Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0007_M15
(645 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 330 2e-90
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 330 2e-90
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 330 2e-90
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 329 4e-90
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 302 6e-82
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 302 6e-82
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 302 6e-82
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 293 5e-79
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 291 2e-78
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 291 2e-78
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 291 2e-78
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 288 1e-77
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 288 1e-77
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 285 7e-77
AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase ... 173 6e-43
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 167 3e-41
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 167 3e-41
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 118 1e-26
S75697-1|AAD14181.1| 26|Homo sapiens PAH protein. 46 2e-04
S61396-1|AAD13928.1| 26|Homo sapiens PAH protein. 44 4e-04
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 42 0.002
S75699-1|AAD14182.1| 26|Homo sapiens PAH protein. 40 0.006
AY563525-1|AAS66667.1| 18|Homo sapiens phenylalanine hydroxyla... 36 0.16
Z94160-2|CAI22122.1| 820|Homo sapiens protein ( Human DNA seque... 32 1.5
AB067491-1|BAB67797.1| 821|Homo sapiens KIAA1904 protein protein. 32 1.5
AY722625-1|AAU11304.1| 17|Homo sapiens phenylalanine hydroxyla... 32 2.0
EF215531-1|ABN11363.1| 293|Homo sapiens MHC class I antigen pro... 31 3.5
EU046491-1|ABS88696.1| 273|Homo sapiens MHC class I antigen pro... 30 6.1
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 330 bits (812), Expect = 2e-90
Identities = 146/197 (74%), Positives = 169/197 (85%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC E+NH+FPLL + CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRD
Sbjct: 194 LKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRD 253
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FL GLAFRVFH TQYIRH S+P+YTPEPD+CHELLGH PLF+D +FAQFSQEIGLASLGA
Sbjct: 254 FLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGA 313
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
PD+YIEKLAT +WFTVEFG+C+Q +KAYGAGLLSSFGELQYCLS+KP L + E TA
Sbjct: 314 PDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTA 373
Query: 546 VTTYPITEYQPVYFVAK 596
+ Y +TE+QP+Y+VA+
Sbjct: 374 IQNYTVTEFQPLYYVAE 390
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 330 bits (812), Expect = 2e-90
Identities = 146/197 (74%), Positives = 169/197 (85%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC E+NH+FPLL + CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRD
Sbjct: 194 LKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRD 253
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FL GLAFRVFH TQYIRH S+P+YTPEPD+CHELLGH PLF+D +FAQFSQEIGLASLGA
Sbjct: 254 FLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGA 313
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
PD+YIEKLAT +WFTVEFG+C+Q +KAYGAGLLSSFGELQYCLS+KP L + E TA
Sbjct: 314 PDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTA 373
Query: 546 VTTYPITEYQPVYFVAK 596
+ Y +TE+QP+Y+VA+
Sbjct: 374 IQNYTVTEFQPLYYVAE 390
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 330 bits (812), Expect = 2e-90
Identities = 146/197 (74%), Positives = 169/197 (85%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC E+NH+FPLL + CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRD
Sbjct: 194 LKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRD 253
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FL GLAFRVFH TQYIRH S+P+YTPEPD+CHELLGH PLF+D +FAQFSQEIGLASLGA
Sbjct: 254 FLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGA 313
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
PD+YIEKLAT +WFTVEFG+C+Q +KAYGAGLLSSFGELQYCLS+KP L + E TA
Sbjct: 314 PDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTA 373
Query: 546 VTTYPITEYQPVYFVAK 596
+ Y +TE+QP+Y+VA+
Sbjct: 374 IQNYTVTEFQPLYYVAE 390
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 329 bits (809), Expect = 4e-90
Identities = 145/197 (73%), Positives = 169/197 (85%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC E+NH+FPLL + CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRD
Sbjct: 194 LKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRD 253
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FL GLAFRVFH TQYIRH S+P+YTP+PD+CHELLGH PLF+D +FAQFSQEIGLASLGA
Sbjct: 254 FLGGLAFRVFHCTQYIRHGSKPMYTPQPDICHELLGHVPLFSDRSFAQFSQEIGLASLGA 313
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
PD+YIEKLAT +WFTVEFG+C+Q +KAYGAGLLSSFGELQYCLS+KP L + E TA
Sbjct: 314 PDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTA 373
Query: 546 VTTYPITEYQPVYFVAK 596
+ Y +TE+QP+Y+VA+
Sbjct: 374 IQNYTVTEFQPLYYVAE 390
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 302 bits (742), Expect = 6e-82
Identities = 136/198 (68%), Positives = 166/198 (83%)
Frame = +3
Query: 3 KLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSR 182
+L+ LYPTHAC+E+ FPLL + CGYREDN+PQLEDVS FLK+ +GFT+RPVAG LS R
Sbjct: 226 ELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPR 285
Query: 183 DFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLG 362
DFLAGLA+RVFH TQYIRH S PLYTPEPD CHELLGH PL ADP FAQFSQEIGLASLG
Sbjct: 286 DFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLG 345
Query: 363 APDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPEST 542
A D+ ++KLATC++FT+EFG+C+QEG+L+AYGAGLLSS GEL++ LSDK ++ FDP++T
Sbjct: 346 ASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTT 405
Query: 543 AVTTYPITEYQPVYFVAK 596
+ IT +Q YFV++
Sbjct: 406 CLQECLITTFQEAYFVSE 423
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 302 bits (742), Expect = 6e-82
Identities = 136/198 (68%), Positives = 166/198 (83%)
Frame = +3
Query: 3 KLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSR 182
+L+ LYPTHAC+E+ FPLL + CGYREDN+PQLEDVS FLK+ +GFT+RPVAG LS R
Sbjct: 232 ELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPR 291
Query: 183 DFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLG 362
DFLAGLA+RVFH TQYIRH S PLYTPEPD CHELLGH PL ADP FAQFSQEIGLASLG
Sbjct: 292 DFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLG 351
Query: 363 APDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPEST 542
A D+ ++KLATC++FT+EFG+C+QEG+L+AYGAGLLSS GEL++ LSDK ++ FDP++T
Sbjct: 352 ASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTT 411
Query: 543 AVTTYPITEYQPVYFVAK 596
+ IT +Q YFV++
Sbjct: 412 CLQECLITTFQEAYFVSE 429
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 302 bits (742), Expect = 6e-82
Identities = 136/198 (68%), Positives = 166/198 (83%)
Frame = +3
Query: 3 KLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSR 182
+L+ LYPTHAC+E+ FPLL + CGYREDN+PQLEDVS FLK+ +GFT+RPVAG LS R
Sbjct: 226 ELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPR 285
Query: 183 DFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLG 362
DFLAGLA+RVFH TQYIRH S PLYTPEPD CHELLGH PL ADP FAQFSQEIGLASLG
Sbjct: 286 DFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLG 345
Query: 363 APDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPEST 542
A D+ ++KLATC++FT+EFG+C+QEG+L+AYGAGLLSS GEL++ LSDK ++ FDP++T
Sbjct: 346 ASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTT 405
Query: 543 AVTTYPITEYQPVYFVAK 596
+ IT +Q YFV++
Sbjct: 406 CLQECLITTFQEAYFVSE 423
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 293 bits (718), Expect = 5e-79
Identities = 135/197 (68%), Positives = 158/197 (80%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC EH F LL GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RD
Sbjct: 239 LKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARD 298
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FLA LAFRVF TQYIRH S P+++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA
Sbjct: 299 FLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGA 358
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
D+ IEKL+T +WFTVEFG+C+Q G++KAYGAGLLSS+GEL +CLS++P++R FDPE+ A
Sbjct: 359 SDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAA 418
Query: 546 VTTYPITEYQPVYFVAK 596
V Y YQ VYFV++
Sbjct: 419 VQPYQDQTYQSVYFVSE 435
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 291 bits (713), Expect = 2e-78
Identities = 135/197 (68%), Positives = 157/197 (79%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC EH F LL GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RD
Sbjct: 266 LKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARD 325
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FLA LAFRVF TQYIRH S P+++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA
Sbjct: 326 FLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGA 385
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
D+ IEKL+T WFTVEFG+C+Q G++KAYGAGLLSS+GEL +CLS++P++R FDPE+ A
