Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP27_F_L05
(954 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U40380-1|AAB05895.1| 374|Homo sapiens presenilin I-374 protein. 51 7e-06
U40379-1|AAB05894.1| 463|Homo sapiens presenilin I-463 protein. 51 7e-06
L76517-1|AAB46370.1| 463|Homo sapiens presenilin 1 protein. 51 7e-06
BC011729-1|AAH11729.1| 463|Homo sapiens PSEN1 protein protein. 51 7e-06
AK223173-1|BAD96893.1| 463|Homo sapiens presenilin 1 isoform I-... 51 7e-06
U50871-1|AAB50054.1| 448|Homo sapiens familial Alzheimer's dise... 50 1e-05
U34349-1|AAC50290.1| 442|Homo sapiens seven trans-membrane doma... 50 1e-05
L76528-1|AAB46371.1| 467|Homo sapiens presenilin 1 protein. 50 1e-05
L44577-1|AAC42012.1| 448|Homo sapiens E5-1 protein protein. 50 1e-05
L43964-1|AAB59557.1| 448|Homo sapiens STM-2 protein. 50 1e-05
L42110-1|AAB46416.1| 467|Homo sapiens S182 protein. 50 1e-05
D84149-1|BAA20883.1| 113|Homo sapiens presenilin 1 protein. 50 1e-05
BT006984-1|AAP35630.1| 448|Homo sapiens presenilin 2 (Alzheimer... 50 1e-05
BC006365-1|AAH06365.1| 448|Homo sapiens PSEN2 protein protein. 50 1e-05
AL391628-2|CAH73111.1| 481|Homo sapiens presenilin 2 (Alzheimer... 50 1e-05
AL391628-1|CAH73110.1| 448|Homo sapiens presenilin 2 (Alzheimer... 50 1e-05
AJ008005-1|CAA07825.1| 184|Homo sapiens minilin protein. 50 1e-05
AF416718-1|AAL16812.1| 390|Homo sapiens presenilin 2 transcript... 50 1e-05
AF416717-1|AAL16811.1| 378|Homo sapiens presenilin 1 protein. 50 1e-05
AF109907-2|AAC97960.1| 467|Homo sapiens PS1 protein. 50 1e-05
AC004858-2|AAF19254.1| 184|Homo sapiens minilin (short form of ... 50 1e-05
AC004858-1|AAF19253.1| 289|Homo sapiens presenilin 1 protein. 50 1e-05
U04520-2|AAC27816.1| 1685|Homo sapiens type IV collagen alpha 5 ... 31 4.7
U04520-1|AAF66217.2| 1691|Homo sapiens type IV collagen alpha 5 ... 31 4.7
M90464-1|AAA52046.1| 910|Homo sapiens alpha-5 type IV collagen ... 31 4.7
M58526-1|AAA99480.1| 1604|Homo sapiens alpha-5 type IV collagen ... 31 4.7
BC035387-1|AAH35387.1| 695|Homo sapiens COL4A5 protein protein. 31 4.7
AL035425-1|CAB90289.2| 1685|Homo sapiens collagen type IV alpha ... 31 4.7
AL034369-4|CAA22267.2| 1685|Homo sapiens collagen type IV alpha ... 31 4.7
AL031622-1|CAI43038.1| 1685|Homo sapiens collagen type IV alpha ... 31 4.7
>U40380-1|AAB05895.1| 374|Homo sapiens presenilin I-374 protein.
Length = 374
Score = 50.8 bits (116), Expect = 7e-06
Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 1/95 (1%)
Frame = +3
Query: 261 AEARPDRELAXRIARKLLTKSDNQRSYGXVXQIEGG-PSGASIAXQPRVXXXXXXXQIXE 437
A+ D L+ + + +++RS G + G P G S R + E
Sbjct: 14 AQMSEDNHLSNTNDNRERQEHNDRRSLGHPEPLSNGRPQGNS-----RQVVEQDEEEDEE 68
Query: 438 LELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
L L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 69 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 103
>U40379-1|AAB05894.1| 463|Homo sapiens presenilin I-463 protein.
Length = 463
Score = 50.8 bits (116), Expect = 7e-06
Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 1/95 (1%)
Frame = +3
Query: 261 AEARPDRELAXRIARKLLTKSDNQRSYGXVXQIEGG-PSGASIAXQPRVXXXXXXXQIXE 437
A+ D L+ + + +++RS G + G P G S R + E
Sbjct: 14 AQMSEDNHLSNTNDNRERQEHNDRRSLGHPEPLSNGRPQGNS-----RQVVEQDEEEDEE 68
Query: 438 LELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
L L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 69 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 103
>L76517-1|AAB46370.1| 463|Homo sapiens presenilin 1 protein.
Length = 463
Score = 50.8 bits (116), Expect = 7e-06
Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 1/95 (1%)
Frame = +3
Query: 261 AEARPDRELAXRIARKLLTKSDNQRSYGXVXQIEGG-PSGASIAXQPRVXXXXXXXQIXE 437
A+ D L+ + + +++RS G + G P G S R + E
Sbjct: 14 AQMSEDNHLSNTNDNRERQEHNDRRSLGHPEPLSNGRPQGNS-----RQVVEQDEEEDEE 68
Query: 438 LELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
L L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 69 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 103
>BC011729-1|AAH11729.1| 463|Homo sapiens PSEN1 protein protein.
