Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP16_F_F10
(890 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 162 1e-38
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 144 2e-33
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 132 1e-29
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 101 3e-20
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 100 1e-19
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 82 2e-14
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 81 5e-14
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 80 9e-14
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 78 3e-13
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 77 5e-13
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 77 5e-13
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 77 6e-13
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 74 6e-12
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 74 6e-12
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 73 1e-11
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 71 3e-11
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 71 5e-11
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 69 2e-10
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 69 2e-10
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 68 3e-10
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 68 3e-10
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 68 4e-10
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 68 4e-10
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 67 6e-10
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 66 9e-10
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 65 2e-09
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 64 5e-09
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 64 5e-09
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 64 5e-09
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 64 6e-09
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 63 8e-09
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 63 1e-08
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 62 2e-08
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 61 3e-08
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 61 4e-08
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 61 4e-08
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 61 4e-08
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 60 6e-08
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 60 6e-08
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 60 7e-08
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 60 1e-07
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 59 1e-07
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 59 1e-07
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 58 2e-07
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 58 2e-07
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 58 2e-07
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 58 2e-07
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 58 3e-07
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 58 4e-07
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 56 1e-06
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 56 1e-06
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 56 1e-06
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 56 1e-06
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 56 2e-06
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 55 2e-06
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 55 3e-06
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 54 5e-06
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 53 9e-06
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 53 9e-06
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 53 9e-06
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 52 2e-05
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 52 3e-05
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 52 3e-05
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 51 5e-05
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 50 6e-05
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 50 6e-05
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 50 8e-05
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 50 1e-04
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 49 2e-04
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 48 3e-04
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 47 7e-04
UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1; Trepo... 46 0.002
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 45 0.002
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 44 0.004
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 44 0.007
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 44 0.007
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 44 0.007
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 42 0.028
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 37 0.60
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 37 0.79
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 36 1.0
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 36 1.4
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 36 1.4
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 34 4.2
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 33 7.4
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 162 bits (393), Expect = 1e-38
Identities = 80/142 (56%), Positives = 96/142 (67%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A+IISG VA SI +LR +VT + + + F P L IVQVGGREDSNVY
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
H++LPR ITE+ELL KI LNE P VHGIIVQMPLD D ID+HR+TDAVSP+K
Sbjct: 64 GIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKD 123
Query: 452 VDXLNTINEGXXAVXDLSXFIP 517
VD L+T+NEG A+ DL F+P
Sbjct: 124 VDGLHTVNEGRLAIGDLGGFLP 145
Score = 38.7 bits (86), Expect = 0.20
Identities = 19/35 (54%), Positives = 22/35 (62%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVS 627
TP GC+ELI+ + I VVL RS IVGTP S
Sbjct: 147 TPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAS 181
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 144 bits (350), Expect = 2e-33
Identities = 79/196 (40%), Positives = 104/196 (53%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
++SG ++A I L + V ++ K + P LAIVQVGGREDSNVY
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
H+++P TE ELL K+ LN P HGIIVQMPLDS + I++H +TD VSPDK VD
Sbjct: 69 KATHVKMPNTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVD 128
Query: 458 XLNTINEGXXAVXDLSXFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQSCX 637
LNTINEG A+ D+S F+P G ++ G +
Sbjct: 129 GLNTINEGRVAIGDMSGFLP-CTPNGCIELIKRSGVPIAGAQAVVLGRSKIVGTPVAELL 187
Query: 638 NXNTPTVTVCHSKTKN 685
+ TVTVCHS+TK+
Sbjct: 188 KWHNATVTVCHSRTKD 203
Score = 50.0 bits (114), Expect = 8e-05
Identities = 27/50 (54%), Positives = 31/50 (62%), Gaps = 3/50 (6%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
TP GC+ELIK + I VVL RS IVGTPV+ELLK + CHS
Sbjct: 150 TPNGCIELIKRSGVPIAGAQAVVLGRSKIVGTPVAELLKWHNATVTVCHS 199
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 132 bits (319), Expect = 1e-29
Identities = 76/197 (38%), Positives = 108/197 (54%), Gaps = 1/197 (0%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+Y
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
HI+LPR TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+K
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 452 VDXLNTINEGXXAVXDLS-XFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQ 628
VD L +IN G A DL+ FIP G ++ + G +
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIP-CTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMH 182
Query: 629 SCXNXNTPTVTVCHSKT 679
N TVT CHSKT
Sbjct: 183 DLLLWNNATVTTCHSKT 199
Score = 43.2 bits (97), Expect = 0.009
Identities = 20/38 (52%), Positives = 26/38 (68%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP GC+ELIK T I ++ VV+ RS IVG P+ +LL
