Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= MFBP02_F_C17
(893 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 255 2e-67
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 255 2e-67
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 255 2e-67
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 252 1e-66
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 248 2e-65
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 248 2e-65
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 248 2e-65
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 247 4e-65
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 247 4e-65
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 240 6e-63
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 199 1e-50
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 194 3e-49
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 194 3e-49
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 194 3e-49
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 194 3e-49
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 123 8e-28
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 122 1e-27
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 117 5e-26
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 117 5e-26
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 79 2e-14
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 73 1e-12
AL139410-3|CAI12718.1| 902|Homo sapiens RUN and SH3 domain cont... 31 4.3
AL139410-2|CAI12719.1| 796|Homo sapiens RUN and SH3 domain cont... 31 4.3
X90568-1|CAA62188.1|26926|Homo sapiens titin protein. 31 5.6
AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein. 31 5.6
AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein. 31 5.6
M81601-1|AAA61138.1| 301|Homo sapiens transcription elongation ... 31 7.5
S75697-1|AAD14181.1| 26|Homo sapiens PAH protein. 30 9.9
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 255 bits (624), Expect = 2e-67
Identities = 128/240 (53%), Positives = 167/240 (69%), Gaps = 3/240 (1%)
Frame = +3
Query: 183 NYIREGRDSTKSTWLLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 359
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 360 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 533
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 534 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 713
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 714 PTHACKEHNHVFPLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
THAC E+NH+FPLL + CG+ +D+IPQLEDVS FL+ TGF LR AG LSSR FL GL
Sbjct: 199 KTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGL 258
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 255 bits (624), Expect = 2e-67
Identities = 128/240 (53%), Positives = 167/240 (69%), Gaps = 3/240 (1%)
Frame = +3
Query: 183 NYIREGRDSTKSTWLLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 359
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 360 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 533
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 534 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 713
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 714 PTHACKEHNHVFPLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
THAC E+NH+FPLL + CG+ +D+IPQLEDVS FL+ TGF LR AG LSSR FL GL
Sbjct: 199 KTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGL 258
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 255 bits (624), Expect = 2e-67
Identities = 128/240 (53%), Positives = 167/240 (69%), Gaps = 3/240 (1%)
Frame = +3
Query: 183 NYIREGRDSTKSTWLLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 359
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 360 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 533
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 534 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 713
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +EE TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLY 198
Query: 714 PTHACKEHNHVFPLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
THAC E+NH+FPLL + CG+ +D+IPQLEDVS FL+ TGF LR AG LSSR FL GL
Sbjct: 199 KTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGL 258
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 252 bits (617), Expect = 1e-66
Identities = 127/240 (52%), Positives = 166/240 (69%), Gaps = 3/240 (1%)
Frame = +3
Query: 183 NYIREGRDSTKSTWLLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSST-RRPGYEFM 359
+YI + + + L+ S +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 360 VECEHGS-GDFGAALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 533
+ S ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 534 GAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELY 713
GAELD+DHPGF DPVYR RRK FADIAYNY+HG+P+P VEY +E TWG VF+ L LY
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLY 198
Query: 714 PTHACKEHNHVFPLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
THAC E+NH+FPLL + CG+ +D+IPQLEDVS FL+ TGF LR AG LSSR FL GL
Sbjct: 199 KTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGL 258
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 248 bits (608), Expect = 2e-65
Identities = 117/220 (53%), Positives = 153/220 (69%), Gaps = 5/220 (2%)
Frame = +3
