Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NRPG2002
(738 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 228 1e-59
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 228 1e-59
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 228 1e-59
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 228 1e-59
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 228 1e-59
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 228 1e-59
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 228 1e-59
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 197 3e-50
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 197 4e-50
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 197 4e-50
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 197 4e-50
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 186 7e-47
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 186 7e-47
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 186 7e-47
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 186 7e-47
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 186 7e-47
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 186 7e-47
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 186 7e-47
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 180 4e-45
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 180 4e-45
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 180 4e-45
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 180 4e-45
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 180 4e-45
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 180 4e-45
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 180 4e-45
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 180 4e-45
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 180 4e-45
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 180 5e-45
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 180 5e-45
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 169 9e-42
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 169 9e-42
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 169 9e-42
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 169 9e-42
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 169 9e-42
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 169 9e-42
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 168 2e-41
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 168 2e-41
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 166 6e-41
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 126 6e-29
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 72 2e-12
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 72 2e-12
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 72 2e-12
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 72 2e-12
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 72 2e-12
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 72 2e-12
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 72 2e-12
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 72 2e-12
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 72 2e-12
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 72 2e-12
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 72 2e-12
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 71 6e-12
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 66 9e-11
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 66 9e-11
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 66 9e-11
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 66 9e-11
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 66 9e-11
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 66 9e-11
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 66 9e-11
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 66 9e-11
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 64 5e-10
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 60 8e-09
AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinog... 58 4e-08
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 56 1e-07
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 56 1e-07
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 55 2e-07
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 42 0.002
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.002
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.002
AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant... 40 0.007
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 39 0.022
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 37 0.087
M11437-2|AAB59550.1| 644|Homo sapiens kininogen protein. 33 1.1
AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protei... 32 1.9
AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens ... 32 2.5
BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain cont... 31 5.7
BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member ... 25 7.2
AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens ... 25 7.2
BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated prot... 30 7.5
BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated prot... 30 7.5
AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated prot... 30 7.5
X85133-1|CAA59445.1| 948|Homo sapiens RB protein binding protei... 30 10.0
AY072922-1|AAL68925.1| 1625|Homo sapiens p53-associated cellular... 30 10.0
AK096194-1|BAC04723.1| 138|Homo sapiens protein ( Homo sapiens ... 30 10.0
AF352051-1|AAL05625.1| 1616|Homo sapiens proliferation potential... 30 10.0
AB126079-1|BAD20206.1| 202|Homo sapiens keratin associated prot... 30 10.0
AB112075-1|BAC77637.1| 1758|Homo sapiens retinoblastoma binding ... 30 10.0
AB112074-1|BAC77636.1| 1792|Homo sapiens retinoblastoma binding ... 30 10.0
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 228 bits (558), Expect = 1e-59
Identities = 122/222 (54%), Positives = 147/222 (66%), Gaps = 23/222 (10%)
Frame = +2
Query: 140 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 286
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 613
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 614 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFY
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFY 232
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 228 bits (558), Expect = 1e-59
Identities = 122/222 (54%), Positives = 147/222 (66%), Gaps = 23/222 (10%)
Frame = +2
Query: 140 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 286
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 613
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 614 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFY
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFY 232
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 228 bits (558), Expect = 1e-59
Identities = 122/222 (54%), Positives = 147/222 (66%), Gaps = 23/222 (10%)
Frame = +2
Query: 140 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 286
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 613
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 614 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFY
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFY 232
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 228 bits (558), Expect = 1e-59
Identities = 122/222 (54%), Positives = 147/222 (66%), Gaps = 23/222 (10%)
