Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= NRPG0400
(723 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 272 6e-72
UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular organ... 266 5e-70
UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein; ... 252 5e-66
UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5; ... 250 2e-65
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 227 2e-58
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 186 6e-46
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 173 5e-42
UniRef50_Q9H302 Cluster: NADP+-specific isocitrate dehydrogenase... 128 2e-28
UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2; ... 96 9e-19
UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4; Eukaryot... 77 6e-13
UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3... 71 4e-11
UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase... 63 8e-09
UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase... 58 3e-07
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 56 9e-07
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 48 2e-04
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 41 0.036
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 41 0.036
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 39 0.11
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 38 0.33
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 37 0.44
UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30; ... 37 0.58
UniRef50_Q4RZN4 Cluster: Chromosome 18 SCAF14786, whole genome s... 36 1.3
UniRef50_A5BYB3 Cluster: Putative uncharacterized protein; n=2; ... 36 1.3
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 36 1.3
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 36 1.3
UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenas... 35 1.8
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 35 2.3
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 34 3.1
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 34 3.1
UniRef50_UPI00015B5E86 Cluster: PREDICTED: similar to regulator ... 34 4.1
UniRef50_UPI000023F064 Cluster: hypothetical protein FG07568.1; ... 34 4.1
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 34 4.1
UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2; N... 34 4.1
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 34 4.1
UniRef50_Q2Q0B6 Cluster: Putative 3-isopropylmalate dehydrogenas... 33 7.1
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 33 7.1
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 33 7.1
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 33 9.4
UniRef50_Q55ME2 Cluster: Putative uncharacterized protein; n=1; ... 33 9.4
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 272 bits (667), Expect = 6e-72
Identities = 124/180 (68%), Positives = 148/180 (82%), Gaps = 1/180 (0%)
Frame = +3
Query: 24 QEYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMT 203
+ YK F+ IWYEHRLIDDMVA +KS GGFVWACKNYDGDVQSD +AQG+GSLGLMT
Sbjct: 272 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMT 331
Query: 204 SVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDAL 383
SVL+CPDGKT+EAEAAHGTVTRH+R +Q+G+ TSTNPIASIFAWTRGL HR KLD N L
Sbjct: 332 SVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 391
Query: 384 KNFAETLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYY-ETFEFMDKLAENLKVALGQ 560
FA+ LEKVC+ET+ESG MTKDLA CI G++NVK ++++ T +F+D + NL ALG+
Sbjct: 392 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGR 451
>UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular
organisms|Rep: F12P19.10 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 410
Score = 266 bits (651), Expect = 5e-70
Identities = 123/175 (70%), Positives = 144/175 (82%)
Frame = +3
Query: 30 YKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSV 209
+K +++ AGIWYEHRLIDDMVAYA+KSEGG+VWACKNYDGDVQSD +AQG+GSLGLMTSV
Sbjct: 235 WKSKYDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSV 294
Query: 210 LICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKN 389
L+CPDGKT+EAEAAHGTVTRHFR +Q+G ETSTN IASIFAWTRGL HRAKLD+N L +
Sbjct: 295 LVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLD 354
Query: 390 FAETLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVAL 554
F E LE C+ T+ESG MTKDLA+ I G + + R Y T EF+D +A LK L
Sbjct: 355 FTEKLEAACVGTVESGKMTKDLALIIHG-SKLSRDTYLNTEEFIDAVAAELKERL 408
>UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein;
n=6; core eudicotyledons|Rep: Isocitrate
dehydrogenase-like protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 485
Score = 252 bits (618), Expect = 5e-66
Identities = 117/172 (68%), Positives = 141/172 (81%)
Frame = +3
Query: 30 YKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSV 209
+K++FE+ IWYEHRLIDDMVAYA+KSEGG+VWACKNYDGDVQSD +AQG+GSLGLMTSV
Sbjct: 306 WKQKFEEHSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSV 365
Query: 210 LICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKN 389
L+ DGKT+E+EAAHGTVTRHFR +Q+G+ETSTN IASIFAWTRGL HRAKLD N+ L +
Sbjct: 366 LLSADGKTLESEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDKNEKLMD 425
Query: 390 FAETLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLK 545
F + LE C+ T+E+G MTKDLA+ I G V R + T EF+D +A LK
Sbjct: 426 FVKKLESSCVNTVETGKMTKDLALLIHG-PKVSRDLFLNTEEFIDAVASKLK 476
>UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5;
Eukaryota|Rep: Putative uncharacterized protein - Oryza
sativa subsp. indica (Rice)
Length = 475
Score = 250 bits (613), Expect = 2e-65
Identities = 115/164 (70%), Positives = 136/164 (82%)
Frame = +3
Query: 63 YEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEA 242
YEHRLIDDMVAYA+KSEGG+VWACKNYDGDVQSD +AQG+GSLGLMTSVL+CPDG+T+EA
Sbjct: 307 YEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDLIAQGFGSLGLMTSVLVCPDGRTIEA 366
Query: 243 EAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIE 422
EAAHGTVTRH+R +Q+G ETSTN IASIFAWT GL HRAKLD+N L +F + LE C+
Sbjct: 367 EAAHGTVTRHYRVHQKGGETSTNSIASIFAWTTGLGHRAKLDDNKRLLDFVQKLEAACVG 426
Query: 423 TIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVAL 554
T+ESG MTKDLA+ + G NV R Y T EF+D +AE+L+ L
Sbjct: 427 TVESGKMTKDLALLVHG-PNVSRDKYLNTVEFIDAVAEDLRTRL 469
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 227 bits (556), Expect = 2e-58
Identities = 111/177 (62%), Positives = 131/177 (74%), Gaps = 1/177 (0%)
Frame = +3
Query: 27 EYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTS 206
EYKK+F+ GIWYEHRLIDDMVA +KSEGGF+ A KNYDGDVQSD VAQG+GSLGLMTS
Sbjct: 289 EYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGFIMALKNYDGDVQSDIVAQGFGSLGLMTS 348
Query: 207 VLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALK 386
L PDG E+EAAHGTVTRH+R +Q+G+ETSTNPIASIFAWTRGL+ R +LDN +
Sbjct: 349 TLTTPDGSAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLVQRGQLDNTPDVV 408
Query: 387 NFAETLEKVCIETI-ESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVAL 554
FAE LE+ CIE + E GIMTKDLA+ +R + T E+M + LK L
Sbjct: 409 TFAEELERACIEVVNEEGIMTKDLAL---SCGRKEREAWVTTREYMAAVERRLKANL 462
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 186 bits (452), Expect = 6e-46