Query: 249 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 425
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 426 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 593
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 594 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCG 773
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF++L +LYPTHAC+E+ PLL + CG
Sbjct: 146 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCG 205
Query: 774 YRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
YR+D+IPQLEDVSNFL++ TGF++R AG LS R FL+GL
Sbjct: 206 YREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGL 245
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 248 bits (608), Expect = 2e-65
Identities = 117/220 (53%), Positives = 153/220 (69%), Gaps = 5/220 (2%)
Frame = +3
Query: 249 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 425
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 426 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 593
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 594 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCG 773
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF++L +LYPTHAC+E+ PLL + CG
Sbjct: 146 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCG 205
Query: 774 YRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
YR+D+IPQLEDVSNFL++ TGF++R AG LS R FL+GL
Sbjct: 206 YREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGL 245
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 248 bits (607), Expect = 2e-65
Identities = 127/271 (46%), Positives = 174/271 (64%), Gaps = 5/271 (1%)
Frame = +3
Query: 96 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPAAPDEAGSLARY 275
E+ + + + +P SG DK +G N RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGN--KGSNK-REAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 276 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 446
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 447 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 620
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 621 YKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCGYRDDHIPQL 800
YK+G+P+P VEYT+EE TWGVVFR+L++LYPTHAC+E+ FPLL + CGYR+D++PQL
Sbjct: 201 YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQL 260
Query: 801 EDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
EDVS FL++ +GFT+R AG LS R FLAGL
Sbjct: 261 EDVSMFLKERSGFTVRPVAGYLSPRDFLAGL 291
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 247 bits (605), Expect = 4e-65
Identities = 126/265 (47%), Positives = 171/265 (64%), Gaps = 5/265 (1%)
Frame = +3
Query: 114 TAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPAAPDEAGSLARYLGIFSS 293
T ++ +P SG DK G+ RE + T ++ S +E G L + L +F
Sbjct: 38 TFLKLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQE 92
Query: 294 HGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISRNYKDNR 464
VN+ HIESR S RR E V+CE G +F ++ LK + LN + +
Sbjct: 93 KRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEE 152
Query: 465 SA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEP 638
VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A YK+G+P
Sbjct: 153 ELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQP 212
Query: 639 LPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCGYRDDHIPQLEDVSNF 818
+P VEYT+EE TWGVVFR+L++LYPTHAC+E+ FPLL + CGYR+D++PQLEDVS F
Sbjct: 213 IPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMF 272
Query: 819 LRDSTGFTLRXGAGXLSSRXFLAGL 893
L++ +GFT+R AG LS R FLAGL
Sbjct: 273 LKERSGFTVRPVAGYLSPRDFLAGL 297
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 247 bits (605), Expect = 4e-65
Identities = 126/271 (46%), Positives = 173/271 (63%), Gaps = 5/271 (1%)
Frame = +3
Query: 96 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPAAPDEAGSLARY 275
E+ + + + +P SG DK G+ RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 276 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 446
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 447 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 620
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 621 YKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCGYRDDHIPQL 800
YK+G+P+P VEYT+EE TWGVVFR+L++LYPTHAC+E+ FPLL + CGYR+D++PQL
Sbjct: 201 YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQL 260
Query: 801 EDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
EDVS FL++ +GFT+R AG LS R FLAGL
Sbjct: 261 EDVSMFLKERSGFTVRPVAGYLSPRDFLAGL 291
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 240 bits (587), Expect = 6e-63
Identities = 113/220 (51%), Positives = 152/220 (69%), Gaps = 5/220 (2%)
Frame = +3
Query: 249 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 425
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQLNDIFHLLKSHTN 85
Query: 426 YLNIISR-NY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 593
L++ N+ ++ +VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVTPPDNFTMKEEGMESVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 594 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCG 773
KYFAD A +YK+G+P+P VE+T+EE+ TWG VFR+L +LYPTHAC+E+ PLL + CG
Sbjct: 146 KYFADSAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLSKYCG 205
Query: 774 YRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
