Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP19_F_P09
(916 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein. 167 4e-41
BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofola... 167 4e-41
BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofola... 167 4e-41
X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for ... 98 4e-20
BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofola... 98 4e-20
BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofol... 98 4e-20
AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein. 98 4e-20
AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofol... 96 1e-19
AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofol... 96 1e-19
AY374131-1|AAQ82697.1| 275|Homo sapiens truncated C1-tetrahydro... 76 2e-13
AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate syn... 76 2e-13
AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofola... 76 2e-13
AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein pr... 76 2e-13
AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofola... 76 2e-13
AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofola... 76 2e-13
AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofola... 76 2e-13
AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofola... 76 2e-13
AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial C1-tetrah... 76 2e-13
BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein. 76 2e-13
BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofola... 65 4e-10
BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein. 64 7e-10
AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofola... 61 5e-09
BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein. 48 6e-05
AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15... 38 0.067
AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofola... 34 0.83
AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofola... 34 0.83
>J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein.
Length = 935
Score = 167 bits (407), Expect = 4e-41
Identities = 80/143 (55%), Positives = 111/143 (77%), Gaps = 1/143 (0%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI A HI+LPR TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 448 VDGLNTINEGRVAVGDLSG-FIP 513
VDGL +IN GR+A GDL+ FIP
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIP 146
Score = 78.6 bits (185), Expect = 3e-14
Identities = 41/81 (50%), Positives = 50/81 (61%), Gaps = 1/81 (1%)
Frame = +2
Query: 503 DSFLX-TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHATVXVCHSKTXX 679
D F+ TP GC+ELIK+ GV IAG++ VV+ S+ VG P+ LL W +ATV CHSKT
Sbjct: 142 DCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAH 201
Query: 680 LXEITXTXXXLVVAIXPPXMV 742
L E LVVA P MV
Sbjct: 202 LDEEVNKGDILVVATGQPEMV 222
>BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 167 bits (407), Expect = 4e-41
Identities = 80/143 (55%), Positives = 111/143 (77%), Gaps = 1/143 (0%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI A HI+LPR TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 448 VDGLNTINEGRVAVGDLSG-FIP 513
VDGL +IN GR+A GDL+ FIP
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIP 146
Score = 78.6 bits (185), Expect = 3e-14
Identities = 41/81 (50%), Positives = 50/81 (61%), Gaps = 1/81 (1%)
Frame = +2
Query: 503 DSFLX-TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHATVXVCHSKTXX 679
D F+ TP GC+ELIK+ GV IAG++ VV+ S+ VG P+ LL W +ATV CHSKT
Sbjct: 142 DCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAH 201
Query: 680 LXEITXTXXXLVVAIXPPXMV 742
L E LVVA P MV
Sbjct: 202 LDEEVNKGDILVVATGQPEMV 222
>BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 167 bits (407), Expect = 4e-41
Identities = 80/143 (55%), Positives = 111/143 (77%), Gaps = 1/143 (0%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI A HI+LPR TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 448 VDGLNTINEGRVAVGDLSG-FIP 513
VDGL +IN GR+A GDL+ FIP
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIP 146
Score = 78.6 bits (185), Expect = 3e-14
Identities = 41/81 (50%), Positives = 50/81 (61%), Gaps = 1/81 (1%)
Frame = +2
Query: 503 DSFLX-TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHATVXVCHSKTXX 679
D F+ TP GC+ELIK+ GV IAG++ VV+ S+ VG P+ LL W +ATV CHSKT
Sbjct: 142 DCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAH 201
Query: 680 LXEITXTXXXLVVAIXPPXMV 742
L E LVVA P MV
Sbjct: 202 LDEEVNKGDILVVATGQPEMV 222
>X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for
NAD-dependent methylene tetrahydrofolate dehydrogenase
cyclohydrolase (EC 1.5.1.15). ).
Length = 344
Score = 97.9 bits (233), Expect = 4e-20
Identities = 56/138 (40%), Positives = 84/138 (60%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A +ISG ++A I+ ++RQ+V + + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNK-RPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI +E I P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKD
Sbjct: 90 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKD 147
Query: 448 VDGLNTINEGRVAVGDLS 501
VDG + IN GR+ + S
Sbjct: 148 VDGFHVINVGRMCLDQYS 165
Score = 41.1 bits (92), Expect = 0.005
Identities = 20/43 (46%), Positives = 27/43 (62%)
Frame = +2
Query: 518 TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHA 646
TP G E+IK+ G+ GKNVVV S+ VG P++ LL + A
Sbjct: 170 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA 212
>BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 350
Score = 97.9 bits (233), Expect = 4e-20
Identities = 56/138 (40%), Positives = 84/138 (60%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A +ISG ++A I+ ++RQ+V + + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNK-RPHLSVILVGENPASHSYVLNKTRAAAVV 95
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI +E I P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKD
Sbjct: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKD 153
Query: 448 VDGLNTINEGRVAVGDLS 501
VDG + IN GR+ + S
Sbjct: 154 VDGFHVINVGRMCLDQYS 171
Score = 41.1 bits (92), Expect = 0.005
Identities = 20/43 (46%), Positives = 27/43 (62%)
Frame = +2
Query: 518 TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHA 646
TP G E+IK+ G+ GKNVVV S+ VG P++ LL + A
Sbjct: 176 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA 218
>BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2, precursor protein.