Frame = +2
Query: 140 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 286
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 613
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 614 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFY
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFY 232
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 228 bits (558), Expect = 1e-59
Identities = 122/222 (54%), Positives = 147/222 (66%), Gaps = 23/222 (10%)
Frame = +2
Query: 140 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 286
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 613
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 614 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFY
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFY 232
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 228 bits (558), Expect = 1e-59
Identities = 122/222 (54%), Positives = 147/222 (66%), Gaps = 23/222 (10%)
Frame = +2
Query: 140 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 286
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 613
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 614 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFY
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFY 232
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 228 bits (558), Expect = 1e-59
Identities = 122/222 (54%), Positives = 147/222 (66%), Gaps = 23/222 (10%)
Frame = +2
Query: 140 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 286
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 613
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 614 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFY
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFY 232
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 197 bits (481), Expect = 3e-50
Identities = 97/202 (48%), Positives = 132/202 (65%), Gaps = 6/202 (2%)
Frame = +2
Query: 149 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 313
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 314 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 493
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 494 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 673
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 674 VTPVFDNMVAQGLV-QPVFSFY 736
V P D +V QGL+ +PVFSFY
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFY 220
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 197 bits (480), Expect = 4e-50
Identities = 97/202 (48%), Positives = 132/202 (65%), Gaps = 6/202 (2%)
Frame = +2
Query: 149 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 313
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 314 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 493
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 494 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 673
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 674 VTPVFDNMVAQGLV-QPVFSFY 736
V P D +V QGL+ +PVFSFY
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFY 220
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 197 bits (480), Expect = 4e-50
Identities = 97/202 (48%), Positives = 132/202 (65%), Gaps = 6/202 (2%)
Frame = +2
Query: 149 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 313
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 314 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 493
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 494 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 673
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 674 VTPVFDNMVAQGLV-QPVFSFY 736
V P D +V QGL+ +PVFSFY
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFY 220
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 197 bits (480), Expect = 4e-50
Identities = 97/202 (48%), Positives = 132/202 (65%), Gaps = 6/202 (2%)
Frame = +2
Query: 149 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 313
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 314 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 493
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 494 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 673
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 674 VTPVFDNMVAQGLV-QPVFSFY 736
V P D +V QGL+ +PVFSFY
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFY 220
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 186 bits (453), Expect = 7e-47
Identities = 101/213 (47%), Positives = 135/213 (63%), Gaps = 11/213 (5%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 280
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 281 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 460
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 461 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 640
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 641 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFY 736
G+ + ++AV VTPVFDNM+AQ LV P+FS Y
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVY 218
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 186 bits (453), Expect = 7e-47
Identities = 101/213 (47%), Positives = 135/213 (63%), Gaps = 11/213 (5%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 280
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 281 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 460
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 461 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 640
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 641 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFY 736
G+ + ++AV VTPVFDNM+AQ LV P+FS Y
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVY 218
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 186 bits (453), Expect = 7e-47
Identities = 101/213 (47%), Positives = 135/213 (63%), Gaps = 11/213 (5%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 280
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 281 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 460
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 461 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 640
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 641 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFY 736
G+ + ++AV VTPVFDNM+AQ LV P+FS Y
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVY 218
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 186 bits (453), Expect = 7e-47
Identities = 101/213 (47%), Positives = 135/213 (63%), Gaps = 11/213 (5%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 280
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 281 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 460
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 461 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 640
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 641 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFY 736
G+ + ++AV VTPVFDNM+AQ LV P+FS Y
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVY 218
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 186 bits (453), Expect = 7e-47
Identities = 101/213 (47%), Positives = 135/213 (63%), Gaps = 11/213 (5%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 280
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 281 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 460