Sbjct: 148 TPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLL 185
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 101 bits (241), Expect = 3e-20
Identities = 55/142 (38%), Positives = 76/142 (53%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
+A+I+SG+E + + +D+ Q++ + R F LAIVQVG R DSNVY
Sbjct: 2 VAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKE 61
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
I+LP IT+ +L +I +LN + GII+Q+PLD H IDA V D + P K
Sbjct: 62 IGADGKLIKLPDTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLK 121
Query: 449 XVDXLNTINEGXXAVXDLSXFI 514
VD L IN G A +L I
Sbjct: 122 DVDGLTRINAGRLARGELQRTI 143
Score = 34.3 bits (75), Expect = 4.2
Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 6/53 (11%)
Frame = +1
Query: 523 TPAGCVELIKXTXXT---IPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
TP GC+ L++ + K VVVL RS IVG+P + L H CHS
Sbjct: 147 TPFGCLYLVQQATGDANFVSGKEVVVLGRSKIVGSPAAALFLWHHGTVTICHS 199
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 99.5 bits (237), Expect = 1e-19
Identities = 67/181 (37%), Positives = 89/181 (49%), Gaps = 1/181 (0%)
Frame = +2
Query: 140 LRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEI 319
L Q++ RL S F + ++QVG R+DSN+Y H+RLP T+
Sbjct: 68 LGQKLLRLLVLTSVF--LVTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQE 125
Query: 320 ELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAVXD 499
E+L I S+NE SVHG+IVQ+PLDS H ID+ +T+ VS DK VD L+ IN G + D
Sbjct: 126 EVLLNILSINEDQSVHGLIVQLPLDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGD 185
Query: 500 L-SXFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQSCXNXNTPTVTVCHSK 676
L + F+P G +R K G + N TVT CHSK
Sbjct: 186 LDACFLP-CTPSGCLELIRQTGVSLEGKQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSK 244
Query: 677 T 679
T
Sbjct: 245 T 245
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 82.2 bits (194), Expect = 2e-14
Identities = 47/134 (35%), Positives = 73/134 (54%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A+II G +A +I +++ ++V L K G P LA+V VG R+DS Y
Sbjct: 9 AKIIDGKAIAHTIRSEIAEEVRGLSEK-HGKVPGLAVVIVGSRKDSQTYVNTKRKACAEV 67
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
+ LP +++E +L+ K+ LN +P VHGI+VQ+PL H + H + A+S DK
Sbjct: 68 GIKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPK-HINEEH-ILGAISIDKD 125
Query: 452 VDXLNTINEGXXAV 493
VD + +N G A+
Sbjct: 126 VDGFHPLNIGKLAM 139
Score = 37.9 bits (84), Expect = 0.34
Identities = 19/38 (50%), Positives = 24/38 (63%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP GC+EL+ + I + VV+ RS IVG PVS LL
Sbjct: 150 TPKGCLELLARSGVKIKGQRAVVVGRSNIVGLPVSLLL 187
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 80.6 bits (190), Expect = 5e-14
Identities = 55/162 (33%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Frame = +2
Query: 14 PSHYREFLRFRVGIGSTNETVLWAKM--AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFE 187
P R L R + S V A A +I G ++A +I +L+ +V LR++++
Sbjct: 34 PPQRRVSLTLRGSVVSAKRAVATASAMPAALIDGKKIAETIRGELKVEVDELRAQYNTV- 92
Query: 188 PRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSVH 367
P LA+V VG R+DS Y LP TE E+L + N+ P+VH
Sbjct: 93 PGLAVVLVGERKDSQTYVRSKKKACDEVGINSFGADLPETATEEEVLAVVAKFNDDPNVH 152
Query: 368 GIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAV 493
GI+VQ+PL +H I+ RV DA+S +K VD + N G A+
Sbjct: 153 GILVQLPL-PEH-INEKRVLDAISLEKDVDGFHPNNIGELAM 192
Score = 39.9 bits (89), Expect = 0.085
Identities = 19/43 (44%), Positives = 25/43 (58%)
Frame = +1
Query: 511 YSLXTPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLK 639
Y TP GC+EL+K T+ K V+ RS IVG P + LL+
Sbjct: 199 YVSCTPKGCLELLKRAGVTLAGKRAAVVGRSNIVGLPAALLLQ 241
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 79.8 bits (188), Expect = 9e-14
Identities = 46/134 (34%), Positives = 72/134 (53%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A +I G VA I +++ +V+R++ G P LA++ VG R+DS Y
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKES-IGVIPGLAVILVGDRKDSATYVRNKKKACDSV 127
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
+RL D +E E+L ++ N+ PSVHGI+VQ+PL S +D + +AVS +K
Sbjct: 128 GIKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSH--MDEQNILNAVSIEKD 185
Query: 452 VDXLNTINEGXXAV 493
VD + +N G A+
Sbjct: 186 VDGFHPLNIGRLAM 199
Score = 37.1 bits (82), Expect = 0.60
Identities = 18/39 (46%), Positives = 23/39 (58%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLK 639
TP GC+EL+ I K VV+ RS IVG P + LL+
Sbjct: 210 TPKGCIELLHRYNIEIKGKRAVVIGRSNIVGMPAALLLQ 248
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 78.2 bits (184), Expect = 3e-13
Identities = 48/135 (35%), Positives = 67/135 (49%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MA II G +A I +++ V L+ K G P LA+V VG + S VY
Sbjct: 1 MAHIIDGKAIAAKIRSEIASGVRELQGK--GVTPGLAVVLVGDDQASRVYVSMKEKACND 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
+L + +E ELL + LN P +HGI+VQ+PL S ID +V +A+SP K
Sbjct: 59 AGIFSVEHKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQ--IDTDKVLEAISPFK 116
Query: 449 XVDXLNTINEGXXAV 493
VD + N G +V
Sbjct: 117 DVDGFHPYNVGRLSV 131
Score = 33.5 bits (73), Expect = 7.4
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Frame = +1
Query: 508 IYSLXTPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
++ TP G + +++ + K VVV+ RS IVG PV+ + H CHS
Sbjct: 135 VFQPCTPYGVMVMLREAGVELKGKEVVVVGRSNIVGKPVAMMCLAEHATVTLCHS 189
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/129 (37%), Positives = 64/129 (49%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MA IISG A + DL + V R S+ G+ P L V VG S++Y
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARF-SQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRK 59
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
RLP D +E +LL I SLN VHGI+VQ+PL + ID+ +V D + P K
Sbjct: 60 VGMESVEHRLPADCSEEDLLALIASLNADERVHGILVQLPLPAQ--IDSGKVLDTIDPRK 117
Query: 449 XVDXLNTIN 475
VD + +N
Sbjct: 118 DVDGFHPVN 126
Score = 34.7 bits (76), Expect = 3.2
Identities = 16/38 (42%), Positives = 23/38 (60%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP GC+ L++ + K VV+ +S IVG PV+ LL
Sbjct: 141 TPMGCMILLRSVLPDLKGKQAVVIGKSNIVGKPVAMLL 178
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 77.4 bits (182), Expect = 5e-13
Identities = 46/131 (35%), Positives = 69/131 (52%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MAQ++ G E++ + +++++V R + + G P+LA+V VG S VY
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQ--GVNPKLAVVLVGDDPASVVYAKSKQKVSDS 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
LP D +E +L I SLN +P VHGI++++PL I RV AV PDK
Sbjct: 59 LGIDFELTVLPADSSEESILALIDSLNANPDVHGIMIELPLPKH--ISKERVMAAVRPDK 116
Query: 449 XVDXLNTINEG 481
VD ++ IN G
Sbjct: 117 DVDGVHPINRG 127
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 77.0 bits (181), Expect = 6e-13
Identities = 51/143 (35%), Positives = 68/143 (47%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
M +II G VA + + LR V RL+++ G P L +V VG S +Y
Sbjct: 1 MREIIDGKLVARGLLDRLRVSVDRLKAE-HGIVPHLVVVIVGDDPASKLYVGNKQRKAEE 59
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
I L D ++ ELL I LN +VHGI+VQ+PL ID V +A+SP+K
Sbjct: 60 LGLQSRTIALEHDTSQEELLRIIDELNRDAAVHGILVQLPL--PRHIDKELVINAISPEK 117
Query: 449 XVDXLNTINEGXXAVXDLSXFIP 517
VD + N G A L IP
Sbjct: 118 DVDGFHNANAGKLATGQLDCMIP 140
Score = 39.5 bits (88), Expect = 0.11
Identities = 19/38 (50%), Positives = 23/38 (60%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP GC+ LIK + N VV+ RS IVG PV+ LL
Sbjct: 142 TPQGCIHLIKTVKQDLAGSNAVVVGRSNIVGKPVALLL 179
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 73.7 bits (173), Expect = 6e-12
Identities = 42/132 (31%), Positives = 68/132 (51%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
I+ G +VA ++ + ++ V L+S + + P+L +++VG S +Y
Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVY-PKLVVIEVGELPQSKLYIKQKFKFAKKYGI 64
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
H+RLP I+E LL + LN SVHGI +Q+P DSD I+ +AV+ K V+
Sbjct: 65 LLSHMRLPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVE 124
Query: 458 XLNTINEGXXAV 493