Y++D+IPQLED+SNFL++ TGF++R AG LS R FL+GL
Sbjct: 206 YQEDNIPQLEDISNFLKERTGFSIRPVAGYLSPRDFLSGL 245
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 199 bits (485), Expect = 1e-50
Identities = 93/183 (50%), Positives = 123/183 (67%), Gaps = 5/183 (2%)
Frame = +3
Query: 249 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 425
+E G L + L IF VNL HIESR S RR +E V+C+ L LK +
Sbjct: 24 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDILHLLKSHTN 83
Query: 426 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 593
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 84 VLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 143
Query: 594 KYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCG 773
KYFAD+A NYKHG+P+P VE+T+EE+ TWG VF++L +LYPTHAC+E+ PLL + CG
Sbjct: 144 KYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCG 203
Query: 774 YRD 782
YR+
Sbjct: 204 YRE 206
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 194 bits (474), Expect = 3e-49
Identities = 101/228 (44%), Positives = 139/228 (60%), Gaps = 5/228 (2%)
Frame = +3
Query: 225 LLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 392
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 111 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 169
Query: 393 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 569
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 170 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 222
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 749
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 223 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 282
Query: 750 PLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
LL GYR+D+IPQLEDVS FL++ TGF LR AG LS+R FLA L
Sbjct: 283 ALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASL 330
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 194 bits (474), Expect = 3e-49
Identities = 101/228 (44%), Positives = 139/228 (60%), Gaps = 5/228 (2%)
Frame = +3
Query: 225 LLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 392
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 393 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 569
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 749
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 255
Query: 750 PLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
LL GYR+D+IPQLEDVS FL++ TGF LR AG LS+R FLA L
Sbjct: 256 ALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASL 303
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 194 bits (474), Expect = 3e-49
Identities = 101/228 (44%), Positives = 139/228 (60%), Gaps = 5/228 (2%)
Frame = +3
Query: 225 LLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 392
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 115 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 173
Query: 393 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 569
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 174 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 226
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 749
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 227 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 286
Query: 750 PLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
LL GYR+D+IPQLEDVS FL++ TGF LR AG LS+R FLA L
Sbjct: 287 ALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASL 334
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 194 bits (474), Expect = 3e-49
Identities = 101/228 (44%), Positives = 139/228 (60%), Gaps = 5/228 (2%)
Frame = +3
Query: 225 LLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 392
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 393 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 569
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVF 749
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW V+ L LY THAC EH F
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAF 255
Query: 750 PLLIENCGYRDDHIPQLEDVSNFLRDSTGFTLRXGAGXLSSRXFLAGL 893
LL GYR+D+IPQLEDVS FL++ TGF LR AG LS+R FLA L
Sbjct: 256 ALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASL 303
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 123 bits (297), Expect = 8e-28
Identities = 71/187 (37%), Positives = 102/187 (54%), Gaps = 5/187 (2%)
Frame = +3
Query: 96 EKEMDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPAAPDEAGSLARY 275
E+ + + + +P SG DK G+ RE + T ++ S +E G L +
Sbjct: 26 EEHQLLGSSTLNKPNSGKNDDKGNK---GSSKREAATESGKTAVVFS--LKNEVGGLVKA 80
Query: 276 LGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELK--KNVGYLNIISR 446
L +F VN+ HIESR S RR E V+CE G +F ++ LK + LN
Sbjct: 81 LRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN 140
Query: 447 NYKDNRSA--VPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYN 620
+ + VPWFPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A
Sbjct: 141 IWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG 200
Query: 621 YKHGEPL 641
YK+G L
Sbjct: 201 YKYGPRL 207
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 122 bits (295), Expect = 1e-27
Identities = 62/131 (47%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
Frame = +3
Query: 249 DEAGSLARYLGIFSSHGVNLSHIESRSSTRRPG-YEFMVECEHGSGDFGAALEELKKNVG 425
+E G L + L IF VNL HIESR S RR +E V+C+ LK +