Length = 344
Score = 97.9 bits (233), Expect = 4e-20
Identities = 56/138 (40%), Positives = 84/138 (60%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A +ISG ++A I+ ++RQ+V + + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNK-RPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI +E I P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKD
Sbjct: 90 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKD 147
Query: 448 VDGLNTINEGRVAVGDLS 501
VDG + IN GR+ + S
Sbjct: 148 VDGFHVINVGRMCLDQYS 165
Score = 41.1 bits (92), Expect = 0.005
Identities = 20/43 (46%), Positives = 27/43 (62%)
Frame = +2
Query: 518 TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHA 646
TP G E+IK+ G+ GKNVVV S+ VG P++ LL + A
Sbjct: 170 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA 212
>AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein.
Length = 344
Score = 97.9 bits (233), Expect = 4e-20
Identities = 56/138 (40%), Positives = 84/138 (60%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A +ISG ++A I+ ++RQ+V + + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNK-RPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI +E I P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKD
Sbjct: 90 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKD 147
Query: 448 VDGLNTINEGRVAVGDLS 501
VDG + IN GR+ + S
Sbjct: 148 VDGFHVINVGRMCLDQYS 165
Score = 41.1 bits (92), Expect = 0.005
Identities = 20/43 (46%), Positives = 27/43 (62%)
Frame = +2
Query: 518 TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHA 646
TP G E+IK+ G+ GKNVVV S+ VG P++ LL + A
Sbjct: 170 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA 212
>AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 96.3 bits (229), Expect = 1e-19
Identities = 56/138 (40%), Positives = 83/138 (60%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A +ISG ++A I+ ++RQ+V + + P L+++ VG S+ Y+ K +AA
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNK-RPHLSVILVGENPASHSYVLNKTRAAAVA 89
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI +E I P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKD
Sbjct: 90 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKD 147
Query: 448 VDGLNTINEGRVAVGDLS 501
VDG + IN GR+ + S
Sbjct: 148 VDGFHVINVGRMCLDQYS 165
Score = 41.1 bits (92), Expect = 0.005
Identities = 20/43 (46%), Positives = 27/43 (62%)
Frame = +2
Query: 518 TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHA 646
TP G E+IK+ G+ GKNVVV S+ VG P++ LL + A
Sbjct: 170 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA 212
>AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 96.3 bits (229), Expect = 1e-19
Identities = 55/138 (39%), Positives = 83/138 (60%)
Frame = +1
Query: 88 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 267
A +ISG ++A I+ ++RQ+V + + P L+++ G S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNK-RPHLSVILAGENPASHSYVLNKTRAAAVV 89
Query: 268 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 447
GI +E I P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKD
Sbjct: 90 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKD 147
Query: 448 VDGLNTINEGRVAVGDLS 501
VDG + IN GR+ + S
Sbjct: 148 VDGFHVINVGRMCLDQYS 165
Score = 41.1 bits (92), Expect = 0.005
Identities = 20/43 (46%), Positives = 27/43 (62%)
Frame = +2
Query: 518 TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHA 646
TP G E+IK+ G+ GKNVVV S+ VG P++ LL + A
Sbjct: 170 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA 212
>AY374131-1|AAQ82697.1| 275|Homo sapiens truncated
C1-tetrahydrofolate synthase protein.
Length = 275
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 135 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 190
Query: 484 AVGD 495
GD
Sbjct: 191 VRGD 194
>AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate
synthase protein.
Length = 978
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 135 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 190
Query: 484 AVGD 495
GD
Sbjct: 191 VRGD 194
>AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 135 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 190
Query: 484 AVGD 495
GD
Sbjct: 191 VRGD 194
>AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein
protein.
Length = 917
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 18 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 73
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 74 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 129
Query: 484 AVGD 495
GD
Sbjct: 130 VRGD 133
>AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 38 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 94 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 149
Query: 484 AVGD 495
GD
Sbjct: 150 VRGD 153
>AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 135 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 190
Query: 484 AVGD 495
GD
Sbjct: 191 VRGD 194
>AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 38 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 94 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 149
Query: 484 AVGD 495
GD
Sbjct: 150 VRGD 153
>AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 135 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 190
Query: 484 AVGD 495
GD
Sbjct: 191 VRGD 194
>AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial
C1-tetrahydrofolate synthetase protein.