Identities = 87/145 (60%), Positives = 109/145 (75%)
Frame = +3
Query: 27 EYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTS 206
E+K +FE+AG+ Y + LIDD+VA MK+EGGF+WACKNYDGDV SD V+ +GSL +MTS
Sbjct: 247 EFKDRFEEAGLTYFYSLIDDIVARVMKAEGGFIWACKNYDGDVMSDMVSSAFGSLAMMTS 306
Query: 207 VLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALK 386
VL+ P G E EAAHGTV RH+ + +GKETSTN +A+IFAWT L R +LD N L+
Sbjct: 307 VLVSPQG-YYEYEAAHGTVQRHYYRHLEGKETSTNSVATIFAWTGALRKRGELDGNQKLE 365
Query: 387 NFAETLEKVCIETIESGIMTKDLAI 461
FA+ LEK + TIESG MTKDLA+
Sbjct: 366 EFADKLEKATLSTIESGKMTKDLAL 390
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 173 bits (420), Expect = 5e-42
Identities = 87/173 (50%), Positives = 116/173 (67%)
Frame = +3
Query: 27 EYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTS 206
EY +F DAGI Y + LIDD VA +KSEGGF+WACKNYDGDV SD VA +GSL +MTS
Sbjct: 233 EYDAKFNDAGIEYFYTLIDDAVARVVKSEGGFIWACKNYDGDVMSDMVATAFGSLAMMTS 292
Query: 207 VLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALK 386
VL+ P+G E EAAHGTV +H+ + +G+ TSTN +A++FAWT L R ++D + L
Sbjct: 293 VLVSPEG-YYEYEAAHGTVQKHYYQHLKGQLTSTNSMATLFAWTGALRKRGEIDGINELV 351
Query: 387 NFAETLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLK 545
FA+ LE I TIE GIMTKDLA ++ ++ T EF+ ++ + L+
Sbjct: 352 EFADRLENTSIRTIEEGIMTKDLA----SLSELENKKIVNTEEFLLEIKKRLE 400
>UniRef50_Q9H302 Cluster: NADP+-specific isocitrate dehydrogenase;
n=1; Homo sapiens|Rep: NADP+-specific isocitrate
dehydrogenase - Homo sapiens (Human)
Length = 127
Score = 128 bits (308), Expect = 2e-28
Identities = 61/89 (68%), Positives = 69/89 (77%)
Frame = +3
Query: 294 KETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIETIESGIMTKDLAICIKG 473
+E STNPIASIFAWTRGL RAK DNN L FA LE+VCIETIE+G MTKDLA CIKG
Sbjct: 1 QEISTNPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKG 60
Query: 474 MNNVKRSDYYETFEFMDKLAENLKVALGQ 560
+ + + SDY TFEFM+KL ENLK+ L Q
Sbjct: 61 LPSAQCSDYLNTFEFMEKLGENLKIKLAQ 89
>UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 371
Score = 95.9 bits (228), Expect = 9e-19
Identities = 39/51 (76%), Positives = 48/51 (94%)
Frame = +3
Query: 24 QEYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQ 176
+++K++FE+ IWYEHRLIDDMVAYA+KSEGG+VWACKNYDGDVQSD +AQ
Sbjct: 107 EKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDFLAQ 157
>UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4;
Eukaryota|Rep: Isocitrate dehydrogenase - Saltugilia
latimeri
Length = 158
Score = 76.6 bits (180), Expect = 6e-13
Identities = 41/110 (37%), Positives = 49/110 (44%)
Frame = +3
Query: 24 QEYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMT 203
+ +K ++E AGIWYEHRLIDDM
Sbjct: 49 KSWKSKYEAAGIWYEHRLIDDMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 108
Query: 204 SVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLH 353
AAHG VTRH+R +Q+G E STN IASIFAW+RGL H
Sbjct: 109 XXXXXXXXXXXXXXAAHGAVTRHYRVHQKGGEASTNSIASIFAWSRGLAH 158
>UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3;
Ostreococcus|Rep: COG0538: Isocitrate dehydrogenases -
Ostreococcus tauri
Length = 429
Score = 70.5 bits (165), Expect = 4e-11
Identities = 53/155 (34%), Positives = 75/155 (48%), Gaps = 11/155 (7%)
Frame = +3
Query: 24 QEYKKQFEDAGIWYE-----HRLIDDMVAYAMK-SEGGFVWACKNYDGDVQSDSVAQGYG 185
+E+K QF AG+ E H L D ++ +GGF A NYDGDV +D +AQ +
Sbjct: 254 EEFKAQFVAAGVMKEGEELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQVHK 313
Query: 186 SLGLMTSVL--ICPDGKTV-EAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHR 356
S G +TS L + DG + E EA+HGTV +G+ETS NP+ + + H