Sbjct: 386 SDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAA 445
Query: 546 VTTYPITEYQPVYFVAK 596
V Y YQ VYFV++
Sbjct: 446 VQPYQDQTYQSVYFVSE 462
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 291 bits (713), Expect = 2e-78
Identities = 135/197 (68%), Positives = 157/197 (79%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC EH F LL GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RD
Sbjct: 239 LKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARD 298
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FLA LAFRVF TQYIRH S P+++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA
Sbjct: 299 FLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGA 358
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
D+ IEKL+T WFTVEFG+C+Q G++KAYGAGLLSS+GEL +CLS++P++R FDPE+ A
Sbjct: 359 SDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAA 418
Query: 546 VTTYPITEYQPVYFVAK 596
V Y YQ VYFV++
Sbjct: 419 VQPYQDQTYQSVYFVSE 435
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 291 bits (713), Expect = 2e-78
Identities = 135/197 (68%), Positives = 157/197 (79%)
Frame = +3
Query: 6 LTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRD 185
L LY THAC EH F LL GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RD
Sbjct: 270 LKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARD 329
Query: 186 FLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 365
FLA LAFRVF TQYIRH S P+++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA
Sbjct: 330 FLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGA 389
Query: 366 PDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTA 545
D+ IEKL+T WFTVEFG+C+Q G++KAYGAGLLSS+GEL +CLS++P++R FDPE+ A
Sbjct: 390 SDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAA 449
Query: 546 VTTYPITEYQPVYFVAK 596
V Y YQ VYFV++
Sbjct: 450 VQPYQDQTYQSVYFVSE 466
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 288 bits (706), Expect = 1e-77
Identities = 129/198 (65%), Positives = 160/198 (80%)
Frame = +3
Query: 3 KLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSR 182
+L LYPTHAC+E+ PLL + CGYREDNIPQLEDVSNFLK+ TGF++RPVAG LS R
Sbjct: 180 ELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPR 239
Query: 183 DFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLG 362
DFL+GLAFRVFH TQY+RH S P YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLG
Sbjct: 240 DFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLG 299
Query: 363 APDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPEST 542
A ++ ++KLATC++FTVEFG+C+Q+G+L+ +GAGLLSS EL++ LS ++ FDP+ T
Sbjct: 300 ASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIT 359
Query: 543 AVTTYPITEYQPVYFVAK 596
IT +Q VYFV++
Sbjct: 360 CKQECLITTFQDVYFVSE 377
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 288 bits (706), Expect = 1e-77
Identities = 129/198 (65%), Positives = 160/198 (80%)
Frame = +3
Query: 3 KLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSR 182
+L LYPTHAC+E+ PLL + CGYREDNIPQLEDVSNFLK+ TGF++RPVAG LS R
Sbjct: 180 ELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPR 239
Query: 183 DFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLG 362
DFL+GLAFRVFH TQY+RH S P YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLG
Sbjct: 240 DFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLG 299
Query: 363 APDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPEST 542
A ++ ++KLATC++FTVEFG+C+Q+G+L+ +GAGLLSS EL++ LS ++ FDP+ T
Sbjct: 300 ASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIT 359
Query: 543 AVTTYPITEYQPVYFVAK 596
IT +Q VYFV++
Sbjct: 360 CKQECLITTFQDVYFVSE 377
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 285 bits (700), Expect = 7e-77
Identities = 127/198 (64%), Positives = 160/198 (80%)
Frame = +3
Query: 3 KLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSR 182
+L LYPTHAC+E+ PLL + CGY+EDNIPQLED+SNFLK+ TGF++RPVAG LS R
Sbjct: 180 ELNKLYPTHACREYLKNLPLLSKYCGYQEDNIPQLEDISNFLKERTGFSIRPVAGYLSPR 239
Query: 183 DFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLG 362
DFL+GLAFRVFH TQY+RH S P YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLG
Sbjct: 240 DFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLG 299
Query: 363 APDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPEST 542
A ++ ++KLATC++FTVEFG+C+Q+G+L+ +GAGLLSS EL++ LS ++ FDP+ T
Sbjct: 300 ASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHVLSGHAKVKPFDPKIT 359
Query: 543 AVTTYPITEYQPVYFVAK 596
IT +Q VYFV++
Sbjct: 360 CKQECLITTFQDVYFVSE 377
>AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase
protein.
