Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP18_F_L03
(859 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein. 132 2e-30
BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofola... 132 2e-30
BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofola... 132 2e-30
X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for ... 65 4e-10
BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofola... 65 4e-10
BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofola... 65 4e-10
BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofol... 65 4e-10
AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofol... 65 4e-10
AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofol... 65 4e-10
AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein. 65 4e-10
BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein. 63 1e-09
AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15... 60 1e-08
BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein. 57 7e-08
BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein. 49 3e-05
AY374131-1|AAQ82697.1| 275|Homo sapiens truncated C1-tetrahydro... 49 3e-05
AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate syn... 49 3e-05
AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofola... 49 3e-05
AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein pr... 49 3e-05
AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofola... 49 3e-05
AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofola... 49 3e-05
AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofola... 49 3e-05
AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofola... 49 3e-05
AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial C1-tetrah... 49 3e-05
AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofola... 40 0.009
AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofola... 40 0.009
AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofola... 36 0.19
AB028945-1|BAA82974.1| 1131|Homo sapiens KIAA1022 protein protein. 33 1.3
>J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein.
Length = 935
Score = 132 bits (318), Expect = 2e-30
Identities = 69/141 (48%), Positives = 84/141 (59%), Gaps = 1/141 (0%)
Frame = +2
Query: 377 LFKCPLIRTTRSTLIESLMLSRPDKDVDGLXTINEGRVAVGDLSG-FIPXTPAGCVELIK 553
L + PL E + P+KDVDGL +IN GR+A GDL+ FIP TP GC+ELIK
Sbjct: 98 LVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIK 157
Query: 554 KTGVXIAGXNVVXLXRSXIVGTPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIG 733
+TGV IAG + V + RS IVG P+ +LL W ATV C S T L E LVVA G
Sbjct: 158 ETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATG 217
Query: 734 RPXMVRGSWIXPXXVXIXCXI 796
+P MV+G WI P + I C I
Sbjct: 218 QPEMVKGEWIKPGAIVIDCGI 238
Score = 111 bits (266), Expect = 4e-24
Identities = 51/87 (58%), Positives = 69/87 (79%)
Frame = +1
Query: 181 GFEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESP 360
GF PRLAI+QVG R+ SN+YI +KLKAAE+IGI A HI+LPR TE E++ ITSLNE
Sbjct: 33 GFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDS 92
Query: 361 SVHGIIVQMPLDSDHAIDAHRVXDAVS 441
+VHG +VQ+PLDS+++I+ V +A++
Sbjct: 93 TVHGFLVQLPLDSENSINTEEVINAIA 119
>BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 132 bits (318), Expect = 2e-30
Identities = 69/141 (48%), Positives = 84/141 (59%), Gaps = 1/141 (0%)
Frame = +2
Query: 377 LFKCPLIRTTRSTLIESLMLSRPDKDVDGLXTINEGRVAVGDLSG-FIPXTPAGCVELIK 553
L + PL E + P+KDVDGL +IN GR+A GDL+ FIP TP GC+ELIK
Sbjct: 98 LVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIK 157
Query: 554 KTGVXIAGXNVVXLXRSXIVGTPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIG 733
+TGV IAG + V + RS IVG P+ +LL W ATV C S T L E LVVA G
Sbjct: 158 ETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATG 217
Query: 734 RPXMVRGSWIXPXXVXIXCXI 796
+P MV+G WI P + I C I
Sbjct: 218 QPEMVKGEWIKPGAIVIDCGI 238
Score = 111 bits (266), Expect = 4e-24
Identities = 51/87 (58%), Positives = 69/87 (79%)
Frame = +1
Query: 181 GFEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESP 360
GF PRLAI+QVG R+ SN+YI +KLKAAE+IGI A HI+LPR TE E++ ITSLNE
Sbjct: 33 GFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDS 92
Query: 361 SVHGIIVQMPLDSDHAIDAHRVXDAVS 441
+VHG +VQ+PLDS+++I+ V +A++
Sbjct: 93 TVHGFLVQLPLDSENSINTEEVINAIA 119
>BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 132 bits (318), Expect = 2e-30
Identities = 69/141 (48%), Positives = 84/141 (59%), Gaps = 1/141 (0%)
Frame = +2
Query: 377 LFKCPLIRTTRSTLIESLMLSRPDKDVDGLXTINEGRVAVGDLSG-FIPXTPAGCVELIK 553
L + PL E + P+KDVDGL +IN GR+A GDL+ FIP TP GC+ELIK
Sbjct: 98 LVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIK 157
Query: 554 KTGVXIAGXNVVXLXRSXIVGTPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIG 733
+TGV IAG + V + RS IVG P+ +LL W ATV C S T L E LVVA G
Sbjct: 158 ETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATG 217
Query: 734 RPXMVRGSWIXPXXVXIXCXI 796
+P MV+G WI P + I C I
Sbjct: 218 QPEMVKGEWIKPGAIVIDCGI 238
Score = 111 bits (266), Expect = 4e-24
Identities = 51/87 (58%), Positives = 69/87 (79%)
Frame = +1
Query: 181 GFEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESP 360
GF PRLAI+QVG R+ SN+YI +KLKAAE+IGI A HI+LPR TE E++ ITSLNE
Sbjct: 33 GFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDS 92
Query: 361 SVHGIIVQMPLDSDHAIDAHRVXDAVS 441
+VHG +VQ+PLDS+++I+ V +A++
Sbjct: 93 TVHGFLVQLPLDSENSINTEEVINAIA 119
>X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for
NAD-dependent methylene tetrahydrofolate dehydrogenase
cyclohydrolase (EC 1.5.1.15). ).