LN+ N +V
Sbjct: 125 GLNSYNTALLSV 136
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 73.7 bits (173), Expect = 6e-12
Identities = 41/130 (31%), Positives = 66/130 (50%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A +I G ++ ++ ++ L ++ G P LA++ VG S VY
Sbjct: 3 ATLIDGNALSKTLRAQAAERAAALAAR--GHRPGLAVILVGDNPASEVYVRNKIKACEDN 60
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
R P ++E ELL +I LN P +HGI+VQ+PL + ID+H+V +A++P+K
Sbjct: 61 GFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAH--IDSHKVIEAIAPEKD 118
Query: 452 VDXLNTINEG 481
VD + N G
Sbjct: 119 VDGFHVANAG 128
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 72.9 bits (171), Expect = 1e-11
Identities = 46/144 (31%), Positives = 70/144 (48%)
Frame = +2
Query: 86 KMAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXX 265
+MA++I G ++A I +LR+Q+ + P L + +G SN Y
Sbjct: 31 EMAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAA 90
Query: 266 XXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPD 445
R DITE +LL +I LN+ SV GI+VQ+P+ I+ +V ++VS D
Sbjct: 91 DVGITSKTERYSADITEEQLLKRIEELNQDDSVDGILVQLPVPGH--INERKVCNSVSCD 148
Query: 446 KXVDXLNTINEGXXAVXDLSXFIP 517
K VD N N G + D++ IP
Sbjct: 149 KDVDGFNERNIGRLCL-DMNTLIP 171
Score = 34.7 bits (76), Expect = 3.2
Identities = 19/38 (50%), Positives = 22/38 (57%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP G ELIK T KN VV+ RS VG P++ LL
Sbjct: 173 TPLGVQELIKRTEIETFGKNAVVVGRSKNVGMPIAMLL 210
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 71.3 bits (167), Expect = 3e-11
Identities = 47/138 (34%), Positives = 69/138 (50%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A +ISG ++A I ++RQ+V + + P L+++ VG S+ Y
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNK-RPHLSVILVGENPASHSYVLNKTRAAAVV 95
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
I P I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDK
Sbjct: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKD 153
Query: 452 VDXLNTINEGXXAVXDLS 505
VD + IN G + S
Sbjct: 154 VDGFHVINVGRMCLDQYS 171
Score = 33.9 bits (74), Expect = 5.6
Identities = 19/38 (50%), Positives = 22/38 (57%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP G E+IK T KNVVV RS VG P++ LL
Sbjct: 176 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLL 213
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 71.3 bits (167), Expect = 3e-11
Identities = 44/131 (33%), Positives = 67/131 (51%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
+A+++ G+ V+ I L + L + +G P+LA V VG S Y
Sbjct: 2 VAKVLDGLAVSAGIFERLHRACCELEN--NGVCPKLATVLVGNNPASRSYVLSKHRDCKN 59
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
I LP + +E EL+ K+ LN S V GIIVQ+PL +ID ++V +A++PDK
Sbjct: 60 IGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPL--PESIDQNKVIEAINPDK 117
Query: 449 XVDXLNTINEG 481
D L+ +N G
Sbjct: 118 DADGLHPLNLG 128
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 71.3 bits (167), Expect = 3e-11
Identities = 45/143 (31%), Positives = 68/143 (47%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MA +++G E++ + ++ +V L+ K G P L ++ VG S Y
Sbjct: 1 MATLLNGKELSEELKQKMKIEVDELKEK--GLTPHLTVILVGDNPASKSYVKGKEKACAV 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
I LP +I++ ELL I N SVHGI+VQ+PL +D ++ A+SP K
Sbjct: 59 TGISSNLIELPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQ--MDEQKIIHAISPAK 116
Query: 449 XVDXLNTINEGXXAVXDLSXFIP 517
VD + IN G + FIP
Sbjct: 117 DVDGFHPINVGKMMTGE-DTFIP 138
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 70.5 bits (165), Expect = 5e-11
Identities = 44/129 (34%), Positives = 65/129 (50%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
+II G +A S+ +++ +V R +++ G EP LA+V VG S VY
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQ--GIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG 69
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
R D++E ELL +I LN VHGI+VQ+PL I+ RV + + P K V
Sbjct: 70 IRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQ--INETRVLERIHPQKDV 127
Query: 455 DXLNTINEG 481
D ++ N G
Sbjct: 128 DGFHSENVG 136
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 68.9 bits (161), Expect = 2e-10
Identities = 46/133 (34%), Positives = 62/133 (46%)
Frame = +2
Query: 83 AKMAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXX 262
A A + G +A SI L V +++W G P LA+++VG S VY
Sbjct: 3 AHAATCLDGKSLAQSIERQLADHVRTFQAQW-GRSPGLAVLRVGNDPASAVYVRAKEQAC 61
Query: 263 XXXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSP 442
LP ITE LL KIT LN+ V GI++Q+PL +D + A+ P
Sbjct: 62 SRVGIQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPH--LDPRPLLYAIHP 119
Query: 443 DKXVDXLNTINEG 481
DK VD L+ N G
Sbjct: 120 DKDVDGLHPENLG 132
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 68.5 bits (160), Expect = 2e-10
Identities = 44/133 (33%), Positives = 63/133 (47%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
+++ G +++G I ++ V L K G P LA V VG S Y
Sbjct: 6 KLLDGKKISGEIKQEIAAVVNELLEK-GGRRPHLAGVLVGHDGGSETYMASKVKACEEVG 64
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
IR D+TE ELL + LN+ P+V G IVQ+PL ID ++ +AV P K V
Sbjct: 65 FTSSLIRYEDDVTEEELLACVHRLNQDPTVDGFIVQLPLPKH--IDEQKIIEAVDPRKDV 122
Query: 455 DXLNTINEGXXAV 493
D + IN G ++
Sbjct: 123 DGFHPINVGRLSI 135
Score = 37.5 bits (83), Expect = 0.45
Identities = 20/38 (52%), Positives = 24/38 (63%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP G VEL++ K+ VVL RS IVG PVS+LL
Sbjct: 144 TPKGIVELLRRYNIPTRGKHCVVLGRSNIVGKPVSQLL 181
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 68.1 bits (159), Expect = 3e-10
Identities = 44/133 (33%), Positives = 61/133 (45%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A++I G A + + ++V L+++ G P LA+V VG S VY
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAE-HGVTPGLAVVLVGEDPASQVYVRNKGEQTTAA 62
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
RLP T+ ELL + LN P +HG++VQ P+ I V A+SPDK
Sbjct: 63 GMYSETHRLPETTTQDELLAVVAKLNADPKIHGVLVQFPVPPH--ISQMDVVAALSPDKD 120
Query: 452 VDXLNTINEGXXA 490
VD L N G A
Sbjct: 121 VDGLTVTNAGRLA 133
Score = 35.1 bits (77), Expect = 2.4
Identities = 14/38 (36%), Positives = 24/38 (63%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP GC+ LI+ + K VV+ RS ++G P++++L
Sbjct: 143 TPTGCMMLIRDAIGDLKGKTAVVIGRSNLMGKPMAQML 180
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 68.1 bits (159), Expect = 3e-10
Identities = 39/129 (30%), Positives = 63/129 (48%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
+IISG ++A I L+++ R G P LA++ VGG+++ Y
Sbjct: 2 EIISGSQIAQEIRQKLKEKNER-----EGISPCLAMILVGGQKEDLHYVGLKEKAATATG 56
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
+ LP D ++ EL+ KI LN+ V GI++Q+PL + + A+ PDK V
Sbjct: 57 GKSRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDV 116
Query: 455 DXLNTINEG 481
D + +N G
Sbjct: 117 DGFSLVNRG 125
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 67.7 bits (158), Expect = 4e-10
Identities = 39/128 (30%), Positives = 62/128 (48%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
+I G ++A + LRQ+V L++K + P L ++ +G S +Y
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKI-PGLTVILIGEMAPSQIYVRMKEKAANEVGL 61
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
IR P + E +L KI LN+ S+ GI+VQ+PL ID +V + + P K VD
Sbjct: 62 KSEVIRYPEAVEEKTVLDKIEELNKDESISGILVQLPLPKH--IDKQKVIETILPGKDVD 119
Query: 458 XLNTINEG 481
+ +N G
Sbjct: 120 GFHPMNVG 127
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 67.7 bits (158), Expect = 4e-10
Identities = 44/143 (30%), Positives = 65/143 (45%), Gaps = 1/143 (0%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A+IISG E+ I +++ VT ++ K+ G P L + VG S Y
Sbjct: 3 AKIISGTEIRKEILGEIKDAVTEMKDKY-GTVPGLVTILVGESPASMSYVSLKIKTALSL 61
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
L + TE ELL I N S+HG++VQ+PL I+ + A+ PDK
Sbjct: 62 GFYEVQESLSVETTEAELLALIEKYNNDDSIHGVLVQLPLPKH--INEQNIITAIDPDKD 119
Query: 452 VDXLNTINEGXXAV-XDLSXFIP 517
VD + +N G + D F+P
Sbjct: 120 VDAFHPVNIGRLMIGGDDVKFLP 142
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 66.9 bits (156), Expect = 6e-10
