Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP22_F_P01
(875 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 223 5e-58
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 223 5e-58
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 223 5e-58
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 223 5e-58
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 223 5e-58
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 223 5e-58
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 223 5e-58
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 196 7e-50
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 196 9e-50
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 196 9e-50
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 196 9e-50
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 177 4e-44
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 177 4e-44
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 175 1e-43
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 175 1e-43
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 175 1e-43
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 175 1e-43
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 175 1e-43
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 175 1e-43
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 175 1e-43
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 175 2e-43
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 175 2e-43
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 175 2e-43
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 175 2e-43
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 175 2e-43
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 175 2e-43
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 175 2e-43
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 173 5e-43
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 173 5e-43
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 165 2e-40
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 165 2e-40
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 165 2e-40
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 165 2e-40
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 165 2e-40
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 165 2e-40
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 158 2e-38
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 158 2e-38
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 157 7e-38
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 122 2e-27
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 65 4e-10
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 65 4e-10
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 65 4e-10
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 65 4e-10
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 65 4e-10
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 65 4e-10
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 65 4e-10
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 65 4e-10
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 65 4e-10
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 65 4e-10
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 65 4e-10
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 64 8e-10
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 61 4e-09
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 61 4e-09
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 61 4e-09
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 61 4e-09
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 61 4e-09
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 61 4e-09
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 61 4e-09
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 61 4e-09
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 60 1e-08
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 59 2e-08
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 56 1e-07
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 56 1e-07
AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinog... 52 3e-06
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 48 3e-05
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 42 0.002
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.003
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.003
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 39 0.027
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 37 0.11
AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant... 35 0.34
AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protei... 32 2.4
AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens ... 32 3.1
BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain cont... 31 7.2
BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member ... 25 9.0
AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens ... 25 9.0
BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated prot... 30 9.6
BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated prot... 30 9.6
AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated prot... 30 9.6
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 223 bits (546), Expect = 5e-58
Identities = 120/232 (51%), Positives = 145/232 (62%), Gaps = 22/232 (9%)
Frame = +2
Query: 200 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 346
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 673
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 674 VAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
+AAKFDGILGMA+ I+V++V PVFD ++ FYL+RDP G
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 223 bits (546), Expect = 5e-58
Identities = 120/232 (51%), Positives = 145/232 (62%), Gaps = 22/232 (9%)
Frame = +2
Query: 200 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 346
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 673
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 674 VAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
+AAKFDGILGMA+ I+V++V PVFD ++ FYL+RDP G
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 223 bits (546), Expect = 5e-58
Identities = 120/232 (51%), Positives = 145/232 (62%), Gaps = 22/232 (9%)
Frame = +2
Query: 200 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 346
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 673
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 674 VAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
+AAKFDGILGMA+ I+V++V PVFD ++ FYL+RDP G
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 223 bits (546), Expect = 5e-58
Identities = 120/232 (51%), Positives = 145/232 (62%), Gaps = 22/232 (9%)
Frame = +2
Query: 200 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 346
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 673
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 674 VAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
+AAKFDGILGMA+ I+V++V PVFD ++ FYL+RDP G
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 223 bits (546), Expect = 5e-58
Identities = 120/232 (51%), Positives = 145/232 (62%), Gaps = 22/232 (9%)
Frame = +2
Query: 200 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 346
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 673
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 674 VAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
+AAKFDGILGMA+ I+V++V PVFD ++ FYL+RDP G
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 223 bits (546), Expect = 5e-58
Identities = 120/232 (51%), Positives = 145/232 (62%), Gaps = 22/232 (9%)
Frame = +2
Query: 200 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 346
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 673
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 674 VAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
+AAKFDGILGMA+ I+V++V PVFD ++ FYL+RDP G
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 223 bits (546), Expect = 5e-58
Identities = 120/232 (51%), Positives = 145/232 (62%), Gaps = 22/232 (9%)
Frame = +2
Query: 200 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 346
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 673
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 674 VAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
