Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP07_F_K04
(853 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 156 1e-37
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 156 1e-37
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 156 1e-37
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 156 1e-37
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 140 8e-33
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 140 8e-33
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 140 8e-33
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 139 1e-32
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 138 3e-32
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 138 3e-32
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 136 1e-31
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 136 1e-31
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 134 3e-31
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 133 9e-31
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 80 1e-14
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 80 1e-14
AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase ... 74 8e-13
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 63 1e-09
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 57 7e-08
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 55 4e-07
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 53 2e-06
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 44 0.001
S61396-1|AAD13928.1| 26|Homo sapiens PAH protein. 41 0.005
BC050663-1|AAH50663.1| 381|Homo sapiens SH3KBP1 protein protein. 34 0.57
BC015806-1|AAH15806.1| 665|Homo sapiens SH3-domain kinase bindi... 34 0.57
AY542305-1|AAT08174.1| 665|Homo sapiens GIG10 protein. 34 0.57
AY423734-1|AAS00497.1| 665|Homo sapiens migration-inducing gene... 34 0.57
AL772197-2|CAH71710.1| 665|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL772197-1|CAH71709.1| 553|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732423-6|CAI40280.1| 645|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732423-4|CAI40277.1| 628|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732423-3|CAI40276.1| 665|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732327-7|CAI40515.1| 208|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732327-6|CAI40514.1| 645|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732327-3|CAI40511.1| 628|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732327-2|CAI40510.1| 665|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732327-1|CAI40509.1| 553|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732325-3|CAI41254.1| 628|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732325-2|CAI41253.1| 665|Homo sapiens SH3-domain kinase bindi... 34 0.57
AL732325-1|CAI41252.1| 553|Homo sapiens SH3-domain kinase bindi... 34 0.57
AF542051-1|AAN77231.1| 628|Homo sapiens CD2 binding protein CD2... 34 0.57
AF230904-1|AAF37854.1| 665|Homo sapiens c-Cbl-interacting prote... 34 0.57
AL591719-1|CAH72065.1| 596|Homo sapiens fibronectin type III do... 33 1.3
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 156 bits (378), Expect = 1e-37
Identities = 87/172 (50%), Positives = 107/172 (62%), Gaps = 2/172 (1%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK IAEIAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+
Sbjct: 228 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLER 287
Query: 369 ADIFVPHRIPQLEDVSSFL--A*AHWLYPGXRLLVF*RHVTSSPRLXXRVFQSTQYVRHN 542
+ IPQLEDVS FL L P LL + S L RVFQ TQY+RH
Sbjct: 288 FSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLAS---LAFRVFQCTQYIRHA 344
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+SP H+PEPDC HELLGH+P+LAD +FA F+++ GASD EIEKLST
Sbjct: 345 SSPMHSPEPDCCHELLGHVPMLADRTFAQ-FSQDIGLASLGASDEEIEKLST 395
Score = 76.2 bits (179), Expect = 1e-13
Identities = 40/75 (53%), Positives = 49/75 (65%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQ+IGL A K L WFTVEFGLCK+ ++KAYGA LLSS GELLH L+
Sbjct: 373 QFSQDIGLASLGASDEEIEKLSTLS-WFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLS 431
Query: 808 DQPELXXFEPAXTXV 852
++PE+ F+P V
Sbjct: 432 EEPEIRAFDPEAAAV 446
Score = 72.9 bits (171), Expect = 1e-12
Identities = 52/148 (35%), Positives = 72/148 (48%), Gaps = 5/148 (3%)