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 461 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 640
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 641 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFY 736
G+ + ++AV VTPVFDNM+AQ LV P+FS Y
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVY 218
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 186 bits (453), Expect = 7e-47
Identities = 101/213 (47%), Positives = 135/213 (63%), Gaps = 11/213 (5%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 280
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 281 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 460
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 461 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 640
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 641 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFY 736
G+ + ++AV VTPVFDNM+AQ LV P+FS Y
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVY 218
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 186 bits (453), Expect = 7e-47
Identities = 101/213 (47%), Positives = 135/213 (63%), Gaps = 11/213 (5%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 280
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 281 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 460
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 461 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 640
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 641 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFY 736
G+ + ++AV VTPVFDNM+AQ LV P+FS Y
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVY 218
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAQFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 180 bits (439), Expect = 4e-45
Identities = 82/151 (54%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Frame = +2
Query: 287 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 466
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 467 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 646
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 647 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFY 736
F A+ VTP+FDN+++QG L + VFSFY
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFY 227
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 180 bits (438), Expect = 5e-45
Identities = 88/195 (45%), Positives = 126/195 (64%), Gaps = 6/195 (3%)
Frame = +2
Query: 170 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 334
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 335 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 514
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 141
Query: 515 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDN 694
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 142 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 201
Query: 695 MVAQGLV-QPVFSFY 736
+V QGL+ +PVFSFY
Sbjct: 202 LVEQGLLDKPVFSFY 216
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 180 bits (438), Expect = 5e-45
Identities = 88/195 (45%), Positives = 126/195 (64%), Gaps = 6/195 (3%)
Frame = +2
Query: 170 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 334
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 335 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 514
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 145
Query: 515 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDN 694
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 146 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 205
Query: 695 MVAQGLV-QPVFSFY 736
+V QGL+ +PVFSFY
Sbjct: 206 LVEQGLLDKPVFSFY 220
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 169 bits (411), Expect = 9e-42
Identities = 92/200 (46%), Positives = 124/200 (62%), Gaps = 10/200 (5%)
Frame = +2
Query: 167 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 319
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 320 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 499
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 500 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 679
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 680 PVFDNMVAQG-LVQPVFSFY 736
MV +G L PVFS Y
Sbjct: 194 TAMQGMVQEGALTSPVFSVY 213
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 169 bits (411), Expect = 9e-42
Identities = 92/200 (46%), Positives = 124/200 (62%), Gaps = 10/200 (5%)
Frame = +2
Query: 167 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 319
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 320 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 499
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 500 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 679
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 680 PVFDNMVAQG-LVQPVFSFY 736
MV +G L PVFS Y
Sbjct: 194 TAMQGMVQEGALTSPVFSVY 213
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 169 bits (411), Expect = 9e-42
Identities = 92/200 (46%), Positives = 124/200 (62%), Gaps = 10/200 (5%)
Frame = +2
Query: 167 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 319
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 320 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 499
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 130
Query: 500 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 679
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 131 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 190
Query: 680 PVFDNMVAQG-LVQPVFSFY 736
MV +G L PVFS Y
Sbjct: 191 TAMQGMVQEGALTSPVFSVY 210
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 169 bits (411), Expect = 9e-42
Identities = 92/200 (46%), Positives = 124/200 (62%), Gaps = 10/200 (5%)
Frame = +2
Query: 167 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 319
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 320 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 499
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 500 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 679
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 680 PVFDNMVAQG-LVQPVFSFY 736
MV +G L PVFS Y
Sbjct: 194 TAMQGMVQEGALTSPVFSVY 213
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 169 bits (411), Expect = 9e-42
Identities = 92/200 (46%), Positives = 124/200 (62%), Gaps = 10/200 (5%)
Frame = +2
Query: 167 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 319
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 320 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 499
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 500 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 679
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 680 PVFDNMVAQG-LVQPVFSFY 736
MV +G L PVFS Y
Sbjct: 194 TAMQGMVQEGALTSPVFSVY 213
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 169 bits (411), Expect = 9e-42
Identities = 92/200 (46%), Positives = 124/200 (62%), Gaps = 10/200 (5%)
Frame = +2
Query: 167 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 319
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 320 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 499
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 500 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 679
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 680 PVFDNMVAQG-LVQPVFSFY 736
MV +G L PVFS Y
Sbjct: 194 TAMQGMVQEGALTSPVFSVY 213
