTGELQTLNMKSVMPWIFTLTW--YSEVIAQREVQAPGRGLHHHQRTDR 616
K +LA QT P I + + R ++ H++ D
Sbjct: 65 KAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEKMDM 124
Query: 617 ---RE-----YSALEHESVPGVV-ECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKA 769
RE Y E G E +K +T + S +++++AF+YA K G ++ KA
Sbjct: 125 VIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKA 184
Query: 770 NIMKLGDGLFLR 805
N++ DGLFLR
Sbjct: 185 NVLHETDGLFLR 196
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 42.7 bits (96), Expect = 0.010
Identities = 52/186 (27%), Positives = 81/186 (43%), Gaps = 7/186 (3%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 439
K +I GDG+G E+V A +V +A +P +F + EV L + A++
Sbjct: 3 KICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGKALPEETIETALD-- 60
Query: 440 CIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRTDRR 619
C +L F GE + + + T V A + V+ + + +
Sbjct: 61 C-DAVL----FGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENT 115
Query: 620 E--YSALEHESVPGVVECLKIITAAKSERIAKFAFDYA--VKDGPQEG--DRRPKANIMK 781
E Y +E E G+ ++IT ERI +FAF+ A K +EG KAN++K
Sbjct: 116 EGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAHKANVLK 175
Query: 782 LGDGLF 799
L DGLF
Sbjct: 176 LTDGLF 181
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 42.3 bits (95), Expect = 0.014
Identities = 22/45 (48%), Positives = 31/45 (68%)
Frame = +2
Query: 668 LKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLFL 802
+K I++ SERIA+FAF+YA + ++ KANI+K DGLFL
Sbjct: 160 VKPISSEASERIARFAFEYARRHARRKVTAVHKANILKHTDGLFL 204
Score = 38.3 bits (85), Expect = 0.22
Identities = 27/75 (36%), Positives = 37/75 (49%), Gaps = 4/75 (5%)
Frame = +2
Query: 254 SRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF---SEVNPTLSAPL-EDVVNS 421
S + TLI GDG+GPE+ A + V A I DFE +EV PL V+ +
Sbjct: 2 SPYRVTLIRGDGIGPEVTQAARIVLDATGI--DFEWVVVDAGAEVMEKSGTPLPAPVIEA 59
Query: 422 IAVNKICIKGILATP 466
+ + IKG + TP
Sbjct: 60 VRASDAAIKGPITTP 74
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 41.5 bits (93), Expect = 0.024
Identities = 42/177 (23%), Positives = 67/177 (37%)
Frame = -1
Query: 799 EQSVAQLHDVGLGTAVTFLRPIFHGVVESEFRNTLGFRCGDDLQTLHHAGNGFMFXXXXX 620
EQ+++Q HD+GL L + G V+ + ++LGF G DL L+H +F
Sbjct: 34 EQTISQFHDIGLVDGGDQLTVVLLGKVKCKLGDSLGFEPGHDLHRLNHTRVRLVFQSRIF 93
Query: 619 XXXXXXXXXXSTSWCLHFTLGNDFTVPR*RKDPXXXXXXXXXXXLASVREVRSG*DTLDT 440
+ GN F + K+ + R S DT +
Sbjct: 94 TFSVFSDEGKVNALQTRLDAGNVFDQDQRSKN--IQFFSQRNIQRFAGRSSWSKQDTFQS 151
Query: 439 NLVNSDRVYDVFEWCTKCWIHFRKEKGFKVHWNAGRLENFLYSVDKLRTYTVPRNQG 269
+LV+ R + + T + R F + RLEN L + T T+ N+G
Sbjct: 152 HLVSLQRFHSLGNPGT--LVQTRNINSFPFDGDVFRLENGLDGIGDFLTNTISWNEG 206
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 41.1 bits (92), Expect = 0.032
Identities = 24/59 (40%), Positives = 34/59 (57%)
Frame = +2
Query: 623 YSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLF 799
Y EH GV +KIIT SERIAK ++A++ ++ KAN+M++ DGLF
Sbjct: 124 YKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALR-RRKKVTCVHKANVMRITDGLF 181
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 40.7 bits (91), Expect = 0.042
Identities = 16/27 (59%), Positives = 21/27 (77%)