Length = 978
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/124 (34%), Positives = 73/124 (58%)
Frame = +1
Query: 124 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 303
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 304 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 483
+E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++
Sbjct: 135 SSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKL 190
Query: 484 AVGD 495
GD
Sbjct: 191 VRGD 194
>BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein.
Length = 900
Score = 75.8 bits (178), Expect = 2e-13
Identities = 41/119 (34%), Positives = 70/119 (58%)
Frame = +1
Query: 139 RQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIE 318
++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D +E E
Sbjct: 5 KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPDSSEAE 61
Query: 319 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD 495
++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 62 IIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKLVRGD 116
>BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 248
Score = 64.9 bits (151), Expect = 4e-10
Identities = 34/69 (49%), Positives = 45/69 (65%)
Frame = +1
Query: 295 PRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINE 474
P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN
Sbjct: 3 PASISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINV 60
Query: 475 GRVAVGDLS 501
GR+ + S
Sbjct: 61 GRMCLDQYS 69
Score = 41.1 bits (92), Expect = 0.005
Identities = 20/43 (46%), Positives = 27/43 (62%)
Frame = +2
Query: 518 TPAGCVELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLLKWEHA 646
TP G E+IK+ G+ GKNVVV S+ VG P++ LL + A
Sbjct: 74 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA 116
>BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein.
Length = 106
Score = 64.1 bits (149), Expect = 7e-10
Identities = 30/68 (44%), Positives = 44/68 (64%)
Frame = +1
Query: 184 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 363
P L+I+ VG S+ Y+R K++AA +GI +E I P+D+++ ELL LN P V
Sbjct: 24 PHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVS 83
Query: 364 GIIVQMPL 387
GI+VQ+PL
Sbjct: 84 GILVQLPL 91
>AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 114
Score = 61.3 bits (142), Expect = 5e-09
Identities = 30/80 (37%), Positives = 50/80 (62%)
Frame = +1
Query: 256 AEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVS 435
AE+ G+ HI LP D +E E++ +I +NE VHG+ +Q+ + +++V +A+
Sbjct: 9 AEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALK 64
Query: 436 PDKDVDGLNTINEGRVAVGD 495
P+KDVDG+ IN G++ GD
Sbjct: 65 PEKDVDGVTDINLGKLVRGD 84
>BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein.
Length = 146
Score = 47.6 bits (108), Expect = 6e-05
Identities = 25/60 (41%), Positives = 37/60 (61%)
Frame = +1
Query: 352 PSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGDLSGFIPXHSGRV 531
P V GI+VQ+PL DH +D + + ++P+KDVDG + IN GR+ + D IP + V
Sbjct: 3 PRVSGILVQLPLP-DH-VDERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAV 59
Score = 37.1 bits (82), Expect = 0.089
Identities = 28/71 (39%), Positives = 37/71 (52%), Gaps = 11/71 (15%)
Frame = +2
Query: 494 ICPD--SFLXTPAGCV-ELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLL--KWEH----- 643
+C D S + A V E+IK+ G+ GKNVVV S+ VG P++ LL EH
Sbjct: 44 LCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGG 103
Query: 644 -ATVXVCHSKT 673
ATV + H T
Sbjct: 104 DATVTIAHRYT 114
>AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15).
protein.
Length = 236
Score = 37.5 bits (83), Expect = 0.067
Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 13/96 (13%)
Frame = +2
Query: 494 ICPD--SFLXTPAGCV-ELIKKXGVTIAGKNVVVLXPSRXVGXPVSXLL--KWEH----- 643
+C D S + A V E+IK+ G+ GKNVVV S+ VG P++ LL EH
Sbjct: 68 LCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGG 127
Query: 644 -ATVXVCHSKT--XXLXEITXTXXXLVVAIXPPXMV 742
ATV + H T L T ++VA P ++
Sbjct: 128 DATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLI 163
Score = 33.9 bits (74), Expect = 0.83
Identities = 15/43 (34%), Positives = 25/43 (58%)
Frame = +1
Query: 403 IDAHRVTDAVSPDKDVDGLNTINEGRVAVGDLSGFIPXHSGRV 531
+D + + ++P+KDVDG + IN GR+ + D IP + V
Sbjct: 42 VDERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAV 83
>AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 33.9 bits (74), Expect = 0.83
Identities = 13/29 (44%), Positives = 22/29 (75%)
Frame = +1
Query: 409 AHRVTDAVSPDKDVDGLNTINEGRVAVGD 495
+++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 10 SNKVLNALKPEKDVDGVTDINLGKLVRGD 38
>AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 33.9 bits (74), Expect = 0.83
Identities = 13/29 (44%), Positives = 22/29 (75%)
Frame = +1
Query: 409 AHRVTDAVSPDKDVDGLNTINEGRVAVGD 495
+++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 11 SNKVLNALKPEKDVDGVTDINLGKLVRGD 39
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 116,941,734
Number of Sequences: 237096
Number of extensions: 2193187
Number of successful extensions: 5654
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 5372
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5610
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 11881370308
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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