Length = 344
Score = 64.9 bits (151), Expect = 4e-10
Identities = 45/131 (34%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
PDKDVDG IN GR+ + S +P TP G E+IK+TG+ G NVV RS VG P
Sbjct: 144 PDKDVDGFHVINVGRMCLDQYS-MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMP 202
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWIXPX 772
++ LL + ATV + T L + T A ++ A G P ++ I
Sbjct: 203 IAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG 262
Query: 773 XVXIXCXIXAI 805
I I +
Sbjct: 263 AAVIDVGINRV 273
Score = 60.5 bits (140), Expect = 8e-09
Identities = 34/84 (40%), Positives = 50/84 (59%)
Frame = +1
Query: 190 PRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVH 369
P L+++ VG S+ Y+ K +AA +GI +E I P +E ELL I LN +V
Sbjct: 62 PHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVD 121
Query: 370 GIIVQMPLDSDHAIDAHRVXDAVS 441
G++VQ+PL +H ID R+ +AVS
Sbjct: 122 GLLVQLPL-PEH-IDERRICNAVS 143
>BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 350
Score = 64.9 bits (151), Expect = 4e-10
Identities = 45/131 (34%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
PDKDVDG IN GR+ + S +P TP G E+IK+TG+ G NVV RS VG P
Sbjct: 150 PDKDVDGFHVINVGRMCLDQYS-MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMP 208
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWIXPX 772
++ LL + ATV + T L + T A ++ A G P ++ I
Sbjct: 209 IAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG 268
Query: 773 XVXIXCXIXAI 805
I I +
Sbjct: 269 AAVIDVGINRV 279
Score = 60.5 bits (140), Expect = 8e-09
Identities = 34/84 (40%), Positives = 50/84 (59%)
Frame = +1
Query: 190 PRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVH 369
P L+++ VG S+ Y+ K +AA +GI +E I P +E ELL I LN +V
Sbjct: 68 PHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVD 127
Query: 370 GIIVQMPLDSDHAIDAHRVXDAVS 441
G++VQ+PL +H ID R+ +AVS
Sbjct: 128 GLLVQLPL-PEH-IDERRICNAVS 149
>BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 248
Score = 64.9 bits (151), Expect = 4e-10
Identities = 45/131 (34%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
PDKDVDG IN GR+ + S +P TP G E+IK+TG+ G NVV RS VG P
Sbjct: 48 PDKDVDGFHVINVGRMCLDQYS-MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMP 106
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWIXPX 772
++ LL + ATV + T L + T A ++ A G P ++ I
Sbjct: 107 IAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG 166
Query: 773 XVXIXCXIXAI 805
I I +
Sbjct: 167 AAVIDVGINRV 177
Score = 37.1 bits (82), Expect = 0.082
Identities = 21/47 (44%), Positives = 29/47 (61%)
Frame = +1
Query: 301 PRDXTEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVXDAVS 441
P +E ELL I LN +V G++VQ+PL +H ID R+ +AVS
Sbjct: 3 PASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVS 47
>BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2, precursor protein.