Length = 463
Score = 50.8 bits (116), Expect = 7e-06
Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 1/95 (1%)
Frame = +3
Query: 261 AEARPDRELAXRIARKLLTKSDNQRSYGXVXQIEGG-PSGASIAXQPRVXXXXXXXQIXE 437
A+ D L+ + + +++RS G + G P G S R + E
Sbjct: 14 AQMSEDNHLSNTNDNRERQEHNDRRSLGHPEPLSNGRPQGNS-----RQVVEQDEEEDEE 68
Query: 438 LELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
L L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 69 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 103
>AK223173-1|BAD96893.1| 463|Homo sapiens presenilin 1 isoform I-463
variant protein.
Length = 463
Score = 50.8 bits (116), Expect = 7e-06
Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 1/95 (1%)
Frame = +3
Query: 261 AEARPDRELAXRIARKLLTKSDNQRSYGXVXQIEGG-PSGASIAXQPRVXXXXXXXQIXE 437
A+ D L+ + + +++RS G + G P G S R + E
Sbjct: 14 AQMSEDNHLSNTNDNRERQEHNDRRSLGHPEPLSNGRPQGNS-----RQVVEQDEEEDEE 68
Query: 438 LELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
L L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 69 LTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 103
>U50871-1|AAB50054.1| 448|Homo sapiens familial Alzheimer's disease
protein.
Length = 448
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>U34349-1|AAC50290.1| 442|Homo sapiens seven trans-membrane domain
protein AD3LP/AD5 protein.
Length = 442
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>L76528-1|AAB46371.1| 467|Homo sapiens presenilin 1 protein.
Length = 467
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>L44577-1|AAC42012.1| 448|Homo sapiens E5-1 protein protein.
Length = 448
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>L43964-1|AAB59557.1| 448|Homo sapiens STM-2 protein.
Length = 448
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>L42110-1|AAB46416.1| 467|Homo sapiens S182 protein.
Length = 467
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>D84149-1|BAA20883.1| 113|Homo sapiens presenilin 1 protein.
Length = 113
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>BT006984-1|AAP35630.1| 448|Homo sapiens presenilin 2 (Alzheimer
disease 4) protein.
Length = 448
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>BC006365-1|AAH06365.1| 448|Homo sapiens PSEN2 protein protein.
Length = 448
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>AL391628-2|CAH73111.1| 481|Homo sapiens presenilin 2 (Alzheimer
disease 4) protein.
Length = 481
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 111 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 146
>AL391628-1|CAH73110.1| 448|Homo sapiens presenilin 2 (Alzheimer
disease 4) protein.
Length = 448
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>AJ008005-1|CAA07825.1| 184|Homo sapiens minilin protein.
Length = 184
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>AF416718-1|AAL16812.1| 390|Homo sapiens presenilin 2 transcript
variant 2 protein.
Length = 390
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 26/36 (72%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S Y+
Sbjct: 78 ELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYT 113
>AF416717-1|AAL16811.1| 378|Homo sapiens presenilin 1 protein.
Length = 378
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>AF109907-2|AAC97960.1| 467|Homo sapiens PS1 protein.
Length = 467
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>AC004858-2|AAF19254.1| 184|Homo sapiens minilin (short form of
presenilin 1) protein.
Length = 184
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>AC004858-1|AAF19253.1| 289|Homo sapiens presenilin 1 protein.
Length = 289
Score = 50.0 bits (114), Expect = 1e-05
Identities = 23/36 (63%), Positives = 27/36 (75%)
Frame = +3
Query: 435 ELELXYGARHVIKXFVPVTLCMLVVVAXXSSXNXYS 542
EL L YGA+HVI FVPVTLCM+VVVA S + Y+
Sbjct: 72 ELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT 107
>U04520-2|AAC27816.1| 1685|Homo sapiens type IV collagen alpha 5
chain protein.
Length = 1685
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 575 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 621
>U04520-1|AAF66217.2| 1691|Homo sapiens type IV collagen alpha 5
chain protein.
Length = 1691
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 575 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 621
>M90464-1|AAA52046.1| 910|Homo sapiens alpha-5 type IV collagen
protein.
Length = 910
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 575 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 621
>M58526-1|AAA99480.1| 1604|Homo sapiens alpha-5 type IV collagen
protein.
Length = 1604
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 494 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 540
>BC035387-1|AAH35387.1| 695|Homo sapiens COL4A5 protein protein.
Length = 695
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 183 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 229
>AL035425-1|CAB90289.2| 1685|Homo sapiens collagen type IV alpha 5
protein.
Length = 1685
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 575 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 621
>AL034369-4|CAA22267.2| 1685|Homo sapiens collagen type IV alpha 5
protein.
Length = 1685
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 575 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 621
>AL031622-1|CAI43038.1| 1685|Homo sapiens collagen type IV alpha 5
protein.
Length = 1685
Score = 31.5 bits (68), Expect = 4.7
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Frame = +3
Query: 780 PSXPRYXGXDPLTGPDXXPXGELYXPXR-PPGXVRNPXXPWAPXRVXPLG 926
P P G L GP P G + R PPG NP P P + P+G
Sbjct: 575 PGTPGQDGLPGLPGPKGEPGGITFKGERGPPG---NPGLPGLPGNIGPMG 621
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 99,012,450
Number of Sequences: 237096
Number of extensions: 1432972
Number of successful extensions: 2715
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2495
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2715
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 12603135794
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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