Length = 163
Score = 173 bits (420), Expect = 6e-43
Identities = 75/124 (60%), Positives = 98/124 (79%)
Frame = +3
Query: 225 QYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFW 404
QY+RH S P YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLGA ++ ++KLATC++
Sbjct: 1 QYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYF 60
Query: 405 FTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTAVTTYPITEYQPVY 584
FTVEFG+C+Q+G+L+ +GAGLLSS EL++ LS ++ FDP+ T IT +Q VY
Sbjct: 61 FTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVY 120
Query: 585 FVAK 596
FV++
Sbjct: 121 FVSE 124
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 167 bits (406), Expect = 3e-41
Identities = 78/139 (56%), Positives = 99/139 (71%)
Frame = +3
Query: 180 RDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASL 359
R +A +AF+ H R D CHELLGH P+ AD FAQFSQ+IGLASL
Sbjct: 207 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 266
Query: 360 GAPDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPES 539
GA D+ IEKL+T +WFTVEFG+C+Q G++KAYGAGLLSS+GEL +CLS++P++R FDPE+
Sbjct: 267 GASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEA 326
Query: 540 TAVTTYPITEYQPVYFVAK 596
AV Y YQ VYFV++
Sbjct: 327 AAVQPYQDQTYQSVYFVSE 345
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 167 bits (406), Expect = 3e-41
Identities = 78/139 (56%), Positives = 99/139 (71%)
Frame = +3
Query: 180 RDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASL 359
R +A +AF+ H R D CHELLGH P+ AD FAQFSQ+IGLASL
Sbjct: 203 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 262
Query: 360 GAPDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPES 539
GA D+ IEKL+T +WFTVEFG+C+Q G++KAYGAGLLSS+GEL +CLS++P++R FDPE+
Sbjct: 263 GASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEA 322
Query: 540 TAVTTYPITEYQPVYFVAK 596
AV Y YQ VYFV++
Sbjct: 323 AAVQPYQDQTYQSVYFVSE 341
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 118 bits (285), Expect = 1e-26
Identities = 57/100 (57%), Positives = 69/100 (69%)
Frame = +3
Query: 180 RDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASL 359
R +A +AF+ H R D CHELLGH P+ AD FAQFSQ+IGLASL
Sbjct: 16 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 75
Query: 360 GAPDDYIEKLATCFWFTVEFGMCRQEGKLKAYGAGLLSSF 479
GA D+ IEKL+T WFTVEFG+C+Q G++KAYGAGLLSS+
Sbjct: 76 GASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSSY 115
>S75697-1|AAD14181.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 45.6 bits (103), Expect = 2e-04
Identities = 20/25 (80%), Positives = 21/25 (84%)
Frame = +3
Query: 123 FLKDCTGFTLRPVAGLLSSRDFLAG 197
F+ CTGF LRPVAGLLSSRDFL G
Sbjct: 2 FIPACTGFCLRPVAGLLSSRDFLGG 26
>S61396-1|AAD13928.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 44.4 bits (100), Expect = 4e-04
Identities = 17/25 (68%), Positives = 20/25 (80%)
Frame = +3
Query: 384 KLATCFWFTVEFGMCRQEGKLKAYG 458
KLAT +WFTVEFG C+Q +KAYG
Sbjct: 1 KLATIYWFTVEFGFCKQGDSIKAYG 25
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 41.9 bits (94), Expect = 0.002
Identities = 17/29 (58%), Positives = 21/29 (72%)
Frame = +3
Query: 3 KLTHLYPTHACKEHNHVFPLLIENCGYRE 89
+L LYPTHAC+E+ PLL + CGYRE
Sbjct: 178 ELNKLYPTHACREYLKNLPLLSKYCGYRE 206
>S75699-1|AAD14182.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 40.3 bits (90), Expect = 0.006
Identities = 18/25 (72%), Positives = 20/25 (80%)
Frame = +3
Query: 123 FLKDCTGFTLRPVAGLLSSRDFLAG 197
F+ CTGF L+PVA LLSSRDFL G
Sbjct: 2 FIPACTGFRLQPVAVLLSSRDFLGG 26
>AY563525-1|AAS66667.1| 18|Homo sapiens phenylalanine hydroxylase
protein.
