Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP17_F_I23
(875 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 242 1e-63
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 242 1e-63
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 242 1e-63
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 242 1e-63
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 242 1e-63
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 242 1e-63
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 241 2e-63
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 241 3e-63
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 240 4e-63
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 239 9e-63
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 223 9e-58
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 223 9e-58
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 223 9e-58
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 223 9e-58
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 223 9e-58
U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic NADP-d... 215 1e-55
BC020198-1|AAH20198.1| 567|Homo sapiens MEGF10 protein protein. 30 9.6
AB058676-1|BAB47409.1| 1140|Homo sapiens MEGF10 protein (KIAA178... 30 9.6
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 242 bits (593), Expect = 1e-63
Identities = 110/159 (69%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 82 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 141
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 142 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 201
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 202 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 240
Score = 147 bits (356), Expect = 5e-35
Identities = 65/80 (81%), Positives = 75/80 (93%)
Frame = +3
Query: 159 LILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLK 338
LI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCATITPDEKRVEEFKLK
Sbjct: 1 LIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLK 60
Query: 339 KMWKSPNGTIRNILGGTVFR 398
+MWKSPNGTIRNILGGTVFR
Sbjct: 61 QMWKSPNGTIRNILGGTVFR 80
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 242 bits (593), Expect = 1e-63
Identities = 110/159 (69%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 242 bits (593), Expect = 1e-63
Identities = 110/159 (69%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 242 bits (593), Expect = 1e-63
Identities = 110/159 (69%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 242 bits (593), Expect = 1e-63
Identities = 110/159 (69%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 242 bits (593), Expect = 1e-63
Identities = 110/159 (69%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 241 bits (590), Expect = 2e-63
Identities = 109/159 (68%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +E+ + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 241 bits (589), Expect = 3e-63
Identities = 109/159 (68%), Positives = 130/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW +PIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (444), Expect = 1e-45
Identities = 82/106 (77%), Positives = 96/106 (90%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI+P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 240 bits (588), Expect = 4e-63
Identities = 110/159 (69%), Positives = 129/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYKGAG-VALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
+G G VA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 171 NSEGGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 239 bits (585), Expect = 9e-63
Identities = 109/159 (68%), Positives = 129/159 (81%), Gaps = 2/159 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 111 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 170
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILK YDGRFKDIFQ+I
Sbjct: 171 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKIYDGRFKDIFQEI 230
Query: 757 YDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
YD++Y QFE IWYEHRLIDDMVA AMKS GG +WAC
Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWAC 269
Score = 182 bits (442), Expect = 2e-45
Identities = 82/106 (77%), Positives = 95/106 (89%)
Frame = +3
Query: 81 KIKAGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 260
KI G VV++ G EM RIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 261 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFR
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFR 109
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 223 bits (544), Expect = 9e-58
Identities = 98/157 (62%), Positives = 118/157 (75%), Gaps = 1/157 (0%)
Frame = +1
Query: 406 IICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHE 582
IICKNIPRLV GW KPI IGRHAH DQYKATDFV AGT +++F P+ G +K V+
Sbjct: 152 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 211
Query: 583 YKGAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDIYD 762
+ GV + M+NTD SI FAHS F++A+ + +PLY+STKNTILK YDGRFKDIFQ+I+D
Sbjct: 212 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
Query: 763 REYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
+ Y F+ IWYEHRLIDDMVA +KS GG VWAC
Sbjct: 272 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Score = 170 bits (414), Expect = 5e-42
Identities = 82/115 (71%), Positives = 93/115 (80%), Gaps = 1/115 (0%)
Frame = +3
Query: 57 PXTXYNXSKIK-AGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDD 233
P Y +IK A PVV++ G EM RIIW IKEKLILP +DI+L +DLG+ NRD+TDD
Sbjct: 35 PRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDD 94
Query: 234 QVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
QVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFR
Sbjct: 95 QVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFR 149
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 223 bits (544), Expect = 9e-58
Identities = 98/157 (62%), Positives = 118/157 (75%), Gaps = 1/157 (0%)
Frame = +1
Query: 406 IICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHE 582
IICKNIPRLV GW KPI IGRHAH DQYKATDFV AGT +++F P+ G +K V+
Sbjct: 119 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 178
Query: 583 YKGAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDIYD 762
+ GV + M+NTD SI FAHS F++A+ + +PLY+STKNTILK YDGRFKDIFQ+I+D
Sbjct: 179 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 238
Query: 763 REYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