Sbjct: 314 SPGFITSNLVGVHEDGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHA 373
Query: 357 AKLDN--NDALKNFAETLEKVCIETIESGIMTKDL 455
A + N D F + V + G T+DL
Sbjct: 374 ADVHNIDRDRTHAFTTKMRTVIHQLFREGKGTRDL 408
>UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=2; Rhodobacteraceae|Rep: NADP-dependent
isocitrate dehydrogenase protein - Sagittula stellata
E-37
Length = 459
Score = 62.9 bits (146), Expect = 8e-09
Identities = 41/139 (29%), Positives = 71/139 (51%)
Frame = -2
Query: 455 KVFSHNSRFNSFNADLLQSLSKVL*GIIVV*FSTMQQTSSPSKN*SNWIGGCLFSLLIES 276
+V H + + + LQ L KVL + V + Q + P + + +GG +LL+ +
Sbjct: 80 QVLGHVAGLHGLDDHPLQRLGKVLQRRVAVQLRAVLQPAGPGIDRRDGVGGGRLALLVLT 139
Query: 275 EMTCNSAMGSFSLNCFAIRTNENRCHEAQ*PIALSNTIRLYVSIIIFAGPDKSTL*FXXX 96
M + A+ L+ AIR ++ R H Q P AL + +RL+V++I+ AGPD+ +
Sbjct: 140 VMARHRAVRRLRLHDPAIRRHQLRGHHPQRPEALRHRVRLHVAVIVLAGPDELAVPLERA 199
Query: 95 XXXXIN*PVFIPDTSILKL 39
++ PV +PD L+L
Sbjct: 200 GHHVVDQPVLVPDALRLEL 218
>UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: NADP-dependent
isocitrate dehydrogenase protein - Rhizobium etli
(strain CFN 42 / ATCC 51251)
Length = 437
Score = 57.6 bits (133), Expect = 3e-07
Identities = 39/145 (26%), Positives = 70/145 (48%)
Frame = -2
Query: 467 DANGKVFSHNSRFNSFNADLLQSLSKVL*GIIVV*FSTMQQTSSPSKN*SNWIGGCLFSL 288
D +V H + FN +ADL Q ++ IVV + +T+ P ++ N + +L
Sbjct: 45 DEQRQVLGHEAGFNGVDADLFQRRGELGKFGIVVELGAVGETTGPGEDRCNRVRRGFLTL 104
Query: 287 LIESEMTCNSAMGSFSLNCFAIRTNENRCHEAQ*PIALSNTIRLYVSIIIFAGPDKSTL* 108
L+ + + + M F + AI +NR H+ + AL + I L V++++ AGPD ++
Sbjct: 105 LMLTIVAGHRTMSGFGFDRLAIGRQQNRGHQPERAEALRDGIGLDVAVVVLAGPDVASGP 164
Query: 107 FXXXXXXXIN*PVFIPDTSILKLFL 33
++ VF+ D L+L L
Sbjct: 165 LQGRGDHVVDQTVFVGDPGFLELIL 189
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 56.0 bits (129), Expect = 9e-07
Identities = 37/113 (32%), Positives = 58/113 (51%), Gaps = 2/113 (1%)
Frame = +3
Query: 123 VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEAEAAHGTVTRHFRFYQQ--GK 296
++ +N DGD+ SD A GSL +S+ I T+ EA HGT + Y + GK
Sbjct: 440 LYPAQNLDGDIFSDISAALGGSLATASSI-IESKSSTMLFEAPHGTAHDLYLKYLESNGK 498
Query: 297 ETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIETIESGIMTKDL 455
+ NP A I+A L + + N+AL +++ L+ +T+ GI+T DL
Sbjct: 499 DAHFNPSALIYALANALETLGRRERNEALLDYSARLKAALKDTVGDGIVTADL 551
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 48.0 bits (109), Expect = 2e-04
Identities = 45/138 (32%), Positives = 65/138 (47%), Gaps = 7/138 (5%)
Frame = +3
Query: 63 YEHRLIDDMVAYAM---KSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPD--- 224
Y+ +LID AYA+ ++ V C N DGD+ SD V YGS+ S+LI D
Sbjct: 206 YDPQLID--AAYALLIARATRPLVIPCLNRDGDILSDLVLALYGSIAGSESLLIAFDEQF 263
Query: 225 -GKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 401
+ V AEA HGT QGK + NP+A A G L + D +
Sbjct: 264 NPRVVMAEAPHGTAPS-----LQGKNLA-NPLAMQLA--AGALLKQMPD--PEYQRAGAA 313
Query: 402 LEKVCIETIESGIMTKDL 455
+++ C++ + G+ T DL
Sbjct: 314 IQEACLQAVAQGVRTADL 331
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 40.7 bits (91), Expect = 0.036
Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 1/151 (0%)
Frame = +3
Query: 6 LSRYL*QEYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGY 182
L R + +E F D + EH ID+ ++ F V C N GD+ SD +A
Sbjct: 202 LWRQVVEEVAVDFPDVEL--EHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLT 259
Query: 183 GSLGLMTSVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAK 362
GS+GL++S + G + E A G+ GK + NPIA I + L+ R
Sbjct: 260 GSMGLLSSASMNSTGFGL-FEPAGGSAPD-----IAGKGIA-NPIAQIL--SAALMLRHS 310