Frame = +2
Query: 71 KTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQKTDCGNRFRLQIR*PDSV 250
K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR +K F Q R D +
Sbjct: 189 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAF--QYRHGDPI 246
Query: 251 YRIH*NRE----W-HLATSVQHRA*FDAQTRVQRVQGCVRETTGSRHIRTSSYSTTGRCQ 415
R+ E W + T+++ A + +G R R
Sbjct: 247 PRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSR-- 304
Query: 416 *LLGVSTLALPWRXAAGLLTARDFLASL 499
L T R AGLL+ARDFLASL
Sbjct: 305 -FLKERT-GFQLRPVAGLLSARDFLASL 330
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 156 bits (378), Expect = 1e-37
Identities = 87/172 (50%), Positives = 107/172 (62%), Gaps = 2/172 (1%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK IAEIAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+
Sbjct: 201 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLER 260
Query: 369 ADIFVPHRIPQLEDVSSFL--A*AHWLYPGXRLLVF*RHVTSSPRLXXRVFQSTQYVRHN 542
+ IPQLEDVS FL L P LL + S L RVFQ TQY+RH
Sbjct: 261 FSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLAS---LAFRVFQCTQYIRHA 317
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+SP H+PEPDC HELLGH+P+LAD +FA F+++ GASD EIEKLST
Sbjct: 318 SSPMHSPEPDCCHELLGHVPMLADRTFAQ-FSQDIGLASLGASDEEIEKLST 368
Score = 76.2 bits (179), Expect = 1e-13
Identities = 40/75 (53%), Positives = 49/75 (65%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQ+IGL A K L WFTVEFGLCK+ ++KAYGA LLSS GELLH L+
Sbjct: 346 QFSQDIGLASLGASDEEIEKLSTLS-WFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLS 404
Query: 808 DQPELXXFEPAXTXV 852
++PE+ F+P V
Sbjct: 405 EEPEIRAFDPEAAAV 419
Score = 72.9 bits (171), Expect = 1e-12
Identities = 52/148 (35%), Positives = 72/148 (48%), Gaps = 5/148 (3%)
Frame = +2
Query: 71 KTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQKTDCGNRFRLQIR*PDSV 250
K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR +K F Q R D +
Sbjct: 162 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAF--QYRHGDPI 219
Query: 251 YRIH*NRE----W-HLATSVQHRA*FDAQTRVQRVQGCVRETTGSRHIRTSSYSTTGRCQ 415
R+ E W + T+++ A + +G R R
Sbjct: 220 PRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSR-- 277
Query: 416 *LLGVSTLALPWRXAAGLLTARDFLASL 499
L T R AGLL+ARDFLASL
Sbjct: 278 -FLKERT-GFQLRPVAGLLSARDFLASL 303
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 156 bits (378), Expect = 1e-37
Identities = 87/172 (50%), Positives = 107/172 (62%), Gaps = 2/172 (1%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK IAEIAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+
Sbjct: 232 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLER 291
Query: 369 ADIFVPHRIPQLEDVSSFL--A*AHWLYPGXRLLVF*RHVTSSPRLXXRVFQSTQYVRHN 542
+ IPQLEDVS FL L P LL + S L RVFQ TQY+RH
Sbjct: 292 FSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLAS---LAFRVFQCTQYIRHA 348
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+SP H+PEPDC HELLGH+P+LAD +FA F+++ GASD EIEKLST
Sbjct: 349 SSPMHSPEPDCCHELLGHVPMLADRTFAQ-FSQDIGLASLGASDEEIEKLST 399
Score = 76.2 bits (179), Expect = 1e-13
Identities = 40/75 (53%), Positives = 49/75 (65%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQ+IGL A K L WFTVEFGLCK+ ++KAYGA LLSS GELLH L+
Sbjct: 377 QFSQDIGLASLGASDEEIEKLSTLS-WFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLS 435
Query: 808 DQPELXXFEPAXTXV 852
++PE+ F+P V
Sbjct: 436 EEPEIRAFDPEAAAV 450
Score = 72.9 bits (171), Expect = 1e-12
Identities = 52/148 (35%), Positives = 72/148 (48%), Gaps = 5/148 (3%)
Frame = +2
Query: 71 KTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQKTDCGNRFRLQIR*PDSV 250
K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR +K F Q R D +
Sbjct: 193 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAF--QYRHGDPI 250
Query: 251 YRIH*NRE----W-HLATSVQHRA*FDAQTRVQRVQGCVRETTGSRHIRTSSYSTTGRCQ 415
R+ E W + T+++ A + +G R R
Sbjct: 251 PRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSR-- 308
Query: 416 *LLGVSTLALPWRXAAGLLTARDFLASL 499
L T R AGLL+ARDFLASL
Sbjct: 309 -FLKERT-GFQLRPVAGLLSARDFLASL 334
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 156 bits (378), Expect = 1e-37
Identities = 87/172 (50%), Positives = 107/172 (62%), Gaps = 2/172 (1%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK IAEIAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+
