Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP09_F_J15
(872 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U20938-1|AAB51366.1| 1025|Homo sapiens dihydropyrimidine dehydro... 136 1e-31
U09178-1|AAA57474.1| 1025|Homo sapiens dihydropyrimidine dehydro... 136 1e-31
BX908805-1|CAI15125.1| 1025|Homo sapiens dihydropyrimidine dehyd... 136 1e-31
BT006740-1|AAP35386.1| 173|Homo sapiens dihydropyrimidine dehyd... 136 1e-31
BC131778-1|AAI31779.1| 1025|Homo sapiens dihydropyrimidine dehyd... 136 1e-31
BC131777-1|AAI31778.1| 1025|Homo sapiens dihydropyrimidine dehyd... 136 1e-31
BC108742-1|AAI08743.1| 173|Homo sapiens DPYD protein protein. 136 1e-31
BC064027-1|AAH64027.1| 173|Homo sapiens DPYD protein protein. 136 1e-31
BC008379-1|AAH08379.1| 173|Homo sapiens DPYD protein protein. 136 1e-31
AL356457-3|CAH70570.1| 1025|Homo sapiens dihydropyrimidine dehyd... 136 1e-31
AB003063-1|BAA89789.1| 1025|Homo sapiens dihydropyrimidine dehyd... 136 1e-31
AB000732-1|BAA24500.1| 1324|Homo sapiens insulin receptor substr... 34 0.58
AL162497-1|CAH72369.1| 1338|Homo sapiens insulin receptor substr... 34 0.77
AF385933-1|AAK66751.1| 1338|Homo sapiens insulin receptor substr... 34 0.77
AF385932-1|AAK66750.1| 1339|Homo sapiens insulin receptor substr... 34 0.77
AF322115-1|AAG50013.1| 1338|Homo sapiens insulin receptor substr... 34 0.77
AF288517-1|AAK83053.1| 1337|Homo sapiens mutant insulin receptor... 34 0.77
AF073310-1|AAD21531.1| 1338|Homo sapiens insulin receptor substr... 34 0.77
>U20938-1|AAB51366.1| 1025|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 1025
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 108 bits (259), Expect = 3e-23
Identities = 52/85 (61%), Positives = 58/85 (68%), Gaps = 3/85 (3%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLDPNTKPLP 721
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA ++F M P +P+ P
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE 180
Query: 722 KGGD---HKIALIGGGPASIXCAXF 787
K + KIAL G GPASI CA F
Sbjct: 181 KMSEAYSAKIALFGAGPASISCASF 205
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
Score = 37.9 bits (84), Expect = 0.047
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +3
Query: 786 FLARLGYKDITVYXKDXYLGGL 851
FLARLGY DIT++ K Y+GGL
Sbjct: 205 FLARLGYSDITIFEKQEYVGGL 226
>U09178-1|AAA57474.1| 1025|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 1025
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 108 bits (259), Expect = 3e-23
Identities = 52/85 (61%), Positives = 58/85 (68%), Gaps = 3/85 (3%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLDPNTKPLP 721
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA ++F M P +P+ P
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE 180
Query: 722 KGGD---HKIALIGGGPASIXCAXF 787
K + KIAL G GPASI CA F
Sbjct: 181 KMSEAYSAKIALFGAGPASISCASF 205
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
Score = 37.9 bits (84), Expect = 0.047
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +3
Query: 786 FLARLGYKDITVYXKDXYLGGL 851
FLARLGY DIT++ K Y+GGL
Sbjct: 205 FLARLGYSDITIFEKQEYVGGL 226
>BX908805-1|CAI15125.1| 1025|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 1025
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 108 bits (259), Expect = 3e-23
Identities = 52/85 (61%), Positives = 58/85 (68%), Gaps = 3/85 (3%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLDPNTKPLP 721
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA ++F M P +P+ P
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE 180
Query: 722 KGGD---HKIALIGGGPASIXCAXF 787
K + KIAL G GPASI CA F
Sbjct: 181 KMSEAYSAKIALFGAGPASISCASF 205
Score = 55.6 bits (128), Expect = 2e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLRSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
Score = 37.9 bits (84), Expect = 0.047
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +3
Query: 786 FLARLGYKDITVYXKDXYLGGL 851
FLARLGY DIT++ K Y+GGL
Sbjct: 205 FLARLGYSDITIFEKQEYVGGL 226
>BT006740-1|AAP35386.1| 173|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 173
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 77.8 bits (183), Expect = 5e-14
Identities = 33/41 (80%), Positives = 35/41 (85%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVD 664
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA +
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATE 161
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
>BC131778-1|AAI31779.1| 1025|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 1025
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 108 bits (259), Expect = 3e-23
Identities = 52/85 (61%), Positives = 58/85 (68%), Gaps = 3/85 (3%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLDPNTKPLP 721
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA ++F M P +P+ P
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE 180
Query: 722 KGGD---HKIALIGGGPASIXCAXF 787
K + KIAL G GPASI CA F
Sbjct: 181 KMSEAYSAKIALFGAGPASISCASF 205
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
Score = 37.9 bits (84), Expect = 0.047
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +3
Query: 786 FLARLGYKDITVYXKDXYLGGL 851
FLARLGY DIT++ K Y+GGL
Sbjct: 205 FLARLGYSDITIFEKQEYVGGL 226
>BC131777-1|AAI31778.1| 1025|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 1025
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 108 bits (259), Expect = 3e-23
Identities = 52/85 (61%), Positives = 58/85 (68%), Gaps = 3/85 (3%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLDPNTKPLP 721
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA ++F M P +P+ P
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE 180
Query: 722 KGGD---HKIALIGGGPASIXCAXF 787
K + KIAL G GPASI CA F
Sbjct: 181 KMSEAYSAKIALFGAGPASISCASF 205
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
Score = 37.9 bits (84), Expect = 0.047
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +3
Query: 786 FLARLGYKDITVYXKDXYLGGL 851
FLARLGY DIT++ K Y+GGL
Sbjct: 205 FLARLGYSDITIFEKQEYVGGL 226
>BC108742-1|AAI08743.1| 173|Homo sapiens DPYD protein protein.