Identities = 41/125 (32%), Positives = 62/125 (49%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MA+++ G VA ++ +L + LR + G P LAIV+VG RED Y
Sbjct: 1 MAELLKGAPVARALTEELAARCAALREQ--GVVPMLAIVRVGEREDDLSYERGALKRCEK 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
+ LP D+++ ELL I +N P+VHG ++ PL + +D V A+ P K
Sbjct: 59 VGIEARRVLLPVDVSQDELLAAIKDINADPAVHGCLMFRPLPA--GLDEDAVAAALDPAK 116
Query: 449 XVDXL 463
VD +
Sbjct: 117 DVDSM 121
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 66.5 bits (155), Expect = 9e-10
Identities = 35/110 (31%), Positives = 52/110 (47%)
Frame = +2
Query: 188 PRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSVH 367
P LA+V +G S +Y R P D T ++L I LN ++H
Sbjct: 27 PGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKPSDATLSDILALIHQLNNDENIH 86
Query: 368 GIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAVXDLSXFIP 517
GI+VQ+PL +DA + ++PDK VD L+ +N G + + FIP
Sbjct: 87 GILVQLPLPKH--LDAQAILSTITPDKDVDGLHPVNVGKLLLGETDGFIP 134
Score = 40.7 bits (91), Expect = 0.049
Identities = 21/42 (50%), Positives = 26/42 (61%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH 648
TPAG VEL K + K+VV+L RS IVG P++ LL H
Sbjct: 136 TPAGIVELCKYYEIPLHGKHVVILGRSNIVGKPLAALLMQRH 177
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 65.3 bits (152), Expect = 2e-09
Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 1/198 (0%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
QII G VA I +L ++V L + G P+L IV+VG R D Y
Sbjct: 9 QIIKGKPVADKISEELIKEVDLLVKE--GINPKLTIVRVGARSDDLSYERGALKRCQNIG 66
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
+ L DIT+ E + + +N+ +V+GI+ PL ++ + ++P+K V
Sbjct: 67 ITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKH--LNEEVIKYVIAPEKDV 124
Query: 455 DXLNTINEGXXAVXDLSXFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQSC 634
D + IN D S F P P A + ++ L G + V + S
Sbjct: 125 DCFSPINSAKVMEGDKSGFPP--CTPTAVVEILKHYNVDLKGSKVTVLGRSMVVGKPVSM 182
Query: 635 XNXNT-PTVTVCHSKTKN 685
+ TVT+CHSKTKN
Sbjct: 183 LLLSEHATVTICHSKTKN 200
Score = 36.7 bits (81), Expect = 0.79
Identities = 21/50 (42%), Positives = 25/50 (50%), Gaps = 3/50 (6%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
TP VE++K + V VL RS +VG PVS LL H CHS
Sbjct: 147 TPTAVVEILKHYNVDLKGSKVTVLGRSMVVGKPVSMLLLSEHATVTICHS 196
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 64.1 bits (149), Expect = 5e-09
Identities = 39/133 (29%), Positives = 63/133 (47%)
Frame = +2
Query: 83 AKMAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXX 262
A+ A+I+ G A +I ++L ++V +L+++ G P +A V VG S +Y
Sbjct: 2 AQAAKILDGKAAAAAIKSELAERVAKLKAR--GVTPGIATVLVGADPASQLYVSMKHKQS 59
Query: 263 XXXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSP 442
LP D T+ ++ I LN P+ HG IVQ+PL +D + + + P
Sbjct: 60 VEIGMNSIQRELPADATQAQVEALIDELNADPACHGYIVQLPLPKH--LDTDAILERIDP 117
Query: 443 DKXVDXLNTINEG 481
K D L+ N G
Sbjct: 118 AKDADGLHPTNLG 130
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 64.1 bits (149), Expect = 5e-09
Identities = 38/131 (29%), Positives = 64/131 (48%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
+A I+ G +++ I ++ +V L++K G P LA+V VG S +Y
Sbjct: 2 LATILDGNKISAEIKTEVAAEVAELKAK--GLTPGLAVVLVGHNPASEIYVRNKVKACEM 59
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
P ++ +LL + SLN + GI+VQ+PL +D+ ++ AVSP+K
Sbjct: 60 TGIYSEQHTPPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQ--VDSKKILLAVSPEK 117
Query: 449 XVDXLNTINEG 481
VD + +N G
Sbjct: 118 DVDGFHPMNVG 128
Score = 39.5 bits (88), Expect = 0.11
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 3/50 (6%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
TPAGC+E+++ + + + VV+ RS IVG P++ LL + CHS
Sbjct: 141 TPAGCMEILRRSNVPVEGADAVVVGRSDIVGKPIAMLLTNANATVTICHS 190
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 64.1 bits (149), Expect = 5e-09
Identities = 33/131 (25%), Positives = 67/131 (51%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
M II+G ++A + + + +V +L+ + G P + ++ VG S +Y
Sbjct: 1 MTNIINGRQIAKQLNQETKTRVDKLKEE--GIIPGIVVILVGDDPASVIYTRNKQKNAEK 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
+ P+D+++ E+L I N+ P++H I++Q+PL ++ + +A++P+K
Sbjct: 59 LGMKSILRKFPKDVSQAEVLQAIHHYNDDPTIHAILIQLPLPKH--LNQTELIEAIAPEK 116
Query: 449 XVDXLNTINEG 481
VD N+ N G
Sbjct: 117 DVDGFNSKNVG 127
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 63.7 bits (148), Expect = 6e-09
Identities = 45/134 (33%), Positives = 62/134 (46%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MA I+ G VA + ++ +V L ++ LAI+ VG S +Y
Sbjct: 1 MALILDGKAVAAAYKAKIKAKVDALAAQ--NITCGLAILLVGNDAASRIYADRLVKLATG 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
LP D TE E+L + LNE +HGI+ MPL A D RV A++PDK
Sbjct: 59 LGVQAVVRHLPADATEEEVLALVCELNEDDHIHGILPMMPLPPHLATD--RVAAALAPDK 116
Query: 449 XVDXLNTINEGXXA 490
VD L+ +N G A
Sbjct: 117 DVDALHPLNAGLVA 130
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 63.3 bits (147), Expect = 8e-09
Identities = 44/140 (31%), Positives = 64/140 (45%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
II G +A I DL+ ++ + K + P+LAIV VG S +Y
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEK-TKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGI 63
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
+ L +I +L+ KI LN + GIIVQ+PL S +ID +++ AV P K D
Sbjct: 64 DTLLVNLSTNIYTDDLILKINELNLDKGISGIIVQLPLPS--SIDENKILSAVLPSKDSD 121
Query: 458 XLNTINEGXXAVXDLSXFIP 517
+ +N G FIP
Sbjct: 122 GFHPLNVGYLHSGINQGFIP 141
Score = 33.9 bits (74), Expect = 5.6
Identities = 19/50 (38%), Positives = 27/50 (54%), Gaps = 3/50 (6%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
T GC+ +IK + K+ V++ RS IVG P+S LL + CHS
Sbjct: 143 TALGCLAVIKKYAPNLNGKDAVIVGRSNIVGKPLSALLLQENCSVTICHS 192
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 62.9 bits (146), Expect = 1e-08
Identities = 33/100 (33%), Positives = 52/100 (52%)
Frame = +2
Query: 182 FEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPS 361
F P L I+QVGGR DS+ Y ++ D++E +LL +I LN+ P
Sbjct: 74 FRPNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPK 133
Query: 362 VHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEG 481
V+G+++Q+PL + +T+AV+ +K VD N G
Sbjct: 134 VNGLLIQLPLPKH--FNETLITNAVATEKDVDGFARYNVG 171
Score = 45.6 bits (103), Expect = 0.002
Identities = 22/39 (56%), Positives = 28/39 (71%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLK 639
TP G +ELIK T ++ KN VVL RS IVGTPV+ +L+
Sbjct: 186 TPNGIMELIKTTGISLRGKNAVVLGRSDIVGTPVAAMLR 224
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/130 (31%), Positives = 62/130 (47%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A+II G +A + +++ +VT+ ++ P LA+V VG S +Y
Sbjct: 3 AKIIDGKTIAQQVKDEVAARVTQRLAEGKR-APGLAVVLVGDNPASQIYVTSKRKVCEEV 61
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
LP TE ELL I LN ++ GI+VQ+PL ID +V + ++PDK
Sbjct: 62 GFISRSYDLPITTTESELLALIDQLNADQAIDGILVQLPL--PEGIDNTKVIERIAPDKD 119
Query: 452 VDXLNTINEG 481
VD + N G
Sbjct: 120 VDGFHPYNVG 129
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 61.3 bits (142), Expect = 3e-08
Identities = 41/137 (29%), Positives = 61/137 (44%), Gaps = 1/137 (0%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
++II G +A + ++R V L S G P LA + VG S +Y
Sbjct: 8 SRIIDGKVLAQQVEEEVRSGVEDLESN-RGIVPGLATILVGDDPASKMYVRLKHRACERV 66
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHA-IDAHRVTDAVSPDK 448
LP D T+ ELL I SLN++ VH I++Q+PL + + +A+SP K
Sbjct: 67 GIKAEDYLLPGDATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTK 126
Query: 449 XVDXLNTINEGXXAVXD 499
D + N G + D
Sbjct: 127 DADGFHPYNMGKLMIGD 143
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 60.9 bits (141), Expect = 4e-08
Identities = 40/132 (30%), Positives = 58/132 (43%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
I+ G VA + L +V L K G P LA + VG S Y
Sbjct: 45 ILDGKRVAADVKEGLMPRVENLTQK--GITPCLATILVGDDPSSETYVRMKGNACARLGI 102
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
I +P++ T EL+ I LNE+ VHGI++Q P+ ID + + +S DK VD
Sbjct: 103 RSERIHMPKETTTEELVKTIEELNENKEVHGILLQHPVPGH--IDERKAFETISIDKDVD 160
Query: 458 XLNTINEGXXAV 493
+ + G A+
Sbjct: 161 GVTSHGYGQTAL 172
Score = 35.9 bits (79), Expect = 1.4