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 168 bits (408), Expect = 2e-41
Identities = 95/215 (44%), Positives = 125/215 (58%), Gaps = 13/215 (6%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 280
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 281 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 454
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 455 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 634
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 635 ILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
ILG+A+ +I+ TPVFDN+ QGLV Q +FS Y
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVY 216
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 168 bits (408), Expect = 2e-41
Identities = 95/215 (44%), Positives = 125/215 (58%), Gaps = 13/215 (6%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 280
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 281 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 454
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 455 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 634
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 635 ILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
ILG+A+ +I+ TPVFDN+ QGLV Q +FS Y
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVY 216
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 166 bits (404), Expect = 6e-41
Identities = 94/215 (43%), Positives = 125/215 (58%), Gaps = 13/215 (6%)
Frame = +2
Query: 131 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 280
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
Query: 281 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 454
+PL NYLD +Y+G I IGTP Q F V+FDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 455 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 634
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 635 ILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFY 736
ILG+A+ +I+ TPVFDN+ QGLV Q +FS Y
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVY 216
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 126 bits (305), Expect = 6e-29
Identities = 58/121 (47%), Positives = 81/121 (66%), Gaps = 1/121 (0%)
Frame = +2
Query: 377 SNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 556
SN+WVPS KC AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 1 SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGG 60
Query: 557 LKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAQG-LVQPVFSF 733
+ V Q F E P L F+ A+FDG++GM F A+ VTP+FDN+++QG L + VFSF
Sbjct: 61 ITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF 119
Query: 734 Y 736
Y
Sbjct: 120 Y 120
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 66
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 67 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 126
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 127 KPSSSLETFFDSLVTQANIPNVFS 150
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 71.7 bits (168), Expect = 2e-12
Identities = 47/144 (32%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
+ FD++V Q + VFS
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFS 229
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 70.5 bits (165), Expect = 6e-12
Identities = 45/138 (32%), Positives = 71/138 (51%), Gaps = 4/138 (2%)
Frame = +2
Query: 329 IGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGS 508
IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G ++Y
Sbjct: 3 IGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQ 56
Query: 509 GSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA--VDHV 676
GS +GF+ D VT+ G + E G F+ +++GILG+A++T+A +
Sbjct: 57 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESGNFFLPGIQWNGILGLAYATLAKPSSSL 116
Query: 677 TPVFDNMVAQGLVQPVFS 730
FD++V Q + VFS
Sbjct: 117 ETFFDSLVTQANIPNVFS 134
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFS 212
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFS 212
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFS 212
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFS 212
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFS 212
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 115
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 116 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 175
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 176 RPDDSLEPFFDSLVKQTHVPNLFS 199
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFS 212
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 66.5 bits (155), Expect = 9e-11
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 159
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 160 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 219
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 220 RPDDSLEPFFDSLVKQTHVPNLFS 243
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 64.1 bits (149), Expect = 5e-10
Identities = 46/144 (31%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLFSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 665 --VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFS 212
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 60.1 bits (139), Expect = 8e-09
Identities = 38/82 (46%), Positives = 49/82 (59%), Gaps = 9/82 (10%)
Frame = +2
Query: 167 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 319
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 320 VISIGTPPQSFKVVFDTGSSNL 385
ISIGTPPQ+F V+FDTGSS L
Sbjct: 76 EISIGTPPQNFLVLFDTGSSPL 97
>AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 140
Score = 57.6 bits (133), Expect = 4e-08
Identities = 28/64 (43%), Positives = 39/64 (60%), Gaps = 1/64 (1%)
Frame = +2
Query: 548 VGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAQG-LVQPV 724
V ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T MV +G L PV
Sbjct: 71 VQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPV 130
Query: 725 FSFY 736
FS Y
Sbjct: 131 FSVY 134
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 56.4 bits (130), Expect = 1e-07
Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 56.4 bits (130), Expect = 1e-07
Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 55.2 bits (127), Expect = 2e-07
Identities = 39/130 (30%), Positives = 64/130 (49%), Gaps = 4/130 (3%)
Frame = +2
Query: 353 KVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLS 532
+++ DTGSSN V Y + +D+ +S TY + G ++Y GS +GF+
Sbjct: 3 QILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVG 56
Query: 533 TDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA--VDHVTPVFDNMV 700
D VT+ G + E F+ K++GILG+A++T+A + FD++V
Sbjct: 57 EDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLV 116
Query: 701 AQGLVQPVFS 730
Q + VFS
Sbjct: 117 TQANIPNVFS 126
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 42.3 bits (95), Expect = 0.002
Identities = 27/94 (28%), Positives = 42/94 (44%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAV 592
+ Y G G L TD + G + + +V
Sbjct: 129 YVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASV 162
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.002
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTD 538
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.002
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 490
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 491 AIQYGSGSLSGFLSTD 538
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant 1
protein.