Sbjct: 201 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLER 260
Query: 369 ADIFVPHRIPQLEDVSSFL--A*AHWLYPGXRLLVF*RHVTSSPRLXXRVFQSTQYVRHN 542
+ IPQLEDVS FL L P LL + S L RVFQ TQY+RH
Sbjct: 261 FSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLAS---LAFRVFQCTQYIRHA 317
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+SP H+PEPDC HELLGH+P+LAD +FA F+++ GASD EIEKLST
Sbjct: 318 SSPMHSPEPDCCHELLGHVPMLADRTFAQ-FSQDIGLASLGASDEEIEKLST 368
Score = 79.8 bits (188), Expect = 1e-14
Identities = 41/75 (54%), Positives = 50/75 (66%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQ+IGL A K L YWFTVEFGLCK+ ++KAYGA LLSS GELLH L+
Sbjct: 346 QFSQDIGLASLGASDEEIEKLSTL-YWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLS 404
Query: 808 DQPELXXFEPAXTXV 852
++PE+ F+P V
Sbjct: 405 EEPEIRAFDPEAAAV 419
Score = 72.9 bits (171), Expect = 1e-12
Identities = 52/148 (35%), Positives = 72/148 (48%), Gaps = 5/148 (3%)
Frame = +2
Query: 71 KTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQKTDCGNRFRLQIR*PDSV 250
K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR +K F Q R D +
Sbjct: 162 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAF--QYRHGDPI 219
Query: 251 YRIH*NRE----W-HLATSVQHRA*FDAQTRVQRVQGCVRETTGSRHIRTSSYSTTGRCQ 415
R+ E W + T+++ A + +G R R
Sbjct: 220 PRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSR-- 277
Query: 416 *LLGVSTLALPWRXAAGLLTARDFLASL 499
L T R AGLL+ARDFLASL
Sbjct: 278 -FLKERT-GFQLRPVAGLLSARDFLASL 303
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 140 bits (338), Expect = 8e-33
Identities = 75/170 (44%), Positives = 95/170 (55%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK ++A YKYG PIP + YTE E TW VF + L P HACREY F L
Sbjct: 189 QRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTK 248
Query: 369 ADIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSPRLXXRVFQSTQYVRHNNS 548
+ +PQLEDVS FL + + + L RVF TQY+RH +
Sbjct: 249 YCGYREDNVPQLEDVSMFLKERSG-FTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSD 307
Query: 549 PFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
P +TPEPD HELLGH+PLLADP FA F++ GASD +++KL+T
Sbjct: 308 PLYTPEPDTCHELLGHVPLLADPKFAQ-FSQEIGLASLGASDEDVQKLAT 356
Score = 74.1 bits (174), Expect = 6e-13
Identities = 41/77 (53%), Positives = 49/77 (63%)
Frame = +1
Query: 616 PASPQFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELL 795
P QFSQEIGL A K Y+FT+EFGLCK+ QL+AYGA LLSSIGEL
Sbjct: 330 PKFAQFSQEIGLASLGASDEDVQK-LATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELK 388
Query: 796 HALNDQPELXXFEPAXT 846
HAL+D+ + F+P T
Sbjct: 389 HALSDKACVKAFDPKTT 405
Score = 57.2 bits (132), Expect = 7e-08
Identities = 24/50 (48%), Positives = 29/50 (58%)
Frame = +2
Query: 50 TENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
TE PWFPR S+LD C+H + Y ELD +HPGF D YR +K
Sbjct: 143 TEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRK 192
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 140 bits (338), Expect = 8e-33
Identities = 75/170 (44%), Positives = 95/170 (55%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK ++A YKYG PIP + YTE E TW VF + L P HACREY F L
Sbjct: 195 QRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTK 254
Query: 369 ADIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSPRLXXRVFQSTQYVRHNNS 548
+ +PQLEDVS FL + + + L RVF TQY+RH +
Sbjct: 255 YCGYREDNVPQLEDVSMFLKERSG-FTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSD 313
Query: 549 PFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
P +TPEPD HELLGH+PLLADP FA F++ GASD +++KL+T
Sbjct: 314 PLYTPEPDTCHELLGHVPLLADPKFAQ-FSQEIGLASLGASDEDVQKLAT 362
Score = 74.1 bits (174), Expect = 6e-13
Identities = 41/77 (53%), Positives = 49/77 (63%)
Frame = +1
Query: 616 PASPQFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELL 795
P QFSQEIGL A K Y+FT+EFGLCK+ QL+AYGA LLSSIGEL
Sbjct: 336 PKFAQFSQEIGLASLGASDEDVQK-LATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELK 394
Query: 796 HALNDQPELXXFEPAXT 846
HAL+D+ + F+P T
Sbjct: 395 HALSDKACVKAFDPKTT 411
Score = 57.2 bits (132), Expect = 7e-08
Identities = 24/50 (48%), Positives = 29/50 (58%)
Frame = +2
Query: 50 TENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
TE PWFPR S+LD C+H + Y ELD +HPGF D YR +K
Sbjct: 149 TEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRK 198