Query: 363 LDNNDALKNFAETLEKVCIETIESGIMTKDL 455
L +A A +E+ + + SG +T +L
Sbjct: 311 LKQEEA----ASAIERAVTKALNSGYLTGEL 337
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 40.7 bits (91), Expect = 0.036
Identities = 40/135 (29%), Positives = 58/135 (42%), Gaps = 1/135 (0%)
Frame = +3
Query: 57 IWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKT 233
+ Y+ L+D M + + F V N GD+ +D + GSLG++ S + DG
Sbjct: 215 VQYDVVLVDSMAMHLINRPSEFDVVVTGNMFGDILTDEASMLPGSLGMLPSASL-GDGGP 273
Query: 234 VEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKV 413
E HG+ GK + NP+A+I A L H L + AE +EK
Sbjct: 274 GLYEPIHGSAPDI-----AGKSVA-NPLATILAAAMMLRHSLGLTDE------AEAIEKA 321
Query: 414 CIETIESGIMTKDLA 458
I G+ T DLA
Sbjct: 322 VAGVITDGLRTPDLA 336
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 39.1 bits (87), Expect = 0.11
Identities = 36/136 (26%), Positives = 63/136 (46%), Gaps = 1/136 (0%)
Frame = +3
Query: 51 AGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDG 227
AG+ + L+D M+A+ +++ F V N GD+ SD A+ GSLGL S+ +
Sbjct: 218 AGLEVDDILVDAMMAHVVRNPDRFDVIVATNMFGDILSDLTAELSGSLGLGGSLNV--GD 275
Query: 228 KTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLE 407
+ A+AAHG+ G++ + NP++ I + L + + A +E
Sbjct: 276 RYAMAQAAHGSAPD-----IAGQDVA-NPVSLILSTALLLAWHGERSGAVRYEEAARAIE 329
Query: 408 KVCIETIESGIMTKDL 455
+ I G T+D+
Sbjct: 330 AAVAKAIGEGRATRDV 345
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 37.5 bits (83), Expect = 0.33
Identities = 27/69 (39%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Frame = +3
Query: 57 IWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKT 233
I+YE +ID+ +K+ F V N GD+ SD A G LGL S+ I DG
Sbjct: 237 IYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIA 296
Query: 234 VEAEAAHGT 260
+ AEA HG+
Sbjct: 297 L-AEAVHGS 304
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 37.1 bits (82), Expect = 0.44
Identities = 44/163 (26%), Positives = 73/163 (44%), Gaps = 1/163 (0%)
Frame = +3
Query: 6 LSRYL*QEYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGY 182
L R + +E K++ D + EH+L+D + + F V +N GD+ SD +
Sbjct: 192 LWRQIAEEVAKEYSDVTL--EHQLVDSAAMVMITNPACFDVVVTENLFGDILSDESSVLP 249
Query: 183 GSLGLMTSVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAK 362
G+LG+M S G ++ E HG+ GK + NPI+ I + ++ R
Sbjct: 250 GTLGVMPSASHSESGPSL-YEPIHGSAPD-----IAGKGIA-NPISMIL--SVAMMLRDS 300
Query: 363 LDNNDALKNFAETLEKVCIETIESGIMTKDLAICIKGMNNVKR 491
AE +E +T+ GI+T+DL G+ N K+
Sbjct: 301 FGETAG----AEMIEHAVNKTLTQGILTRDLG----GLANTKQ 335
>UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 382
Score = 36.7 bits (81), Expect = 0.58
Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 2/132 (1%)
Frame = +3
Query: 66 EHRLIDD--MVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVE 239
+H+LID M+ ++ + N GD+ SD + GSLGL+ S + +
Sbjct: 235 QHQLIDSAAMILVQSPTKLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLA---SLPD 291
Query: 240 AEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCI 419
+A G E NP+A+I + ++ R LD AE LEK
Sbjct: 292 TNSAFGLYEPCHGSAPDLTENKVNPVATILSVA--MMLRLSLDCVPE----AEALEKAVG 345
Query: 420 ETIESGIMTKDL 455
+ ++SGI T DL
Sbjct: 346 QVLDSGIRTGDL 357
>UniRef50_Q4RZN4 Cluster: Chromosome 18 SCAF14786, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 18
SCAF14786, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1004
Score = 35.5 bits (78), Expect = 1.3
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Frame = -1
Query: 168 HYQIVRLHHNFCRPRQIHPLIS*HKP--PYHQLACVHTRYQHPQTVSCTPVI 19
H+ +RLH FCRP +IH LI P P +L C+ + + +SC P++