Length = 344
Score = 64.9 bits (151), Expect = 4e-10
Identities = 45/131 (34%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
PDKDVDG IN GR+ + S +P TP G E+IK+TG+ G NVV RS VG P
Sbjct: 144 PDKDVDGFHVINVGRMCLDQYS-MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMP 202
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWIXPX 772
++ LL + ATV + T L + T A ++ A G P ++ I
Sbjct: 203 IAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG 262
Query: 773 XVXIXCXIXAI 805
I I +
Sbjct: 263 AAVIDVGINRV 273
Score = 60.5 bits (140), Expect = 8e-09
Identities = 34/84 (40%), Positives = 50/84 (59%)
Frame = +1
Query: 190 PRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVH 369
P L+++ VG S+ Y+ K +AA +GI +E I P +E ELL I LN +V
Sbjct: 62 PHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVD 121
Query: 370 GIIVQMPLDSDHAIDAHRVXDAVS 441
G++VQ+PL +H ID R+ +AVS
Sbjct: 122 GLLVQLPL-PEH-IDERRICNAVS 143
>AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 64.9 bits (151), Expect = 4e-10
Identities = 45/131 (34%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
PDKDVDG IN GR+ + S +P TP G E+IK+TG+ G NVV RS VG P
Sbjct: 144 PDKDVDGFHVINVGRMCLDQYS-MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMP 202
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWIXPX 772
++ LL + ATV + T L + T A ++ A G P ++ I
Sbjct: 203 IAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG 262
Query: 773 XVXIXCXIXAI 805
I I +
Sbjct: 263 AAVIDVGINRV 273
Score = 58.8 bits (136), Expect = 2e-08
Identities = 34/84 (40%), Positives = 49/84 (58%)
Frame = +1
Query: 190 PRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVH 369
P L+++ VG S+ Y+ K +AA GI +E I P +E ELL I LN +V
Sbjct: 62 PHLSVILVGENPASHSYVLNKTRAAAVAGINSETIMKPASISEEELLNLINKLNNDDNVD 121
Query: 370 GIIVQMPLDSDHAIDAHRVXDAVS 441
G++VQ+PL +H ID R+ +AVS
Sbjct: 122 GLLVQLPL-PEH-IDERRICNAVS 143
>AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 64.9 bits (151), Expect = 4e-10
Identities = 45/131 (34%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
PDKDVDG IN GR+ + S +P TP G E+IK+TG+ G NVV RS VG P
Sbjct: 144 PDKDVDGFHVINVGRMCLDQYS-MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMP 202
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWIXPX 772
++ LL + ATV + T L + T A ++ A G P ++ I
Sbjct: 203 IAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG 262
Query: 773 XVXIXCXIXAI 805
I I +
Sbjct: 263 AAVIDVGINRV 273
Score = 58.8 bits (136), Expect = 2e-08
Identities = 33/84 (39%), Positives = 49/84 (58%)
Frame = +1
Query: 190 PRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVH 369
P L+++ G S+ Y+ K +AA +GI +E I P +E ELL I LN +V
Sbjct: 62 PHLSVILAGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVD 121
Query: 370 GIIVQMPLDSDHAIDAHRVXDAVS 441
G++VQ+PL +H ID R+ +AVS
Sbjct: 122 GLLVQLPL-PEH-IDERRICNAVS 143
>AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein.
Length = 344
Score = 64.9 bits (151), Expect = 4e-10
Identities = 45/131 (34%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
PDKDVDG IN GR+ + S +P TP G E+IK+TG+ G NVV RS VG P
Sbjct: 144 PDKDVDGFHVINVGRMCLDQYS-MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMP 202
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWIXPX 772
++ LL + ATV + T L + T A ++ A G P ++ I
Sbjct: 203 IAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG 262
Query: 773 XVXIXCXIXAI 805
I I +
Sbjct: 263 AAVIDVGINRV 273
Score = 60.5 bits (140), Expect = 8e-09
Identities = 34/84 (40%), Positives = 50/84 (59%)
Frame = +1
Query: 190 PRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVH 369
P L+++ VG S+ Y+ K +AA +GI +E I P +E ELL I LN +V
Sbjct: 62 PHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVD 121
Query: 370 GIIVQMPLDSDHAIDAHRVXDAVS 441
G++VQ+PL +H ID R+ +AVS
Sbjct: 122 GLLVQLPL-PEH-IDERRICNAVS 143
>BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein.