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 140 bits (338), Expect = 8e-33
Identities = 75/170 (44%), Positives = 95/170 (55%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK ++A YKYG PIP + YTE E TW VF + L P HACREY F L
Sbjct: 189 QRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTK 248
Query: 369 ADIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSPRLXXRVFQSTQYVRHNNS 548
+ +PQLEDVS FL + + + L RVF TQY+RH +
Sbjct: 249 YCGYREDNVPQLEDVSMFLKERSG-FTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSD 307
Query: 549 PFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
P +TPEPD HELLGH+PLLADP FA F++ GASD +++KL+T
Sbjct: 308 PLYTPEPDTCHELLGHVPLLADPKFAQ-FSQEIGLASLGASDEDVQKLAT 356
Score = 74.1 bits (174), Expect = 6e-13
Identities = 41/77 (53%), Positives = 49/77 (63%)
Frame = +1
Query: 616 PASPQFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELL 795
P QFSQEIGL A K Y+FT+EFGLCK+ QL+AYGA LLSSIGEL
Sbjct: 330 PKFAQFSQEIGLASLGASDEDVQK-LATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELK 388
Query: 796 HALNDQPELXXFEPAXT 846
HAL+D+ + F+P T
Sbjct: 389 HALSDKACVKAFDPKTT 405
Score = 57.2 bits (132), Expect = 7e-08
Identities = 24/50 (48%), Positives = 29/50 (58%)
Frame = +2
Query: 50 TENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
TE PWFPR S+LD C+H + Y ELD +HPGF D YR +K
Sbjct: 143 TEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRK 192
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 139 bits (337), Expect = 1e-32
Identities = 80/175 (45%), Positives = 103/175 (58%), Gaps = 5/175 (2%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK A+ A +YKYGDPIP + +TE E TW VF + L P HACREY L
Sbjct: 143 KRRKYFADSAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLSK 202
Query: 369 ADIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSPR-----LXXRVFQSTQYV 533
+ IPQLED+S+FL G + ++ SPR L RVF TQYV
Sbjct: 203 YCGYQEDNIPQLEDISNFLKER----TGFSIRPVAGYL--SPRDFLSGLAFRVFHCTQYV 256
Query: 534 RHNNSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
RH++ PF+TPEPD HELLGH+PLLA+PSFA F++ GAS+ ++KL+T
Sbjct: 257 RHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQ-FSQEIGLASLGASEEAVQKLAT 310
Score = 68.9 bits (161), Expect = 2e-11
Identities = 37/77 (48%), Positives = 46/77 (59%)
Frame = +1
Query: 616 PASPQFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELL 795
P+ QFSQEIGL A K Y+FTVEFGLCK+ QL+ +GA LLSSI EL
Sbjct: 284 PSFAQFSQEIGLASLGASEEAVQK-LATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELK 342
Query: 796 HALNDQPELXXFEPAXT 846
H L+ ++ F+P T
Sbjct: 343 HVLSGHAKVKPFDPKIT 359
Score = 54.4 bits (125), Expect = 5e-07
Identities = 24/53 (45%), Positives = 32/53 (60%)
Frame = +2
Query: 41 FLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
F + E + S PWFP+ SDLD+C + + Y ELD +HPGF D YR +K
Sbjct: 95 FTMKEEGMES-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRK 146
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 138 bits (333), Expect = 3e-32
Identities = 80/175 (45%), Positives = 103/175 (58%), Gaps = 5/175 (2%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK A++A YK+GDPIP + +TE E TW VF + L P HACREY L
Sbjct: 143 KRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSK 202
Query: 369 ADIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSPR-----LXXRVFQSTQYV 533
+ IPQLEDVS+FL G + ++ SPR L RVF TQYV
Sbjct: 203 YCGYREDNIPQLEDVSNFLKER----TGFSIRPVAGYL--SPRDFLSGLAFRVFHCTQYV 256
Query: 534 RHNNSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
RH++ PF+TPEPD HELLGH+PLLA+PSFA F++ GAS+ ++KL+T
Sbjct: 257 RHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQ-FSQEIGLASLGASEEAVQKLAT 310
Score = 70.5 bits (165), Expect = 7e-12
Identities = 38/77 (49%), Positives = 47/77 (61%)
Frame = +1
Query: 616 PASPQFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELL 795
P+ QFSQEIGL A K Y+FTVEFGLCK+ QL+ +GA LLSSI EL
Sbjct: 284 PSFAQFSQEIGLASLGASEEAVQK-LATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELK 342
Query: 796 HALNDQPELXXFEPAXT 846
HAL+ ++ F+P T
Sbjct: 343 HALSGHAKVKPFDPKIT 359
Score = 54.4 bits (125), Expect = 5e-07
Identities = 24/53 (45%), Positives = 33/53 (62%)
Frame = +2
Query: 41 FLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
F L E+ + + PWFP+ SDLD+C + + Y ELD +HPGF D YR +K