+ Y F+ IWYEHRLIDDMVA +KS GG VWAC
Sbjct: 239 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 275
Score = 128 bits (310), Expect = 2e-29
Identities = 58/75 (77%), Positives = 66/75 (88%)
Frame = +3
Query: 174 LDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKS 353
LD++L +DLG+ NRD+TDDQVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKS
Sbjct: 42 LDVQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS 101
Query: 354 PNGTIRNILGGTVFR 398
PNGTIRNI GGTVFR
Sbjct: 102 PNGTIRNIHGGTVFR 116
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 223 bits (544), Expect = 9e-58
Identities = 98/157 (62%), Positives = 118/157 (75%), Gaps = 1/157 (0%)
Frame = +1
Query: 406 IICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHE 582
IICKNIPRLV GW KPI IGRHAH DQYKATDFV AGT +++F P+ G +K V+
Sbjct: 152 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 211
Query: 583 YKGAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDIYD 762
+ GV + M+NTD SI FAHS F++A+ + +PLY+STKNTILK YDGRFKDIFQ+I+D
Sbjct: 212 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
Query: 763 REYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
+ Y F+ IWYEHRLIDDMVA +KS GG VWAC
Sbjct: 272 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Score = 170 bits (414), Expect = 5e-42
Identities = 82/115 (71%), Positives = 93/115 (80%), Gaps = 1/115 (0%)
Frame = +3
Query: 57 PXTXYNXSKIK-AGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDD 233
P Y +IK A PVV++ G EM RIIW IKEKLILP +DI+L +DLG+ NRD+TDD
Sbjct: 35 PRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDD 94
Query: 234 QVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
QVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFR
Sbjct: 95 QVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFR 149
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 223 bits (544), Expect = 9e-58
Identities = 98/157 (62%), Positives = 118/157 (75%), Gaps = 1/157 (0%)
Frame = +1
Query: 406 IICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHE 582
IICKNIPRLV GW KPI IGRHAH DQYKATDFV AGT +++F P+ G +K V+
Sbjct: 152 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 211
Query: 583 YKGAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDIYD 762
+ GV + M+NTD SI FAHS F++A+ + +PLY+STKNTILK YDGRFKDIFQ+I+D
Sbjct: 212 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
Query: 763 REYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
+ Y F+ IWYEHRLIDDMVA +KS GG VWAC
Sbjct: 272 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Score = 170 bits (414), Expect = 5e-42
Identities = 82/115 (71%), Positives = 93/115 (80%), Gaps = 1/115 (0%)
Frame = +3
Query: 57 PXTXYNXSKIK-AGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDD 233
P Y +IK A PVV++ G EM RIIW IKEKLILP +DI+L +DLG+ NRD+TDD
Sbjct: 35 PRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDD 94
Query: 234 QVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
QVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFR
Sbjct: 95 QVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFR 149
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 223 bits (544), Expect = 9e-58
Identities = 98/157 (62%), Positives = 118/157 (75%), Gaps = 1/157 (0%)
Frame = +1
Query: 406 IICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHE 582
IICKNIPRLV GW KPI IGRHAH DQYKATDFV AGT +++F P+ G +K V+
Sbjct: 152 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 211
Query: 583 YKGAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDIYD 762
+ GV + M+NTD SI FAHS F++A+ + +PLY+STKNTILK YDGRFKDIFQ+I+D
Sbjct: 212 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271
Query: 763 REYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGXVWAC 873
+ Y F+ IWYEHRLIDDMVA +KS GG VWAC
Sbjct: 272 KHYETDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Score = 170 bits (414), Expect = 5e-42
Identities = 82/115 (71%), Positives = 93/115 (80%), Gaps = 1/115 (0%)
Frame = +3
Query: 57 PXTXYNXSKIK-AGPVVDILGXEMXRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDD 233
P Y +IK A PVV++ G EM RIIW IKEKLILP +DI+L +DLG+ NRD+TDD
Sbjct: 35 PRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDD 94
Query: 234 QVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 398
QVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFR
Sbjct: 95 QVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFR 149
>U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic
NADP-dependent isocitrate dehydrogenase protein.
Length = 154
Score = 215 bits (526), Expect = 1e-55
Identities = 98/143 (68%), Positives = 117/143 (81%), Gaps = 2/143 (1%)
Frame = +1
Query: 403 AIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVVH 579
AIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P G + + ++VH
Sbjct: 12 AIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH 71
Query: 580 EYK-GAGVALAMFNTDASIIDFAHSSFKFALDRXYPLYLSTKNTILKKYDGRFKDIFQDI 756
++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+I
Sbjct: 72 NFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEI 131
Query: 757 YDREYXKQFEDAGIWYEHRLIDD 825
YD++Y QFE IWYEHRLIDD
Sbjct: 132 YDKQYKSQFEAQKIWYEHRLIDD 154
>BC020198-1|AAH20198.1| 567|Homo sapiens MEGF10 protein protein.
Length = 567
Score = 30.3 bits (65), Expect = 9.6
Identities = 21/68 (30%), Positives = 24/68 (35%), Gaps = 3/68 (4%)
Frame = +3
Query: 432 CNRVGQTHHHWTSCSC*SIQSN*LC---CPRCWYS*NNLQT*IW*GNKTCSS*VQGCRCS 602
C G HH CSC S +C CP + N Q TC + C CS
Sbjct: 240 CQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCS 299
Query: 603 TGYV*H*C 626
GY C
Sbjct: 300 PGYTGERC 307
>AB058676-1|BAB47409.1| 1140|Homo sapiens MEGF10 protein (KIAA1780)
protein.
Length = 1140
Score = 30.3 bits (65), Expect = 9.6
Identities = 21/68 (30%), Positives = 24/68 (35%), Gaps = 3/68 (4%)
Frame = +3
Query: 432 CNRVGQTHHHWTSCSC*SIQSN*LC---CPRCWYS*NNLQT*IW*GNKTCSS*VQGCRCS 602
C G HH CSC S +C CP + N Q TC + C CS
Sbjct: 240 CQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCS 299
Query: 603 TGYV*H*C 626
GY C
Sbjct: 300 PGYTGERC 307
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 113,159,823
Number of Sequences: 237096
Number of extensions: 2321426
Number of successful extensions: 4164
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 3981
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4142
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 11159604822
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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