Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP18_F_C08
(861 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 340 5e-93
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 340 5e-93
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 340 5e-93
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 340 5e-93
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 340 5e-93
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 339 8e-93
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 338 1e-92
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 338 2e-92
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 336 4e-92
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 319 7e-87
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 319 7e-87
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 319 7e-87
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 319 7e-87
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 312 1e-84
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 284 2e-76
U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic NADP-d... 186 7e-47
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 340 bits (835), Expect = 5e-93
Identities = 156/217 (71%), Positives = 184/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 340 bits (835), Expect = 5e-93
Identities = 156/217 (71%), Positives = 184/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 340 bits (835), Expect = 5e-93
Identities = 156/217 (71%), Positives = 184/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 340 bits (835), Expect = 5e-93
Identities = 156/217 (71%), Positives = 184/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 340 bits (835), Expect = 5e-93
Identities = 156/217 (71%), Positives = 184/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 339 bits (833), Expect = 8e-93
Identities = 155/217 (71%), Positives = 185/217 (85%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI+P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW +PIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVEPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 338 bits (832), Expect = 1e-92
Identities = 155/217 (71%), Positives = 184/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +E+ + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 338 bits (830), Expect = 2e-92
Identities = 156/217 (71%), Positives = 183/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEYK-GAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNSEGGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL KYDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYD 232
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 336 bits (827), Expect = 4e-92
Identities = 155/217 (71%), Positives = 183/217 (84%), Gaps = 2/217 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCAT
Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCAT 75
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+
Sbjct: 76 ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAY 135
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHS 715
DQY+ATDFVVPG G +EI + P G + + ++VH + +G GV + M+ D SI DFAHS
Sbjct: 136 GDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195
Query: 716 SFKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
SF+ AL + +PLYL T NTIL YDGRF D FQ+IYD
Sbjct: 196 SFQMALSKGWPLYLSTKNTILKIYDGRFKDIFQEIYD 232
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 319 bits (784), Expect = 7e-87
Identities = 146/216 (67%), Positives = 171/216 (79%), Gaps = 1/216 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +KY+V +KCAT
Sbjct: 56 DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCAT 115
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH
Sbjct: 116 ITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAH 175
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAGVXLAMFXTDASIIDFAHSS 718
DQYKATDFV AGT +++F P+ G +K V+ + GV + M+ TD SI FAHS
Sbjct: 176 GDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC 235
Query: 719 FKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
F++A+ +K+PLY+ T NTIL YDGRF D FQ+I+D
Sbjct: 236 FQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 319 bits (784), Expect = 7e-87
Identities = 146/216 (67%), Positives = 171/216 (79%), Gaps = 1/216 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +KY+V +KCAT
Sbjct: 56 DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCAT 115
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH
Sbjct: 116 ITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAH 175
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAGVXLAMFXTDASIIDFAHSS 718
DQYKATDFV AGT +++F P+ G +K V+ + GV + M+ TD SI FAHS
Sbjct: 176 GDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC 235
Query: 719 FKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
F++A+ +K+PLY+ T NTIL YDGRF D FQ+I+D
Sbjct: 236 FQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 319 bits (784), Expect = 7e-87
Identities = 146/216 (67%), Positives = 171/216 (79%), Gaps = 1/216 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +KY+V +KCAT
Sbjct: 56 DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCAT 115
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH
Sbjct: 116 ITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAH 175
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAGVXLAMFXTDASIIDFAHSS 718
DQYKATDFV AGT +++F P+ G +K V+ + GV + M+ TD SI FAHS
Sbjct: 176 GDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC 235
Query: 719 FKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
F++A+ +K+PLY+ T NTIL YDGRF D FQ+I+D
Sbjct: 236 FQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 319 bits (784), Expect = 7e-87
Identities = 146/216 (67%), Positives = 171/216 (79%), Gaps = 1/216 (0%)
Frame = +2
Query: 182 DEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 361
DEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +KY+V +KCAT
Sbjct: 56 DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCAT 115
Query: 362 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 541
ITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH
Sbjct: 116 ITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAH 175
Query: 542 ADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAGVXLAMFXTDASIIDFAHSS 718
DQYKATDFV AGT +++F P+ G +K V+ + GV + M+ TD SI FAHS
Sbjct: 176 GDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC 235
Query: 719 FKFALDRKYPLYLXTXNTILXKYDGRFXDXFQDIYD 826
F++A+ +K+PLY+ T NTIL YDGRF D FQ+I+D
Sbjct: 236 FQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 312 bits (765), Expect = 1e-84
Identities = 143/203 (70%), Positives = 170/203 (83%), Gaps = 2/203 (0%)
Frame = +2
Query: 224 LILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLK 403
LI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCATITPDEKRVEEFKLK
Sbjct: 1 LIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLK 60
Query: 404 KMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGA 583
+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG
Sbjct: 61 QMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGP 120
Query: 584 GTLEIIFKPESG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHSSFKFALDRKYPLYL 757
G +EI + P G + + ++VH + +G GV + M+ D SI DFAHSSF+ AL + +PLYL
Sbjct: 121 GKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYL 180
Query: 758 XTXNTILXKYDGRFXDXFQDIYD 826
T NTIL KYDGRF D FQ+IYD
Sbjct: 181 STKNTILKKYDGRFKDIFQEIYD 203
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 284 bits (697), Expect = 2e-76
Identities = 129/197 (65%), Positives = 154/197 (78%), Gaps = 1/197 (0%)
Frame = +2
Query: 239 LDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKS 418
LD++L +DLG+ NRD+TDDQVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKS
Sbjct: 42 LDVQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS 101
Query: 419 PNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEI 598
PNGTIRNI GGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDFV AGT ++
Sbjct: 102 PNGTIRNIHGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKM 161
Query: 599 IFKPESGEAIKH-VVHEYKGAGVXLAMFXTDASIIDFAHSSFKFALDRKYPLYLXTXNTI 775
+F P+ G +K V+ + GV + M+ TD SI FAHS F++A+ +K+PLY+ T NTI
Sbjct: 162 VFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTI 221
Query: 776 LXKYDGRFXDXFQDIYD 826
L YDGRF D FQ+I+D
Sbjct: 222 LKAYDGRFKDIFQEIFD 238
>U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic
NADP-dependent isocitrate dehydrogenase protein.
Length = 154
Score = 186 bits (454), Expect = 7e-47
Identities = 87/133 (65%), Positives = 104/133 (78%), Gaps = 2/133 (1%)
Frame = +2
Query: 434 RNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPE 613
RNILGGTVF EAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P
Sbjct: 1 RNILGGTVFXEAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS 60
Query: 614 SG-EAIKHVVHEY-KGAGVXLAMFXTDASIIDFAHSSFKFALDRKYPLYLXTXNTILXKY 787
G + + ++VH + +G GV + M+ D SI DFAHSSF+ AL + +PLYL T NTIL KY
Sbjct: 61 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY 120
Query: 788 DGRFXDXFQDIYD 826
DGRF D FQ+IYD
Sbjct: 121 DGRFKDIFQEIYD 133
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 110,484,439
Number of Sequences: 237096
Number of extensions: 2311991
Number of successful extensions: 3842
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 3710
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3822
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10984231046
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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