Sbjct: 95 FTLKEDGMET-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRK 146
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 138 bits (333), Expect = 3e-32
Identities = 80/175 (45%), Positives = 103/175 (58%), Gaps = 5/175 (2%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 368
+RRK A++A YK+GDPIP + +TE E TW VF + L P HACREY L
Sbjct: 143 KRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSK 202
Query: 369 ADIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSPR-----LXXRVFQSTQYV 533
+ IPQLEDVS+FL G + ++ SPR L RVF TQYV
Sbjct: 203 YCGYREDNIPQLEDVSNFLKER----TGFSIRPVAGYL--SPRDFLSGLAFRVFHCTQYV 256
Query: 534 RHNNSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
RH++ PF+TPEPD HELLGH+PLLA+PSFA F++ GAS+ ++KL+T
Sbjct: 257 RHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQ-FSQEIGLASLGASEEAVQKLAT 310
Score = 70.5 bits (165), Expect = 7e-12
Identities = 38/77 (49%), Positives = 47/77 (61%)
Frame = +1
Query: 616 PASPQFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELL 795
P+ QFSQEIGL A K Y+FTVEFGLCK+ QL+ +GA LLSSI EL
Sbjct: 284 PSFAQFSQEIGLASLGASEEAVQK-LATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELK 342
Query: 796 HALNDQPELXXFEPAXT 846
HAL+ ++ F+P T
Sbjct: 343 HALSGHAKVKPFDPKIT 359
Score = 54.4 bits (125), Expect = 5e-07
Identities = 24/53 (45%), Positives = 33/53 (62%)
Frame = +2
Query: 41 FLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
F L E+ + + PWFP+ SDLD+C + + Y ELD +HPGF D YR +K
Sbjct: 95 FTLKEDGMET-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRK 146
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 136 bits (328), Expect = 1e-31
Identities = 79/172 (45%), Positives = 96/172 (55%), Gaps = 3/172 (1%)
Frame = +3
Query: 192 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 371
RRKQ A+IA+ Y++G PIP + Y E E TW VF T+ L HAC EY F L+
Sbjct: 157 RRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKY 216
Query: 372 DIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSP---RLXXRVFQSTQYVRHN 542
F IPQLEDVS FL G RL ++S L RVF TQY+RH
Sbjct: 217 CGFHEDNIPQLEDVSQFLQ----TCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHG 272
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+ P +TPEPD HELLGH+PL +D SFA F++ GA D IEKL+T
Sbjct: 273 SKPMYTPEPDICHELLGHVPLFSDRSFAQ-FSQEIGLASLGAPDEYIEKLAT 323
Score = 73.3 bits (172), Expect = 1e-12
Identities = 38/75 (50%), Positives = 47/75 (62%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQEIGL A K +YWFTVEFGLCK+ +KAYGA LLSS GEL + L+
Sbjct: 301 QFSQEIGLASLGAPDEYIEK-LATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLS 359
Query: 808 DQPELXXFEPAXTXV 852
++P+L E T +
Sbjct: 360 EKPKLLPLELEKTAI 374
Score = 46.8 bits (106), Expect = 1e-04
Identities = 20/51 (39%), Positives = 27/51 (52%)
Frame = +2
Query: 47 LTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
L+ + PWFPR +LD + + Y ELD +HPGF D YR +K
Sbjct: 109 LSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 136 bits (328), Expect = 1e-31
Identities = 79/172 (45%), Positives = 96/172 (55%), Gaps = 3/172 (1%)
Frame = +3
Query: 192 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 371
RRKQ A+IA+ Y++G PIP + Y E E TW VF T+ L HAC EY F L+
Sbjct: 157 RRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKY 216
Query: 372 DIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSP---RLXXRVFQSTQYVRHN 542
F IPQLEDVS FL G RL ++S L RVF TQY+RH
Sbjct: 217 CGFHEDNIPQLEDVSQFLQ----TCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHG 272
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+ P +TPEPD HELLGH+PL +D SFA F++ GA D IEKL+T
Sbjct: 273 SKPMYTPEPDICHELLGHVPLFSDRSFAQ-FSQEIGLASLGAPDEYIEKLAT 323
Score = 73.3 bits (172), Expect = 1e-12
Identities = 38/75 (50%), Positives = 47/75 (62%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQEIGL A K +YWFTVEFGLCK+ +KAYGA LLSS GEL + L+
Sbjct: 301 QFSQEIGLASLGAPDEYIEK-LATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLS 359
Query: 808 DQPELXXFEPAXTXV 852
++P+L E T +
Sbjct: 360 EKPKLLPLELEKTAI 374
Score = 46.8 bits (106), Expect = 1e-04
Identities = 20/51 (39%), Positives = 27/51 (52%)
Frame = +2
Query: 47 LTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
L+ + PWFPR +LD + + Y ELD +HPGF D YR +K
Sbjct: 109 LSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 134 bits (325), Expect = 3e-31