Identities = 18/42 (42%), Positives = 24/42 (57%)
Frame = +1
Query: 511 YSLXTPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
Y TPA + +I + K+ VV+ RSPI+G PVS LL
Sbjct: 177 YPSCTPAAIMAIIDYYHLPVEGKHAVVVGRSPILGKPVSALL 218
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 60.9 bits (141), Expect = 4e-08
Identities = 44/130 (33%), Positives = 61/130 (46%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A++I G + A L +V LR+ G P LA V VG S Y
Sbjct: 3 ARLIDGKQAAHECTARLATRVQALRAA-VGTAPFLAAVLVGDDPASCTYVAAKQRALARA 61
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
RLP + ++L I LNE VHGI++Q+PL + +DA RV AV+P+K
Sbjct: 62 HLRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAH--LDAARVCRAVAPEKD 119
Query: 452 VDXLNTINEG 481
VD + +N G
Sbjct: 120 VDGFHPLNCG 129
Score = 33.9 bits (74), Expect = 5.6
Identities = 16/38 (42%), Positives = 23/38 (60%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TPAG V L++ + VV++ RS IVG P++ LL
Sbjct: 142 TPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLL 179
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 60.9 bits (141), Expect = 4e-08
Identities = 50/199 (25%), Positives = 82/199 (41%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
M +I+ G VA + L+++V L+ + G P ++ +G S +Y
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEE--GITPHFCVINIGDDPASKIYVRTKKRRAEK 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
+LP D + L I LNE P ++G++VQ+P + IDA + + + P+K
Sbjct: 59 MGIIQDIYQLPADTKQEVALNLIDKLNEDPDINGVMVQLP--APEQIDADELLERIDPNK 116
Query: 449 XVDXLNTINEGXXAVXDLSXFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQ 628
VD L N G + + FI G L+ L K G +
Sbjct: 117 DVDGLTPSNIG--RIWMENHFIEPATAEGIIALLKYYKILLKGKNVVVIGRSNIVGKPVA 174
Query: 629 SCXNXNTPTVTVCHSKTKN 685
+ TVT+ HS+T+N
Sbjct: 175 ALMLEQNATVTIAHSETEN 193
Score = 34.3 bits (75), Expect = 4.2
Identities = 17/38 (44%), Positives = 23/38 (60%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
T G + L+K + KNVVV+ RS IVG PV+ L+
Sbjct: 140 TAEGIIALLKYYKILLKGKNVVVIGRSNIVGKPVAALM 177
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 60.5 bits (140), Expect = 6e-08
Identities = 41/132 (31%), Positives = 62/132 (46%)
Frame = +2
Query: 86 KMAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXX 265
K A+++ G +A I +L +T+L+ + G P LA++ VG S Y
Sbjct: 4 KTAKLLDGKAIAAKIQQELSVAITQLQPE-IGRPPGLAVLMVGDNPASAAYVRNKEKACA 62
Query: 266 XXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPD 445
P + T EL I +LN+ V GI+VQ+PL DH +DA + + PD
Sbjct: 63 KVGIASFGKHFPAETTFRELEKVIAALNDDERVDGILVQLPL-PDH-LDAVALLHQIDPD 120
Query: 446 KXVDXLNTINEG 481
K D L+ +N G
Sbjct: 121 KDADGLHPVNLG 132
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 60.5 bits (140), Expect = 6e-08
Identities = 42/135 (31%), Positives = 57/135 (42%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
+II G VA + +D+ V L + G P LA V + S Y
Sbjct: 13 RIIDGEAVAADVRDDVAAHVETLEEE--GVTPGLATVLMSDDPASETYVSMKQRDCEEVG 70
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
H+ + D EL I LNE VHGI+VQ+P+ DH +D RV ++P K V
Sbjct: 71 IESVHVEIDADAPAEELYETIDDLNEREDVHGILVQLPV-PDH-VDKRRVLRQIAPVKDV 128
Query: 455 DXLNTINEGXXAVXD 499
D + N G D
Sbjct: 129 DGFHPENVGRLVAGD 143
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 60.1 bits (139), Expect = 7e-08
Identities = 38/116 (32%), Positives = 52/116 (44%)
Frame = +2
Query: 170 KWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLN 349
K SG P L ++ VG + Y R DI E +L+ KI +
Sbjct: 111 KNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVGFKFTLDRFSSDIKEDQLIKKIKYHS 170
Query: 350 ESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAVXDLSXFIP 517
E PSVHGIIVQ+PL + DA + ++ P K VD L + N G + +IP
Sbjct: 171 EDPSVHGIIVQLPLPDNLNKDA--IIQSIDPKKDVDGLTSTNLGQIMISKKPLYIP 224
Score = 36.3 bits (80), Expect = 1.0
Identities = 17/43 (39%), Positives = 26/43 (60%)
Frame = +1
Query: 508 IYSLXTPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
+Y TP G +E++K + KNVVVL RS +VG ++ +L
Sbjct: 221 LYIPCTPLGILEILKAYKIKVEGKNVVVLGRSNLVGRTIATIL 263
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 59.7 bits (138), Expect = 1e-07
Identities = 36/128 (28%), Positives = 62/128 (48%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
I+ G +VA +L ++++ +K +P+L ++ VG S VY
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLR-KPKLVVIMVGNDPASEVYVSHKIKVANEVGI 61
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
+R +DI + EL KI LN ++ GI++Q+PL D + + A++P K VD
Sbjct: 62 YSELLRFDKDIKKEELYNKINELNNDQNIDGILLQLPLPIDFIEEDY--LQAITPSKDVD 119
Query: 458 XLNTINEG 481
+ IN+G
Sbjct: 120 GFHYINQG 127
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 59.3 bits (137), Expect = 1e-07
Identities = 39/134 (29%), Positives = 61/134 (45%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A II G VA + +++ +V + P+L + VG S Y
Sbjct: 28 AAIIDGNGVADQVLEEVKAEVDEMTRNGEK-RPKLIAILVGNNPASKAYVGRKVKAAKTV 86
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
+R IT+ ELL ++ LN+ P+V G++VQ+P+ +H I V AV+P K
Sbjct: 87 GIESETLRFEDSITQEELLHEVQKLNDDPTVDGLLVQLPV-PEH-ISEREVCQAVTPTKD 144
Query: 452 VDXLNTINEGXXAV 493
VD + N G A+
Sbjct: 145 VDGFHLSNIGNLAL 158
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/132 (28%), Positives = 64/132 (48%)
Frame = +2
Query: 86 KMAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXX 265
+ A +ISG E+A I ++++ V L ++ P L +V VG S Y
Sbjct: 5 RAAVVISGTELARQIQREIQRDVEELVAQ-GNMRPHLGVVLVGEDPASRTYVKNKTRAAS 63
Query: 266 XXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPD 445
+ P +++ ELL I +N V G++VQ+PL +H I+ V +A++P+
Sbjct: 64 ILGISSDTVVRPSSVSQEELLELIDKMNRDWRVSGLLVQLPL-PEH-INERAVCNAIAPE 121
Query: 446 KXVDXLNTINEG 481
K VD + +N G
Sbjct: 122 KDVDGFHIVNIG 133
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 58.4 bits (135), Expect = 2e-07
Identities = 50/157 (31%), Positives = 72/157 (45%), Gaps = 3/157 (1%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKW--SGFE-PRLAIVQVGGREDSNVYXXXXXXXX 262
A +ISG ++A I + R V KW +G P L++V VG S+ Y
Sbjct: 30 AVVISGRKLARQIREEARADV----EKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAA 85
Query: 263 XXXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSP 442
I DI+E ELL I LN V G++VQ+PL +H ID + +AV+P
Sbjct: 86 ADIGISSETILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPL-PEH-IDERTICNAVAP 143
Query: 443 DKXVDXLNTINEGXXAVXDLSXFIPLXLQPGAWNSLR 553
K VD + +N G + D S +P G W ++
Sbjct: 144 TKDVDGFHVVNVGRMCL-DQSSMLP-ATPWGVWEIIK 178
Score = 33.9 bits (74), Expect = 5.6
Identities = 19/38 (50%), Positives = 22/38 (57%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP G E+IK T KNVVV RS VG P++ LL
Sbjct: 169 TPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLL 206
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 58.4 bits (135), Expect = 2e-07
Identities = 42/130 (32%), Positives = 61/130 (46%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
AQ++SG E A ++ ++R RLRS F P L ++++G S Y
Sbjct: 3 AQVLSGHEAAEAVYEEIR---ARLRSL--SFTPSLRVIRLGEDPASVAYVRLKDKRARAL 57
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
P D+ E LL +I +LN V GI+VQ+PL I RV +A+ P K
Sbjct: 58 GYRSQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPH--IRTQRVLEAIHPLKD 115
Query: 452 VDXLNTINEG 481
VD + +N G
Sbjct: 116 VDGFHPLNVG 125
Score = 34.3 bits (75), Expect = 4.2
Identities = 18/38 (47%), Positives = 23/38 (60%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP G V L+K + K VVV+ RS IVG P++ LL
Sbjct: 138 TPLGVVRLLKHYGVDLRGKEVVVVGRSNIVGKPLAGLL 175
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 58.4 bits (135), Expect = 2e-07
Identities = 40/130 (30%), Positives = 60/130 (46%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A II+G +A I L + L+ ++S P L +V VG S++Y
Sbjct: 3 ANIINGKAIAEDITGTLATCINDLKLQYS-LVPCLIVVLVGDDPASHLYVRNKQRKAEML 61
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
I LP +E L+ KI LN +VHGI+VQ+P+ ID + + + + P K
Sbjct: 62 GLRSETILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPKH--IDKNLIINTIDPRKD 119
Query: 452 VDXLNTINEG 481
VD + N G
Sbjct: 120 VDGFHNDNVG 129
Score = 35.1 bits (77), Expect = 2.4