Sbjct: 589 HHSYLRLHF-FCRPPRIHLLIPVPPPGSPESELICLVSPHPPRSPMSCLPLL 639
>UniRef50_A5BYB3 Cluster: Putative uncharacterized protein; n=2;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 423
Score = 35.5 bits (78), Expect = 1.3
Identities = 17/30 (56%), Positives = 20/30 (66%)
Frame = +3
Query: 222 DGKTVEAEAAHGTVTRHFRFYQQGKETSTN 311
DG T+E E A TV +H YQ+G ETSTN
Sbjct: 156 DGMTLEVETAFVTVPQHSWQYQKGLETSTN 185
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 35.5 bits (78), Expect = 1.3
Identities = 40/156 (25%), Positives = 71/156 (45%), Gaps = 2/156 (1%)
Frame = +3
Query: 72 RLIDDMVAYAM-KSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEAEA 248
R+ D+M+ + +++ V A N +GD SD+ G LG+ + G+ + AE
Sbjct: 323 RIADNMLQQLLTRTDEYSVIATMNLNGDYMSDAAGAQIGGLGIAPGI-NRGHGRCL-AEP 380
Query: 249 AHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIETI 428
HG+ ++ + NP A I + L + D D +++ E ETI
Sbjct: 381 VHGSAPKY------AGQDKVNPTAMILSGREMLDYLGWSDAADLVRDAVE-------ETI 427
Query: 429 ESGIMTKDLAICIKGMNNVKRSDYYE-TFEFMDKLA 533
SG +T DL I+G + S++ + + +D+LA
Sbjct: 428 SSGQVTYDLHRQIEGGEKLATSEFADAVVDKIDELA 463
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 35.5 bits (78), Expect = 1.3
Identities = 36/144 (25%), Positives = 61/144 (42%), Gaps = 1/144 (0%)
Frame = +3
Query: 30 YKKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTS 206
++ +F D + H +D+ +++ F V N GD+ SD A GSLG++ S
Sbjct: 215 HEAEFSDVEL--THLYVDNAAMQIVRAPSQFDVMVTCNIFGDILSDCAAMASGSLGMLPS 272
Query: 207 VLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALK 386
V + P + +A + V H + NP+ SI + ++ R L +
Sbjct: 273 VSLGPPDRLGRRKALYEPV--HGSAPDIAGKGIANPLGSIL--SVAMMLRITLHRPED-- 326
Query: 387 NFAETLEKVCIETIESGIMTKDLA 458
A LEK + +G T D+A
Sbjct: 327 --AALLEKAVDTALAAGARTADIA 348
>UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=2; Desulfitobacterium hafniense|Rep:
Isocitrate/isopropylmalate dehydrogenase -
Desulfitobacterium hafniense (strain DCB-2)
Length = 374
Score = 35.1 bits (77), Expect = 1.8
Identities = 44/147 (29%), Positives = 63/147 (42%), Gaps = 4/147 (2%)
Frame = +3
Query: 27 EYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMT 203
E + D G+ + +D + + +K F V AC+N GD+ D A G +G+
Sbjct: 212 EVSAGYPDIGLQFTQ--VDALAEHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITP 269
Query: 204 SVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLL--HRAKLDNND 377
+ + G T + HGT R GK + NP+ASI T GLL +D
Sbjct: 270 TADV--GGVTPQFRPNHGTFPR-----AVGKGFA-NPLASIL--TAGLLLDTLGNERGDD 319
Query: 378 ALKNFAETLEK-VCIETIESGIMTKDL 455
L+ A +EK V G TKDL
Sbjct: 320 NLRRGARLIEKAVEYNLTTGGPRTKDL 346
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 34.7 bits (76), Expect = 2.3
Identities = 40/142 (28%), Positives = 57/142 (40%), Gaps = 1/142 (0%)
Frame = +3
Query: 33 KKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSV 209
++ + D I EH +D M A+ ++ F V +N GD+ SD + GSLG T+
Sbjct: 214 QRDYPDVRIDDEH--VDAMTAHLVRRGRDFDVVVTENMFGDILSDLTGELSGSLG--TAP 269
Query: 210 LICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKN 389
I V A+AAHG + A + W L + D N L
Sbjct: 270 SINSSETKVMAQAAHGAAPDIAGHNRANPTALMLSAAMMLEW----LGDRRADRN--LGG 323
Query: 390 FAETLEKVCIETIESGIMTKDL 455
A + TI SG+ T DL
Sbjct: 324 AAHRIRDAVRATIASGVATADL 345
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 34.3 bits (75), Expect = 3.1
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 1/69 (1%)
Frame = +3
Query: 57 IWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKT 233
I Y +++D MV + F V N GD+ SD A GSLG++ S + P+
Sbjct: 235 IKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE--I 292