Identities = 78/172 (45%), Positives = 96/172 (55%), Gaps = 3/172 (1%)
Frame = +3
Query: 192 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 371
RRKQ A+IA+ Y++G PIP + Y E E TW VF T+ L HAC EY F L+
Sbjct: 157 RRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKY 216
Query: 372 DIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSP---RLXXRVFQSTQYVRHN 542
F IPQLEDVS FL G RL ++S L RVF TQY+RH
Sbjct: 217 CGFHEDNIPQLEDVSQFLQ----TCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHG 272
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+ P +TP+PD HELLGH+PL +D SFA F++ GA D IEKL+T
Sbjct: 273 SKPMYTPQPDICHELLGHVPLFSDRSFAQ-FSQEIGLASLGAPDEYIEKLAT 323
Score = 73.3 bits (172), Expect = 1e-12
Identities = 38/75 (50%), Positives = 47/75 (62%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQEIGL A K +YWFTVEFGLCK+ +KAYGA LLSS GEL + L+
Sbjct: 301 QFSQEIGLASLGAPDEYIEK-LATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLS 359
Query: 808 DQPELXXFEPAXTXV 852
++P+L E T +
Sbjct: 360 EKPKLLPLELEKTAI 374
Score = 46.8 bits (106), Expect = 1e-04
Identities = 20/51 (39%), Positives = 27/51 (52%)
Frame = +2
Query: 47 LTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
L+ + PWFPR +LD + + Y ELD +HPGF D YR +K
Sbjct: 109 LSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 133 bits (321), Expect = 9e-31
Identities = 78/172 (45%), Positives = 95/172 (55%), Gaps = 3/172 (1%)
Frame = +3
Query: 192 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 371
RRKQ A+IA+ Y++G PIP + Y E TW VF T+ L HAC EY F L+
Sbjct: 157 RRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKY 216
Query: 372 DIFVPHRIPQLEDVSSFLA*AHWLYPGXRLLVF*RHVTSSP---RLXXRVFQSTQYVRHN 542
F IPQLEDVS FL G RL ++S L RVF TQY+RH
Sbjct: 217 CGFHEDNIPQLEDVSQFLQ----TCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHG 272
Query: 543 NSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
+ P +TPEPD HELLGH+PL +D SFA F++ GA D IEKL+T
Sbjct: 273 SKPMYTPEPDICHELLGHVPLFSDRSFAQ-FSQEIGLASLGAPDEYIEKLAT 323
Score = 73.3 bits (172), Expect = 1e-12
Identities = 38/75 (50%), Positives = 47/75 (62%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQEIGL A K +YWFTVEFGLCK+ +KAYGA LLSS GEL + L+
Sbjct: 301 QFSQEIGLASLGAPDEYIEK-LATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLS 359
Query: 808 DQPELXXFEPAXTXV 852
++P+L E T +
Sbjct: 360 EKPKLLPLELEKTAI 374
Score = 46.8 bits (106), Expect = 1e-04
Identities = 20/51 (39%), Positives = 27/51 (52%)
Frame = +2
Query: 47 LTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
L+ + PWFPR +LD + + Y ELD +HPGF D YR +K
Sbjct: 109 LSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 79.8 bits (188), Expect = 1e-14
Identities = 41/75 (54%), Positives = 50/75 (66%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQ+IGL A K L YWFTVEFGLCK+ ++KAYGA LLSS GELLH L+
Sbjct: 256 QFSQDIGLASLGASDEEIEKLSTL-YWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLS 314
Query: 808 DQPELXXFEPAXTXV 852
++PE+ F+P V
Sbjct: 315 EEPEIRAFDPEAAAV 329
Score = 69.7 bits (163), Expect = 1e-11
Identities = 25/43 (58%), Positives = 36/43 (83%)
Frame = +2
Query: 71 KTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR +K
Sbjct: 166 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRK 208
Score = 52.8 bits (121), Expect = 2e-06
Identities = 26/43 (60%), Positives = 32/43 (74%)
Frame = +3
Query: 570 DCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
DC HELLGH+P+LAD +FA F+++ GASD EIEKLST
Sbjct: 237 DCCHELLGHVPMLADRTFAQ-FSQDIGLASLGASDEEIEKLST 278
Score = 48.0 bits (109), Expect = 4e-05
Identities = 20/32 (62%), Positives = 24/32 (75%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTW 284
+RRK IAEIAF Y++GDPIP + YT E TW
Sbjct: 205 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 236
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 79.8 bits (188), Expect = 1e-14
Identities = 41/75 (54%), Positives = 50/75 (66%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELLHALN 807
QFSQ+IGL A K L YWFTVEFGLCK+ ++KAYGA LLSS GELLH L+
Sbjct: 252 QFSQDIGLASLGASDEEIEKLSTL-YWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLS 310
Query: 808 DQPELXXFEPAXTXV 852
++PE+ F+P V
Sbjct: 311 EEPEIRAFDPEAAAV 325
Score = 69.7 bits (163), Expect = 1e-11
Identities = 25/43 (58%), Positives = 36/43 (83%)