Length = 173
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 74.5 bits (175), Expect = 4e-13
Identities = 32/41 (78%), Positives = 34/41 (82%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVD 664
P GLTCGMVC TSDLCVGGCNL+ATE G I IGGLQ FA +
Sbjct: 121 PLGLTCGMVCSTSDLCVGGCNLYATEEGPINIGGLQQFATE 161
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
>BC064027-1|AAH64027.1| 173|Homo sapiens DPYD protein protein.
Length = 173
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 77.8 bits (183), Expect = 5e-14
Identities = 33/41 (80%), Positives = 35/41 (85%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVD 664
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA +
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATE 161
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
>BC008379-1|AAH08379.1| 173|Homo sapiens DPYD protein protein.
Length = 173
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 77.8 bits (183), Expect = 5e-14
Identities = 33/41 (80%), Positives = 35/41 (85%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVD 664
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA +
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATE 161
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
>AL356457-3|CAH70570.1| 1025|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 1025
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 108 bits (259), Expect = 3e-23
Identities = 52/85 (61%), Positives = 58/85 (68%), Gaps = 3/85 (3%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLDPNTKPLP 721
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA ++F M P +P+ P
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE 180
Query: 722 KGGD---HKIALIGGGPASIXCAXF 787
K + KIAL G GPASI CA F
Sbjct: 181 KMSEAYSAKIALFGAGPASISCASF 205
Score = 55.6 bits (128), Expect = 2e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLRSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
Score = 37.9 bits (84), Expect = 0.047
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +3
Query: 786 FLARLGYKDITVYXKDXYLGGL 851
FLARLGY DIT++ K Y+GGL
Sbjct: 205 FLARLGYSDITIFEKQEYVGGL 226
>AB003063-1|BAA89789.1| 1025|Homo sapiens dihydropyrimidine
dehydrogenase protein.
Length = 1025
Score = 136 bits (328), Expect = 1e-31
Identities = 60/77 (77%), Positives = 65/77 (84%)
Frame = +1
Query: 319 ENVLHVQPXNKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQIDVKSFITSIAN 498
+N + + NFDDIKHTTL ERGALREA RCLKCADAPCQKSCPT +D+KSFITSIAN
Sbjct: 47 KNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIAN 106
Query: 499 KNYYGAAKAILSDNPLG 549
KNYYGAAK I SDNPLG
Sbjct: 107 KNYYGAAKMIFSDNPLG 123
Score = 108 bits (259), Expect = 3e-23
Identities = 52/85 (61%), Positives = 58/85 (68%), Gaps = 3/85 (3%)
Frame = +2
Query: 542 PSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLDPNTKPLP 721
P GLTCGMVCPTSDLCVGGCNL+ATE G I IGGLQ FA ++F M P +P+ P
Sbjct: 121 PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE 180
Query: 722 KGGD---HKIALIGGGPASIXCAXF 787
K + KIAL G GPASI CA F
Sbjct: 181 KMSEAYSAKIALFGAGPASISCASF 205
Score = 56.4 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +3
Query: 180 MAXLLSKXLPDIEXLLKLNPTVKPYTNLVPSAQTKKXKQHWKRNADRKCTTCPTLXQEF 356
MA +LSK DIE +L LNP + + L ++ K K+HWKRN D+ C C L F
Sbjct: 1 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNF 59
Score = 37.9 bits (84), Expect = 0.047
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +3
Query: 786 FLARLGYKDITVYXKDXYLGGL 851
FLARLGY DIT++ K Y+GGL
Sbjct: 205 FLARLGYSDITIFEKQEYVGGL 226
>AB000732-1|BAA24500.1| 1324|Homo sapiens insulin receptor substrate-2
protein.