+AAKFDGILGMA+ I+V++V PVFD ++ FYL+RDP G
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 196 bits (479), Expect = 7e-50
Identities = 97/212 (45%), Positives = 130/212 (61%), Gaps = 5/212 (2%)
Frame = +2
Query: 209 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 373
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 374 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 553
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 554 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 733
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 734 VTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
V P D +V G FYLNRDP G
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDG 230
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 196 bits (478), Expect = 9e-50
Identities = 97/212 (45%), Positives = 130/212 (61%), Gaps = 5/212 (2%)
Frame = +2
Query: 209 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 373
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 374 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 553
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 554 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 733
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 734 VTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
V P D +V G FYLNRDP G
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDG 230
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 196 bits (478), Expect = 9e-50
Identities = 97/212 (45%), Positives = 130/212 (61%), Gaps = 5/212 (2%)
Frame = +2
Query: 209 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 373
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 374 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 553
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 554 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 733
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 734 VTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
V P D +V G FYLNRDP G
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDG 230
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 196 bits (478), Expect = 9e-50
Identities = 97/212 (45%), Positives = 130/212 (61%), Gaps = 5/212 (2%)
Frame = +2
Query: 209 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 373
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 374 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 553
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 554 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 733
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 734 VTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
V P D +V G FYLNRDP G
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDG 230
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 177 bits (431), Expect = 4e-44
Identities = 86/200 (43%), Positives = 122/200 (61%), Gaps = 5/200 (2%)
Frame = +2
Query: 230 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 394
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 395 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 574
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 141
Query: 575 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDX 754
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 142 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 201
Query: 755 MVASGTRAAXSSRFYLNRDP 814
+V G FY NRDP
Sbjct: 202 LVEQGLLDKPVFSFYFNRDP 221
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 177 bits (431), Expect = 4e-44
Identities = 86/200 (43%), Positives = 122/200 (61%), Gaps = 5/200 (2%)
Frame = +2
Query: 230 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 394
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 395 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 574
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 145
Query: 575 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDX 754
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 146 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 205
Query: 755 MVASGTRAAXSSRFYLNRDP 814
+V G FY NRDP
Sbjct: 206 LVEQGLLDKPVFSFYFNRDP 225
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 175 bits (427), Expect = 1e-43
Identities = 79/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 175 bits (427), Expect = 1e-43
Identities = 79/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 175 bits (427), Expect = 1e-43
Identities = 79/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 175 bits (427), Expect = 1e-43
Identities = 79/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 175 bits (427), Expect = 1e-43
Identities = 79/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 175 bits (427), Expect = 1e-43
Identities = 79/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 175 bits (427), Expect = 1e-43
Identities = 79/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 175 bits (426), Expect = 2e-43
Identities = 96/223 (43%), Positives = 132/223 (59%), Gaps = 10/223 (4%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 340
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 341 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 520
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 521 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 700
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 701 GMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
G+ + ++AV VTPVFD M+A Y++ +P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAG 228
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 175 bits (426), Expect = 2e-43
Identities = 96/223 (43%), Positives = 132/223 (59%), Gaps = 10/223 (4%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 340
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 341 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 520
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 521 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 700
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 701 GMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
G+ + ++AV VTPVFD M+A Y++ +P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAG 228
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 175 bits (426), Expect = 2e-43
Identities = 96/223 (43%), Positives = 132/223 (59%), Gaps = 10/223 (4%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 340
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 341 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 520
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 521 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 700
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 701 GMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
G+ + ++AV VTPVFD M+A Y++ +P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAG 228
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 175 bits (426), Expect = 2e-43
Identities = 96/223 (43%), Positives = 132/223 (59%), Gaps = 10/223 (4%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 340
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 341 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 520
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 521 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 700
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 701 GMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
G+ + ++AV VTPVFD M+A Y++ +P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAG 228
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 175 bits (426), Expect = 2e-43
Identities = 96/223 (43%), Positives = 132/223 (59%), Gaps = 10/223 (4%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 340
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 341 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 520
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 521 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 700
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 701 GMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
G+ + ++AV VTPVFD M+A Y++ +P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAG 228
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 175 bits (426), Expect = 2e-43
Identities = 96/223 (43%), Positives = 132/223 (59%), Gaps = 10/223 (4%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 340
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 341 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 520
