Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP26_F_L05
(904 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U50871-1|AAB50054.1| 448|Homo sapiens familial Alzheimer's dise... 168 2e-41
U34349-1|AAC50290.1| 442|Homo sapiens seven trans-membrane doma... 168 2e-41
L44577-1|AAC42012.1| 448|Homo sapiens E5-1 protein protein. 168 2e-41
BT006984-1|AAP35630.1| 448|Homo sapiens presenilin 2 (Alzheimer... 168 2e-41
BC006365-1|AAH06365.1| 448|Homo sapiens PSEN2 protein protein. 168 2e-41
AL391628-2|CAH73111.1| 481|Homo sapiens presenilin 2 (Alzheimer... 168 2e-41
AL391628-1|CAH73110.1| 448|Homo sapiens presenilin 2 (Alzheimer... 168 2e-41
AK223173-1|BAD96893.1| 463|Homo sapiens presenilin 1 isoform I-... 166 1e-40
U40380-1|AAB05895.1| 374|Homo sapiens presenilin I-374 protein. 165 1e-40
U40379-1|AAB05894.1| 463|Homo sapiens presenilin I-463 protein. 165 1e-40
L76528-1|AAB46371.1| 467|Homo sapiens presenilin 1 protein. 165 1e-40
L42110-1|AAB46416.1| 467|Homo sapiens S182 protein. 165 1e-40
BC011729-1|AAH11729.1| 463|Homo sapiens PSEN1 protein protein. 165 1e-40
AF109907-2|AAC97960.1| 467|Homo sapiens PS1 protein. 165 1e-40
AC004858-1|AAF19253.1| 289|Homo sapiens presenilin 1 protein. 165 1e-40
L43964-1|AAB59557.1| 448|Homo sapiens STM-2 protein. 165 2e-40
AF416718-1|AAL16812.1| 390|Homo sapiens presenilin 2 transcript... 165 2e-40
AF416717-1|AAL16811.1| 378|Homo sapiens presenilin 1 protein. 164 4e-40
L76517-1|AAB46370.1| 463|Homo sapiens presenilin 1 protein. 163 8e-40
AJ008005-1|CAA07825.1| 184|Homo sapiens minilin protein. 116 1e-25
AC004858-2|AAF19254.1| 184|Homo sapiens minilin (short form of ... 116 1e-25
D84149-1|BAA20883.1| 113|Homo sapiens presenilin 1 protein. 70 1e-11
AB159776-1|BAD30017.1| 47|Homo sapiens presenilin 1 protein. 48 6e-05
>U50871-1|AAB50054.1| 448|Homo sapiens familial Alzheimer's disease
protein.
Length = 448
Score = 168 bits (409), Expect = 2e-41
Identities = 78/157 (49%), Positives = 102/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YTPF E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>U34349-1|AAC50290.1| 442|Homo sapiens seven trans-membrane domain
protein AD3LP/AD5 protein.
Length = 442
Score = 168 bits (409), Expect = 2e-41
Identities = 78/157 (49%), Positives = 102/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YTPF E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>L44577-1|AAC42012.1| 448|Homo sapiens E5-1 protein protein.
Length = 448
Score = 168 bits (409), Expect = 2e-41
Identities = 78/157 (49%), Positives = 102/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YTPF E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>BT006984-1|AAP35630.1| 448|Homo sapiens presenilin 2 (Alzheimer
disease 4) protein.
Length = 448
Score = 168 bits (409), Expect = 2e-41
Identities = 78/157 (49%), Positives = 102/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YTPF E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>BC006365-1|AAH06365.1| 448|Homo sapiens PSEN2 protein protein.
Length = 448
Score = 168 bits (409), Expect = 2e-41
Identities = 78/157 (49%), Positives = 102/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YTPF E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>AL391628-2|CAH73111.1| 481|Homo sapiens presenilin 2 (Alzheimer
disease 4) protein.
Length = 481
Score = 168 bits (409), Expect = 2e-41
Identities = 78/157 (49%), Positives = 102/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YTPF E
Sbjct: 101 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTE 159
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 160 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 219
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 220 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 256
>AL391628-1|CAH73110.1| 448|Homo sapiens presenilin 2 (Alzheimer
disease 4) protein.
Length = 448
Score = 168 bits (409), Expect = 2e-41
Identities = 78/157 (49%), Positives = 102/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YTPF E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>AK223173-1|BAD96893.1| 463|Homo sapiens presenilin 1 isoform I-463
variant protein.
Length = 463
Score = 166 bits (403), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 63 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTPKDGQLIYTPFTEDTETVG 122
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 123 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 182
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 183 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 222
>U40380-1|AAB05895.1| 374|Homo sapiens presenilin I-374 protein.
Length = 374
Score = 165 bits (402), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 63 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 122
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 123 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 182
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 183 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 222
>U40379-1|AAB05894.1| 463|Homo sapiens presenilin I-463 protein.
Length = 463
Score = 165 bits (402), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 63 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 122
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 123 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 182
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 183 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 222
>L76528-1|AAB46371.1| 467|Homo sapiens presenilin 1 protein.