Frame = +2
Query: 269 TLIPGDGVGPELVYAVQEVFKAASIPV 349
TLIPGDG+GPE+ AV ++F AA P+
Sbjct: 8 TLIPGDGIGPEISAAVMKIFDAAKAPI 34
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 39.5 bits (88), Expect = 0.097
Identities = 20/44 (45%), Positives = 26/44 (59%)
Frame = +2
Query: 671 KIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMKLGDGLFL 802
K+IT SERI + AFDYA ++ KAN++K DG FL
Sbjct: 160 KVITTQGSERIIRLAFDYARRNNINRVSVVTKANVVKTTDGKFL 203
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 39.5 bits (88), Expect = 0.097
Identities = 23/58 (39%), Positives = 32/58 (55%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSI 424
G + T+ PGDG GPEL+ V +A +PVDFE EV + +A ED+ S+
Sbjct: 13 GGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFE-----EVVVSSNADEEDIRTSL 65
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 37.1 bits (82), Expect = 0.52
Identities = 15/27 (55%), Positives = 20/27 (74%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFK 331
G R T+IPGDG+GPEL+ V+ VF+
Sbjct: 110 GGRHTVTMIPGDGIGPELMLHVKSVFR 136
>UniRef50_Q5D2M9 Cluster: Eisenstasin I; n=1; Eisenia andrei|Rep:
Eisenstasin I - Eisenia andrei
Length = 156
Score = 36.7 bits (81), Expect = 0.68
Identities = 17/43 (39%), Positives = 21/43 (48%)
Frame = +2
Query: 161 CWKGCTHKFGNNREKCMLCTIWSPATEGNKGSRIKCTLIPGDG 289
CWK CTH F N+ C +C + S I+CTL DG
Sbjct: 50 CWKECTHGFLNDSRGCQVCAC-ARDPNAESCSAIECTLECSDG 91
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 35.9 bits (79), Expect = 1.2
Identities = 20/44 (45%), Positives = 26/44 (59%)
Frame = +2
Query: 245 NKGSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE 376
N + +IPGDG+GPELV + EV +AA+ D E F SE
Sbjct: 2 NAPHALDIAVIPGDGIGPELVRSAVEVLRAAA-GRDVELRFTSE 44
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 35.9 bits (79), Expect = 1.2
Identities = 48/187 (25%), Positives = 77/187 (41%), Gaps = 10/187 (5%)
Frame = +2
Query: 272 LIPGDGVGPELVYAVQEVFKAASIPVDF-----ESFFFSEVNPTLSAPLEDVVNSIAVNK 436
+I GDGVGPELV A+ +V AA V+F + ++ E P ++ + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVP-DETWQILDSSD 65
Query: 437 ICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQREVQAPGRGLHHHQRTDR 616
C KG TP + ++++ Y+ V + L +
Sbjct: 66 ACFKGPTTTPGGIGSPRSVAVSIRR------KYDLYANVRPIKTFPNSNAPLGDVEMVCV 119
Query: 617 RE-----YSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKDGPQEGDRRPKANIMK 781
RE Y E + V ++ IT S +IA++AF+ A + G K+NI+K
Sbjct: 120 REGTEGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPIHKSNILK 179
Query: 782 LGDGLFL 802
L G FL
Sbjct: 180 LTCGSFL 186
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 35.5 bits (78), Expect = 1.6
Identities = 16/38 (42%), Positives = 24/38 (63%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE 376
+ T++PGDG+GPE+ V +AA + ESF F+E
Sbjct: 40 RVTVLPGDGIGPEITAVTLSVLEAAG-KAEGESFTFTE 76
>UniRef50_Q9KIZ5 Cluster: EpoF; n=2; Sorangium cellulosum|Rep: EpoF
- Polyangium cellulosum (Sorangium cellulosum)
Length = 2439
Score = 35.1 bits (77), Expect = 2.1
Identities = 16/43 (37%), Positives = 23/43 (53%)
Frame = -1
Query: 343 NAGRLENFLYSVDKLRTYTVPRNQGAFDTTSFVALGCRAPNGA 215
NAG+LE+ L +DKL Q + + + +GCR P GA