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 521 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 700
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 701 GMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
G+ + ++AV VTPVFD M+A Y++ +P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAG 228
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 175 bits (426), Expect = 2e-43
Identities = 96/223 (43%), Positives = 132/223 (59%), Gaps = 10/223 (4%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 340
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 341 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 520
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 521 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 700
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 701 GMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
G+ + ++AV VTPVFD M+A Y++ +P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAG 228
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 173 bits (422), Expect = 5e-43
Identities = 78/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAQFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRN 231
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 173 bits (422), Expect = 5e-43
Identities = 78/155 (50%), Positives = 104/155 (67%)
Frame = +2
Query: 347 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 526
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 527 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 706
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 707 AFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
F A+ VTP+FD +++ G FY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRN 231
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 165 bits (400), Expect = 2e-40
Identities = 90/210 (42%), Positives = 123/210 (58%), Gaps = 9/210 (4%)
Frame = +2
Query: 227 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 379
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 380 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 559
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 560 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 739
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 740 PVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
MV G + YL+ G G
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSSGG 223
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 165 bits (400), Expect = 2e-40
Identities = 90/210 (42%), Positives = 123/210 (58%), Gaps = 9/210 (4%)
Frame = +2
Query: 227 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 379
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 380 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 559
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 560 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 739
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 740 PVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
MV G + YL+ G G
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSSGG 223
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 165 bits (400), Expect = 2e-40
Identities = 90/210 (42%), Positives = 123/210 (58%), Gaps = 9/210 (4%)
Frame = +2
Query: 227 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 379
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 380 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 559
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 130
Query: 560 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 739
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 131 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 190
Query: 740 PVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
MV G + YL+ G G
Sbjct: 191 TAMQGMVQEGALTSPVFSVYLSNQQGSSGG 220
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 165 bits (400), Expect = 2e-40
Identities = 90/210 (42%), Positives = 123/210 (58%), Gaps = 9/210 (4%)
Frame = +2
Query: 227 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 379
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 380 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 559
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 560 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 739
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 740 PVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
MV G + YL+ G G
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSSGG 223
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 165 bits (400), Expect = 2e-40
Identities = 90/210 (42%), Positives = 123/210 (58%), Gaps = 9/210 (4%)
Frame = +2
Query: 227 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 379
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 380 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 559
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 560 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 739
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 740 PVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
MV G + YL+ G G
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSSGG 223
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 165 bits (400), Expect = 2e-40
Identities = 90/210 (42%), Positives = 123/210 (58%), Gaps = 9/210 (4%)
Frame = +2
Query: 227 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 379
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 380 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 559
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 560 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 739
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 740 PVFDXMVASGTRAAXSSRFYLNRDPGXDTG 829
MV G + YL+ G G
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSSGG 223
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 158 bits (384), Expect = 2e-38
Identities = 90/219 (41%), Positives = 121/219 (55%), Gaps = 12/219 (5%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 340
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 341 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 514
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 515 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 694
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 695 ILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
ILG+A+ +I+ TPVFD + G + YL+ D
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 158 bits (384), Expect = 2e-38
Identities = 90/219 (41%), Positives = 121/219 (55%), Gaps = 12/219 (5%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 340
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 341 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 514
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 515 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 694
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 695 ILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
ILG+A+ +I+ TPVFD + G + YL+ D
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 157 bits (380), Expect = 7e-38
Identities = 89/219 (40%), Positives = 121/219 (55%), Gaps = 12/219 (5%)
Frame = +2
Query: 191 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 340
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
Query: 341 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 514
+PL NYLD +Y+G I IGTP Q F V+FDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 515 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 694
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 695 ILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRFYLNRD 811
ILG+A+ +I+ TPVFD + G + YL+ D
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 122 bits (293), Expect = 2e-27
Identities = 55/125 (44%), Positives = 77/125 (61%)
Frame = +2
Query: 437 SNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 616
SN+WVPS KC AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 1 SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGG 60
Query: 617 LKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXSSRF 796
+ V Q F E P L F+ A+FDG++GM F A+ VTP+FD +++ G F
Sbjct: 61 ITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF 119
Query: 797 YLNRD 811
Y NRD
Sbjct: 120 YYNRD 124
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 66