Sbjct: 26 NEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTN 85
Query: 426 YLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRR 593
L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF D VYR RR
Sbjct: 86 VLSVNLPDNFTLNEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRR 145
Query: 594 KYFADIAYNYK 626
KYFAD+A NYK
Sbjct: 146 KYFADLAMNYK 156
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 117 bits (282), Expect = 5e-26
Identities = 60/157 (38%), Positives = 92/157 (58%), Gaps = 5/157 (3%)
Frame = +3
Query: 225 LLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 392
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 88 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 146
Query: 393 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 569
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 147 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 199
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 680
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 200 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 236
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 117 bits (282), Expect = 5e-26
Identities = 60/157 (38%), Positives = 92/157 (58%), Gaps = 5/157 (3%)
Frame = +3
Query: 225 LLISPAAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRR----PGYEFMVECEHGSGDFG 392
LL SP A + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 393 AALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 569
A L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATW 680
D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 232
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 79.0 bits (186), Expect = 2e-14
Identities = 47/115 (40%), Positives = 62/115 (53%), Gaps = 6/115 (5%)
Frame = +3
Query: 546 DSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHA 725
D DHPGF+D VYR RRK A+IA+ Y+HG+P+P VEYT EE+ATW L + P A
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHV-PMLA 59
Query: 726 CKEHNHVF-PLLIENCGYRDDHIPQLEDVSNF-----LRDSTGFTLRXGAGXLSS 872
+ + + + G D+ I +L +S F L G GAG LSS
Sbjct: 60 DRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSS 114
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 72.9 bits (171), Expect = 1e-12
Identities = 29/44 (65%), Positives = 36/44 (81%)
Frame = +3
Query: 546 DSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVAT 677
D DHPGF+D VYR RRK A+IA+ Y+HG+P+P VEYT EE+AT
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
>AL139410-3|CAI12718.1| 902|Homo sapiens RUN and SH3 domain
containing 1 protein.
Length = 902
Score = 31.5 bits (68), Expect = 4.3
Identities = 17/50 (34%), Positives = 25/50 (50%)
Frame = +3
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPT 719
+PV F ++A K G LP V K++ + W +VF TEL P+
Sbjct: 306 EPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPS 355
>AL139410-2|CAI12719.1| 796|Homo sapiens RUN and SH3 domain
containing 1 protein.
Length = 796
Score = 31.5 bits (68), Expect = 4.3
Identities = 17/50 (34%), Positives = 25/50 (50%)
Frame = +3
Query: 570 DPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPT 719
+PV F ++A K G LP V K++ + W +VF TEL P+
Sbjct: 306 EPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPS 355
>X90568-1|CAA62188.1|26926|Homo sapiens titin protein.
Length = 26926
Score = 31.1 bits (67), Expect = 5.6
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 162 PKLMEGG----NYIREGRDSTKSTWLLIS 236
P L++GG NY+ E RD+TK TW ++S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
>AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein.
Length = 30000
Score = 31.1 bits (67), Expect = 5.6
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 162 PKLMEGG----NYIREGRDSTKSTWLLIS 236
P L++GG NY+ E RD+TK TW ++S
Sbjct: 28315 PPLIDGGSPIINYVIEKRDATKRTWSVVS 28343
>AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein.
Length = 26926
Score = 31.1 bits (67), Expect = 5.6
Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 4/29 (13%)
Frame = +3
Query: 162 PKLMEGG----NYIREGRDSTKSTWLLIS 236
P L++GG NY+ E RD+TK TW ++S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
>M81601-1|AAA61138.1| 301|Homo sapiens transcription elongation
factor SII protein.
Length = 301
Score = 30.7 bits (66), Expect = 7.5
Identities = 17/61 (27%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Frame = +3
Query: 87 PATEKEMDITAKQIEQPTSGSPPDKPKLMEGGNYI-REGRDSTKSTWLLISPAAPDEAGS 263
P+TEK++D K+ + SP + + GN R+ + + T+L P AP + S
Sbjct: 80 PSTEKDLDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYLSSFPRAPSTSDS 139
Query: 264 L 266
+
Sbjct: 140 V 140
>S75697-1|AAD14181.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 30.3 bits (65), Expect = 9.9
Identities = 15/25 (60%), Positives = 16/25 (64%)
Frame = +3
Query: 816 FLRDSTGFTLRXGAGXLSSRXFLAG 890
F+ TGF LR AG LSSR FL G
Sbjct: 2 FIPACTGFCLRPVAGLLSSRDFLGG 26
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 148,371,289
Number of Sequences: 237096
Number of extensions: 3639653
Number of successful extensions: 9963
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 9165
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9946
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 11492727354
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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