Frame = +2
Query: 71 KTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR +K
Sbjct: 162 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRK 204
Score = 52.8 bits (121), Expect = 2e-06
Identities = 26/43 (60%), Positives = 32/43 (74%)
Frame = +3
Query: 570 DCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
DC HELLGH+P+LAD +FA F+++ GASD EIEKLST
Sbjct: 233 DCCHELLGHVPMLADRTFAQ-FSQDIGLASLGASDEEIEKLST 274
Score = 48.0 bits (109), Expect = 4e-05
Identities = 20/32 (62%), Positives = 24/32 (75%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTW 284
+RRK IAEIAF Y++GDPIP + YT E TW
Sbjct: 201 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 232
>AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase
protein.
Length = 163
Score = 73.7 bits (173), Expect = 8e-13
Identities = 33/58 (56%), Positives = 44/58 (75%)
Frame = +3
Query: 525 QYVRHNNSPFHTPEPDCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
QYVRH++ PF+TPEPD HELLGH+PLLA+PSFA F++ GAS+ ++KL+T
Sbjct: 1 QYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQ-FSQEIGLASLGASEEAVQKLAT 57
Score = 70.5 bits (165), Expect = 7e-12
Identities = 38/77 (49%), Positives = 47/77 (61%)
Frame = +1
Query: 616 PASPQFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSSIGELL 795
P+ QFSQEIGL A K Y+FTVEFGLCK+ QL+ +GA LLSSI EL
Sbjct: 31 PSFAQFSQEIGLASLGASEEAVQK-LATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELK 89
Query: 796 HALNDQPELXXFEPAXT 846
HAL+ ++ F+P T
Sbjct: 90 HALSGHAKVKPFDPKIT 106
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 63.3 bits (147), Expect = 1e-09
Identities = 27/51 (52%), Positives = 34/51 (66%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREY 341
+RRK A++A YK+GDPIP + +TE E TW VF + L P HACREY
Sbjct: 141 KRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREY 191
Score = 54.4 bits (125), Expect = 5e-07
Identities = 24/53 (45%), Positives = 33/53 (62%)
Frame = +2
Query: 41 FLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
F L E+ + + PWFP+ SDLD+C + + Y ELD +HPGF D YR +K
Sbjct: 93 FTLKEDGMET-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRK 144
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 57.2 bits (132), Expect = 7e-08
Identities = 24/50 (48%), Positives = 29/50 (58%)
Frame = +2
Query: 50 TENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
TE PWFPR S+LD C+H + Y ELD +HPGF D YR +K
Sbjct: 143 TEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRK 192
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 54.8 bits (126), Expect = 4e-07
Identities = 24/53 (45%), Positives = 33/53 (62%)
Frame = +2
Query: 41 FLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRGTQK 199
F L E+ + + PWFP+ SDLD+C + + Y ELD +HPGF D YR +K
Sbjct: 95 FTLNEDGMET-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRK 146
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 52.8 bits (121), Expect = 2e-06
Identities = 26/43 (60%), Positives = 32/43 (74%)
Frame = +3
Query: 570 DCIHELLGHIPLLADPSFAPIFARNWPWHXSGASDSEIEKLST 698
DC HELLGH+P+LAD +FA F+++ GASD EIEKLST
Sbjct: 46 DCCHELLGHVPMLADRTFAQ-FSQDIGLASLGASDEEIEKLST 87
Score = 50.8 bits (116), Expect = 6e-06
Identities = 29/51 (56%), Positives = 33/51 (64%)
Frame = +1
Query: 628 QFSQEIGLGXPRALRILKSKNYLLVYWFTVEFGLCKEXQQLKAYGAALLSS 780
QFSQ+IGL A K L WFTVEFGLCK+ ++KAYGA LLSS
Sbjct: 65 QFSQDIGLASLGASDEEIEKLSTLS-WFTVEFGLCKQNGEVKAYGAGLLSS 114
Score = 48.0 bits (109), Expect = 4e-05
Identities = 20/32 (62%), Positives = 24/32 (75%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTW 284
+RRK IAEIAF Y++GDPIP + YT E TW
Sbjct: 14 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 45
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 43.6 bits (98), Expect = 0.001
Identities = 19/31 (61%), Positives = 23/31 (74%)
Frame = +3
Query: 189 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGT 281
+RRK IAEIAF Y++GDPIP + YT E T
Sbjct: 14 QRRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
>S61396-1|AAD13928.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 41.1 bits (92), Expect = 0.005
Identities = 14/21 (66%), Positives = 17/21 (80%)
Frame = +1
Query: 700 VYWFTVEFGLCKEXQQLKAYG 762
+YWFTVEFG CK+ +KAYG
Sbjct: 5 IYWFTVEFGFCKQGDSIKAYG 25
>BC050663-1|AAH50663.1| 381|Homo sapiens SH3KBP1 protein protein.