Length = 106
Score = 62.9 bits (146), Expect = 1e-09
Identities = 30/68 (44%), Positives = 43/68 (63%)
Frame = +1
Query: 190 PRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVH 369
P L+I+ VG S+ Y+R K++AA +GI +E I P+D ++ ELL LN P V
Sbjct: 24 PHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVS 83
Query: 370 GIIVQMPL 393
GI+VQ+PL
Sbjct: 84 GILVQLPL 91
>AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15).
protein.
Length = 236
Score = 60.1 bits (139), Expect = 1e-08
Identities = 41/117 (35%), Positives = 57/117 (48%), Gaps = 10/117 (8%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
P+KDVDG IN GR+ + D IP T + E+IK+TG+ G NVV RS VG P
Sbjct: 53 PEKDVDGFHIINIGRLCL-DQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMP 111
Query: 623 VSELLKWE--------PATVXVCXSXT--XXLSEXTXTAXXLVVAIGRPXMVRGSWI 763
++ LL + ATV + T L T A ++VA G P ++ +
Sbjct: 112 IAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMV 168
>BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein.
Length = 146
Score = 57.2 bits (132), Expect = 7e-08
Identities = 30/65 (46%), Positives = 39/65 (60%)
Frame = +2
Query: 443 PDKDVDGLXTINEGRVAVGDLSGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVGTP 622
P+KDVDG IN GR+ + D IP T + E+IK+TG+ G NVV RS VG P
Sbjct: 29 PEKDVDGFHIINIGRLCL-DQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMP 87
Query: 623 VSELL 637
++ LL
Sbjct: 88 IAMLL 92
>BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein.
Length = 900
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 18 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 74
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 75 VHGLALQI 82
Score = 48.8 bits (111), Expect = 3e-05
Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVG 616
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++ + +
Sbjct: 96 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLE 155
Query: 617 TPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCXI 796
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 156 AALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSH 215
Query: 797 XAIXGSSXXXRP 832
+ G P
Sbjct: 216 DFLSGKVGCGSP 227
>AY374131-1|AAQ82697.1| 275|Homo sapiens truncated
C1-tetrahydrofolate synthase protein.
Length = 275
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 96 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 152
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 153 VHGLALQI 160
Score = 40.3 bits (90), Expect = 0.009
Identities = 18/51 (35%), Positives = 31/51 (60%), Gaps = 1/51 (1%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVV 589
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++
Sbjct: 174 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKIL 224
>AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate
synthase protein.
Length = 978
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 96 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 152
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 153 VHGLALQI 160
Score = 48.8 bits (111), Expect = 3e-05
Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVG 616
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++ + +
Sbjct: 174 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLE 233
Query: 617 TPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCXI 796
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 234 AALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSH 293
Query: 797 XAIXGSSXXXRP 832
+ G P
Sbjct: 294 DFLSGKVGCGSP 305
>AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 96 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 152
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 153 VHGLALQI 160
Score = 48.8 bits (111), Expect = 3e-05
Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVG 616
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++ + +
Sbjct: 174 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLE 233
Query: 617 TPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCXI 796
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 234 AALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSH 293
Query: 797 XAIXGSSXXXRP 832
+ G P
Sbjct: 294 DFLSGKVGCGSP 305
>AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein
protein.
Length = 917
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 35 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 91
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 92 VHGLALQI 99
Score = 48.8 bits (111), Expect = 3e-05
Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVG 616
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++ + +
Sbjct: 113 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLE 172
Query: 617 TPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCXI 796
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 173 AALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSH 232
Query: 797 XAIXGSSXXXRP 832
+ G P
Sbjct: 233 DFLSGKVGCGSP 244
>AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 55 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 111
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 112 VHGLALQI 119
Score = 44.4 bits (100), Expect = 5e-04
Identities = 30/133 (22%), Positives = 56/133 (42%), Gaps = 2/133 (1%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKT-GVXIAGXNVVXLXRSXIV 613
+P+KDVDG+ IN G++ GD F+ +EL++K+ GV + G ++ + +
Sbjct: 133 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGVNLDGKKILVVGAHGSL 192
Query: 614 GTPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCX 793
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 193 EAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCS 252
Query: 794 IXAIXGSSXXXRP 832
+ G P
Sbjct: 253 HDFLSGKVGCGSP 265
>AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 96 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 152
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 153 VHGLALQI 160
Score = 48.8 bits (111), Expect = 3e-05
Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVG 616
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++ + +
Sbjct: 174 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLE 233
Query: 617 TPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCXI 796
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 234 AALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSH 293
Query: 797 XAIXGSSXXXRP 832
+ G P
Sbjct: 294 DFLSGKVGCGSP 305
>AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 55 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 111
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 112 VHGLALQI 119
Score = 44.4 bits (100), Expect = 5e-04
Identities = 30/133 (22%), Positives = 56/133 (42%), Gaps = 2/133 (1%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKT-GVXIAGXNVVXLXRSXIV 613
+P+KDVDG+ IN G++ GD F+ +EL++K+ GV + G ++ + +
Sbjct: 133 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGVNLDGKKILVVGAHGSL 192
Query: 614 GTPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCX 793
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 193 EAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCS 252
Query: 794 IXAIXGSSXXXRP 832
+ G P
Sbjct: 253 HDFLSGKVGCGSP 265
>AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 96 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 152
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 153 VHGLALQI 160
Score = 48.8 bits (111), Expect = 3e-05
Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVG 616
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++ + +
Sbjct: 174 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLE 233
Query: 617 TPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCXI 796
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 234 AALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSH 293
Query: 797 XAIXGSSXXXRP 832
+ G P
Sbjct: 294 DFLSGKVGCGSP 305
>AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial
C1-tetrahydrofolate synthetase protein.