Identities = 17/38 (44%), Positives = 23/38 (60%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP GC+ LIK + + VV+ RS IVG P++ LL
Sbjct: 144 TPRGCLYLIKTVTHNLSGSDAVVIGRSNIVGKPMACLL 181
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 58.4 bits (135), Expect = 2e-07
Identities = 38/129 (29%), Positives = 60/129 (46%), Gaps = 1/129 (0%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFE-PRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
++ G + A S+ ++ ++V SG P + I+ VG S Y
Sbjct: 3 LLDGKKCAESLVAEIARKVAGYTE--SGLRTPHMTIILVGEHAPSESYVKSKIATSGLAG 60
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
+R P I E ELL KI +NE P+ G+IVQ+PL I+ V +A++P+K +
Sbjct: 61 FESTLLRFPETIRESELLAKIKEVNEDPTTDGLIVQLPLPKH--INQQHVINAIAPEKDI 118
Query: 455 DXLNTINEG 481
D + N G
Sbjct: 119 DGFHPANFG 127
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 58.0 bits (134), Expect = 3e-07
Identities = 36/130 (27%), Positives = 57/130 (43%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
AQ++ G VA ++ D+ ++V L+ K G P L + VG S Y
Sbjct: 3 AQLLEGKVVAAAVLEDVARRVAVLKDK--GISPGLGTILVGDDGPSVSYVNKKRETCKQV 60
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
H +P T+ +LL + N+SP V I+Q PL D + + + P+K
Sbjct: 61 GIASFHNEIPASATQSDLLAAVRDFNDSPDVDAYIIQYPLPK--GFDFNEALNLMLPEKD 118
Query: 452 VDXLNTINEG 481
D L+ +N G
Sbjct: 119 ADGLHPVNLG 128
Score = 34.3 bits (75), Expect = 4.2
Identities = 17/47 (36%), Positives = 25/47 (53%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXHXYCHS 663
TPAG +++ I K VVV+ R P +G P+S LL Y ++
Sbjct: 141 TPAGIRAMLQHYDIAIEGKEVVVIGRGPTLGRPLSLLLTLKQPYANA 187
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 57.6 bits (133), Expect = 4e-07
Identities = 42/131 (32%), Positives = 56/131 (42%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
M +II G VA + DL V L + +G PRLA V + ++ S Y
Sbjct: 1 MTEIIDGDAVAAQLRADLTGAVETLET--AGVTPRLATVLMNDKQASETYVSMKQQDCEE 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
+R+ + + L + LN VHGI+VQ P DH D RV AV P K
Sbjct: 59 VGIAAEDVRIDPEASADTLFDTVAELNAREDVHGILVQDP-TPDHVPD-ERVLSAVDPAK 116
Query: 449 XVDXLNTINEG 481
VD + N G
Sbjct: 117 DVDGFHPENVG 127
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/126 (30%), Positives = 61/126 (48%), Gaps = 1/126 (0%)
Frame = +2
Query: 143 RQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIE 322
++ +T L+ + P LAI+Q G ED + I L ++ +EIE
Sbjct: 8 KEMITVLQRRNPAIRPSLAIIQAG--EDDGLLEINKKMARRIGLNVT-QICLAKECSEIE 64
Query: 323 LLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAVXDL 502
++ ++ L+E P VHG+ + +P A RV A+ P+K VD L+ +N G DL
Sbjct: 65 IVTEVLKLSEDPGVHGLYLHLP----QASLTSRVLTALKPEKDVDGLSDLNTGCLIRGDL 120
Query: 503 S-XFIP 517
S F+P
Sbjct: 121 SAGFVP 126
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 56.0 bits (129), Expect = 1e-06
Identities = 40/131 (30%), Positives = 59/131 (45%)
Frame = +2
Query: 101 ISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXX 280
I G ++ S+ + +++ V L+++ G P LA V VG S Y
Sbjct: 6 IDGKVISQSVKDRVKKAVEELKNQ--GINPCLATVLVGDNPASATYVRNKHRACEEVGIT 63
Query: 281 XXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDX 460
+L T+ +L I +LN SVHGI+VQ+PL +D T +SP K VD
Sbjct: 64 TKDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQ--LDEFTTTSRISPLKDVDG 121
Query: 461 LNTINEGXXAV 493
L N G A+
Sbjct: 122 LTPHNAGLLAM 132
Score = 33.1 bits (72), Expect = 9.8
Identities = 14/38 (36%), Positives = 23/38 (60%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP+G +E+ + KN+V++ RS +VG P+ LL
Sbjct: 141 TPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLL 178
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/133 (28%), Positives = 62/133 (46%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
AQ I G ++ ++ +++ +V + R + P LA+V VG S VY
Sbjct: 3 AQNIDGTLISQTVRSEVAARV-KARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEV 61
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
LP +E LL + LN P + GI+VQ+PL + +D +V +++ P+K
Sbjct: 62 GFVSKSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPA--GMDTTKVLESIHPEKD 119
Query: 452 VDXLNTINEGXXA 490
VD + N G A
Sbjct: 120 VDGFHPYNVGRLA 132
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/134 (28%), Positives = 59/134 (44%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A I+ G +A I L +V +++K +G P LA + VG S Y
Sbjct: 14 ATILDGKALAKQIEQQLSTRVDAIKAK-TGRTPSLATILVGDDPASATYVRMKGNACQRV 72
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
+ +P T EL+ KI LN +P VHGI++Q P+ + ID + + K
Sbjct: 73 GMDSIRVEMPSATTTAELMAKIDELNNNPDVHGILLQHPVPAH--IDERACFEQIDLAKD 130
Query: 452 VDXLNTINEGXXAV 493
VD + + G A+
Sbjct: 131 VDGVTCLGFGRMAM 144
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 55.6 bits (128), Expect = 2e-06
Identities = 52/197 (26%), Positives = 80/197 (40%), Gaps = 1/197 (0%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
II G E++ I ++++++ G++PRLAI+ G E S VY
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF-----GYKPRLAILMAGDDESSKVYANSKVKACESVGI 59
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
+ + E + + LNE HGI+++MPL D +V D ++P K VD
Sbjct: 60 EAK-VYYFSEKEEDKFFDTLEKLNEDKDTHGIMIEMPLPK--GFDVDKVYDTINPYKDVD 116
Query: 458 XLNTINEGXXAVXDLSXFIPLXLQPGAWNSLRXPXSLYL-XKMW*CSGGVPLWVXRCQSC 634
++ N G F+P P A + + L K G +
Sbjct: 117 CISNYNMGRLFAGK-PLFVP--CTPKAIIHILENTGVDLEGKHAVVIGRSNILGKPVAKL 173
Query: 635 XNXNTPTVTVCHSKTKN 685
TVTVCHSKTK+
Sbjct: 174 LLDKNCTVTVCHSKTKD 190
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 55.2 bits (127), Expect = 2e-06
Identities = 43/147 (29%), Positives = 61/147 (41%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
M + + G E+A SI ND L G P+LA+VQ E + Y
Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALNDL--GTRPKLAVVQATDDESTAWYVRSIASAAKR 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
+ L + ++ + L P VHGII+Q PL +DA R +A++P K
Sbjct: 59 TGILCDIVDLGAAASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALR--EAINPAK 116
Query: 449 XVDXLNTINEGXXAVXDLSXFIPLXLQ 529
VD N ++ G V L F P Q
Sbjct: 117 DVDGANPVSLG-RLVARLPAFAPATAQ 142
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 54.8 bits (126), Expect = 3e-06
Identities = 55/197 (27%), Positives = 81/197 (41%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
M I+ G ++A + + + L+ K+ +L I+ VG + S +Y
Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQ-ITVKLVIILVGNNDASLIYVNNKVAKAKA 59
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
IRL I E +L I LN +VHGIIVQ+PL IDA ++ + K
Sbjct: 60 IGMDSEIIRLFEFIEEKKLFSVIDDLNCDSTVHGIIVQLPLPPH--IDALKLFARIDSRK 117
Query: 449 XVDXLNTINEGXXAVXDLSXFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQ 628
VD LN IN G + IP G + L+ + K G +
Sbjct: 118 DVDGLNPINIGYLNIGANQGLIPCTAL-GCIDLLQYYVTGLKGKHVVVIGKSNIVGKPLS 176
Query: 629 SCXNXNTPTVTVCHSKT 679
+ N+ TVT+CHS T
Sbjct: 177 ALLLRNSCTVTICHSAT 193
Score = 35.1 bits (77), Expect = 2.4
Identities = 16/38 (42%), Positives = 25/38 (65%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
T GC++L++ + K+VVV+ +S IVG P+S LL
Sbjct: 142 TALGCIDLLQYYVTGLKGKHVVVIGKSNIVGKPLSALL 179
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 54.0 bits (124), Expect = 5e-06
Identities = 37/140 (26%), Positives = 65/140 (46%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
++ G +A +I DL+ ++ + ++ + P+LA++ VG S Y
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQ-THKRPKLAVILVGKDPASITYVNMKIKACERVGM 66
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
L +ITE +LL I N ++ G++VQ+PL ID + +A+ P+K VD
Sbjct: 67 DFDLKTLQENITEAKLLSLIKDYNTDQNISGVLVQLPL--PRHIDTKMILEAIDPNKDVD 124
Query: 458 XLNTINEGXXAVXDLSXFIP 517
+ +N G S F+P
Sbjct: 125 GFHPLNIGKLCTQKES-FLP 143
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 53.2 bits (122), Expect = 9e-06
Identities = 38/131 (29%), Positives = 60/131 (45%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MA + G +A ++ + L+ Q+ + +G P LA+++VG S VY
Sbjct: 1 MALRLDGKALAKAVESRLQAQIESNLPQ-AGRPPGLAVLRVGDDPASAVYVANKEKACAR 59
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
LP E+L I LN P V GI++Q+PL +D + A+ P+K
Sbjct: 60 IGVASYGAHLPSSTPFAEVLSTIQQLNADPRVDGILLQLPL--PEGLDEGPLLMAIDPEK 117
Query: 449 XVDXLNTINEG 481
D L+T+N G
Sbjct: 118 DADGLHTLNLG 128