Length = 1324
Score = 34.3 bits (75), Expect = 0.58
Identities = 25/71 (35%), Positives = 34/71 (47%)
Frame = +2
Query: 521 RPFYQTIPSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLD 700
RP+ P GL + CP S GG + E A GL++ A+D+ + G PP
Sbjct: 1218 RPWTPGQPGGL---VGCPGS----GGSPMRR-ETSAGFQNGLKYIAIDVREEPGLPPQPQ 1269
Query: 701 PNTKPLPKGGD 733
P PLP+ GD
Sbjct: 1270 PPPPPLPQPGD 1280
>AL162497-1|CAH72369.1| 1338|Homo sapiens insulin receptor substrate 2
protein.
Length = 1338
Score = 33.9 bits (74), Expect = 0.77
Identities = 25/71 (35%), Positives = 33/71 (46%)
Frame = +2
Query: 521 RPFYQTIPSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLD 700
RP+ P GL + CP S GG + E A GL + A+D+ + G PP
Sbjct: 1218 RPWTPGQPGGL---VGCPGS----GGSPMRR-ETSAGFQNGLNYIAIDVREEPGLPPQPQ 1269
Query: 701 PNTKPLPKGGD 733
P PLP+ GD
Sbjct: 1270 PPPPPLPQPGD 1280
>AF385933-1|AAK66751.1| 1338|Homo sapiens insulin receptor substrate 2
insertion mutant protein.
Length = 1338
Score = 33.9 bits (74), Expect = 0.77
Identities = 25/71 (35%), Positives = 33/71 (46%)
Frame = +2
Query: 521 RPFYQTIPSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLD 700
RP+ P GL + CP S GG + E A GL + A+D+ + G PP
Sbjct: 1219 RPWTPGQPGGL---VGCPGS----GGSPMRR-ETSAGFQNGLNYIAIDVREEPGLPPQPQ 1270
Query: 701 PNTKPLPKGGD 733
P PLP+ GD
Sbjct: 1271 PPPPPLPQPGD 1281
>AF385932-1|AAK66750.1| 1339|Homo sapiens insulin receptor substrate 2
insertion mutant protein.
Length = 1339
Score = 33.9 bits (74), Expect = 0.77
Identities = 25/71 (35%), Positives = 33/71 (46%)
Frame = +2
Query: 521 RPFYQTIPSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLD 700
RP+ P GL + CP S GG + E A GL + A+D+ + G PP
Sbjct: 1220 RPWTPGQPGGL---VGCPGS----GGSPMRR-ETSAGFQNGLNYIAIDVREEPGLPPQPQ 1271
Query: 701 PNTKPLPKGGD 733
P PLP+ GD
Sbjct: 1272 PPPPPLPQPGD 1282
>AF322115-1|AAG50013.1| 1338|Homo sapiens insulin receptor substrate 2
protein.
Length = 1338
Score = 33.9 bits (74), Expect = 0.77
Identities = 25/71 (35%), Positives = 33/71 (46%)
Frame = +2
Query: 521 RPFYQTIPSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLD 700
RP+ P GL + CP S GG + E A GL + A+D+ + G PP
Sbjct: 1218 RPWTPGQPGGL---VGCPGS----GGSPMRR-ETSAGFQNGLNYIAIDVREEPGLPPQPQ 1269
Query: 701 PNTKPLPKGGD 733
P PLP+ GD
Sbjct: 1270 PPPPPLPQPGD 1280
>AF288517-1|AAK83053.1| 1337|Homo sapiens mutant insulin receptor
substrate 2 protein.
Length = 1337
Score = 33.9 bits (74), Expect = 0.77
Identities = 25/71 (35%), Positives = 33/71 (46%)
Frame = +2
Query: 521 RPFYQTIPSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLD 700
RP+ P GL + CP S GG + E A GL + A+D+ + G PP
Sbjct: 1218 RPWTPGQPGGL---VGCPGS----GGSPMRR-ETSAGFQNGLNYIAIDVREEPGLPPQPQ 1269
Query: 701 PNTKPLPKGGD 733
P PLP+ GD
Sbjct: 1270 PPPPPLPQPGD 1280
>AF073310-1|AAD21531.1| 1338|Homo sapiens insulin receptor substrate-2
protein.
Length = 1338
Score = 33.9 bits (74), Expect = 0.77
Identities = 25/71 (35%), Positives = 33/71 (46%)
Frame = +2
Query: 521 RPFYQTIPSGLTCGMVCPTSDLCVGGCNLHATEXGAIXIGGLQHFAVDIFMKMGXPPTLD 700
RP+ P GL + CP S GG + E A GL + A+D+ + G PP
Sbjct: 1218 RPWTPGQPGGL---VGCPGS----GGSPMRR-ETSAGFQNGLNYIAIDVREEPGLPPQPQ 1269
Query: 701 PNTKPLPKGGD 733
P PLP+ GD
Sbjct: 1270 PPPPPLPQPGD 1280
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 113,507,282
Number of Sequences: 237096
Number of extensions: 2279573
Number of successful extensions: 4032
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 3769
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4025
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 11104084400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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