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 67 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 126
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 64.9 bits (151), Expect = 4e-10
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 63.7 bits (148), Expect = 8e-10
Identities = 38/114 (33%), Positives = 60/114 (52%), Gaps = 2/114 (1%)
Frame = +2
Query: 389 IGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGS 568
IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G ++Y
Sbjct: 3 IGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQ 56
Query: 569 GSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
GS +GF+ D VT+ G + E G F+ +++GILG+A++T+A
Sbjct: 57 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESGNFFLPGIQWNGILGLAYATLA 110
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 189 RPDDSLEPFFDSLV 202
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 189 RPDDSLEPFFDSLV 202
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 189 RPDDSLEPFFDSLV 202
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 189 RPDDSLEPFFDSLV 202
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 189 RPDDSLEPFFDSLV 202
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 115
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 116 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 175
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 176 RPDDSLEPFFDSLV 189
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 189 RPDDSLEPFFDSLV 202
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 61.3 bits (142), Expect = 4e-09
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 159
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 160 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 219
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 220 RPDDSLEPFFDSLV 233
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 60.1 bits (139), Expect = 1e-08
Identities = 38/82 (46%), Positives = 49/82 (59%), Gaps = 9/82 (10%)
Frame = +2
Query: 227 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 379
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 380 VISIGTPPQSFKVVFDTGSSNL 445
ISIGTPPQ+F V+FDTGSS L
Sbjct: 76 EISIGTPPQNFLVLFDTGSSPL 97
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 58.8 bits (136), Expect = 2e-08
Identities = 42/134 (31%), Positives = 67/134 (50%), Gaps = 4/134 (2%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLFSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 725 --VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 189 RPDDSLEPFFDSLV 202
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 56.4 bits (130), Expect = 1e-07
Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 56.4 bits (130), Expect = 1e-07
Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 140
Score = 52.0 bits (119), Expect = 3e-06
Identities = 25/70 (35%), Positives = 37/70 (52%)
Frame = +2
Query: 608 VGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDXMVASGTRAAXS 787
V ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T MV G +
Sbjct: 71 VQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPV 130
Query: 788 SRFYLNRDPG 817
YL+ G
Sbjct: 131 FSVYLSNQQG 140
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 48.4 bits (110), Expect = 3e-05
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 2/106 (1%)
Frame = +2
Query: 413 KVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLS 592
+++ DTGSSN V Y + +D+ +S TY + G ++Y GS +GF+
Sbjct: 3 QILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVG 56
Query: 593 TDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 724
D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 57 EDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 102
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 42.3 bits (95), Expect = 0.002
Identities = 27/94 (28%), Positives = 42/94 (44%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAV 652
+ Y G G L TD + G + + +V
Sbjct: 129 YVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASV 162
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.003
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTD 598
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.003
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 550
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 551 AIQYGSGSLSGFLSTD 598
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 38.7 bits (86), Expect = 0.027
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Frame = +2
Query: 218 SVMALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 370
+V+ RVPL + K+ R E G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 371 YYGVISIGTP 400
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 36.7 bits (81), Expect = 0.11
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +2
Query: 371 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTY 529
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant 1
protein.
Length = 396
Score = 35.1 bits (77), Expect = 0.34
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 4/73 (5%)
Frame = +2
Query: 554 IQYGSGSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA- 724
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 25 VPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR 84
Query: 725 -VDHVTPVFDXMV 760
D + P FD +V
Sbjct: 85 PDDSLEPFFDSLV 97
>AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protein
LIP8 protein.
Length = 119
Score = 32.3 bits (70), Expect = 2.4
Identities = 13/33 (39%), Positives = 16/33 (48%)
Frame = -1
Query: 593 WRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCC 495
W GS+R C + V + S SW CR CC
Sbjct: 8 WPGSKRECANCRVGTSSWRSSGWSWWKDCRPCC 40
>AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens
cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (EC
2.7.7.6). ).
Length = 260
Score = 31.9 bits (69), Expect = 3.1
Identities = 17/35 (48%), Positives = 18/35 (51%)
Frame = -1
Query: 602 HHQWRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTC 498
H+ W GS R C S T S G HS SWT R C
Sbjct: 26 HNSWTGSNRACSSWTGSTRG-HS---SWTGSSRAC 56
>BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain
containing 11 protein.
Length = 514
Score = 30.7 bits (66), Expect = 7.2
Identities = 12/26 (46%), Positives = 18/26 (69%)
Frame = -2
Query: 436 GSGVEYHLERLRRRADTDHSVVLSIK 359
G G E+HLER+RR ++++ SIK
Sbjct: 30 GQGAEHHLERIRRSHQKHNAILASIK 55
>BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member 12
protein.
Length = 578
Score = 25.4 bits (53), Expect(2) = 9.0
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -1
Query: 362 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 210
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 9.0
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -1
Query: 509 CRTCCAANKRCWCSGTFWKAPRGWRIR 429
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ10260 fis, clone HEMBB1000973, moderately
similar to Mus musculus schlafen3 mRNA. ).
Length = 578
Score = 25.4 bits (53), Expect(2) = 9.0
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -1
Query: 362 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 210
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINASLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 9.0
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -1
Query: 509 CRTCCAANKRCWCSGTFWKAPRGWRIR 429
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 9.6
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 587 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 468
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 9.6
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 587 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 468
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated protein
protein.
Length = 129
Score = 30.3 bits (65), Expect = 9.6
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 587 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 468
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 121,714,642
Number of Sequences: 237096
Number of extensions: 2666970
Number of successful extensions: 7354
Number of sequences better than 10.0: 79
Number of HSP's better than 10.0 without gapping: 6584
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7272
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 11159604822
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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