Query: 234 VEAEAAHGT 260
V E HG+
Sbjct: 293 VIGEPCHGS 301
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 34.3 bits (75), Expect = 3.1
Identities = 34/106 (32%), Positives = 43/106 (40%)
Frame = +3
Query: 138 NYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPI 317
N GD+ SD A G LGL S I K E HG+ Q + NP
Sbjct: 220 NLFGDILSDEAAGLIGGLGLAPSANI--GEKNALFEPVHGSAP------QIAGKNIANPT 271
Query: 318 ASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIETIESGIMTKDL 455
A I T L H K K A+ +EK +T+ G++T DL
Sbjct: 272 AMILTTTLMLKHLNK-------KQEAQKIEKALQKTLAEGLVTPDL 310
>UniRef50_UPI00015B5E86 Cluster: PREDICTED: similar to regulator of
telomere elongation helicase 1 rtel1; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to regulator of
telomere elongation helicase 1 rtel1 - Nasonia
vitripennis
Length = 1050
Score = 33.9 bits (74), Expect = 4.1
Identities = 20/64 (31%), Positives = 33/64 (51%)
Frame = +3
Query: 360 KLDNNDALKNFAETLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAEN 539
+L NN L + A +EK+C + I + D+A+CI + +V + ET + D L+E
Sbjct: 250 ELQNNVVLLDEAHNVEKMCEDAASLQISSTDIAVCIDEITHVMKDMANETND-QDFLSEG 308
Query: 540 LKVA 551
A
Sbjct: 309 SNAA 312
>UniRef50_UPI000023F064 Cluster: hypothetical protein FG07568.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG07568.1 - Gibberella zeae PH-1
Length = 379
Score = 33.9 bits (74), Expect = 4.1
Identities = 18/46 (39%), Positives = 27/46 (58%)
Frame = +3
Query: 399 TLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAE 536
T E + E G+ KD+ +C +G NV R+DYY+T E ++ AE
Sbjct: 96 TSEPYLLRDDEIGLNIKDI-MCSEGTGNV-RNDYYDTIEILEPRAE 139
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 33.9 bits (74), Expect = 4.1
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 4/124 (3%)
Frame = +3
Query: 78 IDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEA--EA 248
ID +VAY ++ F V N GD+ SD + G LGL S + P+ KT + E
Sbjct: 220 IDALVAYFVERPQEFEVVVASNLFGDILSDLGSAIVGGLGLSPSANLNPE-KTFPSMFEP 278
Query: 249 AHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLD-NNDALKNFAETLEKVCIET 425
HG+ GK + NPIA I++ L H+ + D + ++ ++ LE+ ++T
Sbjct: 279 VHGSAPD-----IAGKGIA-NPIAQIWSLALLLGHQGRKDLEHLIVQAISKVLEEGVVKT 332
Query: 426 IESG 437
+ G
Sbjct: 333 ADIG 336
>UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Nostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Nodularia spumigena CCY 9414
Length = 422
Score = 33.9 bits (74), Expect = 4.1
Identities = 28/80 (35%), Positives = 38/80 (47%), Gaps = 1/80 (1%)
Frame = +3
Query: 24 QEYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLM 200
QE QF D + E L+D++ + + F V N GD+ SD GSLGL+
Sbjct: 256 QEEAAQFPDVIV--EPMLVDNLAMQMVMNPQRFDVILASNLFGDILSDIGGALVGSLGLL 313
Query: 201 TSVLICPDGKTVEAEAAHGT 260
S + DG + EA HGT
Sbjct: 314 GSASLNADGFGL-YEAIHGT 332
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 33.9 bits (74), Expect = 4.1
Identities = 41/131 (31%), Positives = 57/131 (43%), Gaps = 1/131 (0%)
Frame = +3
Query: 66 EHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEA 242
+H +D M ++S F V N GD+ +D A+ G LGL S I P G ++
Sbjct: 212 DHYYVDAMAMKMIRSPEIFEVVVTPNMFGDILTDLGAEIVGGLGLAASGNINPRGVSM-F 270
Query: 243 EAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIE 422
E HG+ GK + NP+A+I L H LD A +EK +
Sbjct: 271 EPVHGSAPD-----IAGKGIA-NPLAAILTAALMLEHLG-LDRE------ASLVEKAVAK 317
Query: 423 TIESGIMTKDL 455
TIE +T DL
Sbjct: 318 TIEENKVTPDL 328
>UniRef50_Q2Q0B6 Cluster: Putative 3-isopropylmalate dehydrogenase;
n=1; uncultured organism HF10_3D09|Rep: Putative