Length = 467
Score = 165 bits (402), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 126
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 127 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 186
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 187 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 226
>L42110-1|AAB46416.1| 467|Homo sapiens S182 protein.
Length = 467
Score = 165 bits (402), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 126
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 127 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 186
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 187 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 226
>BC011729-1|AAH11729.1| 463|Homo sapiens PSEN1 protein protein.
Length = 463
Score = 165 bits (402), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 63 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 122
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 123 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 182
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 183 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 222
>AF109907-2|AAC97960.1| 467|Homo sapiens PS1 protein.
Length = 467
Score = 165 bits (402), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 126
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 127 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 186
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 187 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 226
>AC004858-1|AAF19253.1| 289|Homo sapiens presenilin 1 protein.
Length = 289
Score = 165 bits (402), Expect = 1e-40
Identities = 76/160 (47%), Positives = 103/160 (64%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 126
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 127 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 186
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 187 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 226
>L43964-1|AAB59557.1| 448|Homo sapiens STM-2 protein.
Length = 448
Score = 165 bits (401), Expect = 2e-40
Identities = 77/157 (49%), Positives = 101/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YT F E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTTFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>AF416718-1|AAL16812.1| 390|Homo sapiens presenilin 2 transcript
variant 2 protein.
Length = 390
Score = 165 bits (401), Expect = 2e-40
Identities = 77/157 (49%), Positives = 101/157 (64%)
Frame = +3
Query: 393 VPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHE 572
VP P + EEL LKYGA+HVI LFVPVTLCM+VVVATI S+ FY+ K+ L YT F E
Sbjct: 68 VPGRPPGLE-EELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTTFTE 126
Query: 573 ESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXX 752
++P ++ N++ N++I++ VI +MT+ L+VLYK +CYK IHGW
Sbjct: 127 DTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYI 186
Query: 753 XXEEALIAYNIPMDYITLXFVLWNFGVMGMIVIHWXG 863
E L YN+ MDY TL +WNFG +GM+ IHW G
Sbjct: 187 YLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKG 223
>AF416717-1|AAL16811.1| 378|Homo sapiens presenilin 1 protein.
Length = 378
Score = 164 bits (398), Expect = 4e-40
Identities = 76/160 (47%), Positives = 102/160 (63%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 126
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 127 QGALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 186
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WNFGV+GMI IHW G + + L
Sbjct: 187 KTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYL 226
>L76517-1|AAB46370.1| 463|Homo sapiens presenilin 1 protein.
Length = 463
Score = 163 bits (396), Expect = 8e-40
Identities = 75/160 (46%), Positives = 102/160 (63%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 63 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 122
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWXXXXXXXXXXXXXXXXXEEAL 770
+ +++ N+ I++ VI +MT+LL+VLYK +CYK IH W E
Sbjct: 123 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVF 182
Query: 771 IAYNIPMDYITLXFVLWNFGVMGMIVIHWXGSVEATTSLL 890
YN+ +DYIT+ ++WN GV+GMI IHW G + + L
Sbjct: 183 KTYNVAVDYITVALLIWNLGVVGMISIHWKGPLRLQQAYL 222
>AJ008005-1|CAA07825.1| 184|Homo sapiens minilin protein.
Length = 184
Score = 116 bits (279), Expect = 1e-25
Identities = 53/94 (56%), Positives = 72/94 (76%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 126
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYK 692
+ +++ N+ I++ VI +MT+LL+VLYK +CYK
Sbjct: 127 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYK 160
>AC004858-2|AAF19254.1| 184|Homo sapiens minilin (short form of
presenilin 1) protein.
Length = 184
Score = 116 bits (279), Expect = 1e-25
Identities = 53/94 (56%), Positives = 72/94 (76%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYAS 590
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD L YTPF E++
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVG 126
Query: 591 TKVWNALANSMILLCVIALMTVLLIVLYKKKCYK 692
+ +++ N+ I++ VI +MT+LL+VLYK +CYK
Sbjct: 127 QRALHSILNAAIMISVIVVMTILLVVLYKYRCYK 160
>D84149-1|BAA20883.1| 113|Homo sapiens presenilin 1 protein.
Length = 113
Score = 69.7 bits (163), Expect = 1e-11
Identities = 32/44 (72%), Positives = 38/44 (86%)
Frame = +3
Query: 411 EPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKD 542
E + EEL LKYGA+HVI LFVPVTLCM+VVVATI S++FY+ KD
Sbjct: 67 EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKD 110
>AB159776-1|BAD30017.1| 47|Homo sapiens presenilin 1 protein.
Length = 47
Score = 47.6 bits (108), Expect = 6e-05
Identities = 19/46 (41%), Positives = 32/46 (69%)
Frame = +3
Query: 555 YTPFHEESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYK 692
YTPF E++ + +++ N+ I++ VI +MT+LL+VL K +CYK
Sbjct: 2 YTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLNKYRCYK 47
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 118,627,814
Number of Sequences: 237096
Number of extensions: 2322515
Number of successful extensions: 8466
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 8203
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8446
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 11659288620
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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