Length = 396
Score = 40.3 bits (90), Expect = 0.007
Identities = 28/83 (33%), Positives = 45/83 (54%), Gaps = 4/83 (4%)
Frame = +2
Query: 494 IQYGSGSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA- 664
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 25 VPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR 84
Query: 665 -VDHVTPVFDNMVAQGLVQPVFS 730
D + P FD++V Q V +FS
Sbjct: 85 PDDSLEPFFDSLVKQTHVPNLFS 107
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 38.7 bits (86), Expect = 0.022
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Frame = +2
Query: 158 SVMALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 310
+V+ RVPL + K+ R E G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 311 YYGVISIGTP 340
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 36.7 bits (81), Expect = 0.087
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +2
Query: 311 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTY 469
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>M11437-2|AAB59550.1| 644|Homo sapiens kininogen protein.
Length = 644
Score = 33.1 bits (72), Expect = 1.1
Identities = 22/65 (33%), Positives = 27/65 (41%)
Frame = -3
Query: 730 REDGLHESLSHHVVEHRGHMVHCDSAEGHPEDPVELGGHEGKPGLRHGLGERLAPHLEPA 551
R D HE H + H GH D GH GHE + GL HG +L LE
Sbjct: 428 RHDWGHEKQRKHNLGH-GHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQ 486
Query: 550 HGDII 536
G ++
Sbjct: 487 GGHVL 491
>AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protein
LIP8 protein.
Length = 119
Score = 32.3 bits (70), Expect = 1.9
Identities = 13/33 (39%), Positives = 16/33 (48%)
Frame = -2
Query: 533 WRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCC 435
W GS+R C + V + S SW CR CC
Sbjct: 8 WPGSKRECANCRVGTSSWRSSGWSWWKDCRPCC 40
>AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens
cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (EC
2.7.7.6). ).
Length = 260
Score = 31.9 bits (69), Expect = 2.5
Identities = 17/35 (48%), Positives = 18/35 (51%)
Frame = -2
Query: 542 HHQWRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTC 438
H+ W GS R C S T S G HS SWT R C
Sbjct: 26 HNSWTGSNRACSSWTGSTRG-HS---SWTGSSRAC 56
>BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain
containing 11 protein.
Length = 514
Score = 30.7 bits (66), Expect = 5.7
Identities = 12/26 (46%), Positives = 18/26 (69%)
Frame = -3
Query: 376 GSGVEYHLERLRRRADTDHSVVLSIK 299
G G E+HLER+RR ++++ SIK
Sbjct: 30 GQGAEHHLERIRRSHQKHNAILASIK 55
>BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member 12
protein.
Length = 578
Score = 25.4 bits (53), Expect(2) = 7.2
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -2
Query: 302 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 150
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 7.2
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -2
Query: 449 CRTCCAANKRCWCSGTFWKAPRGWRIR 369
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ10260 fis, clone HEMBB1000973, moderately
similar to Mus musculus schlafen3 mRNA. ).
Length = 578
Score = 25.4 bits (53), Expect(2) = 7.2
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -2
Query: 302 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 150
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINASLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 7.2
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -2
Query: 449 CRTCCAANKRCWCSGTFWKAPRGWRIR 369
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 7.5
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -2
Query: 527 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 408
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 7.5
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -2
Query: 527 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 408
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated protein
protein.