Sbjct: 5 NAGKLEHALLLMDKLAKKNASLEQERTEPIAIIGIGCRFPGGA 47
>UniRef50_A7EJZ1 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 567
Score = 34.7 bits (76), Expect = 2.8
Identities = 20/63 (31%), Positives = 30/63 (47%)
Frame = +2
Query: 227 SPATEGNKGSRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLE 406
+P EG KG C + G G PEL+ QE + +P++ F + PTL +E
Sbjct: 497 APNKEGGKGVP-SCYWLFG-GTDPELIRKAQETGRMEDVPINHGPLFLPVIQPTLKTGVE 554
Query: 407 DVV 415
+V
Sbjct: 555 ILV 557
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 34.7 bits (76), Expect = 2.8
Identities = 48/189 (25%), Positives = 85/189 (44%), Gaps = 8/189 (4%)
Frame = +2
Query: 263 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE------SFFFSEVNPTLSAPLEDVVNSI 424
K +LI GDG+GPEL + V + +D + S + T A +D V++I
Sbjct: 3 KISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSAI 62
Query: 425 AVNKICIKGILATPDFSHTGELQTLNMKSVMPWIFTLTWYSEVIAQRE-VQAPGRGLHHH 601
+ C+K + L+ M + I Y + A R+ + +
Sbjct: 63 KQSDACMKAPVGESAADVIVVLR--RMLDLYANIRPAKSYPHMPALRDDIDMVIVRENTE 120
Query: 602 QRTDRREYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA-VKDGPQEGDRRPKANIM 778
+E+S L SV L+II+ S+RIAK+AF+ A +++ ++ K+N+M
Sbjct: 121 DLYTGKEFS-LGDSSV-----ALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNVM 174
Query: 779 KLGDGLFLR 805
++ DG+F +
Sbjct: 175 RVTDGMFAK 183
>UniRef50_A5E2P5 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 964
Score = 33.9 bits (74), Expect = 4.8
Identities = 17/56 (30%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Frame = +1
Query: 94 YQIQTCPFLAGIFFELLCRDLNMLERVYTQ---VR*QQRKMYVMHHLEPCNRGQQR 252
Y I TC F + IF + + + + YT+ + + +YV+HH CN+G +R
Sbjct: 802 YVIITCSFYSCIFIGITILNGGLEDEGYTESDLLTLLKNSVYVLHHYSTCNKGAER 857
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 33.5 bits (73), Expect = 6.4
Identities = 13/30 (43%), Positives = 21/30 (70%)
Frame = +2
Query: 251 GSRIKCTLIPGDGVGPELVYAVQEVFKAAS 340
G+ ++ ++PGDG+GPE+ A V +AAS
Sbjct: 10 GNVMQLIVLPGDGIGPEITTATSGVLRAAS 39
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 33.5 bits (73), Expect = 6.4
Identities = 13/30 (43%), Positives = 20/30 (66%)
Frame = +2
Query: 272 LIPGDGVGPELVYAVQEVFKAASIPVDFES 361
+IPGDG+G E++ A V +A +P FE+
Sbjct: 10 VIPGDGIGREVIPAAVAVLRATGLPFHFEN 39
>UniRef50_A7H6Q2 Cluster: N-acetyl-gamma-glutamyl-phosphate
reductase; n=3; Cystobacterineae|Rep:
N-acetyl-gamma-glutamyl-phosphate reductase -
Anaeromyxobacter sp. Fw109-5
Length = 354
Score = 33.1 bits (72), Expect = 8.4
Identities = 16/33 (48%), Positives = 18/33 (54%), Gaps = 1/33 (3%)
Frame = +2
Query: 575 APGRGLHHHQRTDR-REYSALEHESVPGVVECL 670
AP G HH R R Y LEH+ VP +VE L
Sbjct: 192 APSAGTHHPVRAGNLRTYKPLEHQHVPEIVETL 224
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 822,737,759
Number of Sequences: 1657284
Number of extensions: 17475357
Number of successful extensions: 44597
Number of sequences better than 10.0: 53
Number of HSP's better than 10.0 without gapping: 42735
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 44545
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 69143070360
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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