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 53.2 bits (122), Expect = 9e-06
Identities = 31/129 (24%), Positives = 62/129 (48%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
+I+ G++++ I +++++ + + K P LA++ +G S +Y
Sbjct: 4 KILDGLKISKKIIKKIKKKIEKRKKKRKKI-PGLAMIVIGNNPASLIYVNKKREACNQAG 62
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
+ L I EIEL+ I LN++ + GI++Q+PL I+ ++ ++ P K V
Sbjct: 63 FFSIYWHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPI--KINYLKIITSIDPKKDV 120
Query: 455 DXLNTINEG 481
D + N G
Sbjct: 121 DGFHPYNLG 129
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 53.2 bits (122), Expect = 9e-06
Identities = 38/134 (28%), Positives = 59/134 (44%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A++I G +AG + + +V L ++ G P LA V VG + Y
Sbjct: 3 ARVIDGRPIAGELKKRVASEVEGLAAR--GVRPGLATVLVGEDYAARAYERRVGGLAAEL 60
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
RLPR+ E ++L + LN P V GI+V PL I V A+ P K
Sbjct: 61 GCRYVCERLPREAEEADVLAVVGKLNADPRVSGILVLRPLPGH--ISEPAVFSALDPLKD 118
Query: 452 VDXLNTINEGXXAV 493
++ ++ +N G A+
Sbjct: 119 IEAVHPVNAGLLAL 132
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/168 (30%), Positives = 72/168 (42%), Gaps = 2/168 (1%)
Frame = +2
Query: 188 PRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSVH 367
P +A + VG S Y I L I E EL+ I LN +H
Sbjct: 33 PCIASITVGDDGGSLYYVNNQKKVSESLGIEFKSIFLDESIREEELIKLIEGLNVDNKIH 92
Query: 368 GIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAVXDLSXFIPLXLQPGAWNS 547
GI++Q+PL + IDA VT + +K +D L IN G + S FIP P + +
Sbjct: 93 GIMLQLPLPNH--IDAKLVTSKIDANKDIDSLTDINTGKFYKGEKS-FIP--CTPRSIIN 147
Query: 548 LRXPXSLYLXKMW*CSGGVPLWVXR--CQSCXNXNTPTVTVCHSKTKN 685
L ++ + G V + Q N N TVT+CHS+T+N
Sbjct: 148 LIKSLNVDICGKNAVVIGRSNIVGKPTAQLLLNENA-TVTICHSRTQN 194
Score = 35.9 bits (79), Expect = 1.4
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
TP + LIK I KN VV+ RS IVG P ++LL + CHS
Sbjct: 141 TPRSIINLIKSLNVDICGKNAVVIGRSNIVGKPTAQLLLNENATVTICHS 190
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 51.6 bits (118), Expect = 3e-05
Identities = 36/134 (26%), Positives = 62/134 (46%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A II G ++A I N+L+ V + + P+L ++VG S +Y
Sbjct: 110 AIIIDGKKIANKIQNELKITVDNWIND-NKKRPKLVAIKVGNNPASKIYVEKKIKAANFI 168
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
I L ++ +++ +I +LN+ +V GI+VQ+PL ++ V A+ P K
Sbjct: 169 GIENYTIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKH--MNEQEVCQAIIPSKD 226
Query: 452 VDXLNTINEGXXAV 493
VD + N G A+
Sbjct: 227 VDGFHLENLGNLAL 240
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 51.6 bits (118), Expect = 3e-05
Identities = 25/63 (39%), Positives = 40/63 (63%)
Frame = +2
Query: 305 DITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGX 484
D +E E+L ++ N+ PSVHG++VQ+PL S +D + +AVS +K VD + +N G
Sbjct: 89 DSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLNIGR 146
Query: 485 XAV 493
A+
Sbjct: 147 LAM 149
Score = 35.5 bits (78), Expect = 1.8
Identities = 17/39 (43%), Positives = 22/39 (56%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLK 639
TP GC+EL+ K VV+ RS IVG P + LL+
Sbjct: 160 TPKGCIELLHRYNIEFKGKRAVVIGRSNIVGMPAALLLQ 198
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 50.8 bits (116), Expect = 5e-05
Identities = 52/198 (26%), Positives = 82/198 (41%), Gaps = 1/198 (0%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
+II G V+ I + +Q+ ++++K P L I+Q+G + S Y
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRV-PALTIIQIGNNKASTTYIKNKKIACEKVG 63
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
+ P ITE L+ I LN + + I+VQ+PL S I++ +V + + K V
Sbjct: 64 VTCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSH--INSEKVINTIITKKDV 121
Query: 455 DXLNTINEGXXAVXDLSXFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQSC 634
D G L + L P +L + L G V + +
Sbjct: 122 DGFTPKILGNLM---LGHYNLLPSTPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLAN 178
Query: 635 XNXN-TPTVTVCHSKTKN 685
N + TVTVCHS+TKN
Sbjct: 179 LLINASATVTVCHSQTKN 196
Score = 33.5 bits (73), Expect = 7.4
Identities = 15/38 (39%), Positives = 24/38 (63%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP G + L+K + ++VV++ RS IVG P++ LL
Sbjct: 143 TPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLANLL 180
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 50.4 bits (115), Expect = 6e-05
Identities = 35/134 (26%), Positives = 63/134 (47%)
Frame = +2
Query: 92 AQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXX 271
A I+ G +A ++ +LR T+ + +G P LA+V++ G S+ Y
Sbjct: 3 AIILDGRALAKTLREELRAD-TQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEEI 61
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
LP + T+ L I++L+ ++HGI++ +PL +D+ R + P K
Sbjct: 62 GITFTDHTLPPETTQAMLEETISALSFDRTIHGILLHLPLPP--GLDSARAIAQIDPAKD 119
Query: 452 VDXLNTINEGXXAV 493
VD ++ N G A+
Sbjct: 120 VDGVHPYNAGLLAM 133
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 50.4 bits (115), Expect = 6e-05
Identities = 33/133 (24%), Positives = 64/133 (48%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXX 274
+++ G E+A +L++++ ++ G PRL ++QVG + +Y
Sbjct: 4 KLLKGEEIAEKKAEELKERIEKM-----GVSPRLVLLQVGNYSAATIYARAKIKRGKKIG 58
Query: 275 XXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXV 454
+ D+T+ EL+ +I L+ V+GI+V+ PL ID + + ++ K V
Sbjct: 59 ADVV-LEKYEDLTKQELVRRIEELSADKDVNGIMVENPLPK--TIDYYDIVKSIPYYKDV 115
Query: 455 DXLNTINEGXXAV 493
D L+ N+G A+
Sbjct: 116 DALSPYNQGSIAI 128
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 50.0 bits (114), Expect = 8e-05
Identities = 37/125 (29%), Positives = 56/125 (44%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
M I+ G EVA + L +V + + + G P+L++V VG + S+VY
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETY-GRAPQLSVVIVGDDKASHVYVKNKKIACEK 59
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDK 448
LP + T+ EL ++ LN V GI+VQ PL + + V VS +K
Sbjct: 60 IGMTSTIHTLPAETTQSELNQILSKLNNDNGVDGILVQFPLPKH--LSSDEVLKLVSAEK 117
Query: 449 XVDXL 463
D L
Sbjct: 118 DADGL 122
Score = 36.3 bits (80), Expect = 1.0
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 3/55 (5%)
Frame = +1
Query: 508 IYSLXTPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLKXXH---XYCHS 663
+ S TPAG +E++K + K VV+ RS IVG P++ LL + CHS
Sbjct: 136 LVSPCTPAGVMEILKHYRIPVEGKKAVVVGRSNIVGKPMALLLTEANATVTLCHS 190
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 49.6 bits (113), Expect = 1e-04
Identities = 37/127 (29%), Positives = 51/127 (40%)
Frame = +2
Query: 101 ISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXX 280
+ G I DL+++V L + G P L V VG S Y
Sbjct: 9 LDGKATRDEIFVDLKERVAALTEQ--GRTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGIN 66
Query: 281 XXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDX 460
LP DI++ EL I LN +P G IVQ+PL +D + + + P K D
Sbjct: 67 SIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKH--LDENAALERIDPGKDADG 124
Query: 461 LNTINEG 481
L+ N G
Sbjct: 125 LHPTNLG 131
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/93 (32%), Positives = 48/93 (51%)
Frame = +2
Query: 191 RLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSVHG 370
+L I+Q + S+ + I+L IT+ EL+ KI SLN +V G
Sbjct: 25 KLVIIQANDDDSSDSFIKQKLIACNTVGAKSELIKLSNQITQAELIEKIISLNHDVNVTG 84
Query: 371 IIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNT 469
II+Q+P+ H +D + + +A++P K VD L T
Sbjct: 85 IILQLPV-YPH-LDKNSLLEAINPLKDVDGLTT 115
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 48.0 bits (109), Expect = 3e-04
Identities = 31/127 (24%), Positives = 58/127 (45%)
Frame = +2
Query: 83 AKMAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXX 262
A+ +++G +++ + +++++ R+ + EP+LAI+ VG DS Y
Sbjct: 25 AEQPILVNGNKISKDVLQKVKERILRVNIR----EPKLAIILVGNAADSISYVSVKQRAC 80
Query: 263 XXXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSP 442
I LP T+ E++ + LN+ V I+ Q+P + I V + + P
Sbjct: 81 KRVGVQSELIHLPETTTQKEVIQIVEDLNKREDVDSILTQLPFPAQ--ISKTIVINQIEP 138
Query: 443 DKXVDXL 463
K VD L
Sbjct: 139 SKDVDGL 145
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 46.8 bits (106), Expect = 7e-04