3-isopropylmalate dehydrogenase - uncultured organism
HF10_3D09
Length = 175
Score = 33.1 bits (72), Expect = 7.1
Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Frame = +3
Query: 138 NYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPI 317
N GD+ +D + G +G+ S I D E HG+ +H + NPI
Sbjct: 53 NMFGDIATDLASVLQGGMGMAASGNIGDDHAFFEP--VHGSAPKH------AGQNKVNPI 104
Query: 318 ASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIETIESG-IMTKDL 455
ASI + L A+ N+D L + ++ L++ E ++ G +T DL
Sbjct: 105 ASINSVQMMLDWLARRSNDDDLLSVSKILDQSVAEHLKDGSSLTYDL 151
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 33.1 bits (72), Expect = 7.1
Identities = 41/136 (30%), Positives = 54/136 (39%), Gaps = 1/136 (0%)
Frame = +3
Query: 51 AGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDG 227
+ I +H LID A + S F V N GD+ SD A+ GS+GL S I D
Sbjct: 198 SNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAKISGSIGLAGSANIGKD- 256
Query: 228 KTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLE 407
EA HG+ + NP + A L+H L A +E
Sbjct: 257 -YAMFEAVHGSAP------DIAGQNIANPSGLLNAAIMMLVHL-------GLTEHAAKIE 302
Query: 408 KVCIETIESGIMTKDL 455
+TIE GI T D+
Sbjct: 303 NALKKTIEDGIHTADI 318
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 33.1 bits (72), Expect = 7.1
Identities = 48/174 (27%), Positives = 73/174 (41%), Gaps = 1/174 (0%)
Frame = +3
Query: 27 EYKKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMT 203
+Y + + I + R+ D+M + + V A N +GD SD+ A G LG+
Sbjct: 259 KYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAP 318
Query: 204 SVLICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDAL 383
I DG V E HG+ ++ + NP A I G L + DA
Sbjct: 319 GSNI-GDGIGV-FEPVHGSAPKY------AGQNKVNPTAEILT---GALMFEYIGWKDA- 366
Query: 384 KNFAETLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLK 545
+E ++K TI SGI+T D+ + M K T EF + + ENL+
Sbjct: 367 ---SEMIKKAVEMTISSGIVTYDIH---RHMGGTK----VGTREFAEAVVENLQ 410
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 32.7 bits (71), Expect = 9.4
Identities = 43/173 (24%), Positives = 67/173 (38%), Gaps = 1/173 (0%)
Frame = +3
Query: 33 KKQFEDAGIWYEHRLIDDMVAYAMKSEGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSV 209
K+ E G+ + +D ++ F V N GD+ SD AQ GSLGL
Sbjct: 190 KEVLEAEGVEVDEMYVDAAAMELVRRPERFDVMLTPNVFGDILSDLAAQVVGSLGL---- 245
Query: 210 LICPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKN 389
P G E A V H + + NP A++ A + L +
Sbjct: 246 --APSGNIGEERALFEPV--HGAAFDIAGKGIANPTATMLAASMMLEWLERKKGLPKGAE 301
Query: 390 FAETLEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKV 548
A L++ + + G+ T DL G N Y TFEF +++ + L++
Sbjct: 302 AAAALQRAIEKALSEGVKTPDL-----GGN-------YGTFEFAEEVVKRLQL 342
>UniRef50_Q55ME2 Cluster: Putative uncharacterized protein; n=1;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 529
Score = 32.7 bits (71), Expect = 9.4
Identities = 15/36 (41%), Positives = 21/36 (58%)
Frame = +3
Query: 117 GFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPD 224
G ACKN DGD + ++ +G S + TS L+ PD
Sbjct: 52 GTTMACKNEDGDEEEEADVEGILSPTMDTSTLLSPD 87
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 666,780,022
Number of Sequences: 1657284
Number of extensions: 12945107
Number of successful extensions: 28911
Number of sequences better than 10.0: 39
Number of HSP's better than 10.0 without gapping: 27921
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 28887
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 58677691418
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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