Length = 18
Score = 35.5 bits (78), Expect = 0.16
Identities = 13/18 (72%), Positives = 15/18 (83%)
Frame = +3
Query: 216 HSTQYIRHHSRPLYTPEP 269
H TQYIRH S+P+YTP P
Sbjct: 1 HCTQYIRHGSKPMYTPGP 18
>Z94160-2|CAI22122.1| 820|Homo sapiens protein ( Human DNA sequence
from clone RP1-63G5 on chromosome 22q12.3-13.1. ).
Length = 820
Score = 32.3 bits (70), Expect = 1.5
Identities = 27/96 (28%), Positives = 36/96 (37%), Gaps = 3/96 (3%)
Frame = +3
Query: 21 PTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGL 200
P + C EH H FP L Y E+ L +FLK T LS R + +G
Sbjct: 701 PAYHCSEHRHSFPAL-----YYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGY 755
Query: 201 AFRVFH---STQYIRHHSRPLYTPEPDVCHELLGHA 299
+ + ST I RP + + GHA
Sbjct: 756 SSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHA 791
>AB067491-1|BAB67797.1| 821|Homo sapiens KIAA1904 protein protein.
Length = 821
Score = 32.3 bits (70), Expect = 1.5
Identities = 27/96 (28%), Positives = 36/96 (37%), Gaps = 3/96 (3%)
Frame = +3
Query: 21 PTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGL 200
P + C EH H FP L Y E+ L +FLK T LS R + +G
Sbjct: 702 PAYHCSEHRHSFPAL-----YYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGY 756
Query: 201 AFRVFH---STQYIRHHSRPLYTPEPDVCHELLGHA 299
+ + ST I RP + + GHA
Sbjct: 757 SSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHA 792
>AY722625-1|AAU11304.1| 17|Homo sapiens phenylalanine hydroxylase
protein.
Length = 17
Score = 31.9 bits (69), Expect = 2.0
Identities = 13/16 (81%), Positives = 14/16 (87%)
Frame = +3
Query: 81 YREDNIPQLEDVSNFL 128
+ EDNIPQLEDVS FL
Sbjct: 1 FHEDNIPQLEDVSQFL 16
>EF215531-1|ABN11363.1| 293|Homo sapiens MHC class I antigen
protein.
Length = 293
Score = 31.1 bits (67), Expect = 3.5
Identities = 17/49 (34%), Positives = 29/49 (59%)
Frame = +3
Query: 429 RQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTAVTTYPITEYQ 575
R+ +L+AY AGL + +Y + K L+ DP T VT +PI++++
Sbjct: 150 REAEQLRAYLAGLCVEWLR-RYLENGKETLQRADPPKTHVTHHPISDHE 197
>EU046491-1|ABS88696.1| 273|Homo sapiens MHC class I antigen
protein.
Length = 273
Score = 30.3 bits (65), Expect = 6.1
Identities = 17/49 (34%), Positives = 28/49 (57%)
Frame = +3
Query: 429 RQEGKLKAYGAGLLSSFGELQYCLSDKPDLREFDPESTAVTTYPITEYQ 575
R+ +L+AY GL + +Y S K L+ DP T VT +PI++++
Sbjct: 150 REAEQLRAYLEGLCVEWLR-RYLESGKETLQRADPPKTHVTHHPISDHE 197
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 101,741,498
Number of Sequences: 237096
Number of extensions: 2200682
Number of successful extensions: 5915
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 5707
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5915
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 7141427170
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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