Length = 129
Score = 30.3 bits (65), Expect = 7.5
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -2
Query: 527 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 408
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>X85133-1|CAA59445.1| 948|Homo sapiens RB protein binding protein
protein.
Length = 948
Score = 29.9 bits (64), Expect = 10.0
Identities = 16/46 (34%), Positives = 21/46 (45%)
Frame = -1
Query: 642 PRIPSNLAATKASPGSDTASANVWRRTLSPPTVTSSVERKPERLPE 505
P P+NL+ S G TA +N T +PP R+ RL E
Sbjct: 429 PPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKE 474
>AY072922-1|AAL68925.1| 1625|Homo sapiens p53-associated cellular
protein PACT protein.
Length = 1625
Score = 29.9 bits (64), Expect = 10.0
Identities = 16/46 (34%), Positives = 21/46 (45%)
Frame = -1
Query: 642 PRIPSNLAATKASPGSDTASANVWRRTLSPPTVTSSVERKPERLPE 505
P P+NL+ S G TA +N T +PP R+ RL E
Sbjct: 472 PPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKE 517
>AK096194-1|BAC04723.1| 138|Homo sapiens protein ( Homo sapiens
cDNA FLJ38875 fis, clone MESAN2013936. ).
Length = 138
Score = 29.9 bits (64), Expect = 10.0
Identities = 14/45 (31%), Positives = 19/45 (42%)
Frame = -2
Query: 512 CRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCSGTFWKAPRGW 378
C S T C R + C +CC + + C CS T+W W
Sbjct: 75 CLSEEAGETAC--RASPGQCYVTSCCLS-RHCTCSLTWWDVLLNW 116
>AF352051-1|AAL05625.1| 1616|Homo sapiens proliferation
potential-related protein protein.
Length = 1616
Score = 29.9 bits (64), Expect = 10.0
Identities = 16/46 (34%), Positives = 21/46 (45%)
Frame = -1
Query: 642 PRIPSNLAATKASPGSDTASANVWRRTLSPPTVTSSVERKPERLPE 505
P P+NL+ S G TA +N T +PP R+ RL E
Sbjct: 429 PPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKE 474
>AB126079-1|BAD20206.1| 202|Homo sapiens keratin associated protein
protein.
Length = 202
Score = 29.9 bits (64), Expect = 10.0
Identities = 18/66 (27%), Positives = 29/66 (43%)
Frame = -2
Query: 527 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCSGTFWKAPRGWRIRCRIPP*T 348
GS+ GC S S+ GC S S C+ CC ++ C + P + C +P
Sbjct: 119 GSKGGCGSCGGSKGGCGSCGCSQCNCCKPCCCSSGCGSCCQSSCCNPCCCQSSCCVPVCC 178
Query: 347 TAAACR 330
++ C+
Sbjct: 179 QSSCCK 184
>AB112075-1|BAC77637.1| 1758|Homo sapiens retinoblastoma binding
protein 6 isoform 2 protein.
Length = 1758
Score = 29.9 bits (64), Expect = 10.0
Identities = 16/46 (34%), Positives = 21/46 (45%)
Frame = -1
Query: 642 PRIPSNLAATKASPGSDTASANVWRRTLSPPTVTSSVERKPERLPE 505
P P+NL+ S G TA +N T +PP R+ RL E
Sbjct: 605 PPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKE 650
>AB112074-1|BAC77636.1| 1792|Homo sapiens retinoblastoma binding
protein 6 isoform 1 protein.
Length = 1792
Score = 29.9 bits (64), Expect = 10.0
Identities = 16/46 (34%), Positives = 21/46 (45%)
Frame = -1
Query: 642 PRIPSNLAATKASPGSDTASANVWRRTLSPPTVTSSVERKPERLPE 505
P P+NL+ S G TA +N T +PP R+ RL E
Sbjct: 605 PPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKE 650
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 112,413,702
Number of Sequences: 237096
Number of extensions: 2464236
Number of successful extensions: 7512
Number of sequences better than 10.0: 87
Number of HSP's better than 10.0 without gapping: 6741
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7430
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8791154398
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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