Length = 978
Score = 48.8 bits (111), Expect = 3e-05
Identities = 25/68 (36%), Positives = 39/68 (57%)
Frame = +1
Query: 184 FEPRLAIVQVGGREXSNVYIRMKLKAAEKIGIAAEHIRLPRDXTEIELLAKITSLNESPS 363
F+P LAI+Q G N+ + AE+ G+ HI LP D +E E++ +I +NE
Sbjct: 96 FKPVLAIIQAGD---DNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTR 152
Query: 364 VHGIIVQM 387
VHG+ +Q+
Sbjct: 153 VHGLALQI 160
Score = 48.8 bits (111), Expect = 3e-05
Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVVXLXRSXIVG 616
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++ + +
Sbjct: 174 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLE 233
Query: 617 TPVSELLKWEPATVXVCXSXTXXLSEXTXTAXXLVVAIGRPXMVRGSWIXPXXVXIXCXI 796
+ L + + + T L A +V+ +P + +WI P + C
Sbjct: 234 AALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSH 293
Query: 797 XAIXGSSXXXRP 832
+ G P
Sbjct: 294 DFLSGKVGCGSP 305
>AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 114
Score = 40.3 bits (90), Expect = 0.009
Identities = 18/51 (35%), Positives = 31/51 (60%), Gaps = 1/51 (1%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVV 589
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++
Sbjct: 64 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKIL 114
Score = 39.9 bits (89), Expect = 0.012
Identities = 17/42 (40%), Positives = 27/42 (64%)
Frame = +1
Query: 262 AEKIGIAAEHIRLPRDXTEIELLAKITSLNESPSVHGIIVQM 387
AE+ G+ HI LP D +E E++ +I +NE VHG+ +Q+
Sbjct: 9 AEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQI 50
>AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 40.3 bits (90), Expect = 0.009
Identities = 18/51 (35%), Positives = 31/51 (60%), Gaps = 1/51 (1%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKTGVXIAGXNVV 589
+P+KDVDG+ IN G++ GD F+ +EL++K+GV + G ++
Sbjct: 19 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKIL 69
>AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 35.9 bits (79), Expect = 0.19
Identities = 18/52 (34%), Positives = 31/52 (59%), Gaps = 2/52 (3%)
Frame = +2
Query: 440 RPDKDVDGLXTINEGRVAVGDL-SGFIPXTPAGCVELIKKT-GVXIAGXNVV 589
+P+KDVDG+ IN G++ GD F+ +EL++K+ GV + G ++
Sbjct: 18 KPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGVNLDGKKIL 69
>AB028945-1|BAA82974.1| 1131|Homo sapiens KIAA1022 protein protein.
Length = 1131
Score = 33.1 bits (72), Expect = 1.3
Identities = 14/35 (40%), Positives = 24/35 (68%)
Frame = -2
Query: 513 NPDRSPTATRPSLIVXKPSTSLSGRDSIXDSMSVD 409
+P+++ + P++IV +PSTS SG+ S SM +D
Sbjct: 304 SPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEID 338
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 84,355,823
Number of Sequences: 237096
Number of extensions: 1308361
Number of successful extensions: 2061
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 1973
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2039
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10928473528
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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