Length = 381
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>BC015806-1|AAH15806.1| 665|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AY542305-1|AAT08174.1| 665|Homo sapiens GIG10 protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AY423734-1|AAS00497.1| 665|Homo sapiens migration-inducing gene 18
protein protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL772197-2|CAH71710.1| 665|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL772197-1|CAH71709.1| 553|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 553
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL732423-6|CAI40280.1| 645|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 645
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 25 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 82
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 83 FPSNFIKELSGESDEL 98
>AL732423-4|CAI40277.1| 628|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 628
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 52 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 109
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 110 FPSNFIKELSGESDEL 125
>AL732423-3|CAI40276.1| 665|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL732327-7|CAI40515.1| 208|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 208
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 36 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 93
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 94 FPSNFIKELSGESDEL 109
>AL732327-6|CAI40514.1| 645|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 645
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 25 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 82
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 83 FPSNFIKELSGESDEL 98
>AL732327-3|CAI40511.1| 628|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 628
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 52 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 109
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 110 FPSNFIKELSGESDEL 125
>AL732327-2|CAI40510.1| 665|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL732327-1|CAI40509.1| 553|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 553
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL732325-3|CAI41254.1| 628|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 628
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 52 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 109
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 110 FPSNFIKELSGESDEL 125
>AL732325-2|CAI41253.1| 665|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL732325-1|CAI41252.1| 553|Homo sapiens SH3-domain kinase binding
protein 1 protein.
Length = 553
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AF542051-1|AAN77231.1| 628|Homo sapiens CD2 binding protein CD2BP3
protein.
Length = 628
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 52 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 109
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 110 FPSNFIKELSGESDEL 125
>AF230904-1|AAF37854.1| 665|Homo sapiens c-Cbl-interacting protein
protein.
Length = 665
Score = 34.3 bits (75), Expect = 0.57
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Frame = +3
Query: 165 VSRTKITGERRKQIAEIAFAY----------KYGDPIPSIAYTEIENGTWQRVFNTVLDL 314
+ RT GERR++ ++AF+Y K GD I + E+E G W+ V N +
Sbjct: 89 ILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEGVLNGKTGM 146
Query: 315 MPKHACREYKAAFEKL 362
P + +E ++L
Sbjct: 147 FPSNFIKELSGESDEL 162
>AL591719-1|CAH72065.1| 596|Homo sapiens fibronectin type III
domain containing 7 protein.
Length = 596
Score = 33.1 bits (72), Expect = 1.3
Identities = 26/95 (27%), Positives = 42/95 (44%), Gaps = 1/95 (1%)
Frame = -1
Query: 517 WNTRXXKRGEEVTCRQKTSSRSPG*SQCAYAKKLLTSSSCGIR-*GTNMSAACSFSNAAL 341
WN G++ TC Q+TS R+P Q ++ L +S R G + S+++
Sbjct: 46 WNANRIP-GDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSS- 103
Query: 340 YSLHACLGIKSSTVLNTRCQVPFSISVYAIDGIGS 236
L S T+ + +C + ISV A + GS
Sbjct: 104 -ELTCSTTFSSCTISSLQCGTEYLISVLASNDAGS 137
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 122,943,780
Number of Sequences: 237096
Number of extensions: 2699002
Number of successful extensions: 5592
Number of sequences better than 10.0: 43
Number of HSP's better than 10.0 without gapping: 5233
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5541
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10816958492
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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