Identities = 27/96 (28%), Positives = 45/96 (46%)
Frame = +2
Query: 188 PRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSVH 367
P LAI+QVG S Y P I++ E++ +I SLN+ S+
Sbjct: 37 PGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHRIKSLNQKGSID 96
Query: 368 GIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTIN 475
GI+VQ+PL + +++ + +K +D L+ N
Sbjct: 97 GILVQLPLPPH--LSRLEISNEIKLNKDIDCLHMAN 130
>UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1;
Treponema primitia|Rep: Methylene-THF dehydrogenase -
Treponema primitia
Length = 97
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/98 (28%), Positives = 44/98 (44%)
Frame = +2
Query: 89 MAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXX 268
MAQ++ G VA ++ L++ V L++K G P L I+++G + Y
Sbjct: 1 MAQLLDGKVVAAALAESLKKDVEALKAK--GVTPTLGIIRLGEKGPDISYEKGATKRAEE 58
Query: 269 XXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQ 382
+ LP D T+ LL I N+ VHG + Q
Sbjct: 59 VGAAVKNYILPEDTTQEALLKVIKEANDDKGVHGCLAQ 96
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 45.2 bits (102), Expect = 0.002
Identities = 32/105 (30%), Positives = 45/105 (42%)
Frame = +2
Query: 167 SKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSL 346
+K GF P+L + VG + +VY R P IT EL I L
Sbjct: 30 AKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATITSGELEAAIHGL 89
Query: 347 NESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEG 481
N P V GII+Q P+ + I + AV P K V+ ++ + G
Sbjct: 90 NADPRVTGIIIQRPVPAH--ISVKTLQAAVHPLKDVEGMHPASIG 132
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 44.4 bits (100), Expect = 0.004
Identities = 46/165 (27%), Positives = 67/165 (40%), Gaps = 3/165 (1%)
Frame = +2
Query: 194 LAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGI 373
L +V SN+Y I+ + + ++L I N++ S GI
Sbjct: 40 LKVVLANDEPASNLYVSIKSRVAKEIGLNVEVIKFSANSVQSDILEVIDRENKNLSTDGI 99
Query: 374 IVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAVXDLSXFIPLXLQPGAWNSLR 553
IVQ+PL +D + + +++ K VD L+ +N G + D FIP LR
Sbjct: 100 IVQLPLLK--GMDLNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTAL-AVLKILR 156
Query: 554 XPXSLYLXKMW*CSGGVPLWVXRCQSCXNXNTP---TVTVCHSKT 679
L K G PL V R S + P TV VCHSK+
Sbjct: 157 DEGIKTLGKTVVVVGRSPL-VGRPISILLSSKPYDATVIVCHSKS 200
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 43.6 bits (98), Expect = 0.007
Identities = 21/38 (55%), Positives = 26/38 (68%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TP GC+EL+ + +I KN VV+ RS IVG PVS LL
Sbjct: 28 TPKGCIELLHRSGISIKGKNAVVVGRSNIVGLPVSLLL 65
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 43.6 bits (98), Expect = 0.007
Identities = 32/137 (23%), Positives = 59/137 (43%)
Frame = +2
Query: 71 TVLWAKMAQIISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXX 250
T+ + A+++SG+ ++ + +R + LR P L +V VG DS Y
Sbjct: 25 TLRGLRSAELLSGVPISKQLRQRIRASTSVLRRP-----PCLVVVLVGDGADSIHYVNHK 79
Query: 251 XXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTD 430
+ L + +IEL + ++N+ V +++Q+PL + V
Sbjct: 80 MRAAADCGIEVRLVHLSATVQQIELHRTLAAVNDDVEVDAVLLQLPLPPHQRTRSALV-- 137
Query: 431 AVSPDKXVDXLNTINEG 481
+ P K VD L+ +N G
Sbjct: 138 HIHPGKDVDGLHPLNAG 154
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 43.6 bits (98), Expect = 0.007
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 1/129 (0%)
Frame = +2
Query: 95 QIISGIEVAGSIXNDLRQQVTRLRSKWSGFEP-RLAIVQVGGREDSNVYXXXXXXXXXXX 271
+I+SG E A L++++ L P +LAI+QVG + +SN Y
Sbjct: 2 KILSGREKAEQDLKQLKKELDELNLN----RPIKLAIIQVGDKMESNRYVEQKLKKAKEI 57
Query: 272 XXXXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKX 451
+ +IT+ LL + +NE + GI++Q+PL + + DAV +K
Sbjct: 58 GIEAKCFKFDENITQKRLLLAMDEINE--NWDGILIQLPLPKH--LPKEVILDAVPYEKD 113
Query: 452 VDXLNTINE 478
+D L+ NE
Sbjct: 114 IDGLSHRNE 122
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 41.5 bits (93), Expect = 0.028
Identities = 30/97 (30%), Positives = 44/97 (45%)
Frame = +2
Query: 185 EPRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPSV 364
+P IVQVG SN Y I++P I+E +L+ I ES
Sbjct: 27 KPVFTIVQVGNLFSSNKYIKTKMDKALEIGVVSRLIKIPESISEKDLISIIEE--ESKIS 84
Query: 365 HGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTIN 475
HG+IVQ+PL D ++ ++V K +D L+ N
Sbjct: 85 HGLIVQLPLPLQ--FDQSKILNSVPITKDIDGLSEKN 119
Score = 35.1 bits (77), Expect = 2.4
Identities = 17/39 (43%), Positives = 22/39 (56%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELLK 639
T G ++LIK TI K V V+ S +VG P+ EL K
Sbjct: 134 TARGIIDLIKEYNFTIKDKKVYVIGESNLVGKPIKELFK 172
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 37.1 bits (82), Expect = 0.60
Identities = 28/124 (22%), Positives = 58/124 (46%)
Frame = +2
Query: 98 IISGIEVAGSIXNDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYXXXXXXXXXXXXX 277
I++ I++A +I + + + +L+ K P +AIV++ S+ Y
Sbjct: 2 IVNCIDIANNILDKFKSDLEKLKKK--KIIPHMAIVKINDDAASDKYVSIKLKKAAELGV 59
Query: 278 XXXHIRLPRDITEIELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVD 457
I T+ +L+ +I LN S+ G I+Q+PL D++ + + + +K +D
Sbjct: 60 KTTLISEGIK-TQDDLIKQIHILNNDDSIDGYIIQLPLPK--GFDSNVICEHIDVNKDID 116
Query: 458 XLNT 469
L++
Sbjct: 117 GLSS 120
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 36.7 bits (81), Expect = 0.79
Identities = 25/98 (25%), Positives = 42/98 (42%)
Frame = +2
Query: 182 FEPRLAIVQVGGREDSNVYXXXXXXXXXXXXXXXXHIRLPRDITEIELLXKITSLNESPS 361
FEP+L V E S VY + L T+ L + L+ P+
Sbjct: 42 FEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVDLGAAATQEALEQTLRELSADPA 101
Query: 362 VHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTIN 475
VHGI++++PL + +DA ++ K ++ L+ N
Sbjct: 102 VHGIVLELPLAA--GLDADAALLHIAARKDIEGLSPAN 137
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 36.3 bits (80), Expect = 1.0
Identities = 33/120 (27%), Positives = 50/120 (41%)
Frame = +2
Query: 323 LLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINEGXXAVXDL 502
+L I ++ P+VHGIIVQ PL + + V + + K VD +N + G A+ L
Sbjct: 74 ILDTIDTVAADPTVHGIIVQTPLPG--GLTSREVGEHIPTAKDVDGMNPSSLGRLAL-GL 130
Query: 503 SXFIPLXLQPGAWNSLRXPXSLYLXKMW*CSGGVPLWVXRCQSCXNXNTPTVTVCHSKTK 682
F P R + ++ G P+ TVT+CHS+TK
Sbjct: 131 PSFAPATAAAVVEILTRARIPMSGARVCVIGRG-PVVGKPVSLLLLAEDATVTICHSRTK 189
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 35.9 bits (79), Expect = 1.4
Identities = 21/53 (39%), Positives = 28/53 (52%)
Frame = +2
Query: 320 ELLXKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLNTINE 478
E L I SLN V G+I+Q PL +D + A+SP+K VD L N+
Sbjct: 83 EALRLIESLNRRDDVTGVIIQKPLPP--FVDEKALFSALSPEKDVDALTPENK 133
Score = 33.1 bits (72), Expect = 9.8
Identities = 15/38 (39%), Positives = 24/38 (63%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TPAG +EL K + K+VVV+ + +VG P++ +L
Sbjct: 150 TPAGILELFKLYGIDVRGKDVVVVGKGELVGKPLAVML 187
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 35.9 bits (79), Expect = 1.4
Identities = 17/38 (44%), Positives = 24/38 (63%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TPAG V L+K I K +VV+ RS +VG P+S ++
Sbjct: 141 TPAGIVNLLKSQNIKIEGKKIVVIGRSLLVGKPLSLMM 178
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 34.3 bits (75), Expect = 4.2
Identities = 18/44 (40%), Positives = 25/44 (56%)
Frame = +2
Query: 335 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKXVDXLN 466
I ++N + SVHGIIV P+ D D + V+P K V+ LN
Sbjct: 78 IRAINANNSVHGIIVYYPIFGDRRDD--EIRQLVAPSKDVEGLN 119
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 33.5 bits (73), Expect = 7.4
Identities = 13/38 (34%), Positives = 25/38 (65%)
Frame = +1
Query: 523 TPAGCVELIKXTXXTIPXKNVVVLRRSPIVGTPVSELL 636
TPA C+++++ + K+VV++ R +VG P+ +LL
Sbjct: 155 TPAACLKILEEHQICLKDKHVVLIGRGRLVGQPLEQLL 192
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 640,588,637
Number of Sequences: 1657284
Number of extensions: 9861654
Number of successful extensions: 17736
Number of sequences better than 10.0: 87
Number of HSP's better than 10.0 without gapping: 17236
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 17702
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 80342087756
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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